KR20080091832A - 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 - Google Patents

중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Download PDF

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KR20080091832A
KR20080091832A KR1020087021183A KR20087021183A KR20080091832A KR 20080091832 A KR20080091832 A KR 20080091832A KR 1020087021183 A KR1020087021183 A KR 1020087021183A KR 20087021183 A KR20087021183 A KR 20087021183A KR 20080091832 A KR20080091832 A KR 20080091832A
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self
cells
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cell
organizing mesenchymal
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모쉐 크후르겔
아담 제이. 카츠
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유니버시티 오브 버지니아 페이턴트 파운데이션
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    • C12N5/0602—Vertebrate cells
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    • C12N2501/38—Hormones with nuclear receptors
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    • C12N2501/392—Sexual steroids

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KR1020087021183A 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Withdrawn KR20080091832A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76333306P 2006-01-30 2006-01-30
US60/763,333 2006-01-30

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KR20080091832A true KR20080091832A (ko) 2008-10-14

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KR1020087021183A Withdrawn KR20080091832A (ko) 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도

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Country Link
US (1) US8592209B2 (https=)
EP (1) EP1984488B1 (https=)
JP (1) JP2009525044A (https=)
KR (1) KR20080091832A (https=)
AU (1) AU2007209870A1 (https=)
CA (1) CA2641022A1 (https=)
WO (1) WO2007089798A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
US8592209B2 (en) 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
JP2010505849A (ja) * 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
US20120100607A1 (en) * 2007-07-12 2012-04-26 Christopher Duntsch Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease
US10633632B2 (en) * 2007-07-12 2020-04-28 Discgenics, Inc. Human disc tissue
JP5509073B2 (ja) 2007-07-12 2014-06-04 ディスクジェニクス ヒト円板組織
KR20100110905A (ko) 2007-07-20 2010-10-13 동국대학교 산학협력단 중간엽 줄기세포를 이용하여 모유두 조직을 제조하는 방법
AU2009205886B2 (en) * 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
US20110059182A1 (en) * 2008-02-05 2011-03-10 University Of Virginia Patent Foundation Spraying device and related method for cell aggregates and cell aggregate suspension thereof
WO2009134532A2 (en) * 2008-03-07 2009-11-05 The Trustees Of Columbia University In The City Of New York Homing in mesenchymal stem cells
GB0805670D0 (en) * 2008-03-28 2008-04-30 Smith & Nephew Increasing the plasticity of stem cells
EP3124601A1 (en) 2008-08-14 2017-02-01 Mesoblast International Sàrl Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions
JP5490803B2 (ja) * 2008-09-22 2014-05-14 ウニヴェルジテート チューリッヒ プロレクトラート エムエヌヴェー 懸滴プレートおよび同懸滴プレートを使用する方法
US20100112031A1 (en) * 2008-10-17 2010-05-06 University Of Virginia Patent Foundation Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
WO2010129775A1 (en) 2009-05-06 2010-11-11 University Of Virginia Patent Foundation Self-illuminated handheld lens for retinal examination and photography and related method thereof
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
EP2609191B1 (en) 2010-08-24 2017-11-22 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
AU2011317203B2 (en) * 2010-10-18 2016-10-20 Sunshine Life Science & Technology Corp. Human multipotent embryonic stem cell-like progenitor cells
EP2655602B1 (en) * 2010-12-22 2019-01-23 The Administrators of the Tulane Educational Fund Method for identifcation and culture of multipotent mesenchymal stem cells with high proliferation potential
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
JP6243839B2 (ja) 2011-06-29 2017-12-06 バイオリストーラティブ セラピーズ， インコーポレイテッド 褐色脂肪細胞の組成物および方法
CN104684493B (zh) * 2012-08-29 2017-10-31 优而美股份公司 用于脂肪组织提取和再注入的仪器
JP6887249B2 (ja) 2013-04-19 2021-06-16 バイオリストーラティブ セラピーズ， インコーポレイテッド ヒト褐色脂肪由来幹細胞およびその使用
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
SG11201707615YA (en) 2013-09-19 2017-10-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US10870852B2 (en) 2015-10-06 2020-12-22 University Of Virginia Patent Foundation Compositions and methods for treating diabetic retinopathy
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
US11541101B1 (en) 2018-10-09 2023-01-03 University Of Virginia Patent Foundation LEMD3 antagonizes TGF-beta-driven Smad2/3 transcription in a stiffness-dependent fashion in both the nucleus and cytosol
CN111518751A (zh) * 2019-11-20 2020-08-11 广东先康达生物科技有限公司 一种体外激活脂肪干细胞转化成原软骨细胞的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5591625A (en) 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
CA2237890C (en) 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
US6200606B1 (en) 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
KR100979664B1 (ko) 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
EP1261694B1 (en) * 2000-02-26 2008-01-16 Artecel, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
KR20040094910A (ko) * 2002-04-03 2004-11-10 아르테셀 사이언스, 인크. 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도
JP2004150624A (ja) * 2002-09-03 2004-05-27 Seiko Epson Corp 磁気軸受装置
KR100534215B1 (ko) 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
US20070116676A1 (en) 2003-12-11 2007-05-24 Naoka Kida Method for three-dimensional cartilage tissue engineering using bone marrow cells in tissue engineering bone marrow cells in simulated microgravity environment
EP1747459A1 (de) * 2004-05-21 2007-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multizelluläre testsysteme
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
EP1805300A4 (en) 2004-09-14 2009-09-09 Univ Columbia DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO THE HEART REPAIR PROMOTING CARDIOVASCULAR CELLS
KR100833612B1 (ko) 2004-12-29 2008-05-30 에프씨비파미셀 주식회사 간엽 간세포로부터 분화된 신경세포를 유효성분으로함유하는 신경계 질환 치료용 약학 조성물
WO2006074075A2 (en) 2004-12-30 2006-07-13 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
EP1909581A4 (en) 2005-07-29 2008-12-31 Univ Virginia Adipose tissue stem cells, perivascular cells and pericytes
US7932084B2 (en) * 2005-09-08 2011-04-26 University Of Virginia Patent Foundation Methods and compositions for growing adipose stem cells
KR100679642B1 (ko) 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
US8592209B2 (en) 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
JP2010505849A (ja) 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
US7787327B2 (en) 2006-11-15 2010-08-31 Baker Hughes Incorporated Cement bond analysis
US20100098739A1 (en) 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

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EP1984488B1 (en) 2017-12-27
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EP1984488A4 (en) 2009-05-13
WO2007089798A2 (en) 2007-08-09
WO2007089798A3 (en) 2008-03-06
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AU2007209870A1 (en) 2007-08-09
CA2641022A1 (en) 2007-08-09

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