CA2604887A1 - Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence - Google Patents

Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence Download PDF

Info

Publication number
CA2604887A1
CA2604887A1 CA002604887A CA2604887A CA2604887A1 CA 2604887 A1 CA2604887 A1 CA 2604887A1 CA 002604887 A CA002604887 A CA 002604887A CA 2604887 A CA2604887 A CA 2604887A CA 2604887 A1 CA2604887 A1 CA 2604887A1
Authority
CA
Canada
Prior art keywords
finasteride
composition
inhibitor
gabaa
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002604887A
Other languages
English (en)
French (fr)
Inventor
Sanjay Sabnani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catasys Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2604887A1 publication Critical patent/CA2604887A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
CA002604887A 2005-04-07 2006-04-06 Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence Abandoned CA2604887A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66903305P 2005-04-07 2005-04-07
US60/669,033 2005-04-07
US72897905P 2005-10-21 2005-10-21
US72901305P 2005-10-21 2005-10-21
US60/729,013 2005-10-21
US60/728,979 2005-10-21
PCT/US2006/013296 WO2006110642A2 (en) 2005-04-07 2006-04-06 Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence

Publications (1)

Publication Number Publication Date
CA2604887A1 true CA2604887A1 (en) 2006-10-19

Family

ID=37087555

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002604887A Abandoned CA2604887A1 (en) 2005-04-07 2006-04-06 Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence
CA002603533A Abandoned CA2603533A1 (en) 2005-04-07 2006-04-07 Methods for treating anxiety related disorders
CA002603519A Abandoned CA2603519A1 (en) 2005-04-07 2006-04-07 Methods for the treatment of substance abuse and dependence

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002603533A Abandoned CA2603533A1 (en) 2005-04-07 2006-04-07 Methods for treating anxiety related disorders
CA002603519A Abandoned CA2603519A1 (en) 2005-04-07 2006-04-07 Methods for the treatment of substance abuse and dependence

Country Status (12)

Country Link
US (3) US20080207601A1 (enExample)
EP (3) EP1868593A2 (enExample)
JP (3) JP2008538748A (enExample)
KR (2) KR20080004581A (enExample)
AU (3) AU2006235318A1 (enExample)
BR (2) BRPI0609744A2 (enExample)
CA (3) CA2604887A1 (enExample)
CR (2) CR9410A (enExample)
IL (2) IL186450A0 (enExample)
MX (2) MX2007012355A (enExample)
NO (2) NO20075155L (enExample)
WO (3) WO2006110642A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050192271A1 (en) 2003-07-15 2005-09-01 Hythiam, Inc. Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse
AU2006235318A1 (en) * 2005-04-07 2006-10-19 Hythiam, Inc. Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence
US20090269795A1 (en) * 2007-03-09 2009-10-29 The Research Foundation Of State University Of New York Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability
US8586634B2 (en) * 2007-06-15 2013-11-19 University Of Florida Research Foundation, Inc. Therapeutic compounds
CA2707980C (en) 2007-12-17 2015-05-12 Labopharm Inc. Misuse preventative, controlled release formulation
ITRM20080436A1 (it) * 2008-08-06 2010-02-07 Francesco Marrosu Uso della finasteride e di altre sostanze inibenti l'enzima 5-a-reduttasi per la prevenzione e la cura dei disturbi dell'impulso e dell'aggressivita'
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
CA2746888C (en) 2008-12-16 2015-05-12 Labopharm (Barbados) Limited Misuse preventative, controlled release formulation
WO2010094074A1 (en) * 2009-02-20 2010-08-26 Palmaya Pty Ltd Pharmaceutical preparation and delivery system
WO2011073985A1 (en) * 2009-12-14 2011-06-23 Coeruleus Ltd. Compositions and methods of counteracting residual sedative effects of sleep/ hypnotic drugs
CA2785056A1 (en) 2009-12-22 2011-07-21 Pondera Biotechnologies, LLC Methods and compositions for treating distress dysfunction and enhancing safety and efficacy of specific medications
WO2012006683A1 (en) * 2010-07-16 2012-01-19 Controlled Release Technologies Pty Ltd Pharmaceutical compositions for sustained delivery of benzodiazepine antagonists
US8968722B2 (en) * 2010-12-29 2015-03-03 Mead Johnson Nutrition Company Milk-based nutritional compositions containing lactoferrin and uses thereof
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
CA2862076C (en) 2012-01-23 2020-04-21 Sage Therapeutics, Inc. Neuroactive steroid formulations and methods of treating cns disorders
PL2887944T3 (pl) * 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego
JP2016501876A (ja) 2012-11-30 2016-01-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ステロイドの抗痙攣活性
SG10201706063UA (en) * 2012-12-18 2017-09-28 Univ Washington Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP3160969B1 (en) * 2014-06-26 2023-09-13 The Johns Hopkins University Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
CN113616661A (zh) 2016-03-08 2021-11-09 萨奇治疗股份有限公司 神经活性类固醇、其组合物及用途
US20180050005A1 (en) * 2016-08-16 2018-02-22 Janssen Pharmaceutica Nv Concentrated Solution of 17-Hydroxydocosahexaenoic Acid
WO2018127601A1 (en) * 2017-01-09 2018-07-12 Asarina Pharma Ab Injectable suspensions
CN111050801B (zh) * 2017-03-28 2023-03-28 Ldn制药有限公司 用于治疗癌症的增加bcl2-相关的细胞死亡激动剂表达的药剂
GB201704909D0 (en) 2017-03-28 2017-05-10 Ldn Pharma Ltd Cancer therapy
KR101898814B1 (ko) 2017-09-07 2018-09-13 백창목 도어 개폐용 도어록
WO2019055939A1 (en) * 2017-09-18 2019-03-21 SEN-JAM Pharmaceutical LLC METHODS AND COMPOSITIONS FOR INHIBITING SYMPTOMS ASSOCIATED WITH OPIOID WEANING
US11129803B2 (en) 2017-09-18 2021-09-28 SEN-JAM Pharmaceutical LLC Methods and compositions to inhibit tolerance to opioids
US12414956B2 (en) 2017-09-20 2025-09-16 Calista Capital, Llc Method for smoking cessation
WO2019060171A1 (en) * 2017-09-20 2019-03-28 Calista Capital, Llc METHOD FOR STOPPING TOBACCO
EP3482751A1 (en) * 2017-11-14 2019-05-15 LDN Pharma Limited Cancer treatment
KR20200140832A (ko) * 2018-04-05 2020-12-16 아사리나 파마 에이피에스 물질 금단 장애를 치료하기 위한 gaba-a 길항제
CA3095682A1 (en) * 2018-04-06 2019-10-10 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of substance use disorders
WO2020061410A1 (en) 2018-09-20 2020-03-26 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering
WO2020181340A1 (en) * 2019-03-14 2020-09-17 Palmaya Pty Ltd Treatment of inflammatory diseases of the central nervous system
HUE064596T2 (hu) 2019-08-26 2024-03-28 Period Pill Bv Menstruációs ciklus által kiváltott tünetek kezelése
US12233070B2 (en) 2020-06-30 2025-02-25 University Of Mississippi Medical Center Methods for treating benzodiazepine misuse/use disorder
CA3201498A1 (en) * 2020-11-27 2022-06-02 Trexapharm Pty Ltd Compositions comprising flumazenil and naltrexone and methods for use thereof
US20220265601A1 (en) * 2021-02-10 2022-08-25 David Alan Heldreth, JR. Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses.
US12396981B2 (en) 2023-03-09 2025-08-26 William Shulman Methods of using DMT

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034087A (en) * 1973-12-17 1977-07-05 The Regents Of The University Of Michigan Pharmaceutical composition and process of treatment
US4595684A (en) * 1985-08-16 1986-06-17 Ciba-Geigy Corporation Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof
US5175155A (en) * 1991-10-07 1992-12-29 Sterling Winthrop Inc. Win 49596-finasteride method of use and compositions
DE4344462C2 (de) * 1993-12-22 1996-02-01 Schering Ag Zusammensetzung für die Empfängnisverhütung
FR2719843B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique.
US5521181A (en) * 1995-01-27 1996-05-28 Abbott Laboratories Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists
IT1274481B (it) * 1995-05-12 1997-07-17 Indena Spa Composizioni farmaceutiche per il trattamento della alcol-dipendenza
AU751496B2 (en) * 1997-08-28 2002-08-15 Vela Pharmaceuticals Inc. Androgen activity antagonists as therapies for anorexia, anorexia nervosa, and disorders characterized by a pathologically underweight condition
US6632447B1 (en) * 1998-05-07 2003-10-14 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
AU4100699A (en) 1998-05-28 1999-12-13 Sepracor, Inc. Compositions and methods employing r(-) fluoxetine and other active ingredients
CA2381895A1 (en) * 1999-08-27 2001-03-08 Merck & Co., Inc. Method for treating or preventing chronic prostatitis or chronic pelvic pain syndrome
US20020173495A1 (en) * 2000-08-24 2002-11-21 Dalton James T. Selective androgen receptor modulators and methods of use thereof
EP1374952B1 (en) * 2001-01-17 2006-09-06 Hythiam, Inc. Use of flumazenil in developing a drug for the treatment of alcohol dependence
RU2322985C2 (ru) * 2001-02-15 2008-04-27 Хитиям, Инк. Применение флумазенила в производстве лекарственного средства для лечения кокаиновой зависимости
GB0311859D0 (en) * 2003-05-22 2003-06-25 Merck Sharp & Dohme Therapeutic agents
EP2343073A3 (en) * 2003-12-11 2011-10-12 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
AU2006235318A1 (en) * 2005-04-07 2006-10-19 Hythiam, Inc. Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence

Also Published As

Publication number Publication date
KR20080004580A (ko) 2008-01-09
AU2006235234A1 (en) 2006-10-19
EP1901727A4 (en) 2009-11-11
AU2006235257A1 (en) 2006-10-19
BRPI0609744A2 (pt) 2010-04-27
MX2007012353A (es) 2008-01-16
JP2008538748A (ja) 2008-11-06
CA2603533A1 (en) 2006-10-19
CA2603519A1 (en) 2006-10-19
WO2006110580A3 (en) 2007-08-16
EP1868593A2 (en) 2007-12-26
NO20075155L (no) 2008-01-07
CR9410A (es) 2008-02-21
EP1868432A4 (en) 2009-11-04
WO2006110642A2 (en) 2006-10-19
IL186447A0 (en) 2008-08-07
AU2006235257B2 (en) 2010-11-04
WO2006110642A3 (en) 2009-04-23
JP2008535852A (ja) 2008-09-04
NO20075161L (no) 2008-01-07
KR20080004581A (ko) 2008-01-09
EP1901727A2 (en) 2008-03-26
AU2006235318A1 (en) 2006-10-19
JP2008535850A (ja) 2008-09-04
IL186450A0 (en) 2008-01-20
WO2006110557A3 (en) 2009-04-16
US20080280885A1 (en) 2008-11-13
WO2006110580A2 (en) 2006-10-19
WO2006110557A2 (en) 2006-10-19
MX2007012355A (es) 2008-01-16
CR9413A (es) 2008-01-21
US20080207601A1 (en) 2008-08-28
EP1868432A2 (en) 2007-12-26
US8012958B2 (en) 2011-09-06
BRPI0610693A2 (pt) 2016-11-22
US20080255097A1 (en) 2008-10-16

Similar Documents

Publication Publication Date Title
CA2604887A1 (en) Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence
US20250302771A1 (en) Treatment of opioid use disorder, opioid withdrawal symptoms and chronic pain
AU2020267217A1 (en) Therapeutic methods employing noribogaine and related compounds
US10300068B2 (en) Method of treating insomnia
US20160213680A1 (en) Compositions and methods using flumazenil with opioid analgesics for treating pain and/or addiction, and with diversion and/or overdose mitigation
CN101272683A (zh) 治疗与焦虑有关疾病的方法
US8791093B2 (en) Pharmaceutical delivery systems for treatment of substance abuse and other addictions
CA3068036A1 (en) Use to buprenorphine in combination with an opioid to treat pain
TW202327616A (zh) 治療物質使用症(substance use disorder)之方法
WO2024261775A1 (en) A drug-antagonist combination dosage form
CN114469927A (zh) 一种用于防治多囊卵巢综合征的药物组合物及其用途
WO2008051760A2 (en) Combination therapy for the treatment of pain
Steiger Sleep and Its Modulation by Substances That Affect GABAA Receptor Function Axel Steiger
US20090281194A1 (en) Combinations for treating HIV-associated pain
US20080108622A1 (en) Combination therapy for the treatment of pain

Legal Events

Date Code Title Description
FZDE Discontinued