KR20090043583A - 2-펜옥시 피리미디논 유사체 - Google Patents
2-펜옥시 피리미디논 유사체 Download PDFInfo
- Publication number
- KR20090043583A KR20090043583A KR1020097005810A KR20097005810A KR20090043583A KR 20090043583 A KR20090043583 A KR 20090043583A KR 1020097005810 A KR1020097005810 A KR 1020097005810A KR 20097005810 A KR20097005810 A KR 20097005810A KR 20090043583 A KR20090043583 A KR 20090043583A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- fluorophenyl
- compound
- dihydro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- UFDHZKZCLGSHCD-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-(2,3-difluorophenoxy)-9-methylpurin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=CC=CC(F)=C1F UFDHZKZCLGSHCD-UHFFFAOYSA-N 0.000 claims 1
- GJXOUFXYDLIAPY-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-(2,4-difluorophenoxy)-9-methylpurin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=CC=C(F)C=C1F GJXOUFXYDLIAPY-UHFFFAOYSA-N 0.000 claims 1
- NVZKVRSPSHMFOP-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[2-fluoro-3-(trifluoromethyl)phenoxy]-9-methylpurin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=CC=CC(C(F)(F)F)=C1F NVZKVRSPSHMFOP-UHFFFAOYSA-N 0.000 claims 1
- BICXCCNCLGHDTK-UHFFFAOYSA-N 1-(4-chlorophenyl)-9-methyl-2-(2,3,4-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=CC=C(F)C(F)=C1F BICXCCNCLGHDTK-UHFFFAOYSA-N 0.000 claims 1
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- RDZATZYARLCMSW-UHFFFAOYSA-N 1-(4-chlorophenyl)-9-methyl-2-(2,3,6-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=C(F)C=CC(F)=C1F RDZATZYARLCMSW-UHFFFAOYSA-N 0.000 claims 1
- YEOTUUZZHCYVRA-UHFFFAOYSA-N 1-(4-chlorophenyl)-9-methyl-2-(2,4,5-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(Cl)=CC=3)=O)=C1N=C2OC1=CC(F)=C(F)C=C1F YEOTUUZZHCYVRA-UHFFFAOYSA-N 0.000 claims 1
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- GGWKXPRZXGXJFP-UHFFFAOYSA-N 1-(4-fluorophenyl)-2-[2-fluoro-3-(trifluoromethyl)phenoxy]-9-methylpurin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC=CC(C(F)(F)F)=C1F GGWKXPRZXGXJFP-UHFFFAOYSA-N 0.000 claims 1
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- KQWWMJUVKWGELV-UHFFFAOYSA-N 1-(4-fluorophenyl)-9-methyl-2-(2,3,5-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC(F)=CC(F)=C1F KQWWMJUVKWGELV-UHFFFAOYSA-N 0.000 claims 1
- MSQALPUSJZKFKD-UHFFFAOYSA-N 1-(4-fluorophenyl)-9-methyl-2-(2,3,6-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=C(F)C=CC(F)=C1F MSQALPUSJZKFKD-UHFFFAOYSA-N 0.000 claims 1
- YNOXTIRZIPKHIO-UHFFFAOYSA-N 1-(4-fluorophenyl)-9-methyl-2-(2,4,5-trifluorophenoxy)purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC(F)=C(F)C=C1F YNOXTIRZIPKHIO-UHFFFAOYSA-N 0.000 claims 1
- PWZBGSFKNLUUNT-UHFFFAOYSA-N 1-(4-fluorophenyl)-9-methyl-2-[3-(trifluoromethyl)phenoxy]purin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC=CC(C(F)(F)F)=C1 PWZBGSFKNLUUNT-UHFFFAOYSA-N 0.000 claims 1
- CPSVKYHUCAUTDU-UHFFFAOYSA-N 2,3-difluoro-4-[1-(4-fluorophenyl)-9-methyl-6-oxopurin-2-yl]oxybenzonitrile Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC=C(C#N)C(F)=C1F CPSVKYHUCAUTDU-UHFFFAOYSA-N 0.000 claims 1
- XZCQLTBHLKVBAN-UHFFFAOYSA-N 2-(2,3-difluoro-4-methoxyphenoxy)-1-(4-fluorophenyl)-9-methylpurin-6-one Chemical compound FC1=C(F)C(OC)=CC=C1OC(N(C1=O)C=2C=CC(F)=CC=2)=NC2=C1N=CN2C XZCQLTBHLKVBAN-UHFFFAOYSA-N 0.000 claims 1
- WJMYENCITRBGSP-UHFFFAOYSA-N 2-(2,3-difluoro-4-methoxyphenoxy)-9-ethyl-1-(4-fluorophenyl)purin-6-one Chemical compound CCN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC=C(OC)C(F)=C1F WJMYENCITRBGSP-UHFFFAOYSA-N 0.000 claims 1
- XLSGYAGDGZHLHT-UHFFFAOYSA-N 2-(2,3-difluorophenoxy)-1-(4-fluorophenyl)-9-methylpurin-6-one Chemical compound CN1C=NC(C(N2C=3C=CC(F)=CC=3)=O)=C1N=C2OC1=CC=CC(F)=C1F XLSGYAGDGZHLHT-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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| US82325806P | 2006-08-23 | 2006-08-23 | |
| US60/823,258 | 2006-08-23 |
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| KR20090043583A true KR20090043583A (ko) | 2009-05-06 |
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| GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| EA200900330A1 (ru) | 2006-08-23 | 2009-08-28 | Ньюроджен Корпорейшн | Аналоги 2-феноксипиримидинона |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP3417851B1 (en) | 2013-09-09 | 2020-07-22 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
| EP3180340B1 (en) * | 2014-08-11 | 2018-10-10 | Hydra Biosciences, Inc. | Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives |
| US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
| EP3268362B1 (en) | 2015-03-11 | 2021-10-20 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| WO2016145032A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| US10335388B2 (en) | 2015-04-17 | 2019-07-02 | Peloton Therapeutics, Inc. | Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| WO2020146449A1 (en) * | 2019-01-08 | 2020-07-16 | Texas Tech University System | Small molecule analogs of the protein e4orf1 in the treatment and prevention of metabolic disorders |
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| ES2184960T3 (es) * | 1996-05-15 | 2003-04-16 | Pfizer | Nuevas pirimidin-4-onas-(5,6)-heteroaril condensadas 2,3 disustituidas. |
| CA2288735A1 (en) | 1997-05-08 | 1998-11-12 | Agrevo Uk Limited | Fungicides |
| US6627755B1 (en) * | 1997-06-09 | 2003-09-30 | Pfizer Inc | Quinazolin-4-one AMPA antagonists |
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| WO2002026718A2 (en) | 2000-09-29 | 2002-04-04 | Millennium Pharmaceutical, Inc. | Bicyclic pyrimidin-4-one based inhibitors of factor xa |
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| CZ20032561A3 (cs) | 2001-03-26 | 2003-12-17 | Novartis Ag | Deriváty pyridinu, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
| EP1430161B1 (de) * | 2001-09-28 | 2005-06-15 | DaimlerChrysler AG | Hochfester duplex-/triplex-leichtbaustahl und seine verwendung |
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| WO2004028440A2 (en) | 2002-09-24 | 2004-04-08 | Bayer Healthcare Ag | Vr1 antagonists for the treatment of urological disorders |
| GB0223730D0 (en) | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
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| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
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| AU2006244027A1 (en) * | 2005-05-11 | 2006-11-16 | Merck Sharp & Dohme Limited | 2,3-substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilloid-1 receptor (VR1) |
| GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| CN1318429C (zh) * | 2005-07-25 | 2007-05-30 | 华中师范大学 | 具有杀菌活性的取代噻吩并[3',2':5,6]吡啶并[4,3－d]嘧啶－4(3H)－酮及制备 |
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| CA2668579A1 (en) * | 2006-11-06 | 2008-06-05 | Neurogen Corporation | Cis-cyclohexyl substituted pyrimidinone derivatives |
| WO2008156607A1 (en) | 2007-06-12 | 2008-12-24 | Neurogen Corporation | Substituted pyrimidinones |
| WO2009100403A1 (en) | 2008-02-07 | 2009-08-13 | Neurogen Corporation | Substituted aryl pyrimidinones |
| WO2009121036A2 (en) | 2008-03-27 | 2009-10-01 | Neurogen Corporation | Substituted aryl pyrimidinone derivatives |
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Also Published As
| Publication number | Publication date |
|---|---|
| US8759361B2 (en) | 2014-06-24 |
| EP2061794A4 (en) | 2010-09-08 |
| JP5421108B2 (ja) | 2014-02-19 |
| US8003656B2 (en) | 2011-08-23 |
| AU2007288203B2 (en) | 2013-01-17 |
| WO2008024438A3 (en) | 2008-11-27 |
| GT200900040A (es) | 2010-03-16 |
| IL197043A0 (en) | 2009-11-18 |
| CA2660957C (en) | 2016-10-11 |
| ES2399928T3 (es) | 2013-04-04 |
| WO2008024438A2 (en) | 2008-02-28 |
| BRPI0716582A2 (pt) | 2013-10-08 |
| EP2061794A2 (en) | 2009-05-27 |
| NI200900023A (es) | 2010-03-05 |
| US20120208829A1 (en) | 2012-08-16 |
| EP2061794B1 (en) | 2012-12-05 |
| AU2007288203A1 (en) | 2008-02-28 |
| CO6150167A2 (es) | 2010-04-20 |
| MA30720B1 (fr) | 2009-09-01 |
| JP2010502576A (ja) | 2010-01-28 |
| SV2009003173A (es) | 2010-08-10 |
| CN104292229A (zh) | 2015-01-21 |
| EA200900330A1 (ru) | 2009-08-28 |
| US20090069347A1 (en) | 2009-03-12 |
| CR10675A (es) | 2009-04-17 |
| NO20091182L (no) | 2009-05-14 |
| ZA200901163B (en) | 2010-08-25 |
| TW200825089A (en) | 2008-06-16 |
| CN101506210A (zh) | 2009-08-12 |
| CA2660957A1 (en) | 2008-02-28 |
| MX2009002066A (es) | 2009-03-06 |
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