KR20080091832A - 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 - Google Patents

중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Download PDF

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KR20080091832A
KR20080091832A KR1020087021183A KR20087021183A KR20080091832A KR 20080091832 A KR20080091832 A KR 20080091832A KR 1020087021183 A KR1020087021183 A KR 1020087021183A KR 20087021183 A KR20087021183 A KR 20087021183A KR 20080091832 A KR20080091832 A KR 20080091832A
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self
cells
asc
cell
organizing mesenchymal
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Korean (ko)
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모쉐 크후르겔
아담 제이. 카츠
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유니버시티 오브 버지니아 페이턴트 파운데이션
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids

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  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
KR1020087021183A 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Withdrawn KR20080091832A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76333306P 2006-01-30 2006-01-30
US60/763,333 2006-01-30

Publications (1)

Publication Number Publication Date
KR20080091832A true KR20080091832A (ko) 2008-10-14

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Application Number Title Priority Date Filing Date
KR1020087021183A Withdrawn KR20080091832A (ko) 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도

Country Status (7)

Country Link
US (1) US8592209B2 (https=)
EP (1) EP1984488B1 (https=)
JP (1) JP2009525044A (https=)
KR (1) KR20080091832A (https=)
AU (1) AU2007209870A1 (https=)
CA (1) CA2641022A1 (https=)
WO (1) WO2007089798A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100322906A1 (en) 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
US8592209B2 (en) 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
JP2010505849A (ja) * 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
JP5509073B2 (ja) 2007-07-12 2014-06-04 ディスクジェニクス ヒト円板組織
US20120100607A1 (en) * 2007-07-12 2012-04-26 Christopher Duntsch Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease
US10633632B2 (en) * 2007-07-12 2020-04-28 Discgenics, Inc. Human disc tissue
US8017390B2 (en) 2007-07-20 2011-09-13 Dongguk University Industry-Academic Cooperation Foundation Method for the preparation of dermal papilla tissue employing mesenchymal stem cells
EP2245141B1 (en) * 2008-01-18 2018-03-14 Regents of the University of Minnesota Stem cell aggregates and methods for making and using
US20110059182A1 (en) * 2008-02-05 2011-03-10 University Of Virginia Patent Foundation Spraying device and related method for cell aggregates and cell aggregate suspension thereof
WO2009134532A2 (en) * 2008-03-07 2009-11-05 The Trustees Of Columbia University In The City Of New York Homing in mesenchymal stem cells
GB0805670D0 (en) * 2008-03-28 2008-04-30 Smith & Nephew Increasing the plasticity of stem cells
WO2010019886A1 (en) 2008-08-14 2010-02-18 Osiris Therapeutics, Inc. Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions
DK2342317T3 (da) * 2008-09-22 2013-03-18 Univ Zurich Prorektorat Forschung Hængende-dråbe-plade
US20100112031A1 (en) * 2008-10-17 2010-05-06 University Of Virginia Patent Foundation Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US8740383B2 (en) 2009-05-06 2014-06-03 University Of Virginia Patent Foundation Self-illuminated handheld lens for retinal examination and photography and related method thereof
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
EP2609191B1 (en) * 2010-08-24 2017-11-22 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
TWI523947B (zh) * 2010-10-18 2016-03-01 尚翔股份有限公司 人類多能性類胚胎幹細胞先驅細胞
CN103261407B (zh) * 2010-12-22 2016-03-02 杜兰教育基金委员会 用于识别和培养具有高度增殖潜能的多能间充质干细胞的方法
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
AU2012275335B2 (en) 2011-06-29 2017-04-20 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
AU2013310961B2 (en) * 2012-08-29 2015-04-02 Euromi S.A. Apparatus for extracting and re-injecting adipose tissue
AU2014253920B2 (en) 2013-04-19 2019-07-04 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
EP3046628B1 (en) 2013-09-19 2019-11-06 The Board of Trustees of the Leland Stanford Junior University Methods and compositions for producing hepatocyte-like cells
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
WO2017062659A1 (en) 2015-10-06 2017-04-13 University Of Virginia Patent Foundation Compositions and methods for treating diabetic retinopathy
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
US11541101B1 (en) 2018-10-09 2023-01-03 University Of Virginia Patent Foundation LEMD3 antagonizes TGF-beta-driven Smad2/3 transcription in a stiffness-dependent fashion in both the nucleus and cytosol
CN111518751A (zh) * 2019-11-20 2020-08-11 广东先康达生物科技有限公司 一种体外激活脂肪干细胞转化成原软骨细胞的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1994000484A1 (en) 1992-06-22 1994-01-06 Young Henry E Scar inhibitory factor and use thereof
US5591625A (en) 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
JP3781433B2 (ja) 1995-11-16 2006-05-31 ケース ウエスターン リザーブ ユニバーシティ ヒト間葉幹細胞の試験管内軟骨形成誘導
US6200606B1 (en) 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
BR0008552A (pt) 1999-03-10 2002-05-07 Univ Pittsburgh Células tronco e redes derivadas de tecido adiposo
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
ES2300320T3 (es) * 2000-02-26 2008-06-16 Artecel, Inc. Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos.
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
AU2003230792A1 (en) 2002-04-03 2003-10-20 Artecel Sciences, Inc. Improvements of adipocytic differentiated adipose derived adult stem cells and uses thereof
JP2004150624A (ja) * 2002-09-03 2004-05-27 Seiko Epson Corp 磁気軸受装置
KR100534215B1 (ko) 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
US20070116676A1 (en) 2003-12-11 2007-05-24 Naoka Kida Method for three-dimensional cartilage tissue engineering using bone marrow cells in tissue engineering bone marrow cells in simulated microgravity environment
US20080064034A1 (en) * 2004-05-21 2008-03-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewand Multi-Cellular Test Systems
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
EP1805300A4 (en) 2004-09-14 2009-09-09 Univ Columbia DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO THE HEART REPAIR PROMOTING CARDIOVASCULAR CELLS
KR100833612B1 (ko) 2004-12-29 2008-05-30 에프씨비파미셀 주식회사 간엽 간세포로부터 분화된 신경세포를 유효성분으로함유하는 신경계 질환 치료용 약학 조성물
EP1830862B1 (en) 2004-12-30 2012-12-19 PrimeGen Biotech LLC Adipose-derived stem cells for tissue regeneration and wound healing
EP1909581A4 (en) 2005-07-29 2008-12-31 Univ Virginia Adipose tissue stem cells, perivascular cells and pericytes
WO2007030652A2 (en) 2005-09-08 2007-03-15 University Of Virginia Patent Foundation Methods and compositions for growing adipose stem cells
KR100679642B1 (ko) 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
US8592209B2 (en) 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
JP2010505849A (ja) 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
US7787327B2 (en) 2006-11-15 2010-08-31 Baker Hughes Incorporated Cement bond analysis
US20100098739A1 (en) 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

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AU2007209870A1 (en) 2007-08-09
EP1984488B1 (en) 2017-12-27
CA2641022A1 (en) 2007-08-09
US8592209B2 (en) 2013-11-26
EP1984488A2 (en) 2008-10-29
WO2007089798A3 (en) 2008-03-06
EP1984488A4 (en) 2009-05-13
JP2009525044A (ja) 2009-07-09
US20090304643A1 (en) 2009-12-10
WO2007089798A2 (en) 2007-08-09

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