KR20090106002A - Functional composition derived from natural material for alleviating atopic dermatitis - Google Patents

Abstract

PURPOSE: A functional composition for relieving atopic dermatitis derived from natural materials is provided to ensure the effects of anti-oxidation and irritation relief. CONSTITUTION: A functional composition for relieving atopic dermatitis contains 15-20 weight% of soy bean extract, 45-50 weight% of Centella asiatica extract, 5 weight% of chamomile extract, 20-25 weight% of Glycyrrhiza extract and 10 weight% of alkali ion water which is derived from plant ingredients. The soy bean extract is a black soy bean fermentation extract and is obtained by fermenting soy beans and isolating and purifying the genistein ingredient contained in the soy bean.

Description

Functional composition for atopic dermatitis relief derived from natural products {FUNCTIONAL COMPOSITION DERIVED FROM NATURAL MATERIAL FOR ALLEVIATING ATOPIC DERMATITIS}

The present invention relates to a composition derived from natural products containing soybean extract, centellar extract, chamomile extract, and licorice extract, as a composition for alleviating skin diseases, in particular atopic dermatitis. The composition of the present invention is effective for alleviating skin diseases, particularly atopic dermatitis.

Skin disease refers to abnormal findings on all skin including hair, nails, and toenails of mammals including humans. A typical dermatitis is atopic dermatitis that occurs in people with atopic allergies.

At present, the cause of atopic dermatitis is not clear, but about 70% of patients with atopic dermatitis have a history of atopic dermatitis, and are associated with allergic predispositions, especially allergic rhinitis, asthma, etc. It is understood as one of genetic factors and immune diseases. The disease is characterized by severe severe itching in the early days, so most patients with atopic dermatitis scratch the skin severely, which may be further exacerbated by secondary infection and the patient's mental stability and emotional state.

Moreover, atopic dermatitis is frequent in people with dry skin, weak skin or lack of resistance, and is also caused by skin hypersensitivity to various contaminants and bacteria such as staphylococci. In particular, various contaminants, bacteria, and volatile organic compounds in the air, ozone, and the like, which cause skin hypersensitivity reactions, synergistically exacerbate the symptoms of atopic dermatitis.

Atopic dermatitis suffers from a significant number of people, with 0.5 to 1 percent of the population and 5 to 10 percent of children. The onset of symptoms usually occurs within two to six months of age, especially in infants under one year of age, with 85% occurring before age five. Atopic dermatitis mainly occurs in infancy, but recently, the number of patients after puberty is increasing, and the history is also very long. In the treatment of atopic dermatitis, drugs such as corticosteroids, which can expect high pharmacological effects, are used. However, corticosteroids are problematic for their side effects, and patients are exposed to the risk of side effects during treatment. Moreover, it is well known that rebounding (a dramatic worsening of the lesions that occur after the drug is stopped) may occur when the corticosteroids are discontinued. As a countermeasure for such side effects, nonsteroidal anti-inflammatory agents or antihistamines which do not contain hormones such as corticosteroids are used, but there is a problem that it is difficult to cure.

Therefore, it is urgent to develop amelioration or treatment for atopic dermatitis without side effects, and a preparation that can remove or decompose harmful oxygen generated from various irritating toxic substances or ozone from the skin will be needed.

Accordingly, an object of the present invention is to provide a composition for ameliorating or alleviating skin diseases including atopic dermatitis without side effects present in existing atopic therapeutics.

The present invention, as a result of earnest research to achieve the above object, the composition containing natural plant-derived extracts derived from soybean, centella, chamomile and licorice in a specific component ratio to alleviate skin diseases including atopic dermatitis without any skin irritation The discovery of excellent efficacy has led to the completion of the present invention.

Applicants have found that Genistein contained in soy extract has a strong antioxidant action by increasing the production of SOD (superoxidase dismutase) to remove superoxidase radicals. Therefore, if the anti-oxidative genistein is used in a composition for alleviating atopic dermatitis, the present invention will be completed by restraining or eliminating harmful oxygen that stimulates atopic dermatitis. It is early. Genistein is one of the isoflavones mainly contained in soybeans, and especially the ingredients contained in fermented soybeans. Until now, the efficacy of isoflavones is mostly known in relation to the estrogen hormone, and the present invention will be the first to reveal the efficacy in its skin diseases based on the antioxidant effect of genistein.

In addition, since the centella, chamomile, and licorice contained in the functional composition for atopic dermatitis alleviation of the present invention exhibit itch, irritant effect, bactericidal effect, and anti-inflammatory effect, soybean components and antioxidants that exhibit antioxidant effect The present invention has been completed by discovering that by interacting together, it is possible to remove harmful oxygen that stimulates atopic dermatitis, and to effectively improve the itch, wound, and inflammation frequently seen in atopic dermatitis.

In one embodiment, the functional composition for atopic dermatitis alleviation of the present invention contains 15-20% by weight of soybean extract, 45-50% by weight of Centella extract, 5% by weight of chamomile extract and 20-25% by weight of licorice extract.

As another aspect, the functional composition for atopic dermatitis alleviation of the present invention further contains 10% by weight of anion-generating alkaline ionized water derived from plant components.

Since the composition of the present invention contains only soybeans, particularly soybean fermented extract, centella extract, chamomile extract, and licorice extract, which have been shown to have an antioxidant effect, there is no irritation to the skin, and excellent antioxidant effect and alleviation of irritation. Effect. Therefore, it can exhibit very good efficacy in alleviating a wide range of skin diseases including atopic dermatitis.

The present invention relates to a functional composition for atopic dermatitis alleviation, which has an antioxidant effect and a stimulating effect, containing soybean extract, centella extract, chamomile extract, and licorice extract, including black beans. Furthermore, the functional composition for atopic dermatitis alleviation of the present invention may further contain anion generating alkaline ionized water derived from plant components.

The Applicant has named soybean extracts, in particular soybean fermentation extracts, centella extracts, chamomile extracts and licorice extracts, respectively, as a "natural ion calming agent," which is a blended and purified formulation. It has been found to have an excellent effect on improving skin diseases. In addition, it was found that the effect of improving skin diseases is further enhanced by adding alkaline ionized water derived from plant components that release anions to the "natural ion relaxant".

The composition of the present invention can safely alleviate skin diseases without skin irritation by the effects of the natural plant-derived extracts contained in the composition, sterilizes the skin against various contaminants or bacteria and relieves inflammation, such as skin hypersensitivity reactions Can be suppressed. Specifically, the composition of the present invention is a beneficial effect of natural plant-derived extracts, that is, antioxidant effect on the skin by soybean extract, skin itching and irritation effect by centella extract, bactericidal effect by chamomile extract, and licorice extract The anti-inflammatory effects appear to interact with each other to remove and decompose harmful oxygen that stimulates atopic dermatitis, while at the same time sterilizing and alleviating the itching, wounds and inflammation often seen in atopic dermatitis. Therefore, atopic dermatitis can be effectively alleviated using the functional composition for atopic dermatitis alleviation of the present invention.

In addition, when the composition of the present invention contains anion-generating alkaline ionized water derived from a plant component, the anion-generating alkali ionized water releases an anion to decompose harmful components irritating the skin and to increase the natural immunity of the human body. Therefore, the efficacy of the functional composition for atopic dermatitis alleviation of the present invention can be further enhanced.

The composition of the present invention, in particular, soothes the skin by the antioxidative and irritant effect by genistein in soybean extract. In addition, anion-generating alkaline ionized water derived from plant components contained in the composition of the present invention releases a large amount of anions, anionizes volatile organic compounds that synergize with various contaminants and bacteria that cause atopic dermatitis, and ozone molecules. Disassemble it.

Accordingly, the present invention provides a functional composition that can more effectively alleviate atopic dermatitis by showing a skin irritation-reducing effect and a protective effect against various harmful substances.

In addition, the present invention provides a very safe composition by using only natural plant-derived components as a component of the functional composition for atopic dermatitis alleviation, does not exhibit the side effects as shown in the conventional synthetic-derived atopic dermatitis therapeutics.

Hereinafter, the present invention will be described in more detail.

The composition of the present invention is characterized by containing soybean extract, centella extract, chamomile extract and licorice extract. In addition, the composition of the present invention may further contain anion generating alkaline ionized water derived from a plant component.

More specifically, in one aspect, the composition of the present invention is characterized in that it contains 15-20% by weight of soybean extract, 45-50% by weight of Centella extract, 5% by weight of chamomile extract and 20-25% by weight of licorice extract. .

As another aspect, the composition of the present invention is characterized by further containing 10% by weight of anion-generating alkaline ionized water derived from a plant component.

Hereinafter, the components of the composition of the present invention will be described in more detail.

First, the composition for relieving atopic dermatitis of the present invention contains 15-20% by weight of soy extract. As soybeans that can be used to obtain such a soybean extract, for example, general soybeans such as black soybeans, rats, and white chickpeas can be used, and it is particularly preferable to obtain extracts using black soybeans. When the soybean extract is less than 15% by weight, the antioxidant effect by the soybean extract may be lowered, and when the soybean extract is more than 20% by weight, the content of other components of the functional composition for atopic dermatitis alleviation of the present invention is relatively lowered. do.

With regard to soybean extract components, one major feature of the present invention is the use of soybean fermented extracts. Particularly, in the present invention, a substance called genistein is isolated and purified from isoflavones contained in soybean, which is mainly contained in fermented soybean. Genistein is a substance that is well dissolved in lipids and penetrates the skin in the form of aglycone in which sugar is separated from isoflavones. Genistein has a strong antioxidant activity by increasing the production of SOD (superoxidase dismutase) to remove superoxidase radicals. Therefore, when applied to the skin by showing an excellent antioxidant effect can remove the harmful oxygen, it is possible to alleviate atopic dermatitis sensitive to the stimulation of harmful oxygen.

In general, isoflavone is a vegetable substance extracted from soybean and is well known as a safe substance to human body without side effects. Isoflavones, especially in soybeans, are similar to the female hormone estrogen and are called phytoestrogens, and active research is being conducted as substitutes for estrogens.

Isoflavones contain three nonglycoside (aglycone) didzeins, genistein, glycidane and nine glycosides (glycoside) beta-glycosides (dydazine, genistin, glycidine), 6 "-O-acetyl -Glucoside (Didazine, Genistin, Glycithin), 6 "-O-malonyl-glucoside (Didazine, Genistin, Glycithin). It is also known that the content of glycosides is high in isoflavones of unfermented soybeans, and the content of nonglycosides is high in fermented soybeans. Isoflavones in the form of nonglycosides have high activity, and in particular, genistein exhibits antioxidant activity, good lipid solubility, and excellent skin penetration. The composition of the present invention is configured by extracting and using Zenysteine in soy isoflavin, thus exhibiting an excellent atopic dermatitis alleviation effect by the Genistein showing an antioxidant effect.

These isoflavones have several benefits, based on their similarity to estrogens, preventing and treating menopausal disorders, preventing and treating premenstrual syndromes, preventing and treating osteoporosis and senile fractures, anticancer effects and vascular diseases. It has been shown to show excellent efficacy in the preventive effect and neurological effects associated with menopause. Most of the efficacy currently found is related to disorders related to female estrogen hormones.

However, the composition of the present invention is extracted from the soy isoflavones, in particular, Genistein is used, which is not known previously known as the efficacy of isoflavones, Genistein in isoflavones showing an excellent antioxidant effect on the skin of skin diseases It has now been found for the first time by the applicant that it contributes greatly to alleviation, and the composition of the present invention can be advantageously applied to skin diseases such as atopic dermatitis.

The method of obtaining soybean fermented extract is as follows. First, the soybeans are soaked in water and pulverized, the pulverized material is injected into a ceramic material reactor through which air is permeated and liquid components are not permeated, and then fermented by standing at room temperature of 25-28 ° C for 72 hours. By this fermentation, the soybean meal is solid / liquid separated. The solid / liquid separated soybean fermentation product is filtered by a filter to obtain a soybean fermentation extract.

In addition, the functional composition for atopic dermatitis alleviation of the present invention contains 45-50% by weight of Centella asiatica extract. Centella extract in the composition of the present invention serves to relieve itching and irritation of the skin. Centella as used in the composition of the present invention can be easily obtained from the surroundings as a native plant of Korea. When the Centella extract is less than 45% by weight, itching and irritation effect by the Centella extract may be reduced, and when the Centella extract is more than 50% by weight, the content of the other components of the functional composition for atopic dermatitis relief of the present invention is Relatively low.

Centella has been used as a folk remedy for a long time, and it is known to have an excellent effect on wound healing, and ancient Indians are said to have eaten two centennial leaves every day when the skin appears rough. Centella asiatica extract is also used as a very effective treatment for surgical wounds and 2-3 degree burns. In case of trauma, an ointment containing 0.5-1.0% of asiaticoside in the skin disease wound is prescribed, or 2% of Asianticoside is recommended dose, and it is treated once or twice a day.

Centella asiatica is known as Centella asiatica, which has been shown to promote collagen synthesis. It was found in rat experiments that Centella asiatica extract exhibits a wound healing effect of the dermis by collagen and fibronectin. In terms of skin care, it plays an important role in helping the regeneration of aged skin. In particular, the inclusion of Centella extract in the product is known to play a role in coordinating itching and irritation.

In particular, in the present invention, it is preferable to use the centellar fermentation extract, and the method of obtaining the centellar fermentation extract is as follows. First, the centella leaves and roots are washed and ground. Then, the pulverized material is injected into a ceramic material reactor through which air is permeated and liquid components are not permeated, and then fermented by standing at room temperature of 25-28 ° C. for 72 hours. By virtue of this fermentation, the centellar pulverized product is solid / liquid separated. The solid / liquid separated Centella fermentation is filtered by a filter to obtain Centella fermentation extract.

In addition, the atopic dermatitis relief composition of the present invention contains 5% by weight of chamomile extract. Chamomile extract in the composition of the present invention has a bactericidal action. Chamomile is a type of herb that is easily available around. When the chamomile extract is less than 5% by weight, the bactericidal effect by the chamomile extract may be reduced, when the chamomile extract is more than 5% by weight, the content of other components of the functional composition for atopic dermatitis alleviation of the present invention is relatively lowered. do.

Chamomile is a perennial medicinal plant belonging to the Asteraceae, which is native to India and Europe, and is widely used as a bathing agent in Europe because of its great skin disinfecting effect and systemic beauty effect. In addition, it has been used as a medicinal tea for treating inflammatory diseases, fever and the like. Inorganic components such as terpenes, flavonoids, coumarins, and carlic acids are contained, and about 120 compounds have been reported.

In particular, in the present invention, it is preferable to use chamomile fermented extract, and the method of obtaining chamomile fermented extract is as follows. First, chamomile leaves are washed and ground. Then, the pulverized material is injected into a ceramic material reactor through which air is permeated and liquid components are not permeated, and then fermented by standing at room temperature of 25-28 ° C. for 72 hours. By this fermentation, the chamomile grinds are solid / liquid separated. The solid / liquid separated chamomile fermentation product is filtered by a filter to obtain a chamomile fermentation extract.

In addition, the atopic dermatitis relief composition of the present invention contains 20-25% by weight licorice extract. Licorice extract in the composition of the present invention has an anti-inflammatory action. When the licorice extract is less than 20% by weight, the effect of inhibiting inflammation by the licorice extract may be reduced, when the licorice extract is more than 25% by weight, the content of the other components of the functional composition for atopic dermatitis relief of the present invention is relatively Degrades.

Licorice is rich in vitamins A, B, and vitamin C, which is called a lump of vitamins. Glucose and fructose ingredients keep skin moist and smooth. In addition, licorice has an effect on acne, dermatitis, eczema, sweat band, and also has a whitening effect and soothing effect. Licorice extract is a pure natural product, it is known to have a whitening effect superior to other natural products without side effects on the skin. In addition, it has a detoxification effect and an anti-inflammatory action, and thus will advantageously act on skin diseases involving inflammation including atopic dermatitis.

Licorice is generally used for medicinal roots, but in the present invention, it is preferable to use licorice fermented extract obtained by fermenting licorice leaves. The method of obtaining licorice fermented extract is as follows. First, licorice leaves are washed and ground. Then, the pulverized material is injected into a ceramic material reactor through which air is permeated and liquid components are not permeated, and then fermented by standing at room temperature of 25-28 ° C. for 72 hours. By this fermentation, licorice powder is separated into solid and liquid. The solid liquor separated licorice fermentation is filtered by a filter to obtain a licorice fermentation extract.

In addition, the functional composition for atopic dermatitis alleviation of the present invention may further contain 10% by weight of anion-generating alkaline ionized water derived from plant components. When the anion-generating alkaline ionized water is less than 10% by weight, the effect of releasing anions may be reduced, and when the anion-generating alkali ionized water exceeds 10% by weight, the content of other components of the functional composition for atopic dermatitis relief of the present invention is Relatively low.

As the anion generating alkaline ionized water derived from the plant component used in the composition of the present invention, an anion generating composition derived from the plant component disclosed in Korean Patent Registration Nos. 10-0715378 and 10-0715396 to which the applicant is a patentee is used. More specifically, the anion-generating alkaline ionized water derived from the plant component is mixed with 40 to 50 parts by weight of leek, 30 to 40 parts by weight of pine needles, 10 to 20 parts by weight of green tea leaves, and 10 to 15 parts by weight of onion pulverized powder, This mixture is alkaline ionized water obtained by injecting the mixture into a ceramic material reactor through which air is permeable and liquid components are not permeated, and leaving it to stand at room temperature for 5 to 7 days, followed by filtering the liquid substance produced by the fermentation.

The anion generating alkaline ionized water derived from the above-mentioned plant component releases anion which is harmless to a human body. The anion-generating alkaline ionized water combines with harmful oxygen (active oxygen) generated inside the human body and not only discharges it to the outside of the human body, but also has energy to attract various acidic wastes, thereby increasing the body's natural immunity. Anions are also known to decompose organic compounds and ozone. Therefore, the use of anion-generating alkaline ionized water not only helps to remove various harmful substances that irritate the skin, which is particularly harmful to atopic dermatitis, but also enhances the body's immunity, which will advantageously work to alleviate atopic dermatitis, a kind of immune disease. .

The functional composition for atopic dermatitis alleviation of the present invention exhibits skin irritation, antioxidant, wound healing, anti-inflammatory and skin soothing effects. This effect is thought to be derived from the above-described plant extracts, in particular the antioxidative effect of soybean extract by genistein is thought to contribute greatly to the alleviation of atopic dermatitis by blocking stimulation by harmful oxygen in the skin.

Functional composition for atopic dermatitis relief of the present invention is a yellow liquid material, can be dissolved in water while using an emulsifier to form a stable formulation.

In addition, the compositions of the present invention are pure natural derivatives, generally using 1,3-butylene glycol as a base for formulation, and formulations made with an antiseptic system are stable without any irritation to the skin.

Further, in the stimulation alleviation test conducted by applying a mask sheet prepared by mixing 0.4% Germall 115, 0.4% methyl paraben, and 1.0% of the composition of the present invention, no stimulation appeared after 20 minutes. As a result, it can be seen that the functional composition for atopic dermatitis of the present invention exhibits an excellent irritant effect.

 The formulation of the functional composition for atopic dermatitis alleviation of the present invention is not particularly limited. For example, the functional composition according to the present invention may be used as an external preparation such as creams, gels, lotions, skins, ointments, face washes such as soaps, or quasi-drugs. It is well known in the art to form a composition, such as a composition of the present invention, in one of the formulations described above.

Furthermore, although the composition of the present invention has been described as exhibiting excellent efficacy against atopic dermatitis, it should be understood that it exhibits excellent efficacy against a wide range of skin diseases such as acne and skin eczema.

Hereinafter, the specific manufacture example of this invention is demonstrated.

Production Example  One

45% by weight of Centella fermented extract, chamomile fermented extract 5%, licorice fermented extract 20% by weight, black soybean fermented extract 20% by weight, and 10% by weight of anion-generating alkaline ionized water derived from plant components to prepare a composition of the present invention It was.

Centella is a native plant of Korea. It is a plant commonly found in wet streams, etc., and can also be used to raise it directly. It can also be obtained from a flower garden or the like. In the present invention, the centella was directly grown. Centella leaves were harvested when water was adequate, and roots were washed. Cultivated leaves and roots are pulverized and aged at room temperature for 25-28 ° C. for 72 hours or longer in a ceramic reactor that does not penetrate liquid components and fermented sufficiently. The liquid substance produced by fermentation was filtered and used as centella extract.

Licorice was cultivated and the leaves were collected and used to obtain a licorice extract. Licorice leaves were fermented in the same manner as the centella, and the liquid substance produced by the fermentation was filtered and used as an extract.

Chamomile is a herb that is readily available on the market. Commercially purchased chamomile was fermented in the same manner as the centella, and the liquid substance produced by the fermentation was filtered and used as an extract.

Black soybeans, which were purchased in the market, were soaked in water and ground, fermented in the same manner as the centella, and the liquid material produced by fermentation was filtered and used as an extract.

Anion-generating alkaline ionized water derived from plant components was prepared according to the manufacturing method disclosed in Korean Patent Registration No. 10-0715396, to which the applicant is a patent owner. Specifically, 45 parts by weight of leek, 35 parts by weight of pine needles, 15 parts by weight of green tea leaves, and 10 parts by weight of onion pulverized mixture, the mixture is injected into a ceramic material reactor through which air is permeated and liquid components are not permeated. It is left to stand at room temperature for 7 days to ferment. Next, the liquid substance obtained by fermentation is filtered and anion generating alkaline ionized water is obtained.

The centella extract, licorice extract, chamomile extract, and black soybean extract were mixed with anion generating alkaline ionized water and mixed for 20-30 minutes at a speed of 800-850 rpm in a homogeneous homogenizer. The mixed composition was filtered with a filter to obtain a composition for alleviating atopic dermatitis of the present invention. The pH of the composition was about 5.7-6.5.

Test Example  One

The skin irritation test was performed using the composition obtained in Preparation Example 1.

Skin irritation test was prepared by mixing Germall 115 0.4%, methyl paraben 0.4%, and 1.0% of the composition of the present invention obtained in Preparation Example 1 to the mask sheet, the mask sheet was applied to the skin with dermatitis The stimulus was tested for appearance. 20 minutes after attaching the mask sheet, no irritation appeared, and the skin had a calming effect. As a result, it can be seen that the functional composition of the present invention exhibits an excellent irritant effect.

The functional composition for atopic dermatitis alleviation of the present invention uses only components derived from pure natural substances, so that when applied to inflamed or wounded skin, the condition of the skin without irritation or side effects such as caused by a chemical treatment agent or the like is caused. Improve inflammation, relieve inflammation, and the like. If the composition of the present invention is applied steadily to skin with skin diseases, it is expected that an excellent skin improvement effect can be expected.

Although described above with reference to a preferred embodiment of the present invention, those skilled in the art various modifications and changes to the present invention without departing from the spirit and scope of the invention described in the claims below I can understand that you can.

Claims (10)

A functional composition for atopic dermatitis alleviation containing 15-20% by weight of soybean extract, 45-50% by weight of centella extract, 5% by weight of chamomile extract, and 20-25% by weight licorice extract. The functional composition according to claim 1, further comprising 10% by weight of anion-generating alkaline ionized water derived from a plant component. The functional composition for atopic dermatitis alleviation according to claim 1 or 2, wherein the soybean extract is a black soybean fermented extract. The functional composition for atopic dermatitis alleviation according to claim 1 or 2, wherein the soybean is fermented, and the genistein component contained in the fermented soybean is isolated and purified. The functional composition for atopic dermatitis alleviation according to claim 3, wherein the soybean is fermented, and the genistein component contained in the fermented soybean is separated and purified. The functional composition for atopic dermatitis alleviation according to claim 1 or 2, wherein the Centella extract is a Centella fermentation extract. The functional composition for atopic dermatitis alleviation according to claim 1 or 2, wherein the licorice extract is a licorice fermentation extract. The functional composition for atopic dermatitis alleviation according to claim 1 or 2, wherein the chamomile extract is a chamomile fermented extract. The vegetable material of claim 2, wherein the anion-generating alkaline ionized water derived from the plant component comprises 40 to 50 parts by weight of leek, 30 to 40 parts by weight of pine needles, 15 to 20 parts by weight of green tea leaves, and 10 to 15 parts by weight of onion grind. Functional composition for alleviating atopic dermatitis, characterized in that the liquid substance obtained by mixing and fermenting. A functional skin product for atopic dermatitis relief comprising the functional composition for atopic dermatitis alleviation according to claim 1.