KR20090018838A - 로소니아 인트라셀룰라리스 감염에 대한 어린 동물의 백신접종 - Google Patents
로소니아 인트라셀룰라리스 감염에 대한 어린 동물의 백신접종 Download PDFInfo
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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Landscapes
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| US8834891B2 (en) * | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| US8398994B2 (en) * | 2005-07-15 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia vaccine and methods of use thereof |
| US8470336B2 (en) | 2006-05-25 | 2013-06-25 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of young animals against Lawsonia intracellularis infections |
| US20080241190A1 (en) * | 2006-11-13 | 2008-10-02 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of horses against lawsonia intracellularis |
| US8398970B2 (en) | 2007-09-17 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Method of preventing early Lawsonia intracellularis infections |
| TWI551295B (zh) * | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗 |
| JP5723772B2 (ja) * | 2008-07-22 | 2015-05-27 | インターベット インターナショナル ベー． フェー． | 新規血清型のローソニア・イントラセルラリス細菌、その細菌に基づくワクチン、該新規ローソニア・イントラセルラリス血清型の特定に適した抗体および該抗体を製造するためのハイブリドーマ |
| CN107249625B (zh) * | 2015-02-04 | 2021-09-03 | 英特维特国际股份有限公司 | 用于针对猪中亚临床劳森氏菌感染的疫苗 |
Family Cites Families (49)
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| US3479430A (en) | 1967-08-24 | 1969-11-18 | Diamond Lab Inc | Indirect passive immunization against transmissible gastroenteritis virus in nursing piglets at birth by active immunization of sows prior to farrowing with transmissible gastroenteritis vaccine and method of producing the same |
| US3907987A (en) | 1972-05-25 | 1975-09-23 | Canadian Patents Dev | Enteric disease vaccine |
| US4132597A (en) | 1976-06-09 | 1979-01-02 | Ab Medipharm | Method for cultivation of bacteria |
| US4237218A (en) | 1979-02-09 | 1980-12-02 | Bio-Rad Laboratories, Inc. | Micro-carrier cell culture |
| NL8102786A (nl) * | 1981-06-10 | 1983-01-03 | Duphar Int Res | Werkwijze voor het immuniseren van varkens tegen de ziekte van aujeszky. |
| JPS5991879A (ja) | 1982-11-16 | 1984-05-26 | Hideaki Yamada | シユ−ドモナス属細菌の培養法 |
| DK594084A (da) | 1984-12-12 | 1986-06-13 | Novo Industri As | Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning |
| JPH0644865B2 (ja) | 1985-10-29 | 1994-06-15 | 三菱瓦斯化学株式会社 | カンピロバクタ−属細菌の培養方法 |
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| US5338670A (en) | 1986-07-28 | 1994-08-16 | The United States Of America As Represented By The Department Of Health And Human Services | Production of bordetella pertussis toxin with a low concentration of iron |
| IT1227657B (it) | 1988-12-01 | 1991-04-23 | Mini Ricerca Scient Tecnolog | Antibiotici ab-021 e processo per la loro produzione |
| JPH0822221B2 (ja) | 1988-12-28 | 1996-03-06 | 日東化学工業株式会社 | シュードモナス属細菌の培養法 |
| JPH02308754A (ja) | 1989-05-24 | 1990-12-21 | Yakult Honsha Co Ltd | 乳発酵食品の製造法 |
| US5296221A (en) | 1990-01-31 | 1994-03-22 | Sani-Ei Sucrochemical Co., Ltd. | Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations |
| US5192679A (en) | 1990-05-03 | 1993-03-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Growing ehrlichia species in a continuous cell line |
| DE69132274T2 (de) | 1990-11-01 | 2000-12-14 | Iowa State University Research Foundation, Inc. | Methode der bakteriellen attenuierung und impfstoff |
| DE4208785A1 (de) | 1992-03-19 | 1993-09-23 | Degussa | Verfahren zum auffinden von insertionselementen (is-elemente) oder transposonen |
| AU687750B2 (en) | 1992-09-28 | 1998-03-05 | Wyeth Holdings Corporation | Method of enhancing cell mediated immune responses |
| US5610059A (en) | 1992-11-09 | 1997-03-11 | University Of Arizona | Etiological agent for porcine enteritis |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| US5714375A (en) | 1995-06-05 | 1998-02-03 | Nobl Laboratories, Inc. | Ileal symbiont intracellularis propagation in suspended host cells |
| WO1997020050A1 (en) | 1995-11-30 | 1997-06-05 | Daratech Pty. Ltd. | Therapeutic and diagnostic compositions |
| US7052697B1 (en) | 1999-05-13 | 2006-05-30 | Agriculture Victoria Services Pty Ltd | Lawsonia derived gene and related OmpH polypeptides, peptides and proteins and their uses |
| US20030157120A1 (en) | 1999-05-13 | 2003-08-21 | Michael Panaccio | Lawsonia derived gene and related flge polypeptides, peptides and proteins and their uses |
| US6414036B1 (en) | 1999-09-01 | 2002-07-02 | Van Beek Global/Ninkov Llc | Composition for treatment of infections of humans and animals |
| US6605696B1 (en) | 1999-10-22 | 2003-08-12 | Pfizer, Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| EP1094070A3 (en) * | 1999-10-22 | 2002-01-09 | Pfizer Products Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| US7431931B2 (en) * | 2000-01-28 | 2008-10-07 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and method for preventing reactogenicity associated with administration of immunogenic live rotavirus compositions |
| PL360096A1 (en) | 2000-05-24 | 2004-09-06 | Merial | Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine |
| MY128159A (en) | 2000-06-30 | 2007-01-31 | Wyeth Corp | Methods and composition for oral vaccination |
| AU2001293151B8 (en) | 2000-09-29 | 2006-01-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Improved Vaccines for Proliferative Ileitis and Methods of Making and Using the Same |
| US20020103261A1 (en) | 2000-10-06 | 2002-08-01 | Dusan Ninkov | Compositions for injection or intravenous administration for the treatment of internal infection or inflammation in humans and animals |
| ATE501258T1 (de) | 2000-12-20 | 2011-03-15 | Intervet Int Bv | Lawsonia intracellularis impfstoff |
| US20030087421A1 (en) | 2001-07-11 | 2003-05-08 | Gebhart Connie J | Lawsonia intracellularis |
| WO2004033631A2 (en) | 2002-10-04 | 2004-04-22 | Regents Of The University Of Minnesota | Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using |
| AU2004260657B2 (en) | 2003-07-25 | 2012-06-07 | Boehringer Ingelheim Animal Health USA Inc. | Lawsonia intracellularis of European origin and vaccines, diagnostic agents and methods of use thereof |
| AU2004272246A1 (en) | 2003-09-12 | 2005-03-24 | Intervet International B.V. | Lawsonia intracellularis subunit vaccine |
| DK1709067T3 (da) | 2004-01-22 | 2010-10-11 | Intervet Int Bv | Vacciner med underenhed af Lawsonia intracellularis |
| US7550270B2 (en) | 2004-08-13 | 2009-06-23 | Boehringer Ingelheim Vetmedica, Inc. | Ileitis diagnostic assay |
| US20070212373A1 (en) | 2004-12-08 | 2007-09-13 | Akzo Nobel N.V. | Lawsonia Intracellularis 26 Kd Subunit Vaccine |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| US20090215698A1 (en) | 2005-04-18 | 2009-08-27 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof |
| WO2006116763A2 (en) | 2005-04-28 | 2006-11-02 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia intracellularis immunological proteins |
| US8398994B2 (en) * | 2005-07-15 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia vaccine and methods of use thereof |
| CN102698263B (zh) | 2005-12-29 | 2016-07-06 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 多价pcv2免疫原性组合物和制备此类组合物的方法 |
| US8470336B2 (en) | 2006-05-25 | 2013-06-25 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of young animals against Lawsonia intracellularis infections |
| US20080241190A1 (en) | 2006-11-13 | 2008-10-02 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of horses against lawsonia intracellularis |
| US8398970B2 (en) | 2007-09-17 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Method of preventing early Lawsonia intracellularis infections |
| US8142760B2 (en) | 2008-09-05 | 2012-03-27 | Nathan Len Winkelman | Vaccination for Lawsonia intracellularis |
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| EP2029166A2 (en) | 2009-03-04 |
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| MX2008014882A (es) | 2008-12-05 |
| US8470336B2 (en) | 2013-06-25 |
| JP5257901B2 (ja) | 2013-08-07 |
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