KR20090069484A - Cosmetic composition comprising the herbal mixed extract showing hair-growth stimulating activity and preventing activity from hair loss - Google Patents

Abstract

A composition which contains mixed herbal extracts is provided to ensure excellent stability, prevent hair loss and promote hair growth. A cosmetic composition for preventing hair loss and promoting hair growth comprises 0.01-5 weight% of mixed herbal extracts of Rehmannia glutinosa Libschitz var. purpurea Makino, Polygonum multiflorum THUNB., and Dioscoria tenuipes FR. et SAV. as an active ingredient. The mixed herbal extracts is isolated using water, low alcohol solvent or mixture of methanol, ethanol, and butanol, hexane, butyleneglycol, propyleneglycol, glycerin, acetic acid ethyl, ether, and chloroform. The mixed herbal extract comprises the Rehmannia glutinosa Libschitz var. purpurea Makino, Polygonum multiflorum THUNB., and Dioscoria tenuipes FR. et SAV. in a ratio of 1-10 : 1-5 : 1-5. The composition is used in a form of hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair aerosol and hair soap.

Description

Cosmetic composition having a hair loss prevention and hair growth promoting effect containing a compound herbal extracts {Cosmetic composition comprising the herbal mixed extract showing hair-growth stimulating activity and preventing activity from hair loss}

The present invention relates to a cosmetic composition having a hair loss prevention and hair growth promoting effect containing a composite herbal extract of raw yellow sulfur, sewage and acid powder.

[Document 1] Korean Patent No. 0157667 (1998. 07. 31)

[Document 2] Republic of Korea Patent No. 0161338 (1998. 08. 24)

[Document 3] Korean Patent No. 259037 (2000. 03. 16)

[Document 4] Korean Patent No. 0260673 (2000. 04. 11)

[Document 5] Jung-seop Jung and Hyang-Yak Dictionary, Younglimsa, 1998

Document 6 Seok-Seon Rho et al., Journal of Dermatological Science , 38, pp.89-97, 2005

Human hair has a hair cycle, and after a certain period of time comes to rest from the scalp and fall out irrespective of the hair cycle is called alopecia, is also called toxicosis (禿髮 症) or apox (禿頭 病) disease. In other words, it is a condition in which abnormal hair loss or hair is not present or is poor. Not only the hair but also all the hair stops growing after a certain period of growth and enters the resting phase, and the hair is repeatedly lost to repeat the hair growth. This is called the hair growth cycle. The growth cycle of eyebrows, eyelashes, and fluffy is less than 6 months. On the other hand, hair growth is longer than 2-6 years, resting period is shorter than 2 ~ 3 months, and each has an independent growth cycle. Adults have 2 to 5% of their hair at rest. The hairs at rest are lightly pigmented, glossy, hairy, and easily pulled off with hair and comb. In addition, fever disease, pregnancy, mental stress, such as the growth phase of the hair suddenly enters the resting period, a lot of missing, the cause is eliminated and is recovered. The causes of hair loss known to date include excessive sebum production due to abnormal circulation, abnormal circulation, blood circulation disorders, nutrient deprivation of hair roots, physical factors such as allergies and bacterial infections, genetic factors such as the effects of male hormones, various pollution and processing. It is a combination of environmental factors such as food, shampoo, soap, mousse, hair gel, hair spray, perm, dyeing, hair dryer use, mental and social factors of modern people who are subject to excessive stress, and aging. It is assumed to be. In recent years, most hair loss patients have been found to be responsible for hair loss. Demodex is a parasitic mite belonging to spiders and aphids, which live on the sebaceous glands and hair follicles of human eyelids, around the nose, the ear canal, and the head. Among the conventional hair growth promoting drugs for treating such alopecia, oral finasteride (Finasteride, Merk, USA) and external preparation minoxidil (Minoxidil, Upjohn, USA). Minoxidil has a capillary dilation function that prevents hair loss by applying it to the scalp, but it must be applied twice a day continuously, and only after the drug stays on the scalp for 3 to 4 hours for some effect. In terms of the effect is inadequate, side effects such as itching, irritation appear. Finasteride (Finasteride) has the effect of inhibiting the production of 5α-dihydrotestosterone (DHT), a male hormone that causes hair loss, and is known to have a hair growth or hair loss inhibitory effect when taken for 6 months to 1 year. There was a problem returning to the original state. In addition, side effects may include decreased sexual function, such as decreased libido, erectile dysfunction, etc. Women are known to not take because of the risk of birth defects.

There have also been many attempts to promote hair growth by applying or taking herbal medicines to the scalp, using the extract of orchid plants (Korean Patent No. 0157667), and using the wormwood and mandrel (Korean Patent No. 0161338). ), Half, clove, Bokbunja, Sancho, Manza, Dansam and white porcelain (Korean Patent No. 259037), mungbean flour, soybean flour, black rice flour, perilla sesame powder, sesame powder, walnut powder, laver powder, mussel powder, Oyster powder, anchovy powder, seaweed powder, kelp powder, yeast concentrate or dry powder thereof (Korean Patent No. 0260673) has been published, but its principle of action is not clear and its efficacy has not been sufficiently verified. It is true.

As described above, the above-mentioned hair restorers have problems such as economic burdens and pains to hair loss patients or cause side effects, use of only temporary or fragmentary pharmacological mechanisms, and the effects are more excellent and persistent. There is a growing demand for drugs that do not have side effects.

Rehmannia of the present invention glutinosa Libschitz var . purpurea Makino ) uses fresh roots of perennial herbaceous plants belonging to the family of the current ginseng as a medicinal herb. Fresh root roots are either raw or sulfur, dried or dried, dried or dried, and then steamed and dried in the sun 9 times. Saengjihwang is sweet and bitter taste and nature, cold. Enter the heart, liver and nerves of the twelve meridians. Efficacy has the effect of lowering heat, clearing blood, and helping blood flow to produce fresh blood, making the white hair black (Information et al.

Sewage ( Polygonum multiflorum THUNB.) Is a perennial vine herb belonging to the genus Madipulaceae and is recognized for its weakness comparable to wild ginseng. It is warm, tasteless, bitter, and nontoxic. Sewage looks like sweet potatoes, but slightly smaller, and when ginseng is precious, instead of ginseng, it is used as a substitute for sorghum, or because it is less contraindicated and more digestible than sorghum. Sewage acts as a function of donkey and ripening sulfur to produce and smooth blood, and remove inflammation, boil, and swelling. In addition to sputum and phlegm, it treats postpartum disease, cold and lobular treatment of women There is a function to strengthen the musculature. When used as a life to communicate the energy to facilitate the communication of faeces and detoxification action, and steaming properly or boiled and then dried to write the liver and gods to create blood courses. It is said to blacken the head, make the face beautiful, and to control the postpartum and malaise of the wife, and when it is worn, the white hair becomes black and lustrous (Jung Ji-seop et al., Pp.318, Yeonglimsa, 1998).

Dioscoria tenuipes FR. Et SAV. Is a tuber of Deisocorea batatas, saponin, cholin, starch, glycoprotein, abscisin II and polyphenols. , Vitamin C, etc., to strengthen the body and body, strengthen the five intestines to strengthen energy, strengthen the muscles and bones, control the stomach well, diarrhea and relax the mind, especially effective in preventing aging and rough It is said that it is effective to drink skin steadily to improve skin, energy, tinnitus, and cold sweat, and it helps to dry dry skin (Jung-Sup et al., Hyang-Jeomsa Dictionary, pp.148, Younglim-sa, 1998).

Therefore, the present inventors continue to search for raw materials having excellent stability and hair growth promoting effect among the herbal extracts used as herbal medicines, and confirmed that the herbal extracts of raw yellow sulfur, sewage and acidic medicines have the effect of promoting hair growth through the mouse. The invention was completed.

In order to achieve the above object, the present invention provides a cosmetic composition having a hair loss prevention and hair growth promoting effect containing a raw herbal extract of raw sulfur, sewage and acid as an active ingredient.

Extracts as defined herein are water, including purified water, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, hexane, butylene glycol, propylene glycol, glycerin, ethyl acetate, ethers, chloroform, preferably water Characterized in that the extract is available in.

The combined herbal extract of raw sulfur, sewage and acid extract of the present invention has a composition ratio of raw sulfur: sewage: acid (1-10: 1-5: 1-5), preferably raw sulfur: sewage: acid (1-4: 1) It is characterized by a weight ratio (w / w) of ˜2: 1 to 2).

The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Formulations of hair mousse or hairspray.

Hereinafter, the method for obtaining the extract of the present invention will be described in detail.

The herbal extract of the present invention, after washing the raw sulfur, sewage and acid extract, finely chopped, the composition ratio of raw sulfur: sewage: acid (1-10: 1-5: 1-5), preferably raw sulfur: sewage: Water containing 1 to 5 times, preferably 1 to 2 times the volume of purified water, lower alcohols having 1 to 4 carbon atoms in the weight ratio (w / w) of 1 to 4 to 1 to 2) or these Of a mixed solvent of hexane, butylene glycol, propylene glycol, glycerin, ethyl acetate, ether, chloroform, preferably with water, and added twice a day at 100 ° C. for 1 to 10 hours, preferably 2 to 6 hours. Extraction methods such as cold sediment extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, and the like, preferably, reflux cooling extraction, followed by applying pressure under a 200 mesh sieve to separate the liquid, and the extract can be obtained by concentrating the extract to 40 brix.

The present invention provides a cosmetic composition having a hair loss prevention and hair growth promoting effect, which contains a composite herbal extract of raw yellow sulfur, sewage and acid powder obtained by the above production method as an active ingredient.

The composition of the present invention comprises 0.01 to 10% by weight, preferably 0.1 to 8% by weight and most preferably 0.5 to 5% by weight, based on the total weight of the composition.

It was confirmed that the composite herbal extracts of raw yellow sulfur, sewage and medicinal herbs obtained by the extraction method showed hair growth effects through mice.

The composition comprising the raw herbal extract of the present invention, sewage and acid extract of the compound can be used in a variety of cosmetics and shampoos for hair loss prevention and hair regrowth effect. Examples of products to which the present composition can be added include various softening creams, nourishing creams, nourishing creams, massage creams, essences, packs, hair tonics, hair lotions, shampoos, rinses or soaps.

Cosmetics of the present invention comprises a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The water-soluble vitamins may be any compound that can be incorporated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, and the like. Their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid-2-sodium phosphate salt, ascorbic acid-2-magnesium phosphate salt, etc.) may also be used in the water-soluble vitamins that can be used in the present invention. Included. The water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme or chemical synthesis.

The oil-soluble vitamin may be any compound that can be incorporated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), and the like. And derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenylethyl) Ethers, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.

The polymer peptide may be any compound as long as it can be incorporated into cosmetics. Preferably, collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like can be given. Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.

The polymer polysaccharide may be any compound as long as it can be blended into cosmetics. Preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.) may be mentioned. For example, chondroitin sulfate or its salt can be normally purified from a mammal or fish.

The sphingolipid may be any compound as long as it can be blended into cosmetics. Preferably, ceramide, phytosphingosine, sphingosaccharide lipid, etc. may be mentioned. Sphingo lipids can usually be purified from mammals, fish, shellfish, yeasts or plants by conventional methods or obtained by chemical synthesis.

The seaweed extract may be any compound as long as it can be blended into cosmetics. Preferably, the seaweed extract may include brown algae extract, red algae extract, green algae extract, and the like. Also, calginine, arginic acid, sodium arginate, Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.

In addition to the said essential component, you may mix | blend with the cosmetic composition of this invention the other component normally mix | blended with cosmetics as needed.

Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.

Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.

As ester fats and oils, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl mystinate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl acid isocetyl, isostyl acid isostearyl, isostaryl palmitate, octylate acid octyldodecyl, isostearic acid isetyl, diethyl sebacate, adipine Acid isopropyl, isoalkyl neopentane, tri (capryl, capric acid) glyceryl, trimethyl ethyl trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexanoic penta erythritol Cetyl caprylate, lauric acid decyl, hexyl laurate, decyl myristin, myristin acid myristyl, myritic acid cetyl, stearyl stearate, decyl oleate, rininooleic acid , Isostearyl laurate, isotridecyl myristin, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecate oleate, octylate decyl oleate, octyl dodecyl linoleate, isopropyl isopropyl acid, 2 -Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, propylene glycol dicacapate, capric acid Propylene glycol, dicapric acid neopentyl glycol, dioctanoate neopentyl glycol, tricaprylic acid glyceryl, triundecyl glyceryl, triisopalmitinate glyceryl, triisostearate glyceryl, neopentane dodecyl Isostearyl octanoate, octyl isononate, hexyl decyl neodecanoate, octyl dodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, Sothete octylate, polyglycerol oleate, polyglycerine isostearate, triisocetyl citrate, triisoalkyl citrate, triisoctyl citrate, lauryl lactate, myritic lactate, octyl lactate, octyl lactate, tricitric acid Ethyl, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipicate, diisopropyl sebacinate, Dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, physteryl isostearate, phytic oleate, 12-Steloylhydroxystearate isocetyl, 12-Steloylhydroxystearate stearyl, 12-steal One hydroxy stearic acid and the like esters such as cetearyl source.

Hydrocarbon-based fats and oils, such as squalene, a liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, a liquid isoparaffin, polybutene, microcrystal wax, and a vaseline, etc. are mentioned as a hydrocarbon-type fats and oils.

Examples of the silicone-based oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane and methylsteoxysiloxane copolymer, Alkyl modified silicone oil, amino modified silicone oil, etc. are mentioned.

Perfluoro polyether etc. are mentioned as fluorine-based fats and oils.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed oil, Palm oil, Cucumber nut oil, Wheat germ oil, Rice germ oil, Shea butter, Walnut colostrum oil, Marker demia nut oil, Meadow home oil, Egg yolk oil, Uji, Horse oil, Mink oil, Orange rape oil, Jojoba oil And animal or plant fats and oils such as candeler wax, carnava wax, liquid lanolin and hardened castor oil.

Examples of the moisturizing agent include a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular humectants include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Examples of the fat-soluble low molecular humectants include cholesterol and cholesterol esters.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water soluble chitin, chitosan, and dextrin. Can be.

Examples of the fat-soluble polymers include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.

Examples of the emollient include long-chain acyl glutamic acid cholesteryl esters, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl esters, and the like.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, etc. are mentioned.

As the nonionic surfactant, self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE / POP (polyoxyethylene / polyoxypropylene) copolymer, POE / POP alkyl ether, polyether modified silicone, lauric acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkyl phosphates, and alkylamide phosphates. , Alkyloylalkyl taurine salt, N-acylamino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfo acetate, acyl hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester, etc. are mentioned. .

As cationic surfactant, alkyl trimethylammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium bromide, behenyl trimethyl ammonium chloride, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, lanolin derivatives, quaternary ammonium salts, and the like.

Examples of amphoteric surfactants include the carboxybetaine type, the amide betain type, the sulfobetain type, the hydroxysulfobetain type, the amide sulfobetain type, the phosphobetaine type, the aminocarboxylate type, the imidazoline derivative type, and the amideamine type. An amphoteric surfactant etc. are mentioned.

Organic and inorganic pigments include silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium film mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and composites thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene, styrene copolymer, Organic pigments such as silk powder, cellulose, CI pigment yellow, CI pigment orange, and composite pigments of these inorganic pigments and organic pigments;

As organic powder, Metal soaps, such as a calcium stearate; Alkyl phosphate metal salts such as zinc sodium cetylate, zinc laurate, and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitolyzine, N-alpha-paratoylol nitin, N-alpha-lauroyl arginine, N-alpha-cured fatty acid acyl arginine -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylic acid and benzyl cinnamic acid. , Paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl diisopropyl cinnamic acid ester mixture, wuro Canonic acid, ethyl urokanoate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium sulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy) -1 , 3,5-triazine, 2- (2-hydric Hydroxy-5-methylphenyl) benzotriazole, etc. are mentioned.

As fungicides, hinokithiol, trichloric acid, trichlorohydroxydiphenyl ether, chlorohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, ginphylthione, benzalkonium chloride, Photosensitizer No. 301, mononitrourecosodium sodium, undecylenic acid, etc. are mentioned.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and erythorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol.

In addition, the compounding component which may be added other than this is not limited to this, Moreover, Although all said components can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01-5% weight with respect to gross weight, More Preferably 0.01 to 3% by weight.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture, or the like.

Ingredients included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the extract as an active ingredient, for example, conventional auxiliary agents such as stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.

Functional cosmetic composition for preventing hair loss and promoting hair growth of the present invention may be prepared in any formulation commonly prepared in the art, for example, emulsion, cream, lotion, pack, foundation, lotion, essence, hair cosmetic, etc. Can be mentioned.

When the formulation of the present invention is a paste, cream or gel, animal carriers, vegetable fibers, waxes, paraffins, starches, tracantes, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide, etc. may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the dosage form of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing agent, the aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid as carrier components Amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

As described above, the composition for preventing hair loss and promoting hair growth containing the herbal extract of the present invention shows a hair growth effect through a mouse without any side effects or toxicity to the human body, and thus can be used in cosmetic compositions exhibiting hair loss prevention and hair growth promoting effects. Can be.

Hereinafter, the present invention will be described in detail by the following Examples and Experimental Examples.

However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

Example 1 Preparation of Herbal Extracts

3,600 g of fresh sulfur, 1,800 g of sewage, and 1,800 g of powdered acid purchased from Human Hub were washed, cut into small pieces, put into a mechanical shaker, and 15,000 g of water was added thereto, followed by two months at 100 ° C. for 3 hours. This was then applied under pressure in a 200 mesh sieve to separate the liquor and concentrated to the brine to 40 briquettes to finally yield 2160 g of the combined herbal extracts of saenghwanghwang, sewage and caustic (hereinafter referred to as “A”). It used as the sample of an experiment example.

Experimental Example 1. Experiment of hair growth promoting effect through the mouse

1-1. Experiment preparation

Rho et al. (Seok-Seon Rho et al., Journal of the Invention) to find the actual hair growth promoting effect in mice using A obtained in Example 1 as a sample. of Dermatological Science , 38, pp. 89-97, 2005) was performed as follows.

Six-week-old mice (C57 / BL6, Orient, Korea, 18 to 20 g) were allowed to acclimate in the nursery for one week before the telogen period, and then the mice were anesthetized (ketamine or pentobalbital, Hallym Pharm., Entoval. 70601) is administered intraperitoneally (2.5 mg / individual) to anesthetize. Apply 1 g of a depilatory agent on the back of the anesthetized rat, spread it well, and leave it at room temperature for 2 minutes. Use a scraper to lightly push your back. Haired rats are washed with lukewarm water to remove excess hair. To verify the effect of A, the rats were divided into three groups (day 5: 5 per group; day 10, day 15: 15 per group; day 20: 8 per group) daily with the sample material once daily for 20 days. (2% minoxidil: 0.1 ml, A: 0.3 ml), the negative control was minoxidil solvent (alcohol: 60%, water: 20%, PEG400: 20%), the positive control 2% minoxidil, the experimental group 50 % A was used.

1-2. Observe the hair growth effect

In order to observe the hair growth effect of mice divided into three groups using A obtained in Example 1 as a sample, photographs were taken on the 5th, 10th and 20th days to observe the degree of hair growth progression.

Since the 7-week-old mice are telogen, a period of natural hair loss, their skin appears white after hair removal, and no significant changes were observed until 5 days in both negative and positive controls and experimental groups. Traces of hair follicle growth were observed in the back of mice treated with 50% A. After 5 days, the hair growth of the mice was different according to the experimental group. On the 10th day, almost 70% of hair growth was observed in the back of the group treated with the herbal medicine, and this phenomenon was similar to that of the minoxidil-treated positive control group. After 10 days, hair growth progressed rapidly in almost all mouse groups, and on the 20th, complete hair growth was observed in all groups.

From the results of the experiment it was confirmed that 50% A is effective in hair growth. The effect of 50% A was confirmed that the appearance of hair follicles on the 5th day or the onset of hair growth on the 10th day was similar to or inferior to minoxidil (see FIG. 1).

1-3. Measurement of hair density and thickness

Using the A obtained in Example 1 as a sample, the hair density and thickness of the mice divided into three groups were measured using a color video imaging device (Leadm, Korea) and a polyscope (Leadm, Korea).

As a result of measuring the density of hair, as shown in FIGS. 3, 4 and Table 1, the hair density of the group treated with 50% A showed a similar density level to that of the minoxidil treated group at 10 days, which is more than twice as high as that of the control group. (Turkey test, p <0.001).

As shown in Figs. 5, 6 and Table 2, the hair thickness measurement results showed that the hair density of the group treated with 50% A showed a similar thickness to that of the minoxidil-treated group on the 10th day and was twice as thick as the control group. (Turkey test, p <0.001).

Day 10 (number / cm ² ) Day 15 (number / cm ² ) Control 1,391 ± 64 3,960 ± 53 Minoxidil 4,015 ± 435 ^* 4,664 ± 138 ^* 50% A 3,429 ± 425 ^# 4,882 ± 194 ^{# *} , ^# : Turkey test, p <0.001.

10th day (mm) 15th day (mm) Control 5.67 ± 0.47 13.6 ± 0.47 Minoxidil 12.67 ± 0.47 ^* 17.3 ± 0.47 ^* 50% A 11.33 ± 1.7 ^# 17.0 ± 0 ^{# *} , ^# : Turkey test, p <0.001.

1-3. Skin thickness measurement with mouse

Using the A obtained in Example 1 as a sample, the skin thickness of the mice divided into three groups was tested using a microscope (Moticam 2300; Motic, Hong Kong).

Skin thicknesses of the mouse tissues were fixed by paraffin, and then attached to slides to measure skin thickness. The skin thickness was measured from the stratum corneum to the muscle layer in the dermis, and the average value was obtained by measuring the length at three or more points in at least three skin tissues for each individual, and a statistical test (Turkey test) confirmed whether there was a significant difference. It was.

As shown in FIG. 2 and Table 3, the skin thickness measurement result showed that the skin thickness of the group treated with 50% A was similar to that of the minoxidil treated group at 10 days, which was more than twice higher than the control group. It could be confirmed (p <0.001).

5th day Day 10 Day 15 Day 20 Control 167.6 ± 55.6 175.8 ± 22.5 303.4 ± 45.9 271.0 ± 45.9 Minoxidil 132.9 ± 25.0 282.3 ± 40.7 ^* 321.3 ± 73.6 316.5 ± 62.0 50% A 122.4 ± 14.3 277.1 ± 54.9 ^* 388.1 ± 105.3 299.7 ± 65.8 ^* : Significant increase in Turkey test, p <0.001.

Although the formulation example of the composition containing the crude herbal extract, sewage, and the herbal herbal extract of the present invention will be described, the present invention is not intended to be limited thereto, but is intended to be described in detail.

Formulation example  One. hair Tonic  Produce

A 1% of Example 1

Ethanol 55.0%

Castor Oil 5.0%

Glycerin 3.0%

Pyroctoneamine 0.1%

Spices, pigments

Purified water level

Total 100.0%

Formulation example  2. hair  Lotion

A 1.0% of Example 1

Cetostearyl alcohol 2.0%

Stearyltriethylammonium Chloride 2.0%

Hydroxyethyl cellulose 0.5%

Pyroctonolamine 0.1%

Fragrance, pigment 0.5%

Purified water level

Total 100.0%

Formulation example  3. hair  Manufacture of soap

A 0.1% of Example 1

Titanium Dioxide 0.2%

Polyethylene Glycol 0.8%

Glycerin 0.5%

Ethylenediaminetetraacetic Acid 0.05%

Sodium 1.0%

Color, soap flavor

Cosmetic soap base (13% moisture, parts by weight)

Total 100.0%

1 is a diagram showing the hair growth effect of the mouse coated with the compound herbal extract,

Figure 2 is a diagram showing the results of measuring the skin thickness of the mouse coated with a compound herbal extract,

Figure 3 is a view showing the results of comparing the hair density of the mice coated with the compound herbal extract 10 days,

Figure 4 is a diagram showing the results of comparing the hair density of the mice coated with the compound herbal extract on day 15,

Figure 5 is a view showing the results of comparing the hair thickness of the mice coated with the compound herbal extract 10 days,

Figure 6 is a diagram showing the results of comparing the hair thickness of the mice coated with the compound herbal extract on day 15.

Claims (5)

Cosmetic composition for preventing hair loss and promoting hair growth, containing a crude herbal extract of raw sulfur, sewage and acid powder as an active ingredient. The method of claim 1, wherein the extract is soluble in a solvent selected from lower alcohol solvents such as water, methanol, ethanol, butanol, or a mixed solvent thereof, hexane, butylene glycol, propylene glycol, glycerin, ethyl acetate, ether, chloroform. Cosmetic composition which is an extract. The cosmetic composition according to claim 1, wherein the extract has a weight ratio (w / w) of raw sulfur: sewage: acid powder (1-10: 1-5: 1-5). The cosmetic composition according to claim 1, wherein the extract is contained in an amount of 0.01 to 5% by weight based on the total weight of the composition. The composition of claim 1, wherein the composition comprises hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nourishment cream, hair moisturizer cream, hair massage cream, Hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave agent, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer Cosmetic composition, characterized in that the formulation of the hair moisturizer, hair mousse or hair spray.

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