KR20080033939A - 동결 건조된 형태이거나, 또는 동결 건조될 수 있는 형태인엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 - Google Patents
동결 건조된 형태이거나, 또는 동결 건조될 수 있는 형태인엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 Download PDFInfo
- Publication number
- KR20080033939A KR20080033939A KR1020087000982A KR20087000982A KR20080033939A KR 20080033939 A KR20080033939 A KR 20080033939A KR 1020087000982 A KR1020087000982 A KR 1020087000982A KR 20087000982 A KR20087000982 A KR 20087000982A KR 20080033939 A KR20080033939 A KR 20080033939A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- buffer
- amino acid
- sodium salt
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 204
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 111
- 150000001413 amino acids Chemical class 0.000 claims abstract description 84
- 239000003381 stabilizer Substances 0.000 claims abstract description 39
- 238000004519 manufacturing process Methods 0.000 claims abstract description 12
- 239000004067 bulking agent Substances 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 81
- 239000000872 buffer Substances 0.000 claims description 55
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 34
- 235000001014 amino acid Nutrition 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 29
- 102000001708 Protein Isoforms Human genes 0.000 claims description 25
- 108010029485 Protein Isoforms Proteins 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
- 239000004471 Glycine Substances 0.000 claims description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 12
- 229930006000 Sucrose Natural products 0.000 claims description 12
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- 159000000000 sodium salts Chemical group 0.000 claims description 11
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 9
- 229930195725 Mannitol Natural products 0.000 claims description 9
- 235000010323 ascorbic acid Nutrition 0.000 claims description 9
- 239000011668 ascorbic acid Substances 0.000 claims description 9
- 239000000594 mannitol Substances 0.000 claims description 9
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- 229920005862 polyol Polymers 0.000 claims description 9
- 150000003077 polyols Chemical class 0.000 claims description 9
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 8
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 8
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
- 229960005070 ascorbic acid Drugs 0.000 claims description 8
- 210000004899 c-terminal region Anatomy 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
- 239000004472 Lysine Substances 0.000 claims description 6
- 239000008121 dextrose Substances 0.000 claims description 6
- 235000013922 glutamic acid Nutrition 0.000 claims description 6
- 239000004220 glutamic acid Substances 0.000 claims description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical class [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 5
- 239000007983 Tris buffer Substances 0.000 claims description 5
- 235000004279 alanine Nutrition 0.000 claims description 5
- 159000000007 calcium salts Chemical class 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
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- 230000002378 acidificating effect Effects 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
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- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- 239000008351 acetate buffer Substances 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
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- 239000008363 phosphate buffer Substances 0.000 claims description 3
- 239000007981 phosphate-citrate buffer Substances 0.000 claims description 3
- BWILYWWHXDGKQA-UHFFFAOYSA-M potassium propanoate Chemical compound [K+].CCC([O-])=O BWILYWWHXDGKQA-UHFFFAOYSA-M 0.000 claims description 3
- 239000011734 sodium Chemical class 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical class [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- UPMFZISCCZSDND-JJKGCWMISA-M sodium gluconate Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O UPMFZISCCZSDND-JJKGCWMISA-M 0.000 claims description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims description 3
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 3
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 3
- 150000003431 steroids Chemical class 0.000 claims description 2
- 150000002016 disaccharides Chemical class 0.000 claims 2
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- 239000008365 aqueous carrier Substances 0.000 claims 1
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- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 48
- 210000001508 eye Anatomy 0.000 description 40
- 229960000686 benzalkonium chloride Drugs 0.000 description 35
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 35
- 102000007469 Actins Human genes 0.000 description 24
- 108010085238 Actins Proteins 0.000 description 24
- -1 BAK Chemical class 0.000 description 24
- 239000002674 ointment Substances 0.000 description 24
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 23
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- 210000001519 tissue Anatomy 0.000 description 22
- 239000003755 preservative agent Substances 0.000 description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 19
- 229940024606 amino acid Drugs 0.000 description 18
- 239000003889 eye drop Substances 0.000 description 16
- 239000000499 gel Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 10
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69126105P | 2005-06-17 | 2005-06-17 | |
| US60/691,261 | 2005-06-17 | ||
| US77694706P | 2006-02-28 | 2006-02-28 | |
| US60/776,947 | 2006-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080033939A true KR20080033939A (ko) | 2008-04-17 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087000982A Ceased KR20080033939A (ko) | 2005-06-17 | 2006-06-19 | 동결 건조된 형태이거나, 또는 동결 건조될 수 있는 형태인엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 |
| KR1020087000980A Withdrawn KR20080018268A (ko) | 2005-06-17 | 2006-06-19 | 조직 악화, 부상 또는 손상을 치료하거나 또는 예방하기위한 엘케이케이티이티 및/또는 엘케이케이티엔티 조성물들및 그 방법 |
| KR1020087000983A Withdrawn KR20080021782A (ko) | 2005-06-17 | 2006-06-19 | 엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 및 그 방법 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087000980A Withdrawn KR20080018268A (ko) | 2005-06-17 | 2006-06-19 | 조직 악화, 부상 또는 손상을 치료하거나 또는 예방하기위한 엘케이케이티이티 및/또는 엘케이케이티엔티 조성물들및 그 방법 |
| KR1020087000983A Withdrawn KR20080021782A (ko) | 2005-06-17 | 2006-06-19 | 엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 및 그 방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US20090131313A1 (https=) |
| EP (4) | EP1896050A4 (https=) |
| JP (3) | JP2008543878A (https=) |
| KR (3) | KR20080033939A (https=) |
| CN (1) | CN105106931A (https=) |
| AU (3) | AU2006261157A1 (https=) |
| CA (3) | CA2612522A1 (https=) |
| HK (1) | HK1218248A1 (https=) |
| IL (4) | IL187522A0 (https=) |
| MX (3) | MX2007015958A (https=) |
| WO (3) | WO2006138709A2 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160143610A (ko) | 2016-11-29 | 2016-12-14 | 주식회사 지트리파마슈티컬 | 티모신 베타 4 를 함유하는 제형 |
| KR20170021667A (ko) | 2015-08-18 | 2017-02-28 | 주식회사 지트리비앤티 | 티모신 β4를 유효성분으로 포함하는 신경영양성각막염 치료용 조성물 |
| KR20170021745A (ko) | 2015-08-18 | 2017-02-28 | 주식회사 지트리비앤티 | 티모신 β4 및 시트르산을 유효성분으로 포함하는 각막 손상 예방 또는 치료용 조성물 |
| KR20170041109A (ko) | 2015-10-06 | 2017-04-14 | 주식회사 지트리비앤티 | 티모신 β4를 포함하는 안약의 제조방법 |
| US10406208B2 (en) | 2014-10-22 | 2019-09-10 | G-Treebnt Co., Ltd. | Composition containing thymosin beta 4, and pharmaceutical formulation comprising same |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2718774A1 (en) * | 2008-03-17 | 2009-12-17 | Regenerx Biopharmaceuticals, Inc. | Improved beta thymosin fragments |
| CN101297965B (zh) * | 2008-06-16 | 2011-01-05 | 浙江省中医药研究院 | 胸腺肽β4在制备防治支气管哮喘药物中的应用 |
| WO2011044589A2 (en) * | 2009-10-09 | 2011-04-14 | Board Of Regents, The University Of Texas System | Photokinetic ocular drug delivery methods and apparatus |
| WO2012126047A1 (en) * | 2011-03-18 | 2012-09-27 | Adistem Ltd | Agent and method for treating pain and reducing inflammation |
| DK2819682T3 (en) | 2012-03-01 | 2017-08-21 | Firststring Res Inc | TOPICAL GELLS CONTAINING ALPHA-CONNEXIN C-TERMINAL (ACT) PEPTIDES |
| EP2698162A1 (en) | 2012-08-15 | 2014-02-19 | Credentis AG | Method for producing a composition for treating a tooth lesion |
| AU2014345802B2 (en) * | 2013-11-07 | 2018-01-25 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Storage stable lyophilized tripeptide formulations |
| CA2942035A1 (en) | 2014-03-12 | 2015-09-17 | University Of Virginia Patent Foundation | Compositions and methods for treating eye infections and disease |
| MA41299A (fr) * | 2014-12-30 | 2017-11-07 | Axim Biotechnologies Inc | Solutions ophtalmiques pour le traitement du glaucome et de la conjonctivite |
| CA3031069A1 (en) * | 2016-07-18 | 2018-01-25 | Regentree, Llc | Methods of treating dry eye syndrome |
| KR20250023579A (ko) * | 2017-02-21 | 2025-02-18 | 티얼솔루션즈, 인크. | 안정한 펩타이드 조성물 |
| KR102340750B1 (ko) * | 2017-03-03 | 2021-12-21 | 에이치엘비테라퓨틱스 주식회사 | 티모신 베타 4를 유효성분으로 포함하는 안정화된 외용 제제 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10406208B2 (en) | 2014-10-22 | 2019-09-10 | G-Treebnt Co., Ltd. | Composition containing thymosin beta 4, and pharmaceutical formulation comprising same |
| KR20170021667A (ko) | 2015-08-18 | 2017-02-28 | 주식회사 지트리비앤티 | 티모신 β4를 유효성분으로 포함하는 신경영양성각막염 치료용 조성물 |
| KR20170021745A (ko) | 2015-08-18 | 2017-02-28 | 주식회사 지트리비앤티 | 티모신 β4 및 시트르산을 유효성분으로 포함하는 각막 손상 예방 또는 치료용 조성물 |
| KR20170041109A (ko) | 2015-10-06 | 2017-04-14 | 주식회사 지트리비앤티 | 티모신 β4를 포함하는 안약의 제조방법 |
| US10744088B2 (en) | 2015-10-06 | 2020-08-18 | G-Treebnt Co., Ltd. | Method for preparing ophthalmic preparation containing thymosin beta-4 |
| KR20160143610A (ko) | 2016-11-29 | 2016-12-14 | 주식회사 지트리파마슈티컬 | 티모신 베타 4 를 함유하는 제형 |
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