KR20080005378A - 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도 - Google Patents

인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도 Download PDF

Info

Publication number
KR20080005378A
KR20080005378A KR1020077024874A KR20077024874A KR20080005378A KR 20080005378 A KR20080005378 A KR 20080005378A KR 1020077024874 A KR1020077024874 A KR 1020077024874A KR 20077024874 A KR20077024874 A KR 20077024874A KR 20080005378 A KR20080005378 A KR 20080005378A
Authority
KR
South Korea
Prior art keywords
glp
seq
mimetic
deletion
polypeptide
Prior art date
Application number
KR1020077024874A
Other languages
English (en)
Korean (ko)
Inventor
카린 티. 오'네일
크리스텐 피차
Original Assignee
센토코 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 센토코 인코포레이티드 filed Critical 센토코 인코포레이티드
Publication of KR20080005378A publication Critical patent/KR20080005378A/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077024874A 2005-03-28 2005-12-22 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도 KR20080005378A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USPCT/US2005/097175 2005-03-28
US2005097175 2005-03-28

Publications (1)

Publication Number Publication Date
KR20080005378A true KR20080005378A (ko) 2008-01-11

Family

ID=38256744

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077024874A KR20080005378A (ko) 2005-03-28 2005-12-22 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도

Country Status (12)

Country Link
EP (1) EP1871811A4 (es)
JP (1) JP2008546373A (es)
KR (1) KR20080005378A (es)
CN (1) CN101389346A (es)
AU (1) AU2005339797A1 (es)
BR (1) BRPI0520168A2 (es)
CA (1) CA2603359A1 (es)
CR (1) CR9481A (es)
IL (1) IL186307A0 (es)
MX (1) MX2007011975A (es)
NO (1) NO20075272L (es)
WO (1) WO2007081302A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200843794A (en) 2006-12-21 2008-11-16 Centocor Inc Use of long-acting GLP-1 receptor agonists to improve insulin sensitivity and lipid profiles
CN111574583B (zh) * 2020-04-10 2021-06-25 上海海路生物技术有限公司 蛋白复性试剂及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3224700A (en) * 1999-02-08 2000-08-25 Chiron Corporation Fibroblast growth factor receptor-immunoglobulin fusion
US7271149B2 (en) * 2000-12-07 2007-09-18 Eli Lilly And Company GLP-1 fusion proteins
EP1545608A4 (en) * 2002-06-28 2006-09-13 Centocor Inc CH1-DELETED MAMMED MUICETIC BODIES, COMPOSITIONS, METHODS AND APPLICATIONS
AU2003256336A1 (en) * 2002-06-28 2004-01-19 Centocor, Inc. Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
WO2005005604A2 (en) * 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
EP1750754A4 (en) * 2004-03-31 2010-09-22 Centocor Ortho Biotech Inc HUMAN GLP-1 MIMETIC BODIES, COMPOSITIONS, METHODS AND USES

Also Published As

Publication number Publication date
MX2007011975A (es) 2008-03-14
CR9481A (es) 2009-01-14
WO2007081302A3 (en) 2008-11-13
IL186307A0 (en) 2008-01-20
CA2603359A1 (en) 2007-07-19
JP2008546373A (ja) 2008-12-25
EP1871811A2 (en) 2008-01-02
WO2007081302A2 (en) 2007-07-19
AU2005339797A1 (en) 2007-07-19
NO20075272L (no) 2007-12-28
CN101389346A (zh) 2009-03-18
EP1871811A4 (en) 2009-07-22
BRPI0520168A2 (pt) 2009-04-22

Similar Documents

Publication Publication Date Title
KR20090039787A (ko) 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도
WO2005097175A2 (en) Human glp-1 mimetibodies, compositions, methods and uses
US20070128193A1 (en) GLP-1 agonists, compositions, methods and uses
KR20090092336A (ko) 인슐린 감수성 및 지질 프로필을 개선하기 위한 장기 작용 ｇｌｐ-1 수용체 작용제의 용도
KR20060117930A (ko) 인간 ｅｐｏ 미메틱 힌지 코어 미메티바디, 조성물, 방법및 용도
MXPA05000202A (es) Cuerpos mimeicos ch1-deletados de epo de mimetica de mamifero.
KR20080005378A (ko) 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid