KR20070106767A - 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 - Google Patents

바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 Download PDF

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Publication number
KR20070106767A
KR20070106767A KR1020077020680A KR20077020680A KR20070106767A KR 20070106767 A KR20070106767 A KR 20070106767A KR 1020077020680 A KR1020077020680 A KR 1020077020680A KR 20077020680 A KR20077020680 A KR 20077020680A KR 20070106767 A KR20070106767 A KR 20070106767A
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South Korea
Prior art keywords
methyl
ribofuranosyl
benzo
dihydro
group
Prior art date
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Withdrawn
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KR1020077020680A
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English (en)
Korean (ko)
Inventor
제쎄 디 케이처
크리스토퍼 돈 로버츠
세바스티안 요하네스 라인하르트 리에르
샤오링 쳉
마리야 프르하브크
비벡 쿠마르 라즈완시
로날드 콘래드 그리피스
김정우
Original Assignee
제네랩스 테크놀로지스, 인코포레이티드
길리애드 사이언시즈, 인코포레이티드
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Application filed by 제네랩스 테크놀로지스, 인코포레이티드, 길리애드 사이언시즈, 인코포레이티드 filed Critical 제네랩스 테크놀로지스, 인코포레이티드
Publication of KR20070106767A publication Critical patent/KR20070106767A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077020680A 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 Withdrawn KR20070106767A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
US60/657,463 2005-02-28

Publications (1)

Publication Number Publication Date
KR20070106767A true KR20070106767A (ko) 2007-11-05

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077021265A Withdrawn KR20070106781A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드프로드러그
KR1020077020680A Withdrawn KR20070106767A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020077021265A Withdrawn KR20070106781A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드프로드러그

Country Status (18)

Country Link
US (4) US7524825B2 (enExample)
EP (2) EP1853617A1 (enExample)
JP (2) JP2008531703A (enExample)
KR (2) KR20070106781A (enExample)
CN (2) CN101128474A (enExample)
AP (2) AP2007004118A0 (enExample)
AR (1) AR058419A1 (enExample)
AU (2) AU2006218704A1 (enExample)
BR (2) BRPI0607769A2 (enExample)
CA (2) CA2597685A1 (enExample)
EA (2) EA200701849A1 (enExample)
HR (2) HRP20070435A9 (enExample)
IL (2) IL184954A0 (enExample)
MX (2) MX2007010460A (enExample)
NO (2) NO20074613L (enExample)
TW (1) TW200640474A (enExample)
WO (2) WO2006093987A1 (enExample)
ZA (1) ZA200707410B (enExample)

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Also Published As

Publication number Publication date
US20090208457A1 (en) 2009-08-20
AU2006218704A1 (en) 2006-09-08
MX2007010463A (es) 2007-11-08
AP2007004128A0 (en) 2007-08-31
US20060252715A1 (en) 2006-11-09
TW200640474A (en) 2006-12-01
AR058419A1 (es) 2008-02-06
WO2006093987A1 (en) 2006-09-08
CN101142226A (zh) 2008-03-12
WO2006093986A1 (en) 2006-09-08
HRP20070435A9 (en) 2008-09-30
US20060194749A1 (en) 2006-08-31
JP2008531703A (ja) 2008-08-14
AP2007004118A0 (en) 2007-08-31
NO20074915L (no) 2007-11-20
CA2597685A1 (en) 2006-09-08
EP1853617A1 (en) 2007-11-14
ZA200707410B (en) 2008-10-29
EA200701850A1 (ru) 2008-02-28
IL184955A0 (en) 2007-12-03
US20090253648A1 (en) 2009-10-08
HRP20070436A2 (hr) 2008-02-29
US7534771B2 (en) 2009-05-19
BRPI0607769A2 (pt) 2009-10-06
CA2597683A1 (en) 2006-09-08
MX2007010460A (es) 2007-11-08
EP1853618A1 (en) 2007-11-14
HRP20070435A2 (hr) 2008-02-29
BRPI0607770A2 (pt) 2009-06-13
EA200701849A1 (ru) 2008-02-28
NO20074613L (no) 2007-11-27
CN101128474A (zh) 2008-02-20
KR20070106781A (ko) 2007-11-05
AU2006218705A1 (en) 2006-09-08
IL184954A0 (en) 2007-12-03
US7524825B2 (en) 2009-04-28
JP2008531704A (ja) 2008-08-14

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