KR20080089357A - 17-알릴아미노-17-데메톡시겔다나마이신 다형체 및 제형 - Google Patents

17-알릴아미노-17-데메톡시겔다나마이신 다형체 및 제형 Download PDF

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Publication number
KR20080089357A
KR20080089357A KR1020087015304A KR20087015304A KR20080089357A KR 20080089357 A KR20080089357 A KR 20080089357A KR 1020087015304 A KR1020087015304 A KR 1020087015304A KR 20087015304 A KR20087015304 A KR 20087015304A KR 20080089357 A KR20080089357 A KR 20080089357A
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South Korea
Prior art keywords
aag
polymorph
purified
particle size
formulation
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KR1020087015304A
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English (en)
Korean (ko)
Inventor
피터 제이. 리카리
티모시 리프
루처 피. 드사이
조오지 갈라쪼
그레그 오. 부캐넌
스테펜 윌리암 와트
알렉산더 레드버스 에벌린
로버트 아슬라니안
Original Assignee
코산 바이오사이언시즈, 인코포레이티드
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Publication of KR20080089357A publication Critical patent/KR20080089357A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020087015304A 2005-11-23 2006-11-16 17-알릴아미노-17-데메톡시겔다나마이신 다형체 및 제형 Withdrawn KR20080089357A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73922505P 2005-11-23 2005-11-23
US60/739,225 2005-11-23
US80952706P 2006-05-30 2006-05-30
US60/809,527 2006-05-30
US11/595,005 US7648976B2 (en) 2005-11-23 2006-11-08 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US11/595,005 2006-11-08

Publications (1)

Publication Number Publication Date
KR20080089357A true KR20080089357A (ko) 2008-10-06

Family

ID=38067791

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087015304A Withdrawn KR20080089357A (ko) 2005-11-23 2006-11-16 17-알릴아미노-17-데메톡시겔다나마이신 다형체 및 제형

Country Status (8)

Country Link
US (1) US7648976B2 (enExample)
EP (1) EP1951223A4 (enExample)
JP (1) JP2009517386A (enExample)
KR (1) KR20080089357A (enExample)
AU (1) AU2006318771A1 (enExample)
BR (1) BRPI0618873A2 (enExample)
CA (1) CA2629196A1 (enExample)
WO (1) WO2007061878A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20070167422A1 (en) * 2006-01-18 2007-07-19 Yu Kwok S Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin
GB0612928D0 (en) * 2006-06-29 2006-08-09 Ucb Sa Biological products
EP2121957A4 (en) * 2007-01-26 2010-11-10 Kosan Biosciences Inc MACROLACTAMES OBTAINED BY MODIFIED BIOSYNTHESIS
US20090258869A1 (en) * 2008-02-08 2009-10-15 The Regents Of The University Of California Methods and compounds for treatment or prevention of substance-related disorders
CA3030142A1 (en) * 2016-07-08 2018-01-11 Ranedis Pharmaceuticals, Llc Compositions and methods of treating and/or preventing lysosomal storage diseases and other monogenetic metabolic diseases

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
US5932566A (en) 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5662883A (en) 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
EP1373215B1 (en) 2001-03-30 2006-07-26 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH Geldanamycin derivatives useful for treating cancer
US20040138160A1 (en) 2001-04-27 2004-07-15 Kenichiro Naito Preventive/therapeutic method for cancer
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
DE60225307T2 (de) 2001-09-24 2009-03-19 Conforma Therapeutics Corp., San Diego Verfahren zur herstellung von 17-allyl-amino-geldanamycin (17-aag) und anderer ansamycine
JP2005528390A (ja) 2002-04-10 2005-09-22 コンフォーマ・セラピューティクス・コーポレイション アンサマイシン製剤およびその製造ならびに使用方法
US20060148776A1 (en) 2003-03-13 2006-07-06 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US20050020557A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
US20050054625A1 (en) 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors
US7691838B2 (en) 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
US20050054589A1 (en) 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics
US20050026893A1 (en) 2003-05-30 2005-02-03 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants
US20050020534A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites
US20050020556A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US20050256097A1 (en) 2004-05-11 2005-11-17 Kosan Biosciences, Inc. Pharmaceutical solution formulations containing 17-AAG
WO2006034147A2 (en) 2004-09-16 2006-03-30 Abraxis Bioscience, Inc. Compositions and methods for the preparation and administration of poorly water soluble drugs
US20060067953A1 (en) 2004-09-29 2006-03-30 Conforma Therapeutics Corporation Oral pharmaceutical formulations and methods for producing and using same
CA2596867A1 (en) 2005-02-28 2006-09-08 Kosan Biosciences Incorporated Pharmaceutical formulations containing 17-allylamino-17-demethoxygeldanamycin
US20060228405A1 (en) * 2005-04-07 2006-10-12 Conforma Therapeutics Corporation Phospholipid-based pharmaceutical formulations and methods for producing and using same

Also Published As

Publication number Publication date
JP2009517386A (ja) 2009-04-30
EP1951223A2 (en) 2008-08-06
US20070203110A1 (en) 2007-08-30
AU2006318771A1 (en) 2007-05-31
CA2629196A1 (en) 2007-05-31
WO2007061878A3 (en) 2009-06-04
EP1951223A4 (en) 2010-04-21
US7648976B2 (en) 2010-01-19
BRPI0618873A2 (pt) 2016-09-06
WO2007061878A2 (en) 2007-05-31

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20080623

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid