KR20080004581A - 불안 관련 장애의 치료 방법 - Google Patents
불안 관련 장애의 치료 방법 Download PDFInfo
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- KR20080004581A KR20080004581A KR1020077025774A KR20077025774A KR20080004581A KR 20080004581 A KR20080004581 A KR 20080004581A KR 1020077025774 A KR1020077025774 A KR 1020077025774A KR 20077025774 A KR20077025774 A KR 20077025774A KR 20080004581 A KR20080004581 A KR 20080004581A
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- treatment
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- gaba
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- anxiety
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| CA2862076C (en) | 2012-01-23 | 2020-04-21 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
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| US6632447B1 (en) * | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| AU4100699A (en) | 1998-05-28 | 1999-12-13 | Sepracor, Inc. | Compositions and methods employing r(-) fluoxetine and other active ingredients |
| CA2381895A1 (en) * | 1999-08-27 | 2001-03-08 | Merck & Co., Inc. | Method for treating or preventing chronic prostatitis or chronic pelvic pain syndrome |
| US20020173495A1 (en) * | 2000-08-24 | 2002-11-21 | Dalton James T. | Selective androgen receptor modulators and methods of use thereof |
| EP1374952B1 (en) * | 2001-01-17 | 2006-09-06 | Hythiam, Inc. | Use of flumazenil in developing a drug for the treatment of alcohol dependence |
| RU2322985C2 (ru) * | 2001-02-15 | 2008-04-27 | Хитиям, Инк. | Применение флумазенила в производстве лекарственного средства для лечения кокаиновой зависимости |
| GB0311859D0 (en) * | 2003-05-22 | 2003-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| EP2343073A3 (en) * | 2003-12-11 | 2011-10-12 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| AU2006235318A1 (en) * | 2005-04-07 | 2006-10-19 | Hythiam, Inc. | Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence |
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2006
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- 2006-04-06 JP JP2008505625A patent/JP2008538748A/ja not_active Withdrawn
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- 2006-04-07 CA CA002603533A patent/CA2603533A1/en not_active Abandoned
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2007
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