KR20080012457A - Composition for treating obesity and constipation - Google Patents

Abstract

A composition comprising medicinal herbs is provided to treat obesity and constipation, reduce side effects of long term dosage, improve treatment effects and economical efficiency, and increase favorite of dosage by removing bad smell and taste. A composition for treating obesity and constipation comprises 0.5-2 parts by weight of adlay, 0.5-2 parts by weight of Atractyodis Rhizoma, 0.5-2 parts by weight of Aloe arborescens, 0.25-1 part by weight of Rheum palmatum L., 0.05-0.5 parts by weight of honey and 0.01-0.05 parts by weight of propolis, and is formulated as tablet, pill, capsule, granule, solution, suspension or emulsion; or 1 parts by weight of adlay, 1 parts by weight of Atractyodis Rhizoma, 1 parts by weight of Aloe arborescens, 0.5 part by weight of Rheum palmatum L., 0.17 parts by weight of honey and 0.03 parts by weight of propolis. Further, the composition is formed as tablet, pill, capsule, granule, solution, suspension or emulsion.

Description

Composition for treating obesity and constipation

The present invention relates to a herbal composition effective for improving or treating constipation and abdominal obesity.

In recent years, constipation of primary school students as well as office workers is increasing. Constipation is becoming a social problem beyond a medical problem in that it can interfere with the healthy growth of the child's mind and body.

Medically, constipation generally refers to a condition in which feces remain in the large intestine for a long time. In general, 1) the number of bowel movements is less than twice a week, 2) the weight of the stool is less than 30 ~ 35g per day, 3) at least one of the four bowel movements, hard and thick stools, or 4) at least one of four bowel movements In this case, two or more of the five items last more than three months, such as excessive strength is needed, and 5) one or more out of four bowel movements are felt as if the bowel movement is left after bowel movement.

The causes of constipation vary, but 80% of people who experience constipation are often more than just functional. Types of constipation due to these functional abnormalities are divided into laxative constipation, rectal constipation and constipation constipation. Atonic Constipation is a condition in which the bowel is weakened and relaxed so that the stool is not pushed toward the anus and is contained in the intestine.It is uncomfortable even if you do not see the stool for a few days. This may be due to aging of the colon, lack of strength, or lack of thyroid hormone, or the continued use of parasympathetic drugs. It mainly occurs in the elderly or people with poor mobility, weak constitution, people with gastric or colon sewage. Proctogenous constipation is when the stool comes down to the rectum but no longer comes down due to the rectum. The workplace is full of stools, but it's not hesitant, no matter how hard you go to the toilet, the stools will not come out. The cause is caused by bad bowel habits. In other words, by habitually suppressing constipation, the senses become dull and the sensory function is lost, resulting in rectal constipation. If the stool stays in the workplace for a long time, all the moisture is absorbed and hard stools such as stony remains remain and the stools are not seen. If this is repeated, the stool is stretched so that there is no desire to see the stools in the workplace. Spastic constipation is a type of irritable bowel syndrome. Constipation caused by convulsions in the part of the intestine that prevents the stools from moving forward. I want to see the stool is strong, but the stools do not come out well, and the thin and thin stools may come out in some cases, or in some cases, like goat dung. It also feels bloated, full of gas, and uncomfortable. Convulsive constipation occurs in people with stress, gastroduodenal ulcers, gallstones, chronic pancreatitis and chronic appendicitis.

The remaining 20% of constipation patients are congenital causes of colorectal disease or anus abnormalities, such as colorectal obstruction caused by cancer, colonic diverticulosis, rectal wall relaxation, rectal disorders, hemorrhoids, anus and post-abdominal disorders. Constipation can come, and other congenital factors, such as the length of the large intestine and twisted constipation can also occur. In this case, the main cause of treatment first, constipation is solved.

Many secondary diseases are caused by constipation. Once constipation occurs, the metabolism of harmful substances released into the body is not properly done. As blood circulation is poor, the body's toxicity remains intact on the skin, causing discomfort such as swelling, acne, blemishes, and aging. Headache, loss of appetite, abdominal discomfort, insomnia, back pain, hemorrhoids, obesity, colonic diverticosis and colorectal cancer can occur. Toxins that need to be excreted stay in the body, causing blood circulation disorders and circulatory diseases such as atherosclerosis.

Most of the constipation drugs on the market to solve constipation are drugs for laxative constipation, and according to the mechanism of action, it can be divided into four types of softener, swelling agent, saline relieving agent, irritant laxative. Softening agents such as mineral oil or ducocetate are poorly absorbed by the gastrointestinal tract and soften hardened stools to cause bowel movement. Side effects may cause absorption of fat-soluble vitamins. Strain relievers, such as chaff blood, combine with water and ions in the large intestine to soften the stool and increase the volume to promote bowel movement. Salt relieving agents, such as magnesium sulfate and lactulose, are salts that act as osmotic pressure-activated substances in the intestine to prevent water absorption from the intestinal wall, thereby keeping the water content of the stool easy to defecate. However, the salt relief agent has a disadvantage that can cause diarrhea. Stimulant laxatives, such as bisacryl, are drugs that inhibit the absorption of water and electrolytes in the intestine and enhance bowel movements to promote bowel movement. However, this irritant can also cause diarrhea if the action is excessive.

Herbal medicines conventionally used for the treatment of constipation include Tongyutang, Samhwasan, Doinseunggitang, Dangguiseunggitang, Samatang, Bangpungtongseongsan, Mazainhwan, Jecheonjeon, Yunheum-eum, among them. There is a problem such as not being able to, or the effect is unclear.

Obesity, on the other hand, refers to a condition in which the body's fat is excessively accumulated, and is a complex syndrome caused by various causes such as genetic, nutritional, environmental, and social factors. In other words, when the calorie intake exceeds the energy consumption, the remaining energy is converted to fat and stored in fat cells, which in turn causes obesity. Obesity is divided into abdominal obesity (upper body obesity, central obesity) and lower body obesity (peripheral obesity), depending on the distribution of fat in the body, abdominal obesity in the case of excess fat accumulated in the abdomen or abdominal cavity than other parts of our body This is called. Particularly, the reason for distinguishing abdominal obesity is that adult obesity, such as diabetes, hypertension, hyperlipidemia and atherosclerotic cardiovascular disease (stroke, ischemic heart disease) is more likely to occur in abdominal obesity than lower obesity. Abdominal obesity cannot be diagnosed by body mass index or bioresistance, which is a common measure of obesity, but uses visceral fat / subcutaneous fat area ratio using waist / hip circumference ratio or computed tomography. The waist / buttock ratio is the easiest way to diagnose abdominal obesity, by standing out, measuring the smallest circumference of the waist, the largest circumference of the buttocks, and then dividing the waist circumference by the hip circumference. In general, if more than 0.9 in men, 0.8 or more in women is diagnosed as abdominal obesity. Control the release of such neurohormones serotonin related to act on the fat absorption inhibitor, a cerebral appetite backbone, such as the current Xenical As the anti-obesity agent which is commercially available ^® satiety by rideoktil for the treatment of obesity by controlling the amount of food by doing feel fast filling ^® And other drugs. However, the drugs are quite expensive and there is a difficulty that can not be easily taken by the general public.

As described above, constipation and abdominal obesity is not only a pain caused by itself, but also a disease that must be treated for the prevention of secondary symptoms, but conventional constipation or obesity treatment agent is expensive or difficult to take for a long time.

Therefore, there is no concern about side effects even if taken for a long time, there is a clear therapeutic effect against constipation and abdominal obesity, and economical herbal medicines are required. In addition, since general herbal medicines have a problem of poor palatability due to already and off-flavor, there is a need for herbal medicines with excellent palatability.

It is an object of the present invention to provide an herbal composition that is effective against constipation and abdominal obesity, has no side effects and has increased palatability.

The present invention to achieve the above object,

Effective in improving or treating constipation and abdominal obesity,

Provided are compositions comprising barley, crops, presbytery, rhubarb, honey and propolis.

Hereinafter, the present invention will be described in detail.

Compositions effective for the treatment of constipation and abdominal obesity of the present invention, the main ingredients are yulmu, creation, presbytery, rhubarb, honey and propolis, each of the main components will be described as follows.

Coix lacryma - jobi LINNE ) is called medicinal herb (재 仁) in the name of Chinese herbal medicine, and is a mature species of Yulmu, an annual or perennial herb belonging to the family of rice. It is sweet and calm, cool in nature, and works on the spleen, stomach and lungs. Yulmu is a medicinal herb that consumes a lot of tea, and Yulmu has a good effect on eliminating abnormally accumulated water in the body. In addition, the spleen and stomach to the effect that combines the weakness of the spleen is used for various symptoms of stagnation of water. It also lowers the heat and eliminates inflammation and pus. Treat edema, poor urine symptoms, diarrhea, swelling and slow muscle movement, and lung or intestinal abscesses.

Atractylodes japonica KOIDZ ) is a root stem of perennial herbaceous herbaceous grass, which is bitter and tastes warm and acts on the spleen, stomach and liver. Creation is a representative herb that eliminates moistness. When moisture accumulates in the stomach, symptoms such as indigestion, diarrhea, and bloating occur, and creation helps to remove these moistures. In addition, it acts on the external perception, it is also used to sweat, cold, etc. because it stimulates sweating. It also works to brighten the eyes by acting on the liver. All diseases caused by low body temperature and fever caused by illness, fever, stroke, dysuria, conjunctivitis, high blood pressure, dizziness, old people write asthma.

Presbytery ( Aloe) vera LINNE , Aloe arborescens AIV . ) Is a botanical herb, perennial herbaceous genus of the family Liliaceae, tastes bitter and cold, and has no poison and acts on the liver and large intestine. Lower the heat of the liver is effective for constipation and parasites. Antibacterial action so that the inflammation of the stomach and intestines to normalize the function of the stomach and make the activity of the intestines good. It has an antibacterial effect, it blocks ultraviolet rays, whitens the skin, and also has antifungal action. Delivers amazing moisturizing power to the skin to act on the body for immunoregulation and anticancer activity. People with darker faces should apply aloe juice frequently with lotion.

Rheum officinale BAILLON , Rheum palmatum LINNE ) is a stem of perennial plant of perennial plant of barphyleaceae. It is bitter and cold and has no poison and acts on spleen, stomach, large intestine, liver and symphony. It defecates what is accumulated in the intestinal tract to remove blood and waste products, cools the fever, and is used for dysmenorrhea, degenerative arthritis, fever, and fever with fever, each, swelling, and burn.

Honey is a saccharide obtained from the honeycomb of honeybees and oriental honeybees belonging to the honeybee family. The honey tastes sweet and the property is not deviated from one side and is flat. It acts on the lungs, spleen and large intestine. The stomach and lungs to replenish the energy, antitussive action, detoxification and analgesic, faeces have a good effect. It also increases body's resistance, heals wounds quickly, has antibacterial effect, and is good for fatigue recovery and hangover removal.

Propolis is a product made by mixing bees and enzymes with a substance such as a resin extracted from various plants for the survival and reproduction of bees. Its main effects are anti-inflammatory, antioxidant and Immune-boosting action.

The composition according to the present invention is preferably 0.5 to 2 parts by weight, 0.5 to 2 parts by weight, 0.5 to 2 parts by weight of preskins, 0.25 to 1 parts by weight of rhubarb, 0.05 to 0.5 parts by weight of honey and 0.01 to 0.05 parts by weight of propolis. Parts, more preferably 1 part by weight, 1 part by weight, 1 part by weight, 1 part by weight of presbytery, 0.5 part by weight of rhubarb, 0.17 part by weight of honey and 0.03 part by weight of propolis.

As shown in the following Experimental Example 1 and Table 3, the composition of the present invention, when administered to 50 adults with constipation symptoms, the frequency of bowel movement was improved regularly about once every 1 to 2 days, the thickness and appearance of the stool It was improved, and there was no remnant after defecation, and the constipation symptoms were improved and the treatment effect was excellent.

In addition, as shown in Experiment 3, the composition of the present invention was effective in treating abdominal obesity, since an average reduction of 30-40% was observed when measuring waist / buttock ratio after 50 months in 50 adults. It was confirmed.

The composition of the present invention may be prepared in a suitable formulation using a pharmaceutically inert organic or inorganic carrier. Examples of such formulations may be prepared in the form of tablets, coated tablets, pills, dragees, hard or soft capsules, solutions, suspensions or emulsions, but are not limited to the formulations listed above. For example, each component may be combined and heated at 80 to 100 ° C., followed by extraction to prepare a liquid phase, or the liquid composition may be freeze-dried to prepare a powder. Alternatively, each component may be dried and then powdered and then taken as a pill.

It is preferable that the composition of the present invention be a tablet or a pill because the amount is preferably adjusted according to the condition of the patient. In the embodiment of the present invention, each component was dried and then powdered and used as pills.

If the formulations are tablets, coated tablets, dragees and hard capsules, lactose, corn starch or derivatives thereof, talc, stearic acid or salts thereof can be used. Also, when the formulation is a soft capsule, polyols of vegetable oils, waxes, fats, semisolids and liquids can be used. In the case of solution or syrup form, water, polyols, glycerol, vegetable oils and the like can be used. Other preservatives, stabilizers, wetting agents, emulsifiers, solubilizers, sweeteners, colorants, osmotic pressure regulators, antioxidants, and the like can be formulated further.

The method of administration can be easily selected depending on the dosage form and is usually oral. The dosage may vary depending on the weight, severity, sex, and age of constipated patients, but in general, it is preferable to administer 5.0-10.0 g per day for healthy adult males (70 kg basis). The number of doses can also be easily adjusted according to the weight, severity, sex, and age of constipation patients.

The present invention will be described in more detail with reference to the following Examples. However, the following examples are only presented to aid the understanding of the present invention, and the present invention is not limited to the following examples.

< Example  1>

1,200 g of dried radish dried and powdered in the shade, and 1,200 g of dried and powdered in the shade, 1,200 g of dried and powdered preskins in the shade and 600 g of dried and powdered rhubarb in the shade Mix and the mixture was aged at 7 ° C. for 48 hours. 200 g of honey and 30 g of propolis were further added to the mixed powder, licorice powder was added as an excipient, and then molded into a spherical ring and dried to prepare a pill of the composition of the present invention. The dry weight of the grains of the pill prepared as described above is 0.1 ± 0.01 g, and a composition as shown in Table 1 below.

TABLE 1

division Parts by weight Remarks Rule 1.00 Dry weight Creation 1.00 Dry weight craftiness 1.00 Dry weight rhubarb 0.50 Dry weight honey 0.17 Liquid Propolis 0.03 Liquid

< Comparative example  1>

Except for Yulmu, Produce and Propolis in the composition of Example 1, the method disclosed in Example 1 except for using licorice powder as an excipient to have the same range of weight as the pill prepared in Example 1 In the same manner as in prepared a pill of the comparative composition. The composition of Comparative Example 1 is a composition as shown in Table 2 below.

TABLE 2

division Parts by weight Remarks craftiness 1.00 Dry weight rhubarb 0.50 Dry weight honey 0.17 Liquid

< Experimental Example  1> improvement of constipation and confirmation of treatment effect

After selecting the subjects with constipation symptoms of a total of 50 people each of 25 men and women in their 20s and 30s, the pill of the present invention prepared as in Example 1, 2.5g (25 pills based on the pill standard of Example 1) once for breakfast, Three times a day 15 minutes after lunch and dinner. The test period was 15 days, and the panel members were allowed to live as usual within the test period, and each panel responded by filling out the questionnaire every day about the number of bowel movements, stiffness of the stool, the appearance of the stool, and the freshness after the bowel movement. The results of the questionnaire responses are summarized and averaged and shown in Table 3.

<Comparison Experimental Example  1>

In order to compare the composition of the present invention with a composition consisting of presbytery, rhubarb and honey, a comparative test was carried out with pills of the composition of Comparative Example 1. 2.5 g of the pill of Comparative Example 1 based on the single oral dose (25 pills of the pill standard of Comparative Example 1, and the dosage of Example 1 and Comparative Example 1 were the same with respect to rosacea, rhubarb and honey) The test was conducted in the same manner as in Experimental Example 1. The questionnaire answers, which are the results of the implementation of the Comparative Experimental Example 2, are synthesized and the average is shown in Table 3.

< Experimental Example  2> palatability evaluation

On the 15th day, which is the last day of the test of Experimental Example 1 and Experimental Example 2, palatability or flavor was determined by ingesting pills of the compositions of Example 1 and Comparative Example 2, and sensory evaluation was performed. The questionnaire answers, which are the result of the test, are summarized and averaged in Table 3.

TABLE 3

 division Bowel movements ^{1 )} Hardness of stools ^{2 )} Appearance of feces ^{3 )} Refreshing after defecation ^{4 )} Palatability ^{5 )} Example 1 Before administration 2 1.3 1.9 -0.4  0.8 After administration 13 -1.2 -0.5 One Comparative Example 1 Before administration 2 1.3 1.9 -0.4  0.2 After administration 7 -0.5 -2 0.5

1) Number of bowel movements: 15 days of bowel movements

2) Stiffness of the sides: -2 (very soft), -1 (soft), 0 (usually), 1 (hard), 2 (very hard)

3) Stool appearance: -3 (water form), -2 (mud form), -1 (quality dough), 1 (cylindrical form), 2 (round form), 3 (hard form)

4) Refreshment after defecation: -1 (unpleasant), 0 (normal), 1 (fresh)

5) Palatability: -1 (unsatisfied), 0 (medium), 1 (satisfied)

As a result of the experiment, as shown in Table 3, the bowel movement becomes comfortable after ingesting the composition of the present invention and feels refreshed after bowel movement, the bowel movement that was not constant about twice in 15 days in the frequency of bowel movement, 1 to 2 days The circuit was relatively regular, and the firmness and appearance of the stool were also greatly improved, confirming that the composition of the present invention was effective in improving or treating constipation. In addition, compared to the comparative composition consisting of presbyopia, rhubarb and honey it was confirmed that the bowel effect and palatability significantly increased to give the user satisfaction without side effects.

< Experimental Example  3>-Confirm abdominal obesity treatment and improvement effect

25 adult males with a waist / hip circumference ratio of 0.9 or more and 25 adult females with 0.8 or more were administered and administered in the same manner as in Experiment 1 except that the administration period was 3 months. Before starting the experiment, the average waist / hip circumference ratio of the adult male was 1.3, and the average waist / hip circumference ratio of the adult female was 1.2, which was a state of abdominal obesity, but after 3 months of administration of the composition of the present invention. One average waist / hip circumference ratio was 0.8 and 0.7, respectively, and the composition of the present invention was found to be very effective in improving and treating abdominal obesity.

The above Examples and Experimental Examples are only added once again to illustrate the present invention, and the scope of protection of the present invention is not limited to the Examples and Experimental Examples.

As described above, the composition of the present invention is effective against constipation and abdominal obesity, has no side effects, and has excellent palatability, and thus can be economically consumed without rejection or discomfort.

Claims (4)

Composition for the treatment of constipation or abdominal obesity, including barley, creation, presbytery, rhubarb, honey and propolis. The method according to claim 1, comprising 0.5 to 2 parts by weight, 0.5 to 2 parts by weight, 0.5 to 2 parts by weight of presbytery, 0.25 to 1 parts by weight of rhubarb, 0.05 to 0.5 parts by weight of honey and 0.01 to 0.05 parts by weight of propolis. Composition. The composition of claim 1 comprising 1 part by weight, 1 part by weight, 1 part by weight, 1 part by weight of presbytery, 0.5 part by weight of rhubarb, 0.17 part by weight of honey and 0.03 part by weight of propolis. The composition of claim 1, wherein the composition is formulated into one selected from the group consisting of tablets, pills, capsules, granules, solutions, suspensions and emulsions.