KR20070121333A - Composition for treating or preventing a atopy epidermal inflammation - Google Patents

Abstract

A composition comprising the extracts of balsam leaves and petals is provided to prevent or treat atopic dermatitis without side effects such as hair growth, skin shrinking, and lowering of skin pigments and skin thickness in the applied region by using natural products. A composition for preventing or treating atopic dermatitis comprises 0.05-99.99 wt.% of the extracts of balsam leaves and petals which are prepared by extracting with distilled water, methanol, ethanol, acetone, ethylacetate, saturated normal butanol, chloroform, methylene chloride or a mixture thereof. The composition is used for a cosmetic, pharmaceutical, food or soap composition, wherein the cosmetic composition is formulated as emulsion, lotion, cream, solution, suspension, anhydrous product(oil and glycol), gel, mask, pack or powder.

Description

Composition for Treating or Preventing a Atopy Epidermal Inflammation

The present invention relates to a therapeutic or prophylactic composition for atopic dermatitis.

Atopy is derived from the Latin word atopia, which means 'weird'. Atopic dermatitis is a disease characterized by severe itching and chronic skin rashes, the most common form of infantile eczema.

The cause of atopic dermatitis is not yet clearly identified, but a person with atopic dermatitis usually has an allergic reaction to foreign objects such as house dust, mites, animal hair, food, pollen or mold. In addition, it is estimated that atopic dermatitis is caused by disturbance of immune system in that it is accompanied by allergic rhinitis, asthma, conjunctivitis, enteritis.

Atopic dermatitis usually begins with infantile eczema, commonly referred to as febrile fever, with itching in the acute phase, reddening, swelling, or millet-like growth, small blisters, moist scabs, and itching in the chronic phase. The skin may become hard, thick, thin, or may have scales such as rice powder sitting, blacking, or whitening.

Among the currently used therapeutic drugs, steroid-based drugs have excellent anti-inflammatory and immunosuppressive effects, but when used for a long time, they cause side effects such as hairs on the skin of the right area, atrophy of the skin, less skin pigment, and thinner skin.

Recently, in order to minimize side effects of existing chemicals, efforts to find natural extracts effective for atopic dermatitis have been continued. For example, in order to improve atopic dermatitis, a combination extract of red ginseng, baekbaek, gimo and lobular vegetation is started. Korean Patent No. 0513659, Korean Patent No. 0584039, which discloses vine tea extract, and Korean Patent No. 0511494, which discloses sewage extract.

The present invention also discloses a therapeutic effect of atopic dermatitis using a natural extract.

An object of the present invention to provide a composition for the treatment or prevention of atopic dermatitis.

Specific embodiments of the present invention and the like will be presented below.

The present invention relates to a therapeutic or prophylactic composition for atopic dermatitis, wherein the therapeutic or prophylactic composition for atopic dermatitis comprises a balsam leaf extract and / or balsam petal extract.

The present inventors extract balsam leaves or petals with methanol, distilled water, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform or methylene chloride, and include the extract in a conventional cosmetic product to patients suffering from atopic dermatitis. As a result, the effect of remarkably improving atopic dermatitis was confirmed.

Therefore, what is included as an active ingredient in the composition for the treatment or prevention of atopic dermatitis of the present invention is Balsam leaf extract and / or Balsam petal extract.

Here, the balsam leaf extract or the balsam petal extract includes those obtained by extracting balsam leaves or petals with methanol, distilled water, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform, methylene chloride, or a mixed solvent thereof. Or extracts in the form of essences obtained by compressing petals. In addition, although the following examples and experimental examples were made with balsam leaves and balsam petals, those skilled in the art will be able to easily verify within the range of their ordinary abilities whether balsam stems or roots have the same effect within the range of balsam stems or roots. It is understood that extracted with an extraction solvent or extracted in the form of a essence, as long as it has a therapeutic or prophylactic effect of atopic dermatitis.

On the other hand, in the present specification, balsam refers to the annual herb of the dicotyledonous plant Apan group Agaricaceae, Balsamaceae, as long as it is included in this plant classification, it is understood that the specific kind is not. Therefore, for example, Impatiens aphanantha HOOKER), San mulbongseon (Impatiens furcillata HEMSLEY), hair mulbongseon (Impatiens hypophylla var koreana MAKAI) yellow mulbongseon (Impatiens noli -. Langere L.) , Cream mulbongseon (Impatiens noli - tangere for. pallida HERMANN), mulbongseon (Impatiens textori It is understood that MIQ), Impatiens textori for Atrosanguinea (NAK) T. LEE, Impatiens textori for Pallescens (HONDA) HARA, and the like can all be used in the present invention.

The composition for treating or preventing atopic dermatitis of the present invention includes the balsam leaf extract or the balsam petal extract, and the previously exemplified previously known to be effective in atopic dermatitis so as to increase or enhance the atopic dermatitis treatment or prevention effect. Compounds or plant extracts, which may include compounds of the bar or plant extracts, and may also contain other known compounds or plant extracts known to be effective for atopic dermatitis, and furthermore, compounds or plant extracts that have an effect on atopic dermatitis, which will be revealed in the future. It may include.

Here, the other compounds or plant extracts include, but are not limited to, the aforementioned steroidal compounds, red ginseng, platinum, chylo and lobular vegetation mixed extracts, vine tea extracts, sewage extracts, and the like.

The compound or plant extract as exemplified above may be included in the composition for the treatment or prevention of atopic dermatitis of the present invention together with balsam leaf extract or balsam petal extract.

On the other hand, in the composition for treating or preventing atopic dermatitis of the present invention, Balsam leaf extract or Balsam petal extract may be included in any amount within the range that does not have toxicity to the human body depending on the severity of atopic dermatitis, Specifically, the composition may be included in an amount of 0.05 wt% to 99.99 wt% with respect to the total weight of the composition.

On the other hand, as can be seen in the following experimental example, Balsam leaf extract and Balsam petal extract when used in atopic dermatitis at the same time, the effect of improving atopic dermatitis is improved, the atopic dermatitis treatment or prevention of the present invention Preferably, the composition includes Balsam leaf extract and Balsam petal extract.

In a specific embodiment, the composition for treating or preventing atopic dermatitis of the present invention can be understood as a cosmetic composition.

When the composition for treating or preventing atopic dermatitis of the present invention is identified as a cosmetic composition, the cosmetic composition may be prepared in various forms, for example, emulsion, lotion, cream (oil-in-water, water-in-oil, multiphase). , Solutions, suspensions (anhydrous and aqueous), anhydrous products (oil and glycols), gels, masks, packs or powders and the like.

The cosmetic composition for treating or preventing atopic dermatitis of the present invention may include an acceptable carrier in cosmetic preparations in addition to balsam leaf extract and / or balsam petal extract.

Herein, "acceptable carriers in cosmetic preparations" are compounds or compositions already known and used that may be included in cosmetic preparations, or compounds or compositions which will be developed in the future, which have no toxicity, instability or irritation more than the body can adapt to in contact with the skin. Say that.

The carrier is included in the cosmetic composition for treating or preventing atopic dermatitis of the present invention from about 1% by weight to about 99.99% by weight, preferably from about 50% to about 99% by weight of the composition. Can be.

However, since the ratio varies depending on the form of the above-described preparation of the cosmetic of the present invention and its specific application site (face, hand, etc.), its preferred application amount, etc., the ratio is in any aspect to the present invention. It should not be understood as limiting the scope of.

Meanwhile, examples of the carrier include alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, moisturizers, viscosity modifiers, emulsions, stabilizers, sunscreen agents, colorants, fragrances, and the like.

Alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, humectants, viscosity modifiers, emulsions, stabilizers, sunscreens, colorants, compounds / compositions that can be used as fragrances, etc., which can be used as the carrier are already known in the art. As a result, those skilled in the art can select and use appropriate materials / compositions.

In another specific embodiment, the composition for treating or preventing atopic dermatitis of the present invention can be understood as a pharmaceutical composition.

The pharmaceutical compositions of the present invention may be administered via a variety of routes including oral, transdermal, subcutaneous, intravenous or intramuscular during clinical administration. In addition, the pharmaceutical composition of the present invention may be formulated in various formulations, and when formulated, it may be formulated using conventional diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants. . Solid preparations for oral administration include tablets, pills, powders, granules, and capsules, and the like, which may be prepared from at least one excipient such as starch, calcium carbonate, sucrose, lactose and It is prepared by mixing gelatin. Lubricants may also be used in addition to simple excipients. Liquid preparations for oral administration include suspensions, solvents, emulsions, and syrups.In addition to the commonly used simple diluents, water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives, etc. May be included. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized formulations and suppositories. As the non-aqueous solvent and the suspension solvent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used. As the base of the suppository, Whitepsol, macrogol, tween 61, cacao butter, laurin butter, glycerol, gelatin and the like can be used.

The pharmaceutical composition of the present invention usually has a daily dosage in the range of 0.1 to 150 mg / kg body weight, and can be administered once or in divided doses. However, since the actual dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as the route of administration, the age, sex, weight of the patient, and the severity of the patient, the dosage is in any aspect the scope of the present invention. It should not be understood as limiting.

In another specific embodiment, the composition for treating or preventing atopic dermatitis of the present invention can be understood as a food composition.

The composition for treating or preventing atopic dermatitis of the present invention may be prepared from gums, vitamin complexes, health supplements, special nutritional supplements, functional drinks, and the like.

On the other hand, it is to be understood that the food composition of the present invention also includes a case made in the form of a tea (tea) composition such as tea bags (though the tea composition is included in the form of heated and shredded Balsam leaves or Balsam petals. No, because it is in the form of an extract when used).

In addition to the balsam leaf extract or the balsam petal extract, the food composition of the present invention may be added with glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, or polysaccharides such as dextrin, cyclodextrin, and xylitol. Sugar alcohols such as sorbitol, erythritol and the like may also be added, and sweeteners such as taurine and stevia extract may also be added, and other food additives may be added.

In another specific embodiment, the composition for treating or preventing atopic dermatitis of the present invention can be understood as a soap composition.

When the composition for treating or preventing atopic dermatitis of the present invention is identified as a soap composition, the soap composition of the present invention may be prepared by including balsam leaf extract or balsam petal extract on a soap base, and as an additive, a skin moisturizer and an emulsifier It may be prepared, including a water softener.

As the soap base material, vegetable oils such as palm oil, palm oil, soybean oil, perm oil, olive oil, palm kernels, or animal oils such as tallow, pork, sunny and fish oils can be used, and the skin moisturizing agent is glycerin, erythritol and polyethylene glycol. , Propylene glycol, butylene glycol, pentylene glycol, hexyl glycol, isopropyl myristate, silicone derivatives, aloe vera, sorbitol and the like can be used, the emulsifiers include natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc. May be used, and tetrasodium idieti may be used as the water softener.

The soap composition of the present invention may further include an antimicrobial agent, a dispersant, a foam inhibitor, a solvent, a scale inhibitor, a corrosion inhibitor, a perfume, a pigment, a metal ion blocking agent, an antioxidant, a preservative, and the like as an additive.

In the soap composition of the present invention, the soap base or additives may be included in an amount generally used in the art, and the soap base is generally 99.9 to 50 wt% based on the total content of the soap composition. It may be added, the additive may be added in 1% to 20% by weight.

Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited thereto.

< Example > Preparation of Balsam Leaf Extract and Balsam Petal Extract

Example 1 Preparation Example 1 of Balsam Leaf Extract

200 g of the pulverized pulverized leaf was extracted with reflux for about 5 hours with about 2 L of 80% methanol. The resultant was filtered using Whatman No. 2 filter paper at room temperature to remove insoluble matters, and then concentrated under reduced pressure in vacuo and then lyophilized to prepare a target balsam leaf extract.

Example 2 Preparation Example 2 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but distilled water was used as an extraction solvent instead of 80% of methanol.

Example 3 Preparation Example 3 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but 90% ethanol was used instead of 80% methanol.

Example 4 Preparation Example 4 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but 70% acetone was used instead of 80% methanol.

<Example 5> Preparation of balsam leaf extract Example 5

Balsam leaf extract was prepared in the same manner as in <Example 1>, but extraction solvent was used as ethyl acetate instead of 80% methanol.

<Example 6> Preparation Example 6 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but instead of 80% methanol, saturated normal butanol was used.

<Example 7> Preparation of balsam leaf extract Example 7

Balsam leaf extract was prepared in the same manner as in <Example 1>, but extraction solvent was used chloroform instead of 80% methanol.

<Example 8> Preparation Example 8 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but methylene chloride was used instead of 80% methanol.

Example 9 Preparation Example 9 of Balsam Leaf Extract

Balsam leaf extract was prepared in the same manner as in <Example 1>, but the extraction solvent was used instead of 80% methanol.

<Example 10> Preparation of balsam petal extract Example 1

Balsam petal extract was prepared in the same manner as in <Example 1>.

Example 11 Preparation Example 2 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 2>.

Example 12 Preparation Example 3 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 3>.

Example 13 Preparation Example 4 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 4>.

Example 14 Preparation 5 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 5>.

Example 15 Preparation 6 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 6>.

Example 16 Preparation 7 of Balsam Petal Extract

Balsam petal extract was prepared in the same manner as in <Example 7>.

<Example 17> Preparation of balsam petal extract Example 8

Balsam petal extract was prepared in the same manner as in <Example 8>.

<Example 18> Preparation of balsam petal extract Example 9

Balsam petal extract was prepared in the same manner as in <Example 9>.

Experimental Example: Sensory Evaluation of Atopic Dermatitis

Experimental Example 1 Sensory Evaluation for the Treatment of Atopic Dermatitis 1

First, 5.0% by weight of the extract of each embodiment, beeswax 2.0% by weight, cyclomethicone 2.0% by weight, liquid paraffin 5.0% by weight, squalane 5.0% by weight, stearic acid 2.0% by weight, lipophilic monostearic acid glycerin 3.0% by weight, macade Mia oil 4.0 wt%, glycerin 4.0 wt%, propylene glycol 3.0 wt%, butylene glycol 3.0 wt%, triethanolamine 1.0 wt%, aluminum magnesium silicate 0.5 wt%, pigment 12.0 wt%, preservative trace, trace amount of purified water To prepare a cosmetic composition containing the extract of each example.

The cosmetic composition, 5 to 30 years old atopic dermatitis patients with atopic dermatitis for at least two years to be applied to the skin once every 30 days after cleaning every evening to measure the degree of atopic dermatitis treatment. Thirty subjects in the first group were scored according to the four-point scale (4: very good, 3: moderately good, 2: slightly better, 1: no change, 0: worse). The average value is shown in Table 6 below.

Thirty days after the onset of atopic dermatitis, the overall improvement of the symptoms of atopic dermatitis was divided into five stages.

Here, the cosmetic composition of the comparative example is a cosmetic composition (ie beeswax 2.0% by weight, cyclomethicone 2.0% by weight, liquid paraffin 5.0% by weight, squalane 5.0% by weight, stearic acid 2.0% by weight, Chin) 3.0% by weight of glycerin monostearate, 4.0% by weight of macadamia oil, 4.0% by weight of glycerin, 3.0% by weight of propylene glycol, 3.0% by weight of butylene glycol, 1.0% by weight of triethanolamine, 0.5% by weight of aluminum magnesium silicate, 12.0% by weight of pigment %, A preservative trace amount, a fragrance trace amount, and a composition prepared with a residual amount of purified water).

division Sensory evaluation result Cosmetic Composition of <Example 1> 3.48 <Example 2> 3.02 <Example 3> 3.26 <Example 4> 3.17 Example 5 2.69 <Example 6> 2.97 <Example 7> 3.01 <Example 8> 3.37 Example 9 2.77 <Example 10> 3.36 <Example 11> 3.47 <Example 12> 3.21 Example 13 3.26 <Example 14> 3.29 <Example 15> 3.21 <Example 16> 3.09 <Example 17> 3.08 Example 18 3.09 Example 19 2.96 Comparative Example 1.43

Table 1 shows that Balsam leaf extract and petal extract of the present invention has a therapeutic effect against atopic dermatitis.

Experimental Example 2 Sensory Evaluation 2 for Treatment of Atopic Dermatitis

In this experiment, we evaluated whether the mixture of Balsam leaf extract and Balsam petal extract were effective for higher atopic dermatitis.

The cosmetic composition to be used in this experiment was prepared in the same manner as in <Experimental Example 1>, but without using the 5.0% by weight of the extract of one embodiment, 2.5% by weight of the extract of <Example 1> and the extract of <Example 10> 2.5% by weight, 2.5% by weight of the extract of <Example 2> and 2.5% by weight of the extract of <Example 11>, 2.5% by weight of the extract of <Example 3> and 2.5% by weight of the extract of <Example 12>, <Example 2.5 wt% of the extract of Example 4 and 2.5 wt% of the extract of <Example 13>, 2.5 wt% of the extract of <Example 5> and 2.5 wt% of the extract of <Example 14>, 2.5 of the extract of <Example 6> % By weight and 2.5% by weight of the extract of <Example 15>, 2.5% by weight of the extract of <Example 7> and 2.5% by weight of the extract of <Example 16>, 2.5% by weight of the extract of <Example 8> and <Example 17> of 2.5% by weight of the extract, or 2.5% by weight of the extract of <Example 9> and 2.5% by weight of the extract of <Example 18> were used.

The experiment was performed in the same manner as in <Experimental Example 1>, the results are also shown in the following <Table 2> in the same manner.

division Sensory evaluation result Extract of <Example 1> + Cosmetic composition containing an extract of <Example 10> 3.87 Extract composition of <Example 2> + cosmetic composition containing an extract of <Example 11> 3.73 Extract of <Example 3> + Cosmetic composition containing an extract of <Example 12> 3.62 Extract composition of <Example 4> + cosmetic composition containing an extract of <Example 13> 3.84 Extract of <Example 5> + Cosmetic composition containing an extract of <Example 14> 3.64 Extract composition of <Example 6> + cosmetic composition containing the extract of <Example 15> 3.92 Extract composition of <Example 7> + cosmetic composition containing an extract of <Example 16> 3.52 Extract composition of <Example 8> + cosmetic composition containing an extract of <Example 17> 3.62 Extract of <Example 9> + Cosmetic composition containing an extract of <Example 18> 3.71

Table 2 shows that the treatment effect for atopic dermatitis is higher when the balsam leaf extract and the petal extract of the present invention are used alone.

As described above, according to the present invention can provide a composition for treating or preventing atopic dermatitis, including Balsam leaf extract and / or petal extract.

Claims (7)

A therapeutic or prophylactic composition for atopic dermatitis comprising at least one extract selected from the group consisting of Balsam leaf extract and Balsam petal extract. The method of claim 1, The Balsam leaf extract and Balsam petal extract are atopic dermatitis, characterized by extracting Balsam leaves and Balsam petals, respectively, methanol, distilled water, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform, methylene chloride, water or a mixed solvent thereof. Therapeutic or prophylactic composition for. The method of claim 1, The therapeutic or prophylactic composition for atopic dermatitis is a therapeutic or prophylactic composition for atopic dermatitis, characterized in that it comprises both Balsam leaf extract and Balsam petal extract. The method of claim 1, The composition is a composition for treating or preventing atopic dermatitis, characterized in that the cosmetic composition. The method of claim 1, The composition is a composition for the treatment or prevention of atopic dermatitis, characterized in that the pharmaceutical composition. The method of claim 1, The composition is a composition for the treatment or prevention of atopic dermatitis, characterized in that the food composition. The method of claim 1, The composition is a composition for the treatment or prevention of atopic dermatitis, characterized in that the soap composition.