CN102949457A - Pure traditional Chinese medicinal composition for treating leucoderma and preparation method thereof - Google Patents

Pure traditional Chinese medicinal composition for treating leucoderma and preparation method thereof Download PDF

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Publication number
CN102949457A
CN102949457A CN2012104814527A CN201210481452A CN102949457A CN 102949457 A CN102949457 A CN 102949457A CN 2012104814527 A CN2012104814527 A CN 2012104814527A CN 201210481452 A CN201210481452 A CN 201210481452A CN 102949457 A CN102949457 A CN 102949457A
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China
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parts
treatment
medicinal composition
leukodermic
weight
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CN2012104814527A
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Chinese (zh)
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唐永红
钱博
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Xian Taikomed Medical Technology Co Ltd
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Xian Taikomed Medical Technology Co Ltd
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Priority to CN2012104814527A priority Critical patent/CN102949457A/en
Publication of CN102949457A publication Critical patent/CN102949457A/en
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Abstract

The invention discloses a pure traditional Chinese medicinal composition for treating leucoderma and a preparation method thereof. The medicinal composition comprises the following medicinal raw materials in part by weight: 35 parts of fructus psoraleae, 30 parts of semen brassicae, 15 parts of angelica and 15 parts of fig leaf. The pure traditional Chinese medicinal composition is oral solution which is prepared according to a compatible regulation of a herbal prescription. The aim of treating leucoderma is fulfilled by dispersing immature phlegm and dredging blockage of blood vessels. Compared with the current pills and capsules which have the related effects, the medicinal composition has the advantages of small dosage, good mouthfeel, convenience in taking, relatively high absorption speed, high bioavailability, stable quality, simple production process and the like.

Description

A kind of leukodermic pure Chinese medicine composition and preparation method thereof that is used for the treatment of
Technical field
The invention belongs to field of pharmaceutical technology, particularly a kind of leukodermic pure Chinese medicine composition and preparation method thereof that is used for the treatment of.
Background technology
Vitiligo (Vitiligo) is a kind of common skin diseases take the local skin depigmentation as main clinical manifestation.Primary disease is to occur the day after tomorrow. can start from any age, this disease of neonate onset of 3 days of report birth be arranged, but see at most the youth, someone adds up, and closely half was fallen ill before 20 years old among the patient.Clinical manifestation is that skin lesion place pigment takes off mistake fully, is creamy white.Clear from the spot edge boundary, pigment increases on the contrary, and the hair in the white macula is as seen decolouring also.Clinical pathology is shown as epidermis and obviously lacks melanocyte and melanocyte oral liquid, and basal layer often lacks the melanocyte of the dopa stain positive fully.
Vitiligo mainly occurs in and exposes and the friction position, a kind of common part or general posteriority depigmentation disease, prevalence is 0.1%-2% approximately, about the etiology of primary disease heredity, autoimmune, spirit and nerve, melanocyte autoclasia and trace element deficiency etc. is arranged.The more saying of this sick etiology and pathology of modern medicine bound pair mainly contains: the melanocyte growth factor lacks theory; The neuro chemistry factor theory; Theory of autoimmunity; Relevant with local skin damage and long-term compressing friction, melanocyte autoclasia theory; Relevant with inherited genetic factors; Relevant with nutritional disorder etc.Drink, psychentonia, diet are irregular, the happiness food is pungent, wound, often exposed to pesticides, contact paint raw materials can be used as leukodermic independent hazard factor.Solar radiation, often eat vegetable and fruit and may be negative with vitiligo.
Vitiligo has become a kind of common disease at present, and any age all can fall ill, and M-F about equally.Leukodermic sickness rate is approximately 1%~2%, accounts for 3%~4% in all diseases of department of dermatologry.Its sickness rate with the area, the ethnic group colour of skin is different and different.The darker crowd's sickness rate of general colour is higher, as at Indian group's sickness rate up to 4%, and the U.S. is less than l%, Denmark then is 0.38%.The yellow is between white people and black race, and sickness rate is 0.09%-0.54% in the population of China, and the city is a little more than the rural area.
Summary of the invention
Purpose of the present invention aims to provide a kind of leukodermic pure Chinese medicine composition and preparation method thereof that is used for the treatment of, and by dispersing the immaturity phlegmatic temperament, dredging blood vessel blocks, and the double wind dispelling of Shugan Yishen and battalion is evil, reaches the leukodermic purpose of healing.Its taking dose is little, mouthfeel good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.
Technical scheme of the present invention is: design a kind of leukodermic pure Chinese medicine composition that is used for the treatment of, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 35 parts of Fructus Psoraleaes, 30 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of common fig leaf juice.
Described a kind of preparation method that is used for the treatment of leukodermic pure Chinese medicine composition, it may further comprise the steps:
1) by following weight ratio weighting raw materials: 35 parts of Fructus Psoraleaes, 30 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of common fig leaf juice;
2) raw material of above-mentioned weight portion is added 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;
3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;
4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;
5) add that to account for gross weight be 1% stevioside, taste masking;
6) adding distil water filters to total amount, packing, and sterilization gets final product.
Advantage of the present invention is: in conjunction with the theoretical prescription of modern Chinese medicine, disperse the immaturity phlegmatic temperament according to the traditional prescription method of the traditional Chinese medical science, and the dredging blood vessel retardance, the double wind dispelling of Shugan Yishen and battalion is evil, reaches to cure leukodermic purpose.The monarch drug Fructus Psoraleae is hot, bitter, warm in the drug regimen, returns kidney, spleen channel, is conventional Chinese medicine.Head sees " Kaibao Bencao ", has reinforcing the kidney and supporting YANG, the effect of improving inspiration by invigorating kidney-QI, antidiarrheal.The successive dynasties traditional Chinese medical science is usually used in controlling suffers from a deficiency of the kidney, cold diarrhea, and the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed, and external treatment is used for dermatosis, vitiligo, alopecia etc., is recorded in volume by Chinese Pharmacopoeia version in 2005.Semen Sinapis Albae is warm in nature, returns lung meridian, and warming the lung to eliminate phlegm is arranged, promoting the circulation of QI eliminating stagnation, the effect of removing obstruction in the collateral to relieve pain.Clinical application range is wider, both oral administrations, but again external, pharmacological research shows: the Semen Sinapis Albae external can produce local excitation (foaming), cause the direct chemistry " infringement " of skin, the Transdermal absorption of one side significantly increasing medicament, the aspect causes " secondary lesion " (chafing, pigment cell's propagation, pigmentation) in addition, and these " infringements " but become the leukodermic good method for the treatment of.Common fig leaf juice is hidden sweet, little suffering, and property is flat, mild toxicity.Clearing away damp-heat is separated sore, reducing swelling and alleviating pain.Cure mainly diarrhea due to damp-heat, leukorrhagia, hemorrhoid.Carbuncle pain, scrofula.Effective ingredient is psoralen, and this material has significant photosensitization.Radix Angelicae Sinensis has the merit of blood-nourishing skin-moisturizing, dispelling wind for relieving itching, is usually used in treating the cards such as chronic urticaria, pityriasis rosea, psoriasis, chronic eczema, skin pruritus, prurigo and other drying property dermatosiss and belongs to the blood-deficiency and wind-dry person.Use in recent years the intractable dermatosiss such as angelica for treating vitiligo, alopecia areata, also obtained preferably effect.Each composition all plays a role from different aspects to the treatment vitiligo.Embodiment of the invention taking dose is little, mouthfeel good, taking convenience absorb very fast, bioavailability is high, steady quality, production technology are simple.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment 1
Be used for the treatment of leukodermic pure Chinese medicine composition preparation method it may further comprise the steps:
1) by following weight ratio weighting raw materials: 35 parts of Fructus Psoraleaes, 30 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of common fig leaf juice;
2) raw material of above-mentioned weight portion is added 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;
3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;
4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;
5) add that to account for gross weight be 1% stevioside, taste masking;
6) adding distil water filters to total amount, packing, and sterilization gets final product.
The below is that 1 one kinds of the embodiment of the invention are used for the treatment of leukodermic pure Chinese medicine composition and are used for the treatment of leukodermic clinical observation:
1 data and method
1.1 physical data
Patients with vitiligo 100 examples that selection is received treatment voluntarily, male 50 examples, women 50 examples, the course of disease 1 month-20 years.Be divided at random treatment group 1, treatment group 2, treatment group 3, matched group, every group of 25 examples; Each is organized the patient age symptom and consists of without significant difference.Has comparability (P〉0.05).
1.2 Therapeutic Method
The treatment group Primary Care is consistent, and matched group is not taken medicine.The treatment group 1 usefulness embodiment of the invention 1, each 5ml, 3 times on the one.Treatment group 2 usefulness are driven Bai Babu phase sheet, Xinjiang Hua Kang Pharmaceutical, one time 5,3 times on the one; Treatment group 3 is used compound kaliziranding, and the Xinjiang New Times, Pharmaceutical Co produced, every 6~9g that takes, 2 times on the one.
2 results
2.1 curative effect determinate standard
Criterion of therapeutical effect (draft) according to national pigment disease group formulation: recovery from illness: white macula all disappears, and recovers the normal colour of skin; Produce effects: white macula partly disappears or dwindles, the area that recovers the normal colour of skin account for the skin lesion area more than; Effectively: white macula partly disappears or dwindles, the area that recovers the normal colour of skin account for the skin lesion area more than, but in; Invalid: white macula is unchanged or dwindle, the area that recovers the normal colour of skin account for the skin lesion area 10% in.
2.2 therapeutic outcome
Cure Produce effects Effectively Invalid Effective percentage
Contrast 25 0
Treatment group 1 14 6 4 1 96%
Treatment group 2 10 7 3 5 80%
Treatment group 3 9 9 3 4 84%
3 discuss
Chinese medicine is with a long history to leukodermic understanding, and according to theory of Chinese medical science, the vitiligo pathogenic factor is the coefficient result of internal and external reasons, endogenous cause of ill is how relevant with zang-fu disharmonies such as liver, kidney, lung, spleens, how because of internal injury caused by excess of seven emotions, and functional activity of QI being not smooth, feel again ailment said due to cold or exposure, fight in skin, can cause depression of liver-QI, impairment of dispersing and descending function of the lung, cause QI and blood disloyal, battalion defends and becomes estranged and failure of skin and muscle to be nourished, with the passing of time transverse invasion of hyperactive liver-QI and violate spleen, incoordination between the spleen and stomach occurs, rheumatism is held back in meridians; The liver and the kidney have a common source, and liver is thanks to suffered from a deficiency of the kidney, and battalion defends without fluent machine, and QI and blood can not the nutrition skin, and with the passing of time deficiency of liver-blood, kidney essense are lost, formation interior-heat pent-up body constitution.Exopathogenic factor mostly is ailment said due to cold or exposure and damp is taken advantage of a weak point, and invades skin, causes the part qi-blood disharmony, blockage of main and collateral channels, and skin must not be warm.Interior foreign minister holds concurrently, and yin and yang qi and blood disorder, skin and hair lose supports, and the blackening depigmentation forms white macula.Generally speaking, the traditional Chinese medical science thinks that the relation of leukodermic etiology and pathogenesis and wind, heat, lung, kidney, gas, blood is very close.Secondly, also inseparable with the pathogenic origin cause of formation of white scar phoenix such as dry, wet, the heart, liver, expectorant, void etc.Adopt Chinese medicine to import the drug treatment vitiligo, disperse the immaturity phlegmatic temperament, the dredging blood vessel retardance, Shugan Yishen and the battalion wind dispelling of holding concurrently is evil, internal and external application, reinforcement and elimination in combination, giving consideration to both the incidental and fundamental had so both guaranteed curative effect, was difficult for the purpose of recurrence after reaching again more.And then illustrate that embodiment 1 affiliated prescription is reliably effective in this invention.

Claims (2)

1. one kind is used for the treatment of leukodermic pure Chinese medicine composition, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 35 parts of Fructus Psoraleaes, 30 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of common fig leaf juice.
2. a kind of preparation method that is used for the treatment of leukodermic pure Chinese medicine composition according to claim 1, it may further comprise the steps:
1) by following weight ratio weighting raw materials: 35 parts of Fructus Psoraleaes, 30 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of common fig leaf juice;
2) raw material of above-mentioned weight portion is added 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that the filtrate temperature is concentrated into relative density at 45-50 ℃;
3) ethanol is added above-mentioned clear paste and makes and contain alcohol amount and reach 60%, temperature 45-50 ℃ static, precipitate 48 hours, filtration, Recycled ethanol;
4) add that to account for gross weight be 0.5% active carbon, heat filtration 30 minutes;
5) add that to account for gross weight be 1% stevioside, taste masking;
6) adding distil water filters to total amount, packing, and sterilization gets final product.
CN2012104814527A 2012-11-23 2012-11-23 Pure traditional Chinese medicinal composition for treating leucoderma and preparation method thereof Pending CN102949457A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101112434A (en) * 2007-07-31 2008-01-30 刘锐军 Leukoderma treating medicine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101112434A (en) * 2007-07-31 2008-01-30 刘锐军 Leukoderma treating medicine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《中国医学百科全书》编辑委员会: "《维吾尔医学》", 30 September 2005, 上海科学技术出版社 *
杨梅玉: "中医药治疗白癜风的现状", 《北京中医药大学学报(中医临床版)》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo

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