KR20090013804A - 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 - Google Patents

할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 Download PDF

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Publication number
KR20090013804A
KR20090013804A KR1020087028768A KR20087028768A KR20090013804A KR 20090013804 A KR20090013804 A KR 20090013804A KR 1020087028768 A KR1020087028768 A KR 1020087028768A KR 20087028768 A KR20087028768 A KR 20087028768A KR 20090013804 A KR20090013804 A KR 20090013804A
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South Korea
Prior art keywords
substituted
unsubstituted
mmol
kinase
alkyl
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Korean (ko)
Inventor
로날드 제이. 앨버스
레티시아 아얄라
스티븐 에스. 클라린
마리아 메르세데스 델가도 메데로스
로버트 힐그라프
사예 지. 헷지
케빈 휴스
아담 코이스
베로니크 플란테빈-크레니트스키
맥 맥카리크
리사 나돌니
무어티 에스.에스. 팔란키
키란 사하스라무데
존 사피엔자
요시따까 사또
마리안 케이. 슬로스
엘리스 수드벡
조나단 라이트
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시그날 파마소티칼 엘엘씨
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Publication of KR20090013804A publication Critical patent/KR20090013804A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087028768A 2006-04-26 2007-04-25 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 Ceased KR20090013804A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/411,413 2006-04-26
US11/411,413 US7521446B2 (en) 2005-01-13 2006-04-26 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Publications (1)

Publication Number Publication Date
KR20090013804A true KR20090013804A (ko) 2009-02-05

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KR1020087028768A Ceased KR20090013804A (ko) 2006-04-26 2007-04-25 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법

Country Status (14)

Country Link
US (2) US7521446B2 (https=)
EP (1) EP2010186B1 (https=)
JP (1) JP2009535346A (https=)
KR (1) KR20090013804A (https=)
CN (2) CN101478972A (https=)
AU (1) AU2007243287B2 (https=)
BR (1) BRPI0710805A2 (https=)
CA (1) CA2684999C (https=)
ES (1) ES2400257T3 (https=)
IL (1) IL194865A (https=)
MX (1) MX2008013616A (https=)
NZ (1) NZ572467A (https=)
WO (1) WO2007127382A1 (https=)
ZA (3) ZA200809356B (https=)

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RS62496B1 (sr) 2016-04-01 2021-11-30 Signal Pharm Llc (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-piran-4-il)amino)-8-((2,4,6-trihlorofenil)amino)-9h-purin-9-il)-1-metilcikloheksan-1-karboksamid i postupci za njegovu upotrebu
CN109563095B (zh) 2016-06-02 2021-10-29 细胞基因公司 动物和人抗疟剂
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CN111417634A (zh) 2017-10-04 2020-07-14 细胞基因公司 用于制备顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的方法
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Also Published As

Publication number Publication date
CN103351389B (zh) 2015-10-28
WO2007127382A1 (en) 2007-11-08
NZ572467A (en) 2010-10-29
AU2007243287B2 (en) 2012-02-16
IL194865A0 (en) 2009-08-03
AU2007243287A1 (en) 2007-11-08
US20090275564A1 (en) 2009-11-05
US8101588B2 (en) 2012-01-24
CN103351389A (zh) 2013-10-16
CA2684999C (en) 2013-11-26
ZA201103036B (en) 2012-08-29
ZA200907418B (en) 2011-12-28
JP2009535346A (ja) 2009-10-01
ZA200809356B (en) 2010-02-24
MX2008013616A (es) 2009-03-06
US7521446B2 (en) 2009-04-21
IL194865A (en) 2015-08-31
CA2684999A1 (en) 2007-11-08
BRPI0710805A2 (pt) 2011-08-16
US20070060598A1 (en) 2007-03-15
ES2400257T3 (es) 2013-04-08
EP2010186B1 (en) 2012-12-26
CN101478972A (zh) 2009-07-08
EP2010186A1 (en) 2009-01-07

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