KR20100009582A - 아제티딘 유도체 및 프로스타글란딘 ｅ2 길항제로서 그의 용도 - Google Patents
아제티딘 유도체 및 프로스타글란딘 ｅ2 길항제로서 그의 용도 Download PDFInfo
- Publication number
- KR20100009582A KR20100009582A KR1020097025684A KR20097025684A KR20100009582A KR 20100009582 A KR20100009582 A KR 20100009582A KR 1020097025684 A KR1020097025684 A KR 1020097025684A KR 20097025684 A KR20097025684 A KR 20097025684A KR 20100009582 A KR20100009582 A KR 20100009582A
- Authority
- KR
- South Korea
- Prior art keywords
- compounds
- compound
- mmol
- pharmaceutically acceptable
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 **C(N(C1)CC1(COC1=C*C(*)=C*1)C(O)=O)=O Chemical compound **C(N(C1)CC1(COC1=C*C(*)=C*1)C(O)=O)=O 0.000 description 3
- UJKHVSBRPREYPJ-UHFFFAOYSA-N CCCC(C1)(CN1C(OC(C)(C)C)=O)C(OCC(C)C)=O Chemical compound CCCC(C1)(CN1C(OC(C)(C)C)=O)C(OCC(C)C)=O UJKHVSBRPREYPJ-UHFFFAOYSA-N 0.000 description 1
- YWFGYJWDPQNWON-UHFFFAOYSA-N OCC(CC1)(CC1C(c(cc1)ccc1Cl)=O)C(O)=O Chemical compound OCC(CC1)(CC1C(c(cc1)ccc1Cl)=O)C(O)=O YWFGYJWDPQNWON-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91708107P | 2007-05-10 | 2007-05-10 | |
| US60/917,081 | 2007-05-10 | ||
| US1303007P | 2007-12-12 | 2007-12-12 | |
| US61/013,030 | 2007-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100009582A true KR20100009582A (ko) | 2010-01-27 |
Family
ID=39739736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097025684A Ceased KR20100009582A (ko) | 2007-05-10 | 2008-04-28 | 아제티딘 유도체 및 프로스타글란딘 ｅ2 길항제로서 그의 용도 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20080280877A1 (enExample) |
| EP (1) | EP2155666A1 (enExample) |
| JP (1) | JP2010526801A (enExample) |
| KR (1) | KR20100009582A (enExample) |
| CN (1) | CN101679235A (enExample) |
| AP (1) | AP2009005047A0 (enExample) |
| AR (1) | AR066524A1 (enExample) |
| AU (1) | AU2008249744A1 (enExample) |
| BR (1) | BRPI0811444A2 (enExample) |
| CA (1) | CA2686517A1 (enExample) |
| CL (1) | CL2008001305A1 (enExample) |
| CO (1) | CO6260066A2 (enExample) |
| CR (1) | CR11101A (enExample) |
| DO (1) | DOP2009000256A (enExample) |
| EA (1) | EA200901381A1 (enExample) |
| EC (1) | ECSP099727A (enExample) |
| GT (1) | GT200900293A (enExample) |
| IL (1) | IL201874A0 (enExample) |
| MA (1) | MA31366B1 (enExample) |
| MX (1) | MX2009011998A (enExample) |
| PA (1) | PA8779601A1 (enExample) |
| PE (1) | PE20090282A1 (enExample) |
| SV (1) | SV2009003407A (enExample) |
| TN (1) | TN2009000470A1 (enExample) |
| TW (1) | TW200904409A (enExample) |
| UY (1) | UY31070A1 (enExample) |
| WO (1) | WO2008139287A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100256109A1 (en) * | 2007-11-15 | 2010-10-07 | Sarah Elizabeth Skerratt | Azetidines As EP2 Antagonists |
| GEP20125607B (en) * | 2008-11-10 | 2012-08-10 | Pfizer Ltd | Pyrrolidines |
| US20100256385A1 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| TWI589576B (zh) | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| WO2016103097A1 (en) | 2014-12-22 | 2016-06-30 | Pfizer Inc. | Antagonists of prostaglandin ep3 receptor |
| CN110041269A (zh) * | 2019-05-16 | 2019-07-23 | 海门瑞一医药科技有限公司 | 一种2-氯-5-羟基嘧啶的制备方法 |
| AU2020388645B2 (en) * | 2019-11-21 | 2026-03-19 | University Of Utah Research Foundation | TRPV4 receptor ligands |
| WO2022272062A1 (en) | 2021-06-24 | 2022-12-29 | Reservoir Neuroscience, Inc. | Ep2 antagonist compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8300860D0 (en) * | 1983-01-13 | 1983-02-16 | Shell Int Research | Azetidine compounds |
| GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
| GB8509746D0 (en) * | 1985-04-16 | 1985-05-22 | Shell Int Research | Preparing azetidine derivatives |
| TW200300757A (en) | 2001-11-16 | 2003-06-16 | Schering Corp | Azetidinyl diamines useful as ligands of the nociceptin receptor orl-1 |
| DE602006021205D1 (de) * | 2005-10-07 | 2011-05-19 | Exelixis Inc | Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen |
| US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
-
2008
- 2008-04-28 EP EP08737574A patent/EP2155666A1/en not_active Withdrawn
- 2008-04-28 CN CN200880019555A patent/CN101679235A/zh active Pending
- 2008-04-28 WO PCT/IB2008/001070 patent/WO2008139287A1/en not_active Ceased
- 2008-04-28 CA CA002686517A patent/CA2686517A1/en not_active Abandoned
- 2008-04-28 AP AP2009005047A patent/AP2009005047A0/en unknown
- 2008-04-28 JP JP2010507013A patent/JP2010526801A/ja not_active Withdrawn
- 2008-04-28 EA EA200901381A patent/EA200901381A1/ru unknown
- 2008-04-28 MX MX2009011998A patent/MX2009011998A/es not_active Application Discontinuation
- 2008-04-28 AU AU2008249744A patent/AU2008249744A1/en not_active Abandoned
- 2008-04-28 KR KR1020097025684A patent/KR20100009582A/ko not_active Ceased
- 2008-04-28 BR BRPI0811444-7A2A patent/BRPI0811444A2/pt not_active IP Right Cessation
- 2008-05-05 US US12/115,070 patent/US20080280877A1/en not_active Abandoned
- 2008-05-06 CL CL200801305A patent/CL2008001305A1/es unknown
- 2008-05-08 PE PE2008000813A patent/PE20090282A1/es not_active Application Discontinuation
- 2008-05-08 PA PA20088779601A patent/PA8779601A1/es unknown
- 2008-05-08 UY UY31070A patent/UY31070A1/es not_active Application Discontinuation
- 2008-05-09 AR ARP080101988A patent/AR066524A1/es unknown
- 2008-05-09 TW TW097117225A patent/TW200904409A/zh unknown
-
2009
- 2009-11-01 IL IL201874A patent/IL201874A0/en unknown
- 2009-11-05 DO DO2009000256A patent/DOP2009000256A/es unknown
- 2009-11-06 TN TNP2009000470A patent/TN2009000470A1/fr unknown
- 2009-11-06 SV SV2009003407A patent/SV2009003407A/es not_active Application Discontinuation
- 2009-11-09 CO CO09126880A patent/CO6260066A2/es not_active Application Discontinuation
- 2009-11-09 CR CR11101A patent/CR11101A/es not_active Application Discontinuation
- 2009-11-10 GT GT200900293A patent/GT200900293A/es unknown
- 2009-11-10 EC EC2009009727A patent/ECSP099727A/es unknown
- 2009-11-10 MA MA32331A patent/MA31366B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080280877A1 (en) | 2008-11-13 |
| JP2010526801A (ja) | 2010-08-05 |
| TW200904409A (en) | 2009-02-01 |
| MA31366B1 (fr) | 2010-05-03 |
| WO2008139287A1 (en) | 2008-11-20 |
| MX2009011998A (es) | 2009-11-19 |
| CA2686517A1 (en) | 2008-11-20 |
| ECSP099727A (es) | 2009-12-28 |
| DOP2009000256A (es) | 2009-11-30 |
| EP2155666A1 (en) | 2010-02-24 |
| AU2008249744A1 (en) | 2008-11-20 |
| TN2009000470A1 (fr) | 2011-03-31 |
| CO6260066A2 (es) | 2011-03-22 |
| PA8779601A1 (es) | 2009-01-23 |
| EA200901381A1 (ru) | 2010-06-30 |
| SV2009003407A (es) | 2010-01-12 |
| AP2009005047A0 (en) | 2009-12-31 |
| GT200900293A (es) | 2010-05-17 |
| UY31070A1 (es) | 2009-01-05 |
| IL201874A0 (en) | 2010-06-16 |
| CN101679235A (zh) | 2010-03-24 |
| AR066524A1 (es) | 2009-08-26 |
| BRPI0811444A2 (pt) | 2014-10-29 |
| PE20090282A1 (es) | 2009-03-27 |
| CR11101A (es) | 2009-12-04 |
| CL2008001305A1 (es) | 2008-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20100009582A (ko) | 아제티딘 유도체 및 프로스타글란딘 ｅ2 길항제로서 그의 용도 | |
| JP4629036B2 (ja) | アリールアルキルアミン化合物及びその製法 | |
| AU2014204666A1 (en) | Benzylamine derivatives | |
| JP2007534740A (ja) | バソプレッシンＶ１ａ受容体の阻害剤としての３−ヘテロシクリル−４−フェニル−トリアゾール誘導体 | |
| JPWO2006080533A1 (ja) | ３−アミノ−１，２，４−トリアゾール誘導体 | |
| US20070167430A1 (en) | Compounds useful in therapy | |
| CN107428691A (zh) | 取代的n‑双环‑2‑芳基喹啉‑4‑甲酰胺及其用途 | |
| US20110312941A1 (en) | 1,4-disubstituted piperidines as vasopressin receptor via antagonists | |
| US8278343B2 (en) | Pyrrolidines | |
| US20100256109A1 (en) | Azetidines As EP2 Antagonists | |
| JP6231621B2 (ja) | 新規ベンゾアゼピン誘導体及びその医薬用途 | |
| US20080221063A1 (en) | Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa | |
| EP1619185A1 (en) | 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof | |
| US7449462B2 (en) | Triazole derivatives which inhibit vasopressin antagonistic activity | |
| HK1139661A (en) | Azetidine derivatives and their use as prostaglandin e2 antagonists | |
| US20100222365A1 (en) | Substituted triazole deriviatives as oxytocin antagonists | |
| HK1158197A (en) | Pyrrolidines | |
| HK1113927B (en) | Substituted triazole derivatives as oxytocin antagonists | |
| HK1113927A1 (en) | Substituted triazole derivatives as oxytocin antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| PA0105 | International application |
Patent event date: 20091209 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20091209 Comment text: Request for Examination of Application |
|
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20110621 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20111027 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20110621 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |