KR20090027295A - The cosmetic composition for moisturizing of skin containing the thymus quinquecostatus extracts - Google Patents

Abstract

A cosmetic composition is provided to improve antiwrinkle effect and skin-moisturing effect of skin using the Thymus quinquecostatus and to generate side effect including skin trouble. A cosmetic composition 100 weight% contains Thymus quinquecostatus extract of 0.005 ~50 weight% based on . The Thymus quinquecostatus extract is extracted by adding polar solvent selected from water, low-class alcohol of carbon number 1~4 or a mixed solvent thereof in the Thymus quinquecostatus.

Description

The cosmetic composition for moisturizing of skin containing the thymus quinquecostatus extracts}

The present invention is Thymus ( Thymus) quinquecostatus ) relates to a skin moisturizing cosmetic composition containing an extract, the thyme extract not only increases the skin moisturizing power, but also has the effect of inhibiting water evaporation of the epidermis. While there are disadvantages that may cause side effects such as skin troubles, the thyme extract used in the present invention does not cause side effects such as toxicity, skin allergies, and skin troubles by using natural substances, and not only improves skin moisturizing ability but also of skin. It is also effective for wrinkle improvement.

Skin is an indispensable tissue in our lives, a site that is directly affected by physical and chemical injuries from various external factors, as well as having the ability to cure their functional and structural damage. However, our skin is damaged by various contaminants and stress. If the cell proliferation is not properly performed by such damage, the skin is damaged more and more quickly, the elasticity of the skin decreases quickly, and wrinkles Will be generated. As the skin ages, the amount of collagen, mucopolysaccharide, and hyaluronic acid in the matrix, which play an important role in skin elasticity, decreases, and the amount of insoluble collagen increases. This makes it difficult for the dermis to keep the skin hydrated and the skin rough. In addition, the function of the sebaceous glands and sweat glands is also reduced, and the amount of sebum and sweat is gradually reduced. As a result, the sebaceous membrane is not properly formed and the protection against skin hydration is lost. As a result, the skin becomes dry and loses its translucency, thereby reducing the elasticity of skin proteins and producing wrinkles.

On the other hand, if the skin's moisturizing action also fails to function can cause a decrease in skin elasticity. In other words, the loss of the skin's moisturizing power has become an important factor of skin aging. Moisture balance in the skin is controlled by the epidermis. The stratum corneum of the epidermis is the accumulation of dead cells, but plays a very important role in maintaining skin moisture. Human living bodies are mostly composed of water, which plays an important role in maintaining life. Moisture in normal skin is 70% in the body and 20% in the stratum corneum to support the elasticity and flexibility of the skin. If the moisture in the stratum corneum is less than 10%, the skin is known to dry out and cause skin problems. The amount of moisture in the stratum corneum produced by regular keratinization is always 10-20%.

Currently, the main method of maintaining water in the skin is to use an occlusive agent, which is a hydrophobic substance that promotes water retention by forming a barrier on the skin that prevents water loss. The most commonly used occlusion agents include petrolatum, lanolin, cocoa butter, mineral oil and silicone. In addition to the occlusion agent, 20 to 50 different raw materials are generally used to make cosmetics, such as sodium lauryl sulfate, dimethyl sulfoxide, croton oil, and sodium hydroxide. As these raw materials are applied to the product, they may cause irritation, itching and allergy to the skin. When the skin is exposed to irritating substances, the stratum corneum is damaged, and transepidermal water loss, which is an indicator of stratum corneum damage, is increased, which may be a primary inflammatory response.

 Conventional cosmetics have a problem that harmful side effects are generated for the skin due to the above-described reasons, and thus there is a limit in obtaining a skin moisturizing effect, a protective effect, and the like.

Therefore, many studies have been conducted to develop a substance that increases skin moisturization and suppresses skin moisture evaporation without side effects of existing moisturizers.

Accordingly, an object of the present invention is to increase the moisture content of the skin, to suppress the loss of moisture of the epidermis, not to cause side effects such as toxicity, skin allergies, skin problems, etc., as well as to enhance the skin moisturizing power and effective in improving wrinkles of the skin. It is to provide a cosmetic composition.

The present inventors have found that the thyme extract is effective in moisturizing the skin, and when the thyme extract is provided to the cosmetic composition, it was confirmed that the skin moisturizing or skin wrinkle improvement effect is excellent, thereby completing the present invention.

The cosmetic composition containing the thyme extract according to the present invention not only increases the skin moisturizing power of the thyme extract, but also has an effect of inhibiting the evaporation of the epidermis, which significantly inhibits the evaporation of moisture of the epidermis, and is effective in improving the wrinkles of the skin. It can be useful for moisturizing and wrinkle improvement.

The present invention is described in more detail as follows.

Cosmetic composition according to the invention is characterized in that it contains a thyme extract to have a skin moisturizing and skin wrinkle improvement effect.

Thymus quinquecostatus is a plant of the family Lamiaceae and grows in high mountain tops such as Korea, Japan, China, Mongolia, and India or in the crevices of the seashore. Height is 3-15cm, main stem spreads out on the ground, young branches stand at an angle, and smell. The leaves are opposite each other, long oval or lanceolate, 5-12 mm long, and 3-8 mm butterfly. There is a preemption on both sides, the edges are flat or wavy teeth and hairy. Flowers bloom in June in pink, running 2 to 4 on the axilla, 7-9 mm in diameter, gathered at the end of branches, and look like inflorescences. Petioles are hairy, about 3mm long. There are ten ridges on the calyx. Corolla is reddish purple, 7-8mm long, with fine hairs and preoccupation on the outside. There are four surgeries. Fruits are small nuts that ripen in dark brown in September. The stem is thicker, about 15mm long, and about 1cm long, and is called island thyme (var. Japonica). It is planted for ornamental purposes because of its fragrance. It is distributed in Korea, Japan, China, Mongolia, and India.

In the present invention, the thyme extract is extracted from water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, most preferably by adding ethanol.

In addition, the thyme extract according to the present invention can be prepared as follows.

Wash thyme with water and dry in the shade. Dry thyme is placed in the extraction container, an appropriate amount of extraction solvent is added and extracted for a certain time at a suitable temperature. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.

As the extraction solvent, a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof may be used, and preferably ethanol is used.

The amount of the extraction solvent is 2 to 10 times the dry weight of the herbal medicine.

The extraction temperature is 30 ~ 90 ℃, more preferably 60 ~ 80 ℃, most preferably maintained at about 60 ℃ is most effective in the prevention of rot, discoloration and odor.

The extraction time is 5 to 20 hours, preferably 10 hours.

After the thyme extract is obtained, the solids may be removed using a filter paper, the suspension may be centrifuged, and the supernatant may be filtered under reduced pressure.

The filtered extract can be concentrated under reduced pressure at 20 ~ 100 ℃, preferably 50 ~ 70 ℃ with a vacuum rotary concentrator.

In the present invention, the thyme extract may be contained from 0.005 to 50% by weight based on the total weight of the composition. When the content of the thyme extract is less than 0.005% by weight it is difficult to expect the effect, when it exceeds 50.0% by weight does not appear to increase the apparent effect of the increase in content.

The composition of the present invention may further contain one or more active ingredients exhibiting the same or similar functions in addition to the thyme extract.

Cosmetics prepared with a cosmetic composition containing the thyme extract of the present invention as an active ingredient can be prepared in the form of a general emulsion formulation and solubilized formulation. Cosmetics of the emulsified formulations include nutrient cosmetics, creams, essences, etc., and cosmetics of the solubilized formulations are flexible cosmetics. In addition to cosmetics containing the thyme extract of the present invention by containing a dermatologically acceptable medium or base may be prepared in the form of adjuvants that can be topically or systemically applied commonly used in the field of dermatology.

Suitable cosmetic formulations include, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionics (liposomes), nonionics obtained by dispersing an oil phase in a solution, gel, solid or pasty anhydrous product, aqueous phase. It may be provided in the form of a vesicle dispersant, a cream, a skin, a lotion, a powder, an ointment, a spray, or a conceal stick. It may also be prepared in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

In addition, the cosmetic composition of the present invention, in addition to thyme extract, fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water Commonly used in ionic or nonionic emulsifiers, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics It may contain adjuvants conventionally used in the cosmetic or dermatology field, such as any other ingredient. In addition, the above components may be introduced in an amount generally used in the dermatology field.

Examples of products to which the cosmetic composition of the present invention may be added include, for example, cosmetics such as astringent cosmetics, soft cosmetics, nourishing cosmetics, various creams, essences, packs, foundations, and the like, cleansing agents, soaps, treatments, and essences. Etc.

Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, Formulations such as soaps, shampoos, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, emulsions, press powders, loose powders, eye shadows and the like.

Hereinafter, preferred examples and experimental examples are presented to help understand the present invention. However, the following Examples and Experimental Examples are only provided to more easily understand the present invention, and the contents of the present invention are not limited by the Examples.

Production Example  1: Preparation of Thyme Extract

50 g of thyme was finely crushed in a crusher and immersed in 200 ml of 50% ethanol and warmed in an 80 ° C. water bath for 2 hours or more. The obtained extract was cooled to room temperature and filtered through a filter paper to give a filtrate. Ethanol was evaporated from the filtrate using nitrogen, concentrated, and then dissolved in 10% ethanol to prepare an extract.

Test Example  1: Cytoprotective effect test

The cytoprotective effect of the thyme extract prepared in Preparation Example 1 was measured. Fibroblasts are seeded in well plates at 2 * 10 ⁵ . As the medium, a commonly used DMEM medium was used and incubated for 24 hours in 10% FBS. The thyme extract was treated here, and irradiated with ultraviolet rays of 2MED for 10 minutes and incubated for 24 hours. Cell viability was measured using MTT assay, the results are shown in Table 1.

Sample concentration (ug / ml) Cytoprotective effect (%) UV irradiation + extract 0 0 UV irradiation + extract 50 55 UV irradiation + 100 extracts 87 UV irradiation + extract 200 98

Production Example  2 : Example  And Comparative example

A cosmetic composition containing the thyme extract of Preparation Example 1 was prepared, and a cosmetic composition lacking the thyme extract was prepared according to the composition ratio of Table 2 below.

division Content (% by weight) ingredient Example Comparative example Thyme Extract 4.0 - Cetearyl Octanoate 5.0 5.0 Isopropyl Palmitate 5.0 5.0 Polyacrylamide / C13-14 Isoparaffin / Laureth-7 2.0 2.0 Polysorbate 60 1.7 1.7 Solbitan Sesquioleate 1.3 1.3 Spices, preservatives dose dose Purified water Remaining amount Remaining amount Sum 100 100

Test Example  2 : Moisturizing  Improve clinical effect

The clinical effect of improving skin moisturizing power of cosmetics containing thyme extract of the present invention was measured. Twenty females aged 36 to 59 years (mean age 48) were selected and those with dry skin with less than 65 moisture levels were selected. After determining the two parts to be measured and measuring the moisture content of the skin three times each, and formulated according to the above Table 2 and applying for 4 weeks (two times / day), the corneometer (Corneometer Courage) which is a skin moisture content measuring device & Khazaka, Germany) to measure the moisture in the epidermal layer just below the stratum corneum and the results are shown in Table 3.

Comparative example Example Subject D0 D28 D0 D28 One 63 41 65 37 2 63 42 54 42 3 51 63 54 49 4 49 - 52 - 5 62 45 65 69 6 65 45 55 44 7 37 37 51 50 8 55 29 61 45 9 63 68 54 59 10 27 25 39 58 11 33 28 29 34 12 30 28 45 40 13 44 37 61 45 14 46 41 32 30 15 41 29 44 40 16 57 62 45 51 17 64 47 64 51 18 44 44 25 29 19 61 56 46 53 20 40 55 48 67 Average 54 45 54 47 △ 28 13%

From the results shown in Table 3 above, when looking through the relative numerical calculation before / after the application of the example, the result of measuring the moisture level of the corneometer measured 28 days after the application of the example containing the thyme extract was confirmed that the moisture content increased by 13% there was. This effect was observed in 68% of the subjects.

As a result, the fact that it can be confirmed through the results shown in Table 3 shows that the cosmetics containing the thyme extract prepared by Preparation Example 2 according to the present invention enhance skin moisture and exert an excellent effect on skin moisturizing power. Can be.

Test Example  3: Transdermal  Clinical Effect of Inhibiting Water Evaporation

The clinical effect of inhibiting transdermal moisture evaporation on cosmetics containing the thyme extract of the present invention was measured. Twenty females aged 36 to 59 years (mean age 48) were selected and those with dry skin with less than 65 moisture levels were selected. After determining the two sites to be measured and measuring the moisture content of the skin three times each, and formulated according to the above Table 2 and applying for 4 weeks (two times / day), the Tewameter Courage, a transdermal moisture evaporation measuring device & Khazaka, Germany) to measure the amount of water evaporated.

          (Before)-(after) = (△ TEWL)

Subject Example (ΔTEWL) Comparative Example (△ TEWL) One 7 2 2 5 3 3 5 3 4 6 2 5 4 5 6 5 4 7 7 3 8 8 3 9 6 2 10 7 One 11 6 One 12 5 2 13 8 One 14 8 4 15 4 3 16 3 2 17 6 3 18 6 2 19 5 2 20 7 4 Average 5.9 2.6

From the results shown in Table 4, the inhibition of transdermal moisture evaporation in the case of Example was 5.9, more than twice as high as 2.6 of the comparative example.

As a result, it can be confirmed through the results shown in Table 4 that the cosmetic composition containing the thyme extract prepared by Preparation Example 2 according to the present invention is to suppress the skin moisture loss, showing an excellent effect on skin moisturizing power Able to know.

Test Example  4: Clinical effect of external wrinkle improvement

The clinical effect of skin wrinkle improvement on cosmetics containing thyme extract of the present invention was measured. Twenty women aged 42 to 55 years (mean age 50) were included. After formulating according to Preparation Example 2 was applied for 28 days (2 times / day), a replica plate was prepared and analyzed using S.I.A (silicone image analysis), and the results are shown in Tables 5 to 7.

Wrinkles Comparative example Experimental Example Subject D0 D28 D0 D28 One 344 216 292 187 2 212 199 297 329 3 185 190 261 288 4 197 307 216 163 5 155 162 190 242 6 154 153 195 222 7 167 142 152 123 8 150 215 144 151 9 162 165 197 166 10 194 127 185 135 11 174 135 - 150 12 150 224 392 229 13 69 108 85 84 14 73 - 136 - 15 116 162 124 257 16 153 185 218 137 17 205 324 152 117 18 147 195 176 138 19 138 179 203 200 20 233 210 199 277 21 211 154 135 170 22 123 173 131 - 23 296 198 136 161 24 178 282 237 239 Average 226 222 183 192 △ (%) -6

All wrinkles Comparative example Experimental Example Subject D0 D28 D0 D28 One 19.56 11.89 20.98 12.50 2 27.36 20.86 30.87 25.27 3 15.36 20.84 15.45 23.44 4 23.44 18.33 27.22 19.93 5 19.69 26.97 27.69 24.99 6 17.93 14.13 27.09 16.66 7 17.41 20.27 31.57 25.53 8 16.72 28.00 19.24 16.11 9 24.75 24.56 27.63 17.24 10 4.38 13.79 18.75 31.88 11 21.62 11.66 - 17.32 12 14.32 28.94 20.97 14.01 13 14.72 17.66 15.47 8.33 14 20.35 - 19.39 - 15 25.32 27.60 20.41 22.58 16 20.72 19.51 23.98 28.98 17 20.40 17.82 10.86 7.26 18 34.70 15.20 24.57 24.09 19 28.21 27.26 26.41 24.29 20 13.15 28.26 26.29 24.79 21 23.28 31.59 31.73 22.74 22 10.91 8.70 10.40 - 23 23.98 8.13 20.08 18.25 24 10.57 33.80 29.98 22.50 Average 39.83 21.69 23.68 20.22 △ (%) -13

Wrinkle Length Comparative example Experimental Example Subject D0 D28 D0 D28 One 86.72 114.61 112.36 95.59 2 153.38 127.01 189.27 98.12 3 81.14 101.49 102.03 128.78 4 170.43 156.43 117.19 101.95 5 84.54 140.48 162.87 159.85 6 98.70 71.82 145.99 119.16 7 102.42 88.05 140.58 128.12 8 101.91 135.01 48.47 121.60 9 112.58 126.07 136.10 115.39 10 31.87 87.17 77.69 138.12 11 107.09 171.49 34.87 50.39 12 90.74 158.44 158.01 104.69 13 43.57 65.44 120.11 35.17 14 118.77 126.14 92.00 108.57 15 135.07 149.56 134.65 111.29 16 92.19 52.40 113.08 96.05 17 111.33 110.74 89.27 53.93 18 125.77 160.78 165.28 88392 19 145.61 98.91 95.50 125.20 20 174.48 133.66 125.86 168.76 21 99.61 99.56 109.78 122.73 22 58.99 59.05 123.87 90.69 23 105.59 118.29 86.64 81.56 24 102.50 115.00 170.45 120.29 Average 107.15 71.95 62.86 109.93 △ (%) -13

As shown in Tables 5 to 7, after 28 days of application, the total wrinkle area and the wrinkle length were reduced by 13%, the number of wrinkles was also reduced by 6%, and the wrinkle area was reduced in 66% of the total subjects. It was confirmed that there is.

As a result, the fact that it can be confirmed through the results shown in Tables 5, 6 and 7 is a cosmetic containing the herbal extract prepared by the extraction example according to the present invention to enhance the skin wrinkle improvement effect, excellent skin anti-aging It can be seen that it is effective.

Based on the results of the above experimental example, to present a cosmetic composition containing a thyme extract of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation example  1: flexible lotion

Formulation examples of the flexible lotion containing the thyme extract was prepared as shown in Table 8.

Raw material Content (% by weight) Thyme Extract 1.00 1,3-butylene glycol 1.00 Disodium ID 0.05 Allantoin 0.10 Dipotassium glycylizate 0.05 Citrix Acid 0.01 Sodium citrate 0.02 Glyceres-26 1.00 Arbutin 2.00 Hydrogenated Castor Oil 1.00 ethanol 30.00 Preservative a very small amount coloring agent a very small amount Flavor a very small amount Purified water Remaining amount

Formulation example  2: nutrition cream

Formulation example of the nutrition cream containing thyme extract was prepared as shown in Table 9.

Raw material Content (% by weight) Thyme Extract 2.0 1,3-butylene glycol 7.0 glycerin 1.0 D-panthenol 0.1 Plant extracts 3.2 Magnesium Aluminum Silicate 0.3 PEG-40 Stearate 1.2 Stearic acid 2.0 Polysorbate 60 1.5 Lipophilic glyceryl stearate 2.0 Sorbitan sesquioleate 1.5 Cetearyl Alcohol 3.0 Mineral oil 4.0 Squalane 3.8 Carlylic / Capric Triglycerides 2.8 vegetable oil 1.8 Dimethicone 0.4 Dipotassium glycylizate a very small amount Allantoin a very small amount Sodium hyaluronate a very small amount Tocopheryl Acetate Quantity Triethanolamine Quantity Preservative Quantity Flavor Quantity Purified water Remaining amount

Claims (7)

Cosmetic composition for skin moisturizing containing thyme extract The cosmetic composition for moisturizing the skin according to claim 1, wherein the composition promotes skin moisture content. The cosmetic composition for moisturizing the skin according to claim 1, wherein the composition inhibits evaporation of the epidermis and maintains moisture of the stratum corneum.  The cosmetic composition for moisturizing skin according to claim 1, wherein the thyme extract is extracted by adding a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. Cosmetic composition for improving skin wrinkles containing thyme extract. The cosmetic composition according to claim 1 or 5, wherein the content of the thyme extract is 0.005 to 50% by weight based on the total weight of the cosmetic composition. The method of claim 6, wherein the cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, Cosmetic composition, characterized in that any one selected from the group consisting of soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder and eye shadow.