KR20070102447A - 독성 유전자, 단백질, 및 그 용도 - Google Patents

독성 유전자, 단백질, 및 그 용도 Download PDF

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KR20070102447A
KR20070102447A KR1020070087191A KR20070087191A KR20070102447A KR 20070102447 A KR20070102447 A KR 20070102447A KR 1020070087191 A KR1020070087191 A KR 1020070087191A KR 20070087191 A KR20070087191 A KR 20070087191A KR 20070102447 A KR20070102447 A KR 20070102447A
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크리스토프 탕
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마이크로싸이언스 리미티드
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Abstract

나이제리아 메닌지티디스(Neisseria meningitidis)에서 유래된 일련의 유전자는 독성에 관련된 생성물을 코드화하는 것으로 나타난다. 그러므로, 이들 유전자의 동정은 감독된 미생물을 생산하는 것을 가능하게 한다. 더구나, 상기 유전자 또는 그들의 코드화된 생성물은 치료적 응용을 위한 백신의 제조에 사용될 수 있다.
나이제리아 메닌지티디스, 수막염, 독성 유전자, 이종성 항원, 펩티드

Description

독성 유전자, 단백질, 및 그 용도{VIRULENCE GENES, PROTEINS, AND THEIR USE}
본 발명은 독성 유전자, 단백질, 및 그 용도에 관한 것이다. 보다 구체적으로는, 본 발명은 나이제리아 메닌지티디스( Neisseria meningitidis )로부터 얻어진 유전자 및 단백질/펩티드에 관한 것이고, 치료 및 약 선별에서의 그들의 용도에 관한 것이다.
나이제리아 메닌지티디스는 패혈성 쇼크 및 세균성 수막염에 관련된 그램 (Gram) 음성적인 세균성 병원균이다. 이 세균은 선진국에서는 세균성 수막염의 주된 원인이고, 아프리카 및 중국에서 대규모의 유행병의 발생 원인이다. 영국에서는, 나이제리아 메닌지티디스는 교통 사고를 제외한, 어린이 사망의 주된 원인이다. 상기 세균은 자연적으로 사람의 비인강(卑咽腔)에 서식하면서 혈관에 접근하게 되어 심한 패혈증 또는 수막염을 야기한다. 현재의 항-미생물학이 신체로부터 세균을 제거하는 데에 효과적일지라도, 수막구균성 패혈증으로부터의 사망률은 아직 상당하다. 나이제리아 메닌지티디스에 의하여 야기되는 징후를 치료하거나 예방하기 위한 수단을, 예를 들어, 면역화에 의하여 제공하는 것이 바람직할 것이다.
본 발명은 나이제리아 메닌지티디스에서의 독성 유전자의 발견을 기반으로 하고 있다.
본 발명의 첫 번째 관점에 있어서, 본 발명의 펩티드는 치료상의 또는 진단상의 사용을 위해, 청구항 제 1항에 정의된 뉴클레오티드 서열 중 어느 하나, 또는 그램(Gram)-음성적인 세균 내의 이들의 동족체 또는 그의 기능성 단편을 포함하는 오페론에 의해 코드화된다.
상기 펩티드는 예방적 적용을 위한 백신에서의 사용을 포함하는, 나이제리아 감염의 치료를 위한 많은 치료학적인 사용을 포함할 수 있다.
두 번째 관점에 있어서, 상기에 정의된 펩티드를 코드화하는 폴리뉴클레오티드 또한 치료 또는 진단에 유용할 수 있다.
세 번째 관점에 있어서, 펩티드를 코드화하는 유전자는 감독(減毒)된 미생물의 제조에 사용할 수 있다. 감독된 미생물은 독성이 결핍된 균류를 제공하기 위해, 여기서 동정된 유전자의 하나 이상의 발현을 파괴하는 돌연변이를 갖는 것이 일반적이다. 이들 미생물은 또한 치료 및 진단에 사용될 수 있을 것이다.
네 번째 관점에 있어서, 본 발명에 따른 펩티드, 유전자 및 감독된 미생물은 나이제리아 또는 그램-음성 세균에 의한 감염과 연계된 질환의 치료 또는 예방에 사용될 수 있다.
발명의 상세한 설명
본 발명은 독성에 관계된 펩티드를 코드화하는 유전자의 발견에 기반을 두고 있다. 그러므로 본 발명의 펩티드 및 유전자는 감염을 치료하기 위한 치료제를 제조하기에 유용하다. 치료에 대한 참조로 또한 예를 들어 백신접종과 같은, 예방적 치료를 포함한다는 것을 이해하여야 한다. 더구나, 본 발명의 생성물이 사람 환자의 감염 치료를 우선으로 하고 있더라도, 수의학적인 응용도 또한 본 발명의 범주 안에서 고려된다.
본 발명은 나이제리아 메닌지티디스에 관하여 기재하였다. 하지만, 모든 나이제리아 균주, 및 많은 다른 그램-음성 세균 균주는 여기서 동정된 것과 아미노산 서열의 동일성 또는 유사성을 가지는 단백질 또는 관련된 펩티드를 포함하는 것 같다. 상기 펩티드를 함유할 수 있는 미생물은 살모넬라( Salmonella ), 엔테로박터( Enterobacter ), 클렙시엘라 ( Klebsiella ), 쉬겔라( Shigella ) 및 여르시니아( Yersinia)를 포함하지만, 이것에 한정되지는 않는다.
나이제리아 메닌지티디스 균주 B를 사용하여 본 발명의 독성 유전자를 동정하기 위해 실험을 실행하였다. 균주 A의 데이타베이스에서 상동성을 조사하였지만, 균주 B 유래의 단백질 및 유전자가 바람직하다.
바람직하기는, 본 발명의 다양한 관점에서 사용될 수 있는 펩티드는 여기서 정의된 펩티드와 40%이상의 유사성을 가진다. 더욱 바람직하기는, 상기 펩티드는 60%이상의 유사성을 가진다. 가장 바람직하기는 상기 펩티드는 80%이상의, 예를 들어, 95%의 유사성을 가진다. 본 발명에서 정의된 폴리뉴클레오티드 서열에 관하여, 본 발명의 다양한 관점에서 사용될 수 있는 관련 폴리뉴클레오티드는 여기서 정의된 서열과 40%이상의 동일성을 가질 수 있다. 더욱 바람직하기는, 폴리뉴클레오티드 서열은 60%이상의 서열 동일성을 가진다. 가장 바람직하기는, 다중 뉴클레오티드 서열은 80% 이상의 서열 동일성, 예를 들어 95%의 동일성을 가진다.
"유사성" 및 "동일성"이라는 용어는 당 기술 분야에 알려져 있다. "동일성"이라는 용어의 사용은 비교되는 서열에서 상대적으로 동일한 위치 사이에 동일한 짝을 기반으로 하는 서열 대비를 나타낸다. "유사성"이라는 용어는 아미노산 서열 사이의 대비를 나타내는 것으로, 상응하는 위치에서의 동일한 아미노산뿐만 아니라 상응하는 위치에서의 기능적으로 유사한 아미노산도 고려하는 것이다. 그러므로 폴리펩티드 서열 사이의 유사성은 서열 유사성뿐만 아니라 기능의 유사성을 나타낸다.
유전자 서열 사이의 동일성 수준과 아미노산 서열 사이의 동일성 또는 유사성의 수준은 알려진 방법을 사용하여 계산할 수 있다. 본 발명에 관련하여, 동일성 및 유사성을 결정하기 위한 공개적으로 사용 가능한 컴퓨터를 기반으로 한 방법은 BLASTP, BLASTN 및 FASTA(Atschul et al., J. Molec. Biol., 1990;215:403-410), NCBI로부터 사용 가능한 BLASTX 프로그램, 및 Genetics Computer Group, Madison WI사로부터의 Gap 프로그램을 포함한다. 여기서 제공한 유사성 및 동일성의 수준은 아미노산 서열 유사성을 결정하기 위한 12의 갭 페널티(Gap penalty) 및 4의 갭 페널티, 그리고 폴리뉴클레오티드 서열 비교를 위한 50의 갭 페널티 및 3의 갭 페널티를 가지고, Gap 프로그램을 사용하여 얻었다.
본 발명에 따른 유전자를 특성화한다면, 다른 미생물내 관련된 유전자 또는 펩티드를 검색하기 위해 유전자 서열을 사용하는 것이 가능하다. 이것은 예를 들어 EMBL 또는 GenBank와 같은, 현존하는 데이타베이스에서 조사하는 것으로 실행할 수 있다.
본 발명에 따른 펩티드 또는 단백질은 당 기술 분야에 알려진 방법으로 단리하고 정제할 수 있다. 특히, 유전자 서열을 동정한다면, 유전자를 적합한 숙주에 발현시키는 재조합 기술을 사용하는 것이 가능할 것이다. 활성 단편 및 관련된 분자를 동정할 수 있고 치료에 사용할 수 있다. 예를 들어, 상기 펩티드 또는 그들의 활성 단편을 면역 반응을 유도하기 위해, 백신에서 항원 결정자로 사용할 수 있다. 또한, 수동면역, 또는 진단적 응용을 위한, 항체의 제조에 그들을 사용할 수 있다. 적합한 항체는 단일사슬 Fv 단편을 포함하는, 단일클론성 항체, 또는 이의 단편을 포함한다. 항체의 제조를 위한 방법은 당업자들에게는 명확할 것이다.
펩티드의 활성 단편은 펩티드의 생물학적 기능을 유지하는 것이다. 예를 들어, 면역 반응을 일으키기 위해 사용될 때, 단편은 충분한 크기를 가져서, 단편으로부터 생성된 항체가 박테리아 미생물 상에서 그 펩티드와 다른 펩티드를 식별할 것이다. 전형적으로, 상기 단편은 크기가 30개의 뉴클레오티드(10개의 아미노산)이상일 것이고, 바람직하기는 60개의 뉴클레오티드(20개의 아미노산)이상, 그리고 가장 바람직하기는 크기가 90개의 뉴클레오티드(30개의 아미노산)보다 클 것이다.
다른 미생물로부터 관련된 분자에 더하여, 본 발명은 여기서 동정된, 생물학적 기능이 현저하게 변경되지 않은 펩티드 및 폴리뉴클레오티드에 이루어지는 변형 을 포함한다. 당업자들에게는, 유전자 코드의 퇴화가 여기서 열거된 것들로부터 소수염기 변화를 가지는 폴리뉴클레오티드를 나타내지만, 그럼에도 불구하고 같은 펩티드를 코드화한다는 것은 명백한 것이다. 상보적인 폴리뉴클레오티드 또한 본 발명에 속한다. 아미노산 수준에서의 보존적 치환도 또한 고려된다, 즉 다른 산성 또는 염기성 아미노산을 기능의 실질적인 손상없이 치환할 수 있다.
감독된 미생물을 기반으로 하는 백신의 제조는 당업자들에게는 알려져 있다. 백신 조성물은 적합한 운반체 또는 부형제, 예를 들어, 감염에 대하여 효과적인 면역을 제공하기에 필요하거나 또는 원하여지는, 명반과 같은 것으로 제제화 할 수 있다. 백신 제제의 조제는 당업자들에게는 명백할 것이다. 여기서 동정된 유전자 중 어느 하나의 발현을 파괴하는 돌연변이로 감독된 미생물을 제조할 수 있다. 당업자들은 특정 유전자의 발현을 파괴하기 위한 방법을 알고 있을 것이다. 사용될 수 있는 기술은 삽입성 불활성 또는 유전자 결실 기술을 포함한다. 본 발명에 의하여 감독된 미생물은 예를 들어, 여기서 동정된 두 번째 유전자에서 또는 aro돌연변이와 같은 미생물의 성장에 요구되는 분리된 유전자에서, 또는 살모넬라에 관하여, W0-A-96/17951에서 동정된 SPI2 영역에 위치한 유전자에서처럼 다른 유전자에서의 추가적인 돌연변이를 또한 포함할 수 있다.
감독된 미생물은 이종성 항원, 치료 단백질 또는 핵산(DNA 또는 RNA)운반을 위한 운반체 시스템으로 사용될 수도 있다. 이 구현예에서, 생체 내 특정 부위로 이종성 항원, 단백질 또는 핵산을 운반하기 위해 상기 감독된 미생물을 사용한다. 감독된 미생물에 이종성 항원, 펩티드 또는 핵산을 도입하는 것은 예를 들어, 이종 성 항원 또는 치료 단백질을 발현하는 폴리뉴클레오티드를 포함하고, 또한 적당한 프로모터(promoter) 서열을 포함하는, 벡터(vector)와 같은 재조합 구조물의 사용을 포함하는, 전통적인 기술로 실행할 수 있다. 대체 가능하게는, 이종성 항원 또는 단백질을 코드화하는 유전자를 유기체의 게놈 및 발현을 조절하기 위해 사용되는 동종성 프로모터에 결합할 수 있다.
더 일반적으로, 그리고 당업자들에게 잘 알려진 바와 같이, 치료 용도로 적당한 운반체 또는 부형제처럼, 그리고 투여 경로에 맞게 본 발명의 활성 성분의 적당한 양을 선택할 수 있다. 치료될 질환의 기질/심각성, 환자의 종류 및/또는 건강, 등과 같은 알려진 기준에 의하여 이러한 인자들이 선택되거나 또는 결정될 수 있다.
별개의 구현예에서, 본 발명의 생성물을 잠재적 항생제의 동정 또는 독성의 탐지를 위한 선별 평가에 사용할 수 있다. 전형적인 선별 평가(routine screeing assay)는 당업자들에게 알려져 있고, 적절한 방법으로 본 발명의 생성물을 사용하여 적용할 수 있다. 예를 들어, 잠재적인 항균성 활성을 나타내는 표적에 결합하거나 또는 이를 불활성화하는 약효를 가지는, 잠재성 있는 약을 위한 표적으로서 본 발명의 생성물을 사용할 수 있다.
본 발명의 다양한 생성물은 또한 수의학에 응용할 수 있다.
본 발명은 치료용 또는 진단용으로 사용되는, 청구항 제 1항에 정의된 뉴클레오티드 서열 중 어느 하나, 또는 그램(Gram)-음성적인 세균 내의 이들의 동족체 또는 그의 기능성 단편을 포함하는 오페론에 의해 코드화되는 펩티드, 이를 코드하는 유전자, 및 이와 관련된 감독된 미생물를 제공하며, 본 발명에 따른 펩티드, 유전자 및 감독된 미생물은 나이제리아 또는 그램-음성 세균에 의한 감염과 연계된 질환의 치료 또는 예방에 사용될 수 있다.
다음은 독성 유전자를 동정하기 위해 사용한 실험 절차의 간단한 개요이다.
패혈증 감염에 핵심적인 나이제리아 메닌지티디스의 유전자를 기호-태그화 (signature-tagged) 돌연변이법(STM)(Hensel et al., Science, 1995; 269: 400-403)을 사용하여 동정하였다. STM에서, 각각의 돌연변이는 많은 수의 돌연변이가 동시에 분석될 수 있도록 단일한 서열의 식별자로 태그화된다. 하지만, 삽입성 돌연변이의 라이브러리(library)를 구성하는 것이 필요하다는 점에서, 현재까지 N. meningitidis를 연구하는 데 한계가 있다. 상기 돌연변이법은 나이제리아 DNA가 Tn10 치환의 정제된 구성성분을 사용하여 인 비트로에서 변형되는 방법을 사용하여 성공적으로 수행하였다. 나이제리아 메닌지티디스가 외인성 DNA를 효과적으로 받아들이므로, 그 다음 변형된 대립 형질 유전자는 형질 전환(transformation)에 의하여 나이제리아 메닌지티디스로 도입된다. 그런 다음 돌연변이는 전신적인 감염을 야기하는 그들의 능력으로 인하여 선별할 수 있다.
벡터 pSTM115(Sun et al ., Nature Medicine, 2000; 6(11):1269-1273)를 인 비트로 돌연변이법용 트랜스포슨(transposon) 공여체로 사용하였다. 96개의 별도의 전치(transposition) 반응은, 각각이 동일한 기호-태그를 포함한 96개의 pSTM115 유도체를 포함한다. 변형된 게놈 DNA는 회복되고, 형질 전환에 의하여 숙주로 복귀된다. Tn10 삽입이 다양한 위치에서 발생하는가를 결정하기 위해, 40개의 형질전환체를 서던 블라트 분석(Southern blot analysis)에 의한 단일 전치 반응으로 평가하였다. 각각은 단독의, 독특한 Tn10 삽입을 가졌다. Tn10 융합이 유년기 래트(rat)의 전신 감염시 동안 안정한지를 확인하기 위해, 래트를 통한 배양 전후의 6개의 돌연변이의 교잡 패턴을 비교하였다. 감염 전후 동일한 교잡 패턴을 얻었다.
실시된 실험 조건은 다음과 같다.
세균 균주 및 성장;
C311+는 ET-5, 침입적인 수막구균성 감염 환자로부터 분리한 혈청그룹 B 나 이제리아 메닌지티디스이다(Virji et al., Mol. Microbiol., 1991; 5: 1831-1841). 나이제리아 메닌지티디스를 5%의 레빈탈(Levinthal) 보충물이 포함된 뇌-심장 융합 배지에서 생육시켰다. E. coli 균주를 루리아 베르타니(Luria Bertani) 배지에서 증식시켰다. 카나마이신(kanamycin)을 나이제리아 메닌지티디스 및 이. 콜라이(E. coli)의 경우에 각각 75 및 50 ㎍/㎖의 농도가 되도록 고체 배지에 첨가하였다.
인 비트로 전치 및 삽입 위치 특성화:
pSTM115에서 복제의 pACYC184 기시점(起始點)을 사용하여 표지 식별(marker rescue)에 의하여 삽입 위치를 분리하였다. 뉴클레오티드 서열화는 프라이머 NG62(5'-TTGGTTAATTGGTTGTAACACTGG-3')(SEQ ID NO. 209) 또는 NG99(5'-ATTCTCATGTTTGACAGCG-3')(SEQ ID NO. 210)를 가지고 염료종결법(dye-termination method) (Perkin Elmer, Norwalk, Connecticut)을 사용하여 실행하였다. 상동성 조 사는 혈청 A 및 B 나이제리아 메닌지티디스 및 나이제리아 고노리아에(N. gonorrhoeae) 게놈 서열(각각 http://www.sanger.ac.uk/Projects/N_meningitidis 및 http://www.tigr.org 및 http://dna1.chem.ou.edu/gono.html)을 포함하는, 단백질 데이타베이스 (http://www.ncbi.nlm.nih.gov/)에 대하여 수행하였다.
태그 증폭, 클로닝 및 서던 블라트 분석:
도트 블라트(dot blot)의 교잡 및 제조는 태그가 프라이머 NG13 (5'-ATCCTACAACCTCAAGCT-3') (SEQ ID NO. 211) 및 NG14 (5'-ATCCCATTCTAACCAAGC-3') (SEQ ID NO. 212)으로 증식되었고, 플라스미드(plasmid) DNA가 아닌 PCR 생성물이 막에 고정되었다는 것을 제외하고는 상기한 문헌 Hensel et al .에 기재된 대로 수행하였다. 올리고뉴클레오티드 S1 (5'-AAGAGATTACGCGCAGACC-3') (SEQ ID NO. 213) 및 S2 (5'-AATACGCAACCGCCTCTC-3') (SEQ ID NO. 214)는 '기호 태그'에 인접한 pSTM115에서의 서열에 어닐링(annealing)하고, 각각의 pSTM115 유도체로부터 367-염기-쌍 생성물을 증폭하기 위해 사용되었다. 서던 블라트 분석을 위해, pSTM115로부터의 카나마이신 내성 카세트(cassette)는 무작위 프라이머 방법(NEB)을 사용하여 표지되고, Cla1에 의하여 소화되는 게놈 DNA에 대한 탐침자로서 사용되었다.
동물 모델:
STM 풀(pool)을 선별하기 위해, 돌연변이를 각각 미세역가 플레이트 (microtiter plate)에서 18시간 동안 생육하였다. 세균들을 울혈(pool)한 다음, PBS에 재-현탁하였다. 위스타(Wistar) 래트(생후 5일)에 현탁액 100㎕를 복강 내로 접종하고, 48시간 동안 관찰하였다. 돌연변이의 경쟁지수를 확정하기 위해, 야생형 및 돌연변이 세균을 고형 배지에서 18시간 동안 생육하고, PBS로 수집하고, 총 접종물 5x106 CFU로 돌연변이 대 야생형 세포의 비율을 1:1로 하여 래트에 접종하였다. 야생형(카나마이신-민감성) 세균에 대한 돌연변이(카나마이신-내성)의 비율은 복제 샘플을 항생물질이 첨가된 또는 첨가되지 않은 배지에 플레이트화하는 것에 의해 결정되었다.
상동성 조사의 결과를 표 1에 나타낸다.
SEQ ID NO. 단백질 수탁번호 유기체
3 & 4 3'디히드로퀴네이트 신타제 NMB0647 N. gonorrhoeae
25 & 26 글리코실 트랜스퍼라제 LS12 N. gonorrhoeae
35 & 36 다중리보뉴클레오티드 뉴클레오티딜 트랜스퍼라제 NMB0758 N. meningitidis
37 & 38 포스포리보실 포밀 글리신아미드 신타제 PURL E. coli
43 & 44 쉬키메이트 디히드로게나제 AROE N. meningitidis
47 & 48 가설의 21.7 kD 단백질 NMB0673 N. meningitidis
53 & 54 추정의 세포 결합 인자 NMB0345 N. meningitidis
57 & 58 가설의 단백질 HI0633 H. influenzae
61 & 62 Na+/H+ 역운반체 NMBN0536 N. meningitidis
63 & 64 코리스메이트 신타제 AROC V. anguillarum
67 & 68 파라콰트-유도가능 단백질 B PQ15B E. coli
71 & 72 5'-메틸테드라히드로프테로일릴 트리글루타메이트-호모시스테인 메틸 트랜스퍼라제 NMB0944 N. meningitidis
79 & 80 α-1,2 N-아세틸글루코사민 트랜스퍼라제 RFAK N. meningitidis
83 & 84 추정의 RNA 메틸라제 NMB1348 N. meningitidis
89 & 90 L-락테이트 퍼미아제 NMB0543 N. meningitidis
91 & 92 ABC 수송체 NMB1240 N. meningitidis
103 & 104 예상 GTP-결합 단백질 HI0393 H. influenzae
109 & 110 캡슐 다당류 변형 단백질 LIPB N. meningitidis
113 & 114 가설의 17.8 kD 단백질 NMB0734 N. meningitidis
115 & 116 E. coli 가설의 단백질 YIGC S. typhimurium
119 & 120 리보뉴클라제 Ⅲ NMB0686 N. meningitidis
121 & 122 AMPD 단백질 NMB0668 N. meningitidis
123 & 124 5-메틸테드라히드로프테로일릴 트리글루타메이트-호모시스테인 메틸 트랜스퍼라제 NMB0944 N. meningitidis
133 & 134 추정의 ATP-의존 RNA 헬리카제 NMB1422 N. meningitidis
137 & 138 추정의 RNA 메틸라제 NMB1348 N. meningitidis
141 & 142 쉬키메이트 디히드로겐아제 AROE N. meningitidis
143 & 144 추정의 외부 막 단백질 OMPU N. meningitidis
145 & 146 TONB 단백질 TONB N. meningitidis
147 & 148 추정 아포리포단백질 N-아실 트랜스퍼라제 NMB0713 N. meningitidis
149 & 150 트랜스포사제 NMB0991 N. meningitidis
153 & 154 UTP-글루코스-1-포스페이트 유리딜릴트랜스퍼라제 NMB0638 N. meningitidis
157 & 158 ADP 햅토스-LPS 헵토실 트랜스퍼라제Ⅱ NMB1527 N. meningitidis
161 & 162 추정 막-결합 분해 뮤레인 트랜스글리코실라제 B NMB1279 N. meningitidis
171 & 172 추성 세포-결합 인자 NMB0345 N. meningitidis
173 & 174 P-아미노 벤조에이트 신서타제 PABB H. pylori j99
177 & 178 5'-메틸테드라히드로프테로일릴 트리글루타메이트-호모시스테인 메틸 트랜스퍼라제 NMB0944 N. meningitidis
183 & 184 보존된 가설의 단백질 NMB0183 N. meningitidis
185 & 186 E. coli 가설의 단백질 YIGC S. typhi LT2
여기서 동정된 나머지 서열에서는, 상동성의 결과가 얻어지지 않았다.
유전자 생성물을 사용하여 폴리클로날 항체를 생산하고 백신 후보물질로서의 효율성을 평가하기 위해 다양한 나이제리아 메닌지티디스 균주에 대한 엘리자(Elisa) 평가로 시험하였다. 사용된 균주는 다음과 같다:
나이제리아 메닌지티디스 (B) Type 1000
나이제리아 메닌지티디스 (B) Type NGE31
나이제리아 메닌지티디스 (B) Type NGH15
나이제리아 메닌지티디스 (B) Type SW2 107
나이제리아 메닌지티디스 (B) Type NHG38
나이제리아 메닌지티디스 (B) Type NGE28
나이제리아 메닌지티디스 (B) Type 2996
이것은 이들 항체에 의하여 인식되는 나이제리아 메닌지티디스 균주의 다양성에 관하여 정보를 제공한다.
나이제리아 메닌지티디스를 초콜렛색의 말 혈액이 함유된 콜럼비아 아가(Columbia agar)(Oxoid)에서 5%의 CO2 상태의 37℃에서 14시간 동안 생육하였다. 상기 세포를 아가 플레이트에서 긁어내고 50㎖ 튜브에서 PBS 20㎖에 재-현탁하였다. 상기 세포 현탁액에서 세균을 사멸시키기 위해 56℃에서 30분 동안 가열하였다.
가열로 사멸된 나이제리아 메닌지티디스의 샘플 50㎕를 초콜렛색의 말 혈액이 함유된 콜럼비아 아가에 엷게 펼치고, 5%의 CO2상태의 37℃에서 18시간 동안 배양하였다. 이것으로 모든 나이제리아 메닌지티디스 세포가 사멸된 것을 확인할 수 있다. 상기 현탁액의 OD620은 PBS에 대하여 0.1 OD 유니트로 조절된다.
가열로 사멸된 나이제리아 메닌지티디스를 사용한 엘리자
엘리자 평가는 다음의 프로토콜을 사용하고 가열되어 사멸된 나이제리아 메 닌지티디스를 사용하여 실행하였다. 엘리자 플레이트는 가열되어 사멸된 세포(96 웰 플레이트의 각 웰에는 PBS 중 사멸된 세균 50㎕가 첨가되고, 4℃에서 배양된다)로 하룻밤 동안 코팅되었다.
37℃에서 1시간 동안의 배양되면서 표준 엘리자 프로토콜이 이어졌다. PBS/3% BSA 차단액, PBS/Tween 0.1% 세척액, 항-토끼 AP 컨쥬게이트 이차 항체 (Sigma) 및 Sigma Fast P 니트로페닐 포스페이트 탐지 시약(Sigma)을 사용하였다. 데이타는 적절한 미세역가 플레이트 판독기를 사용하여 405㎚에서 판독하였다. 사용된 혈청은 첫 번째 보조투여 백신화 후 7일째에 사용가능하다(첫 번째 백신화 후 35일).
시험된 항체는 SEQ ID NOS. 8, 102, 140, 158 및 202로 동정된 유전자 생성물에 대하여 발생한 항체였다. 각각의 경우에서, 상기 결과는 항혈청이 나이제리아 메닌지티디스 B의 여러 다른 균주를 인식하였다는 것을 나타냈다.
엑스 비보/인 비트로 선별
사람에서 수막구균성 질병에 대한 예방은 나이제리아 메닌지티디스에 대한 살균 항체의 존재와 연계되어 왔다(Goldscheider et al ., J. Exp. Med., 1969; 129: 1307-1326). 또한, 탐지할 수 있는 살균 작용 활성의 존재 및 인 비보 모델에서의 방어 사이의 상호 관계를 나타내는 증거도 있다(참조: Martin, J. Bacteriol., 2000; 83: 27-31). 그러므로, 생성된 항혈청은 생성된 항체의 살균 활성을 평가하기 위하여 사용하였다.
살균성 평가는 전-면역 혈청 및 상응하는 항체 후보물질에 대한 토끼 항혈청으로 수행하였다. 시판 중인 토끼 혈청은 보충물 만을 사멸시켜 제거하는 예비-선별로 이어지는 보충물 공급원으로 사용되었다. Dulbecco's PBS(Gibco)는 필요한 경우에 완충 용액으로 사용하였다. 나이제리아 메닌지티디스 균주 MC58를 평가에 사용하기에 앞서 37℃(5% CO2)에서 14시간 동안 생육하였다.
50㎕ 중의 MC58 200-400 CFU를 일련의 열-불활성화된 혈청 희석물 100㎕을 가진 보충물(50㎕)의 존재 하에서 배양하였다. 0시간에서의 샘플은 초콜렛색의 말 혈액을 포함하는 콜럼비아 아가(Oxoid)에 도포하였다. 60분 동안 배양한 후, 생존 세균의 수는 초콜렛색의 말 혈액을 포함하는 콜럼비아 아가(Oxoid)에 도포하여 평가되었다. 살균 활성은 60분 후에 생존하는 세균을 퍼센트로 환산하여 나타내었다. 모든 샘플을 이중으로 시험하였고, 세번 도포하였다. 모든 적절한 양성 및 음성 대조군을 이용하였다. 각각의 시험 샘플에서, 살균 활성은 실질적으로 전-면역 혈청에서보다 훨씬 컸다.
인 비보 선별법
백신 후보물질의 예방 효능을 평가하기 위해, 성체 마우스를 여기서 SEQ ID NOS. 102 및 108로 동정된 재조합 단백질로 면역화하였고, 방어 반응은 살아 있는 세균의 면역성 검사(challenge)로 결정하였다. 백신 후보물질 각각에 대해, 15마리의 6주령 마우스(6주령 balb/C 마우스)는 3주 간격으로 개별적으로 두번씩 항원 25㎍으로(피하에서) 백신화하였다.
면역화 스케줄이 끝나고 일주일째에, 상기 그룹은 상동의 세균 균주 MC58로 면역성 검사되었다. 세균은 107 cfu를 1회 투여량으로 하여 뇌-심장 혼합/0.5% 철 덱스트란 배지에서 500㎕ 부피로 복강 내에 접종하였다. 이전의 결과는 철이 이러한 동물에서 균혈증 질병의 초기에 필요하다는 것을 보여주었다. 이 모델은 이전에 백신화의 방어 효능을 예증하기 위해 사용되었다(Lissolo et al ., Immujn. 1995; 63: 884-890).
대조군은 부형제 단독(음성 대조군)으로 또는 정제된 PorA이 결합된 부형제(양성 대조군)로 백신화된 동물을 포함한다. PorA는 나이제리아 메닌지티디스에 의해서만 발현되는 외부 막 단백질이고, 외부 막 소포 백신에 의하여 유도되는 살균성 항체를 위한 주 표적이다. PorA에 대한 모노클로날 항체는 또한 유아 래트 모델에서 수동적으로 동물을 보호하는 것을 보여준다. 어쨌든, PorA는 균주들마다 상당히 다양하고, 상동의 균주로 면역 야기되는 경우 약간의 방어를 이끌기는 하지만, 이상적인 백신 후보물질은 아니다. 생존체는 다음의 면역성 검사로 관찰되었다. 음성 대조군은 48시간 후 생존체가 전혀 없는 것으로 나타났다. PorA로 백신화된 경우 72시간에 6마리가 생존하는 것으로 나타났다. SEQ ID NOS. 102 및 108의 단백질로 백신화된 경우는 각각 5마리 및 3마리가 생존하는 것으로 나타났다.
SEQUENCE LISTING <110> Microscience Limited <120> Virulence Gene and Protein, and Their Use <130> REP06436WO <140> not yet known <141> 2001-05-08 <150> 0011108.8 <151> 2000-05-08 <160> 214 <170> PatentIn Ver. 2.1 <210> 1 <211> 1674 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1674) <400> 1 atg ctg acc tat acc ccg ccc gat gcc cgc ccg ccc gcc aaa acc cac 48 Met Leu Thr Tyr Thr Pro Pro Asp Ala Arg Pro Pro Ala Lys Thr His 1 5 10 15 gaa aag ccg tgg ctg ttg ctg ttg atg gcg ttt gcc tgg ttg tgg ccc 96 Glu Lys Pro Trp Leu Leu Leu Leu Met Ala Phe Ala Trp Leu Trp Pro 20 25 30 ggc gtg ttt tcc cac gat ttg tgg aat cct gac gaa cct gcc gtc tat 144 Gly Val Phe Ser His Asp Leu Trp Asn Pro Asp Glu Pro Ala Val Tyr 35 40 45 acc gcc gtc gaa gca ctg gca ggc agc ccc acc cct ttg gtt gcc cat 192 Thr Ala Val Glu Ala Leu Ala Gly Ser Pro Thr Pro Leu Val Ala His 50 55 60 ctg ttc ggt caa atc gat ttc ggc ata ccg ccc gtg tat ctt tgg gtt 240 Leu Phe Gly Gln Ile Asp Phe Gly Ile Pro Pro Val Tyr Leu Trp Val 65 70 75 80 gcc gcc gcg ttc aaa cat ttg ctg tcg ccg tgg gct gcc gac ccg tat 288 Ala Ala Ala Phe Lys His Leu Leu Ser Pro Trp Ala Ala Asp Pro Tyr 85 90 95 gat gcc gca cgc ttt gcc ggc gtg ttt ttc gcc gtt gtc gga ctg act 336 Asp Ala Ala Arg Phe Ala Gly Val Phe Phe Ala Val Val Gly Leu Thr 100 105 110 tcc tgc ggc ttt gcc ggt ttc aac ttt ttg ggc aga cac cac ggg cgc 384 Ser Cys Gly Phe Ala Gly Phe Asn Phe Leu Gly Arg His His Gly Arg 115 120 125 agc gtc gtc ctg att ctc atc ggc tgt atc ggg ctg att ccg acc gta 432 Ser Val Val Leu Ile Leu Ile Gly Cys Ile Gly Leu Ile Pro Thr Val 130 135 140 cac ttt ctc aac ccc gct gcc gcc gcc ttt gcc gcc gcc gga ctg gtg 480 His Phe Leu Asn Pro Ala Ala Ala Ala Phe Ala Ala Ala Gly Leu Val 145 150 155 160 ctg cac ggt tat tct ttg gct cgc cgg cgc gtg att gcc gcc tct ttt 528 Leu His Gly Tyr Ser Leu Ala Arg Arg Arg Val Ile Ala Ala Ser Phe 165 170 175 ctg ctc ggt acg ggt tgg acg ctg atg tcg ttg gca gca gct tat ccg 576 Leu Leu Gly Thr Gly Trp Thr Leu Met Ser Leu Ala Ala Ala Tyr Pro 180 185 190 gcg gca ttt gcc ctg atg ctg ccc ctg ccc gtg ctg atg ttt ttc cgt 624 Ala Ala Phe Ala Leu Met Leu Pro Leu Pro Val Leu Met Phe Phe Arg 195 200 205 ccg tgg caa agc agg cgt ttg atg ttg acg gca gtc gcc tcg ctt gcc 672 Pro Trp Gln Ser Arg Arg Leu Met Leu Thr Ala Val Ala Ser Leu Ala 210 215 220 ttt gcc ctg ccg ctt atg acc gtt tac ccg ctg ctc ttg gca aaa acg 720 Phe Ala Leu Pro Leu Met Thr Val Tyr Pro Leu Leu Leu Ala Lys Thr 225 230 235 240 cag ccc gcg ctg ttc gcg caa tgg ctc gac gat cac gtt ttc ggt acg 768 Gln Pro Ala Leu Phe Ala Gln Trp Leu Asp Asp His Val Phe Gly Thr 245 250 255 ttc ggc ggc gtg cgg cac att cag acg gca ttc agt ttg ttt tac tat 816 Phe Gly Gly Val Arg His Ile Gln Thr Ala Phe Ser Leu Phe Tyr Tyr 260 265 270 ctg aaa aac ctg ctt tgg ttt gca ttg cct gcg ctg ccg ctg gcg gtt 864 Leu Lys Asn Leu Leu Trp Phe Ala Leu Pro Ala Leu Pro Leu Ala Val 275 280 285 tgg acg gtt tgc cgc acg cgc ctg ttt tcg acc gac tgg ggg att ttg 912 Trp Thr Val Cys Arg Thr Arg Leu Phe Ser Thr Asp Trp Gly Ile Leu 290 295 300 ggc gtc gtc tgg atg ctt gcc gtt ttg gtg ctg ctt gcc gtc aat ccg 960 Gly Val Val Trp Met Leu Ala Val Leu Val Leu Leu Ala Val Asn Pro 305 310 315 320 cag cgt ttt cag gat aac ctc gtc tgg ctg ctt ccg ccg ctt gcc ctg 1008 Gln Arg Phe Gln Asp Asn Leu Val Trp Leu Leu Pro Pro Leu Ala Leu 325 330 335 ttc ggc gcg gcg caa ctg gac agc ctg aga cgc ggc gcg gcg gcg ttt 1056 Phe Gly Ala Ala Gln Leu Asp Ser Leu Arg Arg Gly Ala Ala Ala Phe 340 345 350 gtc aac tgg ttc ggc att atg gcg ttc gga ctg ttt gcc gtg ttc ctg 1104 Val Asn Trp Phe Gly Ile Met Ala Phe Gly Leu Phe Ala Val Phe Leu 355 360 365 tgg acg ggc ttt ttc gcc atg aat tac ggc tgg ccc gcc aag ctt gcc 1152 Trp Thr Gly Phe Phe Ala Met Asn Tyr Gly Trp Pro Ala Lys Leu Ala 370 375 380 gaa cgc gcc gcc tat ttc agc ccg tat tat gtt cct gat atc gat ccc 1200 Glu Arg Ala Ala Tyr Phe Ser Pro Tyr Tyr Val Pro Asp Ile Asp Pro 385 390 395 400 att ccg atg gcg gtt gcc gta ctg ttc aca ccc ttg tgg ctg tgg gcg 1248 Ile Pro Met Ala Val Ala Val Leu Phe Thr Pro Leu Trp Leu Trp Ala 405 410 415 att acc cgc aaa aac ata cgc ggc agg cag gcg gtt acc aac tgg gcg 1296 Ile Thr Arg Lys Asn Ile Arg Gly Arg Gln Ala Val Thr Asn Trp Ala 420 425 430 gca ggc gtt acc ctg acc tgg gct ttg ctg atg acg ctg ttc ctg ccg 1344 Ala Gly Val Thr Leu Thr Trp Ala Leu Leu Met Thr Leu Phe Leu Pro 435 440 445 tgg ctg gac gcg gcg aaa agc cac gcg ccc gtc gtc cgg agt atg gag 1392 Trp Leu Asp Ala Ala Lys Ser His Ala Pro Val Val Arg Ser Met Glu 450 455 460 gca tcg ctt tcc ccg gaa tta aaa cgg gag ctt tca gac ggc atc gag 1440 Ala Ser Leu Ser Pro Glu Leu Lys Arg Glu Leu Ser Asp Gly Ile Glu 465 470 475 480 tgt atc gac ata ggc ggc ggc gac cta cac acg cgg att gtt tgg acg 1488 Cys Ile Asp Ile Gly Gly Gly Asp Leu His Thr Arg Ile Val Trp Thr 485 490 495 cag tac ggc aca ttg ccg cac cgc gtc ggc gat gta caa tgc cgc tac 1536 Gln Tyr Gly Thr Leu Pro His Arg Val Gly Asp Val Gln Cys Arg Tyr 500 505 510 cgc atc gtc cgc ttg ccc caa aac gcg gat gcg ccg caa ggc tgg cag 1584 Arg Ile Val Arg Leu Pro Gln Asn Ala Asp Ala Pro Gln Gly Trp Gln 515 520 525 acg gtc tgg cag ggt gcg cgc ccg cgc aac aaa gac agt aag ttc gca 1632 Thr Val Trp Gln Gly Ala Arg Pro Arg Asn Lys Asp Ser Lys Phe Ala 530 535 540 ctg ata cgg aaa acc ggg gaa aat ata tta aaa aca aca gat 1674 Leu Ile Arg Lys Thr Gly Glu Asn Ile Leu Lys Thr Thr Asp 545 550 555 <210> 2 <211> 558 <212> PRT <213> Neisseria meningitidis <400> 2 Met Leu Thr Tyr Thr Pro Pro Asp Ala Arg Pro Pro Ala Lys Thr His 1 5 10 15 Glu Lys Pro Trp Leu Leu Leu Leu Met Ala Phe Ala Trp Leu Trp Pro 20 25 30 Gly Val Phe Ser His Asp Leu Trp Asn Pro Asp Glu Pro Ala Val Tyr 35 40 45 Thr Ala Val Glu Ala Leu Ala Gly Ser Pro Thr Pro Leu Val Ala His 50 55 60 Leu Phe Gly Gln Ile Asp Phe Gly Ile Pro Pro Val Tyr Leu Trp Val 65 70 75 80 Ala Ala Ala Phe Lys His Leu Leu Ser Pro Trp Ala Ala Asp Pro Tyr 85 90 95 Asp Ala Ala Arg Phe Ala Gly Val Phe Phe Ala Val Val Gly Leu Thr 100 105 110 Ser Cys Gly Phe Ala Gly Phe Asn Phe Leu Gly Arg His His Gly Arg 115 120 125 Ser Val Val Leu Ile Leu Ile Gly Cys Ile Gly Leu Ile Pro Thr Val 130 135 140 His Phe Leu Asn Pro Ala Ala Ala Ala Phe Ala Ala Ala Gly Leu Val 145 150 155 160 Leu His Gly Tyr Ser Leu Ala Arg Arg Arg Val Ile Ala Ala Ser Phe 165 170 175 Leu Leu Gly Thr Gly Trp Thr Leu Met Ser Leu Ala Ala Ala Tyr Pro 180 185 190 Ala Ala Phe Ala Leu Met Leu Pro Leu Pro Val Leu Met Phe Phe Arg 195 200 205 Pro Trp Gln Ser Arg Arg Leu Met Leu Thr Ala Val Ala Ser Leu Ala 210 215 220 Phe Ala Leu Pro Leu Met Thr Val Tyr Pro Leu Leu Leu Ala Lys Thr 225 230 235 240 Gln Pro Ala Leu Phe Ala Gln Trp Leu Asp Asp His Val Phe Gly Thr 245 250 255 Phe Gly Gly Val Arg His Ile Gln Thr Ala Phe Ser Leu Phe Tyr Tyr 260 265 270 Leu Lys Asn Leu Leu Trp Phe Ala Leu Pro Ala Leu Pro Leu Ala Val 275 280 285 Trp Thr Val Cys Arg Thr Arg Leu Phe Ser Thr Asp Trp Gly Ile Leu 290 295 300 Gly Val Val Trp Met Leu Ala Val Leu Val Leu Leu Ala Val Asn Pro 305 310 315 320 Gln Arg Phe Gln Asp Asn Leu Val Trp Leu Leu Pro Pro Leu Ala Leu 325 330 335 Phe Gly Ala Ala Gln Leu Asp Ser Leu Arg Arg Gly Ala Ala Ala Phe 340 345 350 Val Asn Trp Phe Gly Ile Met Ala Phe Gly Leu Phe Ala Val Phe Leu 355 360 365 Trp Thr Gly Phe Phe Ala Met Asn Tyr Gly Trp Pro Ala Lys Leu Ala 370 375 380 Glu Arg Ala Ala Tyr Phe Ser Pro Tyr Tyr Val Pro Asp Ile Asp Pro 385 390 395 400 Ile Pro Met Ala Val Ala Val Leu Phe Thr Pro Leu Trp Leu Trp Ala 405 410 415 Ile Thr Arg Lys Asn Ile Arg Gly Arg Gln Ala Val Thr Asn Trp Ala 420 425 430 Ala Gly Val Thr Leu Thr Trp Ala Leu Leu Met Thr Leu Phe Leu Pro 435 440 445 Trp Leu Asp Ala Ala Lys Ser His Ala Pro Val Val Arg Ser Met Glu 450 455 460 Ala Ser Leu Ser Pro Glu Leu Lys Arg Glu Leu Ser Asp Gly Ile Glu 465 470 475 480 Cys Ile Asp Ile Gly Gly Gly Asp Leu His Thr Arg Ile Val Trp Thr 485 490 495 Gln Tyr Gly Thr Leu Pro His Arg Val Gly Asp Val Gln Cys Arg Tyr 500 505 510 Arg Ile Val Arg Leu Pro Gln Asn Ala Asp Ala Pro Gln Gly Trp Gln 515 520 525 Thr Val Trp Gln Gly Ala Arg Pro Arg Asn Lys Asp Ser Lys Phe Ala 530 535 540 Leu Ile Arg Lys Thr Gly Glu Asn Ile Leu Lys Thr Thr Asp 545 550 555 <210> 3 <211> 1077 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1077) <400> 3 atg aaa aca ctg acc gta cac acc ccg tcc cac agc tac ccc atc ttt 48 Met Lys Thr Leu Thr Val His Thr Pro Ser His Ser Tyr Pro Ile Phe 1 5 10 15 atc ggc aac gga ctg ctg ccg cag gca gga agc ctg ctc aaa ccg cat 96 Ile Gly Asn Gly Leu Leu Pro Gln Ala Gly Ser Leu Leu Lys Pro His 20 25 30 ttg ggc aaa cgc gcc gcc atc atc acc aac gaa acc gtc gcc ccg ctc 144 Leu Gly Lys Arg Ala Ala Ile Ile Thr Asn Glu Thr Val Ala Pro Leu 35 40 45 tac ctc ggc acg ctt cag acg gca ttg gat gcg gca ggc gta tcc cat 192 Tyr Leu Gly Thr Leu Gln Thr Ala Leu Asp Ala Ala Gly Val Ser His 50 55 60 ttc agc atc atc ctg ccc gac ggc gag gcg cac aaa aac tgg cag acg 240 Phe Ser Ile Ile Leu Pro Asp Gly Glu Ala His Lys Asn Trp Gln Thr 65 70 75 80 ctc aac ctc atc ttt gac ggg ctg atg caa aac cgc gcc gaa cgc aaa 288 Leu Asn Leu Ile Phe Asp Gly Leu Met Gln Asn Arg Ala Glu Arg Lys 85 90 95 acc acg ctc atc gca ctg ggc ggc ggc gtg atc ggc gat atg acg ggt 336 Thr Thr Leu Ile Ala Leu Gly Gly Gly Val Ile Gly Asp Met Thr Gly 100 105 110 ttt gcg gcg gct act tat caa cgc ggc gcg cca ttt gtt caa att ccc 384 Phe Ala Ala Ala Thr Tyr Gln Arg Gly Ala Pro Phe Val Gln Ile Pro 115 120 125 act act tta tta agt cag gtc gat tcc tcc gtc ggc ggc aaa acc gcc 432 Thr Thr Leu Leu Ser Gln Val Asp Ser Ser Val Gly Gly Lys Thr Ala 130 135 140 atc aac cac ccg ctc ggc aaa aat atg atc ggc gcg ttc tac cag ccg 480 Ile Asn His Pro Leu Gly Lys Asn Met Ile Gly Ala Phe Tyr Gln Pro 145 150 155 160 cag gcg gtg ctt gcc gac ttg gac acg ctg cac acc ctg ccc gcc cgc 528 Gln Ala Val Leu Ala Asp Leu Asp Thr Leu His Thr Leu Pro Ala Arg 165 170 175 gaa ctg tcc gcc ggt atg gcg gaa gtc atc aaa tac ggc acg ctc ggc 576 Glu Leu Ser Ala Gly Met Ala Glu Val Ile Lys Tyr Gly Thr Leu Gly 180 185 190 gac att agt ttt ttt gaa tgg ctg gaa cag cat atg ccc gaa ctg atg 624 Asp Ile Ser Phe Phe Glu Trp Leu Glu Gln His Met Pro Glu Leu Met 195 200 205 gca ctc gaa cgc gcg ccc ctc atc caa gcc gtg tac cgc tgt tgc caa 672 Ala Leu Glu Arg Ala Pro Leu Ile Gln Ala Val Tyr Arg Cys Cys Gln 210 215 220 atg aag gca gac atc gtc gcc caa gac gaa acc gaa cag ggc ata cgc 720 Met Lys Ala Asp Ile Val Ala Gln Asp Glu Thr Glu Gln Gly Ile Arg 225 230 235 240 gca tgg ctc aac ctc gga cac acc ttc gga cac gcc att gaa acc gag 768 Ala Trp Leu Asn Leu Gly His Thr Phe Gly His Ala Ile Glu Thr Glu 245 250 255 atg ggt tac ggt act tgg ctg cac ggc gag gcc gtc gcc gcc ggc tgc 816 Met Gly Tyr Gly Thr Trp Leu His Gly Glu Ala Val Ala Ala Gly Cys 260 265 270 gtg ttg gcg gcg cgt ttg tcc gaa caa ctg ggc aaa atc tcc gcc gca 864 Val Leu Ala Ala Arg Leu Ser Glu Gln Leu Gly Lys Ile Ser Ala Ala 275 280 285 gat acc gcg cgg ctc gcc gcc ctg ctc gaa gcc gcc gga ctg ccg tcc 912 Asp Thr Ala Arg Leu Ala Ala Leu Leu Glu Ala Ala Gly Leu Pro Ser 290 295 300 gcg cca ccc gtg ttt gcc ttt gaa aaa tgg ctg gaa cac atg agc cac 960 Ala Pro Pro Val Phe Ala Phe Glu Lys Trp Leu Glu His Met Ser His 305 310 315 320 gat aaa aaa gtc agc ggc ggc atc atg cgc ttt atc ggt ctg aac cgg 1008 Asp Lys Lys Val Ser Gly Gly Ile Met Arg Phe Ile Gly Leu Asn Arg 325 330 335 ctg ggc gaa gcc aac atc acc gaa att acc gac acg gac atc ctc cgc 1056 Leu Gly Glu Ala Asn Ile Thr Glu Ile Thr Asp Thr Asp Ile Leu Arg 340 345 350 cgc acc ctg caa ccg tat ctc 1077 Arg Thr Leu Gln Pro Tyr Leu 355 <210> 4 <211> 359 <212> PRT <213> Neisseria meningitidis <400> 4 Met Lys Thr Leu Thr Val His Thr Pro Ser His Ser Tyr Pro Ile Phe 1 5 10 15 Ile Gly Asn Gly Leu Leu Pro Gln Ala Gly Ser Leu Leu Lys Pro His 20 25 30 Leu Gly Lys Arg Ala Ala Ile Ile Thr Asn Glu Thr Val Ala Pro Leu 35 40 45 Tyr Leu Gly Thr Leu Gln Thr Ala Leu Asp Ala Ala Gly Val Ser His 50 55 60 Phe Ser Ile Ile Leu Pro Asp Gly Glu Ala His Lys Asn Trp Gln Thr 65 70 75 80 Leu Asn Leu Ile Phe Asp Gly Leu Met Gln Asn Arg Ala Glu Arg Lys 85 90 95 Thr Thr Leu Ile Ala Leu Gly Gly Gly Val Ile Gly Asp Met Thr Gly 100 105 110 Phe Ala Ala Ala Thr Tyr Gln Arg Gly Ala Pro Phe Val Gln Ile Pro 115 120 125 Thr Thr Leu Leu Ser Gln Val Asp Ser Ser Val Gly Gly Lys Thr Ala 130 135 140 Ile Asn His Pro Leu Gly Lys Asn Met Ile Gly Ala Phe Tyr Gln Pro 145 150 155 160 Gln Ala Val Leu Ala Asp Leu Asp Thr Leu His Thr Leu Pro Ala Arg 165 170 175 Glu Leu Ser Ala Gly Met Ala Glu Val Ile Lys Tyr Gly Thr Leu Gly 180 185 190 Asp Ile Ser Phe Phe Glu Trp Leu Glu Gln His Met Pro Glu Leu Met 195 200 205 Ala Leu Glu Arg Ala Pro Leu Ile Gln Ala Val Tyr Arg Cys Cys Gln 210 215 220 Met Lys Ala Asp Ile Val Ala Gln Asp Glu Thr Glu Gln Gly Ile Arg 225 230 235 240 Ala Trp Leu Asn Leu Gly His Thr Phe Gly His Ala Ile Glu Thr Glu 245 250 255 Met Gly Tyr Gly Thr Trp Leu His Gly Glu Ala Val Ala Ala Gly Cys 260 265 270 Val Leu Ala Ala Arg Leu Ser Glu Gln Leu Gly Lys Ile Ser Ala Ala 275 280 285 Asp Thr Ala Arg Leu Ala Ala Leu Leu Glu Ala Ala Gly Leu Pro Ser 290 295 300 Ala Pro Pro Val Phe Ala Phe Glu Lys Trp Leu Glu His Met Ser His 305 310 315 320 Asp Lys Lys Val Ser Gly Gly Ile Met Arg Phe Ile Gly Leu Asn Arg 325 330 335 Leu Gly Glu Ala Asn Ile Thr Glu Ile Thr Asp Thr Asp Ile Leu Arg 340 345 350 Arg Thr Leu Gln Pro Tyr Leu 355 <210> 5 <211> 1053 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1053) <400> 5 atg aca cac cat tac ccc aca gac gat att aag att aaa gaa gtt aaa 48 Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys 1 5 10 15 gag ttg ttg ccg ccg att gcc cat ctt tac gag ctg ccg att tcc aaa 96 Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys 20 25 30 gag gct tcg ggc ttg gtt cac cgc acc cgt cag gaa att tcc gat ttg 144 Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu 35 40 45 gtt cac ggc agg gac aag cgg ctg ttg gtt att atc ggg ccg tgt tcg 192 Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser 50 55 60 att cac gat ccg aaa gcg gcg ttg gaa tat gcg gag cgt ttg ttg aaa 240 Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys 65 70 75 80 ctc cgc aag cag tat gaa aac gag ctt ttg att gtg atg cgc gtt tat 288 Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr 85 90 95 ttc gag aag ccg agg acg acg gtg ggt tgg aaa ggt ttg att aac gac 336 Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp 100 105 110 ccg cat ttg gac ggt acg ttt gac atc aat ttc ggt ttg cgt cag gca 384 Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala 115 120 125 cgc agc ctg ttg ttg tcg ctg aac aat atg ggt atg cct gcc tct acc 432 Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr 130 135 140 gag ttt ttg gat atg att acg ccg caa tat tat gcg gac ttg att tct 480 Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser 145 150 155 160 tgg ggg gca atc ggc gcg cgg acg acc gaa agc caa gtt cac cgc gaa 528 Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu 165 170 175 ttg gca agc ggg ctg tcc tgc ccc gtc ggc ttt aaa aac ggt acg gat 576 Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp 180 185 190 ggc aat ttg aag att gcc atc gac gca atc ggt gcg gcg agc cat tcg 624 Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser 195 200 205 cat cat ttc ctg tct gta acc aag gcc ggg cat tcc gcc att gtc cat 672 His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His 210 215 220 acc ggc ggc aat cct gac tgt cat gtc att ttg cgc ggc gga aaa gag 720 Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu 225 230 235 240 ccg aat tat gat gcg gga cac gtc agc gag gcg gcg gaa caa ctg cgt 768 Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg 245 250 255 gcg gca ggc gta acc gac aag ctg atg att gat tgc agc cac gcc aac 816 Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn 260 265 270 agc cgc aag gat tac acc cga cag atg gaa gtg gcg caa gac att gcc 864 Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala 275 280 285 gcc caa ttg gaa cag gac ggc ggc aat att atg ggc gtg atg gtg gaa 912 Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu 290 295 300 agc cat ttg gtc gaa ggc agg cag gac aag ccg gaa gtg tac ggc aaa 960 Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys 305 310 315 320 agc att acc gat gcg tgt att ggt tgg gac gcg act gaa gaa ctg ttg 1008 Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu 325 330 335 gca ttg ttg gca ggt gca aac aaa aaa cgt atg gcg cgc gcc ggt 1053 Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala Gly 340 345 350 <210> 6 <211> 351 <212> PRT <213> Neisseria meningitidis <400> 6 Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys 1 5 10 15 Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys 20 25 30 Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu 35 40 45 Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser 50 55 60 Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys 65 70 75 80 Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr 85 90 95 Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp 100 105 110 Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala 115 120 125 Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr 130 135 140 Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser 145 150 155 160 Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu 165 170 175 Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp 180 185 190 Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser 195 200 205 His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His 210 215 220 Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu 225 230 235 240 Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg 245 250 255 Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn 260 265 270 Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala 275 280 285 Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu 290 295 300 Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys 305 310 315 320 Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu 325 330 335 Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala Gly 340 345 350 <210> 7 <211> 1686 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1686) <400> 7 atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag 48 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc 96 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac 144 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg 192 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att 240 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac 288 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg 336 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc 384 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc 432 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc 480 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt 528 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc 576 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att 624 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg 672 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg 720 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac 768 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg 816 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt 864 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc 912 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa 960 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa 1008 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc 1056 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga 1104 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg 1152 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg 1200 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc 1248 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg 1296 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc 1344 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg 1392 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac 1440 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg 1488 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg 1536 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc 1584 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga 1632 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc 1680 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 gta gca 1686 Val Ala <210> 8 <211> 562 <212> PRT <213> Neisseria meningitidis <400> 8 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 Val Ala <210> 9 <211> 1632 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1632) <400> 9 atg ata aaa ccg aac ctg agg ccg aag ctc ggc tct tcc gcg ctg att 48 Met Ile Lys Pro Asn Leu Arg Pro Lys Leu Gly Ser Ser Ala Leu Ile 1 5 10 15 gcc ttc ctt tcc ctg tat tcc tcg ctg gta ttg aat tac gcc ttt ttt 96 Ala Phe Leu Ser Leu Tyr Ser Ser Leu Val Leu Asn Tyr Ala Phe Phe 20 25 30 gcc aaa gtt gtc gag ctt cat cct ttt aac ggc acc ggg gcg gat atc 144 Ala Lys Val Val Glu Leu His Pro Phe Asn Gly Thr Gly Ala Asp Ile 35 40 45 ttc ctc tat acg atg ccg gtg gtg ctg ttt ttt tta agt aat ttc gtt 192 Phe Leu Tyr Thr Met Pro Val Val Leu Phe Phe Leu Ser Asn Phe Val 50 55 60 ttt cac gtc att gcc ctg cct ttc gtg cat aag gta ttg att ccg ttg 240 Phe His Val Ile Ala Leu Pro Phe Val His Lys Val Leu Ile Pro Leu 65 70 75 80 ata ttg gtt atc agt gcg gcg gtg tct tac caa gaa ata ttt ttc aat 288 Ile Leu Val Ile Ser Ala Ala Val Ser Tyr Gln Glu Ile Phe Phe Asn 85 90 95 atc tat ttc aac aag tcg atg ttg aat aat gtc ttg caa act acg gct 336 Ile Tyr Phe Asn Lys Ser Met Leu Asn Asn Val Leu Gln Thr Thr Ala 100 105 110 gcc gaa agc gcg cgc ctg att acg ccg ggc tat gtg ctg tgg att gta 384 Ala Glu Ser Ala Arg Leu Ile Thr Pro Gly Tyr Val Leu Trp Ile Val 115 120 125 tgt ttg ggc gta ttg ccc gcg ctg gcg tat atc gcc gtc aag gtt aaa 432 Cys Leu Gly Val Leu Pro Ala Leu Ala Tyr Ile Ala Val Lys Val Lys 130 135 140 tac cgc gtt tgg tat aag gag ctt ttg acg cgc ctt gtg ctt gcc gcc 480 Tyr Arg Val Trp Tyr Lys Glu Leu Leu Thr Arg Leu Val Leu Ala Ala 145 150 155 160 gtt tcc ttt ttg tgc gcg ttg ggc atc gca atg ttg caa tat cag gat 528 Val Ser Phe Leu Cys Ala Leu Gly Ile Ala Met Leu Gln Tyr Gln Asp 165 170 175 tac gcc tcg ttt ttc cgc aac aat aaa tca gta acc cat ctg att gtg 576 Tyr Ala Ser Phe Phe Arg Asn Asn Lys Ser Val Thr His Leu Ile Val 180 185 190 cca tct aat ttc atc ggc gcg ggc gtg tcg aaa tac aaa gat tgg aag 624 Pro Ser Asn Phe Ile Gly Ala Gly Val Ser Lys Tyr Lys Asp Trp Lys 195 200 205 cgt tcc aat att cct tat acg caa ttg gat atg gcg gtc gtg caa aac 672 Arg Ser Asn Ile Pro Tyr Thr Gln Leu Asp Met Ala Val Val Gln Asn 210 215 220 cgc ccg gcc ggc agc ctg cgc cgt ttc gtg gtg ctg gtc gtg ggc gag 720 Arg Pro Ala Gly Ser Leu Arg Arg Phe Val Val Leu Val Val Gly Glu 225 230 235 240 acc acg cgt gcc gcc aac tgg ggt ttg aac ggt tac agc cgc caa act 768 Thr Thr Arg Ala Ala Asn Trp Gly Leu Asn Gly Tyr Ser Arg Gln Thr 245 250 255 acg ccg ctg ctt gcc gcg cgc ggc gat gaa att gtc aat ttc ccg cag 816 Thr Pro Leu Leu Ala Ala Arg Gly Asp Glu Ile Val Asn Phe Pro Gln 260 265 270 gtc aga agc tgc ggt aca tcg acc gcg cac tcc ctg ccg tgt atg ttc 864 Val Arg Ser Cys Gly Thr Ser Thr Ala His Ser Leu Pro Cys Met Phe 275 280 285 tca acc ttc gac cgc acg gat tat gac gaa atc aaa gcc gaa cac caa 912 Ser Thr Phe Asp Arg Thr Asp Tyr Asp Glu Ile Lys Ala Glu His Gln 290 295 300 gac aac ctg ctg gac atc gtg cag cgc gcc ggc gtg gaa gtt acc tgg 960 Asp Asn Leu Leu Asp Ile Val Gln Arg Ala Gly Val Glu Val Thr Trp 305 310 315 320 ttg gaa aac gat tcc ggc tgc aag ggc gtg tgc ggc aaa gtg ccg aat 1008 Leu Glu Asn Asp Ser Gly Cys Lys Gly Val Cys Gly Lys Val Pro Asn 325 330 335 acc gac gtt acc tcg ctc aac ctg ccc gaa tac tgc cgc aac ggc gag 1056 Thr Asp Val Thr Ser Leu Asn Leu Pro Glu Tyr Cys Arg Asn Gly Glu 340 345 350 tgc ctc gac aat atc ctg ctg acc aag ttc gac gaa gtc ctc aac aaa 1104 Cys Leu Asp Asn Ile Leu Leu Thr Lys Phe Asp Glu Val Leu Asn Lys 355 360 365 aac gat aaa gac gcg gtt tta atc ctg cat acc atc ggc agc cac ggg 1152 Asn Asp Lys Asp Ala Val Leu Ile Leu His Thr Ile Gly Ser His Gly 370 375 380 ccg acg tat tac gaa cgc tat acc gaa gcc gaa cgc aaa ttc acg ccg 1200 Pro Thr Tyr Tyr Glu Arg Tyr Thr Glu Ala Glu Arg Lys Phe Thr Pro 385 390 395 400 acc tgc gac acc aac gaa atc aac aaa tgc acc cgc gcc acg ctg gtc 1248 Thr Cys Asp Thr Asn Glu Ile Asn Lys Cys Thr Arg Ala Thr Leu Val 405 410 415 aac act tac gac aat acg gtt ttg tat gtg gac cag ttt atc gac aag 1296 Asn Thr Tyr Asp Asn Thr Val Leu Tyr Val Asp Gln Phe Ile Asp Lys 420 425 430 gtt atc cgc aaa ctt gaa aac cgc gac gat ttg gaa agc gtg gtg cat 1344 Val Ile Arg Lys Leu Glu Asn Arg Asp Asp Leu Glu Ser Val Val His 435 440 445 tat gtt tcc gac cac ggc gaa agt ttg ggc gaa aac ggg atg tac ctg 1392 Tyr Val Ser Asp His Gly Glu Ser Leu Gly Glu Asn Gly Met Tyr Leu 450 455 460 cac gcc gcg cct tac gcc atc gcg cct tcc ggg cag acg cat atc ccg 1440 His Ala Ala Pro Tyr Ala Ile Ala Pro Ser Gly Gln Thr His Ile Pro 465 470 475 480 atg gtt atg tgg ttt tcc aaa gcc ttc cgc caa cac ggg ggc ata gat 1488 Met Val Met Trp Phe Ser Lys Ala Phe Arg Gln His Gly Gly Ile Asp 485 490 495 ttc caa tgc ctc aaa caa aaa gcg gcg gaa aac gaa tat tcg cac gac 1536 Phe Gln Cys Leu Lys Gln Lys Ala Ala Glu Asn Glu Tyr Ser His Asp 500 505 510 cac tat ttc agc acg gta ttg ggg ctg atg gac att tcc aac agc caa 1584 His Tyr Phe Ser Thr Val Leu Gly Leu Met Asp Ile Ser Asn Ser Gln 515 520 525 acc tat cgg aag gaa atg gat ata ttg gca gcc tgc cgc cgt ccg cgc 1632 Thr Tyr Arg Lys Glu Met Asp Ile Leu Ala Ala Cys Arg Arg Pro Arg 530 535 540 <210> 10 <211> 544 <212> PRT <213> Neisseria meningitidis <400> 10 Met Ile Lys Pro Asn Leu Arg Pro Lys Leu Gly Ser Ser Ala Leu Ile 1 5 10 15 Ala Phe Leu Ser Leu Tyr Ser Ser Leu Val Leu Asn Tyr Ala Phe Phe 20 25 30 Ala Lys Val Val Glu Leu His Pro Phe Asn Gly Thr Gly Ala Asp Ile 35 40 45 Phe Leu Tyr Thr Met Pro Val Val Leu Phe Phe Leu Ser Asn Phe Val 50 55 60 Phe His Val Ile Ala Leu Pro Phe Val His Lys Val Leu Ile Pro Leu 65 70 75 80 Ile Leu Val Ile Ser Ala Ala Val Ser Tyr Gln Glu Ile Phe Phe Asn 85 90 95 Ile Tyr Phe Asn Lys Ser Met Leu Asn Asn Val Leu Gln Thr Thr Ala 100 105 110 Ala Glu Ser Ala Arg Leu Ile Thr Pro Gly Tyr Val Leu Trp Ile Val 115 120 125 Cys Leu Gly Val Leu Pro Ala Leu Ala Tyr Ile Ala Val Lys Val Lys 130 135 140 Tyr Arg Val Trp Tyr Lys Glu Leu Leu Thr Arg Leu Val Leu Ala Ala 145 150 155 160 Val Ser Phe Leu Cys Ala Leu Gly Ile Ala Met Leu Gln Tyr Gln Asp 165 170 175 Tyr Ala Ser Phe Phe Arg Asn Asn Lys Ser Val Thr His Leu Ile Val 180 185 190 Pro Ser Asn Phe Ile Gly Ala Gly Val Ser Lys Tyr Lys Asp Trp Lys 195 200 205 Arg Ser Asn Ile Pro Tyr Thr Gln Leu Asp Met Ala Val Val Gln Asn 210 215 220 Arg Pro Ala Gly Ser Leu Arg Arg Phe Val Val Leu Val Val Gly Glu 225 230 235 240 Thr Thr Arg Ala Ala Asn Trp Gly Leu Asn Gly Tyr Ser Arg Gln Thr 245 250 255 Thr Pro Leu Leu Ala Ala Arg Gly Asp Glu Ile Val Asn Phe Pro Gln 260 265 270 Val Arg Ser Cys Gly Thr Ser Thr Ala His Ser Leu Pro Cys Met Phe 275 280 285 Ser Thr Phe Asp Arg Thr Asp Tyr Asp Glu Ile Lys Ala Glu His Gln 290 295 300 Asp Asn Leu Leu Asp Ile Val Gln Arg Ala Gly Val Glu Val Thr Trp 305 310 315 320 Leu Glu Asn Asp Ser Gly Cys Lys Gly Val Cys Gly Lys Val Pro Asn 325 330 335 Thr Asp Val Thr Ser Leu Asn Leu Pro Glu Tyr Cys Arg Asn Gly Glu 340 345 350 Cys Leu Asp Asn Ile Leu Leu Thr Lys Phe Asp Glu Val Leu Asn Lys 355 360 365 Asn Asp Lys Asp Ala Val Leu Ile Leu His Thr Ile Gly Ser His Gly 370 375 380 Pro Thr Tyr Tyr Glu Arg Tyr Thr Glu Ala Glu Arg Lys Phe Thr Pro 385 390 395 400 Thr Cys Asp Thr Asn Glu Ile Asn Lys Cys Thr Arg Ala Thr Leu Val 405 410 415 Asn Thr Tyr Asp Asn Thr Val Leu Tyr Val Asp Gln Phe Ile Asp Lys 420 425 430 Val Ile Arg Lys Leu Glu Asn Arg Asp Asp Leu Glu Ser Val Val His 435 440 445 Tyr Val Ser Asp His Gly Glu Ser Leu Gly Glu Asn Gly Met Tyr Leu 450 455 460 His Ala Ala Pro Tyr Ala Ile Ala Pro Ser Gly Gln Thr His Ile Pro 465 470 475 480 Met Val Met Trp Phe Ser Lys Ala Phe Arg Gln His Gly Gly Ile Asp 485 490 495 Phe Gln Cys Leu Lys Gln Lys Ala Ala Glu Asn Glu Tyr Ser His Asp 500 505 510 His Tyr Phe Ser Thr Val Leu Gly Leu Met Asp Ile Ser Asn Ser Gln 515 520 525 Thr Tyr Arg Lys Glu Met Asp Ile Leu Ala Ala Cys Arg Arg Pro Arg 530 535 540 <210> 11 <211> 1052 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1050) <400> 11 atg aca cac cat tac ccc aca gac gat att aag att aaa gaa gtt aaa 48 Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys 1 5 10 15 gag ttg ttg ccg ccg att gcc cat ctt tac gag ctg ccg att tcc aaa 96 Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys 20 25 30 gag gct tcg ggc ttg gtt cac cgc acc cgt cag gaa att tcc gat ttg 144 Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu 35 40 45 gtt cac ggc agg gac aag cgg ctg ttg gtt att atc ggg ccg tgt tcg 192 Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser 50 55 60 att cac gat ccg aaa gcg gcg ttg gaa tat gcg gag cgt ttg ttg aaa 240 Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys 65 70 75 80 ctc cgc aag cag tat gaa aac gag ctt ttg att gtg atg cgc gtt tat 288 Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr 85 90 95 ttc gag aag ccg agg acg acg gtg ggt tgg aaa ggt ttg att aac gac 336 Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp 100 105 110 ccg cat ttg gac ggt acg ttt gac atc aat ttc ggt ttg cgt cag gca 384 Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala 115 120 125 cgc agc ctg ttg ttg tcg ctg aac aat atg ggt atg cct gcc tct acc 432 Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr 130 135 140 gag ttt ttg gat atg att acg ccg caa tat tat gcg gac ttg att tct 480 Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser 145 150 155 160 tgg ggg gca atc ggc gcg cgg acg acc gaa agc caa gtt cac cgc gaa 528 Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu 165 170 175 ttg gca agc ggg ctg tcc tgc ccc gtc ggc ttt aaa aac ggt acg gat 576 Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp 180 185 190 ggc aat ttg aag att gcc atc gac gca atc ggt gcg gcg agc cat tcg 624 Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser 195 200 205 cat cat ttc ctg tct gta acc aag gcc ggg cat tcc gcc att gtc cat 672 His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His 210 215 220 acc ggc ggc aat cct gac tgt cat gtc att ttg cgc ggc gga aaa gag 720 Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu 225 230 235 240 ccg aat tat gat gcg gga cac gtc agc gag gcg gcg gaa caa ctg cgt 768 Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg 245 250 255 gcg gca ggc gta acc gac aag ctg atg att gat tgc agc cac gcc aac 816 Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn 260 265 270 agc cgc aag gat tac acc cga cag atg gaa gtg gcg caa gac att gcc 864 Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala 275 280 285 gcc caa ttg gaa cag gac ggc ggc aat att atg ggc gtg atg gtg gaa 912 Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu 290 295 300 agc cat ttg gtc gaa ggc agg cag gac aag ccg gaa gtg tac ggc aaa 960 Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys 305 310 315 320 agc att acc gat gcg tgt att ggt tgg gac gcg act gaa gaa ctg ttg 1008 Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu 325 330 335 gca ttg ttg gca ggt gca aac aaa aaa cgt atg gcg cgc gcc gg 1052 Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala 340 345 350 <210> 12 <211> 350 <212> PRT <213> Neisseria meningitidis <400> 12 Met Thr His His Tyr Pro Thr Asp Asp Ile Lys Ile Lys Glu Val Lys 1 5 10 15 Glu Leu Leu Pro Pro Ile Ala His Leu Tyr Glu Leu Pro Ile Ser Lys 20 25 30 Glu Ala Ser Gly Leu Val His Arg Thr Arg Gln Glu Ile Ser Asp Leu 35 40 45 Val His Gly Arg Asp Lys Arg Leu Leu Val Ile Ile Gly Pro Cys Ser 50 55 60 Ile His Asp Pro Lys Ala Ala Leu Glu Tyr Ala Glu Arg Leu Leu Lys 65 70 75 80 Leu Arg Lys Gln Tyr Glu Asn Glu Leu Leu Ile Val Met Arg Val Tyr 85 90 95 Phe Glu Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp 100 105 110 Pro His Leu Asp Gly Thr Phe Asp Ile Asn Phe Gly Leu Arg Gln Ala 115 120 125 Arg Ser Leu Leu Leu Ser Leu Asn Asn Met Gly Met Pro Ala Ser Thr 130 135 140 Glu Phe Leu Asp Met Ile Thr Pro Gln Tyr Tyr Ala Asp Leu Ile Ser 145 150 155 160 Trp Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu 165 170 175 Leu Ala Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp 180 185 190 Gly Asn Leu Lys Ile Ala Ile Asp Ala Ile Gly Ala Ala Ser His Ser 195 200 205 His His Phe Leu Ser Val Thr Lys Ala Gly His Ser Ala Ile Val His 210 215 220 Thr Gly Gly Asn Pro Asp Cys His Val Ile Leu Arg Gly Gly Lys Glu 225 230 235 240 Pro Asn Tyr Asp Ala Gly His Val Ser Glu Ala Ala Glu Gln Leu Arg 245 250 255 Ala Ala Gly Val Thr Asp Lys Leu Met Ile Asp Cys Ser His Ala Asn 260 265 270 Ser Arg Lys Asp Tyr Thr Arg Gln Met Glu Val Ala Gln Asp Ile Ala 275 280 285 Ala Gln Leu Glu Gln Asp Gly Gly Asn Ile Met Gly Val Met Val Glu 290 295 300 Ser His Leu Val Glu Gly Arg Gln Asp Lys Pro Glu Val Tyr Gly Lys 305 310 315 320 Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Ala Thr Glu Glu Leu Leu 325 330 335 Ala Leu Leu Ala Gly Ala Asn Lys Lys Arg Met Ala Arg Ala 340 345 350 <210> 13 <211> 432 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(432) <400> 13 atg gca ttt ggt tcg atg aat tcc ggc gac gat tct ccg atg tcc gac 48 Met Ala Phe Gly Ser Met Asn Ser Gly Asp Asp Ser Pro Met Ser Asp 1 5 10 15 atc aac gtt acg ccg ttg gtg gac gtg atg ctg gtg ttg ctg att gtg 96 Ile Asn Val Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ile Val 20 25 30 ttt atg att act atg ccg gtg ctg acg cat tcc atc cct ttg gaa ctg 144 Phe Met Ile Thr Met Pro Val Leu Thr His Ser Ile Pro Leu Glu Leu 35 40 45 ccg acc gcg tcc gag cag aca aac aag cag gac aaa cag cct aaa gac 192 Pro Thr Ala Ser Glu Gln Thr Asn Lys Gln Asp Lys Gln Pro Lys Asp 50 55 60 ccc ctg cgc ctg acg att gat gcg aac ggc ggc tat tat gtc ggc ggg 240 Pro Leu Arg Leu Thr Ile Asp Ala Asn Gly Gly Tyr Tyr Val Gly Gly 65 70 75 80 gat tct gca agc aaa gtg gaa atc ggg gaa gtg gaa agc cgt ctg aaa 288 Asp Ser Ala Ser Lys Val Glu Ile Gly Glu Val Glu Ser Arg Leu Lys 85 90 95 gcc gcc aag gag cag aat gaa aac gtg att gtg gcg att gcg gca gac 336 Ala Ala Lys Glu Gln Asn Glu Asn Val Ile Val Ala Ile Ala Ala Asp 100 105 110 aag gcg gtg gaa tac gat tat gta aac aaa gct tta gaa gcc gcc cgt 384 Lys Ala Val Glu Tyr Asp Tyr Val Asn Lys Ala Leu Glu Ala Ala Arg 115 120 125 cag gca gga atc acc aaa atc ggt ttt gta acc gaa acc aag gcg caa 432 Gln Ala Gly Ile Thr Lys Ile Gly Phe Val Thr Glu Thr Lys Ala Gln 130 135 140 <210> 14 <211> 144 <212> PRT <213> Neisseria meningitidis <400> 14 Met Ala Phe Gly Ser Met Asn Ser Gly Asp Asp Ser Pro Met Ser Asp 1 5 10 15 Ile Asn Val Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ile Val 20 25 30 Phe Met Ile Thr Met Pro Val Leu Thr His Ser Ile Pro Leu Glu Leu 35 40 45 Pro Thr Ala Ser Glu Gln Thr Asn Lys Gln Asp Lys Gln Pro Lys Asp 50 55 60 Pro Leu Arg Leu Thr Ile Asp Ala Asn Gly Gly Tyr Tyr Val Gly Gly 65 70 75 80 Asp Ser Ala Ser Lys Val Glu Ile Gly Glu Val Glu Ser Arg Leu Lys 85 90 95 Ala Ala Lys Glu Gln Asn Glu Asn Val Ile Val Ala Ile Ala Ala Asp 100 105 110 Lys Ala Val Glu Tyr Asp Tyr Val Asn Lys Ala Leu Glu Ala Ala Arg 115 120 125 Gln Ala Gly Ile Thr Lys Ile Gly Phe Val Thr Glu Thr Lys Ala Gln 130 135 140 <210> 15 <211> 267 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(267) <400> 15 atg ctc aaa caa tcc atc gaa atc atc aac aaa ctc gga ctc cac gcc 48 Met Leu Lys Gln Ser Ile Glu Ile Ile Asn Lys Leu Gly Leu His Ala 1 5 10 15 cgc gcg tcc aac aag ttc acc caa acc gcg tcc caa ttc aaa agc gaa 96 Arg Ala Ser Asn Lys Phe Thr Gln Thr Ala Ser Gln Phe Lys Ser Glu 20 25 30 gtc tgg gtt acg aaa aac gac agc cgc gtc aac ggc aaa agc att atg 144 Val Trp Val Thr Lys Asn Asp Ser Arg Val Asn Gly Lys Ser Ile Met 35 40 45 ggg ctg atg atg ctc gcc gcc gcc aag ggt acg gtc atc gaa ctg gag 192 Gly Leu Met Met Leu Ala Ala Ala Lys Gly Thr Val Ile Glu Leu Glu 50 55 60 acg gac ggc gcg gac gag gcg gaa gcg atg cgc gcc ctg acc gac tta 240 Thr Asp Gly Ala Asp Glu Ala Glu Ala Met Arg Ala Leu Thr Asp Leu 65 70 75 80 atc aac ggc tac ttc ggc gag ggc gaa 267 Ile Asn Gly Tyr Phe Gly Glu Gly Glu 85 <210> 16 <211> 89 <212> PRT <213> Neisseria meningitidis <400> 16 Met Leu Lys Gln Ser Ile Glu Ile Ile Asn Lys Leu Gly Leu His Ala 1 5 10 15 Arg Ala Ser Asn Lys Phe Thr Gln Thr Ala Ser Gln Phe Lys Ser Glu 20 25 30 Val Trp Val Thr Lys Asn Asp Ser Arg Val Asn Gly Lys Ser Ile Met 35 40 45 Gly Leu Met Met Leu Ala Ala Ala Lys Gly Thr Val Ile Glu Leu Glu 50 55 60 Thr Asp Gly Ala Asp Glu Ala Glu Ala Met Arg Ala Leu Thr Asp Leu 65 70 75 80 Ile Asn Gly Tyr Phe Gly Glu Gly Glu 85 <210> 17 <211> 633 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(633) <400> 17 atg ccc atg aac ctt ttt caa aac gcc aaa ttc ttc acg acg gta aac 48 Met Pro Met Asn Leu Phe Gln Asn Ala Lys Phe Phe Thr Thr Val Asn 1 5 10 15 cat ctc aaa gac ctg ccg gac aca ccg ctc gaa att gcc ttt gtc ggc 96 His Leu Lys Asp Leu Pro Asp Thr Pro Leu Glu Ile Ala Phe Val Gly 20 25 30 agg agc aat gcc gga aaa tcc agt gcc atc aat acc ctg acc aac cat 144 Arg Ser Asn Ala Gly Lys Ser Ser Ala Ile Asn Thr Leu Thr Asn His 35 40 45 gtc cgt ctt gcc tac gtt tca aaa aca ccc gga cgg acg cag cat atc 192 Val Arg Leu Ala Tyr Val Ser Lys Thr Pro Gly Arg Thr Gln His Ile 50 55 60 aac ttc ttc gag ctg cag aac ggc aat ttt atg gtc gat ttg ccc ggc 240 Asn Phe Phe Glu Leu Gln Asn Gly Asn Phe Met Val Asp Leu Pro Gly 65 70 75 80 tac ggt tat gcc caa gtc ccc gaa gca gta cgc gca cat tgg gtc aat 288 Tyr Gly Tyr Ala Gln Val Pro Glu Ala Val Arg Ala His Trp Val Asn 85 90 95 ctg ctc ggc gac tat ctg caa cag cgc aaa cag ctt atc ggg ctg gtt 336 Leu Leu Gly Asp Tyr Leu Gln Gln Arg Lys Gln Leu Ile Gly Leu Val 100 105 110 ttg att atg gat gcc cgc cat cct tta aaa gaa ctc gac atc cgt atg 384 Leu Ile Met Asp Ala Arg His Pro Leu Lys Glu Leu Asp Ile Arg Met 115 120 125 ctg gac ttt ttc cac acg acc ggc aga ccg gtt cac atc ctg ctg tca 432 Leu Asp Phe Phe His Thr Thr Gly Arg Pro Val His Ile Leu Leu Ser 130 135 140 aaa gcc gac aaa tta tcc aaa aac gaa cag ata aaa acc ctg tcc caa 480 Lys Ala Asp Lys Leu Ser Lys Asn Glu Gln Ile Lys Thr Leu Ser Gln 145 150 155 160 gtc aaa aaa ctg ctc aaa cct tat tcc gac agg caa aac atc agc gta 528 Val Lys Lys Leu Leu Lys Pro Tyr Ser Asp Arg Gln Asn Ile Ser Val 165 170 175 cag ctg ttt tcc agc ctg aaa aaa caa ggt att gac gag gcc aac cga 576 Gln Leu Phe Ser Ser Leu Lys Lys Gln Gly Ile Asp Glu Ala Asn Arg 180 185 190 act gtc gga agc tgg ttt gac gca gca gat gcc gcc gct tcc tct cca 624 Thr Val Gly Ser Trp Phe Asp Ala Ala Asp Ala Ala Ala Ser Ser Pro 195 200 205 aag gaa aac 633 Lys Glu Asn 210 <210> 18 <211> 211 <212> PRT <213> Neisseria meningitidis <400> 18 Met Pro Met Asn Leu Phe Gln Asn Ala Lys Phe Phe Thr Thr Val Asn 1 5 10 15 His Leu Lys Asp Leu Pro Asp Thr Pro Leu Glu Ile Ala Phe Val Gly 20 25 30 Arg Ser Asn Ala Gly Lys Ser Ser Ala Ile Asn Thr Leu Thr Asn His 35 40 45 Val Arg Leu Ala Tyr Val Ser Lys Thr Pro Gly Arg Thr Gln His Ile 50 55 60 Asn Phe Phe Glu Leu Gln Asn Gly Asn Phe Met Val Asp Leu Pro Gly 65 70 75 80 Tyr Gly Tyr Ala Gln Val Pro Glu Ala Val Arg Ala His Trp Val Asn 85 90 95 Leu Leu Gly Asp Tyr Leu Gln Gln Arg Lys Gln Leu Ile Gly Leu Val 100 105 110 Leu Ile Met Asp Ala Arg His Pro Leu Lys Glu Leu Asp Ile Arg Met 115 120 125 Leu Asp Phe Phe His Thr Thr Gly Arg Pro Val His Ile Leu Leu Ser 130 135 140 Lys Ala Asp Lys Leu Ser Lys Asn Glu Gln Ile Lys Thr Leu Ser Gln 145 150 155 160 Val Lys Lys Leu Leu Lys Pro Tyr Ser Asp Arg Gln Asn Ile Ser Val 165 170 175 Gln Leu Phe Ser Ser Leu Lys Lys Gln Gly Ile Asp Glu Ala Asn Arg 180 185 190 Thr Val Gly Ser Trp Phe Asp Ala Ala Asp Ala Ala Ala Ser Ser Pro 195 200 205 Lys Glu Asn 210 <210> 19 <211> 621 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(621) <400> 19 atg aaa cga ttg act tta ttg gcc ttt gtt ttg gct gcc ggt gcg gtt 48 Met Lys Arg Leu Thr Leu Leu Ala Phe Val Leu Ala Ala Gly Ala Val 1 5 10 15 tcc gca tct ccc aaa gca gac gtg gaa aaa ggc aaa cag gtt gcc gca 96 Ser Ala Ser Pro Lys Ala Asp Val Glu Lys Gly Lys Gln Val Ala Ala 20 25 30 acg gtt tgt gcg gct tgc cat gca gca gac ggt aac agc ggc att gcg 144 Thr Val Cys Ala Ala Cys His Ala Ala Asp Gly Asn Ser Gly Ile Ala 35 40 45 atg tat ccg cgt ttg gcg gca cag cat act gct tac atc tat cat caa 192 Met Tyr Pro Arg Leu Ala Ala Gln His Thr Ala Tyr Ile Tyr His Gln 50 55 60 acc atc ggc atc cgc gac ggt aaa cgc acc cac ggt tcg gca gct gtg 240 Thr Ile Gly Ile Arg Asp Gly Lys Arg Thr His Gly Ser Ala Ala Val 65 70 75 80 atg aaa ccg gtg gta atg aat ttg agc gat cag gat att ttg aac gta 288 Met Lys Pro Val Val Met Asn Leu Ser Asp Gln Asp Ile Leu Asn Val 85 90 95 tcc gca ttc tat gcc aaa cag cag ccc aaa tcc ggt gaa gcc aat cct 336 Ser Ala Phe Tyr Ala Lys Gln Gln Pro Lys Ser Gly Glu Ala Asn Pro 100 105 110 aag gaa aat ccc gaa ttg ggt gcg aaa atc tat cgc ggc ggt ttg agc 384 Lys Glu Asn Pro Glu Leu Gly Ala Lys Ile Tyr Arg Gly Gly Leu Ser 115 120 125 gat aaa aaa gtg ccg gcg tgt atg tcc tgc cac ggt ccg agc ggt gcg 432 Asp Lys Lys Val Pro Ala Cys Met Ser Cys His Gly Pro Ser Gly Ala 130 135 140 ggt atg ccg ggg ggc gga agc gaa att cag gct tat ccg cgt ttg ggc 480 Gly Met Pro Gly Gly Gly Ser Glu Ile Gln Ala Tyr Pro Arg Leu Gly 145 150 155 160 ggt cag cat cag gca tat att gtt gaa cag atg aat gcc tac aag tcc 528 Gly Gln His Gln Ala Tyr Ile Val Glu Gln Met Asn Ala Tyr Lys Ser 165 170 175 ggt cag cgt aaa aat acc atc atg gaa gat att gca aac cgt atg tct 576 Gly Gln Arg Lys Asn Thr Ile Met Glu Asp Ile Ala Asn Arg Met Ser 180 185 190 gaa gaa gat ttg aaa gcg gtc gcc aac ttt atc caa ggt ttg cgt 621 Glu Glu Asp Leu Lys Ala Val Ala Asn Phe Ile Gln Gly Leu Arg 195 200 205 <210> 20 <211> 207 <212> PRT <213> Neisseria meningitidis <400> 20 Met Lys Arg Leu Thr Leu Leu Ala Phe Val Leu Ala Ala Gly Ala Val 1 5 10 15 Ser Ala Ser Pro Lys Ala Asp Val Glu Lys Gly Lys Gln Val Ala Ala 20 25 30 Thr Val Cys Ala Ala Cys His Ala Ala Asp Gly Asn Ser Gly Ile Ala 35 40 45 Met Tyr Pro Arg Leu Ala Ala Gln His Thr Ala Tyr Ile Tyr His Gln 50 55 60 Thr Ile Gly Ile Arg Asp Gly Lys Arg Thr His Gly Ser Ala Ala Val 65 70 75 80 Met Lys Pro Val Val Met Asn Leu Ser Asp Gln Asp Ile Leu Asn Val 85 90 95 Ser Ala Phe Tyr Ala Lys Gln Gln Pro Lys Ser Gly Glu Ala Asn Pro 100 105 110 Lys Glu Asn Pro Glu Leu Gly Ala Lys Ile Tyr Arg Gly Gly Leu Ser 115 120 125 Asp Lys Lys Val Pro Ala Cys Met Ser Cys His Gly Pro Ser Gly Ala 130 135 140 Gly Met Pro Gly Gly Gly Ser Glu Ile Gln Ala Tyr Pro Arg Leu Gly 145 150 155 160 Gly Gln His Gln Ala Tyr Ile Val Glu Gln Met Asn Ala Tyr Lys Ser 165 170 175 Gly Gln Arg Lys Asn Thr Ile Met Glu Asp Ile Ala Asn Arg Met Ser 180 185 190 Glu Glu Asp Leu Lys Ala Val Ala Asn Phe Ile Gln Gly Leu Arg 195 200 205 <210> 21 <211> 765 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(765) <400> 21 atg ccg tct gaa gcc cga ttt ttc agg ctt cag acg gca ttt ccc cgt 48 Met Pro Ser Glu Ala Arg Phe Phe Arg Leu Gln Thr Ala Phe Pro Arg 1 5 10 15 ttg att tgc ggt ata atc cgc ctt tac cca ttg ttt gca aag cac aat 96 Leu Ile Cys Gly Ile Ile Arg Leu Tyr Pro Leu Phe Ala Lys His Asn 20 25 30 atg aca cgc aaa atc ctc gtt acc tcc gcc ctg ccc tat gcc aac ggc 144 Met Thr Arg Lys Ile Leu Val Thr Ser Ala Leu Pro Tyr Ala Asn Gly 35 40 45 agc atc cac ctc ggc cac atg gtc gaa cac atc caa acc gac gtt tgg 192 Ser Ile His Leu Gly His Met Val Glu His Ile Gln Thr Asp Val Trp 50 55 60 gtg cgc ttt caa aaa ctg cgc ggc aac gaa tgc cac tac tgc tgc gcc 240 Val Arg Phe Gln Lys Leu Arg Gly Asn Glu Cys His Tyr Cys Cys Ala 65 70 75 80 gac gac acc cac ggc acg ccc gtg atg ctt gcc gcg caa aaa caa ggc 288 Asp Asp Thr His Gly Thr Pro Val Met Leu Ala Ala Gln Lys Gln Gly 85 90 95 atc gcg ccc gaa gac atg att gcc aaa gtg cgc gaa gag cac ctc gcc 336 Ile Ala Pro Glu Asp Met Ile Ala Lys Val Arg Glu Glu His Leu Ala 100 105 110 gac ttt act ggc ttt ttc atc ggt tac gac aat tat tac agc acc cat 384 Asp Phe Thr Gly Phe Phe Ile Gly Tyr Asp Asn Tyr Tyr Ser Thr His 115 120 125 tcc cct gaa aac aaa cag ttt tcc caa gac att tac cgc gcg ctg aaa 432 Ser Pro Glu Asn Lys Gln Phe Ser Gln Asp Ile Tyr Arg Ala Leu Lys 130 135 140 gcc aac ggc aag att gag agc cgc gtc atc gag cag ctt ttc gac ccc 480 Ala Asn Gly Lys Ile Glu Ser Arg Val Ile Glu Gln Leu Phe Asp Pro 145 150 155 160 gaa aaa caa atg ttc ctg ccc gac cgc ttc gtt aaa ggc gaa tgc ccg 528 Glu Lys Gln Met Phe Leu Pro Asp Arg Phe Val Lys Gly Glu Cys Pro 165 170 175 aaa tgc cac gcc caa gac caa tac ggc gac aac tgc gaa gtc tgc ggc 576 Lys Cys His Ala Gln Asp Gln Tyr Gly Asp Asn Cys Glu Val Cys Gly 180 185 190 acg acc tat tcc ccg acc gaa ctg att aac ccg tat tcc gcc gtt tcc 624 Thr Thr Tyr Ser Pro Thr Glu Leu Ile Asn Pro Tyr Ser Ala Val Ser 195 200 205 ggc gcg aaa ccc gaa ttg cgc gaa tcc gaa cac ttc ttc ttc aaa ctg 672 Gly Ala Lys Pro Glu Leu Arg Glu Ser Glu His Phe Phe Phe Lys Leu 210 215 220 gga gaa tgc gcc gac ttc ctc aaa gca tgg act tcc ggc aac aac ccg 720 Gly Glu Cys Ala Asp Phe Leu Lys Ala Trp Thr Ser Gly Asn Asn Pro 225 230 235 240 cac gac ggc aag ccc cat ctg caa gcc gaa gcc ctc aac aaa atg 765 His Asp Gly Lys Pro His Leu Gln Ala Glu Ala Leu Asn Lys Met 245 250 255 <210> 22 <211> 255 <212> PRT <213> Neisseria meningitidis <400> 22 Met Pro Ser Glu Ala Arg Phe Phe Arg Leu Gln Thr Ala Phe Pro Arg 1 5 10 15 Leu Ile Cys Gly Ile Ile Arg Leu Tyr Pro Leu Phe Ala Lys His Asn 20 25 30 Met Thr Arg Lys Ile Leu Val Thr Ser Ala Leu Pro Tyr Ala Asn Gly 35 40 45 Ser Ile His Leu Gly His Met Val Glu His Ile Gln Thr Asp Val Trp 50 55 60 Val Arg Phe Gln Lys Leu Arg Gly Asn Glu Cys His Tyr Cys Cys Ala 65 70 75 80 Asp Asp Thr His Gly Thr Pro Val Met Leu Ala Ala Gln Lys Gln Gly 85 90 95 Ile Ala Pro Glu Asp Met Ile Ala Lys Val Arg Glu Glu His Leu Ala 100 105 110 Asp Phe Thr Gly Phe Phe Ile Gly Tyr Asp Asn Tyr Tyr Ser Thr His 115 120 125 Ser Pro Glu Asn Lys Gln Phe Ser Gln Asp Ile Tyr Arg Ala Leu Lys 130 135 140 Ala Asn Gly Lys Ile Glu Ser Arg Val Ile Glu Gln Leu Phe Asp Pro 145 150 155 160 Glu Lys Gln Met Phe Leu Pro Asp Arg Phe Val Lys Gly Glu Cys Pro 165 170 175 Lys Cys His Ala Gln Asp Gln Tyr Gly Asp Asn Cys Glu Val Cys Gly 180 185 190 Thr Thr Tyr Ser Pro Thr Glu Leu Ile Asn Pro Tyr Ser Ala Val Ser 195 200 205 Gly Ala Lys Pro Glu Leu Arg Glu Ser Glu His Phe Phe Phe Lys Leu 210 215 220 Gly Glu Cys Ala Asp Phe Leu Lys Ala Trp Thr Ser Gly Asn Asn Pro 225 230 235 240 His Asp Gly Lys Pro His Leu Gln Ala Glu Ala Leu Asn Lys Met 245 250 255 <210> 23 <211> 1539 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1539) <400> 23 atg aag ttt tta gac cgt gag gca agc att gcc aag ccg ggt ttc aac 48 Met Lys Phe Leu Asp Arg Glu Ala Ser Ile Ala Lys Pro Gly Phe Asn 1 5 10 15 cgt tgg ctc gta ccg ccc gca gca ttg gcg gta cac ctt gcc atc ggg 96 Arg Trp Leu Val Pro Pro Ala Ala Leu Ala Val His Leu Ala Ile Gly 20 25 30 cag att tac gcc tat tcc gta ttc aac gcg ccg ctg acc aaa ctt atc 144 Gln Ile Tyr Ala Tyr Ser Val Phe Asn Ala Pro Leu Thr Lys Leu Ile 35 40 45 ggc ata acc gaa tcg gcg gcc gga gat tgg aag ctg acg acc gta ggt 192 Gly Ile Thr Glu Ser Ala Ala Gly Asp Trp Lys Leu Thr Thr Val Gly 50 55 60 tgg att ttc agt atc gca ctc gcg atg ctg ggc gcg tcg gcc gcc ctg 240 Trp Ile Phe Ser Ile Ala Leu Ala Met Leu Gly Ala Ser Ala Ala Leu 65 70 75 80 ttc ggt acg tgg atg gaa cgg gta ggg ccg cgc aaa gcc ata ttt gcc 288 Phe Gly Thr Trp Met Glu Arg Val Gly Pro Arg Lys Ala Ile Phe Ala 85 90 95 gcc gcc tgc tgt ttc agc ctg ggc ttc ttc gta tcc gca ttc ggc gtg 336 Ala Ala Cys Cys Phe Ser Leu Gly Phe Phe Val Ser Ala Phe Gly Val 100 105 110 cgt acg cac aac ctc ttc ctg ctc tat ttg ggc aac ggc gtc atc ggc 384 Arg Thr His Asn Leu Phe Leu Leu Tyr Leu Gly Asn Gly Val Ile Gly 115 120 125 ggc gta ggc ttg ggt ttg ggc tac atc ggg ccg gtt tcc aca ctg atg 432 Gly Val Gly Leu Gly Leu Gly Tyr Ile Gly Pro Val Ser Thr Leu Met 130 135 140 aaa tgg ttt ccc gac aag ccg ggt atg gcg acc ggt ttg gcg att atg 480 Lys Trp Phe Pro Asp Lys Pro Gly Met Ala Thr Gly Leu Ala Ile Met 145 150 155 160 ggt ttc ggt ggc ggc gca atg ctg gcc tcg ccg ctt tcc gta tca ctg 528 Gly Phe Gly Gly Gly Ala Met Leu Ala Ser Pro Leu Ser Val Ser Leu 165 170 175 atg aac acc ttt tca aac gct act tcg gtt ggg gtt gcc gaa acc ttc 576 Met Asn Thr Phe Ser Asn Ala Thr Ser Val Gly Val Ala Glu Thr Phe 180 185 190 gcc gta ttg ggt ctg ctt tac ctc gca ctg atg atg ttc ggc gcg ttt 624 Ala Val Leu Gly Leu Leu Tyr Leu Ala Leu Met Met Phe Gly Ala Phe 195 200 205 acc atc cgc gta cct gcc gac ggc tgg aaa cct gaa ggc tat acc gcg 672 Thr Ile Arg Val Pro Ala Asp Gly Trp Lys Pro Glu Gly Tyr Thr Ala 210 215 220 ccg aaa acg caa aac aag ctg gtc agc agc aat cat gtc aac gtg tcc 720 Pro Lys Thr Gln Asn Lys Leu Val Ser Ser Asn His Val Asn Val Ser 225 230 235 240 caa gcc atg aaa acg ccg cag ttt tgg ctg ttg ttc tgg gta ttg tgc 768 Gln Ala Met Lys Thr Pro Gln Phe Trp Leu Leu Phe Trp Val Leu Cys 245 250 255 ctg aac gta act gcc ggc atc ggc gta ttg ggt cag gca tcc gtg atg 816 Leu Asn Val Thr Ala Gly Ile Gly Val Leu Gly Gln Ala Ser Val Met 260 265 270 att cag gaa ctc ttt tcc gaa acc tcc ata ggc agg cag gcg gca gtc 864 Ile Gln Glu Leu Phe Ser Glu Thr Ser Ile Gly Arg Gln Ala Ala Val 275 280 285 ggc gca ggt gcg gcg gca ggc ttc gtc agc ctc ctg agc ctg ttt aac 912 Gly Ala Gly Ala Ala Ala Gly Phe Val Ser Leu Leu Ser Leu Phe Asn 290 295 300 atg ggc gga cgc ttt ttg tgg tcg agc gtt tcc gac aaa atc gga cgc 960 Met Gly Gly Arg Phe Leu Trp Ser Ser Val Ser Asp Lys Ile Gly Arg 305 310 315 320 aaa aac acc tac acc atc ttc ttc gta ctc ggt tcg ctg ctg tat ttc 1008 Lys Asn Thr Tyr Thr Ile Phe Phe Val Leu Gly Ser Leu Leu Tyr Phe 325 330 335 gcc gtt ccc tcc atc ggc gag ggc ggc agc aaa gcc ctg ttc atc atc 1056 Ala Val Pro Ser Ile Gly Glu Gly Gly Ser Lys Ala Leu Phe Ile Ile 340 345 350 ggc ttt tgc gtg att att tcc atg tac ggc ggc gga ttt gcc gcc att 1104 Gly Phe Cys Val Ile Ile Ser Met Tyr Gly Gly Gly Phe Ala Ala Ile 355 360 365 ccc gcc tac ctg aaa gac ctg ttc ggc acc tat cag gtc ggc gcg att 1152 Pro Ala Tyr Leu Lys Asp Leu Phe Gly Thr Tyr Gln Val Gly Ala Ile 370 375 380 cac gga cgc atc ctg ctg gcc tgg tca acc gcc gcc gtc atc ggc ccg 1200 His Gly Arg Ile Leu Leu Ala Trp Ser Thr Ala Ala Val Ile Gly Pro 385 390 395 400 gta ctg gtc aat tac ata cgc caa agc caa atc gac agc ggc ata ccg 1248 Val Leu Val Asn Tyr Ile Arg Gln Ser Gln Ile Asp Ser Gly Ile Pro 405 410 415 gcg gca cag gca tac agc gta acc atg tac atc atg gcg ggt ctg ctg 1296 Ala Ala Gln Ala Tyr Ser Val Thr Met Tyr Ile Met Ala Gly Leu Leu 420 425 430 att atc ggt ttg ttg tgc aac ctc gcc gtc aaa tcc gta cac gaa aaa 1344 Ile Ile Gly Leu Leu Cys Asn Leu Ala Val Lys Ser Val His Glu Lys 435 440 445 cac cac gaa aaa gac atc aaa acc gcc gca cac agc ggc aac ccc gat 1392 His His Glu Lys Asp Ile Lys Thr Ala Ala His Ser Gly Asn Pro Asp 450 455 460 gac gaa acc gcc ata tcc gac gct tac ctt gtg ggc gaa aaa gtt tcc 1440 Asp Glu Thr Ala Ile Ser Asp Ala Tyr Leu Val Gly Glu Lys Val Ser 465 470 475 480 ggc ggc ggc ata tcg gtc tgg tgg cgt tgg gca ttg gcc gtc ata ccg 1488 Gly Gly Gly Ile Ser Val Trp Trp Arg Trp Ala Leu Ala Val Ile Pro 485 490 495 ctc gcc tac ggc gtg gtg atg atc ttt gtc aaa gca ctc gac ctt ttc 1536 Leu Ala Tyr Gly Val Val Met Ile Phe Val Lys Ala Leu Asp Leu Phe 500 505 510 tcc 1539 Ser <210> 24 <211> 513 <212> PRT <213> Neisseria meningitidis <400> 24 Met Lys Phe Leu Asp Arg Glu Ala Ser Ile Ala Lys Pro Gly Phe Asn 1 5 10 15 Arg Trp Leu Val Pro Pro Ala Ala Leu Ala Val His Leu Ala Ile Gly 20 25 30 Gln Ile Tyr Ala Tyr Ser Val Phe Asn Ala Pro Leu Thr Lys Leu Ile 35 40 45 Gly Ile Thr Glu Ser Ala Ala Gly Asp Trp Lys Leu Thr Thr Val Gly 50 55 60 Trp Ile Phe Ser Ile Ala Leu Ala Met Leu Gly Ala Ser Ala Ala Leu 65 70 75 80 Phe Gly Thr Trp Met Glu Arg Val Gly Pro Arg Lys Ala Ile Phe Ala 85 90 95 Ala Ala Cys Cys Phe Ser Leu Gly Phe Phe Val Ser Ala Phe Gly Val 100 105 110 Arg Thr His Asn Leu Phe Leu Leu Tyr Leu Gly Asn Gly Val Ile Gly 115 120 125 Gly Val Gly Leu Gly Leu Gly Tyr Ile Gly Pro Val Ser Thr Leu Met 130 135 140 Lys Trp Phe Pro Asp Lys Pro Gly Met Ala Thr Gly Leu Ala Ile Met 145 150 155 160 Gly Phe Gly Gly Gly Ala Met Leu Ala Ser Pro Leu Ser Val Ser Leu 165 170 175 Met Asn Thr Phe Ser Asn Ala Thr Ser Val Gly Val Ala Glu Thr Phe 180 185 190 Ala Val Leu Gly Leu Leu Tyr Leu Ala Leu Met Met Phe Gly Ala Phe 195 200 205 Thr Ile Arg Val Pro Ala Asp Gly Trp Lys Pro Glu Gly Tyr Thr Ala 210 215 220 Pro Lys Thr Gln Asn Lys Leu Val Ser Ser Asn His Val Asn Val Ser 225 230 235 240 Gln Ala Met Lys Thr Pro Gln Phe Trp Leu Leu Phe Trp Val Leu Cys 245 250 255 Leu Asn Val Thr Ala Gly Ile Gly Val Leu Gly Gln Ala Ser Val Met 260 265 270 Ile Gln Glu Leu Phe Ser Glu Thr Ser Ile Gly Arg Gln Ala Ala Val 275 280 285 Gly Ala Gly Ala Ala Ala Gly Phe Val Ser Leu Leu Ser Leu Phe Asn 290 295 300 Met Gly Gly Arg Phe Leu Trp Ser Ser Val Ser Asp Lys Ile Gly Arg 305 310 315 320 Lys Asn Thr Tyr Thr Ile Phe Phe Val Leu Gly Ser Leu Leu Tyr Phe 325 330 335 Ala Val Pro Ser Ile Gly Glu Gly Gly Ser Lys Ala Leu Phe Ile Ile 340 345 350 Gly Phe Cys Val Ile Ile Ser Met Tyr Gly Gly Gly Phe Ala Ala Ile 355 360 365 Pro Ala Tyr Leu Lys Asp Leu Phe Gly Thr Tyr Gln Val Gly Ala Ile 370 375 380 His Gly Arg Ile Leu Leu Ala Trp Ser Thr Ala Ala Val Ile Gly Pro 385 390 395 400 Val Leu Val Asn Tyr Ile Arg Gln Ser Gln Ile Asp Ser Gly Ile Pro 405 410 415 Ala Ala Gln Ala Tyr Ser Val Thr Met Tyr Ile Met Ala Gly Leu Leu 420 425 430 Ile Ile Gly Leu Leu Cys Asn Leu Ala Val Lys Ser Val His Glu Lys 435 440 445 His His Glu Lys Asp Ile Lys Thr Ala Ala His Ser Gly Asn Pro Asp 450 455 460 Asp Glu Thr Ala Ile Ser Asp Ala Tyr Leu Val Gly Glu Lys Val Ser 465 470 475 480 Gly Gly Gly Ile Ser Val Trp Trp Arg Trp Ala Leu Ala Val Ile Pro 485 490 495 Leu Ala Tyr Gly Val Val Met Ile Phe Val Lys Ala Leu Asp Leu Phe 500 505 510 Ser <210> 25 <211> 1038 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1038) <400> 25 ttg cag cct tta gtc agc gta ttg att tgc gcc tac aac gta gaa aaa 48 Leu Gln Pro Leu Val Ser Val Leu Ile Cys Ala Tyr Asn Val Glu Lys 1 5 10 15 tat ttc gcc caa tca tta gcc acc gtc gtg aat cag act tgg cgc aac 96 Tyr Phe Ala Gln Ser Leu Ala Thr Val Val Asn Gln Thr Trp Arg Asn 20 25 30 ttg gag att ttg att gtc gat gac ggc tcg aca gac ggt acg ctt gcc 144 Leu Glu Ile Leu Ile Val Asp Asp Gly Ser Thr Asp Gly Thr Leu Ala 35 40 45 att gcc aag gat ttt caa aag cgg gac agc cgt atc aaa atc ctt gca 192 Ile Ala Lys Asp Phe Gln Lys Arg Asp Ser Arg Ile Lys Ile Leu Ala 50 55 60 caa gct caa aat tcc ggc ctg att ccc tct tta aac atc ggg ctg gac 240 Gln Ala Gln Asn Ser Gly Leu Ile Pro Ser Leu Asn Ile Gly Leu Asp 65 70 75 80 gaa ttg gca aag tca gga atg ggg gaa tat att gca cgc acc gat gcc 288 Glu Leu Ala Lys Ser Gly Met Gly Glu Tyr Ile Ala Arg Thr Asp Ala 85 90 95 gac gat att gcc gcc ccc gac tgg att gag aaa atc gtg ggc gag atg 336 Asp Asp Ile Ala Ala Pro Asp Trp Ile Glu Lys Ile Val Gly Glu Met 100 105 110 gaa aaa gac cgc agc atc atc gcg atg ggc gcg tgg ctg gaa gtt ttg 384 Glu Lys Asp Arg Ser Ile Ile Ala Met Gly Ala Trp Leu Glu Val Leu 115 120 125 tcg gaa gaa aag gac ggc aac cgg ctg gcg cgg cat cac agg cac ggc 432 Ser Glu Glu Lys Asp Gly Asn Arg Leu Ala Arg His His Arg His Gly 130 135 140 aaa att tgg aaa aag ccg acc cgg cac gaa gat att gcc gac ttt ttc 480 Lys Ile Trp Lys Lys Pro Thr Arg His Glu Asp Ile Ala Asp Phe Phe 145 150 155 160 cct ttc ggc aac ccc ata cac aac aac acg atg att atg cgg cgc agc 528 Pro Phe Gly Asn Pro Ile His Asn Asn Thr Met Ile Met Arg Arg Ser 165 170 175 gtc att gac ggc gga ttg cgt tac aac acc gag cgg gat tgg gcg gaa 576 Val Ile Asp Gly Gly Leu Arg Tyr Asn Thr Glu Arg Asp Trp Ala Glu 180 185 190 gat tac caa ttt tgg tac gat gtc agc aaa ttg ggc agg ctg gct tat 624 Asp Tyr Gln Phe Trp Tyr Asp Val Ser Lys Leu Gly Arg Leu Ala Tyr 195 200 205 tat ccc gaa gcc ttg gtc aaa tac cgc ctt cac gcc aat cag gtt tca 672 Tyr Pro Glu Ala Leu Val Lys Tyr Arg Leu His Ala Asn Gln Val Ser 210 215 220 tcc aaa tac agc atc cgc caa cac gaa atc gcg caa ggc atc caa aaa 720 Ser Lys Tyr Ser Ile Arg Gln His Glu Ile Ala Gln Gly Ile Gln Lys 225 230 235 240 acc gcc aga aac gat ttt ttg cag tct atg ggt ttt aaa acc cgg ttc 768 Thr Ala Arg Asn Asp Phe Leu Gln Ser Met Gly Phe Lys Thr Arg Phe 245 250 255 gac agc ctt gaa tac cgc caa ata aaa gca gta gcg tat gaa ttg ctg 816 Asp Ser Leu Glu Tyr Arg Gln Ile Lys Ala Val Ala Tyr Glu Leu Leu 260 265 270 gag aaa cat ttg ccg gaa gaa gat ttt gaa cgc gcc cgc cgg ttt ttg 864 Glu Lys His Leu Pro Glu Glu Asp Phe Glu Arg Ala Arg Arg Phe Leu 275 280 285 tac caa tgc ttc aaa cgg acg gac acg ccg ccc gcc ggc gcg tgg ctg 912 Tyr Gln Cys Phe Lys Arg Thr Asp Thr Pro Pro Ala Gly Ala Trp Leu 290 295 300 gat ttc gcg gca gac ggc aag atg agg cgg ctg ttt acc atg agg caa 960 Asp Phe Ala Ala Asp Gly Lys Met Arg Arg Leu Phe Thr Met Arg Gln 305 310 315 320 tac ttc ggc att ttg cac cgg ctg att aaa aac cgc cgg cag gcg cgg 1008 Tyr Phe Gly Ile Leu His Arg Leu Ile Lys Asn Arg Arg Gln Ala Arg 325 330 335 tcg gat tcg gca ggg aaa gaa cag gag att 1038 Ser Asp Ser Ala Gly Lys Glu Gln Glu Ile 340 345 <210> 26 <211> 346 <212> PRT <213> Neisseria meningitidis <400> 26 Leu Gln Pro Leu Val Ser Val Leu Ile Cys Ala Tyr Asn Val Glu Lys 1 5 10 15 Tyr Phe Ala Gln Ser Leu Ala Thr Val Val Asn Gln Thr Trp Arg Asn 20 25 30 Leu Glu Ile Leu Ile Val Asp Asp Gly Ser Thr Asp Gly Thr Leu Ala 35 40 45 Ile Ala Lys Asp Phe Gln Lys Arg Asp Ser Arg Ile Lys Ile Leu Ala 50 55 60 Gln Ala Gln Asn Ser Gly Leu Ile Pro Ser Leu Asn Ile Gly Leu Asp 65 70 75 80 Glu Leu Ala Lys Ser Gly Met Gly Glu Tyr Ile Ala Arg Thr Asp Ala 85 90 95 Asp Asp Ile Ala Ala Pro Asp Trp Ile Glu Lys Ile Val Gly Glu Met 100 105 110 Glu Lys Asp Arg Ser Ile Ile Ala Met Gly Ala Trp Leu Glu Val Leu 115 120 125 Ser Glu Glu Lys Asp Gly Asn Arg Leu Ala Arg His His Arg His Gly 130 135 140 Lys Ile Trp Lys Lys Pro Thr Arg His Glu Asp Ile Ala Asp Phe Phe 145 150 155 160 Pro Phe Gly Asn Pro Ile His Asn Asn Thr Met Ile Met Arg Arg Ser 165 170 175 Val Ile Asp Gly Gly Leu Arg Tyr Asn Thr Glu Arg Asp Trp Ala Glu 180 185 190 Asp Tyr Gln Phe Trp Tyr Asp Val Ser Lys Leu Gly Arg Leu Ala Tyr 195 200 205 Tyr Pro Glu Ala Leu Val Lys Tyr Arg Leu His Ala Asn Gln Val Ser 210 215 220 Ser Lys Tyr Ser Ile Arg Gln His Glu Ile Ala Gln Gly Ile Gln Lys 225 230 235 240 Thr Ala Arg Asn Asp Phe Leu Gln Ser Met Gly Phe Lys Thr Arg Phe 245 250 255 Asp Ser Leu Glu Tyr Arg Gln Ile Lys Ala Val Ala Tyr Glu Leu Leu 260 265 270 Glu Lys His Leu Pro Glu Glu Asp Phe Glu Arg Ala Arg Arg Phe Leu 275 280 285 Tyr Gln Cys Phe Lys Arg Thr Asp Thr Pro Pro Ala Gly Ala Trp Leu 290 295 300 Asp Phe Ala Ala Asp Gly Lys Met Arg Arg Leu Phe Thr Met Arg Gln 305 310 315 320 Tyr Phe Gly Ile Leu His Arg Leu Ile Lys Asn Arg Arg Gln Ala Arg 325 330 335 Ser Asp Ser Ala Gly Lys Glu Gln Glu Ile 340 345 <210> 27 <211> 1856 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1857) <400> 27 atg cca gaa tac cgc tcc aaa acc tcc acc cac ggt cgc aat atg gcg 48 Met Pro Glu Tyr Arg Ser Lys Thr Ser Thr His Gly Arg Asn Met Ala 1 5 10 15 ggc gcg cgc gcg ttg tgg cgc gcc acc ggc gtg atg gaa acc gac ttc 96 Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Val Met Glu Thr Asp Phe 20 25 30 ggc aaa ccg att atc gcc gtt gcc aac tcg ttc acc caa ttc gtg cca 144 Gly Lys Pro Ile Ile Ala Val Ala Asn Ser Phe Thr Gln Phe Val Pro 35 40 45 ggt cat gtc cac ctg cac aat atg ggc cag ctg gtt gcc cgc gaa atc 192 Gly His Val His Leu His Asn Met Gly Gln Leu Val Ala Arg Glu Ile 50 55 60 gaa aaa gcc ggc gcc atc gcc aaa gaa ttc aac acc atc gcc atc gac 240 Glu Lys Ala Gly Ala Ile Ala Lys Glu Phe Asn Thr Ile Ala Ile Asp 65 70 75 80 gac ggc atc gct atg gga cac agc ggt atg ctg tat tcc ctg ccc agc 288 Asp Gly Ile Ala Met Gly His Ser Gly Met Leu Tyr Ser Leu Pro Ser 85 90 95 cgc gat ttg att gcc gac tcc atc gaa tat atg gtc aat gcc cac tgc 336 Arg Asp Leu Ile Ala Asp Ser Ile Glu Tyr Met Val Asn Ala His Cys 100 105 110 gcc gac gcg ctg gtg tgc att tcc aac tgc gac aaa atc acc ccg ggc 384 Ala Asp Ala Leu Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 115 120 125 atg ctg att gcc gcg atg cgc ctg aac atc ccg acc atc ttc gtt tcc 432 Met Leu Ile Ala Ala Met Arg Leu Asn Ile Pro Thr Ile Phe Val Ser 130 135 140 ggc ggt ccg atg gaa gca ggt aaa gtt atc ggc gtg gca aac atc cag 480 Gly Gly Pro Met Glu Ala Gly Lys Val Ile Gly Val Ala Asn Ile Gln 145 150 155 160 ccc gaa cgc cgt ttg gac ttg att gac gcg atg att gaa tcg gcg gac 528 Pro Glu Arg Arg Leu Asp Leu Ile Asp Ala Met Ile Glu Ser Ala Asp 165 170 175 gac aat atc agc aac cgg caa gtt gaa gaa gtc gaa caa aac gcc tgc 576 Asp Asn Ile Ser Asn Arg Gln Val Glu Glu Val Glu Gln Asn Ala Cys 180 185 190 ccg acc tgc ggc tcg tgt tcg ggt atg ttt acg gca aac tcg atg aac 624 Pro Thr Cys Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn 195 200 205 tgc ctg acc gaa gca ctc ggg ctg tcc ctg ccg ggc aac ggt tct tac 672 Cys Leu Thr Glu Ala Leu Gly Leu Ser Leu Pro Gly Asn Gly Ser Tyr 210 215 220 ctc gcc acc cac gtc ggc cgc aaa gaa ctg ttc ctc gaa gcc ggc cgt 720 Leu Ala Thr His Val Gly Arg Lys Glu Leu Phe Leu Glu Ala Gly Arg 225 230 235 240 atg att gtc gaa atc acc aaa cgc tat tac gag caa aac gat gaa acc 768 Met Ile Val Glu Ile Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Thr 245 250 255 gtg tta ccg cgc agc att gcc acc aaa aaa gcg ttt gaa aac gct atg 816 Val Leu Pro Arg Ser Ile Ala Thr Lys Lys Ala Phe Glu Asn Ala Met 260 265 270 acc atg gac att gcc atg ggc ggc agc acc aac act att ttg cat tta 864 Thr Met Asp Ile Ala Met Gly Gly Ser Thr Asn Thr Ile Leu His Leu 275 280 285 ctc gcc gtt gcc aac gaa gcg ggc gtg gat ttc aaa atg gca gac atc 912 Leu Ala Val Ala Asn Glu Ala Gly Val Asp Phe Lys Met Ala Asp Ile 290 295 300 gac cgc tta agc cgc gtt gtg ccc tgc atc tgc aaa acc gca ccc aac 960 Asp Arg Leu Ser Arg Val Val Pro Cys Ile Cys Lys Thr Ala Pro Asn 305 310 315 320 aac cac gac tac tat atg gaa gac gtg cac cga gcc ggc ggc atc ttc 1008 Asn His Asp Tyr Tyr Met Glu Asp Val His Arg Ala Gly Gly Ile Phe 325 330 335 gcc atc ctg aaa gaa ttg gac aaa gcg ggc aag ctg cac acc gac gtg 1056 Ala Ile Leu Lys Glu Leu Asp Lys Ala Gly Lys Leu His Thr Asp Val 340 345 350 cac act atc cac gcg ccg acg ctg aaa gac gcg att gaa aaa tgg gac 1104 His Thr Ile His Ala Pro Thr Leu Lys Asp Ala Ile Glu Lys Trp Asp 355 360 365 gta acc aac cct gaa aac acc cac gcc atc gaa cgc ttc aaa gcc gcg 1152 Val Thr Asn Pro Glu Asn Thr His Ala Ile Glu Arg Phe Lys Ala Ala 370 375 380 ccc ggc ggc gta cgc acc acc caa gcg ttc tcg caa aac cgt atg tgg 1200 Pro Gly Gly Val Arg Thr Thr Gln Ala Phe Ser Gln Asn Arg Met Trp 385 390 395 400 aaa acc ctc gac ctc gac cgc gaa aaa ggc tgt atc cgc gac gtg gca 1248 Lys Thr Leu Asp Leu Asp Arg Glu Lys Gly Cys Ile Arg Asp Val Ala 405 410 415 cac gcc tac tcg caa gac ggc ggt ttg gcg gtc ttg ttc ggc aac atc 1296 His Ala Tyr Ser Gln Asp Gly Gly Leu Ala Val Leu Phe Gly Asn Ile 420 425 430 gcc gag cgc ggc tgc gtg gta aaa acc gca ggc gtg gac gag agc atc 1344 Ala Glu Arg Gly Cys Val Val Lys Thr Ala Gly Val Asp Glu Ser Ile 435 440 445 ctc aaa ttc acc ggc cgc gcc cgc gtg ttt gaa agc caa gaa gac gca 1392 Leu Lys Phe Thr Gly Arg Ala Arg Val Phe Glu Ser Gln Glu Asp Ala 450 455 460 gta gaa ggc att ttg ggc aac caa atc gtc gcc ggc gac atc gtc atc 1440 Val Glu Gly Ile Leu Gly Asn Gln Ile Val Ala Gly Asp Ile Val Ile 465 470 475 480 atc cgc tac gaa ggc ccg aaa ggc ggc ccg ggc atg cag gaa atg ctg 1488 Ile Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu 485 490 495 tat ccg act tcc tac ctg aaa tct aaa ggc ctc ggc aaa gcc tgc gct 1536 Tyr Pro Thr Ser Tyr Leu Lys Ser Lys Gly Leu Gly Lys Ala Cys Ala 500 505 510 ctc tta acc gac gga cgc ttc tcc ggc ggc aca tca ggt ttg tcc atc 1584 Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile 515 520 525 gga cac gcc tcg ccc gaa gcg gcg gaa ggt ggc gcg atc ggt ttg gta 1632 Gly His Ala Ser Pro Glu Ala Ala Glu Gly Gly Ala Ile Gly Leu Val 530 535 540 cac gaa ggc gat acc gtc gaa atc gac atc ccc aac cgc agc atc cgc 1680 His Glu Gly Asp Thr Val Glu Ile Asp Ile Pro Asn Arg Ser Ile Arg 545 550 555 560 ctt gtc att tcc gac gaa gaa ctc gcc gcc cgc cgt gcc gaa atg gaa 1728 Leu Val Ile Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Glu Met Glu 565 570 575 gca cgc ggc agc aaa gcg tgg aaa ccg gaa aac cgc gac cgc tac gtc 1776 Ala Arg Gly Ser Lys Ala Trp Lys Pro Glu Asn Arg Asp Arg Tyr Val 580 585 590 tcc gcc gca tta aga gct tac ggc gcg atg gcg act tcc gcc gac aaa 1824 Ser Ala Ala Leu Arg Ala Tyr Gly Ala Met Ala Thr Ser Ala Asp Lys 595 600 605 ggc gcg gtg cgc gac gta gcg caa atc gaa aga 1857 Gly Ala Val Arg Asp Val Ala Gln Ile Glu Arg 610 615 <210> 28 <211> 619 <212> PRT <213> Neisseria meningitidis <400> 28 Met Pro Glu Tyr Arg Ser Lys Thr Ser Thr His Gly Arg Asn Met Ala 1 5 10 15 Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Val Met Glu Thr Asp Phe 20 25 30 Gly Lys Pro Ile Ile Ala Val Ala Asn Ser Phe Thr Gln Phe Val Pro 35 40 45 Gly His Val His Leu His Asn Met Gly Gln Leu Val Ala Arg Glu Ile 50 55 60 Glu Lys Ala Gly Ala Ile Ala Lys Glu Phe Asn Thr Ile Ala Ile Asp 65 70 75 80 Asp Gly Ile Ala Met Gly His Ser Gly Met Leu Tyr Ser Leu Pro Ser 85 90 95 Arg Asp Leu Ile Ala Asp Ser Ile Glu Tyr Met Val Asn Ala His Cys 100 105 110 Ala Asp Ala Leu Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 115 120 125 Met Leu Ile Ala Ala Met Arg Leu Asn Ile Pro Thr Ile Phe Val Ser 130 135 140 Gly Gly Pro Met Glu Ala Gly Lys Val Ile Gly Val Ala Asn Ile Gln 145 150 155 160 Pro Glu Arg Arg Leu Asp Leu Ile Asp Ala Met Ile Glu Ser Ala Asp 165 170 175 Asp Asn Ile Ser Asn Arg Gln Val Glu Glu Val Glu Gln Asn Ala Cys 180 185 190 Pro Thr Cys Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn 195 200 205 Cys Leu Thr Glu Ala Leu Gly Leu Ser Leu Pro Gly Asn Gly Ser Tyr 210 215 220 Leu Ala Thr His Val Gly Arg Lys Glu Leu Phe Leu Glu Ala Gly Arg 225 230 235 240 Met Ile Val Glu Ile Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Thr 245 250 255 Val Leu Pro Arg Ser Ile Ala Thr Lys Lys Ala Phe Glu Asn Ala Met 260 265 270 Thr Met Asp Ile Ala Met Gly Gly Ser Thr Asn Thr Ile Leu His Leu 275 280 285 Leu Ala Val Ala Asn Glu Ala Gly Val Asp Phe Lys Met Ala Asp Ile 290 295 300 Asp Arg Leu Ser Arg Val Val Pro Cys Ile Cys Lys Thr Ala Pro Asn 305 310 315 320 Asn His Asp Tyr Tyr Met Glu Asp Val His Arg Ala Gly Gly Ile Phe 325 330 335 Ala Ile Leu Lys Glu Leu Asp Lys Ala Gly Lys Leu His Thr Asp Val 340 345 350 His Thr Ile His Ala Pro Thr Leu Lys Asp Ala Ile Glu Lys Trp Asp 355 360 365 Val Thr Asn Pro Glu Asn Thr His Ala Ile Glu Arg Phe Lys Ala Ala 370 375 380 Pro Gly Gly Val Arg Thr Thr Gln Ala Phe Ser Gln Asn Arg Met Trp 385 390 395 400 Lys Thr Leu Asp Leu Asp Arg Glu Lys Gly Cys Ile Arg Asp Val Ala 405 410 415 His Ala Tyr Ser Gln Asp Gly Gly Leu Ala Val Leu Phe Gly Asn Ile 420 425 430 Ala Glu Arg Gly Cys Val Val Lys Thr Ala Gly Val Asp Glu Ser Ile 435 440 445 Leu Lys Phe Thr Gly Arg Ala Arg Val Phe Glu Ser Gln Glu Asp Ala 450 455 460 Val Glu Gly Ile Leu Gly Asn Gln Ile Val Ala Gly Asp Ile Val Ile 465 470 475 480 Ile Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu 485 490 495 Tyr Pro Thr Ser Tyr Leu Lys Ser Lys Gly Leu Gly Lys Ala Cys Ala 500 505 510 Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile 515 520 525 Gly His Ala Ser Pro Glu Ala Ala Glu Gly Gly Ala Ile Gly Leu Val 530 535 540 His Glu Gly Asp Thr Val Glu Ile Asp Ile Pro Asn Arg Ser Ile Arg 545 550 555 560 Leu Val Ile Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Glu Met Glu 565 570 575 Ala Arg Gly Ser Lys Ala Trp Lys Pro Glu Asn Arg Asp Arg Tyr Val 580 585 590 Ser Ala Ala Leu Arg Ala Tyr Gly Ala Met Ala Thr Ser Ala Asp Lys 595 600 605 Gly Ala Val Arg Asp Val Ala Gln Ile Glu Arg 610 615 <210> 29 <211> 1725 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1725) <400> 29 atg cag cta tca ggc gcg caa atc ata gtg cag agt ctc aaa gcc gaa 48 Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu 1 5 10 15 ggt gtc gag tac gtt ttc ggt tat ccc ggc ggt gcg gtt atc gaa atc 96 Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile 20 25 30 tac gat gcc ctt ttc caa ctc aat aaa ttc aag cac att ctg acc cgt 144 Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg 35 40 45 cac gag cag gcg gca gta cac gcg gca gat gcg tat gcg cgc gtc agc 192 His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser 50 55 60 ggt aag gtg ggc gtg gca ttg gtt aca tcc ggc ccg ggc gtt acc aat 240 Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn 65 70 75 80 gca ctg acc ggt att gct act gcc tat acg gat tcg att ccg atg gtg 288 Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val 85 90 95 gtc atc agc ggg cag gta ggc aat tcc ctg att ggt acg gat gcg ttc 336 Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe 100 105 110 caa gaa gtt gat acg gtg ggt att acc cgt ccg tgc gtc aaa cac aat 384 Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn 115 120 125 ttc ctg gtt acg gac atc aat gag ttg gcg gaa acc att aaa aag gcg 432 Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala 130 135 140 ttc caa att gcc gca agc ggc cga ccg ggg ccc gtg gtg gtt gat gtc 480 Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val 145 150 155 160 ccg aaa gat gtt acg cag gcg atg gcg aaa ttc agc tat cct cag gaa 528 Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu 165 170 175 gac att ttt atc cgt tcg tat caa ccg gtt gtt caa ggg cat atc ggt 576 Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly 180 185 190 cag att aaa aag gcc gtg cag atg ttg gca tct gcc aaa cgt ccg gtc 624 Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val 195 200 205 gtc tat ttt ggc ggc ggc gtg gtg ttg ggt aat gct tct gaa gag ctg 672 Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu 210 215 220 acc cga ttt gtc cga atg acg ggt gct ccg tgc acg ggt acg ctg atg 720 Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met 225 230 235 240 ggc ttg ggc gct tat cct tcc ggc gac cgc caa ttc ctc ggt atg ctc 768 Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu 245 250 255 ggt atg cac ggt act tac gag gca aac ctt gcc atg cag aat gcg gat 816 Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp 260 265 270 gtc gtt ctt gcc gta ggt gcg cgt ttt gac gac cgt gtg gtt tcc gta 864 Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val 275 280 285 ccg tcc aaa ttt ttc gag aag gcg aag aag gtt atc cat atc gat gtc 912 Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val 290 295 300 gat cct tcc agc atc gcc aaa cgc gtg aag gcg gac att ccg att gtc 960 Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val 305 310 315 320 ggc gac gtg aaa aac gtt ttg tcc gag atg gtt gcg ctg tgg caa aaa 1008 Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys 325 330 335 caa gag tcc gtg ccg tct gaa gat gct ttg ggc aaa tgg tgg aaa acc 1056 Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr 340 345 350 ata gag gaa tgg cgt tcc cgc gat tgc ttg tgg ttt gac aac ggc agc 1104 Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser 355 360 365 gaa att atc aag cca caa tat gtg att cag aag ctt gcc gag att acc 1152 Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr 370 375 380 ggc aat tcg gca atc atc aca tcg gat gta ggg cag cat caa atg ttt 1200 Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe 385 390 395 400 gcg gct caa tat tat ccc ttc gaa cgt ccg cgc caa tgg ctc aac tcc 1248 Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser 405 410 415 ggc ggt ttg ggt acg atg ggc gtt ggt ctg cct tat gcg att ggt gca 1296 Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala 420 425 430 aaa ctt gcc gcc ccg gat caa gac gta ttc tgt att acc ggc gac ggc 1344 Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly 435 440 445 tcg atc cag atg aac atc caa gag ctg tcc acc tgt ttc caa tat cgg 1392 Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg 450 455 460 att ccg gtt aac gtc att acg ctg aac aac ggt tat ctc ggt atg gta 1440 Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val 465 470 475 480 cgc cag tgg cag gaa ata tat tac ggc gga cga gag tcg gaa acc tat 1488 Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr 485 490 495 ttc gat tct ttg ccc gat ttc gtc aaa ctt gcc gag gca tac ggc cat 1536 Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His 500 505 510 atc ggt atc cgc gtg gac aag aag tct gat gtg gaa ggt gcg ttg ttg 1584 Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu 515 520 525 gaa gca ttg aac caa aaa gac agg ctg gtg ttt atc gac ttc ctg acc 1632 Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr 530 535 540 gac cag aaa cag aat gtg atg ccc atg gtc ggc aac ggc aaa ggt ttg 1680 Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu 545 550 555 560 gac gaa atg gta ctt ccg ccg cat atg cgt gcg gac gga aag gcg 1725 Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala 565 570 575 <210> 30 <211> 575 <212> PRT <213> Neisseria meningitidis <400> 30 Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu 1 5 10 15 Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile 20 25 30 Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg 35 40 45 His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser 50 55 60 Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn 65 70 75 80 Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val 85 90 95 Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe 100 105 110 Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn 115 120 125 Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala 130 135 140 Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val 145 150 155 160 Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu 165 170 175 Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly 180 185 190 Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val 195 200 205 Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu 210 215 220 Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met 225 230 235 240 Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu 245 250 255 Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp 260 265 270 Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val 275 280 285 Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val 290 295 300 Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val 305 310 315 320 Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys 325 330 335 Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr 340 345 350 Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser 355 360 365 Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr 370 375 380 Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe 385 390 395 400 Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser 405 410 415 Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala 420 425 430 Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly 435 440 445 Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg 450 455 460 Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val 465 470 475 480 Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr 485 490 495 Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His 500 505 510 Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu 515 520 525 Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr 530 535 540 Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu 545 550 555 560 Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala 565 570 575 <210> 31 <211> 651 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(651) <400> 31 atg ttt tcc gta ccg cgt tcc ttt ttg ccg ggc gtt ttc gta ctt gcc 48 Met Phe Ser Val Pro Arg Ser Phe Leu Pro Gly Val Phe Val Leu Ala 1 5 10 15 gcg ctt gcc gcc tgc aaa cct caa gac aac agt gcg gcg caa gtc gct 96 Ala Leu Ala Ala Cys Lys Pro Gln Asp Asn Ser Ala Ala Gln Val Ala 20 25 30 tct tca agt gca tcc gcg tcg gct gcg gaa aat gcg gca aag ccg caa 144 Ser Ser Ser Ala Ser Ala Ser Ala Ala Glu Asn Ala Ala Lys Pro Gln 35 40 45 acg cgc ggt acg gat atg cgt aag gaa gac atc ggc ggc gat ttc acg 192 Thr Arg Gly Thr Asp Met Arg Lys Glu Asp Ile Gly Gly Asp Phe Thr 50 55 60 ctg acc gac ggc gaa ggc aag cct ttc aac ctg agc gat ttg aaa ggc 240 Leu Thr Asp Gly Glu Gly Lys Pro Phe Asn Leu Ser Asp Leu Lys Gly 65 70 75 80 aag gtc gtg att ctg tct ttc ggc ttt acg cac tgt ccc gat gtc tgc 288 Lys Val Val Ile Leu Ser Phe Gly Phe Thr His Cys Pro Asp Val Cys 85 90 95 ccg aca gag ctt ttg acg tac agc gac acg ttg aag cag ttg ggc ggg 336 Pro Thr Glu Leu Leu Thr Tyr Ser Asp Thr Leu Lys Gln Leu Gly Gly 100 105 110 cag gct aag gac gtg aaa gtg gtg ttc gtc agc atc gat ccg gaa cgc 384 Gln Ala Lys Asp Val Lys Val Val Phe Val Ser Ile Asp Pro Glu Arg 115 120 125 gac acg cct gaa atc atc ggc aag tat gcc aaa cag ttc aat ccg gac 432 Asp Thr Pro Glu Ile Ile Gly Lys Tyr Ala Lys Gln Phe Asn Pro Asp 130 135 140 ttt atc ggt ctg acg gca acg ggc gac caa aac ctg ccg gtc atc aag 480 Phe Ile Gly Leu Thr Ala Thr Gly Asp Gln Asn Leu Pro Val Ile Lys 145 150 155 160 cag caa tac cgc gtg gtt tct gcc aaa gtc aat caa aaa gac gac agc 528 Gln Gln Tyr Arg Val Val Ser Ala Lys Val Asn Gln Lys Asp Asp Ser 165 170 175 gaa aac tat ttg gtc gac cac tct tcc ggt gcg tat ctc atc gac aaa 576 Glu Asn Tyr Leu Val Asp His Ser Ser Gly Ala Tyr Leu Ile Asp Lys 180 185 190 aac ggt gag gtt gcc att ttc tcg cct tac gga agc gag ccg gaa acg 624 Asn Gly Glu Val Ala Ile Phe Ser Pro Tyr Gly Ser Glu Pro Glu Thr 195 200 205 att gct gcc gat gta agg acc ctg ctc 651 Ile Ala Ala Asp Val Arg Thr Leu Leu 210 215 <210> 32 <211> 217 <212> PRT <213> Neisseria meningitidis <400> 32 Met Phe Ser Val Pro Arg Ser Phe Leu Pro Gly Val Phe Val Leu Ala 1 5 10 15 Ala Leu Ala Ala Cys Lys Pro Gln Asp Asn Ser Ala Ala Gln Val Ala 20 25 30 Ser Ser Ser Ala Ser Ala Ser Ala Ala Glu Asn Ala Ala Lys Pro Gln 35 40 45 Thr Arg Gly Thr Asp Met Arg Lys Glu Asp Ile Gly Gly Asp Phe Thr 50 55 60 Leu Thr Asp Gly Glu Gly Lys Pro Phe Asn Leu Ser Asp Leu Lys Gly 65 70 75 80 Lys Val Val Ile Leu Ser Phe Gly Phe Thr His Cys Pro Asp Val Cys 85 90 95 Pro Thr Glu Leu Leu Thr Tyr Ser Asp Thr Leu Lys Gln Leu Gly Gly 100 105 110 Gln Ala Lys Asp Val Lys Val Val Phe Val Ser Ile Asp Pro Glu Arg 115 120 125 Asp Thr Pro Glu Ile Ile Gly Lys Tyr Ala Lys Gln Phe Asn Pro Asp 130 135 140 Phe Ile Gly Leu Thr Ala Thr Gly Asp Gln Asn Leu Pro Val Ile Lys 145 150 155 160 Gln Gln Tyr Arg Val Val Ser Ala Lys Val Asn Gln Lys Asp Asp Ser 165 170 175 Glu Asn Tyr Leu Val Asp His Ser Ser Gly Ala Tyr Leu Ile Asp Lys 180 185 190 Asn Gly Glu Val Ala Ile Phe Ser Pro Tyr Gly Ser Glu Pro Glu Thr 195 200 205 Ile Ala Ala Asp Val Arg Thr Leu Leu 210 215 <210> 33 <211> 330 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(330) <400> 33 ttg ccg ctg ctt tgt tgt ctt tgg ttt tgg cag cct gcg gcg gtg aaa 48 Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys 1 5 10 15 aag ccg ctg aag ctc ccg ctg ctg aag cac ctg ccg ccg aag ctc ccg 96 Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro 20 25 30 cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg aag cac ctg ccg 144 Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro 35 40 45 ccg aag ctc ctg cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg 192 Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu 50 55 60 aag ctg ccg cta ccg aag cac ctg ccg ctg aag ctg ccg cta ccg aag 240 Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys 65 70 75 80 cac ctg ccg ctg aag ctc ctg ctg ccg aag ctg caa aat aag cat ttt 288 His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe 85 90 95 ccg ctt gca aaa aag cag gat acg ttc agt atc ctg ctt ttt 330 Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe 100 105 110 <210> 34 <211> 110 <212> PRT <213> Neisseria meningitidis <400> 34 Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys 1 5 10 15 Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro 20 25 30 Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro 35 40 45 Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu 50 55 60 Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys 65 70 75 80 His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe 85 90 95 Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe 100 105 110 <210> 35 <211> 2118 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2118) <400> 35 atg ttc gac aaa cac gtt aag acc ttc caa tac ggt aat cag acc gtt 48 Met Phe Asp Lys His Val Lys Thr Phe Gln Tyr Gly Asn Gln Thr Val 1 5 10 15 act ttg gaa acc ggc gaa att gcc cgc caa gcc gcc gct gcc gtt aaa 96 Thr Leu Glu Thr Gly Glu Ile Ala Arg Gln Ala Ala Ala Ala Val Lys 20 25 30 gtc tct atg ggc gac acc gtg gtt ttg gtt gcc gtt acc acc aac aaa 144 Val Ser Met Gly Asp Thr Val Val Leu Val Ala Val Thr Thr Asn Lys 35 40 45 gaa gtg aaa gaa ggc caa gac ttc ttc ccc ctg acc gtc gat tat ttg 192 Glu Val Lys Glu Gly Gln Asp Phe Phe Pro Leu Thr Val Asp Tyr Leu 50 55 60 gaa cgc act tac gcc gca ggt aaa atc ccc ggc ggt ttc ttc aaa cgc 240 Glu Arg Thr Tyr Ala Ala Gly Lys Ile Pro Gly Gly Phe Phe Lys Arg 65 70 75 80 gaa ggc aaa caa agc gaa aaa gaa atc ctg acc agc cgt ctg atc gac 288 Glu Gly Lys Gln Ser Glu Lys Glu Ile Leu Thr Ser Arg Leu Ile Asp 85 90 95 cgc ccg att cgt ccg ctg ttc ccc gaa ggt ttc tac cac gac atc caa 336 Arg Pro Ile Arg Pro Leu Phe Pro Glu Gly Phe Tyr His Asp Ile Gln 100 105 110 atc gta gcg atg gtc gtg tcc gtc gat ccc gaa atc gat tcc gac att 384 Ile Val Ala Met Val Val Ser Val Asp Pro Glu Ile Asp Ser Asp Ile 115 120 125 cct gca atg ttg ggc gcg tct gcc gcg ctg gtg ttg agc ggc gta ccg 432 Pro Ala Met Leu Gly Ala Ser Ala Ala Leu Val Leu Ser Gly Val Pro 130 135 140 ttt gcc ggt ccg att ggt gcg gca cgc gtg ggt tat ata aac ggc gtg 480 Phe Ala Gly Pro Ile Gly Ala Ala Arg Val Gly Tyr Ile Asn Gly Val 145 150 155 160 tac gtt ttg aac ccg act aaa gcc gaa ttg gcg aaa tcg caa ttg gac 528 Tyr Val Leu Asn Pro Thr Lys Ala Glu Leu Ala Lys Ser Gln Leu Asp 165 170 175 ttg gtg gtc gcc ggt act tca aaa gcc gtg ttg atg gtg gaa tcc gaa 576 Leu Val Val Ala Gly Thr Ser Lys Ala Val Leu Met Val Glu Ser Glu 180 185 190 gcc aaa atc ctg ccc gaa gac gtg atg ctg ggc gcg gtg gtt tac ggc 624 Ala Lys Ile Leu Pro Glu Asp Val Met Leu Gly Ala Val Val Tyr Gly 195 200 205 cac gat caa atg cag gtt gcc atc aat gca atc aat gaa ttt gcc gac 672 His Asp Gln Met Gln Val Ala Ile Asn Ala Ile Asn Glu Phe Ala Asp 210 215 220 gaa gtc aat ccg gaa ctt tgg gat tgg aaa gca cct gaa acc aat gag 720 Glu Val Asn Pro Glu Leu Trp Asp Trp Lys Ala Pro Glu Thr Asn Glu 225 230 235 240 gaa ctg gtt gcc aaa gtc cgc ggg att gcc ggc gaa acc att aaa gaa 768 Glu Leu Val Ala Lys Val Arg Gly Ile Ala Gly Glu Thr Ile Lys Glu 245 250 255 gcg ttc aaa atc cgt caa aaa caa gcg cgt tct gcc aaa ttg gac gaa 816 Ala Phe Lys Ile Arg Gln Lys Gln Ala Arg Ser Ala Lys Leu Asp Glu 260 265 270 gct tgg agt gcg gta aaa gaa gcc ttg att acc gaa gaa acc gac acg 864 Ala Trp Ser Ala Val Lys Glu Ala Leu Ile Thr Glu Glu Thr Asp Thr 275 280 285 ctg gca gcc aac gaa atc aaa ggc att ttc aaa cac ttg gaa gcc gat 912 Leu Ala Ala Asn Glu Ile Lys Gly Ile Phe Lys His Leu Glu Ala Asp 290 295 300 gtc gtc cgc agc caa att ttg gac ggc caa ccg cgc atc gac ggc cgc 960 Val Val Arg Ser Gln Ile Leu Asp Gly Gln Pro Arg Ile Asp Gly Arg 305 310 315 320 gac acc cgc acc gtc cgt ccg ctg aac atc caa acc ggc gta ttg ccg 1008 Asp Thr Arg Thr Val Arg Pro Leu Asn Ile Gln Thr Gly Val Leu Pro 325 330 335 cgc acg cac ggt tcc gca ttg ttt acc cgt ggc gaa acc caa gcc ctt 1056 Arg Thr His Gly Ser Ala Leu Phe Thr Arg Gly Glu Thr Gln Ala Leu 340 345 350 gcc gta gcg act ttg ggt act tcg cgc gac gag caa atc atc gac gcg 1104 Ala Val Ala Thr Leu Gly Thr Ser Arg Asp Glu Gln Ile Ile Asp Ala 355 360 365 ctg tcc ggc gaa tac acc gac cgc ttt atg ctg cac tac aac ttt ccg 1152 Leu Ser Gly Glu Tyr Thr Asp Arg Phe Met Leu His Tyr Asn Phe Pro 370 375 380 ccg tac tct acc ggc gaa gtg ggc cgc atg ggc gcg ccg aaa cgc cgt 1200 Pro Tyr Ser Thr Gly Glu Val Gly Arg Met Gly Ala Pro Lys Arg Arg 385 390 395 400 gaa atc ggt cac ggt cgt ttg gct aaa cgt gca ttg ttg gcc gta ttg 1248 Glu Ile Gly His Gly Arg Leu Ala Lys Arg Ala Leu Leu Ala Val Leu 405 410 415 ccg aaa cct gaa gat ttc agc tac acc atg cgc gtg gtc tcc gaa att 1296 Pro Lys Pro Glu Asp Phe Ser Tyr Thr Met Arg Val Val Ser Glu Ile 420 425 430 acc gaa tcc aac ggc tct tcc tct atg gct tcc gtc tgc ggc ggc tgc 1344 Thr Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val Cys Gly Gly Cys 435 440 445 ttg agc ctg ctg tcc gcc ggc gtg cct ttg aaa gca cac gtt gcc ggt 1392 Leu Ser Leu Leu Ser Ala Gly Val Pro Leu Lys Ala His Val Ala Gly 450 455 460 atc gcg atg ggt ctg att ctg gaa ggc aat aag ttt gcc gtc ctg acc 1440 Ile Ala Met Gly Leu Ile Leu Glu Gly Asn Lys Phe Ala Val Leu Thr 465 470 475 480 gac att ttg ggc gac gaa gac cac ttg ggc gat atg gac ttt aaa gtg 1488 Asp Ile Leu Gly Asp Glu Asp His Leu Gly Asp Met Asp Phe Lys Val 485 490 495 gct ggt acg acc gaa ggc gtt acc gcg ctg caa atg gac atc aaa atc 1536 Ala Gly Thr Thr Glu Gly Val Thr Ala Leu Gln Met Asp Ile Lys Ile 500 505 510 caa ggc att acc aaa gag att atg caa atc gct ttg gcg cag gcc aaa 1584 Gln Gly Ile Thr Lys Glu Ile Met Gln Ile Ala Leu Ala Gln Ala Lys 515 520 525 gaa gcg cgt ctg cac atc ttg gat cag atg aaa gcc gcc gtt gcg ggc 1632 Glu Ala Arg Leu His Ile Leu Asp Gln Met Lys Ala Ala Val Ala Gly 530 535 540 ccg caa gag ctg tcc gca cac gcg cca cgc ttg ttc acg atg aaa atc 1680 Pro Gln Glu Leu Ser Ala His Ala Pro Arg Leu Phe Thr Met Lys Ile 545 550 555 560 aac caa gac aaa atc cgc gaa gtt atc ggt aag ggc ggt gaa acc atc 1728 Asn Gln Asp Lys Ile Arg Glu Val Ile Gly Lys Gly Gly Glu Thr Ile 565 570 575 cgt gcg att acc gct gaa acc ggt acg gaa atc aat att gcc gaa gac 1776 Arg Ala Ile Thr Ala Glu Thr Gly Thr Glu Ile Asn Ile Ala Glu Asp 580 585 590 ggt acg att acc att gcc gca acc act caa gaa gcc ggc gat gcg gcg 1824 Gly Thr Ile Thr Ile Ala Ala Thr Thr Gln Glu Ala Gly Asp Ala Ala 595 600 605 aaa aaa cgc atc gag cag att act gcc gaa gtg gaa gtg ggc aaa gtg 1872 Lys Lys Arg Ile Glu Gln Ile Thr Ala Glu Val Glu Val Gly Lys Val 610 615 620 tac gaa ggc act gtg gtg aaa atc ctc gac aac aat gtc ggc gcg att 1920 Tyr Glu Gly Thr Val Val Lys Ile Leu Asp Asn Asn Val Gly Ala Ile 625 630 635 640 gtc agt gtg atg ccg ggc aaa gac ggt ttg gta cac atc agc caa atc 1968 Val Ser Val Met Pro Gly Lys Asp Gly Leu Val His Ile Ser Gln Ile 645 650 655 gcc cac gag cgc gta cgc aat gtc ggc gac tac ctg caa gtc ggt cag 2016 Ala His Glu Arg Val Arg Asn Val Gly Asp Tyr Leu Gln Val Gly Gln 660 665 670 gtg gtg aac gtg aaa gca ttg gaa gtg gac gac aga ggc cgt gtc cgt 2064 Val Val Asn Val Lys Ala Leu Glu Val Asp Asp Arg Gly Arg Val Arg 675 680 685 ctg tcc atc aaa gcc ctg ctg gac gcg cct gcc cgt gag gaa aat gcc 2112 Leu Ser Ile Lys Ala Leu Leu Asp Ala Pro Ala Arg Glu Glu Asn Ala 690 695 700 gcc gag 2118 Ala Glu 705 <210> 36 <211> 706 <212> PRT <213> Neisseria meningitidis <400> 36 Met Phe Asp Lys His Val Lys Thr Phe Gln Tyr Gly Asn Gln Thr Val 1 5 10 15 Thr Leu Glu Thr Gly Glu Ile Ala Arg Gln Ala Ala Ala Ala Val Lys 20 25 30 Val Ser Met Gly Asp Thr Val Val Leu Val Ala Val Thr Thr Asn Lys 35 40 45 Glu Val Lys Glu Gly Gln Asp Phe Phe Pro Leu Thr Val Asp Tyr Leu 50 55 60 Glu Arg Thr Tyr Ala Ala Gly Lys Ile Pro Gly Gly Phe Phe Lys Arg 65 70 75 80 Glu Gly Lys Gln Ser Glu Lys Glu Ile Leu Thr Ser Arg Leu Ile Asp 85 90 95 Arg Pro Ile Arg Pro Leu Phe Pro Glu Gly Phe Tyr His Asp Ile Gln 100 105 110 Ile Val Ala Met Val Val Ser Val Asp Pro Glu Ile Asp Ser Asp Ile 115 120 125 Pro Ala Met Leu Gly Ala Ser Ala Ala Leu Val Leu Ser Gly Val Pro 130 135 140 Phe Ala Gly Pro Ile Gly Ala Ala Arg Val Gly Tyr Ile Asn Gly Val 145 150 155 160 Tyr Val Leu Asn Pro Thr Lys Ala Glu Leu Ala Lys Ser Gln Leu Asp 165 170 175 Leu Val Val Ala Gly Thr Ser Lys Ala Val Leu Met Val Glu Ser Glu 180 185 190 Ala Lys Ile Leu Pro Glu Asp Val Met Leu Gly Ala Val Val Tyr Gly 195 200 205 His Asp Gln Met Gln Val Ala Ile Asn Ala Ile Asn Glu Phe Ala Asp 210 215 220 Glu Val Asn Pro Glu Leu Trp Asp Trp Lys Ala Pro Glu Thr Asn Glu 225 230 235 240 Glu Leu Val Ala Lys Val Arg Gly Ile Ala Gly Glu Thr Ile Lys Glu 245 250 255 Ala Phe Lys Ile Arg Gln Lys Gln Ala Arg Ser Ala Lys Leu Asp Glu 260 265 270 Ala Trp Ser Ala Val Lys Glu Ala Leu Ile Thr Glu Glu Thr Asp Thr 275 280 285 Leu Ala Ala Asn Glu Ile Lys Gly Ile Phe Lys His Leu Glu Ala Asp 290 295 300 Val Val Arg Ser Gln Ile Leu Asp Gly Gln Pro Arg Ile Asp Gly Arg 305 310 315 320 Asp Thr Arg Thr Val Arg Pro Leu Asn Ile Gln Thr Gly Val Leu Pro 325 330 335 Arg Thr His Gly Ser Ala Leu Phe Thr Arg Gly Glu Thr Gln Ala Leu 340 345 350 Ala Val Ala Thr Leu Gly Thr Ser Arg Asp Glu Gln Ile Ile Asp Ala 355 360 365 Leu Ser Gly Glu Tyr Thr Asp Arg Phe Met Leu His Tyr Asn Phe Pro 370 375 380 Pro Tyr Ser Thr Gly Glu Val Gly Arg Met Gly Ala Pro Lys Arg Arg 385 390 395 400 Glu Ile Gly His Gly Arg Leu Ala Lys Arg Ala Leu Leu Ala Val Leu 405 410 415 Pro Lys Pro Glu Asp Phe Ser Tyr Thr Met Arg Val Val Ser Glu Ile 420 425 430 Thr Glu Ser Asn Gly Ser Ser Ser Met Ala Ser Val Cys Gly Gly Cys 435 440 445 Leu Ser Leu Leu Ser Ala Gly Val Pro Leu Lys Ala His Val Ala Gly 450 455 460 Ile Ala Met Gly Leu Ile Leu Glu Gly Asn Lys Phe Ala Val Leu Thr 465 470 475 480 Asp Ile Leu Gly Asp Glu Asp His Leu Gly Asp Met Asp Phe Lys Val 485 490 495 Ala Gly Thr Thr Glu Gly Val Thr Ala Leu Gln Met Asp Ile Lys Ile 500 505 510 Gln Gly Ile Thr Lys Glu Ile Met Gln Ile Ala Leu Ala Gln Ala Lys 515 520 525 Glu Ala Arg Leu His Ile Leu Asp Gln Met Lys Ala Ala Val Ala Gly 530 535 540 Pro Gln Glu Leu Ser Ala His Ala Pro Arg Leu Phe Thr Met Lys Ile 545 550 555 560 Asn Gln Asp Lys Ile Arg Glu Val Ile Gly Lys Gly Gly Glu Thr Ile 565 570 575 Arg Ala Ile Thr Ala Glu Thr Gly Thr Glu Ile Asn Ile Ala Glu Asp 580 585 590 Gly Thr Ile Thr Ile Ala Ala Thr Thr Gln Glu Ala Gly Asp Ala Ala 595 600 605 Lys Lys Arg Ile Glu Gln Ile Thr Ala Glu Val Glu Val Gly Lys Val 610 615 620 Tyr Glu Gly Thr Val Val Lys Ile Leu Asp Asn Asn Val Gly Ala Ile 625 630 635 640 Val Ser Val Met Pro Gly Lys Asp Gly Leu Val His Ile Ser Gln Ile 645 650 655 Ala His Glu Arg Val Arg Asn Val Gly Asp Tyr Leu Gln Val Gly Gln 660 665 670 Val Val Asn Val Lys Ala Leu Glu Val Asp Asp Arg Gly Arg Val Arg 675 680 685 Leu Ser Ile Lys Ala Leu Leu Asp Ala Pro Ala Arg Glu Glu Asn Ala 690 695 700 Ala Glu 705 <210> 37 <211> 3972 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(3972) <400> 37 gtg agc cga att atg tct gtc gtt ttg ccc ttg cgc ggc gtt acc gcc 48 Val Ser Arg Ile Met Ser Val Val Leu Pro Leu Arg Gly Val Thr Ala 1 5 10 15 ctt tcc gat ttc cgt gtt gaa aaa ctc ttg caa aaa gcc gcc gca ctc 96 Leu Ser Asp Phe Arg Val Glu Lys Leu Leu Gln Lys Ala Ala Ala Leu 20 25 30 ggt ctg ccc gaa gtc aaa tta agc agc gaa ttt tgg tat ttc gtc ggc 144 Gly Leu Pro Glu Val Lys Leu Ser Ser Glu Phe Trp Tyr Phe Val Gly 35 40 45 agc gag aaa gca ctt gat gcc gcg act gtc gaa aaa ctg caa gcc ttg 192 Ser Glu Lys Ala Leu Asp Ala Ala Thr Val Glu Lys Leu Gln Ala Leu 50 55 60 ttg gcg gcg caa agc gtt gaa caa acg cca aaa gcg cgc gag ggc ttg 240 Leu Ala Ala Gln Ser Val Glu Gln Thr Pro Lys Ala Arg Glu Gly Leu 65 70 75 80 cat ttg ttt ttg gtc acg ccc cgt ttg ggt acg att tcg ccg tgg gct 288 His Leu Phe Leu Val Thr Pro Arg Leu Gly Thr Ile Ser Pro Trp Ala 85 90 95 tcc aag gcg acc aat atc gcg gaa aac tgc ggt ttg gca ggc atc gaa 336 Ser Lys Ala Thr Asn Ile Ala Glu Asn Cys Gly Leu Ala Gly Ile Glu 100 105 110 cgc atc gag cgc ggc atg gcg gtg tgg ctg gaa ggt gcg ctt acc gat 384 Arg Ile Glu Arg Gly Met Ala Val Trp Leu Glu Gly Ala Leu Thr Asp 115 120 125 gaa cag caa cag caa tgg gcg gct ttg ctg cac gac cgc atg act gaa 432 Glu Gln Gln Gln Gln Trp Ala Ala Leu Leu His Asp Arg Met Thr Glu 130 135 140 tcc gtg ctg ccc gat ttt cag acg gca tcc aaa tta ttc cac cat ctc 480 Ser Val Leu Pro Asp Phe Gln Thr Ala Ser Lys Leu Phe His His Leu 145 150 155 160 gaa tcc gaa acc ttt tcc acc gtc gat gtt ttg ggc ggc ggt aaa gag 528 Glu Ser Glu Thr Phe Ser Thr Val Asp Val Leu Gly Gly Gly Lys Glu 165 170 175 gct ttg gtc aaa gcc aat acc gaa atg ggt ttg gca ctc tcc gcc gac 576 Ala Leu Val Lys Ala Asn Thr Glu Met Gly Leu Ala Leu Ser Ala Asp 180 185 190 gaa atc gat tat ctg gtt gaa aac tat cag gct ttg cag cgc aat ccg 624 Glu Ile Asp Tyr Leu Val Glu Asn Tyr Gln Ala Leu Gln Arg Asn Pro 195 200 205 tct gat gtg gag ctg atg atg ttc gcg cag gca aac agc gaa cac tgc 672 Ser Asp Val Glu Leu Met Met Phe Ala Gln Ala Asn Ser Glu His Cys 210 215 220 cgc cac aaa atc ttc aac gcc gac ttc atc ctc aac ggc gaa aaa cag 720 Arg His Lys Ile Phe Asn Ala Asp Phe Ile Leu Asn Gly Glu Lys Gln 225 230 235 240 ccg aaa tcg ctc ttc ggt atg ata cgc gac acg cac aac gcg cat ccc 768 Pro Lys Ser Leu Phe Gly Met Ile Arg Asp Thr His Asn Ala His Pro 245 250 255 gaa ggc aca gtc gtt gcc tac aaa gac aac tca tcc gtg atc gaa ggc 816 Glu Gly Thr Val Val Ala Tyr Lys Asp Asn Ser Ser Val Ile Glu Gly 260 265 270 gca aaa gtc gaa cgt ttc tat cca aat gcg gca gaa aac caa ggc tac 864 Ala Lys Val Glu Arg Phe Tyr Pro Asn Ala Ala Glu Asn Gln Gly Tyr 275 280 285 cgt ttc cac gag gaa gac acg cat atc atc atg aaa gtg gaa acg cac 912 Arg Phe His Glu Glu Asp Thr His Ile Ile Met Lys Val Glu Thr His 290 295 300 aac cac ccg acc gcc atc gcg ccg ttt gcg ggc gcg gca acg ggc gcg 960 Asn His Pro Thr Ala Ile Ala Pro Phe Ala Gly Ala Ala Thr Gly Ala 305 310 315 320 ggc ggc gaa atc cgc gac gaa ggt gcg acg ggc aaa ggt tcg cgt ccg 1008 Gly Gly Glu Ile Arg Asp Glu Gly Ala Thr Gly Lys Gly Ser Arg Pro 325 330 335 aaa gca ggc ttg acc ggc ttt acc gtg tcc aac ctc aac atc ccc ggc 1056 Lys Ala Gly Leu Thr Gly Phe Thr Val Ser Asn Leu Asn Ile Pro Gly 340 345 350 ctc aaa cag ccg tgg gaa caa gat tac ggc aag ccg gaa cat att tcc 1104 Leu Lys Gln Pro Trp Glu Gln Asp Tyr Gly Lys Pro Glu His Ile Ser 355 360 365 tcg ccg ctg gac att atg att gaa ggc ccc atc ggc ggc gcg gcg ttc 1152 Ser Pro Leu Asp Ile Met Ile Glu Gly Pro Ile Gly Gly Ala Ala Phe 370 375 380 aac aac gaa ttc ggc cgc ccc aac ctc ttg ggc tac ttc cgc act ttt 1200 Asn Asn Glu Phe Gly Arg Pro Asn Leu Leu Gly Tyr Phe Arg Thr Phe 385 390 395 400 gaa gaa aaa ttt gac ggt cag gtt cgc ggc tac cac aaa ccg att atg 1248 Glu Glu Lys Phe Asp Gly Gln Val Arg Gly Tyr His Lys Pro Ile Met 405 410 415 att gcc ggc ggc ttg ggc agc att cag gcg cag cag acg cat aaa gac 1296 Ile Ala Gly Gly Leu Gly Ser Ile Gln Ala Gln Gln Thr His Lys Asp 420 425 430 gaa atc ccc gaa ggc gcg ttg ctg atc caa ctg ggc ggc ccg ggt atg 1344 Glu Ile Pro Glu Gly Ala Leu Leu Ile Gln Leu Gly Gly Pro Gly Met 435 440 445 ctt atc ggc ttg ggc ggc ggc gcg gct tct tcg atg gat acc ggc aca 1392 Leu Ile Gly Leu Gly Gly Gly Ala Ala Ser Ser Met Asp Thr Gly Thr 450 455 460 aac gac gcg tct tta gac ttc aac tcc gta caa cgc ggc aac ccc gaa 1440 Asn Asp Ala Ser Leu Asp Phe Asn Ser Val Gln Arg Gly Asn Pro Glu 465 470 475 480 atc gaa cgc cgc gcg cag gaa gtg atc gac cgc tgc tgg cag ctc ggc 1488 Ile Glu Arg Arg Ala Gln Glu Val Ile Asp Arg Cys Trp Gln Leu Gly 485 490 495 gac aaa aac ccg att atc tcc atc cac gac gtt ggc gcg ggc ggc ttg 1536 Asp Lys Asn Pro Ile Ile Ser Ile His Asp Val Gly Ala Gly Gly Leu 500 505 510 tcc aac gcc ttc ccc gaa ctc gtc aac gat gcc gga cgc ggc gcg gta 1584 Ser Asn Ala Phe Pro Glu Leu Val Asn Asp Ala Gly Arg Gly Ala Val 515 520 525 ttc aag ctg cgc gaa gtg ccg ctg gaa gaa cac ggt ctc aac ccg ctg 1632 Phe Lys Leu Arg Glu Val Pro Leu Glu Glu His Gly Leu Asn Pro Leu 530 535 540 caa atc tgg tgc aac gaa tcg caa gag cgt tat gta ttg tcg att ttg 1680 Gln Ile Trp Cys Asn Glu Ser Gln Glu Arg Tyr Val Leu Ser Ile Leu 545 550 555 560 gaa aaa gat ttg gac atc ttc cgc tcc atc tgc gaa cgt gaa cgc tgc 1728 Glu Lys Asp Leu Asp Ile Phe Arg Ser Ile Cys Glu Arg Glu Arg Cys 565 570 575 ccg ttt gcg gta gtc ggt acg gcg acc gac gac ggc cat ttg aaa gta 1776 Pro Phe Ala Val Val Gly Thr Ala Thr Asp Asp Gly His Leu Lys Val 580 585 590 cgc gac gat ttg ttc tcc aac aac cct gtc gat ttg ccg ttg aac gtc 1824 Arg Asp Asp Leu Phe Ser Asn Asn Pro Val Asp Leu Pro Leu Asn Val 595 600 605 ttg ctc ggc aaa ccg ccc aaa acc acg cgt acc gac aaa acg gtt gcg 1872 Leu Leu Gly Lys Pro Pro Lys Thr Thr Arg Thr Asp Lys Thr Val Ala 610 615 620 ccg tcc aaa aaa ccg ttt cac gcg ggc gat atc gac att act gaa gcc 1920 Pro Ser Lys Lys Pro Phe His Ala Gly Asp Ile Asp Ile Thr Glu Ala 625 630 635 640 gcc tac cgc gtt ctg cgc ctg cct gcc gta gcc gcc aaa aac ttc ctg 1968 Ala Tyr Arg Val Leu Arg Leu Pro Ala Val Ala Ala Lys Asn Phe Leu 645 650 655 att acc atc ggc gac cgc agc gtc ggc ggc atg acc cac cgc gac caa 2016 Ile Thr Ile Gly Asp Arg Ser Val Gly Gly Met Thr His Arg Asp Gln 660 665 670 atg gtc ggc aaa tac caa acc ccc gta gcc gac tgc gcc gtt acc atg 2064 Met Val Gly Lys Tyr Gln Thr Pro Val Ala Asp Cys Ala Val Thr Met 675 680 685 atg ggc ttc aac act tat cgc ggc gaa gcg atg agc atg ggc gaa aaa 2112 Met Gly Phe Asn Thr Tyr Arg Gly Glu Ala Met Ser Met Gly Glu Lys 690 695 700 ccg acc gtc gcc ctg ttt gac gcg cct gct tcg ggc aga atg tgc gtc 2160 Pro Thr Val Ala Leu Phe Asp Ala Pro Ala Ser Gly Arg Met Cys Val 705 710 715 720 ggc gaa gcc atc acc aac atc gcg gca gcc aat atc ggc gac atc ggc 2208 Gly Glu Ala Ile Thr Asn Ile Ala Ala Ala Asn Ile Gly Asp Ile Gly 725 730 735 aac atc aaa ctc tcc gcc aac tgg atg gcg gcg tgc ggc aac gaa ggc 2256 Asn Ile Lys Leu Ser Ala Asn Trp Met Ala Ala Cys Gly Asn Glu Gly 740 745 750 gaa gac gaa aaa ctc tac cgc acc gtc gaa gcg gtt tcc aaa gcc tgt 2304 Glu Asp Glu Lys Leu Tyr Arg Thr Val Glu Ala Val Ser Lys Ala Cys 755 760 765 cag gca ttg gat ttg agc att ccc gtg ggc aaa gac agc ctg tcg atg 2352 Gln Ala Leu Asp Leu Ser Ile Pro Val Gly Lys Asp Ser Leu Ser Met 770 775 780 aaa acc gtg tgg cag gac ggc gaa gag aaa aaa tcc gtc gtt tcg ccg 2400 Lys Thr Val Trp Gln Asp Gly Glu Glu Lys Lys Ser Val Val Ser Pro 785 790 795 800 ttg agc ctg att atc tcc gcg ttc gcg ccg gtt caa gac gta cgc aaa 2448 Leu Ser Leu Ile Ile Ser Ala Phe Ala Pro Val Gln Asp Val Arg Lys 805 810 815 acc gtt acg ccc gaa ttg aaa aac gtc gag gac agc gta ttg ctg ttt 2496 Thr Val Thr Pro Glu Leu Lys Asn Val Glu Asp Ser Val Leu Leu Phe 820 825 830 gtc gat ttg ggc ttc ggc aaa gcg cgt atg ggc ggc tcg gcg ttt ggt 2544 Val Asp Leu Gly Phe Gly Lys Ala Arg Met Gly Gly Ser Ala Phe Gly 835 840 845 cag gtg tac aac aat atg agc ggc gac gcg ccc gat ttg gac gat aca 2592 Gln Val Tyr Asn Asn Met Ser Gly Asp Ala Pro Asp Leu Asp Asp Thr 850 855 860 agt cgt ctg aaa gcg ttt tac aac gtg att cag cag ctt gtc gcc gaa 2640 Ser Arg Leu Lys Ala Phe Tyr Asn Val Ile Gln Gln Leu Val Ala Glu 865 870 875 880 gac aaa ctc ttg gcg tat cac gac cgc agc gac ggc ggc ttg ttt gcc 2688 Asp Lys Leu Leu Ala Tyr His Asp Arg Ser Asp Gly Gly Leu Phe Ala 885 890 895 gtt ttg gta gaa atg gcg ttt gca ggg cgg tgc ggc ttg gat ata gat 2736 Val Leu Val Glu Met Ala Phe Ala Gly Arg Cys Gly Leu Asp Ile Asp 900 905 910 tta aat tta ttg ctt gca caa aca ttt att acc aac cat acc gct ctg 2784 Leu Asn Leu Leu Leu Ala Gln Thr Phe Ile Thr Asn His Thr Ala Leu 915 920 925 tct caa tca ttg cgg act gaa gag gta aaa gcg ttg gct gaa tgg caa 2832 Ser Gln Ser Leu Arg Thr Glu Glu Val Lys Ala Leu Ala Glu Trp Gln 930 935 940 gaa acc att gcc cgc aca tta ttt aat gaa gag ttg ggt gct gtt atc 2880 Glu Thr Ile Ala Arg Thr Leu Phe Asn Glu Glu Leu Gly Ala Val Ile 945 950 955 960 caa gtt aga aaa caa gat gtt gcc gat att atc aat tta ttc tat caa 2928 Gln Val Arg Lys Gln Asp Val Ala Asp Ile Ile Asn Leu Phe Tyr Gln 965 970 975 caa cag ctg cat cat aat gtc ttt gaa atc ggt acg tta act gat gag 2976 Gln Gln Leu His His Asn Val Phe Glu Ile Gly Thr Leu Thr Asp Glu 980 985 990 aac acg tta atc atc cgc gac ggg caa acg cac ctt att tct gac aac 3024 Asn Thr Leu Ile Ile Arg Asp Gly Gln Thr His Leu Ile Ser Asp Asn 995 1000 1005 cta atc aaa ctg caa caa acc tgg caa gaa acc agc cat caa atc caa 3072 Leu Ile Lys Leu Gln Gln Thr Trp Gln Glu Thr Ser His Gln Ile Gln 1010 1015 1020 cgc ctg cgc gac aac cct gcc tgc gcc gac agc gag ttt gcc ctg att 3120 Arg Leu Arg Asp Asn Pro Ala Cys Ala Asp Ser Glu Phe Ala Leu Ile 1025 1030 1035 1040 ggc gac aac gga cgc agc gca ttg ttt gcc aac ctg aaa ttc gac gtg 3168 Gly Asp Asn Gly Arg Ser Ala Leu Phe Ala Asn Leu Lys Phe Asp Val 1045 1050 1055 aac gaa gac atc gcc gcg ccg ttt atc aac agc ggc gcg aaa ccc aaa 3216 Asn Glu Asp Ile Ala Ala Pro Phe Ile Asn Ser Gly Ala Lys Pro Lys 1060 1065 1070 atc gcc atc ctg cgc gaa cag ggc gta aac ggg caa atc gaa atg gcc 3264 Ile Ala Ile Leu Arg Glu Gln Gly Val Asn Gly Gln Ile Glu Met Ala 1075 1080 1085 gcc gcc ttc acc cgt gcc ggt ttc gat gcc tac gac gtg cat atg tcc 3312 Ala Ala Phe Thr Arg Ala Gly Phe Asp Ala Tyr Asp Val His Met Ser 1090 1095 1100 gac ctg atg gca ggc cgc gtc cac ctt gcc gac ttc aaa atg ctg gcg 3360 Asp Leu Met Ala Gly Arg Val His Leu Ala Asp Phe Lys Met Leu Ala 1105 1110 1115 1120 gcg tgc ggc ggc ttc agc tac ggc gac gta ctc ggc gcg ggc aaa ggc 3408 Ala Cys Gly Gly Phe Ser Tyr Gly Asp Val Leu Gly Ala Gly Lys Gly 1125 1130 1135 tgg gcg aaa tcc atc ctg ttc cac ccc gcc tta cgc gac cag ttc gcc 3456 Trp Ala Lys Ser Ile Leu Phe His Pro Ala Leu Arg Asp Gln Phe Ala 1140 1145 1150 gcc ttc ttc acc gac ccg aac acg ctg aca ttg ggc gtg tgc aac ggc 3504 Ala Phe Phe Thr Asp Pro Asn Thr Leu Thr Leu Gly Val Cys Asn Gly 1155 1160 1165 tgc cag atg gtc agc aac ctc gcc gaa atc atc ccc ggc acg gca ggc 3552 Cys Gln Met Val Ser Asn Leu Ala Glu Ile Ile Pro Gly Thr Ala Gly 1170 1175 1180 tgg ccg aag ttc aag cgc aac ctg agc gaa cag ttc gaa gcg cgc ctg 3600 Trp Pro Lys Phe Lys Arg Asn Leu Ser Glu Gln Phe Glu Ala Arg Leu 1185 1190 1195 1200 agc atg gtt cac gtc ccc aaa tca gcc tcc ctg att ctg aac gaa atg 3648 Ser Met Val His Val Pro Lys Ser Ala Ser Leu Ile Leu Asn Glu Met 1205 1210 1215 caa ggc tcc agc ctg ccc gtc gtc gtc agc cac ggc gaa ggc cgc gcc 3696 Gln Gly Ser Ser Leu Pro Val Val Val Ser His Gly Glu Gly Arg Ala 1220 1225 1230 gac ttc gcg ctt cac ggc ggc aac att tct gcc gat ttg ggc att gcg 3744 Asp Phe Ala Leu His Gly Gly Asn Ile Ser Ala Asp Leu Gly Ile Ala 1235 1240 1245 ttg caa tat gtg gac gga caa aac caa att acc caa acc tac ccg ctc 3792 Leu Gln Tyr Val Asp Gly Gln Asn Gln Ile Thr Gln Thr Tyr Pro Leu 1250 1255 1260 aac ccc aac ggc tcg ccg caa ggc atc gcc ggc gtg acc aac gcc gac 3840 Asn Pro Asn Gly Ser Pro Gln Gly Ile Ala Gly Val Thr Asn Ala Asp 1265 1270 1275 1280 ggc cgc gtt acc atc atg atg ccg cat cct gaa cgt gta tac cgc gcc 3888 Gly Arg Val Thr Ile Met Met Pro His Pro Glu Arg Val Tyr Arg Ala 1285 1290 1295 gca caa atg agc tgg aaa ccg gaa gac tgg acg gaa ttg tcc ggc tgg 3936 Ala Gln Met Ser Trp Lys Pro Glu Asp Trp Thr Glu Leu Ser Gly Trp 1300 1305 1310 tac cgc ctc ttc gcc ggc gca cgt aaa gcc ttg ggc 3972 Tyr Arg Leu Phe Ala Gly Ala Arg Lys Ala Leu Gly 1315 1320 <210> 38 <211> 1324 <212> PRT <213> Neisseria meningitidis <400> 38 Val Ser Arg Ile Met Ser Val Val Leu Pro Leu Arg Gly Val Thr Ala 1 5 10 15 Leu Ser Asp Phe Arg Val Glu Lys Leu Leu Gln Lys Ala Ala Ala Leu 20 25 30 Gly Leu Pro Glu Val Lys Leu Ser Ser Glu Phe Trp Tyr Phe Val Gly 35 40 45 Ser Glu Lys Ala Leu Asp Ala Ala Thr Val Glu Lys Leu Gln Ala Leu 50 55 60 Leu Ala Ala Gln Ser Val Glu Gln Thr Pro Lys Ala Arg Glu Gly Leu 65 70 75 80 His Leu Phe Leu Val Thr Pro Arg Leu Gly Thr Ile Ser Pro Trp Ala 85 90 95 Ser Lys Ala Thr Asn Ile Ala Glu Asn Cys Gly Leu Ala Gly Ile Glu 100 105 110 Arg Ile Glu Arg Gly Met Ala Val Trp Leu Glu Gly Ala Leu Thr Asp 115 120 125 Glu Gln Gln Gln Gln Trp Ala Ala Leu Leu His Asp Arg Met Thr Glu 130 135 140 Ser Val Leu Pro Asp Phe Gln Thr Ala Ser Lys Leu Phe His His Leu 145 150 155 160 Glu Ser Glu Thr Phe Ser Thr Val Asp Val Leu Gly Gly Gly Lys Glu 165 170 175 Ala Leu Val Lys Ala Asn Thr Glu Met Gly Leu Ala Leu Ser Ala Asp 180 185 190 Glu Ile Asp Tyr Leu Val Glu Asn Tyr Gln Ala Leu Gln Arg Asn Pro 195 200 205 Ser Asp Val Glu Leu Met Met Phe Ala Gln Ala Asn Ser Glu His Cys 210 215 220 Arg His Lys Ile Phe Asn Ala Asp Phe Ile Leu Asn Gly Glu Lys Gln 225 230 235 240 Pro Lys Ser Leu Phe Gly Met Ile Arg Asp Thr His Asn Ala His Pro 245 250 255 Glu Gly Thr Val Val Ala Tyr Lys Asp Asn Ser Ser Val Ile Glu Gly 260 265 270 Ala Lys Val Glu Arg Phe Tyr Pro Asn Ala Ala Glu Asn Gln Gly Tyr 275 280 285 Arg Phe His Glu Glu Asp Thr His Ile Ile Met Lys Val Glu Thr His 290 295 300 Asn His Pro Thr Ala Ile Ala Pro Phe Ala Gly Ala Ala Thr Gly Ala 305 310 315 320 Gly Gly Glu Ile Arg Asp Glu Gly Ala Thr Gly Lys Gly Ser Arg Pro 325 330 335 Lys Ala Gly Leu Thr Gly Phe Thr Val Ser Asn Leu Asn Ile Pro Gly 340 345 350 Leu Lys Gln Pro Trp Glu Gln Asp Tyr Gly Lys Pro Glu His Ile Ser 355 360 365 Ser Pro Leu Asp Ile Met Ile Glu Gly Pro Ile Gly Gly Ala Ala Phe 370 375 380 Asn Asn Glu Phe Gly Arg Pro Asn Leu Leu Gly Tyr Phe Arg Thr Phe 385 390 395 400 Glu Glu Lys Phe Asp Gly Gln Val Arg Gly Tyr His Lys Pro Ile Met 405 410 415 Ile Ala Gly Gly Leu Gly Ser Ile Gln Ala Gln Gln Thr His Lys Asp 420 425 430 Glu Ile Pro Glu Gly Ala Leu Leu Ile Gln Leu Gly Gly Pro Gly Met 435 440 445 Leu Ile Gly Leu Gly Gly Gly Ala Ala Ser Ser Met Asp Thr Gly Thr 450 455 460 Asn Asp Ala Ser Leu Asp Phe Asn Ser Val Gln Arg Gly Asn Pro Glu 465 470 475 480 Ile Glu Arg Arg Ala Gln Glu Val Ile Asp Arg Cys Trp Gln Leu Gly 485 490 495 Asp Lys Asn Pro Ile Ile Ser Ile His Asp Val Gly Ala Gly Gly Leu 500 505 510 Ser Asn Ala Phe Pro Glu Leu Val Asn Asp Ala Gly Arg Gly Ala Val 515 520 525 Phe Lys Leu Arg Glu Val Pro Leu Glu Glu His Gly Leu Asn Pro Leu 530 535 540 Gln Ile Trp Cys Asn Glu Ser Gln Glu Arg Tyr Val Leu Ser Ile Leu 545 550 555 560 Glu Lys Asp Leu Asp Ile Phe Arg Ser Ile Cys Glu Arg Glu Arg Cys 565 570 575 Pro Phe Ala Val Val Gly Thr Ala Thr Asp Asp Gly His Leu Lys Val 580 585 590 Arg Asp Asp Leu Phe Ser Asn Asn Pro Val Asp Leu Pro Leu Asn Val 595 600 605 Leu Leu Gly Lys Pro Pro Lys Thr Thr Arg Thr Asp Lys Thr Val Ala 610 615 620 Pro Ser Lys Lys Pro Phe His Ala Gly Asp Ile Asp Ile Thr Glu Ala 625 630 635 640 Ala Tyr Arg Val Leu Arg Leu Pro Ala Val Ala Ala Lys Asn Phe Leu 645 650 655 Ile Thr Ile Gly Asp Arg Ser Val Gly Gly Met Thr His Arg Asp Gln 660 665 670 Met Val Gly Lys Tyr Gln Thr Pro Val Ala Asp Cys Ala Val Thr Met 675 680 685 Met Gly Phe Asn Thr Tyr Arg Gly Glu Ala Met Ser Met Gly Glu Lys 690 695 700 Pro Thr Val Ala Leu Phe Asp Ala Pro Ala Ser Gly Arg Met Cys Val 705 710 715 720 Gly Glu Ala Ile Thr Asn Ile Ala Ala Ala Asn Ile Gly Asp Ile Gly 725 730 735 Asn Ile Lys Leu Ser Ala Asn Trp Met Ala Ala Cys Gly Asn Glu Gly 740 745 750 Glu Asp Glu Lys Leu Tyr Arg Thr Val Glu Ala Val Ser Lys Ala Cys 755 760 765 Gln Ala Leu Asp Leu Ser Ile Pro Val Gly Lys Asp Ser Leu Ser Met 770 775 780 Lys Thr Val Trp Gln Asp Gly Glu Glu Lys Lys Ser Val Val Ser Pro 785 790 795 800 Leu Ser Leu Ile Ile Ser Ala Phe Ala Pro Val Gln Asp Val Arg Lys 805 810 815 Thr Val Thr Pro Glu Leu Lys Asn Val Glu Asp Ser Val Leu Leu Phe 820 825 830 Val Asp Leu Gly Phe Gly Lys Ala Arg Met Gly Gly Ser Ala Phe Gly 835 840 845 Gln Val Tyr Asn Asn Met Ser Gly Asp Ala Pro Asp Leu Asp Asp Thr 850 855 860 Ser Arg Leu Lys Ala Phe Tyr Asn Val Ile Gln Gln Leu Val Ala Glu 865 870 875 880 Asp Lys Leu Leu Ala Tyr His Asp Arg Ser Asp Gly Gly Leu Phe Ala 885 890 895 Val Leu Val Glu Met Ala Phe Ala Gly Arg Cys Gly Leu Asp Ile Asp 900 905 910 Leu Asn Leu Leu Leu Ala Gln Thr Phe Ile Thr Asn His Thr Ala Leu 915 920 925 Ser Gln Ser Leu Arg Thr Glu Glu Val Lys Ala Leu Ala Glu Trp Gln 930 935 940 Glu Thr Ile Ala Arg Thr Leu Phe Asn Glu Glu Leu Gly Ala Val Ile 945 950 955 960 Gln Val Arg Lys Gln Asp Val Ala Asp Ile Ile Asn Leu Phe Tyr Gln 965 970 975 Gln Gln Leu His His Asn Val Phe Glu Ile Gly Thr Leu Thr Asp Glu 980 985 990 Asn Thr Leu Ile Ile Arg Asp Gly Gln Thr His Leu Ile Ser Asp Asn 995 1000 1005 Leu Ile Lys Leu Gln Gln Thr Trp Gln Glu Thr Ser His Gln Ile Gln 1010 1015 1020 Arg Leu Arg Asp Asn Pro Ala Cys Ala Asp Ser Glu Phe Ala Leu Ile 025 1030 1035 1040 Gly Asp Asn Gly Arg Ser Ala Leu Phe Ala Asn Leu Lys Phe Asp Val 1045 1050 1055 Asn Glu Asp Ile Ala Ala Pro Phe Ile Asn Ser Gly Ala Lys Pro Lys 1060 1065 1070 Ile Ala Ile Leu Arg Glu Gln Gly Val Asn Gly Gln Ile Glu Met Ala 1075 1080 1085 Ala Ala Phe Thr Arg Ala Gly Phe Asp Ala Tyr Asp Val His Met Ser 1090 1095 1100 Asp Leu Met Ala Gly Arg Val His Leu Ala Asp Phe Lys Met Leu Ala 105 1110 1115 1120 Ala Cys Gly Gly Phe Ser Tyr Gly Asp Val Leu Gly Ala Gly Lys Gly 1125 1130 1135 Trp Ala Lys Ser Ile Leu Phe His Pro Ala Leu Arg Asp Gln Phe Ala 1140 1145 1150 Ala Phe Phe Thr Asp Pro Asn Thr Leu Thr Leu Gly Val Cys Asn Gly 1155 1160 1165 Cys Gln Met Val Ser Asn Leu Ala Glu Ile Ile Pro Gly Thr Ala Gly 1170 1175 1180 Trp Pro Lys Phe Lys Arg Asn Leu Ser Glu Gln Phe Glu Ala Arg Leu 185 1190 1195 1200 Ser Met Val His Val Pro Lys Ser Ala Ser Leu Ile Leu Asn Glu Met 1205 1210 1215 Gln Gly Ser Ser Leu Pro Val Val Val Ser His Gly Glu Gly Arg Ala 1220 1225 1230 Asp Phe Ala Leu His Gly Gly Asn Ile Ser Ala Asp Leu Gly Ile Ala 1235 1240 1245 Leu Gln Tyr Val Asp Gly Gln Asn Gln Ile Thr Gln Thr Tyr Pro Leu 1250 1255 1260 Asn Pro Asn Gly Ser Pro Gln Gly Ile Ala Gly Val Thr Asn Ala Asp 265 1270 1275 1280 Gly Arg Val Thr Ile Met Met Pro His Pro Glu Arg Val Tyr Arg Ala 1285 1290 1295 Ala Gln Met Ser Trp Lys Pro Glu Asp Trp Thr Glu Leu Ser Gly Trp 1300 1305 1310 Tyr Arg Leu Phe Ala Gly Ala Arg Lys Ala Leu Gly 1315 1320 <210> 39 <211> 471 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(471) <400> 39 atg tcc cgc aat acc gaa gag ctg caa ggc atc tcg ctt ttg ggt aat 48 Met Ser Arg Asn Thr Glu Glu Leu Gln Gly Ile Ser Leu Leu Gly Asn 1 5 10 15 cag aaa acc cga tat ccg acc ggc tac gcg cct gaa att ctc gaa gca 96 Gln Lys Thr Arg Tyr Pro Thr Gly Tyr Ala Pro Glu Ile Leu Glu Ala 20 25 30 ttc gac aac aaa cat ccc gac aac gac tat ttc gtc aaa ttc gtc tgc 144 Phe Asp Asn Lys His Pro Asp Asn Asp Tyr Phe Val Lys Phe Val Cys 35 40 45 cca gag ttc acc agc ctc tgc ccc atg acc ggg cag ccc gac ttc gcc 192 Pro Glu Phe Thr Ser Leu Cys Pro Met Thr Gly Gln Pro Asp Phe Ala 50 55 60 acc atc tac atc cgc tac att ccg cac atc aaa atg gtg gaa agc aaa 240 Thr Ile Tyr Ile Arg Tyr Ile Pro His Ile Lys Met Val Glu Ser Lys 65 70 75 80 tcc ctg aaa ctc tac ctc ttc agc ttc cgc aac cac ggc gat ttt cat 288 Ser Leu Lys Leu Tyr Leu Phe Ser Phe Arg Asn His Gly Asp Phe His 85 90 95 gaa gac tgc gtc aac atc atc atg aaa gac ctc att gcc ctg atg gat 336 Glu Asp Cys Val Asn Ile Ile Met Lys Asp Leu Ile Ala Leu Met Asp 100 105 110 ccg aaa tac atc gaa gta ttc ggc gag ttc aca ccg cgc ggc ggc atc 384 Pro Lys Tyr Ile Glu Val Phe Gly Glu Phe Thr Pro Arg Gly Gly Ile 115 120 125 gcc att cat cct ttc gcc aat tac ggc aaa gca ggc acc gag ttt gaa 432 Ala Ile His Pro Phe Ala Asn Tyr Gly Lys Ala Gly Thr Glu Phe Glu 130 135 140 gca ttg gcg cgt aaa cgc ctg ttt gag cac gac gca caa 471 Ala Leu Ala Arg Lys Arg Leu Phe Glu His Asp Ala Gln 145 150 155 <210> 40 <211> 157 <212> PRT <213> Neisseria meningitidis <400> 40 Met Ser Arg Asn Thr Glu Glu Leu Gln Gly Ile Ser Leu Leu Gly Asn 1 5 10 15 Gln Lys Thr Arg Tyr Pro Thr Gly Tyr Ala Pro Glu Ile Leu Glu Ala 20 25 30 Phe Asp Asn Lys His Pro Asp Asn Asp Tyr Phe Val Lys Phe Val Cys 35 40 45 Pro Glu Phe Thr Ser Leu Cys Pro Met Thr Gly Gln Pro Asp Phe Ala 50 55 60 Thr Ile Tyr Ile Arg Tyr Ile Pro His Ile Lys Met Val Glu Ser Lys 65 70 75 80 Ser Leu Lys Leu Tyr Leu Phe Ser Phe Arg Asn His Gly Asp Phe His 85 90 95 Glu Asp Cys Val Asn Ile Ile Met Lys Asp Leu Ile Ala Leu Met Asp 100 105 110 Pro Lys Tyr Ile Glu Val Phe Gly Glu Phe Thr Pro Arg Gly Gly Ile 115 120 125 Ala Ile His Pro Phe Ala Asn Tyr Gly Lys Ala Gly Thr Glu Phe Glu 130 135 140 Ala Leu Ala Arg Lys Arg Leu Phe Glu His Asp Ala Gln 145 150 155 <210> 41 <211> 504 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(504) <400> 41 atg ccc cta cta gac agt ttc aaa gtc gat cac acc cgt atg cat gcc 48 Met Pro Leu Leu Asp Ser Phe Lys Val Asp His Thr Arg Met His Ala 1 5 10 15 ccc gcc gta cgc gtg gcg aaa acc atg acc acg ccc aaa ggc gac acc 96 Pro Ala Val Arg Val Ala Lys Thr Met Thr Thr Pro Lys Gly Asp Thr 20 25 30 att acc gtg ttc gac ctg cgc ttt tgc gtt ccc aat aaa gaa atc ctg 144 Ile Thr Val Phe Asp Leu Arg Phe Cys Val Pro Asn Lys Glu Ile Leu 35 40 45 cct gaa aaa ggc ata cac acg ctg gag cat ttg ttc gca ggt ttt atg 192 Pro Glu Lys Gly Ile His Thr Leu Glu His Leu Phe Ala Gly Phe Met 50 55 60 cgc gac cac ttg aac ggc aac ggc gtg gaa atc atc gac att tcc ccg 240 Arg Asp His Leu Asn Gly Asn Gly Val Glu Ile Ile Asp Ile Ser Pro 65 70 75 80 atg ggc tgc cgc acc ggt ttt tat atg agc ctt atc ggc acg cct tcc 288 Met Gly Cys Arg Thr Gly Phe Tyr Met Ser Leu Ile Gly Thr Pro Ser 85 90 95 gaa cag cag gtc gcc gat gcg tgg ctg gct tcg atg cag gat gtt ttg 336 Glu Gln Gln Val Ala Asp Ala Trp Leu Ala Ser Met Gln Asp Val Leu 100 105 110 aat gtc aaa gac caa agc aaa atc ccc gag ttg aac gaa tac caa tgc 384 Asn Val Lys Asp Gln Ser Lys Ile Pro Glu Leu Asn Glu Tyr Gln Cys 115 120 125 ggc act tat caa atg cac tcg ctc gcc gaa gcg cag caa atc gcg caa 432 Gly Thr Tyr Gln Met His Ser Leu Ala Glu Ala Gln Gln Ile Ala Gln 130 135 140 aac gtg ttg gcg cgc aaa gtg gcg gtg aac aaa aat gaa gag ctg acg 480 Asn Val Leu Ala Arg Lys Val Ala Val Asn Lys Asn Glu Glu Leu Thr 145 150 155 160 ctg gat gaa ggg ctg ctg aac gcc 504 Leu Asp Glu Gly Leu Leu Asn Ala 165 <210> 42 <211> 168 <212> PRT <213> Neisseria meningitidis <400> 42 Met Pro Leu Leu Asp Ser Phe Lys Val Asp His Thr Arg Met His Ala 1 5 10 15 Pro Ala Val Arg Val Ala Lys Thr Met Thr Thr Pro Lys Gly Asp Thr 20 25 30 Ile Thr Val Phe Asp Leu Arg Phe Cys Val Pro Asn Lys Glu Ile Leu 35 40 45 Pro Glu Lys Gly Ile His Thr Leu Glu His Leu Phe Ala Gly Phe Met 50 55 60 Arg Asp His Leu Asn Gly Asn Gly Val Glu Ile Ile Asp Ile Ser Pro 65 70 75 80 Met Gly Cys Arg Thr Gly Phe Tyr Met Ser Leu Ile Gly Thr Pro Ser 85 90 95 Glu Gln Gln Val Ala Asp Ala Trp Leu Ala Ser Met Gln Asp Val Leu 100 105 110 Asn Val Lys Asp Gln Ser Lys Ile Pro Glu Leu Asn Glu Tyr Gln Cys 115 120 125 Gly Thr Tyr Gln Met His Ser Leu Ala Glu Ala Gln Gln Ile Ala Gln 130 135 140 Asn Val Leu Ala Arg Lys Val Ala Val Asn Lys Asn Glu Glu Leu Thr 145 150 155 160 Leu Asp Glu Gly Leu Leu Asn Ala 165 <210> 43 <211> 813 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(813) <400> 43 atg act atg cac gcc ctc ccc cgc tac gcc gtt ttt ggc aac ccc gtc 48 Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val 1 5 10 15 gcc cac agc aaa tcg ccg caa att cat caa caa ttt gcc ctt cag gaa 96 Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu 20 25 30 ggc gtt gac att gaa tac gaa cgc att tgc gcc gac atc ggc ggt ttc 144 Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe 35 40 45 gcg cag gcg gtt tcg aca ttt ttt gaa aca ggc ggt tgc ggg gca aac 192 Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn 50 55 60 gtt acc gta ccg ttc aag cag gaa gcg ttt cat ctg gcg gac gag cat 240 Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His 65 70 75 80 tct gaa cgc gca ttg gct gcc ggc gcg gtc aac acg ctg att ttt ctg 288 Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu 85 90 95 aaa aac gga aaa ctg cgc ggc gac aat acc gac ggt atc ggt ttg gcc 336 Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala 100 105 110 aac gac atc acg cag gtc aaa aac att gcc atc gaa ggc aaa acc atc 384 Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile 115 120 125 ttg ctt ttg ggc gcg ggc ggc gcg gtg cgc ggc gtg att cct gtt ttg 432 Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu 130 135 140 aaa gaa cac cgt cct gcc cgt atc gtc att gcc aac cgt acc cgc gcc 480 Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala 145 150 155 160 aaa gcc gag gaa ttg gcg cag ctt ttc ggc att gaa gcc gtc ccg atg 528 Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met 165 170 175 gcg gat gtg aac ggc ggt ttt gat atc atc atc aac ggc acg tcg ggc 576 Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly 180 185 190 ggt cta aac ggt cag att ccc gat att ccg ccc gat att ttt caa aac 624 Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn 195 200 205 tgc gcg ctt gcc tac gat atg gtg tac ggc tgc gcg gca aaa ccg ttt 672 Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe 210 215 220 tta gat ttt gca cga caa tcg ggt gcg aaa aaa act gcc gac gga ctg 720 Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu 225 230 235 240 ggt atg cta gtc ggt caa gcg gcg gct tcc tac gcc ctc tgg cgc gga 768 Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly 245 250 255 ttt acg ccc gat atc cgc ccc gtt atc gaa tac atg aaa gcc cta 813 Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala Leu 260 265 270 <210> 44 <211> 271 <212> PRT <213> Neisseria meningitidis <400> 44 Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val 1 5 10 15 Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu 20 25 30 Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe 35 40 45 Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn 50 55 60 Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His 65 70 75 80 Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu 85 90 95 Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala 100 105 110 Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile 115 120 125 Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu 130 135 140 Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala 145 150 155 160 Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met 165 170 175 Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly 180 185 190 Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn 195 200 205 Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe 210 215 220 Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu 225 230 235 240 Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly 245 250 255 Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala Leu 260 265 270 <210> 45 <211> 546 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(546) <400> 45 ttg ctt tct cat ttg gat atg aaa ttc gtc agc gac ctt ttg tct gtc 48 Leu Leu Ser His Leu Asp Met Lys Phe Val Ser Asp Leu Leu Ser Val 1 5 10 15 atc ttg ttt ttt gct act tat acc gtt acc aaa aat atg att gcc gct 96 Ile Leu Phe Phe Ala Thr Tyr Thr Val Thr Lys Asn Met Ile Ala Ala 20 25 30 acg gcg gtt gcc ttg gtt gcc ggt gtg gtt cag gcg gct ttt ctg tat 144 Thr Ala Val Ala Leu Val Ala Gly Val Val Gln Ala Ala Phe Leu Tyr 35 40 45 tgg aaa tat aaa aag ctg gat acg atg cag tgg gtc gga ctg gtg ctg 192 Trp Lys Tyr Lys Lys Leu Asp Thr Met Gln Trp Val Gly Leu Val Leu 50 55 60 att gtc gta ttc ggc ggc gca acc att gtt ttg ggc gac agc cgc ttc 240 Ile Val Val Phe Gly Gly Ala Thr Ile Val Leu Gly Asp Ser Arg Phe 65 70 75 80 att atg tgg aag ccg agc gtt ttg ttt tgg ctg ggc gcg ctg ttc ctg 288 Ile Met Trp Lys Pro Ser Val Leu Phe Trp Leu Gly Ala Leu Phe Leu 85 90 95 tgg ggc agc cac ctc gcc ggt aaa aac ggc ttg aag gcg agt atc ggc 336 Trp Gly Ser His Leu Ala Gly Lys Asn Gly Leu Lys Ala Ser Ile Gly 100 105 110 agg gag att cag ctt ccg gat gcc gta tgg gcg aaa ttg acg tat atg 384 Arg Glu Ile Gln Leu Pro Asp Ala Val Trp Ala Lys Leu Thr Tyr Met 115 120 125 tgg gtc ggt ttc ctg att ttt atg ggt atc gcc aac tgg ttt gtg ttt 432 Trp Val Gly Phe Leu Ile Phe Met Gly Ile Ala Asn Trp Phe Val Phe 130 135 140 acc cgg ttc gag tcg caa tgg gtc aac tat aaa atg ttc ggc tcg act 480 Thr Arg Phe Glu Ser Gln Trp Val Asn Tyr Lys Met Phe Gly Ser Thr 145 150 155 160 gca ctg atg ctt gtt ttc ttt att att cag ggt att tat ctg agt acc 528 Ala Leu Met Leu Val Phe Phe Ile Ile Gln Gly Ile Tyr Leu Ser Thr 165 170 175 tgt ctg aaa aag gag gat 546 Cys Leu Lys Lys Glu Asp 180 <210> 46 <211> 182 <212> PRT <213> Neisseria meningitidis <400> 46 Leu Leu Ser His Leu Asp Met Lys Phe Val Ser Asp Leu Leu Ser Val 1 5 10 15 Ile Leu Phe Phe Ala Thr Tyr Thr Val Thr Lys Asn Met Ile Ala Ala 20 25 30 Thr Ala Val Ala Leu Val Ala Gly Val Val Gln Ala Ala Phe Leu Tyr 35 40 45 Trp Lys Tyr Lys Lys Leu Asp Thr Met Gln Trp Val Gly Leu Val Leu 50 55 60 Ile Val Val Phe Gly Gly Ala Thr Ile Val Leu Gly Asp Ser Arg Phe 65 70 75 80 Ile Met Trp Lys Pro Ser Val Leu Phe Trp Leu Gly Ala Leu Phe Leu 85 90 95 Trp Gly Ser His Leu Ala Gly Lys Asn Gly Leu Lys Ala Ser Ile Gly 100 105 110 Arg Glu Ile Gln Leu Pro Asp Ala Val Trp Ala Lys Leu Thr Tyr Met 115 120 125 Trp Val Gly Phe Leu Ile Phe Met Gly Ile Ala Asn Trp Phe Val Phe 130 135 140 Thr Arg Phe Glu Ser Gln Trp Val Asn Tyr Lys Met Phe Gly Ser Thr 145 150 155 160 Ala Leu Met Leu Val Phe Phe Ile Ile Gln Gly Ile Tyr Leu Ser Thr 165 170 175 Cys Leu Lys Lys Glu Asp 180 <210> 47 <211> 585 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(585) <400> 47 ttg aat att aaa ctg aaa acc ttg tta ttg ccc ttc gcc acg ctg gca 48 Leu Asn Ile Lys Leu Lys Thr Leu Leu Leu Pro Phe Ala Thr Leu Ala 1 5 10 15 ttg tgc acc aat gct ttt gcc gcc ccg ccc agc gac gcg tcg ttg gcg 96 Leu Cys Thr Asn Ala Phe Ala Ala Pro Pro Ser Asp Ala Ser Leu Ala 20 25 30 cgt tgg ctg gat acg cag aat ttt gac cgg gat ata gaa aaa aat atg 144 Arg Trp Leu Asp Thr Gln Asn Phe Asp Arg Asp Ile Glu Lys Asn Met 35 40 45 att gag ggc ttt aat gcc gga ttt aaa ccg tat gcg gac aaa gcc ctt 192 Ile Glu Gly Phe Asn Ala Gly Phe Lys Pro Tyr Ala Asp Lys Ala Leu 50 55 60 gcc gaa atg ccg gaa gcg aaa aaa gat cag gcg gca gaa gcc ttt aac 240 Ala Glu Met Pro Glu Ala Lys Lys Asp Gln Ala Ala Glu Ala Phe Asn 65 70 75 80 cgt tat cgt gag aat gtt ttg aaa gat ttg att acg ccc gaa gtg aaa 288 Arg Tyr Arg Glu Asn Val Leu Lys Asp Leu Ile Thr Pro Glu Val Lys 85 90 95 cag gct gtc cgc aat act tta ttg aag aat gcc cgt gag ata tac acg 336 Gln Ala Val Arg Asn Thr Leu Leu Lys Asn Ala Arg Glu Ile Tyr Thr 100 105 110 caa gaa gaa att gac ggc atg att gcc ttt tac ggt tcg cct gtc ggt 384 Gln Glu Glu Ile Asp Gly Met Ile Ala Phe Tyr Gly Ser Pro Val Gly 115 120 125 cag tcc gtc gtt gcc aaa aat ccg cgc tta atc aag aaa tcg atg agt 432 Gln Ser Val Val Ala Lys Asn Pro Arg Leu Ile Lys Lys Ser Met Ser 130 135 140 gaa ata gcg gta tct tgg act gca ttg tca ggg aaa atc gcg caa cat 480 Glu Ile Ala Val Ser Trp Thr Ala Leu Ser Gly Lys Ile Ala Gln His 145 150 155 160 cat ctg ccc gag ttt acg gaa gag ttg cgg cgc atc atc tgc ggc ggt 528 His Leu Pro Glu Phe Thr Glu Glu Leu Arg Arg Ile Ile Cys Gly Gly 165 170 175 aaa aat ccc gat gcg ggc tgt aaa caa gcc gga cag gtt ggg aaa agg 576 Lys Asn Pro Asp Ala Gly Cys Lys Gln Ala Gly Gln Val Gly Lys Arg 180 185 190 cat cag aaa 585 His Gln Lys 195 <210> 48 <211> 195 <212> PRT <213> Neisseria meningitidis <400> 48 Leu Asn Ile Lys Leu Lys Thr Leu Leu Leu Pro Phe Ala Thr Leu Ala 1 5 10 15 Leu Cys Thr Asn Ala Phe Ala Ala Pro Pro Ser Asp Ala Ser Leu Ala 20 25 30 Arg Trp Leu Asp Thr Gln Asn Phe Asp Arg Asp Ile Glu Lys Asn Met 35 40 45 Ile Glu Gly Phe Asn Ala Gly Phe Lys Pro Tyr Ala Asp Lys Ala Leu 50 55 60 Ala Glu Met Pro Glu Ala Lys Lys Asp Gln Ala Ala Glu Ala Phe Asn 65 70 75 80 Arg Tyr Arg Glu Asn Val Leu Lys Asp Leu Ile Thr Pro Glu Val Lys 85 90 95 Gln Ala Val Arg Asn Thr Leu Leu Lys Asn Ala Arg Glu Ile Tyr Thr 100 105 110 Gln Glu Glu Ile Asp Gly Met Ile Ala Phe Tyr Gly Ser Pro Val Gly 115 120 125 Gln Ser Val Val Ala Lys Asn Pro Arg Leu Ile Lys Lys Ser Met Ser 130 135 140 Glu Ile Ala Val Ser Trp Thr Ala Leu Ser Gly Lys Ile Ala Gln His 145 150 155 160 His Leu Pro Glu Phe Thr Glu Glu Leu Arg Arg Ile Ile Cys Gly Gly 165 170 175 Lys Asn Pro Asp Ala Gly Cys Lys Gln Ala Gly Gln Val Gly Lys Arg 180 185 190 His Gln Lys 195 <210> 49 <211> 462 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(462) <400> 49 ttg ctt tgc ccg gaa aaa atg tcg ggg atg gcg gga cag tat ccg tac 48 Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr 1 5 10 15 ggc gtc cgg tcg ggt ttg cgg agg aac ggc ttg aaa ctt tgg gat att 96 Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile 20 25 30 cat ttt aga atg acc cgt ttt atc gtc gca aga tgc ggt tta ttg ttt 144 His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe 35 40 45 gca acc ctt aaa gga aaa acc atg aag aaa atg ttc gtg ctg ttc tgt 192 Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys 50 55 60 atg ctg ttc tcc tgc gcc ttc tcc ctt gcg gcg gta aac atc aat gcg 240 Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala 65 70 75 80 gct tcg cag cag gag ctg gag gcg ctg ccg ggc ata ggc cct gcg aag 288 Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys 85 90 95 gcg aag gcc att gcg gaa tac cgt gcg caa aac ggt gcg ttc aag tct 336 Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser 100 105 110 gta gac gat ttg acc aag gta aag ggc atc ggc cct gcg gtg ctg gcg 384 Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala 115 120 125 aag ctg aag gat cag gct tct gtc ggt gcg ccc gca cca aaa ggc cca 432 Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro 130 135 140 gct aaa cca gtg ctg ccc gcg gat aaa aaa 462 Ala Lys Pro Val Leu Pro Ala Asp Lys Lys 145 150 <210> 50 <211> 154 <212> PRT <213> Neisseria meningitidis <400> 50 Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr 1 5 10 15 Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile 20 25 30 His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe 35 40 45 Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys 50 55 60 Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala 65 70 75 80 Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys 85 90 95 Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser 100 105 110 Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala 115 120 125 Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro 130 135 140 Ala Lys Pro Val Leu Pro Ala Asp Lys Lys 145 150 <210> 51 <211> 969 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(969) <400> 51 atg tcc gcc aag ttc caa caa gaa acc ctc aaa tcc cgt ttc gcg caa 48 Met Ser Ala Lys Phe Gln Gln Glu Thr Leu Lys Ser Arg Phe Ala Gln 1 5 10 15 gcc aaa gtc ctg gtt gtc ggc gac gtg atg ctc gac cgc tat tgg ttc 96 Ala Lys Val Leu Val Val Gly Asp Val Met Leu Asp Arg Tyr Trp Phe 20 25 30 ggc gat gtg tcc cgt att tcg ccc gaa gcc ccc gtg ccg gtg gcg aaa 144 Gly Asp Val Ser Arg Ile Ser Pro Glu Ala Pro Val Pro Val Ala Lys 35 40 45 atc gga cga atc gac caa cgc gcg ggc gga gcg gca aat gtc gcg cgc 192 Ile Gly Arg Ile Asp Gln Arg Ala Gly Gly Ala Ala Asn Val Ala Arg 50 55 60 aac atc gct tcg ctg ggc ggc aaa gta ggg ctg ttg tcg gta acc ggt 240 Asn Ile Ala Ser Leu Gly Gly Lys Val Gly Leu Leu Ser Val Thr Gly 65 70 75 80 aac gac gaa gcc gcc gac gcg ctc gac gcg ctg atg gtg cag gac ggc 288 Asn Asp Glu Ala Ala Asp Ala Leu Asp Ala Leu Met Val Gln Asp Gly 85 90 95 gtc gcc tcc tat ctg atg cgc gac aaa caa atc gcc acc acc gtc aaa 336 Val Ala Ser Tyr Leu Met Arg Asp Lys Gln Ile Ala Thr Thr Val Lys 100 105 110 ctg cgc gtc gtc gcc cgc aac cag cag ctt atc cgc ctt gat ttt gaa 384 Leu Arg Val Val Ala Arg Asn Gln Gln Leu Ile Arg Leu Asp Phe Glu 115 120 125 gaa cat ccc aac cgc gaa gtg ttg gaa caa atc aag cgg aaa tac cgc 432 Glu His Pro Asn Arg Glu Val Leu Glu Gln Ile Lys Arg Lys Tyr Arg 130 135 140 gaa atc ttg ccc gaa tac gac gca atc att ttt tca gac tac ggc aaa 480 Glu Ile Leu Pro Glu Tyr Asp Ala Ile Ile Phe Ser Asp Tyr Gly Lys 145 150 155 160 ggc ggc ctg tcg cac atc tcc gat atg atc gat tgg gcg aaa cac gaa 528 Gly Gly Leu Ser His Ile Ser Asp Met Ile Asp Trp Ala Lys His Glu 165 170 175 ggc aaa acc gta tta atc gac ccc aaa ggc gac gat tac gaa aaa tac 576 Gly Lys Thr Val Leu Ile Asp Pro Lys Gly Asp Asp Tyr Glu Lys Tyr 180 185 190 gcc ggc gca acc ctg att acg ccc aac cgc gcc gaa ttg aaa gaa gtg 624 Ala Gly Ala Thr Leu Ile Thr Pro Asn Arg Ala Glu Leu Lys Glu Val 195 200 205 gtc ggc agc tgg aaa aac gaa aat gat ttg acc gaa aaa gcc caa aac 672 Val Gly Ser Trp Lys Asn Glu Asn Asp Leu Thr Glu Lys Ala Gln Asn 210 215 220 ctg cgc cgc cac ctc gac ttg acc gct att tta ctg acc cga agc gaa 720 Leu Arg Arg His Leu Asp Leu Thr Ala Ile Leu Leu Thr Arg Ser Glu 225 230 235 240 gaa ggc atg acc ttg ttc agc gaa ggc gaa ccc att tac cag ccc acc 768 Glu Gly Met Thr Leu Phe Ser Glu Gly Glu Pro Ile Tyr Gln Pro Thr 245 250 255 cgc gcc caa gaa gtt tac gac gta tcc ggt gcg ggc gac acc gtc att 816 Arg Ala Gln Glu Val Tyr Asp Val Ser Gly Ala Gly Asp Thr Val Ile 260 265 270 gcc gga atg ggc ttg ggt ttg gcg gca ggc tgc acc atg ccc gaa gcc 864 Ala Gly Met Gly Leu Gly Leu Ala Ala Gly Cys Thr Met Pro Glu Ala 275 280 285 atg tac ctt gcc aat act gcg gcc ggg gtt gtc gtg gcg aaa ctc ggt 912 Met Tyr Leu Ala Asn Thr Ala Ala Gly Val Val Val Ala Lys Leu Gly 290 295 300 acg gcg gtt tgc tcg ttt gcc gaa ttg acc aag gca ttg tca ggg caa 960 Thr Ala Val Cys Ser Phe Ala Glu Leu Thr Lys Ala Leu Ser Gly Gln 305 310 315 320 tca aca atg 969 Ser Thr Met <210> 52 <211> 323 <212> PRT <213> Neisseria meningitidis <400> 52 Met Ser Ala Lys Phe Gln Gln Glu Thr Leu Lys Ser Arg Phe Ala Gln 1 5 10 15 Ala Lys Val Leu Val Val Gly Asp Val Met Leu Asp Arg Tyr Trp Phe 20 25 30 Gly Asp Val Ser Arg Ile Ser Pro Glu Ala Pro Val Pro Val Ala Lys 35 40 45 Ile Gly Arg Ile Asp Gln Arg Ala Gly Gly Ala Ala Asn Val Ala Arg 50 55 60 Asn Ile Ala Ser Leu Gly Gly Lys Val Gly Leu Leu Ser Val Thr Gly 65 70 75 80 Asn Asp Glu Ala Ala Asp Ala Leu Asp Ala Leu Met Val Gln Asp Gly 85 90 95 Val Ala Ser Tyr Leu Met Arg Asp Lys Gln Ile Ala Thr Thr Val Lys 100 105 110 Leu Arg Val Val Ala Arg Asn Gln Gln Leu Ile Arg Leu Asp Phe Glu 115 120 125 Glu His Pro Asn Arg Glu Val Leu Glu Gln Ile Lys Arg Lys Tyr Arg 130 135 140 Glu Ile Leu Pro Glu Tyr Asp Ala Ile Ile Phe Ser Asp Tyr Gly Lys 145 150 155 160 Gly Gly Leu Ser His Ile Ser Asp Met Ile Asp Trp Ala Lys His Glu 165 170 175 Gly Lys Thr Val Leu Ile Asp Pro Lys Gly Asp Asp Tyr Glu Lys Tyr 180 185 190 Ala Gly Ala Thr Leu Ile Thr Pro Asn Arg Ala Glu Leu Lys Glu Val 195 200 205 Val Gly Ser Trp Lys Asn Glu Asn Asp Leu Thr Glu Lys Ala Gln Asn 210 215 220 Leu Arg Arg His Leu Asp Leu Thr Ala Ile Leu Leu Thr Arg Ser Glu 225 230 235 240 Glu Gly Met Thr Leu Phe Ser Glu Gly Glu Pro Ile Tyr Gln Pro Thr 245 250 255 Arg Ala Gln Glu Val Tyr Asp Val Ser Gly Ala Gly Asp Thr Val Ile 260 265 270 Ala Gly Met Gly Leu Gly Leu Ala Ala Gly Cys Thr Met Pro Glu Ala 275 280 285 Met Tyr Leu Ala Asn Thr Ala Ala Gly Val Val Val Ala Lys Leu Gly 290 295 300 Thr Ala Val Cys Ser Phe Ala Glu Leu Thr Lys Ala Leu Ser Gly Gln 305 310 315 320 Ser Thr Met <210> 53 <211> 864 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(864) <400> 53 atg aaa gca aaa atc ctg act tcc gtt gca ctg ctt gcc tgt tcc ggc 48 Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly 1 5 10 15 agc ctg ttt gcc caa acg ctg gca acc gtc aac ggt cag aaa atc gac 96 Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp 20 25 30 agt tcc gtc att gat gcg cag gtt gcc gca ttc cgt gcg gaa aac agc 144 Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser 35 40 45 cgt gcc gaa gac acg ccg caa ctg cgc caa tcc ctg ctg gaa aac gaa 192 Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu 50 55 60 gtg gtc aac acc gtg gtc gca cag gaa gtg aaa cgc ctg aaa ctc gac 240 Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp 65 70 75 80 cgg tcg gca gag ttt aaa aat gcg ctt gcc aaa ttg cgt gcc gaa gcg 288 Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala 85 90 95 aaa aag tcg ggc gac gac aag aaa ccg tcc ttc aaa acc gtt tgg cag 336 Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln 100 105 110 gcg gta aaa tat ggc ttg aac ggc gag gca tac gcg ctg cat atc gcc 384 Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala 115 120 125 aaa acc caa ccg gtt tcc gag cag gaa gta aaa gcc gca tat gac aat 432 Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn 130 135 140 atc agc ggt ttt tac aaa ggt acg cag gaa gtc cag ttg ggc gaa atc 480 Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile 145 150 155 160 ctg acc gac aag gaa gaa aat gca aaa aaa gcg gtt gcc gac ttg aag 528 Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys 165 170 175 gcg aaa aaa ggt ttc gat gcc gtc ttg aaa caa tat tcc ctc aac gac 576 Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp 180 185 190 cgt acc aaa cag acc ggt gcg ccg gtc gga tat gtg ccg ctg aaa gat 624 Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp 195 200 205 ttg gaa cag ggt gtt ccg ccg ctt tat cag gca att aag gac ttg aaa 672 Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys 210 215 220 aaa ggc gaa ttt acg gca acg ccg ctg aaa aac ggc gat ttc tac ggc 720 Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly 225 230 235 240 gtt tat tat gtc aac gac agc cgc gag gta aaa gtg cct tct ttt gat 768 Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp 245 250 255 gaa atg aaa gga cag att gcg ggc aac ctt cag gcg gaa cgg att gac 816 Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp 260 265 270 cgt gcc gtc ggt gca ctg ttg ggc aag gca aac atc aaa cct gca aaa 864 Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys 275 280 285 <210> 54 <211> 288 <212> PRT <213> Neisseria meningitidis <400> 54 Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly 1 5 10 15 Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp 20 25 30 Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser 35 40 45 Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu 50 55 60 Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp 65 70 75 80 Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala 85 90 95 Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln 100 105 110 Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala 115 120 125 Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn 130 135 140 Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile 145 150 155 160 Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys 165 170 175 Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp 180 185 190 Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp 195 200 205 Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys 210 215 220 Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly 225 230 235 240 Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp 245 250 255 Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp 260 265 270 Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys 275 280 285 <210> 55 <211> 1257 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1257) <400> 55 atg aaa cag acc gtc ctc aaa aat aac ctg caa aac ctg ctt gaa agc 48 Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser 1 5 10 15 gca gaa aat atc ctg ctg ctt caa ggc cct gtc ggc gat ttt ttt ctg 96 Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu 20 25 30 cgc ctt gcc gac tgg ctg act gca aac ggc aaa acc gta cat aaa ttc 144 Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe 35 40 45 aac ttt aat gca ggc gac gac tat ttt tat ccg ccc act caa gcg cat 192 Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His 50 55 60 acc gtt gtt ttt aac gac aac tac gat gcc ttt cct gag ttt ttg caa 240 Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln 65 70 75 80 gaa tac atc act caa cat cac atc cag gcc gtt gtc tgc ttt ggc gac 288 Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp 85 90 95 aca cgc cct tat cac gtc att gca aaa cgc att gca aac gaa aac caa 336 Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln 100 105 110 gcc agt ttc tgg gcg ttt gaa gaa ggc tat ttc cgc ccc tac tac atc 384 Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile 115 120 125 acc tta gaa aaa gac ggc gtc aac gca ttt tcc ccg ttg ccg cgc cgt 432 Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg 130 135 140 gcc gac ttt ttt ctt gaa caa ttc cct aag ctt gcc cag caa gaa tat 480 Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr 145 150 155 160 aaa gcg cca acg ccg gta cac ggc ggt ttt acg ccc atg gca aaa aac 528 Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn 165 170 175 gct atc cgt tac tat atc gag ttg ttc cgc aat cta cgc aaa tac ccc 576 Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro 180 185 190 gac tac atc cac cac cgc gca ccc aat gcc ggc cat tac ctc aaa ccg 624 Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro 195 200 205 tgg tcg ctc tcc atc ctc aag cgt ttg aac tac tat att gaa gac atc 672 Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile 210 215 220 caa atc gcc aaa cgt gtg gaa gca ggc aaa tac ggc aag ttt ttt att 720 Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile 225 230 235 240 gtt ccc ttg cag gta ttc aac gac agc caa gtc cgt atc cat tgc gac 768 Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp 245 250 255 ttt ccc agc gtc cgc agc ttc ctg ctc cat gtt ttg agt tca ttt gcc 816 Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala 260 265 270 gaa cac gcg cct gcc gat acc aac atc atc atc aag cat cat cct atg 864 Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met 275 280 285 gac cgc ggc ttt atc gac tac tgg cgc gac att aaa cgc ttt atc aaa 912 Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys 290 295 300 gaa cac ccc gaa ctc aaa ggc cgt gtg att tat gtc cat gat gtc ccc 960 Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro 305 310 315 320 ctg ccc gtt ttc ctg cgc cac ggt ctc ggc atg gtt acc atc aac agc 1008 Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser 325 330 335 acc agc ggc ctg tcc gga ctg att cac aat atg cca gtt aag gtt ctc 1056 Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu 340 345 350 ggc cgt gcc tat tat gat att ccc ggc att act gac caa aat acc ttg 1104 Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu 355 360 365 gca gaa ttt tgg aat cat ccg aca ccg cct gac aaa gag ctg ttc cat 1152 Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His 370 375 380 gcc tac cga atg tac cac ctc aac gtg acc caa att aac ggc aac ttc 1200 Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe 385 390 395 400 tac agt cag gtc ttt ttt cct aac aaa aac aca tcc gac tct tcc aca 1248 Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr 405 410 415 cca aca acc 1257 Pro Thr Thr <210> 56 <211> 419 <212> PRT <213> Neisseria meningitidis <400> 56 Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser 1 5 10 15 Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu 20 25 30 Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe 35 40 45 Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His 50 55 60 Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln 65 70 75 80 Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp 85 90 95 Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln 100 105 110 Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile 115 120 125 Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg 130 135 140 Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr 145 150 155 160 Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn 165 170 175 Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro 180 185 190 Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro 195 200 205 Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile 210 215 220 Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile 225 230 235 240 Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp 245 250 255 Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala 260 265 270 Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met 275 280 285 Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys 290 295 300 Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro 305 310 315 320 Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser 325 330 335 Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu 340 345 350 Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu 355 360 365 Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His 370 375 380 Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe 385 390 395 400 Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr 405 410 415 Pro Thr Thr <210> 57 <211> 1407 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1407) <400> 57 atg acc tcc aca ttc ccc cgc cgc ctc gcc cgc aaa atc cgc caa acc 48 Met Thr Ser Thr Phe Pro Arg Arg Leu Ala Arg Lys Ile Arg Gln Thr 1 5 10 15 cgc cgc ctg tcg cgc aaa agc atc gcc ttt ctg ttc ctt ttg gca ggt 96 Arg Arg Leu Ser Arg Lys Ser Ile Ala Phe Leu Phe Leu Leu Ala Gly 20 25 30 tcg gca ctc gtc gcc ctg acc gcg ctg ttt ttt gcc cat ctt gcc gat 144 Ser Ala Leu Val Ala Leu Thr Ala Leu Phe Phe Ala His Leu Ala Asp 35 40 45 ttt gcg ctg gaa ctg aac gcc aaa ctg gtt caa caa tac ccg tgg ttc 192 Phe Ala Leu Glu Leu Asn Ala Lys Leu Val Gln Gln Tyr Pro Trp Phe 50 55 60 gcg tgg gtc gcg ctt cct ttg ggt tta ccg ctt att gcg tgg ctc aca 240 Ala Trp Val Ala Leu Pro Leu Gly Leu Pro Leu Ile Ala Trp Leu Thr 65 70 75 80 cgc aaa ttc gcc ccc ttc acc gcc ggc agc ggc atc ccg cag gtc atc 288 Arg Lys Phe Ala Pro Phe Thr Ala Gly Ser Gly Ile Pro Gln Val Ile 85 90 95 gcc tca ctg tcg ctg ccc tac ggc gca cag aaa acg cgg ctg atc cgc 336 Ala Ser Leu Ser Leu Pro Tyr Gly Ala Gln Lys Thr Arg Leu Ile Arg 100 105 110 ctc ggg cag acg ctg ctg aag att ccg cta acc ttt ttg ggt atg ctg 384 Leu Gly Gln Thr Leu Leu Lys Ile Pro Leu Thr Phe Leu Gly Met Leu 115 120 125 ttc ggc gcg tcc atc gga cgc gaa ggt ccg tcc gtg cag gtc ggc gcg 432 Phe Gly Ala Ser Ile Gly Arg Glu Gly Pro Ser Val Gln Val Gly Ala 130 135 140 gca gtg atg ggc gcg tgg ggc gcg tgg tgc aag aaa cac ggc ttg gca 480 Ala Val Met Gly Ala Trp Gly Ala Trp Cys Lys Lys His Gly Leu Ala 145 150 155 160 ttc aaa ggg atg cag gaa aac gat ttg atg gcg gcg ggc gcg gcg ggc 528 Phe Lys Gly Met Gln Glu Asn Asp Leu Met Ala Ala Gly Ala Ala Gly 165 170 175 ggt ttg gca gcc gcg ttc aac gcg ccg ctg gcg ggc gtg att ttc gcc 576 Gly Leu Ala Ala Ala Phe Asn Ala Pro Leu Ala Gly Val Ile Phe Ala 180 185 190 att gag gaa ctc ggg cgc ggc atc atg ttg cgc tgg gag agg caa att 624 Ile Glu Glu Leu Gly Arg Gly Ile Met Leu Arg Trp Glu Arg Gln Ile 195 200 205 ctt ttg ggc gtg ctc gcc tcc ggt ttc ata cag gtc gcc att cag ggc 672 Leu Leu Gly Val Leu Ala Ser Gly Phe Ile Gln Val Ala Ile Gln Gly 210 215 220 aac aac ccg tat ttt tcc ggc ttc aac ggc ggc gta ttg gaa cat atc 720 Asn Asn Pro Tyr Phe Ser Gly Phe Asn Gly Gly Val Leu Glu His Ile 225 230 235 240 ttt ctg tgg gtc gca ctg tcc ggc ctg gtt tgc ggc gcg gcg ggc ggg 768 Phe Leu Trp Val Ala Leu Ser Gly Leu Val Cys Gly Ala Ala Gly Gly 245 250 255 ctg ttc gga cgt ttg ctc tat cgc ggt gcg gcg gcg ttt gca ccg cgc 816 Leu Phe Gly Arg Leu Leu Tyr Arg Gly Ala Ala Ala Phe Ala Pro Arg 260 265 270 aag ata cgc ggc ttc atc cgc aac cgt ccg ctg ctg ctg gcg gca ctg 864 Lys Ile Arg Gly Phe Ile Arg Asn Arg Pro Leu Leu Leu Ala Ala Leu 275 280 285 atg ggg ctg ctg ctc gcc ctg ctc ggc acg ttc tac caa ggc aaa acc 912 Met Gly Leu Leu Leu Ala Leu Leu Gly Thr Phe Tyr Gln Gly Lys Thr 290 295 300 tac ggc acc ggc tac cac gaa gcc gcc caa gcc ctg cac ggc atc tac 960 Tyr Gly Thr Gly Tyr His Glu Ala Ala Gln Ala Leu His Gly Ile Tyr 305 310 315 320 gaa gcc ccc ttc gga ctc gcc gcc gcc aaa tgg ctc gcc acc gta ttc 1008 Glu Ala Pro Phe Gly Leu Ala Ala Ala Lys Trp Leu Ala Thr Val Phe 325 330 335 agc tat tgg gca ggc gtt ccg ggc ggc att ttc act ccc tcg ctg acc 1056 Ser Tyr Trp Ala Gly Val Pro Gly Gly Ile Phe Thr Pro Ser Leu Thr 340 345 350 ata ggc gcg gtt ttg ggc gag cat atc gcc gcc atc gcc gac ata tcg 1104 Ile Gly Ala Val Leu Gly Glu His Ile Ala Ala Ile Ala Asp Ile Ser 355 360 365 cag ggt gca aac atc atc gtc ctc atc tgc atg gcg gca ttt ctg gcg 1152 Gln Gly Ala Asn Ile Ile Val Leu Ile Cys Met Ala Ala Phe Leu Ala 370 375 380 ggc gcg aca caa tcc ccg att act tcc gcc gtc gtc gtc atg gaa atg 1200 Gly Ala Thr Gln Ser Pro Ile Thr Ser Ala Val Val Val Met Glu Met 385 390 395 400 acg ggc gga caa agc ctg ctg ttt tgg atg ctg att gcc tgc att ttc 1248 Thr Gly Gly Gln Ser Leu Leu Phe Trp Met Leu Ile Ala Cys Ile Phe 405 410 415 gcc tcg cag gtt tcg cgc cag ttt tcg ccg cgt ccg ttc tac cac gca 1296 Ala Ser Gln Val Ser Arg Gln Phe Ser Pro Arg Pro Phe Tyr His Ala 420 425 430 tcg gga atg cgc ttc cgc cag cgc gtg ctt caa gaa acc gcc gcc caa 1344 Ser Gly Met Arg Phe Arg Gln Arg Val Leu Gln Glu Thr Ala Ala Gln 435 440 445 acc ggc aat gcg ccc gca aga ccg caa aca gca aac agc aaa acg gga 1392 Thr Gly Asn Ala Pro Ala Arg Pro Gln Thr Ala Asn Ser Lys Thr Gly 450 455 460 atg ccg tct gaa aat 1407 Met Pro Ser Glu Asn 465 <210> 58 <211> 469 <212> PRT <213> Neisseria meningitidis <400> 58 Met Thr Ser Thr Phe Pro Arg Arg Leu Ala Arg Lys Ile Arg Gln Thr 1 5 10 15 Arg Arg Leu Ser Arg Lys Ser Ile Ala Phe Leu Phe Leu Leu Ala Gly 20 25 30 Ser Ala Leu Val Ala Leu Thr Ala Leu Phe Phe Ala His Leu Ala Asp 35 40 45 Phe Ala Leu Glu Leu Asn Ala Lys Leu Val Gln Gln Tyr Pro Trp Phe 50 55 60 Ala Trp Val Ala Leu Pro Leu Gly Leu Pro Leu Ile Ala Trp Leu Thr 65 70 75 80 Arg Lys Phe Ala Pro Phe Thr Ala Gly Ser Gly Ile Pro Gln Val Ile 85 90 95 Ala Ser Leu Ser Leu Pro Tyr Gly Ala Gln Lys Thr Arg Leu Ile Arg 100 105 110 Leu Gly Gln Thr Leu Leu Lys Ile Pro Leu Thr Phe Leu Gly Met Leu 115 120 125 Phe Gly Ala Ser Ile Gly Arg Glu Gly Pro Ser Val Gln Val Gly Ala 130 135 140 Ala Val Met Gly Ala Trp Gly Ala Trp Cys Lys Lys His Gly Leu Ala 145 150 155 160 Phe Lys Gly Met Gln Glu Asn Asp Leu Met Ala Ala Gly Ala Ala Gly 165 170 175 Gly Leu Ala Ala Ala Phe Asn Ala Pro Leu Ala Gly Val Ile Phe Ala 180 185 190 Ile Glu Glu Leu Gly Arg Gly Ile Met Leu Arg Trp Glu Arg Gln Ile 195 200 205 Leu Leu Gly Val Leu Ala Ser Gly Phe Ile Gln Val Ala Ile Gln Gly 210 215 220 Asn Asn Pro Tyr Phe Ser Gly Phe Asn Gly Gly Val Leu Glu His Ile 225 230 235 240 Phe Leu Trp Val Ala Leu Ser Gly Leu Val Cys Gly Ala Ala Gly Gly 245 250 255 Leu Phe Gly Arg Leu Leu Tyr Arg Gly Ala Ala Ala Phe Ala Pro Arg 260 265 270 Lys Ile Arg Gly Phe Ile Arg Asn Arg Pro Leu Leu Leu Ala Ala Leu 275 280 285 Met Gly Leu Leu Leu Ala Leu Leu Gly Thr Phe Tyr Gln Gly Lys Thr 290 295 300 Tyr Gly Thr Gly Tyr His Glu Ala Ala Gln Ala Leu His Gly Ile Tyr 305 310 315 320 Glu Ala Pro Phe Gly Leu Ala Ala Ala Lys Trp Leu Ala Thr Val Phe 325 330 335 Ser Tyr Trp Ala Gly Val Pro Gly Gly Ile Phe Thr Pro Ser Leu Thr 340 345 350 Ile Gly Ala Val Leu Gly Glu His Ile Ala Ala Ile Ala Asp Ile Ser 355 360 365 Gln Gly Ala Asn Ile Ile Val Leu Ile Cys Met Ala Ala Phe Leu Ala 370 375 380 Gly Ala Thr Gln Ser Pro Ile Thr Ser Ala Val Val Val Met Glu Met 385 390 395 400 Thr Gly Gly Gln Ser Leu Leu Phe Trp Met Leu Ile Ala Cys Ile Phe 405 410 415 Ala Ser Gln Val Ser Arg Gln Phe Ser Pro Arg Pro Phe Tyr His Ala 420 425 430 Ser Gly Met Arg Phe Arg Gln Arg Val Leu Gln Glu Thr Ala Ala Gln 435 440 445 Thr Gly Asn Ala Pro Ala Arg Pro Gln Thr Ala Asn Ser Lys Thr Gly 450 455 460 Met Pro Ser Glu Asn 465 <210> 59 <211> 423 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(423) <400> 59 atg aca caa gaa acc gct ttg ggc gca gca ctg aaa tcc gcc gtc caa 48 Met Thr Gln Glu Thr Ala Leu Gly Ala Ala Leu Lys Ser Ala Val Gln 1 5 10 15 act atg agc aaa aag aaa cag aca gaa atg att gcc gac cac atc tac 96 Thr Met Ser Lys Lys Lys Gln Thr Glu Met Ile Ala Asp His Ile Tyr 20 25 30 ggc aaa tat gat gta ttc aaa cga ttt aaa ccg ttg gca ctc ggt atc 144 Gly Lys Tyr Asp Val Phe Lys Arg Phe Lys Pro Leu Ala Leu Gly Ile 35 40 45 gat cag gat ttg att gcc gct ttg ccc caa tac gat gcc gca ctg att 192 Asp Gln Asp Leu Ile Ala Ala Leu Pro Gln Tyr Asp Ala Ala Leu Ile 50 55 60 gca cgc gtc ctc gcc aac cac tgc cgc cgt ccg cgc tat ctg aaa gcc 240 Ala Arg Val Leu Ala Asn His Cys Arg Arg Pro Arg Tyr Leu Lys Ala 65 70 75 80 ttg gcg cgc ggt ggc aaa cgt ttc gat ttg aac aac cgt ttc aaa ggc 288 Leu Ala Arg Gly Gly Lys Arg Phe Asp Leu Asn Asn Arg Phe Lys Gly 85 90 95 gaa gtt acc ccc gaa gaa cag gca atc gcg caa aac cat cct ttc gtg 336 Glu Val Thr Pro Glu Glu Gln Ala Ile Ala Gln Asn His Pro Phe Val 100 105 110 cag cag gct ttg caa cag cag tcc gcc caa gct gtc gcc gaa acg ccg 384 Gln Gln Ala Leu Gln Gln Gln Ser Ala Gln Ala Val Ala Glu Thr Pro 115 120 125 tct gtt gaa gcc gaa gca gcc gaa tct tcc aca aca gaa 423 Ser Val Glu Ala Glu Ala Ala Glu Ser Ser Thr Thr Glu 130 135 140 <210> 60 <211> 141 <212> PRT <213> Neisseria meningitidis <400> 60 Met Thr Gln Glu Thr Ala Leu Gly Ala Ala Leu Lys Ser Ala Val Gln 1 5 10 15 Thr Met Ser Lys Lys Lys Gln Thr Glu Met Ile Ala Asp His Ile Tyr 20 25 30 Gly Lys Tyr Asp Val Phe Lys Arg Phe Lys Pro Leu Ala Leu Gly Ile 35 40 45 Asp Gln Asp Leu Ile Ala Ala Leu Pro Gln Tyr Asp Ala Ala Leu Ile 50 55 60 Ala Arg Val Leu Ala Asn His Cys Arg Arg Pro Arg Tyr Leu Lys Ala 65 70 75 80 Leu Ala Arg Gly Gly Lys Arg Phe Asp Leu Asn Asn Arg Phe Lys Gly 85 90 95 Glu Val Thr Pro Glu Glu Gln Ala Ile Ala Gln Asn His Pro Phe Val 100 105 110 Gln Gln Ala Leu Gln Gln Gln Ser Ala Gln Ala Val Ala Glu Thr Pro 115 120 125 Ser Val Glu Ala Glu Ala Ala Glu Ser Ser Thr Thr Glu 130 135 140 <210> 61 <211> 1377 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1377) <400> 61 atg ttc gct ttc aaa tcc tta ctc gat atg ccg cgc ggt gag gca ctt 48 Met Phe Ala Phe Lys Ser Leu Leu Asp Met Pro Arg Gly Glu Ala Leu 1 5 10 15 gcc gtc gtc gtc gct ctg att gcc gcg atg ggc tat acc atc att tca 96 Ala Val Val Val Ala Leu Ile Ala Ala Met Gly Tyr Thr Ile Ile Ser 20 25 30 ttg gag tgg ctg ccg cat atg tcc att att gcc gcc atc gtc gtg ctg 144 Leu Glu Trp Leu Pro His Met Ser Ile Ile Ala Ala Ile Val Val Leu 35 40 45 att ttg tac ggc ttg gcg cgc ggt ttg aaa tac aac gat atg cag cag 192 Ile Leu Tyr Gly Leu Ala Arg Gly Leu Lys Tyr Asn Asp Met Gln Gln 50 55 60 ggc atg ata ggc gcg ttg aat cag ggt atg ggc gcg att tac ctg ttt 240 Gly Met Ile Gly Ala Leu Asn Gln Gly Met Gly Ala Ile Tyr Leu Phe 65 70 75 80 ttc ttc atc ggg ctg atg gtc agc gcg ctg atg atg agc ggc gcg att 288 Phe Phe Ile Gly Leu Met Val Ser Ala Leu Met Met Ser Gly Ala Ile 85 90 95 ccg acg ctg atg tat tac ggt ttc gga ctg att tcc ccg act tat ttt 336 Pro Thr Leu Met Tyr Tyr Gly Phe Gly Leu Ile Ser Pro Thr Tyr Phe 100 105 110 tat ttt tcc gcc ttc gcg ctg tgt tcc gtc atc ggc gtg tcc atc ggc 384 Tyr Phe Ser Ala Phe Ala Leu Cys Ser Val Ile Gly Val Ser Ile Gly 115 120 125 agc agc ctg acc acc tgc gcc act gtc ggc gtt gcc ttt atg ggt atg 432 Ser Ser Leu Thr Thr Cys Ala Thr Val Gly Val Ala Phe Met Gly Met 130 135 140 gcg gcg gcg ttt cag gcc gat atg gcg atg acg gcg ggc gcg att gtt 480 Ala Ala Ala Phe Gln Ala Asp Met Ala Met Thr Ala Gly Ala Ile Val 145 150 155 160 tcg ggc gca ttt ttt ggc gac aaa atg tcc ccg ctt tcc gat acg acg 528 Ser Gly Ala Phe Phe Gly Asp Lys Met Ser Pro Leu Ser Asp Thr Thr 165 170 175 ggc att tcc gcg tcc att gtc ggt atc gac ctg ttt gaa cac atc aaa 576 Gly Ile Ser Ala Ser Ile Val Gly Ile Asp Leu Phe Glu His Ile Lys 180 185 190 aat atg atg tac acc acc att ccc gcg tgg ctc atc agt gcg gca ctg 624 Asn Met Met Tyr Thr Thr Ile Pro Ala Trp Leu Ile Ser Ala Ala Leu 195 200 205 atg ctg tgg ctt ctt ccc agc gtc gcc gcg cag gat ttg aac agc gtc 672 Met Leu Trp Leu Leu Pro Ser Val Ala Ala Gln Asp Leu Asn Ser Val 210 215 220 gaa tcc ttc cgc agc cag ctt gaa gcc acg gga ttg gtg cac tgc tat 720 Glu Ser Phe Arg Ser Gln Leu Glu Ala Thr Gly Leu Val His Cys Tyr 225 230 235 240 tcg ctg att ccg ttt gcg ctg ttg gtc gtt ttg gca ttg atg cgc gtc 768 Ser Leu Ile Pro Phe Ala Leu Leu Val Val Leu Ala Leu Met Arg Val 245 250 255 aat gcc gtg gtc gct atg ctc ttt acc gtc att gcc gcc gtt gcc gta 816 Asn Ala Val Val Ala Met Leu Phe Thr Val Ile Ala Ala Val Ala Val 260 265 270 acg tat ctg cac agc acg ccc gat ctg cgt cag ctc ggc gcg tgg ttt 864 Thr Tyr Leu His Ser Thr Pro Asp Leu Arg Gln Leu Gly Ala Trp Phe 275 280 285 tac ggc ggc tac aaa ctc gaa ggc gaa gcg ttt aaa gac att gcc aaa 912 Tyr Gly Gly Tyr Lys Leu Glu Gly Glu Ala Phe Lys Asp Ile Ala Lys 290 295 300 ctc att tct cgc ggc ggt ttg gaa agt atg ttt ttc acg cag acc atc 960 Leu Ile Ser Arg Gly Gly Leu Glu Ser Met Phe Phe Thr Gln Thr Ile 305 310 315 320 gtg att ctt ggg atg agc ctt ggc ggg ctg ctg ttt gca ctg ggc gcg 1008 Val Ile Leu Gly Met Ser Leu Gly Gly Leu Leu Phe Ala Leu Gly Ala 325 330 335 att cct tcc ctg ctg gat gcc gtc cgc agc ttt ttg acg aat gcc ggg 1056 Ile Pro Ser Leu Leu Asp Ala Val Arg Ser Phe Leu Thr Asn Ala Gly 340 345 350 cgt gcc aca ttc agc gtt gcc atg act tcg gtc ggg gtt aat ttc ctg 1104 Arg Ala Thr Phe Ser Val Ala Met Thr Ser Val Gly Val Asn Phe Leu 355 360 365 atc ggc gag caa tat ttg agt att ttg ttg tcg ggt gaa acg ttc aaa 1152 Ile Gly Glu Gln Tyr Leu Ser Ile Leu Leu Ser Gly Glu Thr Phe Lys 370 375 380 cct gtt tac gat aag ctc ggt ctg cat tcg cgc aat ctg tcg cgg acg 1200 Pro Val Tyr Asp Lys Leu Gly Leu His Ser Arg Asn Leu Ser Arg Thr 385 390 395 400 ctg gaa gat gcg ggg acg gtc atc aac ccg ctc gta ccg tgg agc gta 1248 Leu Glu Asp Ala Gly Thr Val Ile Asn Pro Leu Val Pro Trp Ser Val 405 410 415 tgc ggc gtg ttc atc agc cac gcg ctg ggc gtg ccg gtt tgg gaa tat 1296 Cys Gly Val Phe Ile Ser His Ala Leu Gly Val Pro Val Trp Glu Tyr 420 425 430 ctg ccg tat gcc ttt ttc tgc tat ttg agt ttg gct ttg acc ctg tta 1344 Leu Pro Tyr Ala Phe Phe Cys Tyr Leu Ser Leu Ala Leu Thr Leu Leu 435 440 445 ttc ggt tgg acg ggg ctg act ttg agc aaa aaa 1377 Phe Gly Trp Thr Gly Leu Thr Leu Ser Lys Lys 450 455 <210> 62 <211> 459 <212> PRT <213> Neisseria meningitidis <400> 62 Met Phe Ala Phe Lys Ser Leu Leu Asp Met Pro Arg Gly Glu Ala Leu 1 5 10 15 Ala Val Val Val Ala Leu Ile Ala Ala Met Gly Tyr Thr Ile Ile Ser 20 25 30 Leu Glu Trp Leu Pro His Met Ser Ile Ile Ala Ala Ile Val Val Leu 35 40 45 Ile Leu Tyr Gly Leu Ala Arg Gly Leu Lys Tyr Asn Asp Met Gln Gln 50 55 60 Gly Met Ile Gly Ala Leu Asn Gln Gly Met Gly Ala Ile Tyr Leu Phe 65 70 75 80 Phe Phe Ile Gly Leu Met Val Ser Ala Leu Met Met Ser Gly Ala Ile 85 90 95 Pro Thr Leu Met Tyr Tyr Gly Phe Gly Leu Ile Ser Pro Thr Tyr Phe 100 105 110 Tyr Phe Ser Ala Phe Ala Leu Cys Ser Val Ile Gly Val Ser Ile Gly 115 120 125 Ser Ser Leu Thr Thr Cys Ala Thr Val Gly Val Ala Phe Met Gly Met 130 135 140 Ala Ala Ala Phe Gln Ala Asp Met Ala Met Thr Ala Gly Ala Ile Val 145 150 155 160 Ser Gly Ala Phe Phe Gly Asp Lys Met Ser Pro Leu Ser Asp Thr Thr 165 170 175 Gly Ile Ser Ala Ser Ile Val Gly Ile Asp Leu Phe Glu His Ile Lys 180 185 190 Asn Met Met Tyr Thr Thr Ile Pro Ala Trp Leu Ile Ser Ala Ala Leu 195 200 205 Met Leu Trp Leu Leu Pro Ser Val Ala Ala Gln Asp Leu Asn Ser Val 210 215 220 Glu Ser Phe Arg Ser Gln Leu Glu Ala Thr Gly Leu Val His Cys Tyr 225 230 235 240 Ser Leu Ile Pro Phe Ala Leu Leu Val Val Leu Ala Leu Met Arg Val 245 250 255 Asn Ala Val Val Ala Met Leu Phe Thr Val Ile Ala Ala Val Ala Val 260 265 270 Thr Tyr Leu His Ser Thr Pro Asp Leu Arg Gln Leu Gly Ala Trp Phe 275 280 285 Tyr Gly Gly Tyr Lys Leu Glu Gly Glu Ala Phe Lys Asp Ile Ala Lys 290 295 300 Leu Ile Ser Arg Gly Gly Leu Glu Ser Met Phe Phe Thr Gln Thr Ile 305 310 315 320 Val Ile Leu Gly Met Ser Leu Gly Gly Leu Leu Phe Ala Leu Gly Ala 325 330 335 Ile Pro Ser Leu Leu Asp Ala Val Arg Ser Phe Leu Thr Asn Ala Gly 340 345 350 Arg Ala Thr Phe Ser Val Ala Met Thr Ser Val Gly Val Asn Phe Leu 355 360 365 Ile Gly Glu Gln Tyr Leu Ser Ile Leu Leu Ser Gly Glu Thr Phe Lys 370 375 380 Pro Val Tyr Asp Lys Leu Gly Leu His Ser Arg Asn Leu Ser Arg Thr 385 390 395 400 Leu Glu Asp Ala Gly Thr Val Ile Asn Pro Leu Val Pro Trp Ser Val 405 410 415 Cys Gly Val Phe Ile Ser His Ala Leu Gly Val Pro Val Trp Glu Tyr 420 425 430 Leu Pro Tyr Ala Phe Phe Cys Tyr Leu Ser Leu Ala Leu Thr Leu Leu 435 440 445 Phe Gly Trp Thr Gly Leu Thr Leu Ser Lys Lys 450 455 <210> 63 <211> 1098 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1098) <400> 63 atg gca ggc aac act ttc gga caa ctc ttc acc gtt acc acc ttc ggc 48 Met Ala Gly Asn Thr Phe Gly Gln Leu Phe Thr Val Thr Thr Phe Gly 1 5 10 15 gaa agc cac ggc gcg ggt ttg ggc tgt atc atc gac ggc tgc ccg ccc 96 Glu Ser His Gly Ala Gly Leu Gly Cys Ile Ile Asp Gly Cys Pro Pro 20 25 30 ggc ttg gaa tta agc gaa gcg gat atc caa ttt gac ctc gac cga cgc 144 Gly Leu Glu Leu Ser Glu Ala Asp Ile Gln Phe Asp Leu Asp Arg Arg 35 40 45 aaa ccc ggc acc agc cgc cac gtt acc caa cgc cgc gaa gcc gac caa 192 Lys Pro Gly Thr Ser Arg His Val Thr Gln Arg Arg Glu Ala Asp Gln 50 55 60 gtc gaa atc ctc tcc ggc gta ttc gaa ggc aaa acc acc ggc acg ccc 240 Val Glu Ile Leu Ser Gly Val Phe Glu Gly Lys Thr Thr Gly Thr Pro 65 70 75 80 atc gcc ctc tta atc cgc aat acc gac cag cgc agc aaa gac tac ggc 288 Ile Ala Leu Leu Ile Arg Asn Thr Asp Gln Arg Ser Lys Asp Tyr Gly 85 90 95 aac atc gcc acc agc ttc cgc ccc ggc cac gcc gac tat acc tat tgg 336 Asn Ile Ala Thr Ser Phe Arg Pro Gly His Ala Asp Tyr Thr Tyr Trp 100 105 110 cac aaa tac ggc acg cgc gac tac cgg ggc ggc ggc agg agt tcc gcc 384 His Lys Tyr Gly Thr Arg Asp Tyr Arg Gly Gly Gly Arg Ser Ser Ala 115 120 125 cgc gaa acc gcc gcc cgc gtt gcc gcc gga gcc gtt gcc aaa aaa tgg 432 Arg Glu Thr Ala Ala Arg Val Ala Ala Gly Ala Val Ala Lys Lys Trp 130 135 140 ttg aaa gaa aaa ttc ggc acg gaa atc acc gcc tac gtt acc caa gtc 480 Leu Lys Glu Lys Phe Gly Thr Glu Ile Thr Ala Tyr Val Thr Gln Val 145 150 155 160 ggc gaa aaa gaa atc cgg ttt gaa ggc tgc gaa cac att tcc caa aat 528 Gly Glu Lys Glu Ile Arg Phe Glu Gly Cys Glu His Ile Ser Gln Asn 165 170 175 cct ttt ttt gcc gcc aac cat agc caa att gcc gag ctg gaa aac tat 576 Pro Phe Phe Ala Ala Asn His Ser Gln Ile Ala Glu Leu Glu Asn Tyr 180 185 190 atg gac agc gtg cgc aaa tcc ttg gat tcc gtc ggc gcg aag ctg cat 624 Met Asp Ser Val Arg Lys Ser Leu Asp Ser Val Gly Ala Lys Leu His 195 200 205 att gaa gcc gcc aac gtc ccc gtc ggc ttg ggc gaa ccc gta ttc gac 672 Ile Glu Ala Ala Asn Val Pro Val Gly Leu Gly Glu Pro Val Phe Asp 210 215 220 cgc ctc gat gcc gaa atc gcc tac gcc atg atg ggc atc aac gcc gtc 720 Arg Leu Asp Ala Glu Ile Ala Tyr Ala Met Met Gly Ile Asn Ala Val 225 230 235 240 aaa ggc gtg gaa atc ggc gca ggt ttt gac agc gta acg caa cgc ggc 768 Lys Gly Val Glu Ile Gly Ala Gly Phe Asp Ser Val Thr Gln Arg Gly 245 250 255 agc gaa cac ggc gac gaa ctc acc ccg caa ggc ttc ctg tcc aac cac 816 Ser Glu His Gly Asp Glu Leu Thr Pro Gln Gly Phe Leu Ser Asn His 260 265 270 tca ggc ggc atc ctc ggc ggc atc agc acc gga caa gac atc cac gtc 864 Ser Gly Gly Ile Leu Gly Gly Ile Ser Thr Gly Gln Asp Ile His Val 275 280 285 aat atc gcc atc aaa ccc acc agc tcc atc gcc acc ccg cgc cgc agt 912 Asn Ile Ala Ile Lys Pro Thr Ser Ser Ile Ala Thr Pro Arg Arg Ser 290 295 300 atc gac atc aac ggc aac ccc atc gaa ctc gcc acg cac ggc agg cac 960 Ile Asp Ile Asn Gly Asn Pro Ile Glu Leu Ala Thr His Gly Arg His 305 310 315 320 gac ccc tgc gtc ggc ttg cgc gcc gcg ccg att gca gaa gct atg ctg 1008 Asp Pro Cys Val Gly Leu Arg Ala Ala Pro Ile Ala Glu Ala Met Leu 325 330 335 gca ttg gtt tta atc gac cac gcc ctg cgc cat cgc gcg caa aat gcg 1056 Ala Leu Val Leu Ile Asp His Ala Leu Arg His Arg Ala Gln Asn Ala 340 345 350 gat gtt cag gtt aat acg ccc gac att acc ctt tca aac aaa 1098 Asp Val Gln Val Asn Thr Pro Asp Ile Thr Leu Ser Asn Lys 355 360 365 <210> 64 <211> 366 <212> PRT <213> Neisseria meningitidis <400> 64 Met Ala Gly Asn Thr Phe Gly Gln Leu Phe Thr Val Thr Thr Phe Gly 1 5 10 15 Glu Ser His Gly Ala Gly Leu Gly Cys Ile Ile Asp Gly Cys Pro Pro 20 25 30 Gly Leu Glu Leu Ser Glu Ala Asp Ile Gln Phe Asp Leu Asp Arg Arg 35 40 45 Lys Pro Gly Thr Ser Arg His Val Thr Gln Arg Arg Glu Ala Asp Gln 50 55 60 Val Glu Ile Leu Ser Gly Val Phe Glu Gly Lys Thr Thr Gly Thr Pro 65 70 75 80 Ile Ala Leu Leu Ile Arg Asn Thr Asp Gln Arg Ser Lys Asp Tyr Gly 85 90 95 Asn Ile Ala Thr Ser Phe Arg Pro Gly His Ala Asp Tyr Thr Tyr Trp 100 105 110 His Lys Tyr Gly Thr Arg Asp Tyr Arg Gly Gly Gly Arg Ser Ser Ala 115 120 125 Arg Glu Thr Ala Ala Arg Val Ala Ala Gly Ala Val Ala Lys Lys Trp 130 135 140 Leu Lys Glu Lys Phe Gly Thr Glu Ile Thr Ala Tyr Val Thr Gln Val 145 150 155 160 Gly Glu Lys Glu Ile Arg Phe Glu Gly Cys Glu His Ile Ser Gln Asn 165 170 175 Pro Phe Phe Ala Ala Asn His Ser Gln Ile Ala Glu Leu Glu Asn Tyr 180 185 190 Met Asp Ser Val Arg Lys Ser Leu Asp Ser Val Gly Ala Lys Leu His 195 200 205 Ile Glu Ala Ala Asn Val Pro Val Gly Leu Gly Glu Pro Val Phe Asp 210 215 220 Arg Leu Asp Ala Glu Ile Ala Tyr Ala Met Met Gly Ile Asn Ala Val 225 230 235 240 Lys Gly Val Glu Ile Gly Ala Gly Phe Asp Ser Val Thr Gln Arg Gly 245 250 255 Ser Glu His Gly Asp Glu Leu Thr Pro Gln Gly Phe Leu Ser Asn His 260 265 270 Ser Gly Gly Ile Leu Gly Gly Ile Ser Thr Gly Gln Asp Ile His Val 275 280 285 Asn Ile Ala Ile Lys Pro Thr Ser Ser Ile Ala Thr Pro Arg Arg Ser 290 295 300 Ile Asp Ile Asn Gly Asn Pro Ile Glu Leu Ala Thr His Gly Arg His 305 310 315 320 Asp Pro Cys Val Gly Leu Arg Ala Ala Pro Ile Ala Glu Ala Met Leu 325 330 335 Ala Leu Val Leu Ile Asp His Ala Leu Arg His Arg Ala Gln Asn Ala 340 345 350 Asp Val Gln Val Asn Thr Pro Asp Ile Thr Leu Ser Asn Lys 355 360 365 <210> 65 <211> 461 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(459) <400> 65 atg caa agc ggt ttt aac gct att ttc agg aat gac acc atg cag gtt 48 Met Gln Ser Gly Phe Asn Ala Ile Phe Arg Asn Asp Thr Met Gln Val 1 5 10 15 aca tca aaa tgg ata gac gga atg tgc ttt gtc gga aca acg gaa ggc 96 Thr Ser Lys Trp Ile Asp Gly Met Cys Phe Val Gly Thr Thr Glu Gly 20 25 30 ggg cac agc gtc gtt atg gag ggg tcg gcg gca gaa ggt gcg gcc aag 144 Gly His Ser Val Val Met Glu Gly Ser Ala Ala Glu Gly Ala Ala Lys 35 40 45 cgc ggg ccc agc cct ttg gaa atg ctg ctg ttg ggc gtg gcg ggc tgt 192 Arg Gly Pro Ser Pro Leu Glu Met Leu Leu Leu Gly Val Ala Gly Cys 50 55 60 tcg agc atc gat gtg gtg atg att gcc gaa aaa cag cgt cag aaa gtg 240 Ser Ser Ile Asp Val Val Met Ile Ala Glu Lys Gln Arg Gln Lys Val 65 70 75 80 act gac tgc cgt gcg acg gtt acg gcg aaa cgg gcg gac gat gcg ccg 288 Thr Asp Cys Arg Ala Thr Val Thr Ala Lys Arg Ala Asp Asp Ala Pro 85 90 95 cgc gtg ttt acc gaa atc cac atc cat ttc aaa gta ttc ggg cat gat 336 Arg Val Phe Thr Glu Ile His Ile His Phe Lys Val Phe Gly His Asp 100 105 110 ttg aaa gaa tcg gcc att gag cgc gcc gtt cag atg tct gcc gaa aaa 384 Leu Lys Glu Ser Ala Ile Glu Arg Ala Val Gln Met Ser Ala Glu Lys 115 120 125 tac tgt tcg gct tcg att atg ttg ggc aaa gcg gca aag att acc cac 432 Tyr Cys Ser Ala Ser Ile Met Leu Gly Lys Ala Ala Lys Ile Thr His 130 135 140 agt ttt gaa att gcc ggg gca gat aaa ta 461 Ser Phe Glu Ile Ala Gly Ala Asp Lys 145 150 <210> 66 <211> 153 <212> PRT <213> Neisseria meningitidis <400> 66 Met Gln Ser Gly Phe Asn Ala Ile Phe Arg Asn Asp Thr Met Gln Val 1 5 10 15 Thr Ser Lys Trp Ile Asp Gly Met Cys Phe Val Gly Thr Thr Glu Gly 20 25 30 Gly His Ser Val Val Met Glu Gly Ser Ala Ala Glu Gly Ala Ala Lys 35 40 45 Arg Gly Pro Ser Pro Leu Glu Met Leu Leu Leu Gly Val Ala Gly Cys 50 55 60 Ser Ser Ile Asp Val Val Met Ile Ala Glu Lys Gln Arg Gln Lys Val 65 70 75 80 Thr Asp Cys Arg Ala Thr Val Thr Ala Lys Arg Ala Asp Asp Ala Pro 85 90 95 Arg Val Phe Thr Glu Ile His Ile His Phe Lys Val Phe Gly His Asp 100 105 110 Leu Lys Glu Ser Ala Ile Glu Arg Ala Val Gln Met Ser Ala Glu Lys 115 120 125 Tyr Cys Ser Ala Ser Ile Met Leu Gly Lys Ala Ala Lys Ile Thr His 130 135 140 Ser Phe Glu Ile Ala Gly Ala Asp Lys 145 150 <210> 67 <211> 1659 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1659) <400> 67 atg act gac aac agc cct cct cca aac gga cac gcc caa gca cgc gtc 48 Met Thr Asp Asn Ser Pro Pro Pro Asn Gly His Ala Gln Ala Arg Val 1 5 10 15 cgc aaa aac aac acc ttc ctc tct gcc gtc tgg ctg gtt ccg ctg atc 96 Arg Lys Asn Asn Thr Phe Leu Ser Ala Val Trp Leu Val Pro Leu Ile 20 25 30 gcg ctg att gcc ggc ggc tgg ctt tgg gtt aag gaa atc cgc aac agg 144 Ala Leu Ile Ala Gly Gly Trp Leu Trp Val Lys Glu Ile Arg Asn Arg 35 40 45 ggg cct gtg gtt acg ctc ttg atg gac agc gcg gaa ggc att gag gtc 192 Gly Pro Val Val Thr Leu Leu Met Asp Ser Ala Glu Gly Ile Glu Val 50 55 60 aac aat acg gtc atc aaa gta ttg agc atc gat gtc gga cgc gtt acc 240 Asn Asn Thr Val Ile Lys Val Leu Ser Ile Asp Val Gly Arg Val Thr 65 70 75 80 cga atc aaa ctg cgc gac gac caa aaa ggc gtg gaa gta acc gcc caa 288 Arg Ile Lys Leu Arg Asp Asp Gln Lys Gly Val Glu Val Thr Ala Gln 85 90 95 ctc aat gcg gac gta tcc ggc ctc atc cgc agc gat acc cag ttt tgg 336 Leu Asn Ala Asp Val Ser Gly Leu Ile Arg Ser Asp Thr Gln Phe Trp 100 105 110 gtg gtc aag ccg cgt atc gac caa agc ggc gta acc ggt ttg ggt acg 384 Val Val Lys Pro Arg Ile Asp Gln Ser Gly Val Thr Gly Leu Gly Thr 115 120 125 ctg ctt tcg ggt tcg tac atc gcc ttt aca ccc ggc aaa agc gac gag 432 Leu Leu Ser Gly Ser Tyr Ile Ala Phe Thr Pro Gly Lys Ser Asp Glu 130 135 140 gca aaa gac gtg ttc caa gtg cag gac att ccg ccc gtt acc gcc atc 480 Ala Lys Asp Val Phe Gln Val Gln Asp Ile Pro Pro Val Thr Ala Ile 145 150 155 160 ggg caa agc ggg ctg cgc ttg aat ttg att ggt aaa aac gac cgc atc 528 Gly Gln Ser Gly Leu Arg Leu Asn Leu Ile Gly Lys Asn Asp Arg Ile 165 170 175 ctc aac gtc aac agc cct gtt ttg tat gaa aac ttt atg gtc ggg caa 576 Leu Asn Val Asn Ser Pro Val Leu Tyr Glu Asn Phe Met Val Gly Gln 180 185 190 gtc gaa agc gcg cat ttc gac ccg tcc gac caa agc gtg cat tac acc 624 Val Glu Ser Ala His Phe Asp Pro Ser Asp Gln Ser Val His Tyr Thr 195 200 205 atc ttc atc caa agc ccc aac gac aaa ctg att cat tcc gcc agc cgt 672 Ile Phe Ile Gln Ser Pro Asn Asp Lys Leu Ile His Ser Ala Ser Arg 210 215 220 ttc tgg ctg gaa agc ggc atc aat atc gaa acc aca ggc agc ggc atc 720 Phe Trp Leu Glu Ser Gly Ile Asn Ile Glu Thr Thr Gly Ser Gly Ile 225 230 235 240 aaa ctc aat tcc gcc cct ctg cct gcc ctg ctg tcg ggc gcg att tca 768 Lys Leu Asn Ser Ala Pro Leu Pro Ala Leu Leu Ser Gly Ala Ile Ser 245 250 255 ttt gat tcg ccg aaa acc aaa aac agt aaa aac gtc aaa agc gaa gac 816 Phe Asp Ser Pro Lys Thr Lys Asn Ser Lys Asn Val Lys Ser Glu Asp 260 265 270 agc ttc acg ctt tac gac agc cgc agc gaa gtc gcc aac ctg cct gat 864 Ser Phe Thr Leu Tyr Asp Ser Arg Ser Glu Val Ala Asn Leu Pro Asp 275 280 285 gac cgt tcg ctg tac tac acc gcg ttt ttc aaa caa tcc gtg cgc gga 912 Asp Arg Ser Leu Tyr Tyr Thr Ala Phe Phe Lys Gln Ser Val Arg Gly 290 295 300 ctg acc gtc ggt tcg cct gtc gag tac aaa ggg ctg aat gtc ggc gtg 960 Leu Thr Val Gly Ser Pro Val Glu Tyr Lys Gly Leu Asn Val Gly Val 305 310 315 320 gtt tcc gat gtt cct tat ttc gac cgc aac gac agc ctg cac ctg ttt 1008 Val Ser Asp Val Pro Tyr Phe Asp Arg Asn Asp Ser Leu His Leu Phe 325 330 335 gaa aac ggc tgg att ccc gta cgc atc cgt att gag cct tcc cgt ttg 1056 Glu Asn Gly Trp Ile Pro Val Arg Ile Arg Ile Glu Pro Ser Arg Leu 340 345 350 gaa atc aat gcc gac gaa caa agc aaa gaa cat tgg aaa caa caa ttt 1104 Glu Ile Asn Ala Asp Glu Gln Ser Lys Glu His Trp Lys Gln Gln Phe 355 360 365 cag acg gcc tta aac aaa ggc ctg acc gcc acc atc tcc agc aac aac 1152 Gln Thr Ala Leu Asn Lys Gly Leu Thr Ala Thr Ile Ser Ser Asn Asn 370 375 380 ctg ctg acc ggc agc aaa atg att gag ttg aac gat cag cct tcc gcc 1200 Leu Leu Thr Gly Ser Lys Met Ile Glu Leu Asn Asp Gln Pro Ser Ala 385 390 395 400 tcg ccc aag ctg cga ccg cat acc gtt tat gca ggc gat acc gtt atc 1248 Ser Pro Lys Leu Arg Pro His Thr Val Tyr Ala Gly Asp Thr Val Ile 405 410 415 gcg acc cag ggc ggc ggt ttg gac gat ttg cag gtc aaa ttg gcg gat 1296 Ala Thr Gln Gly Gly Gly Leu Asp Asp Leu Gln Val Lys Leu Ala Asp 420 425 430 ttg ctg gac aag ttc gac aaa ctg cct tta gat aag acg gtt gcc gaa 1344 Leu Leu Asp Lys Phe Asp Lys Leu Pro Leu Asp Lys Thr Val Ala Glu 435 440 445 ttg aac ggt tcg ctt gcc gag ctc aaa tcc aca ctc aaa tct gcc aat 1392 Leu Asn Gly Ser Leu Ala Glu Leu Lys Ser Thr Leu Lys Ser Ala Asn 450 455 460 gcc gcc cta agc tcc atc gac aaa ctg gtc ggc aaa ccg cag aca caa 1440 Ala Ala Leu Ser Ser Ile Asp Lys Leu Val Gly Lys Pro Gln Thr Gln 465 470 475 480 aac att ccg aac gaa ctg aac caa acc ctg aaa gag ttg cgc aca acc 1488 Asn Ile Pro Asn Glu Leu Asn Gln Thr Leu Lys Glu Leu Arg Thr Thr 485 490 495 ctg caa ggc gta tcg cct caa tcg cct atc tac ggc gac gta caa aat 1536 Leu Gln Gly Val Ser Pro Gln Ser Pro Ile Tyr Gly Asp Val Gln Asn 500 505 510 acg ctg caa agt ttg gac aaa acc tta aaa gac gtt caa ccc gtc att 1584 Thr Leu Gln Ser Leu Asp Lys Thr Leu Lys Asp Val Gln Pro Val Ile 515 520 525 aac act ttg aaa gaa aaa ccc aac gcg ctg att ttc aac agc agc agc 1632 Asn Thr Leu Lys Glu Lys Pro Asn Ala Leu Ile Phe Asn Ser Ser Ser 530 535 540 aaa gac cct atc ccg aaa gga agc cga 1659 Lys Asp Pro Ile Pro Lys Gly Ser Arg 545 550 <210> 68 <211> 553 <212> PRT <213> Neisseria meningitidis <400> 68 Met Thr Asp Asn Ser Pro Pro Pro Asn Gly His Ala Gln Ala Arg Val 1 5 10 15 Arg Lys Asn Asn Thr Phe Leu Ser Ala Val Trp Leu Val Pro Leu Ile 20 25 30 Ala Leu Ile Ala Gly Gly Trp Leu Trp Val Lys Glu Ile Arg Asn Arg 35 40 45 Gly Pro Val Val Thr Leu Leu Met Asp Ser Ala Glu Gly Ile Glu Val 50 55 60 Asn Asn Thr Val Ile Lys Val Leu Ser Ile Asp Val Gly Arg Val Thr 65 70 75 80 Arg Ile Lys Leu Arg Asp Asp Gln Lys Gly Val Glu Val Thr Ala Gln 85 90 95 Leu Asn Ala Asp Val Ser Gly Leu Ile Arg Ser Asp Thr Gln Phe Trp 100 105 110 Val Val Lys Pro Arg Ile Asp Gln Ser Gly Val Thr Gly Leu Gly Thr 115 120 125 Leu Leu Ser Gly Ser Tyr Ile Ala Phe Thr Pro Gly Lys Ser Asp Glu 130 135 140 Ala Lys Asp Val Phe Gln Val Gln Asp Ile Pro Pro Val Thr Ala Ile 145 150 155 160 Gly Gln Ser Gly Leu Arg Leu Asn Leu Ile Gly Lys Asn Asp Arg Ile 165 170 175 Leu Asn Val Asn Ser Pro Val Leu Tyr Glu Asn Phe Met Val Gly Gln 180 185 190 Val Glu Ser Ala His Phe Asp Pro Ser Asp Gln Ser Val His Tyr Thr 195 200 205 Ile Phe Ile Gln Ser Pro Asn Asp Lys Leu Ile His Ser Ala Ser Arg 210 215 220 Phe Trp Leu Glu Ser Gly Ile Asn Ile Glu Thr Thr Gly Ser Gly Ile 225 230 235 240 Lys Leu Asn Ser Ala Pro Leu Pro Ala Leu Leu Ser Gly Ala Ile Ser 245 250 255 Phe Asp Ser Pro Lys Thr Lys Asn Ser Lys Asn Val Lys Ser Glu Asp 260 265 270 Ser Phe Thr Leu Tyr Asp Ser Arg Ser Glu Val Ala Asn Leu Pro Asp 275 280 285 Asp Arg Ser Leu Tyr Tyr Thr Ala Phe Phe Lys Gln Ser Val Arg Gly 290 295 300 Leu Thr Val Gly Ser Pro Val Glu Tyr Lys Gly Leu Asn Val Gly Val 305 310 315 320 Val Ser Asp Val Pro Tyr Phe Asp Arg Asn Asp Ser Leu His Leu Phe 325 330 335 Glu Asn Gly Trp Ile Pro Val Arg Ile Arg Ile Glu Pro Ser Arg Leu 340 345 350 Glu Ile Asn Ala Asp Glu Gln Ser Lys Glu His Trp Lys Gln Gln Phe 355 360 365 Gln Thr Ala Leu Asn Lys Gly Leu Thr Ala Thr Ile Ser Ser Asn Asn 370 375 380 Leu Leu Thr Gly Ser Lys Met Ile Glu Leu Asn Asp Gln Pro Ser Ala 385 390 395 400 Ser Pro Lys Leu Arg Pro His Thr Val Tyr Ala Gly Asp Thr Val Ile 405 410 415 Ala Thr Gln Gly Gly Gly Leu Asp Asp Leu Gln Val Lys Leu Ala Asp 420 425 430 Leu Leu Asp Lys Phe Asp Lys Leu Pro Leu Asp Lys Thr Val Ala Glu 435 440 445 Leu Asn Gly Ser Leu Ala Glu Leu Lys Ser Thr Leu Lys Ser Ala Asn 450 455 460 Ala Ala Leu Ser Ser Ile Asp Lys Leu Val Gly Lys Pro Gln Thr Gln 465 470 475 480 Asn Ile Pro Asn Glu Leu Asn Gln Thr Leu Lys Glu Leu Arg Thr Thr 485 490 495 Leu Gln Gly Val Ser Pro Gln Ser Pro Ile Tyr Gly Asp Val Gln Asn 500 505 510 Thr Leu Gln Ser Leu Asp Lys Thr Leu Lys Asp Val Gln Pro Val Ile 515 520 525 Asn Thr Leu Lys Glu Lys Pro Asn Ala Leu Ile Phe Asn Ser Ser Ser 530 535 540 Lys Asp Pro Ile Pro Lys Gly Ser Arg 545 550 <210> 69 <211> 330 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(330) <400> 69 ttg ccg ctg ctt tgt tgt ctt tgg ttt tgg cag cct gcg gcg gtg aaa 48 Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys 1 5 10 15 aag ccg ctg aag ctc ccg ctg ctg aag cac ctg ccg ccg aag ctc ccg 96 Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro 20 25 30 cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg aag cac ctg ccg 144 Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro 35 40 45 ccg aag ctc ctg cta ctg aag cac ctg ccg ccg aag ctc ccg ctg ctg 192 Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu 50 55 60 aag ctg ccg cta ccg aag cac ctg ccg ctg aag ctg ccg cta ccg aag 240 Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys 65 70 75 80 cac ctg ccg ctg aag ctc ctg ctg ccg aag ctg caa aat aag cat ttt 288 His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe 85 90 95 ccg ctt gca aaa aag cag gat acg ttc agt atc ctg ctt ttt 330 Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe 100 105 110 <210> 70 <211> 110 <212> PRT <213> Neisseria meningitidis <400> 70 Leu Pro Leu Leu Cys Cys Leu Trp Phe Trp Gln Pro Ala Ala Val Lys 1 5 10 15 Lys Pro Leu Lys Leu Pro Leu Leu Lys His Leu Pro Pro Lys Leu Pro 20 25 30 Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu Lys His Leu Pro 35 40 45 Pro Lys Leu Leu Leu Leu Lys His Leu Pro Pro Lys Leu Pro Leu Leu 50 55 60 Lys Leu Pro Leu Pro Lys His Leu Pro Leu Lys Leu Pro Leu Pro Lys 65 70 75 80 His Leu Pro Leu Lys Leu Leu Leu Pro Lys Leu Gln Asn Lys His Phe 85 90 95 Pro Leu Ala Lys Lys Gln Asp Thr Phe Ser Ile Leu Leu Phe 100 105 110 <210> 71 <211> 2274 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2274) <400> 71 atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc 48 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag 96 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa 144 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act 192 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc 240 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc 288 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa 336 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat 384 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa 432 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg 480 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt 528 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act 576 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct 624 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt 672 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac 720 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt 768 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg 816 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc 864 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt 912 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg 960 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc 1008 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc 1056 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct 1104 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc 1152 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat 1200 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc 1248 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac 1296 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc 1344 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa 1392 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac 1440 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc 1488 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa 1536 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta 1584 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc 1632 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att 1680 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt 1728 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa 1776 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc 1824 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc 1872 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc 1920 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att 1968 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac 2016 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc 2064 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc 2112 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa 2160 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa 2208 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg 2256 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 cgt gcc gaa ttg gcg aaa 2274 Arg Ala Glu Leu Ala Lys 755 <210> 72 <211> 758 <212> PRT <213> Neisseria meningitidis <400> 72 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 Arg Ala Glu Leu Ala Lys 755 <210> 73 <211> 2118 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2118) <400> 73 atg cgc cgt ttt cta ccg atc gca gcc ata tgc gcc gtc gtc ctg ttg 48 Met Arg Arg Phe Leu Pro Ile Ala Ala Ile Cys Ala Val Val Leu Leu 1 5 10 15 tac gga ctg acg gcg gca acc ggc agc acc agt tcg ctg gcg gat tat 96 Tyr Gly Leu Thr Ala Ala Thr Gly Ser Thr Ser Ser Leu Ala Asp Tyr 20 25 30 ttc tgg tgg att gtt gcg ttc agc gca atg ctg ctg ctg gtg ttg tcc 144 Phe Trp Trp Ile Val Ala Phe Ser Ala Met Leu Leu Leu Val Leu Ser 35 40 45 gcc gtt ttg gca cgt tat gtc ata ttg ctg ttg aaa gac agg cgc gac 192 Ala Val Leu Ala Arg Tyr Val Ile Leu Leu Leu Lys Asp Arg Arg Asp 50 55 60 ggc gta ttc ggt tcg cag att gcc aaa cgc ctt tcc ggg atg ttt acg 240 Gly Val Phe Gly Ser Gln Ile Ala Lys Arg Leu Ser Gly Met Phe Thr 65 70 75 80 ctg gtt gcc gta ctg ccc ggc gtg ttt ctg ttc ggc gtt tcc gca cag 288 Leu Val Ala Val Leu Pro Gly Val Phe Leu Phe Gly Val Ser Ala Gln 85 90 95 ttt atc aac ggc acg att aat tcg tgg ttc ggc aac gat acc cac gag 336 Phe Ile Asn Gly Thr Ile Asn Ser Trp Phe Gly Asn Asp Thr His Glu 100 105 110 gcg ctt gaa cgc agc ctc aat ttg agc aag tcc gca ttg aat ctg gcg 384 Ala Leu Glu Arg Ser Leu Asn Leu Ser Lys Ser Ala Leu Asn Leu Ala 115 120 125 gca gac aac gcc ctt ggc aac gcc atc ccc gtg cag ata gac ctc atc 432 Ala Asp Asn Ala Leu Gly Asn Ala Ile Pro Val Gln Ile Asp Leu Ile 130 135 140 ggc gcg gct tcc ctg ccc ggg gat atg ggc agg gtg ctg gaa cat tac 480 Gly Ala Ala Ser Leu Pro Gly Asp Met Gly Arg Val Leu Glu His Tyr 145 150 155 160 gcc ggc agc ggt ttt gcc cag ctt gcc ctg tac aat gcc gca agc ggc 528 Ala Gly Ser Gly Phe Ala Gln Leu Ala Leu Tyr Asn Ala Ala Ser Gly 165 170 175 aaa atc gaa aaa agc atc aac ccg cac aag ctc gat cag ccg ttt cca 576 Lys Ile Glu Lys Ser Ile Asn Pro His Lys Leu Asp Gln Pro Phe Pro 180 185 190 ggt aag gcg cgt tgg gaa aaa atc caa cag gcg ggt tcg gtc agg gat 624 Gly Lys Ala Arg Trp Glu Lys Ile Gln Gln Ala Gly Ser Val Arg Asp 195 200 205 ttg gaa agc ata ggc ggc gta ttg tac gcg cag ggc tgg ctg tcg gca 672 Leu Glu Ser Ile Gly Gly Val Leu Tyr Ala Gln Gly Trp Leu Ser Ala 210 215 220 ggt acg cac aac ggg cgc gat tac gcc ttg ttt ttc cgt cag ccg gtt 720 Gly Thr His Asn Gly Arg Asp Tyr Ala Leu Phe Phe Arg Gln Pro Val 225 230 235 240 ccc aaa ggc gtg gca gag gat gcc gtc tta atc gaa aag gca agg gcg 768 Pro Lys Gly Val Ala Glu Asp Ala Val Leu Ile Glu Lys Ala Arg Ala 245 250 255 aaa tat gct gag ttg agt tac agc aaa aaa ggt ttg cag acc ttt ttc 816 Lys Tyr Ala Glu Leu Ser Tyr Ser Lys Lys Gly Leu Gln Thr Phe Phe 260 265 270 ctg gca acc ctg ctg att gcc tcg ctg ctg tcg att ttt ctt gca ctg 864 Leu Ala Thr Leu Leu Ile Ala Ser Leu Leu Ser Ile Phe Leu Ala Leu 275 280 285 gtc atg gca ctg tat ttc gcc cgc cgt ttc gtc gaa ccc gtc cta tcg 912 Val Met Ala Leu Tyr Phe Ala Arg Arg Phe Val Glu Pro Val Leu Ser 290 295 300 ctt gcc gag ggg gcg aag gcg gtg gcg caa ggc gat ttc agc cag acg 960 Leu Ala Glu Gly Ala Lys Ala Val Ala Gln Gly Asp Phe Ser Gln Thr 305 310 315 320 cgc ccc gtg ttg cgc aac gac gag ttc gga cgc ttg acc aag ttg ttc 1008 Arg Pro Val Leu Arg Asn Asp Glu Phe Gly Arg Leu Thr Lys Leu Phe 325 330 335 aac cac atg acc gag cag ctt tcc atc gcc aaa gaa gca gac gag cgc 1056 Asn His Met Thr Glu Gln Leu Ser Ile Ala Lys Glu Ala Asp Glu Arg 340 345 350 aac cgc cgg cgc gag gaa gcc gcc aga cat tat ctc gaa tgc gtg ttg 1104 Asn Arg Arg Arg Glu Glu Ala Ala Arg His Tyr Leu Glu Cys Val Leu 355 360 365 gag ggg ctg acc acg ggc gtg gtg gtg ttt gac gaa caa ggc tgt ctg 1152 Glu Gly Leu Thr Thr Gly Val Val Val Phe Asp Glu Gln Gly Cys Leu 370 375 380 aaa acc ttc aac aaa gcg gcg gaa cag att ttg ggg atg ccg ctt acc 1200 Lys Thr Phe Asn Lys Ala Ala Glu Gln Ile Leu Gly Met Pro Leu Thr 385 390 395 400 ccc ctg tgg ggc agc agc cgg cac ggt tgg cac ggc gtt tcg gcg cag 1248 Pro Leu Trp Gly Ser Ser Arg His Gly Trp His Gly Val Ser Ala Gln 405 410 415 cag tcc ctg ctt gcc gaa gtg ttt gcc gcc atc ggc gcg gcg gca ggt 1296 Gln Ser Leu Leu Ala Glu Val Phe Ala Ala Ile Gly Ala Ala Ala Gly 420 425 430 acg gac aaa ccg gtc cat gtg aaa tat gcc gcg ccg gac gat gcc aaa 1344 Thr Asp Lys Pro Val His Val Lys Tyr Ala Ala Pro Asp Asp Ala Lys 435 440 445 atc ctg ctg ggc aag gca acc gtc ctg ccc gaa gac aac ggc aac ggc 1392 Ile Leu Leu Gly Lys Ala Thr Val Leu Pro Glu Asp Asn Gly Asn Gly 450 455 460 gtg gta atg gtg att gac gac atc acc gtt ttg ata cac gcg caa aaa 1440 Val Val Met Val Ile Asp Asp Ile Thr Val Leu Ile His Ala Gln Lys 465 470 475 480 gaa gcc gcg tgg ggc gaa gtg gca aaa cgg ctg gca cac gaa atc cgc 1488 Glu Ala Ala Trp Gly Glu Val Ala Lys Arg Leu Ala His Glu Ile Arg 485 490 495 aat ccg ctc acg ccc atc cag ctt tct gcc gaa cgg ctg gcg tgg aaa 1536 Asn Pro Leu Thr Pro Ile Gln Leu Ser Ala Glu Arg Leu Ala Trp Lys 500 505 510 ttg ggc ggg aag ctg gac gag cag gac gcg caa atc ctg aca cgt tcg 1584 Leu Gly Gly Lys Leu Asp Glu Gln Asp Ala Gln Ile Leu Thr Arg Ser 515 520 525 acc gac acc atc atc aaa caa gtg gcg gca tta aaa gaa atg gtc gag 1632 Thr Asp Thr Ile Ile Lys Gln Val Ala Ala Leu Lys Glu Met Val Glu 530 535 540 gca ttc cgc aat tac gcg cgt tcc cct tcg ctc aaa ttg gaa aat cag 1680 Ala Phe Arg Asn Tyr Ala Arg Ser Pro Ser Leu Lys Leu Glu Asn Gln 545 550 555 560 gat ttg aac gcc tta atc ggc gat gtg ttg gca ttg tac gaa gct ggt 1728 Asp Leu Asn Ala Leu Ile Gly Asp Val Leu Ala Leu Tyr Glu Ala Gly 565 570 575 ccg tgc cgg ttt gcg gcg gaa ctt gcc ggc gaa ccg ctg atg atg gcg 1776 Pro Cys Arg Phe Ala Ala Glu Leu Ala Gly Glu Pro Leu Met Met Ala 580 585 590 gcg gat acg acc gcc atg cgg cag gtg ctg cac aat att ttc aaa aat 1824 Ala Asp Thr Thr Ala Met Arg Gln Val Leu His Asn Ile Phe Lys Asn 595 600 605 gcc gcc gaa gcg gcg gaa gaa gcc gat gtg ccc gaa gtc agg gta aaa 1872 Ala Ala Glu Ala Ala Glu Glu Ala Asp Val Pro Glu Val Arg Val Lys 610 615 620 tcg gaa gcg ggg cag gac gga cgg att gtc ctg aca gtt tgc gac aac 1920 Ser Glu Ala Gly Gln Asp Gly Arg Ile Val Leu Thr Val Cys Asp Asn 625 630 635 640 ggc aag ggg ttc ggc agg gaa atg ctg cac aat gcc ttc gag ccg tat 1968 Gly Lys Gly Phe Gly Arg Glu Met Leu His Asn Ala Phe Glu Pro Tyr 645 650 655 gta acg gac aaa ccg gct gga acg gga ttg gga ctg ccc gtg gtg aaa 2016 Val Thr Asp Lys Pro Ala Gly Thr Gly Leu Gly Leu Pro Val Val Lys 660 665 670 aaa atc att gaa gaa cac ggc ggc cgc atc agc ctg agc aat cag gat 2064 Lys Ile Ile Glu Glu His Gly Gly Arg Ile Ser Leu Ser Asn Gln Asp 675 680 685 gcg ggc ggc gcg tgt gtc aga atc atc ttg cca aaa acg gta gaa act 2112 Ala Gly Gly Ala Cys Val Arg Ile Ile Leu Pro Lys Thr Val Glu Thr 690 695 700 tat gcg 2118 Tyr Ala 705 <210> 74 <211> 706 <212> PRT <213> Neisseria meningitidis <400> 74 Met Arg Arg Phe Leu Pro Ile Ala Ala Ile Cys Ala Val Val Leu Leu 1 5 10 15 Tyr Gly Leu Thr Ala Ala Thr Gly Ser Thr Ser Ser Leu Ala Asp Tyr 20 25 30 Phe Trp Trp Ile Val Ala Phe Ser Ala Met Leu Leu Leu Val Leu Ser 35 40 45 Ala Val Leu Ala Arg Tyr Val Ile Leu Leu Leu Lys Asp Arg Arg Asp 50 55 60 Gly Val Phe Gly Ser Gln Ile Ala Lys Arg Leu Ser Gly Met Phe Thr 65 70 75 80 Leu Val Ala Val Leu Pro Gly Val Phe Leu Phe Gly Val Ser Ala Gln 85 90 95 Phe Ile Asn Gly Thr Ile Asn Ser Trp Phe Gly Asn Asp Thr His Glu 100 105 110 Ala Leu Glu Arg Ser Leu Asn Leu Ser Lys Ser Ala Leu Asn Leu Ala 115 120 125 Ala Asp Asn Ala Leu Gly Asn Ala Ile Pro Val Gln Ile Asp Leu Ile 130 135 140 Gly Ala Ala Ser Leu Pro Gly Asp Met Gly Arg Val Leu Glu His Tyr 145 150 155 160 Ala Gly Ser Gly Phe Ala Gln Leu Ala Leu Tyr Asn Ala Ala Ser Gly 165 170 175 Lys Ile Glu Lys Ser Ile Asn Pro His Lys Leu Asp Gln Pro Phe Pro 180 185 190 Gly Lys Ala Arg Trp Glu Lys Ile Gln Gln Ala Gly Ser Val Arg Asp 195 200 205 Leu Glu Ser Ile Gly Gly Val Leu Tyr Ala Gln Gly Trp Leu Ser Ala 210 215 220 Gly Thr His Asn Gly Arg Asp Tyr Ala Leu Phe Phe Arg Gln Pro Val 225 230 235 240 Pro Lys Gly Val Ala Glu Asp Ala Val Leu Ile Glu Lys Ala Arg Ala 245 250 255 Lys Tyr Ala Glu Leu Ser Tyr Ser Lys Lys Gly Leu Gln Thr Phe Phe 260 265 270 Leu Ala Thr Leu Leu Ile Ala Ser Leu Leu Ser Ile Phe Leu Ala Leu 275 280 285 Val Met Ala Leu Tyr Phe Ala Arg Arg Phe Val Glu Pro Val Leu Ser 290 295 300 Leu Ala Glu Gly Ala Lys Ala Val Ala Gln Gly Asp Phe Ser Gln Thr 305 310 315 320 Arg Pro Val Leu Arg Asn Asp Glu Phe Gly Arg Leu Thr Lys Leu Phe 325 330 335 Asn His Met Thr Glu Gln Leu Ser Ile Ala Lys Glu Ala Asp Glu Arg 340 345 350 Asn Arg Arg Arg Glu Glu Ala Ala Arg His Tyr Leu Glu Cys Val Leu 355 360 365 Glu Gly Leu Thr Thr Gly Val Val Val Phe Asp Glu Gln Gly Cys Leu 370 375 380 Lys Thr Phe Asn Lys Ala Ala Glu Gln Ile Leu Gly Met Pro Leu Thr 385 390 395 400 Pro Leu Trp Gly Ser Ser Arg His Gly Trp His Gly Val Ser Ala Gln 405 410 415 Gln Ser Leu Leu Ala Glu Val Phe Ala Ala Ile Gly Ala Ala Ala Gly 420 425 430 Thr Asp Lys Pro Val His Val Lys Tyr Ala Ala Pro Asp Asp Ala Lys 435 440 445 Ile Leu Leu Gly Lys Ala Thr Val Leu Pro Glu Asp Asn Gly Asn Gly 450 455 460 Val Val Met Val Ile Asp Asp Ile Thr Val Leu Ile His Ala Gln Lys 465 470 475 480 Glu Ala Ala Trp Gly Glu Val Ala Lys Arg Leu Ala His Glu Ile Arg 485 490 495 Asn Pro Leu Thr Pro Ile Gln Leu Ser Ala Glu Arg Leu Ala Trp Lys 500 505 510 Leu Gly Gly Lys Leu Asp Glu Gln Asp Ala Gln Ile Leu Thr Arg Ser 515 520 525 Thr Asp Thr Ile Ile Lys Gln Val Ala Ala Leu Lys Glu Met Val Glu 530 535 540 Ala Phe Arg Asn Tyr Ala Arg Ser Pro Ser Leu Lys Leu Glu Asn Gln 545 550 555 560 Asp Leu Asn Ala Leu Ile Gly Asp Val Leu Ala Leu Tyr Glu Ala Gly 565 570 575 Pro Cys Arg Phe Ala Ala Glu Leu Ala Gly Glu Pro Leu Met Met Ala 580 585 590 Ala Asp Thr Thr Ala Met Arg Gln Val Leu His Asn Ile Phe Lys Asn 595 600 605 Ala Ala Glu Ala Ala Glu Glu Ala Asp Val Pro Glu Val Arg Val Lys 610 615 620 Ser Glu Ala Gly Gln Asp Gly Arg Ile Val Leu Thr Val Cys Asp Asn 625 630 635 640 Gly Lys Gly Phe Gly Arg Glu Met Leu His Asn Ala Phe Glu Pro Tyr 645 650 655 Val Thr Asp Lys Pro Ala Gly Thr Gly Leu Gly Leu Pro Val Val Lys 660 665 670 Lys Ile Ile Glu Glu His Gly Gly Arg Ile Ser Leu Ser Asn Gln Asp 675 680 685 Ala Gly Gly Ala Cys Val Arg Ile Ile Leu Pro Lys Thr Val Glu Thr 690 695 700 Tyr Ala 705 <210> 75 <211> 1686 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1686) <400> 75 atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag 48 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc 96 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac 144 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg 192 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att 240 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac 288 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg 336 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc 384 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc 432 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc 480 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt 528 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc 576 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att 624 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg 672 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg 720 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac 768 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg 816 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt 864 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc 912 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa 960 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa 1008 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc 1056 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga 1104 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg 1152 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg 1200 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc 1248 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg 1296 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc 1344 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg 1392 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac 1440 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg 1488 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg 1536 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc 1584 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga 1632 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc 1680 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 gta gca 1686 Val Ala <210> 76 <211> 562 <212> PRT <213> Neisseria meningitidis <400> 76 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 Val Ala <210> 77 <211> 1773 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1773) <400> 77 atg agt atc gtg ctg cac ggc gtg gcg gcg ggc aaa ggc att gcc gtc 48 Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val 1 5 10 15 ggt tgc gcc cac ctg att gcg cgc ggt acg gag gaa gtg ccg cag tat 96 Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr 20 25 30 gat gtt gcg gag gcg gac acc gat gcc gaa gcc gaa cgt ttc gat gcc 144 Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala 35 40 45 gcc gtc aaa gcc acg cgc aaa gag ttg gaa cag ctc cgc agc gcg att 192 Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile 50 55 60 ccc gaa aac gcc ccg acc gag ttg ggc gcg ttc atc tcg ctg cac ctg 240 Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu 65 70 75 80 atg ctc ttg acc gat gtt acc ttg tcg cgc gaa ccc gtc gat att tta 288 Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu 85 90 95 agg gaa caa aaa atc aac gcc gag tgg gca ttg aag cag cag agc gac 336 Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp 100 105 110 aaa ctc gcc gcc caa ttc gac aat atg gac gat gcc tat ttg cgc gaa 384 Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu 115 120 125 cgc aag cag gat atg ctg caa gtc gtc cgc cgc atc cac aac aac ctg 432 Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu 130 135 140 atc ggg cag ggc aac gag ttg gaa gtt gcc gac aac ctg ttt gac gaa 480 Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu 145 150 155 160 acc gtt ctg att gca aac gac ctt tcg ccc gcc gac acg gtt ttg ttt 528 Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe 165 170 175 aaa gag cag cgc att gcc gcc ttc gtt acc gat gcc ggc ggc ccc acc 576 Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr 180 185 190 ggg cat acg gcg att ttg ggc agg agc ttg gac atc ccg tcc gtc gtc 624 Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val 195 200 205 ggg ctg cac aac gcg cgc aaa ctg att acc gag ggc gaa acg gtc att 672 Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile 210 215 220 gtg gac ggt atc aac ggc gtg ttg att atc gcg ccg gat gag tcg gtg 720 Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val 225 230 235 240 ttg aac gaa tac cgc cgc cgt gcc cgc gaa tac cgc agc cac aaa cgc 768 Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg 245 250 255 gat ttg aac aag ctc aaa aaa acc gcc gcc gcc acc gct gac ggg gtc 816 Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val 260 265 270 tgc atc gag ctt gtg ggc aat ata gaa tcc gcc gaa gac gtg aaa ccg 864 Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro 275 280 285 ctg cac aac ctc ggc gca gac ggc atc ggg ctg ttc cgc agc gag ttt 912 Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe 290 295 300 ctt tac ctg aac cgc gat acg atg ccg tct gaa gac gag cag tac gaa 960 Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu 305 310 315 320 gtg tac agc gcg att gtc aaa aaa atg aaa ggc aaa agc gta acg ata 1008 Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile 325 330 335 cgg aca gtc gat ttg ggt gtg gac aaa aac ccg cgc tgg ttc ggg aaa 1056 Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys 340 345 350 aac agc acg ccc aac ggc agc ctc aac ccc gcg ctg ggc atg acc ggc 1104 Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly 355 360 365 atc cgc ctg tgc ctt gcc gaa ccg gtc atg ttc cgc acc cag atg cgc 1152 Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg 370 375 380 gcc atc ctc cgc gcc gcc gcc cac ggc ccc gtg cgg atg atg tgg ccg 1200 Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro 385 390 395 400 atg att acc tcc gta tcc gaa gtg cgc cag tgc ctc atc cac ctc gac 1248 Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp 405 410 415 acc gcg caa cgc cag ctt gcc gaa cgc ggc gat gcc ttc ggt aaa gtc 1296 Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val 420 425 430 ggc atc ggc tgt atg att gaa att ccg tct gcc gcg ctg acc gtc ggc 1344 Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly 435 440 445 agt att ttg aaa ctg gtc gat ttc atc tcc gtc ggt acc aac gac ctg 1392 Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu 450 455 460 att caa tac atc ttg tcc gtc gat cgc ggc gac gac agc gtc agc cac 1440 Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His 465 470 475 480 ctc tac cag ccc ggc cat ccc gcc gtg ctg aaa atg ctg caa cac gtc 1488 Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val 485 490 495 atc cgt acc gcc aac cgc atg gac aaa gac gta tcc gta tgc ggc gag 1536 Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu 500 505 510 atg gcg ggc gat acc gcg ttt acc cgc gtt tta ttg ggt atg ggg ctg 1584 Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu 515 520 525 cgc cgt ttt tcc atg aac ccc aac aac atc ctg ccc gtc aaa aac atc 1632 Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile 530 535 540 att ctg cac agc aat gtc gga cag ctc gaa agc gat att gtg aaa gtc 1680 Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val 545 550 555 560 atc cgc tgc gaa gac gaa gag aag tcg gaa aag ctg atc aaa cag atg 1728 Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met 565 570 575 aac agc gtg tct gtc gag gaa gaa gcc gac ttc aag ggg cgg aaa 1773 Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys 580 585 590 <210> 78 <211> 591 <212> PRT <213> Neisseria meningitidis <400> 78 Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val 1 5 10 15 Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr 20 25 30 Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala 35 40 45 Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile 50 55 60 Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu 65 70 75 80 Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu 85 90 95 Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp 100 105 110 Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu 115 120 125 Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu 130 135 140 Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu 145 150 155 160 Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe 165 170 175 Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr 180 185 190 Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val 195 200 205 Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile 210 215 220 Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val 225 230 235 240 Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg 245 250 255 Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val 260 265 270 Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro 275 280 285 Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe 290 295 300 Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu 305 310 315 320 Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile 325 330 335 Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys 340 345 350 Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly 355 360 365 Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg 370 375 380 Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro 385 390 395 400 Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp 405 410 415 Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val 420 425 430 Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly 435 440 445 Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu 450 455 460 Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His 465 470 475 480 Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val 485 490 495 Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu 500 505 510 Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu 515 520 525 Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile 530 535 540 Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val 545 550 555 560 Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met 565 570 575 Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys 580 585 590 <210> 79 <211> 1062 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1062) <400> 79 atg gaa aaa gaa ttc agg ata tta aat atc gta tcg gcc aag att tgg 48 Met Glu Lys Glu Phe Arg Ile Leu Asn Ile Val Ser Ala Lys Ile Trp 1 5 10 15 ggt gga ggc gaa caa tat gtc tat gat gtt tca aaa gca ttg ggg ctt 96 Gly Gly Gly Glu Gln Tyr Val Tyr Asp Val Ser Lys Ala Leu Gly Leu 20 25 30 cgg gac tgc aca atg ttt acc gcc gtc aat aaa aat aat gaa ttg atg 144 Arg Asp Cys Thr Met Phe Thr Ala Val Asn Lys Asn Asn Glu Leu Met 35 40 45 cac agg cga ttt tcc gaa gtt tct tcc gtt ttc acg aca cgc ctt cac 192 His Arg Arg Phe Ser Glu Val Ser Ser Val Phe Thr Thr Arg Leu His 50 55 60 acg ctc aac ggg ctg ttt tcg ctc tac gca ctt acc cgc ttt atc cgg 240 Thr Leu Asn Gly Leu Phe Ser Leu Tyr Ala Leu Thr Arg Phe Ile Arg 65 70 75 80 aaa aac cgc att tcc cac ctg atg ata cac acc ggc aaa att gcc gcc 288 Lys Asn Arg Ile Ser His Leu Met Ile His Thr Gly Lys Ile Ala Ala 85 90 95 tta tcc ata ctt ttg aaa aaa ctg acc ggg gtg cgc ctg ata ttt gtc 336 Leu Ser Ile Leu Leu Lys Lys Leu Thr Gly Val Arg Leu Ile Phe Val 100 105 110 aaa cat aat gtt gtc gcc aac aaa act gat ttt tat cac cgc ctg ata 384 Lys His Asn Val Val Ala Asn Lys Thr Asp Phe Tyr His Arg Leu Ile 115 120 125 cag aaa aac acc gac cgc ttt att tgc gtt tcc cgt ctg gtt tac gat 432 Gln Lys Asn Thr Asp Arg Phe Ile Cys Val Ser Arg Leu Val Tyr Asp 130 135 140 gtg caa acc gcc gac aat ccc ttt aaa gaa aaa tac cgg att gtt cat 480 Val Gln Thr Ala Asp Asn Pro Phe Lys Glu Lys Tyr Arg Ile Val His 145 150 155 160 aac ggt atc gat acc ggc cgt ttc cct ccc cct caa gaa aaa ccc gac 528 Asn Gly Ile Asp Thr Gly Arg Phe Pro Pro Pro Gln Glu Lys Pro Asp 165 170 175 agc cgt ttt ttt acc gtc gcc tac gcc ggc agg atc agt ccg gaa aaa 576 Ser Arg Phe Phe Thr Val Ala Tyr Ala Gly Arg Ile Ser Pro Glu Lys 180 185 190 gga ttg gaa aac ctg att gaa gcc tgt gtg ata ctg cat cgg aaa tat 624 Gly Leu Glu Asn Leu Ile Glu Ala Cys Val Ile Leu His Arg Lys Tyr 195 200 205 cct caa atc agg ctc aaa ttg gca ggg gac gga cat ccg gat tat atg 672 Pro Gln Ile Arg Leu Lys Leu Ala Gly Asp Gly His Pro Asp Tyr Met 210 215 220 tgt cgc ctg aag cgg gac gta tct gct tcg gga gca gaa cca ttt gtt 720 Cys Arg Leu Lys Arg Asp Val Ser Ala Ser Gly Ala Glu Pro Phe Val 225 230 235 240 tct ttt gaa ggg ttt acc gaa aaa ctt gct tcg ttt tac cgc caa agc 768 Ser Phe Glu Gly Phe Thr Glu Lys Leu Ala Ser Phe Tyr Arg Gln Ser 245 250 255 gat gtc gtg gtt ttg ccc agc ctc gtc ccg gag gca ttc ggt ttg tca 816 Asp Val Val Val Leu Pro Ser Leu Val Pro Glu Ala Phe Gly Leu Ser 260 265 270 tta tgc gag gcg atg tac tgc cga acg gcg gtg att tcc aat act ttg 864 Leu Cys Glu Ala Met Tyr Cys Arg Thr Ala Val Ile Ser Asn Thr Leu 275 280 285 ggc gcg caa aag gaa att atc gaa cat cat caa tcg ggg att ctg ctg 912 Gly Ala Gln Lys Glu Ile Ile Glu His His Gln Ser Gly Ile Leu Leu 290 295 300 gat agg ctg aca cct gaa tct ttg gcg gac gaa atc gaa cgc ctc gtc 960 Asp Arg Leu Thr Pro Glu Ser Leu Ala Asp Glu Ile Glu Arg Leu Val 305 310 315 320 tta aac cct gaa acg aaa aac gca ctg gca acg gca gga cat caa tgc 1008 Leu Asn Pro Glu Thr Lys Asn Ala Leu Ala Thr Ala Gly His Gln Cys 325 330 335 gtc gcc aac cgt ttt acc atc aac cat acc gcc gac aaa tta ttg gat 1056 Val Ala Asn Arg Phe Thr Ile Asn His Thr Ala Asp Lys Leu Leu Asp 340 345 350 gca ata 1062 Ala Ile <210> 80 <211> 354 <212> PRT <213> Neisseria meningitidis <400> 80 Met Glu Lys Glu Phe Arg Ile Leu Asn Ile Val Ser Ala Lys Ile Trp 1 5 10 15 Gly Gly Gly Glu Gln Tyr Val Tyr Asp Val Ser Lys Ala Leu Gly Leu 20 25 30 Arg Asp Cys Thr Met Phe Thr Ala Val Asn Lys Asn Asn Glu Leu Met 35 40 45 His Arg Arg Phe Ser Glu Val Ser Ser Val Phe Thr Thr Arg Leu His 50 55 60 Thr Leu Asn Gly Leu Phe Ser Leu Tyr Ala Leu Thr Arg Phe Ile Arg 65 70 75 80 Lys Asn Arg Ile Ser His Leu Met Ile His Thr Gly Lys Ile Ala Ala 85 90 95 Leu Ser Ile Leu Leu Lys Lys Leu Thr Gly Val Arg Leu Ile Phe Val 100 105 110 Lys His Asn Val Val Ala Asn Lys Thr Asp Phe Tyr His Arg Leu Ile 115 120 125 Gln Lys Asn Thr Asp Arg Phe Ile Cys Val Ser Arg Leu Val Tyr Asp 130 135 140 Val Gln Thr Ala Asp Asn Pro Phe Lys Glu Lys Tyr Arg Ile Val His 145 150 155 160 Asn Gly Ile Asp Thr Gly Arg Phe Pro Pro Pro Gln Glu Lys Pro Asp 165 170 175 Ser Arg Phe Phe Thr Val Ala Tyr Ala Gly Arg Ile Ser Pro Glu Lys 180 185 190 Gly Leu Glu Asn Leu Ile Glu Ala Cys Val Ile Leu His Arg Lys Tyr 195 200 205 Pro Gln Ile Arg Leu Lys Leu Ala Gly Asp Gly His Pro Asp Tyr Met 210 215 220 Cys Arg Leu Lys Arg Asp Val Ser Ala Ser Gly Ala Glu Pro Phe Val 225 230 235 240 Ser Phe Glu Gly Phe Thr Glu Lys Leu Ala Ser Phe Tyr Arg Gln Ser 245 250 255 Asp Val Val Val Leu Pro Ser Leu Val Pro Glu Ala Phe Gly Leu Ser 260 265 270 Leu Cys Glu Ala Met Tyr Cys Arg Thr Ala Val Ile Ser Asn Thr Leu 275 280 285 Gly Ala Gln Lys Glu Ile Ile Glu His His Gln Ser Gly Ile Leu Leu 290 295 300 Asp Arg Leu Thr Pro Glu Ser Leu Ala Asp Glu Ile Glu Arg Leu Val 305 310 315 320 Leu Asn Pro Glu Thr Lys Asn Ala Leu Ala Thr Ala Gly His Gln Cys 325 330 335 Val Ala Asn Arg Phe Thr Ile Asn His Thr Ala Asp Lys Leu Leu Asp 340 345 350 Ala Ile <210> 81 <211> 795 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(795) <400> 81 atg gcg gct gtt ttt tct gta tgt gcc tgt ttt atg tgt tcc tgc ctt 48 Met Ala Ala Val Phe Ser Val Cys Ala Cys Phe Met Cys Ser Cys Leu 1 5 10 15 gtt gtc aaa aat acc gtt atc gga agc gga cgc acc aaa atc gcc gtg 96 Val Val Lys Asn Thr Val Ile Gly Ser Gly Arg Thr Lys Ile Ala Val 20 25 30 ccg ctt gtc gcc cgc gat gcc gcc gta ctt tcc gcc gta ctt gac caa 144 Pro Leu Val Ala Arg Asp Ala Ala Val Leu Ser Ala Val Leu Asp Gln 35 40 45 atc aaa aac ctg ccc ttc gat atc gtc gag ttc cgc gcc gat ttt ttg 192 Ile Lys Asn Leu Pro Phe Asp Ile Val Glu Phe Arg Ala Asp Phe Leu 50 55 60 gaa tgc gcg ggc agc atc ggc gaa gta ttg cgc cac acg cag acc gtc 240 Glu Cys Ala Gly Ser Ile Gly Glu Val Leu Arg His Thr Gln Thr Val 65 70 75 80 cgc gac gcg cta ccc gac aag ccg ctg ctg ttt acg ttc aga cgg cat 288 Arg Asp Ala Leu Pro Asp Lys Pro Leu Leu Phe Thr Phe Arg Arg His 85 90 95 ggc gaa ggc ggc tcg ttc ccg tgt tcg gac gat tat tat ttt gaa ctg 336 Gly Glu Gly Gly Ser Phe Pro Cys Ser Asp Asp Tyr Tyr Phe Glu Leu 100 105 110 ctc gac gcg ctg atc gaa agc cgc ctg ccc gac atc atc gac atc gag 384 Leu Asp Ala Leu Ile Glu Ser Arg Leu Pro Asp Ile Ile Asp Ile Glu 115 120 125 ctg ttt tcc ggc gaa acc gcc gtc cgg tgc gcc gtg gca aat gct caa 432 Leu Phe Ser Gly Glu Thr Ala Val Arg Cys Ala Val Ala Asn Ala Gln 130 135 140 aaa aac ggc atc gcc gcc ctg ctc tgc aat cat gag ttt cac cgc acg 480 Lys Asn Gly Ile Ala Ala Leu Leu Cys Asn His Glu Phe His Arg Thr 145 150 155 160 ccg ccg caa gaa gaa atc gta tgc cgt ctg aaa cag atg gag gac tgc 528 Pro Pro Gln Glu Glu Ile Val Cys Arg Leu Lys Gln Met Glu Asp Cys 165 170 175 ggc gcg gac atc tgc aaa att gcg gtg atg ccg caa agc gcg gaa gat 576 Gly Ala Asp Ile Cys Lys Ile Ala Val Met Pro Gln Ser Ala Glu Asp 180 185 190 gtg ctg act ttg ctt tcc gcc acg ctc aaa gcg aaa gag ctt gcc gcc 624 Val Leu Thr Leu Leu Ser Ala Thr Leu Lys Ala Lys Glu Leu Ala Ala 195 200 205 aaa ccg att gtt acg atg tcg atg ggg cag acg ggg gcg gtc agc cgg 672 Lys Pro Ile Val Thr Met Ser Met Gly Gln Thr Gly Ala Val Ser Arg 210 215 220 ctt gcc gga cag gtg ttc ggc tca agc atc acg ttc ggt tcg gga acg 720 Leu Ala Gly Gln Val Phe Gly Ser Ser Ile Thr Phe Gly Ser Gly Thr 225 230 235 240 caa aac tcc gcg ccg ggg caa atc ggc gta tcc gcc ctc cgt gcg aca 768 Gln Asn Ser Ala Pro Gly Gln Ile Gly Val Ser Ala Leu Arg Ala Thr 245 250 255 ctc gac tgc ctc gaa aac gga gca gac 795 Leu Asp Cys Leu Glu Asn Gly Ala Asp 260 265 <210> 82 <211> 265 <212> PRT <213> Neisseria meningitidis <400> 82 Met Ala Ala Val Phe Ser Val Cys Ala Cys Phe Met Cys Ser Cys Leu 1 5 10 15 Val Val Lys Asn Thr Val Ile Gly Ser Gly Arg Thr Lys Ile Ala Val 20 25 30 Pro Leu Val Ala Arg Asp Ala Ala Val Leu Ser Ala Val Leu Asp Gln 35 40 45 Ile Lys Asn Leu Pro Phe Asp Ile Val Glu Phe Arg Ala Asp Phe Leu 50 55 60 Glu Cys Ala Gly Ser Ile Gly Glu Val Leu Arg His Thr Gln Thr Val 65 70 75 80 Arg Asp Ala Leu Pro Asp Lys Pro Leu Leu Phe Thr Phe Arg Arg His 85 90 95 Gly Glu Gly Gly Ser Phe Pro Cys Ser Asp Asp Tyr Tyr Phe Glu Leu 100 105 110 Leu Asp Ala Leu Ile Glu Ser Arg Leu Pro Asp Ile Ile Asp Ile Glu 115 120 125 Leu Phe Ser Gly Glu Thr Ala Val Arg Cys Ala Val Ala Asn Ala Gln 130 135 140 Lys Asn Gly Ile Ala Ala Leu Leu Cys Asn His Glu Phe His Arg Thr 145 150 155 160 Pro Pro Gln Glu Glu Ile Val Cys Arg Leu Lys Gln Met Glu Asp Cys 165 170 175 Gly Ala Asp Ile Cys Lys Ile Ala Val Met Pro Gln Ser Ala Glu Asp 180 185 190 Val Leu Thr Leu Leu Ser Ala Thr Leu Lys Ala Lys Glu Leu Ala Ala 195 200 205 Lys Pro Ile Val Thr Met Ser Met Gly Gln Thr Gly Ala Val Ser Arg 210 215 220 Leu Ala Gly Gln Val Phe Gly Ser Ser Ile Thr Phe Gly Ser Gly Thr 225 230 235 240 Gln Asn Ser Ala Pro Gly Gln Ile Gly Val Ser Ala Leu Arg Ala Thr 245 250 255 Leu Asp Cys Leu Glu Asn Gly Ala Asp 260 265 <210> 83 <211> 876 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(876) <400> 83 ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc 48 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat 96 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac 144 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg 192 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg 240 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa 288 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc 336 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc 384 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg 432 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa 480 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa 528 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat 576 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc 624 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac 672 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc 720 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg 768 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa 816 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc 864 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 cat aaa aaa gac 876 His Lys Lys Asp 290 <210> 84 <211> 292 <212> PRT <213> Neisseria meningitidis <400> 84 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 His Lys Lys Asp 290 <210> 85 <211> 1545 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1545) <400> 85 gtg cgt ctc aat cat ttc ata atg ata gcg att att ata tat gtg att 48 Val Arg Leu Asn His Phe Ile Met Ile Ala Ile Ile Ile Tyr Val Ile 1 5 10 15 tcc cct gca aac aag ccg gcc cgc cgc cac agc gtt ccc act tat ccg 96 Ser Pro Ala Asn Lys Pro Ala Arg Arg His Ser Val Pro Thr Tyr Pro 20 25 30 gct ttg cct tat aat tgc ttt ttt tat gta aca gat tta cct atg aat 144 Ala Leu Pro Tyr Asn Cys Phe Phe Tyr Val Thr Asp Leu Pro Met Asn 35 40 45 ttc ccc aaa aca gcg gcc tcc ctg ctg ctg ctt ctc gcc tcc ctc gcc 192 Phe Pro Lys Thr Ala Ala Ser Leu Leu Leu Leu Leu Ala Ser Leu Ala 50 55 60 gca cac gcg ctc gat aca ggt cgc att ccg caa aac gaa atc gcc gta 240 Ala His Ala Leu Asp Thr Gly Arg Ile Pro Gln Asn Glu Ile Ala Val 65 70 75 80 tat gtc caa gag ctt gac agc gga aaa gtc atc att gac cac cgc tcg 288 Tyr Val Gln Glu Leu Asp Ser Gly Lys Val Ile Ile Asp His Arg Ser 85 90 95 gat gtc ccc gtc aac ccc gcc tcc aca atg aaa ctc gtt acc gcg ttt 336 Asp Val Pro Val Asn Pro Ala Ser Thr Met Lys Leu Val Thr Ala Phe 100 105 110 gcc gcc ttc aaa acc ttc ggc agc aat tac cgc tgg gcg acc gag ttt 384 Ala Ala Phe Lys Thr Phe Gly Ser Asn Tyr Arg Trp Ala Thr Glu Phe 115 120 125 aaa agc aac ggt acg gta aac gac ggc acg ctt gac gga aac ctg tat 432 Lys Ser Asn Gly Thr Val Asn Asp Gly Thr Leu Asp Gly Asn Leu Tyr 130 135 140 tgg gcg ggc agc ggc gac ccc gtt ttc aat cag gaa aac ctg ctt gcc 480 Trp Ala Gly Ser Gly Asp Pro Val Phe Asn Gln Glu Asn Leu Leu Ala 145 150 155 160 gtc caa cgc cag ttg cgc gaa caa ggc ata cgc aat atc acg gga cac 528 Val Gln Arg Gln Leu Arg Glu Gln Gly Ile Arg Asn Ile Thr Gly His 165 170 175 ctg atg ctc gac cac agc ctg tgg ggc gaa gtc ggc agc ccc gac gat 576 Leu Met Leu Asp His Ser Leu Trp Gly Glu Val Gly Ser Pro Asp Asp 180 185 190 ttc gaa gcc gac agc ggt tcg ccg ttt atg acg ccc ccc aat cca act 624 Phe Glu Ala Asp Ser Gly Ser Pro Phe Met Thr Pro Pro Asn Pro Thr 195 200 205 atg ctg tct gcc ggt atg gtt atg gtg cgc gcc gaa cgc aat gcc gcc 672 Met Leu Ser Ala Gly Met Val Met Val Arg Ala Glu Arg Asn Ala Ala 210 215 220 gac agt acc gac atc ctc acc gat ccg cct ttg ccg cat att ttc gcc 720 Asp Ser Thr Asp Ile Leu Thr Asp Pro Pro Leu Pro His Ile Phe Ala 225 230 235 240 caa aac aac ttg aaa att acc gcc tcc caa gct gcc tgc cct tcg atc 768 Gln Asn Asn Leu Lys Ile Thr Ala Ser Gln Ala Ala Cys Pro Ser Ile 245 250 255 aaa aaa ctg atg cgt gca tct ttt tcg gac aat acg ctg aaa ttg cgc 816 Lys Lys Leu Met Arg Ala Ser Phe Ser Asp Asn Thr Leu Lys Leu Arg 260 265 270 ggc aat att ccc gag agc tgt ttg ggc aag cct gtc ggt gtc cgg atg 864 Gly Asn Ile Pro Glu Ser Cys Leu Gly Lys Pro Val Gly Val Arg Met 275 280 285 ttc gcg ctt gac gaa ctg atc cgg caa agt ttt acc aac cac tgg ctg 912 Phe Ala Leu Asp Glu Leu Ile Arg Gln Ser Phe Thr Asn His Trp Leu 290 295 300 ctc ggc ggc gga cgg att tca gac ggc atc ggc ata tcc gac acg ccg 960 Leu Gly Gly Gly Arg Ile Ser Asp Gly Ile Gly Ile Ser Asp Thr Pro 305 310 315 320 gaa ggc gcg cag acg ctt gcc gtt gca cac tca aag ccg atg aag gaa 1008 Glu Gly Ala Gln Thr Leu Ala Val Ala His Ser Lys Pro Met Lys Glu 325 330 335 att ttg acg gac atg aac aag cgt tcg gac aat cta att gcg cgt tcc 1056 Ile Leu Thr Asp Met Asn Lys Arg Ser Asp Asn Leu Ile Ala Arg Ser 340 345 350 gtc ttc ctc aaa ctc ggc ggc gac ggc aaa ctg ccc gcc gtt tcc gaa 1104 Val Phe Leu Lys Leu Gly Gly Asp Gly Lys Leu Pro Ala Val Ser Glu 355 360 365 cag gca gcg tct gcc gtc cgg cgt gaa ctt gcc gtg tcg ggc atc gat 1152 Gln Ala Ala Ser Ala Val Arg Arg Glu Leu Ala Val Ser Gly Ile Asp 370 375 380 gtt gcg gat ttg gtt ttg gaa aac ggt tca ggt ctg tcc aga aaa gaa 1200 Val Ala Asp Leu Val Leu Glu Asn Gly Ser Gly Leu Ser Arg Lys Glu 385 390 395 400 agg gta acg gcg aga atg atg gcg caa atg ttg gaa acg gct tat ttc 1248 Arg Val Thr Ala Arg Met Met Ala Gln Met Leu Glu Thr Ala Tyr Phe 405 410 415 agc ccg ttt gca caa gat ttc atc gat acg ctg ccc atc gcc ggc aca 1296 Ser Pro Phe Ala Gln Asp Phe Ile Asp Thr Leu Pro Ile Ala Gly Thr 420 425 430 gac ggg act tta cgc aac cgc ttc aaa caa agc ggc ggg ctg ttg cgc 1344 Asp Gly Thr Leu Arg Asn Arg Phe Lys Gln Ser Gly Gly Leu Leu Arg 435 440 445 tta aaa acc ggc acg ctc aac aat gtc cgc gcc ctt gca ggt tat tgg 1392 Leu Lys Thr Gly Thr Leu Asn Asn Val Arg Ala Leu Ala Gly Tyr Trp 450 455 460 ctg ggc gac aaa ccg atg gcg gtg gtc gtc atc atc aac agc ggc cgc 1440 Leu Gly Asp Lys Pro Met Ala Val Val Val Ile Ile Asn Ser Gly Arg 465 470 475 480 gcc gtt tcc ctg ctg ccc gac ttg gac aac ttc gtt gcc aac aac atc 1488 Ala Val Ser Leu Leu Pro Asp Leu Asp Asn Phe Val Ala Asn Asn Ile 485 490 495 atc tcc ggc ggc gat ggc tgg ctg gat gcg aaa ctg atg tgc aaa gaa 1536 Ile Ser Gly Gly Asp Gly Trp Leu Asp Ala Lys Leu Met Cys Lys Glu 500 505 510 cgc cga gcc 1545 Arg Arg Ala 515 <210> 86 <211> 515 <212> PRT <213> Neisseria meningitidis <400> 86 Val Arg Leu Asn His Phe Ile Met Ile Ala Ile Ile Ile Tyr Val Ile 1 5 10 15 Ser Pro Ala Asn Lys Pro Ala Arg Arg His Ser Val Pro Thr Tyr Pro 20 25 30 Ala Leu Pro Tyr Asn Cys Phe Phe Tyr Val Thr Asp Leu Pro Met Asn 35 40 45 Phe Pro Lys Thr Ala Ala Ser Leu Leu Leu Leu Leu Ala Ser Leu Ala 50 55 60 Ala His Ala Leu Asp Thr Gly Arg Ile Pro Gln Asn Glu Ile Ala Val 65 70 75 80 Tyr Val Gln Glu Leu Asp Ser Gly Lys Val Ile Ile Asp His Arg Ser 85 90 95 Asp Val Pro Val Asn Pro Ala Ser Thr Met Lys Leu Val Thr Ala Phe 100 105 110 Ala Ala Phe Lys Thr Phe Gly Ser Asn Tyr Arg Trp Ala Thr Glu Phe 115 120 125 Lys Ser Asn Gly Thr Val Asn Asp Gly Thr Leu Asp Gly Asn Leu Tyr 130 135 140 Trp Ala Gly Ser Gly Asp Pro Val Phe Asn Gln Glu Asn Leu Leu Ala 145 150 155 160 Val Gln Arg Gln Leu Arg Glu Gln Gly Ile Arg Asn Ile Thr Gly His 165 170 175 Leu Met Leu Asp His Ser Leu Trp Gly Glu Val Gly Ser Pro Asp Asp 180 185 190 Phe Glu Ala Asp Ser Gly Ser Pro Phe Met Thr Pro Pro Asn Pro Thr 195 200 205 Met Leu Ser Ala Gly Met Val Met Val Arg Ala Glu Arg Asn Ala Ala 210 215 220 Asp Ser Thr Asp Ile Leu Thr Asp Pro Pro Leu Pro His Ile Phe Ala 225 230 235 240 Gln Asn Asn Leu Lys Ile Thr Ala Ser Gln Ala Ala Cys Pro Ser Ile 245 250 255 Lys Lys Leu Met Arg Ala Ser Phe Ser Asp Asn Thr Leu Lys Leu Arg 260 265 270 Gly Asn Ile Pro Glu Ser Cys Leu Gly Lys Pro Val Gly Val Arg Met 275 280 285 Phe Ala Leu Asp Glu Leu Ile Arg Gln Ser Phe Thr Asn His Trp Leu 290 295 300 Leu Gly Gly Gly Arg Ile Ser Asp Gly Ile Gly Ile Ser Asp Thr Pro 305 310 315 320 Glu Gly Ala Gln Thr Leu Ala Val Ala His Ser Lys Pro Met Lys Glu 325 330 335 Ile Leu Thr Asp Met Asn Lys Arg Ser Asp Asn Leu Ile Ala Arg Ser 340 345 350 Val Phe Leu Lys Leu Gly Gly Asp Gly Lys Leu Pro Ala Val Ser Glu 355 360 365 Gln Ala Ala Ser Ala Val Arg Arg Glu Leu Ala Val Ser Gly Ile Asp 370 375 380 Val Ala Asp Leu Val Leu Glu Asn Gly Ser Gly Leu Ser Arg Lys Glu 385 390 395 400 Arg Val Thr Ala Arg Met Met Ala Gln Met Leu Glu Thr Ala Tyr Phe 405 410 415 Ser Pro Phe Ala Gln Asp Phe Ile Asp Thr Leu Pro Ile Ala Gly Thr 420 425 430 Asp Gly Thr Leu Arg Asn Arg Phe Lys Gln Ser Gly Gly Leu Leu Arg 435 440 445 Leu Lys Thr Gly Thr Leu Asn Asn Val Arg Ala Leu Ala Gly Tyr Trp 450 455 460 Leu Gly Asp Lys Pro Met Ala Val Val Val Ile Ile Asn Ser Gly Arg 465 470 475 480 Ala Val Ser Leu Leu Pro Asp Leu Asp Asn Phe Val Ala Asn Asn Ile 485 490 495 Ile Ser Gly Gly Asp Gly Trp Leu Asp Ala Lys Leu Met Cys Lys Glu 500 505 510 Arg Arg Ala 515 <210> 87 <211> 840 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(840) <400> 87 atg gat aaa gaa cga att tta acc ccc gca gtc gtg ttt tcc gtc gca 48 Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala 1 5 10 15 ctg ctg cat ttg gca atg gtg gca ttg ctc tgg cag gcg cac aag ctg 96 Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu 20 25 30 ccc gtg ata gag tca ggc aat gtt att gaa ttt gtc gat ttg ggc gat 144 Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp 35 40 45 ttt ggc gga ggg gac ggc gca ccc gaa ggt gca ggc gcg cct gcc gcg 192 Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala 50 55 60 ccc gaa ccg caa ccc gtg ccc gag ccg ccc aaa cct gtc gag ccg ccc 240 Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro 65 70 75 80 aag ccg gtt ttg aag ccg gtg gtt acg aaa aag gcg gat gcg gat att 288 Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile 85 90 95 cag cag cct aag gaa gag ccg aaa cct gaa gaa aag ccg aaa ccc gaa 336 Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu 100 105 110 gaa aaa ccg aaa cca gag cct aag ccg gaa gcg aag cct gtc ccg aaa 384 Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys 115 120 125 ccg gcg gaa aaa ccg gtc gag aag ccg tct gaa aaa cct gcc gaa cat 432 Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His 130 135 140 ccc ggc aat gct tct gcc aaa gca gac agc gag cag ggc aat ggg gaa 480 Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu 145 150 155 160 gat aag gga acc ggt atc aaa gga gac gga acg ggg cgc gga gaa ggc 528 Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly 165 170 175 agc ggt aaa ggt agc ggc ggt gtc aaa ggc gaa cac ggg gaa gga gcc 576 Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala 180 185 190 ggc agc agc aaa ggc aat cct tta cgc gcc aac ggc agc att ccg cgc 624 Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg 195 200 205 ccg gct tat ccc acg ctt tct atg gag aat gat gag cag ggt acg gtt 672 Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val 210 215 220 gtt ttg agc gtt ttg gtt tct ccg ggc ggt cat gtt gag tcc gtt aaa 720 Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys 225 230 235 240 atc gtg aaa agc agt ggt ttt tcc cgg ttg gac aat gcg gca cgc aag 768 Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys 245 250 255 gcg gcg caa aac ggg cat ttt caa gcc aat gcc tgg acg gag ttt aaa 816 Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys 260 265 270 gtc ccc gtc aag ttt gaa ttg aat 840 Val Pro Val Lys Phe Glu Leu Asn 275 280 <210> 88 <211> 280 <212> PRT <213> Neisseria meningitidis <400> 88 Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala 1 5 10 15 Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu 20 25 30 Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp 35 40 45 Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala 50 55 60 Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro 65 70 75 80 Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile 85 90 95 Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu 100 105 110 Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys 115 120 125 Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His 130 135 140 Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu 145 150 155 160 Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly 165 170 175 Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala 180 185 190 Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg 195 200 205 Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val 210 215 220 Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys 225 230 235 240 Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys 245 250 255 Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys 260 265 270 Val Pro Val Lys Phe Glu Leu Asn 275 280 <210> 89 <211> 1584 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1584) <400> 89 atg gca ctt ttc ctc agc ata ttc ccc atc gtc ctg ctg att tgg ctg 48 Met Ala Leu Phe Leu Ser Ile Phe Pro Ile Val Leu Leu Ile Trp Leu 1 5 10 15 atg gtg aaa aaa aac agt atg ccc tcc tac gtc gcg ctg ccg att acc 96 Met Val Lys Lys Asn Ser Met Pro Ser Tyr Val Ala Leu Pro Ile Thr 20 25 30 gca gtg ctg att tac gcc atc aaa ctt ttc tac ttc gac gat gcg ggc 144 Ala Val Leu Ile Tyr Ala Ile Lys Leu Phe Tyr Phe Asp Asp Ala Gly 35 40 45 atg ctg ctc aac gcc acc gcc gct tcc ggc ctc gtc aaa acg ctc acg 192 Met Leu Leu Asn Ala Thr Ala Ala Ser Gly Leu Val Lys Thr Leu Thr 50 55 60 ccg att acc gtg att ttc ggc gcg att atg ttc aac cgt atg atg gaa 240 Pro Ile Thr Val Ile Phe Gly Ala Ile Met Phe Asn Arg Met Met Glu 65 70 75 80 acc acg ggc tgc atc gat gtc atc cgc aaa tgg ctg gcg acc atc agc 288 Thr Thr Gly Cys Ile Asp Val Ile Arg Lys Trp Leu Ala Thr Ile Ser 85 90 95 ccc aac ccc gta gcg caa ctg atg att atc ggc tgg gct ttt gcc ttt 336 Pro Asn Pro Val Ala Gln Leu Met Ile Ile Gly Trp Ala Phe Ala Phe 100 105 110 atg att gaa ggc gca tcc ggc ttc ggc acg cct gcc gcg att gcc gcg 384 Met Ile Glu Gly Ala Ser Gly Phe Gly Thr Pro Ala Ala Ile Ala Ala 115 120 125 ccg att ctg atg agc ttg ggc ttc aac ccg ttg aaa gtg gcg att ttc 432 Pro Ile Leu Met Ser Leu Gly Phe Asn Pro Leu Lys Val Ala Ile Phe 130 135 140 act ttg gtg atg aac tcc gtc ccc gtc tct ttc ggc gcg gtc ggt acg 480 Thr Leu Val Met Asn Ser Val Pro Val Ser Phe Gly Ala Val Gly Thr 145 150 155 160 ccg acc tgg ttc ggt ttc gca ccg ctg aac ctg agt gcc gaa gac atc 528 Pro Thr Trp Phe Gly Phe Ala Pro Leu Asn Leu Ser Ala Glu Asp Ile 165 170 175 ctc gcc atc ggc agg cag acc ggc gta atg cac ttc ttc gca ggt ttc 576 Leu Ala Ile Gly Arg Gln Thr Gly Val Met His Phe Phe Ala Gly Phe 180 185 190 gtc atc ccc gtc atc ggc ttg ggc ttc atc gta cct tgg tct gaa atc 624 Val Ile Pro Val Ile Gly Leu Gly Phe Ile Val Pro Trp Ser Glu Ile 195 200 205 cgc aaa aac ttg ggc ttc gtc gcc att gcc gtc ttc tcc tgc acc att 672 Arg Lys Asn Leu Gly Phe Val Ala Ile Ala Val Phe Ser Cys Thr Ile 210 215 220 cct tat gtc gca ttg gcg atg gtc aac gaa gaa ttc ccg tcg ctc gtc 720 Pro Tyr Val Ala Leu Ala Met Val Asn Glu Glu Phe Pro Ser Leu Val 225 230 235 240 gcc ggc gcg atc ggc ctg atg gtg tcc gta ttc gcc gcc aac caa ggc 768 Ala Gly Ala Ile Gly Leu Met Val Ser Val Phe Ala Ala Asn Gln Gly 245 250 255 tgg ggc ttg agc aaa gac cac gcc aaa gac ccg aat gcc gaa aaa gtg 816 Trp Gly Leu Ser Lys Asp His Ala Lys Asp Pro Asn Ala Glu Lys Val 260 265 270 ccg ttc gcc caa gtc gcc aaa gca ctc gcc cct ttg ggt atg ctg atc 864 Pro Phe Ala Gln Val Ala Lys Ala Leu Ala Pro Leu Gly Met Leu Ile 275 280 285 ggc atg ctg gtg gtt acg cgc atc aaa cag ctc ggc atc aaa ggc att 912 Gly Met Leu Val Val Thr Arg Ile Lys Gln Leu Gly Ile Lys Gly Ile 290 295 300 ttg acc agc aaa gaa gaa tgg ttc agc ttc caa ctg ccg ttt gat ttg 960 Leu Thr Ser Lys Glu Glu Trp Phe Ser Phe Gln Leu Pro Phe Asp Leu 305 310 315 320 tcc aaa atc acc gtc agc gac tcc ctg acg att act ttc ggc aat att 1008 Ser Lys Ile Thr Val Ser Asp Ser Leu Thr Ile Thr Phe Gly Asn Ile 325 330 335 ttc gga caa gat gtc agc gcg tct tac caa acg ctg tac gtc ccg gct 1056 Phe Gly Gln Asp Val Ser Ala Ser Tyr Gln Thr Leu Tyr Val Pro Ala 340 345 350 tgg att ccg ttt gtg ctg acc gtt tgg att tgc atc ctg ctg tat aaa 1104 Trp Ile Pro Phe Val Leu Thr Val Trp Ile Cys Ile Leu Leu Tyr Lys 355 360 365 acc aaa ttc aaa gat gcc tgg acg att tat tcc gta act ttc aat caa 1152 Thr Lys Phe Lys Asp Ala Trp Thr Ile Tyr Ser Val Thr Phe Asn Gln 370 375 380 acc aaa aaa ccg ctg ctt gcc ctg atg ggc gcg ctg att atg gtt cag 1200 Thr Lys Lys Pro Leu Leu Ala Leu Met Gly Ala Leu Ile Met Val Gln 385 390 395 400 ctg atg ctg gtc ggc ggc gac aat tcg atg gtg aaa atc atc ggt aag 1248 Leu Met Leu Val Gly Gly Asp Asn Ser Met Val Lys Ile Ile Gly Lys 405 410 415 gaa ttt gcc gca atg gcg ggc gaa cac tgg gtt tat ttc tcg ccg tat 1296 Glu Phe Ala Ala Met Ala Gly Glu His Trp Val Tyr Phe Ser Pro Tyr 420 425 430 ctg ggc gcg atc ggt gcg ttc ttc tcc ggt tcc aac acc gtg tcc aac 1344 Leu Gly Ala Ile Gly Ala Phe Phe Ser Gly Ser Asn Thr Val Ser Asn 435 440 445 ctg acc ttc ggc ccg att cag cag caa atc gcc ttg gat acc ggc ctg 1392 Leu Thr Phe Gly Pro Ile Gln Gln Gln Ile Ala Leu Asp Thr Gly Leu 450 455 460 tcc gtt acc ctg att ctg gcg ttg cag tcc gtc ggc ggc gcg atg ggc 1440 Ser Val Thr Leu Ile Leu Ala Leu Gln Ser Val Gly Gly Ala Met Gly 465 470 475 480 aat atg gtg tgc ctc aac aac atc atc gcc gta tgt acc gta ttg gat 1488 Asn Met Val Cys Leu Asn Asn Ile Ile Ala Val Cys Thr Val Leu Asp 485 490 495 gtg aaa aat tcc gaa ggt gcg att atc aag aaa acc gtt atc ccg atg 1536 Val Lys Asn Ser Glu Gly Ala Ile Ile Lys Lys Thr Val Ile Pro Met 500 505 510 gcg att tac ggc gtg att gcc gtc gtc gcg gca atg att ttc ttc ctc 1584 Ala Ile Tyr Gly Val Ile Ala Val Val Ala Ala Met Ile Phe Phe Leu 515 520 525 <210> 90 <211> 528 <212> PRT <213> Neisseria meningitidis <400> 90 Met Ala Leu Phe Leu Ser Ile Phe Pro Ile Val Leu Leu Ile Trp Leu 1 5 10 15 Met Val Lys Lys Asn Ser Met Pro Ser Tyr Val Ala Leu Pro Ile Thr 20 25 30 Ala Val Leu Ile Tyr Ala Ile Lys Leu Phe Tyr Phe Asp Asp Ala Gly 35 40 45 Met Leu Leu Asn Ala Thr Ala Ala Ser Gly Leu Val Lys Thr Leu Thr 50 55 60 Pro Ile Thr Val Ile Phe Gly Ala Ile Met Phe Asn Arg Met Met Glu 65 70 75 80 Thr Thr Gly Cys Ile Asp Val Ile Arg Lys Trp Leu Ala Thr Ile Ser 85 90 95 Pro Asn Pro Val Ala Gln Leu Met Ile Ile Gly Trp Ala Phe Ala Phe 100 105 110 Met Ile Glu Gly Ala Ser Gly Phe Gly Thr Pro Ala Ala Ile Ala Ala 115 120 125 Pro Ile Leu Met Ser Leu Gly Phe Asn Pro Leu Lys Val Ala Ile Phe 130 135 140 Thr Leu Val Met Asn Ser Val Pro Val Ser Phe Gly Ala Val Gly Thr 145 150 155 160 Pro Thr Trp Phe Gly Phe Ala Pro Leu Asn Leu Ser Ala Glu Asp Ile 165 170 175 Leu Ala Ile Gly Arg Gln Thr Gly Val Met His Phe Phe Ala Gly Phe 180 185 190 Val Ile Pro Val Ile Gly Leu Gly Phe Ile Val Pro Trp Ser Glu Ile 195 200 205 Arg Lys Asn Leu Gly Phe Val Ala Ile Ala Val Phe Ser Cys Thr Ile 210 215 220 Pro Tyr Val Ala Leu Ala Met Val Asn Glu Glu Phe Pro Ser Leu Val 225 230 235 240 Ala Gly Ala Ile Gly Leu Met Val Ser Val Phe Ala Ala Asn Gln Gly 245 250 255 Trp Gly Leu Ser Lys Asp His Ala Lys Asp Pro Asn Ala Glu Lys Val 260 265 270 Pro Phe Ala Gln Val Ala Lys Ala Leu Ala Pro Leu Gly Met Leu Ile 275 280 285 Gly Met Leu Val Val Thr Arg Ile Lys Gln Leu Gly Ile Lys Gly Ile 290 295 300 Leu Thr Ser Lys Glu Glu Trp Phe Ser Phe Gln Leu Pro Phe Asp Leu 305 310 315 320 Ser Lys Ile Thr Val Ser Asp Ser Leu Thr Ile Thr Phe Gly Asn Ile 325 330 335 Phe Gly Gln Asp Val Ser Ala Ser Tyr Gln Thr Leu Tyr Val Pro Ala 340 345 350 Trp Ile Pro Phe Val Leu Thr Val Trp Ile Cys Ile Leu Leu Tyr Lys 355 360 365 Thr Lys Phe Lys Asp Ala Trp Thr Ile Tyr Ser Val Thr Phe Asn Gln 370 375 380 Thr Lys Lys Pro Leu Leu Ala Leu Met Gly Ala Leu Ile Met Val Gln 385 390 395 400 Leu Met Leu Val Gly Gly Asp Asn Ser Met Val Lys Ile Ile Gly Lys 405 410 415 Glu Phe Ala Ala Met Ala Gly Glu His Trp Val Tyr Phe Ser Pro Tyr 420 425 430 Leu Gly Ala Ile Gly Ala Phe Phe Ser Gly Ser Asn Thr Val Ser Asn 435 440 445 Leu Thr Phe Gly Pro Ile Gln Gln Gln Ile Ala Leu Asp Thr Gly Leu 450 455 460 Ser Val Thr Leu Ile Leu Ala Leu Gln Ser Val Gly Gly Ala Met Gly 465 470 475 480 Asn Met Val Cys Leu Asn Asn Ile Ile Ala Val Cys Thr Val Leu Asp 485 490 495 Val Lys Asn Ser Glu Gly Ala Ile Ile Lys Lys Thr Val Ile Pro Met 500 505 510 Ala Ile Tyr Gly Val Ile Ala Val Val Ala Ala Met Ile Phe Phe Leu 515 520 525 <210> 91 <211> 1686 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1686) <400> 91 atg tta caa tcc gaa aat tcg aaa aat tta atc tct tgt tca ata aag 48 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 gct tta cca atc atg att tct acc aac ggc atc acc atg cag ttc ggc 96 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 gcg aag ccg ctg ttt gaa aac gta tcc gtt aaa ttc ggc gaa ggc aac 144 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 cgc tac ggt ttg atc ggc gcg aac ggc tca ggc aaa tcc acc ttc atg 192 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 aaa atc ctc ggc ggc gat ttg gaa cag aca gcc ggc gaa gtg gcg att 240 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 gaa aac ggc gtg cgt ttg ggt aaa ttg cgc caa gac cag ttt gcc tac 288 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 gaa gat atg cgc gtg ctg gac gtg gta atg atg ggt cac acc gaa atg 336 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 tgg gcg gcg atg acc gaa cgt gat gcg att tac gcc aat ccc gaa gcc 384 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 acc gaa gac gac tac atg aaa gcc gca gaa ctg gaa gcc aag ttc gcc 432 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 gaa tac gac ggc tac acc gcc gaa gcg cgt gcc gcc gag ttg ttg agc 480 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 ggc gtg ggc att tcc gaa gat ttg cac aat gca acc atg gca gaa gtt 528 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 gcc ccg ggc ttc aaa ctg cgc gta ttg ctg gcg caa gcc ctg ttc tcc 576 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 aag ccg gat gta ttg ctc ttg gac gaa ccg acc aat aac ttg gac att 624 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 aat acc atc cgt tgg ttg gaa ggc gtg ttg aac cag tac gac tcc acg 672 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 atg att atc atc tcg cac gac cgc cac ttc ttg aac gaa gtc tgc acg 720 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 cat atg gca gat ttg gat tac aac acc atc acc atc tat ccg ggc aac 768 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 tac gac gac tat atg ctc gcc tcc gcc caa tcg cgc gaa cgc gcc ctg 816 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 aaa gac aat gcc aag gcg aag gaa aaa ttg cag gaa ttg caa gaa ttt 864 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 gtg gcg cgg ttc agt gcc aac aaa tcc aaa gcc cgt cag gca acc agc 912 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 cgt ctg aaa cag gca gac aaa atc aaa tcg gag atg gtc gag gtc aaa 960 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 ccc tct acc cgt caa aac ccg tat atc cgt ttt gaa gcc gat gaa aaa 1008 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 gcc aag ctg cac cgt cag gct gtg gaa gtt gaa aaa ctg gcg aaa cgc 1056 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 ttt gaa acc cag ttg ttt aaa aac ctg aac ttt atc ctt gaa gcg gga 1104 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 caa cgc ctc gcc atc atc ggc ccg aac ggc gcg ggc aaa tcc acc ctg 1152 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 ctg aaa ctc ttg gcc ggc gcg tac aac ccc gaa tat tca gac ggt ctg 1200 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 ctg ccg gac gaa ggc agc atc aaa tgg gcg gaa aaa gcc agc gtc ggc 1248 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 tac tat ccg caa gat cac gaa aac gac ttc gat gtc gat atg gat ttg 1296 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 agc gaa tgg atg cgc caa tgg ggg cag gac ggc gac gac gaa caa gtc 1344 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 atc cgc ggc act ttg ggg cgt ttg ctc ttc ggc agt aac gat gtc gtg 1392 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 aaa aaa gtg aag gtt ctc tcc ggt ggt gaa aaa ggc cgt atg ctt tac 1440 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 ggc aaa ctg ttg ctg ttg aaa ccc aat gtc tta gtc atg gat gaa ccg 1488 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 acc aac cac atg gac atg gaa agc atc gaa tcc ttg aac atg gcg ctg 1536 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 gaa aaa tac aac ggc acg ctg att ttc gtc tcc cac gac cgt cag ttc 1584 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 gtt tct tcc ctg gct acc caa atc att gaa ttg gac ggc aaa ggc gga 1632 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 tat gaa cac tac ttg ggc gat tac gaa agc tat ctc gag aaa aaa ggc 1680 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 gta gca 1686 Val Ala <210> 92 <211> 562 <212> PRT <213> Neisseria meningitidis <400> 92 Met Leu Gln Ser Glu Asn Ser Lys Asn Leu Ile Ser Cys Ser Ile Lys 1 5 10 15 Ala Leu Pro Ile Met Ile Ser Thr Asn Gly Ile Thr Met Gln Phe Gly 20 25 30 Ala Lys Pro Leu Phe Glu Asn Val Ser Val Lys Phe Gly Glu Gly Asn 35 40 45 Arg Tyr Gly Leu Ile Gly Ala Asn Gly Ser Gly Lys Ser Thr Phe Met 50 55 60 Lys Ile Leu Gly Gly Asp Leu Glu Gln Thr Ala Gly Glu Val Ala Ile 65 70 75 80 Glu Asn Gly Val Arg Leu Gly Lys Leu Arg Gln Asp Gln Phe Ala Tyr 85 90 95 Glu Asp Met Arg Val Leu Asp Val Val Met Met Gly His Thr Glu Met 100 105 110 Trp Ala Ala Met Thr Glu Arg Asp Ala Ile Tyr Ala Asn Pro Glu Ala 115 120 125 Thr Glu Asp Asp Tyr Met Lys Ala Ala Glu Leu Glu Ala Lys Phe Ala 130 135 140 Glu Tyr Asp Gly Tyr Thr Ala Glu Ala Arg Ala Ala Glu Leu Leu Ser 145 150 155 160 Gly Val Gly Ile Ser Glu Asp Leu His Asn Ala Thr Met Ala Glu Val 165 170 175 Ala Pro Gly Phe Lys Leu Arg Val Leu Leu Ala Gln Ala Leu Phe Ser 180 185 190 Lys Pro Asp Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Ile 195 200 205 Asn Thr Ile Arg Trp Leu Glu Gly Val Leu Asn Gln Tyr Asp Ser Thr 210 215 220 Met Ile Ile Ile Ser His Asp Arg His Phe Leu Asn Glu Val Cys Thr 225 230 235 240 His Met Ala Asp Leu Asp Tyr Asn Thr Ile Thr Ile Tyr Pro Gly Asn 245 250 255 Tyr Asp Asp Tyr Met Leu Ala Ser Ala Gln Ser Arg Glu Arg Ala Leu 260 265 270 Lys Asp Asn Ala Lys Ala Lys Glu Lys Leu Gln Glu Leu Gln Glu Phe 275 280 285 Val Ala Arg Phe Ser Ala Asn Lys Ser Lys Ala Arg Gln Ala Thr Ser 290 295 300 Arg Leu Lys Gln Ala Asp Lys Ile Lys Ser Glu Met Val Glu Val Lys 305 310 315 320 Pro Ser Thr Arg Gln Asn Pro Tyr Ile Arg Phe Glu Ala Asp Glu Lys 325 330 335 Ala Lys Leu His Arg Gln Ala Val Glu Val Glu Lys Leu Ala Lys Arg 340 345 350 Phe Glu Thr Gln Leu Phe Lys Asn Leu Asn Phe Ile Leu Glu Ala Gly 355 360 365 Gln Arg Leu Ala Ile Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu 370 375 380 Leu Lys Leu Leu Ala Gly Ala Tyr Asn Pro Glu Tyr Ser Asp Gly Leu 385 390 395 400 Leu Pro Asp Glu Gly Ser Ile Lys Trp Ala Glu Lys Ala Ser Val Gly 405 410 415 Tyr Tyr Pro Gln Asp His Glu Asn Asp Phe Asp Val Asp Met Asp Leu 420 425 430 Ser Glu Trp Met Arg Gln Trp Gly Gln Asp Gly Asp Asp Glu Gln Val 435 440 445 Ile Arg Gly Thr Leu Gly Arg Leu Leu Phe Gly Ser Asn Asp Val Val 450 455 460 Lys Lys Val Lys Val Leu Ser Gly Gly Glu Lys Gly Arg Met Leu Tyr 465 470 475 480 Gly Lys Leu Leu Leu Leu Lys Pro Asn Val Leu Val Met Asp Glu Pro 485 490 495 Thr Asn His Met Asp Met Glu Ser Ile Glu Ser Leu Asn Met Ala Leu 500 505 510 Glu Lys Tyr Asn Gly Thr Leu Ile Phe Val Ser His Asp Arg Gln Phe 515 520 525 Val Ser Ser Leu Ala Thr Gln Ile Ile Glu Leu Asp Gly Lys Gly Gly 530 535 540 Tyr Glu His Tyr Leu Gly Asp Tyr Glu Ser Tyr Leu Glu Lys Lys Gly 545 550 555 560 Val Ala <210> 93 <211> 1126 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1125) <400> 93 atg aac acc tcg caa cgc aac cgc ctc gtc agc cgc tgg ctc aac tcc 48 Met Asn Thr Ser Gln Arg Asn Arg Leu Val Ser Arg Trp Leu Asn Ser 1 5 10 15 tac gaa cgc tac cgc tac cgc cgc ctc atc cac gcc gtc cgg ctc ggc 96 Tyr Glu Arg Tyr Arg Tyr Arg Arg Leu Ile His Ala Val Arg Leu Gly 20 25 30 ggg gcc gtc ctg ttc gcc acc gcc tcc gcc cgg ctg ctc cac ctc caa 144 Gly Ala Val Leu Phe Ala Thr Ala Ser Ala Arg Leu Leu His Leu Gln 35 40 45 cac ggc gag tgg ata ggg atg acc gtc ttc gtc gtc ctc ggc atg ctc 192 His Gly Glu Trp Ile Gly Met Thr Val Phe Val Val Leu Gly Met Leu 50 55 60 cag ttt caa ggg gcg att tac tcc aag gcg gtg gaa cgt atg ctc ggc 240 Gln Phe Gln Gly Ala Ile Tyr Ser Lys Ala Val Glu Arg Met Leu Gly 65 70 75 80 acg gtc atc ggg ctg ggc gcg ggt ttg ggc gtt tta tgg ctg aac cag 288 Thr Val Ile Gly Leu Gly Ala Gly Leu Gly Val Leu Trp Leu Asn Gln 85 90 95 cat tat ttc cac ggc aac ctc ctc ttc tac ctc acc gtc ggc acg gca 336 His Tyr Phe His Gly Asn Leu Leu Phe Tyr Leu Thr Val Gly Thr Ala 100 105 110 agc gca ctg gcc ggc tgg gcg gcg gtc ggc aaa aac ggc tac gtc cct 384 Ser Ala Leu Ala Gly Trp Ala Ala Val Gly Lys Asn Gly Tyr Val Pro 115 120 125 atg ctg gcg ggg ctg acg atg tgc atg ctc atc ggc gac aac ggc agc 432 Met Leu Ala Gly Leu Thr Met Cys Met Leu Ile Gly Asp Asn Gly Ser 130 135 140 gaa tgg ttc gac agc ggc ctg atg cgc gcg atg aac gtc ctc atc ggc 480 Glu Trp Phe Asp Ser Gly Leu Met Arg Ala Met Asn Val Leu Ile Gly 145 150 155 160 gcg gcc atc gcc atc gcc gcc gcc aaa ctg ctg ccg ctg aaa tcc aca 528 Ala Ala Ile Ala Ile Ala Ala Ala Lys Leu Leu Pro Leu Lys Ser Thr 165 170 175 ctg atg tgg cgt ttc atg ctt gcc gac aac ctg acc gac tgc agc aaa 576 Leu Met Trp Arg Phe Met Leu Ala Asp Asn Leu Thr Asp Cys Ser Lys 180 185 190 atg att gcc gaa atc agc aac ggc agg cgc atg acc cgc gaa cgc ctc 624 Met Ile Ala Glu Ile Ser Asn Gly Arg Arg Met Thr Arg Glu Arg Leu 195 200 205 gaa gag aac atg gcg aaa atg cgc caa atc aac gca cgc atg gtc aaa 672 Glu Glu Asn Met Ala Lys Met Arg Gln Ile Asn Ala Arg Met Val Lys 210 215 220 agc cgc agc cac ctc gcc gcc aca tcg ggc gaa agc cgc atc agc ccc 720 Ser Arg Ser His Leu Ala Ala Thr Ser Gly Glu Ser Arg Ile Ser Pro 225 230 235 240 gcc atg atg gaa gcc atg cag cac gcc cac cgt aaa att gtc aac acc 768 Ala Met Met Glu Ala Met Gln His Ala His Arg Lys Ile Val Asn Thr 245 250 255 acc gag ctg ctc ctg acc acc gcc gcc aag ctg caa tct ccc aaa ctc 816 Thr Glu Leu Leu Leu Thr Thr Ala Ala Lys Leu Gln Ser Pro Lys Leu 260 265 270 aac ggc agc gaa atc cgg ctg ctt gac cgc cac ttc aca ctg ctc caa 864 Asn Gly Ser Glu Ile Arg Leu Leu Asp Arg His Phe Thr Leu Leu Gln 275 280 285 acc gac ctg caa caa acc gtc gcc ctt atc aac ggc aga cac gcc cgc 912 Thr Asp Leu Gln Gln Thr Val Ala Leu Ile Asn Gly Arg His Ala Arg 290 295 300 cgc atc cgc atc gac acc gcc atc aac ccc gaa ctg gaa gcc ctc gcc 960 Arg Ile Arg Ile Asp Thr Ala Ile Asn Pro Glu Leu Glu Ala Leu Ala 305 310 315 320 gaa cac ctc cac tac caa tgg cag ggc ttc ctc tgg ctc agc acc aat 1008 Glu His Leu His Tyr Gln Trp Gln Gly Phe Leu Trp Leu Ser Thr Asn 325 330 335 atg cgt cag gaa att tcc gcc ctc gtc atc ctg ctg caa cgc acc cgc 1056 Met Arg Gln Glu Ile Ser Ala Leu Val Ile Leu Leu Gln Arg Thr Arg 340 345 350 cgc aaa tgg ctg gat gcc cac gaa cgc caa cac ctg cgc caa agc ctg 1104 Arg Lys Trp Leu Asp Ala His Glu Arg Gln His Leu Arg Gln Ser Leu 355 360 365 ctt gaa aca cgg gaa cac agt t 1126 Leu Glu Thr Arg Glu His Ser 370 375 <210> 94 <211> 375 <212> PRT <213> Neisseria meningitidis <400> 94 Met Asn Thr Ser Gln Arg Asn Arg Leu Val Ser Arg Trp Leu Asn Ser 1 5 10 15 Tyr Glu Arg Tyr Arg Tyr Arg Arg Leu Ile His Ala Val Arg Leu Gly 20 25 30 Gly Ala Val Leu Phe Ala Thr Ala Ser Ala Arg Leu Leu His Leu Gln 35 40 45 His Gly Glu Trp Ile Gly Met Thr Val Phe Val Val Leu Gly Met Leu 50 55 60 Gln Phe Gln Gly Ala Ile Tyr Ser Lys Ala Val Glu Arg Met Leu Gly 65 70 75 80 Thr Val Ile Gly Leu Gly Ala Gly Leu Gly Val Leu Trp Leu Asn Gln 85 90 95 His Tyr Phe His Gly Asn Leu Leu Phe Tyr Leu Thr Val Gly Thr Ala 100 105 110 Ser Ala Leu Ala Gly Trp Ala Ala Val Gly Lys Asn Gly Tyr Val Pro 115 120 125 Met Leu Ala Gly Leu Thr Met Cys Met Leu Ile Gly Asp Asn Gly Ser 130 135 140 Glu Trp Phe Asp Ser Gly Leu Met Arg Ala Met Asn Val Leu Ile Gly 145 150 155 160 Ala Ala Ile Ala Ile Ala Ala Ala Lys Leu Leu Pro Leu Lys Ser Thr 165 170 175 Leu Met Trp Arg Phe Met Leu Ala Asp Asn Leu Thr Asp Cys Ser Lys 180 185 190 Met Ile Ala Glu Ile Ser Asn Gly Arg Arg Met Thr Arg Glu Arg Leu 195 200 205 Glu Glu Asn Met Ala Lys Met Arg Gln Ile Asn Ala Arg Met Val Lys 210 215 220 Ser Arg Ser His Leu Ala Ala Thr Ser Gly Glu Ser Arg Ile Ser Pro 225 230 235 240 Ala Met Met Glu Ala Met Gln His Ala His Arg Lys Ile Val Asn Thr 245 250 255 Thr Glu Leu Leu Leu Thr Thr Ala Ala Lys Leu Gln Ser Pro Lys Leu 260 265 270 Asn Gly Ser Glu Ile Arg Leu Leu Asp Arg His Phe Thr Leu Leu Gln 275 280 285 Thr Asp Leu Gln Gln Thr Val Ala Leu Ile Asn Gly Arg His Ala Arg 290 295 300 Arg Ile Arg Ile Asp Thr Ala Ile Asn Pro Glu Leu Glu Ala Leu Ala 305 310 315 320 Glu His Leu His Tyr Gln Trp Gln Gly Phe Leu Trp Leu Ser Thr Asn 325 330 335 Met Arg Gln Glu Ile Ser Ala Leu Val Ile Leu Leu Gln Arg Thr Arg 340 345 350 Arg Lys Trp Leu Asp Ala His Glu Arg Gln His Leu Arg Gln Ser Leu 355 360 365 Leu Glu Thr Arg Glu His Ser 370 375 <210> 95 <211> 1725 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1725) <400> 95 atg cag cta tca ggc gcg caa atc ata gtg cag agt ctc aaa gcc gaa 48 Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu 1 5 10 15 ggt gtc gag tac gtt ttc ggt tat ccc ggc ggt gcg gtt atc gaa atc 96 Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile 20 25 30 tac gat gcc ctt ttc caa ctc aat aaa ttc aag cac att ctg acc cgt 144 Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg 35 40 45 cac gag cag gcg gca gta cac gcg gca gat gcg tat gcg cgc gtc agc 192 His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser 50 55 60 ggt aag gtg ggc gtg gca ttg gtt aca tcc ggc ccg ggc gtt acc aat 240 Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn 65 70 75 80 gca ctg acc ggt att gct act gcc tat acg gat tcg att ccg atg gtg 288 Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val 85 90 95 gtc atc agc ggg cag gta ggc aat tcc ctg att ggt acg gat gcg ttc 336 Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe 100 105 110 caa gaa gtt gat acg gtg ggt att acc cgt ccg tgc gtc aaa cac aat 384 Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn 115 120 125 ttc ctg gtt acg gac atc aat gag ttg gcg gaa acc att aaa aag gcg 432 Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala 130 135 140 ttc caa att gcc gca agc ggc cga ccg ggg ccc gtg gtg gtt gat gtc 480 Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val 145 150 155 160 ccg aaa gat gtt acg cag gcg atg gcg aaa ttc agc tat cct cag gaa 528 Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu 165 170 175 gac att ttt atc cgt tcg tat caa ccg gtt gtt caa ggg cat atc ggt 576 Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly 180 185 190 cag att aaa aag gcc gtg cag atg ttg gca tct gcc aaa cgt ccg gtc 624 Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val 195 200 205 gtc tat ttt ggc ggc ggc gtg gtg ttg ggt aat gct tct gaa gag ctg 672 Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu 210 215 220 acc cga ttt gtc cga atg acg ggt gct ccg tgc acg ggt acg ctg atg 720 Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met 225 230 235 240 ggc ttg ggc gct tat cct tcc ggc gac cgc caa ttc ctc ggt atg ctc 768 Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu 245 250 255 ggt atg cac ggt act tac gag gca aac ctt gcc atg cag aat gcg gat 816 Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp 260 265 270 gtc gtt ctt gcc gta ggt gcg cgt ttt gac gac cgt gtg gtt tcc gta 864 Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val 275 280 285 ccg tcc aaa ttt ttc gag aag gcg aag aag gtt atc cat atc gat gtc 912 Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val 290 295 300 gat cct tcc agc atc gcc aaa cgc gtg aag gcg gac att ccg att gtc 960 Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val 305 310 315 320 ggc gac gtg aaa aac gtt ttg tcc gag atg gtt gcg ctg tgg caa aaa 1008 Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys 325 330 335 caa gag tcc gtg ccg tct gaa gat gct ttg ggc aaa tgg tgg aaa acc 1056 Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr 340 345 350 ata gag gaa tgg cgt tcc cgc gat tgc ttg tgg ttt gac aac ggc agc 1104 Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser 355 360 365 gaa att atc aag cca caa tat gtg att cag aag ctt gcc gag att acc 1152 Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr 370 375 380 ggc aat tcg gca atc atc aca tcg gat gta ggg cag cat caa atg ttt 1200 Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe 385 390 395 400 gcg gct caa tat tat ccc ttc gaa cgt ccg cgc caa tgg ctc aac tcc 1248 Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser 405 410 415 ggc ggt ttg ggt acg atg ggc gtt ggt ctg cct tat gcg att ggt gca 1296 Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala 420 425 430 aaa ctt gcc gcc ccg gat caa gac gta ttc tgt att acc ggc gac ggc 1344 Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly 435 440 445 tcg atc cag atg aac atc caa gag ctg tcc acc tgt ttc caa tat cgg 1392 Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg 450 455 460 att ccg gtt aac gtc att acg ctg aac aac ggt tat ctc ggt atg gta 1440 Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val 465 470 475 480 cgc cag tgg cag gaa ata tat tac ggc gga cga gag tcg gaa acc tat 1488 Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr 485 490 495 ttc gat tct ttg ccc gat ttc gtc aaa ctt gcc gag gca tac ggc cat 1536 Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His 500 505 510 atc ggt atc cgc gtg gac aag aag tct gat gtg gaa ggt gcg ttg ttg 1584 Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu 515 520 525 gaa gca ttg aac caa aaa gac agg ctg gtg ttt atc gac ttc ctg acc 1632 Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr 530 535 540 gac cag aaa cag aat gtg atg ccc atg gtc ggc aac ggc aaa ggt ttg 1680 Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu 545 550 555 560 gac gaa atg gta ctt ccg ccg cat atg cgt gcg gac gga aag gcg 1725 Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala 565 570 575 <210> 96 <211> 575 <212> PRT <213> Neisseria meningitidis <400> 96 Met Gln Leu Ser Gly Ala Gln Ile Ile Val Gln Ser Leu Lys Ala Glu 1 5 10 15 Gly Val Glu Tyr Val Phe Gly Tyr Pro Gly Gly Ala Val Ile Glu Ile 20 25 30 Tyr Asp Ala Leu Phe Gln Leu Asn Lys Phe Lys His Ile Leu Thr Arg 35 40 45 His Glu Gln Ala Ala Val His Ala Ala Asp Ala Tyr Ala Arg Val Ser 50 55 60 Gly Lys Val Gly Val Ala Leu Val Thr Ser Gly Pro Gly Val Thr Asn 65 70 75 80 Ala Leu Thr Gly Ile Ala Thr Ala Tyr Thr Asp Ser Ile Pro Met Val 85 90 95 Val Ile Ser Gly Gln Val Gly Asn Ser Leu Ile Gly Thr Asp Ala Phe 100 105 110 Gln Glu Val Asp Thr Val Gly Ile Thr Arg Pro Cys Val Lys His Asn 115 120 125 Phe Leu Val Thr Asp Ile Asn Glu Leu Ala Glu Thr Ile Lys Lys Ala 130 135 140 Phe Gln Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp Val 145 150 155 160 Pro Lys Asp Val Thr Gln Ala Met Ala Lys Phe Ser Tyr Pro Gln Glu 165 170 175 Asp Ile Phe Ile Arg Ser Tyr Gln Pro Val Val Gln Gly His Ile Gly 180 185 190 Gln Ile Lys Lys Ala Val Gln Met Leu Ala Ser Ala Lys Arg Pro Val 195 200 205 Val Tyr Phe Gly Gly Gly Val Val Leu Gly Asn Ala Ser Glu Glu Leu 210 215 220 Thr Arg Phe Val Arg Met Thr Gly Ala Pro Cys Thr Gly Thr Leu Met 225 230 235 240 Gly Leu Gly Ala Tyr Pro Ser Gly Asp Arg Gln Phe Leu Gly Met Leu 245 250 255 Gly Met His Gly Thr Tyr Glu Ala Asn Leu Ala Met Gln Asn Ala Asp 260 265 270 Val Val Leu Ala Val Gly Ala Arg Phe Asp Asp Arg Val Val Ser Val 275 280 285 Pro Ser Lys Phe Phe Glu Lys Ala Lys Lys Val Ile His Ile Asp Val 290 295 300 Asp Pro Ser Ser Ile Ala Lys Arg Val Lys Ala Asp Ile Pro Ile Val 305 310 315 320 Gly Asp Val Lys Asn Val Leu Ser Glu Met Val Ala Leu Trp Gln Lys 325 330 335 Gln Glu Ser Val Pro Ser Glu Asp Ala Leu Gly Lys Trp Trp Lys Thr 340 345 350 Ile Glu Glu Trp Arg Ser Arg Asp Cys Leu Trp Phe Asp Asn Gly Ser 355 360 365 Glu Ile Ile Lys Pro Gln Tyr Val Ile Gln Lys Leu Ala Glu Ile Thr 370 375 380 Gly Asn Ser Ala Ile Ile Thr Ser Asp Val Gly Gln His Gln Met Phe 385 390 395 400 Ala Ala Gln Tyr Tyr Pro Phe Glu Arg Pro Arg Gln Trp Leu Asn Ser 405 410 415 Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala Ile Gly Ala 420 425 430 Lys Leu Ala Ala Pro Asp Gln Asp Val Phe Cys Ile Thr Gly Asp Gly 435 440 445 Ser Ile Gln Met Asn Ile Gln Glu Leu Ser Thr Cys Phe Gln Tyr Arg 450 455 460 Ile Pro Val Asn Val Ile Thr Leu Asn Asn Gly Tyr Leu Gly Met Val 465 470 475 480 Arg Gln Trp Gln Glu Ile Tyr Tyr Gly Gly Arg Glu Ser Glu Thr Tyr 485 490 495 Phe Asp Ser Leu Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly His 500 505 510 Ile Gly Ile Arg Val Asp Lys Lys Ser Asp Val Glu Gly Ala Leu Leu 515 520 525 Glu Ala Leu Asn Gln Lys Asp Arg Leu Val Phe Ile Asp Phe Leu Thr 530 535 540 Asp Gln Lys Gln Asn Val Met Pro Met Val Gly Asn Gly Lys Gly Leu 545 550 555 560 Asp Glu Met Val Leu Pro Pro His Met Arg Ala Asp Gly Lys Ala 565 570 575 <210> 97 <211> 570 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(570) <400> 97 atg gac aat cac gcc gaa gca cac tgg caa aac ggc tgg ctt caa agc 48 Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser 1 5 10 15 ata cgc cat acc ccg tcg ccc aat ttc agc ccg agg gaa acg ggg gaa 96 Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu 20 25 30 acg gtt tcc ctg atc gtg ttg cac aac att tca ctg ccg ccg ttc gaa 144 Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu 35 40 45 tac ggc acg gat gct gtg gaa aag ctg ttt gcc aac cgg ctc gac ccc 192 Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro 50 55 60 aac gga cat ccg ttc ttc agc ctg ata cac act ttg cgc gta tcc agc 240 Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser 65 70 75 80 cat ttc tta atc aaa cgc gac ggc aaa acg gtg cag ttc gta tca tgc 288 His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys 85 90 95 ggc gat atg gcg tac cac gcg ggc gta tcc tcg ttt cgc gga cgg gaa 336 Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu 100 105 110 aaa tgc aac gca ttt tcc atc ggc atc gaa ttg gaa ggc tgc gat ttc 384 Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe 115 120 125 gaa ccc ttt acc gaa gcg caa tac cgt tcg ctc gaa aca ttg ttg gaa 432 Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu 130 135 140 gca ctc tgc cgc cgc tac ccc gtt acc gca gta acc gga cat cag gac 480 Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp 145 150 155 160 atc gcg ccc ggc cgc aaa acc gac ccc ggc cac ttt ttc gac tgg cgg 528 Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg 165 170 175 cgg ata cgg gag aaa ggg ttt ccc gta gac aga aat gcc gtc 570 Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val 180 185 190 <210> 98 <211> 190 <212> PRT <213> Neisseria meningitidis <400> 98 Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser 1 5 10 15 Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu 20 25 30 Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu 35 40 45 Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro 50 55 60 Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser 65 70 75 80 His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys 85 90 95 Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu 100 105 110 Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe 115 120 125 Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu 130 135 140 Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp 145 150 155 160 Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg 165 170 175 Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val 180 185 190 <210> 99 <211> 1515 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1515) <400> 99 atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt 48 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag 96 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg 144 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt 192 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc 240 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc 288 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg 336 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg 384 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg 432 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat 480 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat 528 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt 576 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg 624 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc 672 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa 720 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc 768 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg 816 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg 864 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc 912 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat 960 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca 1008 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc 1056 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg 1104 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc 1152 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc 1200 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc 1248 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc 1296 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca 1344 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac 1392 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc 1440 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag 1488 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 gtg ttt gtg tcg gcg gat tgg cgg ttt 1515 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 100 <211> 505 <212> PRT <213> Neisseria meningitidis <400> 100 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 101 <211> 1476 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1476) <400> 101 atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag 48 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg 96 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg 144 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg 192 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc 240 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat 288 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa 336 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa 384 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg 432 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg 480 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa 528 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att 576 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc 624 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc 672 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc 720 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa 768 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa 816 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcg ttg gaa ggt 864 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc 912 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac 960 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg 1008 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 gcg ttg aac gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa 1056 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg 1104 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg 1152 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc 1200 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc 1248 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg 1296 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga 1344 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa 1392 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg 1440 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 gct aag att gat gag att tgg gag gaa ttg ggg ttg 1476 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 102 <211> 492 <212> PRT <213> Neisseria meningitidis <400> 102 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 103 <211> 1089 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1089) <400> 103 atg agt ttg aaa tgc ggc atc gtc ggt ttg ccc aac gtc ggc aaa tcc 48 Met Ser Leu Lys Cys Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser 1 5 10 15 acc ctt ttt aac gcg ctg acc caa tcg ggt atc gaa gcg gca aac tat 96 Thr Leu Phe Asn Ala Leu Thr Gln Ser Gly Ile Glu Ala Ala Asn Tyr 20 25 30 cct ttc tgt acc atc gaa ccc aac gtc ggc atc gtc gaa gtc ccc gat 144 Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Glu Val Pro Asp 35 40 45 ccg cgt atg gcc gaa ttg gca aaa atc gtc aat ccg caa aaa atg cag 192 Pro Arg Met Ala Glu Leu Ala Lys Ile Val Asn Pro Gln Lys Met Gln 50 55 60 cct gcc atc gtc gaa ttt gtc gat att gcc ggt ttg gtt gca ggc gcg 240 Pro Ala Ile Val Glu Phe Val Asp Ile Ala Gly Leu Val Ala Gly Ala 65 70 75 80 agc aaa ggc gag ggc ttg ggc aac cag ttc ctt gcc aac atc cgc gaa 288 Ser Lys Gly Glu Gly Leu Gly Asn Gln Phe Leu Ala Asn Ile Arg Glu 85 90 95 acc gat gcg att gtg aat gtc gtg cgc tgc ttt gac gac gac aac atc 336 Thr Asp Ala Ile Val Asn Val Val Arg Cys Phe Asp Asp Asp Asn Ile 100 105 110 gtc cac gtt gca ggc cgc gtc gat ccg att gcc gac att gaa acc atc 384 Val His Val Ala Gly Arg Val Asp Pro Ile Ala Asp Ile Glu Thr Ile 115 120 125 ggc aca gag ttg gca ctt gcc gac ctg gca agt gtc gaa aaa gcc atc 432 Gly Thr Glu Leu Ala Leu Ala Asp Leu Ala Ser Val Glu Lys Ala Ile 130 135 140 gtc cgc gaa gaa aaa cgc gcc cgc tca ggc gac aaa gac gcg caa aag 480 Val Arg Glu Glu Lys Arg Ala Arg Ser Gly Asp Lys Asp Ala Gln Lys 145 150 155 160 ctg gtc gat ttg tgc aaa aaa ctg ctg ccg cat ctg gac gaa ggc aaa 528 Leu Val Asp Leu Cys Lys Lys Leu Leu Pro His Leu Asp Glu Gly Lys 165 170 175 ccc gtg cgt tcc ttc ggt ttg gac gcg gaa gaa cgc gcg atg ctc aaa 576 Pro Val Arg Ser Phe Gly Leu Asp Ala Glu Glu Arg Ala Met Leu Lys 180 185 190 ccg ctg ttc ctg ctg acc gcc aaa ccg gcg atg tat gtg ggc aac gtc 624 Pro Leu Phe Leu Leu Thr Ala Lys Pro Ala Met Tyr Val Gly Asn Val 195 200 205 gcc gaa gac ggt ttt gaa aac aat ccg cac ctc gac cgc ctg aaa gaa 672 Ala Glu Asp Gly Phe Glu Asn Asn Pro His Leu Asp Arg Leu Lys Glu 210 215 220 ttg gcg gca aaa gaa aac gcc ccc gtc gtc gcc gtt tgc gcc gcg atg 720 Leu Ala Ala Lys Glu Asn Ala Pro Val Val Ala Val Cys Ala Ala Met 225 230 235 240 gag agc gaa att gcc gaa ttg gaa gac gac gaa aaa gcc gag ttc ctc 768 Glu Ser Glu Ile Ala Glu Leu Glu Asp Asp Glu Lys Ala Glu Phe Leu 245 250 255 gcc gaa atg ggc ttg gaa gaa ccg ggc ctg aac cgc ctg att cgt gcc 816 Ala Glu Met Gly Leu Glu Glu Pro Gly Leu Asn Arg Leu Ile Arg Ala 260 265 270 ggt tac gac ctc ttg ggg ctg caa acc tat ttc acc gcc ggt gtg aaa 864 Gly Tyr Asp Leu Leu Gly Leu Gln Thr Tyr Phe Thr Ala Gly Val Lys 275 280 285 gaa gtc cgc gcg tgg acg ata cac aaa ggc gat acc gcc ccg caa gcc 912 Glu Val Arg Ala Trp Thr Ile His Lys Gly Asp Thr Ala Pro Gln Ala 290 295 300 gcc ggc gtg att cac acc gac ttt gag cgc ggc ttc atc cgc gcc caa 960 Ala Gly Val Ile His Thr Asp Phe Glu Arg Gly Phe Ile Arg Ala Gln 305 310 315 320 gtc att tct tac gac gac ttt gtc tcg ctc ggc ggc gaa gcc aaa gcc 1008 Val Ile Ser Tyr Asp Asp Phe Val Ser Leu Gly Gly Glu Ala Lys Ala 325 330 335 aaa gaa gcc ggc aaa atg cgt gtg gaa ggt aag gaa tac gtc gtg cag 1056 Lys Glu Ala Gly Lys Met Arg Val Glu Gly Lys Glu Tyr Val Val Gln 340 345 350 gac ggc gat gta atg cac ttt ttg ttt aac gtg 1089 Asp Gly Asp Val Met His Phe Leu Phe Asn Val 355 360 <210> 104 <211> 363 <212> PRT <213> Neisseria meningitidis <400> 104 Met Ser Leu Lys Cys Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser 1 5 10 15 Thr Leu Phe Asn Ala Leu Thr Gln Ser Gly Ile Glu Ala Ala Asn Tyr 20 25 30 Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Glu Val Pro Asp 35 40 45 Pro Arg Met Ala Glu Leu Ala Lys Ile Val Asn Pro Gln Lys Met Gln 50 55 60 Pro Ala Ile Val Glu Phe Val Asp Ile Ala Gly Leu Val Ala Gly Ala 65 70 75 80 Ser Lys Gly Glu Gly Leu Gly Asn Gln Phe Leu Ala Asn Ile Arg Glu 85 90 95 Thr Asp Ala Ile Val Asn Val Val Arg Cys Phe Asp Asp Asp Asn Ile 100 105 110 Val His Val Ala Gly Arg Val Asp Pro Ile Ala Asp Ile Glu Thr Ile 115 120 125 Gly Thr Glu Leu Ala Leu Ala Asp Leu Ala Ser Val Glu Lys Ala Ile 130 135 140 Val Arg Glu Glu Lys Arg Ala Arg Ser Gly Asp Lys Asp Ala Gln Lys 145 150 155 160 Leu Val Asp Leu Cys Lys Lys Leu Leu Pro His Leu Asp Glu Gly Lys 165 170 175 Pro Val Arg Ser Phe Gly Leu Asp Ala Glu Glu Arg Ala Met Leu Lys 180 185 190 Pro Leu Phe Leu Leu Thr Ala Lys Pro Ala Met Tyr Val Gly Asn Val 195 200 205 Ala Glu Asp Gly Phe Glu Asn Asn Pro His Leu Asp Arg Leu Lys Glu 210 215 220 Leu Ala Ala Lys Glu Asn Ala Pro Val Val Ala Val Cys Ala Ala Met 225 230 235 240 Glu Ser Glu Ile Ala Glu Leu Glu Asp Asp Glu Lys Ala Glu Phe Leu 245 250 255 Ala Glu Met Gly Leu Glu Glu Pro Gly Leu Asn Arg Leu Ile Arg Ala 260 265 270 Gly Tyr Asp Leu Leu Gly Leu Gln Thr Tyr Phe Thr Ala Gly Val Lys 275 280 285 Glu Val Arg Ala Trp Thr Ile His Lys Gly Asp Thr Ala Pro Gln Ala 290 295 300 Ala Gly Val Ile His Thr Asp Phe Glu Arg Gly Phe Ile Arg Ala Gln 305 310 315 320 Val Ile Ser Tyr Asp Asp Phe Val Ser Leu Gly Gly Glu Ala Lys Ala 325 330 335 Lys Glu Ala Gly Lys Met Arg Val Glu Gly Lys Glu Tyr Val Val Gln 340 345 350 Asp Gly Asp Val Met His Phe Leu Phe Asn Val 355 360 <210> 105 <211> 1177 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1176) <400> 105 atg gca aaa atg atg aaa tgg gcg gct gtt gcg gcg gtc gcg gcg gca 48 Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala 1 5 10 15 gcg gtt tgg ggc gga tgg tct tat ctg aag ccc gag ccg cag gct gct 96 Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala 20 25 30 tat att acg gaa acg gtc agg cgc ggc gac atc agc cgg acg gtt tct 144 Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser 35 40 45 gca aca ggg gag att tcg ccg tcc aac ctg gta tcg gtc ggc gcg cag 192 Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln 50 55 60 gca tcg ggg cag att aag aaa ctt tat gtc aaa ctc ggg caa cag gtt 240 Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val 65 70 75 80 aaa aag ggc gat ttg att gcg gaa atc aat tcg acc tcg cag acc aat 288 Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn 85 90 95 acg ctc aat acg gaa aaa tcc aaa ttg gaa acg tat cag gcg aag ctg 336 Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu 100 105 110 gtg tcg gca cag att gca ttg ggc agc gcg gag aag aaa tat aag cgt 384 Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg 115 120 125 cag gcg gcg ttg tgg aag gat gat gcg acc gct aaa gaa gat ttg gaa 432 Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu 130 135 140 agc gca cag gat gcg ctt gcc gcc gcc aaa gcc aat gtt gcc gag ctg 480 Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu 145 150 155 160 aag gct cta atc aga cag agc aaa att tcc atc aat acc gcc gag tcg 528 Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser 165 170 175 gaa ttg ggc tac acg cgc att acc gca acg atg gac ggc acg gtg gtg 576 Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val 180 185 190 gcg att ctc gtg gaa gag ggg cag act gtg aac gcg gcg cag tct acg 624 Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr 195 200 205 ccg acg att gtc caa ttg gcg aat ctg gat atg atg ttg aac aaa atg 672 Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met 210 215 220 cag att gcc gag ggc gat att acc aag gtg aag gcg ggg cag gat att 720 Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile 225 230 235 240 tcg ttt acg att ttg tcc gaa ccg gat acg ccg att aag gcg aag ctc 768 Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu 245 250 255 gac agc gtc gac ccc ggg ctg acc acg atg tcg tcg ggc ggc tac aac 816 Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn 260 265 270 agc agt acg gat acg gct tcc aat gcg gtc tac tat tat gcc cgt tcg 864 Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser 275 280 285 ttt gtg ccg aat ccg gac ggc aaa ctc gcc acg ggg atg acg acg cag 912 Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln 290 295 300 aat acg gtt gaa atc gac ggt gtg aaa aat gtg ctg att att ccg tcg 960 Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser 305 310 315 320 ctg acc gtg aaa aat cgc ggc ggc agg gcg ttt gtg cgc gtg ttg ggt 1008 Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly 325 330 335 gca gac ggc aag gcg gcg gaa cgc gaa atc cgg acc ggt atg aga gac 1056 Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp 340 345 350 agt atg aat acc gaa gta aaa agc ggg ttg aaa gag ggg gac aaa gtg 1104 Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val 355 360 365 gtc atc tcc gaa ata acc gcc gcc gag cag cag gaa agc ggc gaa cgc 1152 Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg 370 375 380 gcc cta ggc ggc ccg ccg cgc cga t 1177 Ala Leu Gly Gly Pro Pro Arg Arg 385 390 <210> 106 <211> 392 <212> PRT <213> Neisseria meningitidis <400> 106 Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala 1 5 10 15 Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala 20 25 30 Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser 35 40 45 Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln 50 55 60 Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val 65 70 75 80 Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn 85 90 95 Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu 100 105 110 Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg 115 120 125 Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu 130 135 140 Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu 145 150 155 160 Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser 165 170 175 Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val 180 185 190 Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr 195 200 205 Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met 210 215 220 Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile 225 230 235 240 Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu 245 250 255 Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn 260 265 270 Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser 275 280 285 Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln 290 295 300 Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser 305 310 315 320 Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly 325 330 335 Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp 340 345 350 Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val 355 360 365 Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg 370 375 380 Ala Leu Gly Gly Pro Pro Arg Arg 385 390 <210> 107 <211> 1185 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1185) <400> 107 atg aca gag gac gaa cgt ttc gcg tgg ctg caa ttg gcg ttt acg ccc 48 Met Thr Glu Asp Glu Arg Phe Ala Trp Leu Gln Leu Ala Phe Thr Pro 1 5 10 15 tat atc ggc gcg gaa agt ttc ctg ctg ctg atg cgc cgt ttc ggc agc 96 Tyr Ile Gly Ala Glu Ser Phe Leu Leu Leu Met Arg Arg Phe Gly Ser 20 25 30 gcg caa aat gcc ctg tcc gca ccg gcg gaa cag gtg gcg gca ctg ata 144 Ala Gln Asn Ala Leu Ser Ala Pro Ala Glu Gln Val Ala Ala Leu Ile 35 40 45 cgg cac aaa cag gcg ctt gag gct tgg cgc aat gcg gaa aaa cgc gct 192 Arg His Lys Gln Ala Leu Glu Ala Trp Arg Asn Ala Glu Lys Arg Ala 50 55 60 ctg gcg cgg cag gcg gca gaa gcg gcg ttg gaa tgg gaa atg cgg gac 240 Leu Ala Arg Gln Ala Ala Glu Ala Ala Leu Glu Trp Glu Met Arg Asp 65 70 75 80 gga tgc cgc ctg atg ctg ctt cag gat gaa gat ttc ccc gaa atg ctg 288 Gly Cys Arg Leu Met Leu Leu Gln Asp Glu Asp Phe Pro Glu Met Leu 85 90 95 acg cag ggg ctg acc gcg ccg ccg gtt ttg ttt ttg cgc ggc aac gtg 336 Thr Gln Gly Leu Thr Ala Pro Pro Val Leu Phe Leu Arg Gly Asn Val 100 105 110 cgg ctg ctg cac aag cct tcc gcc gcc atc gtc ggc agc cgc cat gcc 384 Arg Leu Leu His Lys Pro Ser Ala Ala Ile Val Gly Ser Arg His Ala 115 120 125 acg ccg cag gcg atg cgg att gcc aaa gat ttc ggc aag tcg ttg ggc 432 Thr Pro Gln Ala Met Arg Ile Ala Lys Asp Phe Gly Lys Ser Leu Gly 130 135 140 ggg caa aat atc ccc gtt gtg tcg ggt atg gct tcc ggt atc gat act 480 Gly Gln Asn Ile Pro Val Val Ser Gly Met Ala Ser Gly Ile Asp Thr 145 150 155 160 gcc gcc cat cag ggc gca ctg gag gca gaa ggc ggc acc atc gcc gtg 528 Ala Ala His Gln Gly Ala Leu Glu Ala Glu Gly Gly Thr Ile Ala Val 165 170 175 tgg ggg acg ggt ata gac cgc att tac ccg ccg tcc aat aaa aac ctt 576 Trp Gly Thr Gly Ile Asp Arg Ile Tyr Pro Pro Ser Asn Lys Asn Leu 180 185 190 gcc tat gaa atc gcc gaa aaa gga ttg att gtc agc gag ttt ccc atc 624 Ala Tyr Glu Ile Ala Glu Lys Gly Leu Ile Val Ser Glu Phe Pro Ile 195 200 205 ggt acg cgc ccg tat gcc ggc aat ttt ccg cgc cgc aac cgc ctg att 672 Gly Thr Arg Pro Tyr Ala Gly Asn Phe Pro Arg Arg Asn Arg Leu Ile 210 215 220 gcc gcc ctg tcg caa gta acg ctg gtg gtt gaa gcc gcc ttg gaa tcc 720 Ala Ala Leu Ser Gln Val Thr Leu Val Val Glu Ala Ala Leu Glu Ser 225 230 235 240 ggt tcg ctg att acc gcc ggc ctg gcg gca gaa atg ggg cgc gaa gtg 768 Gly Ser Leu Ile Thr Ala Gly Leu Ala Ala Glu Met Gly Arg Glu Val 245 250 255 atg gcg gta ccc ggt tcg ata gac aat ccg cac agc aaa ggc tgc cac 816 Met Ala Val Pro Gly Ser Ile Asp Asn Pro His Ser Lys Gly Cys His 260 265 270 aaa ctg att aaa gac ggc gca aaa ttg gtg gaa tgc ctg gac gac atc 864 Lys Leu Ile Lys Asp Gly Ala Lys Leu Val Glu Cys Leu Asp Asp Ile 275 280 285 ctg aac gaa tgc ccg ggg cta ttg caa aat acg ggt gct tca tca tat 912 Leu Asn Glu Cys Pro Gly Leu Leu Gln Asn Thr Gly Ala Ser Ser Tyr 290 295 300 tct ata aat aag gat acg ccc gac acg gga cgc cgc gcc gtt cag acg 960 Ser Ile Asn Lys Asp Thr Pro Asp Thr Gly Arg Arg Ala Val Gln Thr 305 310 315 320 gca tac gcc ccg ccg cct gcc gca aaa atg ccg tct gaa gcg gcg gca 1008 Ala Tyr Ala Pro Pro Pro Ala Ala Lys Met Pro Ser Glu Ala Ala Ala 325 330 335 ggc ggc aca gcc gtc ggc ggc ata ctg gat aaa atg ggt ttc gac ccc 1056 Gly Gly Thr Ala Val Gly Gly Ile Leu Asp Lys Met Gly Phe Asp Pro 340 345 350 atc cat ccc gac gtg ctt gcc gga cag ttg gct atg cct gcc gca gat 1104 Ile His Pro Asp Val Leu Ala Gly Gln Leu Ala Met Pro Ala Ala Asp 355 360 365 ttg tat gcc gca ctg ttg gaa ttg gaa ttg gac ggc agc gtt gcc gca 1152 Leu Tyr Ala Ala Leu Leu Glu Leu Glu Leu Asp Gly Ser Val Ala Ala 370 375 380 atg ccc agc ggc aga tac cag cgt atc cga act 1185 Met Pro Ser Gly Arg Tyr Gln Arg Ile Arg Thr 385 390 395 <210> 108 <211> 395 <212> PRT <213> Neisseria meningitidis <400> 108 Met Thr Glu Asp Glu Arg Phe Ala Trp Leu Gln Leu Ala Phe Thr Pro 1 5 10 15 Tyr Ile Gly Ala Glu Ser Phe Leu Leu Leu Met Arg Arg Phe Gly Ser 20 25 30 Ala Gln Asn Ala Leu Ser Ala Pro Ala Glu Gln Val Ala Ala Leu Ile 35 40 45 Arg His Lys Gln Ala Leu Glu Ala Trp Arg Asn Ala Glu Lys Arg Ala 50 55 60 Leu Ala Arg Gln Ala Ala Glu Ala Ala Leu Glu Trp Glu Met Arg Asp 65 70 75 80 Gly Cys Arg Leu Met Leu Leu Gln Asp Glu Asp Phe Pro Glu Met Leu 85 90 95 Thr Gln Gly Leu Thr Ala Pro Pro Val Leu Phe Leu Arg Gly Asn Val 100 105 110 Arg Leu Leu His Lys Pro Ser Ala Ala Ile Val Gly Ser Arg His Ala 115 120 125 Thr Pro Gln Ala Met Arg Ile Ala Lys Asp Phe Gly Lys Ser Leu Gly 130 135 140 Gly Gln Asn Ile Pro Val Val Ser Gly Met Ala Ser Gly Ile Asp Thr 145 150 155 160 Ala Ala His Gln Gly Ala Leu Glu Ala Glu Gly Gly Thr Ile Ala Val 165 170 175 Trp Gly Thr Gly Ile Asp Arg Ile Tyr Pro Pro Ser Asn Lys Asn Leu 180 185 190 Ala Tyr Glu Ile Ala Glu Lys Gly Leu Ile Val Ser Glu Phe Pro Ile 195 200 205 Gly Thr Arg Pro Tyr Ala Gly Asn Phe Pro Arg Arg Asn Arg Leu Ile 210 215 220 Ala Ala Leu Ser Gln Val Thr Leu Val Val Glu Ala Ala Leu Glu Ser 225 230 235 240 Gly Ser Leu Ile Thr Ala Gly Leu Ala Ala Glu Met Gly Arg Glu Val 245 250 255 Met Ala Val Pro Gly Ser Ile Asp Asn Pro His Ser Lys Gly Cys His 260 265 270 Lys Leu Ile Lys Asp Gly Ala Lys Leu Val Glu Cys Leu Asp Asp Ile 275 280 285 Leu Asn Glu Cys Pro Gly Leu Leu Gln Asn Thr Gly Ala Ser Ser Tyr 290 295 300 Ser Ile Asn Lys Asp Thr Pro Asp Thr Gly Arg Arg Ala Val Gln Thr 305 310 315 320 Ala Tyr Ala Pro Pro Pro Ala Ala Lys Met Pro Ser Glu Ala Ala Ala 325 330 335 Gly Gly Thr Ala Val Gly Gly Ile Leu Asp Lys Met Gly Phe Asp Pro 340 345 350 Ile His Pro Asp Val Leu Ala Gly Gln Leu Ala Met Pro Ala Ala Asp 355 360 365 Leu Tyr Ala Ala Leu Leu Glu Leu Glu Leu Asp Gly Ser Val Ala Ala 370 375 380 Met Pro Ser Gly Arg Tyr Gln Arg Ile Arg Thr 385 390 395 <210> 109 <211> 1257 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1257) <400> 109 atg aaa cag acc gtc ctc aaa aat aac ctg caa aac ctg ctt gaa agc 48 Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser 1 5 10 15 gca gaa aat atc ctg ctg ctt caa ggc cct gtc ggc gat ttt ttt ctg 96 Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu 20 25 30 cgc ctt gcc gac tgg ctg act gca aac ggc aaa acc gta cat aaa ttc 144 Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe 35 40 45 aac ttt aat gca ggc gac gac tat ttt tat ccg ccc act caa gcg cat 192 Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His 50 55 60 acc gtt gtt ttt aac gac aac tac gat gcc ttt cct gag ttt ttg caa 240 Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln 65 70 75 80 gaa tac atc act caa cat cac atc cag gcc gtt gtc tgc ttt ggc gac 288 Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp 85 90 95 aca cgc cct tat cac gtc att gca aaa cgc att gca aac gaa aac caa 336 Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln 100 105 110 gcc agt ttc tgg gcg ttt gaa gaa ggc tat ttc cgc ccc tac tac atc 384 Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile 115 120 125 acc tta gaa aaa gac ggc gtc aac gca ttt tcc ccg ttg ccg cgc cgt 432 Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg 130 135 140 gcc gac ttt ttt ctt gaa caa ttc cct aag ctt gcc cag caa gaa tat 480 Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr 145 150 155 160 aaa gcg cca acg ccg gta cac ggc ggt ttt acg ccc atg gca aaa aac 528 Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn 165 170 175 gct atc cgt tac tat atc gag ttg ttc cgc aat cta cgc aaa tac ccc 576 Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro 180 185 190 gac tac atc cac cac cgc gca ccc aat gcc ggc cat tac ctc aaa ccg 624 Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro 195 200 205 tgg tcg ctc tcc atc ctc aag cgt ttg aac tac tat att gaa gac atc 672 Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile 210 215 220 caa atc gcc aaa cgt gtg gaa gca ggc aaa tac ggc aag ttt ttt att 720 Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile 225 230 235 240 gtt ccc ttg cag gta ttc aac gac agc caa gtc cgt atc cat tgc gac 768 Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp 245 250 255 ttt ccc agc gtc cgc agc ttc ctg ctc cat gtt ttg agt tca ttt gcc 816 Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala 260 265 270 gaa cac gcg cct gcc gat acc aac atc atc atc aag cat cat cct atg 864 Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met 275 280 285 gac cgc ggc ttt atc gac tac tgg cgc gac att aaa cgc ttt atc aaa 912 Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys 290 295 300 gaa cac ccc gaa ctc aaa ggc cgt gtg att tat gtc cat gat gtc ccc 960 Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro 305 310 315 320 ctg ccc gtt ttc ctg cgc cac ggt ctc ggc atg gtt acc atc aac agc 1008 Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser 325 330 335 acc agc ggc ctg tcc gga ctg att cac aat atg cca gtt aag gtt ctc 1056 Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu 340 345 350 ggc cgt gcc tat tat gat att ccc ggc att act gac caa aat acc ttg 1104 Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu 355 360 365 gca gaa ttt tgg aat cat ccg aca ccg cct gac aaa gag ctg ttc cat 1152 Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His 370 375 380 gcc tac cga atg tac cac ctc aac gtg acc caa att aac ggc aac ttc 1200 Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe 385 390 395 400 tac agt cag gtc ttt ttt cct aac aaa aac aca tcc gac tct tcc aca 1248 Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr 405 410 415 cca aca acc 1257 Pro Thr Thr <210> 110 <211> 419 <212> PRT <213> Neisseria meningitidis <400> 110 Met Lys Gln Thr Val Leu Lys Asn Asn Leu Gln Asn Leu Leu Glu Ser 1 5 10 15 Ala Glu Asn Ile Leu Leu Leu Gln Gly Pro Val Gly Asp Phe Phe Leu 20 25 30 Arg Leu Ala Asp Trp Leu Thr Ala Asn Gly Lys Thr Val His Lys Phe 35 40 45 Asn Phe Asn Ala Gly Asp Asp Tyr Phe Tyr Pro Pro Thr Gln Ala His 50 55 60 Thr Val Val Phe Asn Asp Asn Tyr Asp Ala Phe Pro Glu Phe Leu Gln 65 70 75 80 Glu Tyr Ile Thr Gln His His Ile Gln Ala Val Val Cys Phe Gly Asp 85 90 95 Thr Arg Pro Tyr His Val Ile Ala Lys Arg Ile Ala Asn Glu Asn Gln 100 105 110 Ala Ser Phe Trp Ala Phe Glu Glu Gly Tyr Phe Arg Pro Tyr Tyr Ile 115 120 125 Thr Leu Glu Lys Asp Gly Val Asn Ala Phe Ser Pro Leu Pro Arg Arg 130 135 140 Ala Asp Phe Phe Leu Glu Gln Phe Pro Lys Leu Ala Gln Gln Glu Tyr 145 150 155 160 Lys Ala Pro Thr Pro Val His Gly Gly Phe Thr Pro Met Ala Lys Asn 165 170 175 Ala Ile Arg Tyr Tyr Ile Glu Leu Phe Arg Asn Leu Arg Lys Tyr Pro 180 185 190 Asp Tyr Ile His His Arg Ala Pro Asn Ala Gly His Tyr Leu Lys Pro 195 200 205 Trp Ser Leu Ser Ile Leu Lys Arg Leu Asn Tyr Tyr Ile Glu Asp Ile 210 215 220 Gln Ile Ala Lys Arg Val Glu Ala Gly Lys Tyr Gly Lys Phe Phe Ile 225 230 235 240 Val Pro Leu Gln Val Phe Asn Asp Ser Gln Val Arg Ile His Cys Asp 245 250 255 Phe Pro Ser Val Arg Ser Phe Leu Leu His Val Leu Ser Ser Phe Ala 260 265 270 Glu His Ala Pro Ala Asp Thr Asn Ile Ile Ile Lys His His Pro Met 275 280 285 Asp Arg Gly Phe Ile Asp Tyr Trp Arg Asp Ile Lys Arg Phe Ile Lys 290 295 300 Glu His Pro Glu Leu Lys Gly Arg Val Ile Tyr Val His Asp Val Pro 305 310 315 320 Leu Pro Val Phe Leu Arg His Gly Leu Gly Met Val Thr Ile Asn Ser 325 330 335 Thr Ser Gly Leu Ser Gly Leu Ile His Asn Met Pro Val Lys Val Leu 340 345 350 Gly Arg Ala Tyr Tyr Asp Ile Pro Gly Ile Thr Asp Gln Asn Thr Leu 355 360 365 Ala Glu Phe Trp Asn His Pro Thr Pro Pro Asp Lys Glu Leu Phe His 370 375 380 Ala Tyr Arg Met Tyr His Leu Asn Val Thr Gln Ile Asn Gly Asn Phe 385 390 395 400 Tyr Ser Gln Val Phe Phe Pro Asn Lys Asn Thr Ser Asp Ser Ser Thr 405 410 415 Pro Thr Thr <210> 111 <211> 1674 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1674) <400> 111 atg agt ttc aaa acc gat gcc gaa atc gcc caa tcc tcc acc atg cgc 48 Met Ser Phe Lys Thr Asp Ala Glu Ile Ala Gln Ser Ser Thr Met Arg 1 5 10 15 ccg att ggc gaa att gcc gcc aag ctg ggt ttg aac gtt gac aac att 96 Pro Ile Gly Glu Ile Ala Ala Lys Leu Gly Leu Asn Val Asp Asn Ile 20 25 30 gag cct tac ggt cat tac aaa gcc aaa atc aat cct gcc gaa gcg ttc 144 Glu Pro Tyr Gly His Tyr Lys Ala Lys Ile Asn Pro Ala Glu Ala Phe 35 40 45 aaa ctg ccg caa aaa cag ggc agg ctg att ttg gtt acc gcc atc aac 192 Lys Leu Pro Gln Lys Gln Gly Arg Leu Ile Leu Val Thr Ala Ile Asn 50 55 60 ccg act ccg gcg ggc gaa ggt aaa acc acc gta acc atc ggt ttg gcg 240 Pro Thr Pro Ala Gly Glu Gly Lys Thr Thr Val Thr Ile Gly Leu Ala 65 70 75 80 gac gca ttg cgc cat atc ggc aaa gac tct gtg att gct ttg cgc gag 288 Asp Ala Leu Arg His Ile Gly Lys Asp Ser Val Ile Ala Leu Arg Glu 85 90 95 cct tct ttg ggt ccg gtg ttc ggc gtg aaa ggc ggc gcg gca ggc ggc 336 Pro Ser Leu Gly Pro Val Phe Gly Val Lys Gly Gly Ala Ala Gly Gly 100 105 110 ggc tat gcc caa gtt ttg ccg atg gaa gac atc aac ctg cac ttc acc 384 Gly Tyr Ala Gln Val Leu Pro Met Glu Asp Ile Asn Leu His Phe Thr 115 120 125 gga gat ttt cac gcc atc ggt gcg gca aat aat ctg ctt gcc gcg atg 432 Gly Asp Phe His Ala Ile Gly Ala Ala Asn Asn Leu Leu Ala Ala Met 130 135 140 ctc gac aac cat atc tac caa ggc aac gag ttg aac atc gac ccc aaa 480 Leu Asp Asn His Ile Tyr Gln Gly Asn Glu Leu Asn Ile Asp Pro Lys 145 150 155 160 cgc gtg ctg tgg cgg cgc gtg gtc gat atg aac gac cgc cag ttg cgc 528 Arg Val Leu Trp Arg Arg Val Val Asp Met Asn Asp Arg Gln Leu Arg 165 170 175 aac atc atc gac ggc atg ggc aag cct gtt gac ggc gtg atg cgt cct 576 Asn Ile Ile Asp Gly Met Gly Lys Pro Val Asp Gly Val Met Arg Pro 180 185 190 gac ggt ttc gat att acc gtt gct tcc gaa gtg atg gcg gta ttc tgt 624 Asp Gly Phe Asp Ile Thr Val Ala Ser Glu Val Met Ala Val Phe Cys 195 200 205 ctt gcc aaa gac atc agc gat ttg aaa gag cgt ttg ggc aac atc ctt 672 Leu Ala Lys Asp Ile Ser Asp Leu Lys Glu Arg Leu Gly Asn Ile Leu 210 215 220 gtc gcc tac gcc aaa gac ggc agc ccc gtt tac gcc aaa gat ttg aaa 720 Val Ala Tyr Ala Lys Asp Gly Ser Pro Val Tyr Ala Lys Asp Leu Lys 225 230 235 240 gcg aat ggc gcg atg gcg gca ttg ctt aaa gat gcg att aag ccc aac 768 Ala Asn Gly Ala Met Ala Ala Leu Leu Lys Asp Ala Ile Lys Pro Asn 245 250 255 ttg gtg caa acc atc gaa ggc acg ccc gcc ttc gta cac ggc ggc ccg 816 Leu Val Gln Thr Ile Glu Gly Thr Pro Ala Phe Val His Gly Gly Pro 260 265 270 ttc gcc aac atc gcc cac ggc tgc aac tcc gta acc gca acc cgt ctg 864 Phe Ala Asn Ile Ala His Gly Cys Asn Ser Val Thr Ala Thr Arg Leu 275 280 285 gcg aaa cac ctt gcc gat tac gcc gta acc gaa gca ggc ttc ggc gcg 912 Ala Lys His Leu Ala Asp Tyr Ala Val Thr Glu Ala Gly Phe Gly Ala 290 295 300 gac ttg ggc gcg gaa aaa ttc tgc gac atc aaa tgc cgc ctt gcc ggt 960 Asp Leu Gly Ala Glu Lys Phe Cys Asp Ile Lys Cys Arg Leu Ala Gly 305 310 315 320 ttg aaa cct gat gcg gct gtt gtc gtg gcg act gtc cgc gcg ttg aaa 1008 Leu Lys Pro Asp Ala Ala Val Val Val Ala Thr Val Arg Ala Leu Lys 325 330 335 tat aac ggc ggc gtg gaa cgc gcc aac ctc ggc gaa gaa aat tta gac 1056 Tyr Asn Gly Gly Val Glu Arg Ala Asn Leu Gly Glu Glu Asn Leu Asp 340 345 350 gct ttg gaa aaa ggt ttg ccc aac ctg ctg aaa cac att tcc aac ctg 1104 Ala Leu Glu Lys Gly Leu Pro Asn Leu Leu Lys His Ile Ser Asn Leu 355 360 365 aaa aac gta ttc gga ctg ccc gtc gtc gtt gcg ctc aac cgc ttc gtg 1152 Lys Asn Val Phe Gly Leu Pro Val Val Val Ala Leu Asn Arg Phe Val 370 375 380 tcc gac tcc gat gcc gag ttg gcg atg att gaa aaa gcc tgt gcc gaa 1200 Ser Asp Ser Asp Ala Glu Leu Ala Met Ile Glu Lys Ala Cys Ala Glu 385 390 395 400 cac ggc gtt gaa gtt tcc ctg acc gaa gtg tgg ggc aaa ggt ggt gcg 1248 His Gly Val Glu Val Ser Leu Thr Glu Val Trp Gly Lys Gly Gly Ala 405 410 415 ggc ggc gcg gat ttg gcg cgc aaa gtc gtc aac gcc att gaa agt caa 1296 Gly Gly Ala Asp Leu Ala Arg Lys Val Val Asn Ala Ile Glu Ser Gln 420 425 430 acc aat aac ttc ggt ttc gcc tac gat gtc gag ttg ggc atc aaa gac 1344 Thr Asn Asn Phe Gly Phe Ala Tyr Asp Val Glu Leu Gly Ile Lys Asp 435 440 445 aaa atc cgt gcg att gcc caa aaa gtg tac ggc gcg gaa gat gtt gat 1392 Lys Ile Arg Ala Ile Ala Gln Lys Val Tyr Gly Ala Glu Asp Val Asp 450 455 460 ttc agc gcg gaa gcg tct gcc gaa atc gct tca ctg gaa aaa ctg ggc 1440 Phe Ser Ala Glu Ala Ser Ala Glu Ile Ala Ser Leu Glu Lys Leu Gly 465 470 475 480 ttg gac aaa atg ccg atc tgc atg gcg aaa acc caa tac tct ttg agc 1488 Leu Asp Lys Met Pro Ile Cys Met Ala Lys Thr Gln Tyr Ser Leu Ser 485 490 495 gac aac gcc aaa ctg ttg ggc tgc ccc gaa gac ttc cgc atc gcc gtg 1536 Asp Asn Ala Lys Leu Leu Gly Cys Pro Glu Asp Phe Arg Ile Ala Val 500 505 510 cgc ggc atc acc gtt tcc gca ggc gca ggt ttc atc gtc gcc ctg tgc 1584 Arg Gly Ile Thr Val Ser Ala Gly Ala Gly Phe Ile Val Ala Leu Cys 515 520 525 ggc aac atg atg aaa atg ccc ggc ctg ccc aaa gtt ccg gct gcc gag 1632 Gly Asn Met Met Lys Met Pro Gly Leu Pro Lys Val Pro Ala Ala Glu 530 535 540 aaa atc gat gtg gac gca gaa ggc gtg att cac ggc ttg ttc 1674 Lys Ile Asp Val Asp Ala Glu Gly Val Ile His Gly Leu Phe 545 550 555 <210> 112 <211> 558 <212> PRT <213> Neisseria meningitidis <400> 112 Met Ser Phe Lys Thr Asp Ala Glu Ile Ala Gln Ser Ser Thr Met Arg 1 5 10 15 Pro Ile Gly Glu Ile Ala Ala Lys Leu Gly Leu Asn Val Asp Asn Ile 20 25 30 Glu Pro Tyr Gly His Tyr Lys Ala Lys Ile Asn Pro Ala Glu Ala Phe 35 40 45 Lys Leu Pro Gln Lys Gln Gly Arg Leu Ile Leu Val Thr Ala Ile Asn 50 55 60 Pro Thr Pro Ala Gly Glu Gly Lys Thr Thr Val Thr Ile Gly Leu Ala 65 70 75 80 Asp Ala Leu Arg His Ile Gly Lys Asp Ser Val Ile Ala Leu Arg Glu 85 90 95 Pro Ser Leu Gly Pro Val Phe Gly Val Lys Gly Gly Ala Ala Gly Gly 100 105 110 Gly Tyr Ala Gln Val Leu Pro Met Glu Asp Ile Asn Leu His Phe Thr 115 120 125 Gly Asp Phe His Ala Ile Gly Ala Ala Asn Asn Leu Leu Ala Ala Met 130 135 140 Leu Asp Asn His Ile Tyr Gln Gly Asn Glu Leu Asn Ile Asp Pro Lys 145 150 155 160 Arg Val Leu Trp Arg Arg Val Val Asp Met Asn Asp Arg Gln Leu Arg 165 170 175 Asn Ile Ile Asp Gly Met Gly Lys Pro Val Asp Gly Val Met Arg Pro 180 185 190 Asp Gly Phe Asp Ile Thr Val Ala Ser Glu Val Met Ala Val Phe Cys 195 200 205 Leu Ala Lys Asp Ile Ser Asp Leu Lys Glu Arg Leu Gly Asn Ile Leu 210 215 220 Val Ala Tyr Ala Lys Asp Gly Ser Pro Val Tyr Ala Lys Asp Leu Lys 225 230 235 240 Ala Asn Gly Ala Met Ala Ala Leu Leu Lys Asp Ala Ile Lys Pro Asn 245 250 255 Leu Val Gln Thr Ile Glu Gly Thr Pro Ala Phe Val His Gly Gly Pro 260 265 270 Phe Ala Asn Ile Ala His Gly Cys Asn Ser Val Thr Ala Thr Arg Leu 275 280 285 Ala Lys His Leu Ala Asp Tyr Ala Val Thr Glu Ala Gly Phe Gly Ala 290 295 300 Asp Leu Gly Ala Glu Lys Phe Cys Asp Ile Lys Cys Arg Leu Ala Gly 305 310 315 320 Leu Lys Pro Asp Ala Ala Val Val Val Ala Thr Val Arg Ala Leu Lys 325 330 335 Tyr Asn Gly Gly Val Glu Arg Ala Asn Leu Gly Glu Glu Asn Leu Asp 340 345 350 Ala Leu Glu Lys Gly Leu Pro Asn Leu Leu Lys His Ile Ser Asn Leu 355 360 365 Lys Asn Val Phe Gly Leu Pro Val Val Val Ala Leu Asn Arg Phe Val 370 375 380 Ser Asp Ser Asp Ala Glu Leu Ala Met Ile Glu Lys Ala Cys Ala Glu 385 390 395 400 His Gly Val Glu Val Ser Leu Thr Glu Val Trp Gly Lys Gly Gly Ala 405 410 415 Gly Gly Ala Asp Leu Ala Arg Lys Val Val Asn Ala Ile Glu Ser Gln 420 425 430 Thr Asn Asn Phe Gly Phe Ala Tyr Asp Val Glu Leu Gly Ile Lys Asp 435 440 445 Lys Ile Arg Ala Ile Ala Gln Lys Val Tyr Gly Ala Glu Asp Val Asp 450 455 460 Phe Ser Ala Glu Ala Ser Ala Glu Ile Ala Ser Leu Glu Lys Leu Gly 465 470 475 480 Leu Asp Lys Met Pro Ile Cys Met Ala Lys Thr Gln Tyr Ser Leu Ser 485 490 495 Asp Asn Ala Lys Leu Leu Gly Cys Pro Glu Asp Phe Arg Ile Ala Val 500 505 510 Arg Gly Ile Thr Val Ser Ala Gly Ala Gly Phe Ile Val Ala Leu Cys 515 520 525 Gly Asn Met Met Lys Met Pro Gly Leu Pro Lys Val Pro Ala Ala Glu 530 535 540 Lys Ile Asp Val Asp Ala Glu Gly Val Ile His Gly Leu Phe 545 550 555 <210> 113 <211> 475 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(474) <400> 113 atg gaa cac cta ttt gag gaa tgg ttg ccc gac ctg ccc gcc gac gtt 48 Met Glu His Leu Phe Glu Glu Trp Leu Pro Asp Leu Pro Ala Asp Val 1 5 10 15 tca gac ggc atc ggc ctg ccg atg agc cgg tta ttg aaa gcc cgg tcg 96 Ser Asp Gly Ile Gly Leu Pro Met Ser Arg Leu Leu Lys Ala Arg Ser 20 25 30 ctg act gcc gca ttg cgc gcc ttg ccg cat ctg ttt tcg gta gaa ctg 144 Leu Thr Ala Ala Leu Arg Ala Leu Pro His Leu Phe Ser Val Glu Leu 35 40 45 ctg aaa ctg ggc gaa ttg gaa acg gaa tgc gga ggg cgg ctg gtg cgc 192 Leu Lys Leu Gly Glu Leu Glu Thr Glu Cys Gly Gly Arg Leu Val Arg 50 55 60 gaa gtt ttg ttg aag ctg gac ggt atc cct gtt gtc gcg gca agg agc 240 Glu Val Leu Leu Lys Leu Asp Gly Ile Pro Val Val Ala Ala Arg Ser 65 70 75 80 gaa tgc cgt atc ggt tcg gcg ttt tgg caa aac att ttg gac tgc ggc 288 Glu Cys Arg Ile Gly Ser Ala Phe Trp Gln Asn Ile Leu Asp Cys Gly 85 90 95 acg cgt cct ttg ggc gaa cgt ctg ttt caa gcc gat ttg gaa ggg gcg 336 Thr Arg Pro Leu Gly Glu Arg Leu Phe Gln Ala Asp Leu Glu Gly Ala 100 105 110 cgt tcg gcg ttt gag ttt gcc gtt ttc ggc gaa gga tgc gga cgg tac 384 Arg Ser Ala Phe Glu Phe Ala Val Phe Gly Glu Gly Cys Gly Arg Tyr 115 120 125 ttt gcc gct cgg cgt tcg cgg ttt tcc cat cac ggc gag gaa atg ctg 432 Phe Ala Ala Arg Arg Ser Arg Phe Ser His His Gly Glu Glu Met Leu 130 135 140 ctg acc gag tat ttt ctg ccc gaa ctg aaa cgc ttt atc gga t 475 Leu Thr Glu Tyr Phe Leu Pro Glu Leu Lys Arg Phe Ile Gly 145 150 155 <210> 114 <211> 158 <212> PRT <213> Neisseria meningitidis <400> 114 Met Glu His Leu Phe Glu Glu Trp Leu Pro Asp Leu Pro Ala Asp Val 1 5 10 15 Ser Asp Gly Ile Gly Leu Pro Met Ser Arg Leu Leu Lys Ala Arg Ser 20 25 30 Leu Thr Ala Ala Leu Arg Ala Leu Pro His Leu Phe Ser Val Glu Leu 35 40 45 Leu Lys Leu Gly Glu Leu Glu Thr Glu Cys Gly Gly Arg Leu Val Arg 50 55 60 Glu Val Leu Leu Lys Leu Asp Gly Ile Pro Val Val Ala Ala Arg Ser 65 70 75 80 Glu Cys Arg Ile Gly Ser Ala Phe Trp Gln Asn Ile Leu Asp Cys Gly 85 90 95 Thr Arg Pro Leu Gly Glu Arg Leu Phe Gln Ala Asp Leu Glu Gly Ala 100 105 110 Arg Ser Ala Phe Glu Phe Ala Val Phe Gly Glu Gly Cys Gly Arg Tyr 115 120 125 Phe Ala Ala Arg Arg Ser Arg Phe Ser His His Gly Glu Glu Met Leu 130 135 140 Leu Thr Glu Tyr Phe Leu Pro Glu Leu Lys Arg Phe Ile Gly 145 150 155 <210> 115 <211> 1476 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1476) <400> 115 atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag 48 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg 96 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg 144 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg 192 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc 240 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat 288 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa 336 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa 384 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg 432 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg 480 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa 528 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att 576 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc 624 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc 672 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc 720 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa 768 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa 816 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcg ttg gaa ggt 864 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc 912 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac 960 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg 1008 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 gcg ttg aac gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa 1056 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg 1104 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg 1152 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc 1200 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc 1248 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg 1296 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga 1344 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa 1392 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg 1440 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 gct aag att gat gag att tgg gag gaa ttg ggg ttg 1476 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 116 <211> 492 <212> PRT <213> Neisseria meningitidis <400> 116 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 117 <211> 1515 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1515) <400> 117 atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt 48 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag 96 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg 144 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt 192 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc 240 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc 288 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg 336 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg 384 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg 432 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat 480 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat 528 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt 576 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg 624 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc 672 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa 720 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc 768 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg 816 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg 864 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc 912 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat 960 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca 1008 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc 1056 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg 1104 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc 1152 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc 1200 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc 1248 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc 1296 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca 1344 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac 1392 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc 1440 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag 1488 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 gtg ttt gtg tcg gcg gat tgg cgg ttt 1515 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 118 <211> 505 <212> PRT <213> Neisseria meningitidis <400> 118 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 119 <211> 756 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(756) <400> 119 atg gaa acg cat tcg ggc tgt ttt ttg cgg aag acg gta atg aaa gac 48 Met Glu Thr His Ser Gly Cys Phe Leu Arg Lys Thr Val Met Lys Asp 1 5 10 15 gat gtt ttg aaa cag cag gca cac gcg gcg ata cag aag aaa ctg ggc 96 Asp Val Leu Lys Gln Gln Ala His Ala Ala Ile Gln Lys Lys Leu Gly 20 25 30 tac gcg ttc cgc gat att tcg ctt ttg cgg cag gct ttg acg cac agg 144 Tyr Ala Phe Arg Asp Ile Ser Leu Leu Arg Gln Ala Leu Thr His Arg 35 40 45 agc cat cat gcg aag cac aac gag cgg ttc gag ttt gtc ggc gat tcg 192 Ser His His Ala Lys His Asn Glu Arg Phe Glu Phe Val Gly Asp Ser 50 55 60 att ttg aat tat acg gtg gcg cgg atg ctg ttt gac gcg ttt ccg aag 240 Ile Leu Asn Tyr Thr Val Ala Arg Met Leu Phe Asp Ala Phe Pro Lys 65 70 75 80 ttg acc gag ggc gag ttg tcg cgg ttg cgg gca agt ctg gtc aat gag 288 Leu Thr Glu Gly Glu Leu Ser Arg Leu Arg Ala Ser Leu Val Asn Glu 85 90 95 ggc gtg ctg gcg gaa atg gcg gcg gaa atg aat gtc ggc gac ggc ctg 336 Gly Val Leu Ala Glu Met Ala Ala Glu Met Asn Val Gly Asp Gly Leu 100 105 110 tac ttg ggg gcg ggc gag ttg aag agc ggc ggc ttc aga cgg cct tcg 384 Tyr Leu Gly Ala Gly Glu Leu Lys Ser Gly Gly Phe Arg Arg Pro Ser 115 120 125 ata ctg gcg gac gcg atg gag gcg atg ttt gcg gcg gtc agc ttc gat 432 Ile Leu Ala Asp Ala Met Glu Ala Met Phe Ala Ala Val Ser Phe Asp 130 135 140 gcg gat ttc aac acg gcg gaa aag gtg gtg cgc cat ttg ttt gca gaa 480 Ala Asp Phe Asn Thr Ala Glu Lys Val Val Arg His Leu Phe Ala Glu 145 150 155 160 cgc gtc cgg cga gtc gat ttc caa aat cag gca aaa gac ggc aaa act 528 Arg Val Arg Arg Val Asp Phe Gln Asn Gln Ala Lys Asp Gly Lys Thr 165 170 175 gct ttg cag gag gcg ttg cag gcg cgc cgt ttc gcc ttg ccg aaa tac 576 Ala Leu Gln Glu Ala Leu Gln Ala Arg Arg Phe Ala Leu Pro Lys Tyr 180 185 190 cgt atc gaa gag caa atc ggc cat gcc aac gac agt atg ttt gtc att 624 Arg Ile Glu Glu Gln Ile Gly His Ala Asn Asp Ser Met Phe Val Ile 195 200 205 tcc tgc gat ttg ggc gaa ctg ggt ttc gtg tgc cgt gcc aaa ggg acg 672 Ser Cys Asp Leu Gly Glu Leu Gly Phe Val Cys Arg Ala Lys Gly Thr 210 215 220 agc cgc aag gcg gcg gag cag gaa gcg gcg aaa gag gct ttg aaa tgg 720 Ser Arg Lys Ala Ala Glu Gln Glu Ala Ala Lys Glu Ala Leu Lys Trp 225 230 235 240 ctg gaa gag aag ctg ccg ctg aag aag aaa aag aaa 756 Leu Glu Glu Lys Leu Pro Leu Lys Lys Lys Lys Lys 245 250 <210> 120 <211> 252 <212> PRT <213> Neisseria meningitidis <400> 120 Met Glu Thr His Ser Gly Cys Phe Leu Arg Lys Thr Val Met Lys Asp 1 5 10 15 Asp Val Leu Lys Gln Gln Ala His Ala Ala Ile Gln Lys Lys Leu Gly 20 25 30 Tyr Ala Phe Arg Asp Ile Ser Leu Leu Arg Gln Ala Leu Thr His Arg 35 40 45 Ser His His Ala Lys His Asn Glu Arg Phe Glu Phe Val Gly Asp Ser 50 55 60 Ile Leu Asn Tyr Thr Val Ala Arg Met Leu Phe Asp Ala Phe Pro Lys 65 70 75 80 Leu Thr Glu Gly Glu Leu Ser Arg Leu Arg Ala Ser Leu Val Asn Glu 85 90 95 Gly Val Leu Ala Glu Met Ala Ala Glu Met Asn Val Gly Asp Gly Leu 100 105 110 Tyr Leu Gly Ala Gly Glu Leu Lys Ser Gly Gly Phe Arg Arg Pro Ser 115 120 125 Ile Leu Ala Asp Ala Met Glu Ala Met Phe Ala Ala Val Ser Phe Asp 130 135 140 Ala Asp Phe Asn Thr Ala Glu Lys Val Val Arg His Leu Phe Ala Glu 145 150 155 160 Arg Val Arg Arg Val Asp Phe Gln Asn Gln Ala Lys Asp Gly Lys Thr 165 170 175 Ala Leu Gln Glu Ala Leu Gln Ala Arg Arg Phe Ala Leu Pro Lys Tyr 180 185 190 Arg Ile Glu Glu Gln Ile Gly His Ala Asn Asp Ser Met Phe Val Ile 195 200 205 Ser Cys Asp Leu Gly Glu Leu Gly Phe Val Cys Arg Ala Lys Gly Thr 210 215 220 Ser Arg Lys Ala Ala Glu Gln Glu Ala Ala Lys Glu Ala Leu Lys Trp 225 230 235 240 Leu Glu Glu Lys Leu Pro Leu Lys Lys Lys Lys Lys 245 250 <210> 121 <211> 570 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(570) <400> 121 atg gac aat cac gcc gaa gca cac tgg caa aac ggc tgg ctt caa agc 48 Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser 1 5 10 15 ata cgc cat acc ccg tcg ccc aat ttc agc ccg agg gaa acg ggg gaa 96 Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu 20 25 30 acg gtt tcc ctg atc gtg ttg cac aac att tca ctg ccg ccg ttc gaa 144 Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu 35 40 45 tac ggc acg gat gct gtg gaa aag ctg ttt gcc aac cgg ctc gac ccc 192 Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro 50 55 60 aac gga cat ccg ttc ttc agc ctg ata cac act ttg cgc gta tcc agc 240 Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser 65 70 75 80 cat ttc tta atc aaa cgc gac ggc aaa acg gtg cag ttc gta tca tgc 288 His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys 85 90 95 ggc gat atg gcg tac cac gcg ggc gta tcc tcg ttt cgc gga cgg gaa 336 Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu 100 105 110 aaa tgc aac gca ttt tcc atc ggc atc gaa ttg gaa ggc tgc gat ttc 384 Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe 115 120 125 gaa ccc ttt acc gaa gcg caa tac cgt tcg ctc gaa aca ttg ttg gaa 432 Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu 130 135 140 gca ctc tgc cgc cgc tac ccc gtt acc gca gta acc gga cat cag gac 480 Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp 145 150 155 160 atc gcg ccc ggc cgc aaa acc gac ccc ggc cac ttt ttc gac tgg cgg 528 Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg 165 170 175 cgg ata cgg gag aaa ggg ttt ccc gta gac aga aat gcc gtc 570 Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val 180 185 190 <210> 122 <211> 190 <212> PRT <213> Neisseria meningitidis <400> 122 Met Asp Asn His Ala Glu Ala His Trp Gln Asn Gly Trp Leu Gln Ser 1 5 10 15 Ile Arg His Thr Pro Ser Pro Asn Phe Ser Pro Arg Glu Thr Gly Glu 20 25 30 Thr Val Ser Leu Ile Val Leu His Asn Ile Ser Leu Pro Pro Phe Glu 35 40 45 Tyr Gly Thr Asp Ala Val Glu Lys Leu Phe Ala Asn Arg Leu Asp Pro 50 55 60 Asn Gly His Pro Phe Phe Ser Leu Ile His Thr Leu Arg Val Ser Ser 65 70 75 80 His Phe Leu Ile Lys Arg Asp Gly Lys Thr Val Gln Phe Val Ser Cys 85 90 95 Gly Asp Met Ala Tyr His Ala Gly Val Ser Ser Phe Arg Gly Arg Glu 100 105 110 Lys Cys Asn Ala Phe Ser Ile Gly Ile Glu Leu Glu Gly Cys Asp Phe 115 120 125 Glu Pro Phe Thr Glu Ala Gln Tyr Arg Ser Leu Glu Thr Leu Leu Glu 130 135 140 Ala Leu Cys Arg Arg Tyr Pro Val Thr Ala Val Thr Gly His Gln Asp 145 150 155 160 Ile Ala Pro Gly Arg Lys Thr Asp Pro Gly His Phe Phe Asp Trp Arg 165 170 175 Arg Ile Arg Glu Lys Gly Phe Pro Val Asp Arg Asn Ala Val 180 185 190 <210> 123 <211> 2274 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2274) <400> 123 atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc 48 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag 96 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa 144 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act 192 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc 240 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc 288 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa 336 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat 384 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa 432 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg 480 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt 528 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act 576 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct 624 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt 672 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac 720 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt 768 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg 816 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc 864 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt 912 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg 960 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc 1008 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc 1056 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct 1104 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc 1152 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat 1200 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc 1248 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac 1296 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc 1344 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa 1392 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac 1440 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc 1488 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa 1536 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta 1584 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc 1632 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att 1680 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt 1728 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa 1776 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc 1824 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc 1872 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc 1920 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att 1968 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac 2016 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc 2064 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc 2112 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa 2160 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa 2208 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg 2256 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 cgt gcc gaa ttg gcg aaa 2274 Arg Ala Glu Leu Ala Lys 755 <210> 124 <211> 758 <212> PRT <213> Neisseria meningitidis <400> 124 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 Arg Ala Glu Leu Ala Lys 755 <210> 125 <211> 1137 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1137) <400> 125 atg agc cgt tta tgg ttt ttt gcc gca aaa aac att ata atc cgc ctt 48 Met Ser Arg Leu Trp Phe Phe Ala Ala Lys Asn Ile Ile Ile Arg Leu 1 5 10 15 att tac cta ttg ccc aag gag aca caa atg gca ctc gta tcc atg cgc 96 Ile Tyr Leu Leu Pro Lys Glu Thr Gln Met Ala Leu Val Ser Met Arg 20 25 30 caa ctg ctt gat cat gct gcc gaa aac agc tac ggc ctg ccc gcg ttc 144 Gln Leu Leu Asp His Ala Ala Glu Asn Ser Tyr Gly Leu Pro Ala Phe 35 40 45 aac gtc aac aac ctc gaa caa atg cgc gcc att atg gaa gcc gcc gac 192 Asn Val Asn Asn Leu Glu Gln Met Arg Ala Ile Met Glu Ala Ala Asp 50 55 60 caa gtc aac gcg ccc gtc atc gta cag gcg agc gca ggt gcg cgc aaa 240 Gln Val Asn Ala Pro Val Ile Val Gln Ala Ser Ala Gly Ala Arg Lys 65 70 75 80 tac gcg ggc gcg ccg ttt ttg cgc cac ctg att ttg gcg gct gtc gaa 288 Tyr Ala Gly Ala Pro Phe Leu Arg His Leu Ile Leu Ala Ala Val Glu 85 90 95 gaa ttt ccg cac atc ccc gtc gtg atg cac caa gac cac ggc gca tcg 336 Glu Phe Pro His Ile Pro Val Val Met His Gln Asp His Gly Ala Ser 100 105 110 ccc gac gtg tgc caa cgc tcc atc caa ctg ggc ttt tcc tcc gtg atg 384 Pro Asp Val Cys Gln Arg Ser Ile Gln Leu Gly Phe Ser Ser Val Met 115 120 125 atg gac ggc tcg ctg atg gaa gac ggc aaa acc cct tct tct tat gaa 432 Met Asp Gly Ser Leu Met Glu Asp Gly Lys Thr Pro Ser Ser Tyr Glu 130 135 140 tac aac gtc aac gcc acc cgt acc gtg gtt aat ttc tcc cac gcc tgc 480 Tyr Asn Val Asn Ala Thr Arg Thr Val Val Asn Phe Ser His Ala Cys 145 150 155 160 ggc gta tcc gtt gaa ggc gaa atc ggc gta ttg ggc aac ctc gaa act 528 Gly Val Ser Val Glu Gly Glu Ile Gly Val Leu Gly Asn Leu Glu Thr 165 170 175 ggc gaa gcc ggc gaa gaa gac ggt gta ggc gca gtg ggc aaa ctt tcc 576 Gly Glu Ala Gly Glu Glu Asp Gly Val Gly Ala Val Gly Lys Leu Ser 180 185 190 cac gac caa atg ctc acc agc gtc gaa gat gcc gtg cgt ttc gtt aaa 624 His Asp Gln Met Leu Thr Ser Val Glu Asp Ala Val Arg Phe Val Lys 195 200 205 gat acc ggc gtt gac gca ttg gcg att gcc gtc ggc acc agc cac ggc 672 Asp Thr Gly Val Asp Ala Leu Ala Ile Ala Val Gly Thr Ser His Gly 210 215 220 gcg tac aaa ttc acc cgt ccg ccc aca ggc gac gtg ttg cgt atc gac 720 Ala Tyr Lys Phe Thr Arg Pro Pro Thr Gly Asp Val Leu Arg Ile Asp 225 230 235 240 cgc atc aaa gaa atc cac caa gcc ctg ccc aat aca cac atc gtg atg 768 Arg Ile Lys Glu Ile His Gln Ala Leu Pro Asn Thr His Ile Val Met 245 250 255 cac ggc tcc agc tcc gtt ccg caa gaa tgg ctg aaa gtc atc aac gaa 816 His Gly Ser Ser Ser Val Pro Gln Glu Trp Leu Lys Val Ile Asn Glu 260 265 270 tac ggc ggc aat atc ggc gaa acc tac ggc gtg ccg gtt gaa gaa atc 864 Tyr Gly Gly Asn Ile Gly Glu Thr Tyr Gly Val Pro Val Glu Glu Ile 275 280 285 gtc gaa ggc atc aaa cac ggc gtg cgt aaa gtc aac atc gat acc gac 912 Val Glu Gly Ile Lys His Gly Val Arg Lys Val Asn Ile Asp Thr Asp 290 295 300 ttg cgc ctt gct tcc acc ggc gcg gta cgc cgc tac ctt gcc gaa aac 960 Leu Arg Leu Ala Ser Thr Gly Ala Val Arg Arg Tyr Leu Ala Glu Asn 305 310 315 320 ccg tcc gac ttc gat ccg cgc aaa tat ttg agc aaa acc att gaa gcg 1008 Pro Ser Asp Phe Asp Pro Arg Lys Tyr Leu Ser Lys Thr Ile Glu Ala 325 330 335 atg aag caa atc tgc ctc gac cgc tac ctc gcg ttc ggt tgc gaa ggt 1056 Met Lys Gln Ile Cys Leu Asp Arg Tyr Leu Ala Phe Gly Cys Glu Gly 340 345 350 cag gca ggc aaa atc aaa ccg gtt tcc ttg gaa aaa atg gca aac cgt 1104 Gln Ala Gly Lys Ile Lys Pro Val Ser Leu Glu Lys Met Ala Asn Arg 355 360 365 tat gcc aag ggc gaa ttg aac caa atc gtc aaa 1137 Tyr Ala Lys Gly Glu Leu Asn Gln Ile Val Lys 370 375 <210> 126 <211> 379 <212> PRT <213> Neisseria meningitidis <400> 126 Met Ser Arg Leu Trp Phe Phe Ala Ala Lys Asn Ile Ile Ile Arg Leu 1 5 10 15 Ile Tyr Leu Leu Pro Lys Glu Thr Gln Met Ala Leu Val Ser Met Arg 20 25 30 Gln Leu Leu Asp His Ala Ala Glu Asn Ser Tyr Gly Leu Pro Ala Phe 35 40 45 Asn Val Asn Asn Leu Glu Gln Met Arg Ala Ile Met Glu Ala Ala Asp 50 55 60 Gln Val Asn Ala Pro Val Ile Val Gln Ala Ser Ala Gly Ala Arg Lys 65 70 75 80 Tyr Ala Gly Ala Pro Phe Leu Arg His Leu Ile Leu Ala Ala Val Glu 85 90 95 Glu Phe Pro His Ile Pro Val Val Met His Gln Asp His Gly Ala Ser 100 105 110 Pro Asp Val Cys Gln Arg Ser Ile Gln Leu Gly Phe Ser Ser Val Met 115 120 125 Met Asp Gly Ser Leu Met Glu Asp Gly Lys Thr Pro Ser Ser Tyr Glu 130 135 140 Tyr Asn Val Asn Ala Thr Arg Thr Val Val Asn Phe Ser His Ala Cys 145 150 155 160 Gly Val Ser Val Glu Gly Glu Ile Gly Val Leu Gly Asn Leu Glu Thr 165 170 175 Gly Glu Ala Gly Glu Glu Asp Gly Val Gly Ala Val Gly Lys Leu Ser 180 185 190 His Asp Gln Met Leu Thr Ser Val Glu Asp Ala Val Arg Phe Val Lys 195 200 205 Asp Thr Gly Val Asp Ala Leu Ala Ile Ala Val Gly Thr Ser His Gly 210 215 220 Ala Tyr Lys Phe Thr Arg Pro Pro Thr Gly Asp Val Leu Arg Ile Asp 225 230 235 240 Arg Ile Lys Glu Ile His Gln Ala Leu Pro Asn Thr His Ile Val Met 245 250 255 His Gly Ser Ser Ser Val Pro Gln Glu Trp Leu Lys Val Ile Asn Glu 260 265 270 Tyr Gly Gly Asn Ile Gly Glu Thr Tyr Gly Val Pro Val Glu Glu Ile 275 280 285 Val Glu Gly Ile Lys His Gly Val Arg Lys Val Asn Ile Asp Thr Asp 290 295 300 Leu Arg Leu Ala Ser Thr Gly Ala Val Arg Arg Tyr Leu Ala Glu Asn 305 310 315 320 Pro Ser Asp Phe Asp Pro Arg Lys Tyr Leu Ser Lys Thr Ile Glu Ala 325 330 335 Met Lys Gln Ile Cys Leu Asp Arg Tyr Leu Ala Phe Gly Cys Glu Gly 340 345 350 Gln Ala Gly Lys Ile Lys Pro Val Ser Leu Glu Lys Met Ala Asn Arg 355 360 365 Tyr Ala Lys Gly Glu Leu Asn Gln Ile Val Lys 370 375 <210> 127 <211> 444 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(444) <400> 127 gtg gat gct gca gca acg ctc ctg aca tac aaa tgc ccg gcg gaa aac 48 Val Asp Ala Ala Ala Thr Leu Leu Thr Tyr Lys Cys Pro Ala Glu Asn 1 5 10 15 cgc cca aac aca aaa aaa att ggt aat ttt tcc tat tca agg cta caa 96 Arg Pro Asn Thr Lys Lys Ile Gly Asn Phe Ser Tyr Ser Arg Leu Gln 20 25 30 ttc gac acg cac agg gca tct gcc cga ttt cac aat cat aat agc gga 144 Phe Asp Thr His Arg Ala Ser Ala Arg Phe His Asn His Asn Ser Gly 35 40 45 gtt aaa aat atg aca gct aaa gga caa atg ttg caa gat ccc ttc ctg 192 Val Lys Asn Met Thr Ala Lys Gly Gln Met Leu Gln Asp Pro Phe Leu 50 55 60 aac gcc ctg cgt aaa gag cat gtt ccg gtt tcg att tac tta gtt aac 240 Asn Ala Leu Arg Lys Glu His Val Pro Val Ser Ile Tyr Leu Val Asn 65 70 75 80 ggt atc aaa ttg caa ggt cag gtt gag tct ttc gat caa tac gtt gtt 288 Gly Ile Lys Leu Gln Gly Gln Val Glu Ser Phe Asp Gln Tyr Val Val 85 90 95 ctc ctg aga aac act tcc gtc acc caa atg gtt tac aaa cac gcc att 336 Leu Leu Arg Asn Thr Ser Val Thr Gln Met Val Tyr Lys His Ala Ile 100 105 110 tcc acc atc gta ccg gca cgc tcc gtc aac cta caa cat gaa aac aga 384 Ser Thr Ile Val Pro Ala Arg Ser Val Asn Leu Gln His Glu Asn Arg 115 120 125 ccc caa gcc gca ccg act tcg acc ctc gtc caa gtg gaa acc gtc cag 432 Pro Gln Ala Ala Pro Thr Ser Thr Leu Val Gln Val Glu Thr Val Gln 130 135 140 cag cct gcc gaa 444 Gln Pro Ala Glu 145 <210> 128 <211> 148 <212> PRT <213> Neisseria meningitidis <400> 128 Val Asp Ala Ala Ala Thr Leu Leu Thr Tyr Lys Cys Pro Ala Glu Asn 1 5 10 15 Arg Pro Asn Thr Lys Lys Ile Gly Asn Phe Ser Tyr Ser Arg Leu Gln 20 25 30 Phe Asp Thr His Arg Ala Ser Ala Arg Phe His Asn His Asn Ser Gly 35 40 45 Val Lys Asn Met Thr Ala Lys Gly Gln Met Leu Gln Asp Pro Phe Leu 50 55 60 Asn Ala Leu Arg Lys Glu His Val Pro Val Ser Ile Tyr Leu Val Asn 65 70 75 80 Gly Ile Lys Leu Gln Gly Gln Val Glu Ser Phe Asp Gln Tyr Val Val 85 90 95 Leu Leu Arg Asn Thr Ser Val Thr Gln Met Val Tyr Lys His Ala Ile 100 105 110 Ser Thr Ile Val Pro Ala Arg Ser Val Asn Leu Gln His Glu Asn Arg 115 120 125 Pro Gln Ala Ala Pro Thr Ser Thr Leu Val Gln Val Glu Thr Val Gln 130 135 140 Gln Pro Ala Glu 145 <210> 129 <211> 1308 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1308) <400> 129 atg tac gct aaa aaa ggc ggt ttg gga ctg gtt aaa agc cgc cgt ttc 48 Met Tyr Ala Lys Lys Gly Gly Leu Gly Leu Val Lys Ser Arg Arg Phe 1 5 10 15 gca cct ctt ttc gct acg cag ttt ctc ggc gcg ttc aac gac aat gtg 96 Ala Pro Leu Phe Ala Thr Gln Phe Leu Gly Ala Phe Asn Asp Asn Val 20 25 30 ttc aaa acc gcg ctg ttt gtg atg att ggg ttt tac ggt ttg ggg caa 144 Phe Lys Thr Ala Leu Phe Val Met Ile Gly Phe Tyr Gly Leu Gly Gln 35 40 45 aac ggc ttc ctg cct gcc gga cag atg ttg aac ttg ggc gcg ttg ctg 192 Asn Gly Phe Leu Pro Ala Gly Gln Met Leu Asn Leu Gly Ala Leu Leu 50 55 60 ttt att ttg ccg tat ttc ctg ttt tcc tcg ctg tcg ggg cag ttg ggt 240 Phe Ile Leu Pro Tyr Phe Leu Phe Ser Ser Leu Ser Gly Gln Leu Gly 65 70 75 80 aac aaa ttc gac aag gcc gtt ttg gcg cgt tgg gcc aag gtg ctg gaa 288 Asn Lys Phe Asp Lys Ala Val Leu Ala Arg Trp Ala Lys Val Leu Glu 85 90 95 atg atc att atg gcg gtg gcg gca tac ggg ttt tat atc cgg tct gcc 336 Met Ile Ile Met Ala Val Ala Ala Tyr Gly Phe Tyr Ile Arg Ser Ala 100 105 110 ccg ctg ctt ttg gcg tgt ctg ttt tgc atg ggc gcg caa tcg acg ctg 384 Pro Leu Leu Leu Ala Cys Leu Phe Cys Met Gly Ala Gln Ser Thr Leu 115 120 125 ttc ggg ccg ctg aaa tac gcc atc ctg ccc gat tat ctc gac gac aaa 432 Phe Gly Pro Leu Lys Tyr Ala Ile Leu Pro Asp Tyr Leu Asp Asp Lys 130 135 140 gag ttg atg atg ggc aac agc ctg att gaa tcg ggt acg ttt gtc gcc 480 Glu Leu Met Met Gly Asn Ser Leu Ile Glu Ser Gly Thr Phe Val Ala 145 150 155 160 atc ctg ttc ggt cag ata ctg ggg act gcg gtg gca ggt gta ccg cct 528 Ile Leu Phe Gly Gln Ile Leu Gly Thr Ala Val Ala Gly Val Pro Pro 165 170 175 tat att gtc ggg ata ctg gtt ttg ctg gtc gcc gta gga ggc acg gtc 576 Tyr Ile Val Gly Ile Leu Val Leu Leu Val Ala Val Gly Gly Thr Val 180 185 190 ggc agc ctg ttt atg ccg tcc gta ccc gcc aag gct gcc gat aca caa 624 Gly Ser Leu Phe Met Pro Ser Val Pro Ala Lys Ala Ala Asp Thr Gln 195 200 205 att gag tgg aat att gtc cgg ggt aca aaa tcc ctg ctg cgt gaa acg 672 Ile Glu Trp Asn Ile Val Arg Gly Thr Lys Ser Leu Leu Arg Glu Thr 210 215 220 gtg cgg cac aag ccc gtt ttt acc gcc att atc ggt att tcg tgg ttt 720 Val Arg His Lys Pro Val Phe Thr Ala Ile Ile Gly Ile Ser Trp Phe 225 230 235 240 tgg ttt gtc ggc gcg gtt tat acc acg caa ctg ccg acc ttt acc caa 768 Trp Phe Val Gly Ala Val Tyr Thr Thr Gln Leu Pro Thr Phe Thr Gln 245 250 255 atc cat cta ggc ggc aac gac aat gtt ttc aac ctg atg ctt gcc ctg 816 Ile His Leu Gly Gly Asn Asp Asn Val Phe Asn Leu Met Leu Ala Leu 260 265 270 ttt tcc atc ggt att gcc gcc ggt tcg gta ctg tgt gcc aag ttc agc 864 Phe Ser Ile Gly Ile Ala Ala Gly Ser Val Leu Cys Ala Lys Phe Ser 275 280 285 agg gaa cgg ctg agg ttg gct tgg gta acg gtt ggt gcg ttg ggt ttg 912 Arg Glu Arg Leu Arg Leu Ala Trp Val Thr Val Gly Ala Leu Gly Leu 290 295 300 acg gtt tgc ggc ttg gtt ttg gtg tgg ctg acg cac gga cac cgt ttt 960 Thr Val Cys Gly Leu Val Leu Val Trp Leu Thr His Gly His Arg Phe 305 310 315 320 gaa ggg ctg aac ggc att ttt tgg ttt tta tcg caa gga tgg gca tat 1008 Glu Gly Leu Asn Gly Ile Phe Trp Phe Leu Ser Gln Gly Trp Ala Tyr 325 330 335 ccc gtg atg gcg gtg atg acg ctg atc ggc ttt ttc ggc gga ttt ttc 1056 Pro Val Met Ala Val Met Thr Leu Ile Gly Phe Phe Gly Gly Phe Phe 340 345 350 tcc gtt ccg ctc tat acc tgg ctg caa acc gcc agt agc gag act ttc 1104 Ser Val Pro Leu Tyr Thr Trp Leu Gln Thr Ala Ser Ser Glu Thr Phe 355 360 365 cgc gcc cgc gcc gtt gcc gcc aac aat atc gtt aac ggt att ttt atg 1152 Arg Ala Arg Ala Val Ala Ala Asn Asn Ile Val Asn Gly Ile Phe Met 370 375 380 gtt tcc gct gcc gtt ttg agc gcg gtg ttg ctg ttt ttg ttt gac agc 1200 Val Ser Ala Ala Val Leu Ser Ala Val Leu Leu Phe Leu Phe Asp Ser 385 390 395 400 att tcc ttg ttg tat ctg att gtc gct ttg ggc aat att ccg ttg tcg 1248 Ile Ser Leu Leu Tyr Leu Ile Val Ala Leu Gly Asn Ile Pro Leu Ser 405 410 415 gta ttt ttg att aag cgc gaa agg cgg ttt tta ggc gcg gcg gca atc 1296 Val Phe Leu Ile Lys Arg Glu Arg Arg Phe Leu Gly Ala Ala Ala Ile 420 425 430 agg aaa aaa cct 1308 Arg Lys Lys Pro 435 <210> 130 <211> 436 <212> PRT <213> Neisseria meningitidis <400> 130 Met Tyr Ala Lys Lys Gly Gly Leu Gly Leu Val Lys Ser Arg Arg Phe 1 5 10 15 Ala Pro Leu Phe Ala Thr Gln Phe Leu Gly Ala Phe Asn Asp Asn Val 20 25 30 Phe Lys Thr Ala Leu Phe Val Met Ile Gly Phe Tyr Gly Leu Gly Gln 35 40 45 Asn Gly Phe Leu Pro Ala Gly Gln Met Leu Asn Leu Gly Ala Leu Leu 50 55 60 Phe Ile Leu Pro Tyr Phe Leu Phe Ser Ser Leu Ser Gly Gln Leu Gly 65 70 75 80 Asn Lys Phe Asp Lys Ala Val Leu Ala Arg Trp Ala Lys Val Leu Glu 85 90 95 Met Ile Ile Met Ala Val Ala Ala Tyr Gly Phe Tyr Ile Arg Ser Ala 100 105 110 Pro Leu Leu Leu Ala Cys Leu Phe Cys Met Gly Ala Gln Ser Thr Leu 115 120 125 Phe Gly Pro Leu Lys Tyr Ala Ile Leu Pro Asp Tyr Leu Asp Asp Lys 130 135 140 Glu Leu Met Met Gly Asn Ser Leu Ile Glu Ser Gly Thr Phe Val Ala 145 150 155 160 Ile Leu Phe Gly Gln Ile Leu Gly Thr Ala Val Ala Gly Val Pro Pro 165 170 175 Tyr Ile Val Gly Ile Leu Val Leu Leu Val Ala Val Gly Gly Thr Val 180 185 190 Gly Ser Leu Phe Met Pro Ser Val Pro Ala Lys Ala Ala Asp Thr Gln 195 200 205 Ile Glu Trp Asn Ile Val Arg Gly Thr Lys Ser Leu Leu Arg Glu Thr 210 215 220 Val Arg His Lys Pro Val Phe Thr Ala Ile Ile Gly Ile Ser Trp Phe 225 230 235 240 Trp Phe Val Gly Ala Val Tyr Thr Thr Gln Leu Pro Thr Phe Thr Gln 245 250 255 Ile His Leu Gly Gly Asn Asp Asn Val Phe Asn Leu Met Leu Ala Leu 260 265 270 Phe Ser Ile Gly Ile Ala Ala Gly Ser Val Leu Cys Ala Lys Phe Ser 275 280 285 Arg Glu Arg Leu Arg Leu Ala Trp Val Thr Val Gly Ala Leu Gly Leu 290 295 300 Thr Val Cys Gly Leu Val Leu Val Trp Leu Thr His Gly His Arg Phe 305 310 315 320 Glu Gly Leu Asn Gly Ile Phe Trp Phe Leu Ser Gln Gly Trp Ala Tyr 325 330 335 Pro Val Met Ala Val Met Thr Leu Ile Gly Phe Phe Gly Gly Phe Phe 340 345 350 Ser Val Pro Leu Tyr Thr Trp Leu Gln Thr Ala Ser Ser Glu Thr Phe 355 360 365 Arg Ala Arg Ala Val Ala Ala Asn Asn Ile Val Asn Gly Ile Phe Met 370 375 380 Val Ser Ala Ala Val Leu Ser Ala Val Leu Leu Phe Leu Phe Asp Ser 385 390 395 400 Ile Ser Leu Leu Tyr Leu Ile Val Ala Leu Gly Asn Ile Pro Leu Ser 405 410 415 Val Phe Leu Ile Lys Arg Glu Arg Arg Phe Leu Gly Ala Ala Ala Ile 420 425 430 Arg Lys Lys Pro 435 <210> 131 <211> 876 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(876) <400> 131 atg aat tac gca aaa gaa atc aat gcg tta aat aac agc ctt tcc gat 48 Met Asn Tyr Ala Lys Glu Ile Asn Ala Leu Asn Asn Ser Leu Ser Asp 1 5 10 15 ttg aaa ggc gac atc aac gtt tcg ttt gaa ttt ttt cca ccg aaa aac 96 Leu Lys Gly Asp Ile Asn Val Ser Phe Glu Phe Phe Pro Pro Lys Asn 20 25 30 gag caa atg gaa acg atg ctg tgg gat tcc atc cac cgt ctg caa acc 144 Glu Gln Met Glu Thr Met Leu Trp Asp Ser Ile His Arg Leu Gln Thr 35 40 45 ctg cat ccc aag ttc gta tcc gta acc tac ggc gca aac tcc ggc gaa 192 Leu His Pro Lys Phe Val Ser Val Thr Tyr Gly Ala Asn Ser Gly Glu 50 55 60 cgc gac cgc acg cac ggc atc gtc aaa cgc atc aaa cag gaa acc ggc 240 Arg Asp Arg Thr His Gly Ile Val Lys Arg Ile Lys Gln Glu Thr Gly 65 70 75 80 ttg gaa gca gca ccg cac ctg acc ggc atc gac gca tcc ccc gac gaa 288 Leu Glu Ala Ala Pro His Leu Thr Gly Ile Asp Ala Ser Pro Asp Glu 85 90 95 ttg cgc caa atc gcc aaa gac tat tgg gac agc ggc atc cgc cgc att 336 Leu Arg Gln Ile Ala Lys Asp Tyr Trp Asp Ser Gly Ile Arg Arg Ile 100 105 110 gtc gcc ctg cgt ggc gac gag ccg ccc ggt tat gag aaa aaa ccg ttt 384 Val Ala Leu Arg Gly Asp Glu Pro Pro Gly Tyr Glu Lys Lys Pro Phe 115 120 125 tac gcc gaa gac ttg gtt aag cta tta cgc tcc gtc gcc gac ttc gac 432 Tyr Ala Glu Asp Leu Val Lys Leu Leu Arg Ser Val Ala Asp Phe Asp 130 135 140 atc tct gtg gcg gca tat ccc gaa gtg cat ccc gaa gcc aaa tcc gca 480 Ile Ser Val Ala Ala Tyr Pro Glu Val His Pro Glu Ala Lys Ser Ala 145 150 155 160 caa gcc gat ctg att aat ctg aag cgc aaa atc gat gcg ggt gca aac 528 Gln Ala Asp Leu Ile Asn Leu Lys Arg Lys Ile Asp Ala Gly Ala Asn 165 170 175 cac gtc atc acc caa ttt ttc ttt gac gta gaa cgc tac ctg cgc ttc 576 His Val Ile Thr Gln Phe Phe Phe Asp Val Glu Arg Tyr Leu Arg Phe 180 185 190 cgc gac cgc tgc gtg atg ttg ggt atc gat gtg gaa atc gtc cct ggt 624 Arg Asp Arg Cys Val Met Leu Gly Ile Asp Val Glu Ile Val Pro Gly 195 200 205 att ttg cct gtt acc aac ttc aag cag ctc ggc aaa atg gcg caa gta 672 Ile Leu Pro Val Thr Asn Phe Lys Gln Leu Gly Lys Met Ala Gln Val 210 215 220 acc aac gtc aaa atc cca agc tgg ctg tcg caa atg tat gaa ggt ttg 720 Thr Asn Val Lys Ile Pro Ser Trp Leu Ser Gln Met Tyr Glu Gly Leu 225 230 235 240 gac gac gac caa ggc acg cgc aac ctc gtc gcc gcc agt atc gcc atc 768 Asp Asp Asp Gln Gly Thr Arg Asn Leu Val Ala Ala Ser Ile Ala Ile 245 250 255 gat atg gtc aaa gtc ctg tcc cgc gaa ggc gtg aaa gat ttc cac ttc 816 Asp Met Val Lys Val Leu Ser Arg Glu Gly Val Lys Asp Phe His Phe 260 265 270 tac acg ctc aac cgc agc gag ctg act tac gcc atc tgc cat att tta 864 Tyr Thr Leu Asn Arg Ser Glu Leu Thr Tyr Ala Ile Cys His Ile Leu 275 280 285 ggc gtg cgc cct 876 Gly Val Arg Pro 290 <210> 132 <211> 292 <212> PRT <213> Neisseria meningitidis <400> 132 Met Asn Tyr Ala Lys Glu Ile Asn Ala Leu Asn Asn Ser Leu Ser Asp 1 5 10 15 Leu Lys Gly Asp Ile Asn Val Ser Phe Glu Phe Phe Pro Pro Lys Asn 20 25 30 Glu Gln Met Glu Thr Met Leu Trp Asp Ser Ile His Arg Leu Gln Thr 35 40 45 Leu His Pro Lys Phe Val Ser Val Thr Tyr Gly Ala Asn Ser Gly Glu 50 55 60 Arg Asp Arg Thr His Gly Ile Val Lys Arg Ile Lys Gln Glu Thr Gly 65 70 75 80 Leu Glu Ala Ala Pro His Leu Thr Gly Ile Asp Ala Ser Pro Asp Glu 85 90 95 Leu Arg Gln Ile Ala Lys Asp Tyr Trp Asp Ser Gly Ile Arg Arg Ile 100 105 110 Val Ala Leu Arg Gly Asp Glu Pro Pro Gly Tyr Glu Lys Lys Pro Phe 115 120 125 Tyr Ala Glu Asp Leu Val Lys Leu Leu Arg Ser Val Ala Asp Phe Asp 130 135 140 Ile Ser Val Ala Ala Tyr Pro Glu Val His Pro Glu Ala Lys Ser Ala 145 150 155 160 Gln Ala Asp Leu Ile Asn Leu Lys Arg Lys Ile Asp Ala Gly Ala Asn 165 170 175 His Val Ile Thr Gln Phe Phe Phe Asp Val Glu Arg Tyr Leu Arg Phe 180 185 190 Arg Asp Arg Cys Val Met Leu Gly Ile Asp Val Glu Ile Val Pro Gly 195 200 205 Ile Leu Pro Val Thr Asn Phe Lys Gln Leu Gly Lys Met Ala Gln Val 210 215 220 Thr Asn Val Lys Ile Pro Ser Trp Leu Ser Gln Met Tyr Glu Gly Leu 225 230 235 240 Asp Asp Asp Gln Gly Thr Arg Asn Leu Val Ala Ala Ser Ile Ala Ile 245 250 255 Asp Met Val Lys Val Leu Ser Arg Glu Gly Val Lys Asp Phe His Phe 260 265 270 Tyr Thr Leu Asn Arg Ser Glu Leu Thr Tyr Ala Ile Cys His Ile Leu 275 280 285 Gly Val Arg Pro 290 <210> 133 <211> 1371 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1371) <400> 133 atg agt aat cca ttt tcc tct tta ggt ttg ggt acg gaa ctc gtt tcc 48 Met Ser Asn Pro Phe Ser Ser Leu Gly Leu Gly Thr Glu Leu Val Ser 1 5 10 15 gca ctg acc gcg caa ggt tac gaa aac ccg aca ccc atc caa gcc gcc 96 Ala Leu Thr Ala Gln Gly Tyr Glu Asn Pro Thr Pro Ile Gln Ala Ala 20 25 30 gcc att ccc aaa gca ctc gcc ggt cat gat ttg cta gcc gcc gcg caa 144 Ala Ile Pro Lys Ala Leu Ala Gly His Asp Leu Leu Ala Ala Ala Gln 35 40 45 acc ggc aca ggc aaa acc gcc gcc ttt atg ctg ccc agt ctg gaa cgc 192 Thr Gly Thr Gly Lys Thr Ala Ala Phe Met Leu Pro Ser Leu Glu Arg 50 55 60 ctc aaa cgt tac gcc acc gcc agc acc tcg ccc gcg atg cac ccc gtg 240 Leu Lys Arg Tyr Ala Thr Ala Ser Thr Ser Pro Ala Met His Pro Val 65 70 75 80 cgt atg ctc gtc ctc acc ccc acg cgc gaa ctt gcc gac caa atc gac 288 Arg Met Leu Val Leu Thr Pro Thr Arg Glu Leu Ala Asp Gln Ile Asp 85 90 95 caa aac gtg cag ggc tac atc aaa aac ctg ccg ctg cgc cac acc gtc 336 Gln Asn Val Gln Gly Tyr Ile Lys Asn Leu Pro Leu Arg His Thr Val 100 105 110 ttg ttc ggc ggt atg aat atg gac aaa cag acc gcc gac ctg cgt gcc 384 Leu Phe Gly Gly Met Asn Met Asp Lys Gln Thr Ala Asp Leu Arg Ala 115 120 125 ggc tgc gaa atc gtc gtc gcc acc gtc gga cgg ctg ctc gac cac gtg 432 Gly Cys Glu Ile Val Val Ala Thr Val Gly Arg Leu Leu Asp His Val 130 135 140 aaa cag aaa aac atc cat ttg aac aaa gtc gaa atc gtc gtt ttg gac 480 Lys Gln Lys Asn Ile His Leu Asn Lys Val Glu Ile Val Val Leu Asp 145 150 155 160 gaa gcc gac cgt atg ctg gat atg ggt ttt atc gac gac atc cgc aaa 528 Glu Ala Asp Arg Met Leu Asp Met Gly Phe Ile Asp Asp Ile Arg Lys 165 170 175 atc atg cag atg ctg ccc cgc caa cgc caa acc ctg ctc ttt tcc gcc 576 Ile Met Gln Met Leu Pro Arg Gln Arg Gln Thr Leu Leu Phe Ser Ala 180 185 190 acc ttc tcc gcc ccg ata cgc aaa ctg gcg caa gac ttc atg aac gcg 624 Thr Phe Ser Ala Pro Ile Arg Lys Leu Ala Gln Asp Phe Met Asn Ala 195 200 205 ccc gaa acc gtc gaa gtc gcc gcg caa gac acc acc aac gcc aac gtc 672 Pro Glu Thr Val Glu Val Ala Ala Gln Asp Thr Thr Asn Ala Asn Val 210 215 220 gag cag cac atc atc gcc gtc gat acc att cag aag cgc aac ctg ctc 720 Glu Gln His Ile Ile Ala Val Asp Thr Ile Gln Lys Arg Asn Leu Leu 225 230 235 240 gaa cgg ctg att gtc gat ttg cat atg aac cag gtc atc gtg ttc tgc 768 Glu Arg Leu Ile Val Asp Leu His Met Asn Gln Val Ile Val Phe Cys 245 250 255 aaa acc aaa caa agc gtc gac cgc gta acg cgc gaa ctg gtg cgc cgc 816 Lys Thr Lys Gln Ser Val Asp Arg Val Thr Arg Glu Leu Val Arg Arg 260 265 270 aac ctg tcc gca cag gcg ata cac ggc gac cgt tcc caa caa agc cgg 864 Asn Leu Ser Ala Gln Ala Ile His Gly Asp Arg Ser Gln Gln Ser Arg 275 280 285 ctc gaa aca ctc aac gcc ttc aaa gac ggc aac ctg cgc gtc ctc gtc 912 Leu Glu Thr Leu Asn Ala Phe Lys Asp Gly Asn Leu Arg Val Leu Val 290 295 300 gcc acc gat atc gcc gcg cgg ggg ctg gat att gcc gaa ctg ccc ttc 960 Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Ile Ala Glu Leu Pro Phe 305 310 315 320 gtc atc aat tac gaa atg ccc gcc cag ccc gaa gac tac gtc cac cgc 1008 Val Ile Asn Tyr Glu Met Pro Ala Gln Pro Glu Asp Tyr Val His Arg 325 330 335 atc ggg cgc acg ggg cgc gcg ggc gcg gac ggc gtg gcg att tcc ctg 1056 Ile Gly Arg Thr Gly Arg Ala Gly Ala Asp Gly Val Ala Ile Ser Leu 340 345 350 atg gac gaa tcc gaa cag aaa atg ttt gaa tcc att aaa gag ctg acc 1104 Met Asp Glu Ser Glu Gln Lys Met Phe Glu Ser Ile Lys Glu Leu Thr 355 360 365 ggc aac aag ctg ctc atc gag cgc atc gag ggc ttc gag ccg caa tgg 1152 Gly Asn Lys Leu Leu Ile Glu Arg Ile Glu Gly Phe Glu Pro Gln Trp 370 375 380 tgg gaa cag ggc ggc gca aaa ccg gaa aaa ccc gaa atg cgc gaa cca 1200 Trp Glu Gln Gly Gly Ala Lys Pro Glu Lys Pro Glu Met Arg Glu Pro 385 390 395 400 aga caa cgc aac cgc tac gaa tcc gcc aaa gcg caa cgc gaa aaa aac 1248 Arg Gln Arg Asn Arg Tyr Glu Ser Ala Lys Ala Gln Arg Glu Lys Asn 405 410 415 acc cgg ccg gaa aat gcg gca aac gat gcg ggc gcg gct tgc gga aaa 1296 Thr Arg Pro Glu Asn Ala Ala Asn Asp Ala Gly Ala Ala Cys Gly Lys 420 425 430 att gcc gga cgc agc cgc cga agc cgc cgg gaa cac cgg acg tgc gcc 1344 Ile Ala Gly Arg Ser Arg Arg Ser Arg Arg Glu His Arg Thr Cys Ala 435 440 445 ctg ctc caa ccg cgt tac ggc gta aaa 1371 Leu Leu Gln Pro Arg Tyr Gly Val Lys 450 455 <210> 134 <211> 457 <212> PRT <213> Neisseria meningitidis <400> 134 Met Ser Asn Pro Phe Ser Ser Leu Gly Leu Gly Thr Glu Leu Val Ser 1 5 10 15 Ala Leu Thr Ala Gln Gly Tyr Glu Asn Pro Thr Pro Ile Gln Ala Ala 20 25 30 Ala Ile Pro Lys Ala Leu Ala Gly His Asp Leu Leu Ala Ala Ala Gln 35 40 45 Thr Gly Thr Gly Lys Thr Ala Ala Phe Met Leu Pro Ser Leu Glu Arg 50 55 60 Leu Lys Arg Tyr Ala Thr Ala Ser Thr Ser Pro Ala Met His Pro Val 65 70 75 80 Arg Met Leu Val Leu Thr Pro Thr Arg Glu Leu Ala Asp Gln Ile Asp 85 90 95 Gln Asn Val Gln Gly Tyr Ile Lys Asn Leu Pro Leu Arg His Thr Val 100 105 110 Leu Phe Gly Gly Met Asn Met Asp Lys Gln Thr Ala Asp Leu Arg Ala 115 120 125 Gly Cys Glu Ile Val Val Ala Thr Val Gly Arg Leu Leu Asp His Val 130 135 140 Lys Gln Lys Asn Ile His Leu Asn Lys Val Glu Ile Val Val Leu Asp 145 150 155 160 Glu Ala Asp Arg Met Leu Asp Met Gly Phe Ile Asp Asp Ile Arg Lys 165 170 175 Ile Met Gln Met Leu Pro Arg Gln Arg Gln Thr Leu Leu Phe Ser Ala 180 185 190 Thr Phe Ser Ala Pro Ile Arg Lys Leu Ala Gln Asp Phe Met Asn Ala 195 200 205 Pro Glu Thr Val Glu Val Ala Ala Gln Asp Thr Thr Asn Ala Asn Val 210 215 220 Glu Gln His Ile Ile Ala Val Asp Thr Ile Gln Lys Arg Asn Leu Leu 225 230 235 240 Glu Arg Leu Ile Val Asp Leu His Met Asn Gln Val Ile Val Phe Cys 245 250 255 Lys Thr Lys Gln Ser Val Asp Arg Val Thr Arg Glu Leu Val Arg Arg 260 265 270 Asn Leu Ser Ala Gln Ala Ile His Gly Asp Arg Ser Gln Gln Ser Arg 275 280 285 Leu Glu Thr Leu Asn Ala Phe Lys Asp Gly Asn Leu Arg Val Leu Val 290 295 300 Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Ile Ala Glu Leu Pro Phe 305 310 315 320 Val Ile Asn Tyr Glu Met Pro Ala Gln Pro Glu Asp Tyr Val His Arg 325 330 335 Ile Gly Arg Thr Gly Arg Ala Gly Ala Asp Gly Val Ala Ile Ser Leu 340 345 350 Met Asp Glu Ser Glu Gln Lys Met Phe Glu Ser Ile Lys Glu Leu Thr 355 360 365 Gly Asn Lys Leu Leu Ile Glu Arg Ile Glu Gly Phe Glu Pro Gln Trp 370 375 380 Trp Glu Gln Gly Gly Ala Lys Pro Glu Lys Pro Glu Met Arg Glu Pro 385 390 395 400 Arg Gln Arg Asn Arg Tyr Glu Ser Ala Lys Ala Gln Arg Glu Lys Asn 405 410 415 Thr Arg Pro Glu Asn Ala Ala Asn Asp Ala Gly Ala Ala Cys Gly Lys 420 425 430 Ile Ala Gly Arg Ser Arg Arg Ser Arg Arg Glu His Arg Thr Cys Ala 435 440 445 Leu Leu Gln Pro Arg Tyr Gly Val Lys 450 455 <210> 135 <211> 1374 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1374) <400> 135 atg aaa cac atc cac att atc ggt atc ggc ggc acg ttt atg ggt ggg 48 Met Lys His Ile His Ile Ile Gly Ile Gly Gly Thr Phe Met Gly Gly 1 5 10 15 att gcc gcc att gcc aaa gaa gca ggg ttt gaa gtc agc ggt tgc gat 96 Ile Ala Ala Ile Ala Lys Glu Ala Gly Phe Glu Val Ser Gly Cys Asp 20 25 30 gcg aag atg tat ccg ccg atg agc acc cag ctc gaa gcc ttg ggc ata 144 Ala Lys Met Tyr Pro Pro Met Ser Thr Gln Leu Glu Ala Leu Gly Ile 35 40 45 ggc gtg tat gaa ggc ttc gac acc gcg cag ttg gac gaa ttt aaa gcc 192 Gly Val Tyr Glu Gly Phe Asp Thr Ala Gln Leu Asp Glu Phe Lys Ala 50 55 60 gac gtt tac gtt atc ggc aat gtc gcc aag cgc ggg atg gat gtg gtt 240 Asp Val Tyr Val Ile Gly Asn Val Ala Lys Arg Gly Met Asp Val Val 65 70 75 80 gaa gcg att ttg aac cgt ggg ctg cct tat att tcc ggc ccg caa tgg 288 Glu Ala Ile Leu Asn Arg Gly Leu Pro Tyr Ile Ser Gly Pro Gln Trp 85 90 95 ctg gct gaa aac gtg ctg cac cat cat tgg gta ctc ggc gtg gcg ggg 336 Leu Ala Glu Asn Val Leu His His His Trp Val Leu Gly Val Ala Gly 100 105 110 acg cac ggc aaa acg acc acc gcg tct atg ctc gcg tgg gtt ttg gaa 384 Thr His Gly Lys Thr Thr Thr Ala Ser Met Leu Ala Trp Val Leu Glu 115 120 125 tat gcc gga ctc gca ccg ggc ttc ctt atc ggc ggc gta ccg gaa aac 432 Tyr Ala Gly Leu Ala Pro Gly Phe Leu Ile Gly Gly Val Pro Glu Asn 130 135 140 ttc agc gtt tcc gcc cgc ctg ccg caa acg ccg cgc caa gac ccg aac 480 Phe Ser Val Ser Ala Arg Leu Pro Gln Thr Pro Arg Gln Asp Pro Asn 145 150 155 160 agc caa tcg ccg ttt ttc gtc att gaa gcc gac gaa tac gac acc gcg 528 Ser Gln Ser Pro Phe Phe Val Ile Glu Ala Asp Glu Tyr Asp Thr Ala 165 170 175 ttt ttc gac aaa cgc tcc aaa ttc gtg cat tac cgt ccg cgt acc gcc 576 Phe Phe Asp Lys Arg Ser Lys Phe Val His Tyr Arg Pro Arg Thr Ala 180 185 190 gtg ttg aac aat ctg gaa ttc gac cac gcc gac atc ttc gcc gat ttg 624 Val Leu Asn Asn Leu Glu Phe Asp His Ala Asp Ile Phe Ala Asp Leu 195 200 205 ggc gcg ata cag acc cag ttc cac cac ctc gtg cgt acc gtg ccg tct 672 Gly Ala Ile Gln Thr Gln Phe His His Leu Val Arg Thr Val Pro Ser 210 215 220 gaa ggc ctc atc gtc tgc aac gga cgg cag caa agc ctg caa gac act 720 Glu Gly Leu Ile Val Cys Asn Gly Arg Gln Gln Ser Leu Gln Asp Thr 225 230 235 240 ttg gac aaa ggc tgc tgg acg ccg gtg gaa aaa ttc ggc acg gaa cac 768 Leu Asp Lys Gly Cys Trp Thr Pro Val Glu Lys Phe Gly Thr Glu His 245 250 255 ggc tgg cag gcc ggc gaa gcc aat gcc gat ggc tcg ttc gac gtg ttg 816 Gly Trp Gln Ala Gly Glu Ala Asn Ala Asp Gly Ser Phe Asp Val Leu 260 265 270 ctt gac ggc aaa aaa gcc gga cac gtc gct tgg agt ttg atg ggc gga 864 Leu Asp Gly Lys Lys Ala Gly His Val Ala Trp Ser Leu Met Gly Gly 275 280 285 cac aac cgc atg aac gcg ctc gcc gtc atc gcc gcc gcg cgt cat gcc 912 His Asn Arg Met Asn Ala Leu Ala Val Ile Ala Ala Ala Arg His Ala 290 295 300 gga gtc gac att cag acg gcc tgc gaa gcc ttg agc acg ttt aaa aac 960 Gly Val Asp Ile Gln Thr Ala Cys Glu Ala Leu Ser Thr Phe Lys Asn 305 310 315 320 gtc aaa cgc cgc atg gaa atc aaa ggc acg gca aac ggt atc acc gtt 1008 Val Lys Arg Arg Met Glu Ile Lys Gly Thr Ala Asn Gly Ile Thr Val 325 330 335 tac gac gac ttc gcc cac cat ccg acc gct atc gaa acc acg att caa 1056 Tyr Asp Asp Phe Ala His His Pro Thr Ala Ile Glu Thr Thr Ile Gln 340 345 350 ggt ttg cgc cag cgc gtc ggc ggc gcg cgc atc ctc gcc gtc ctc gaa 1104 Gly Leu Arg Gln Arg Val Gly Gly Ala Arg Ile Leu Ala Val Leu Glu 355 360 365 ccg cgt tcc aat acg atg aag ctg ggt acg atg aaa gcc gcc ctg ccc 1152 Pro Arg Ser Asn Thr Met Lys Leu Gly Thr Met Lys Ala Ala Leu Pro 370 375 380 gca agc ctc aaa gaa gcc gac caa gtg ttc tgc tac gcc ggc ggc gcg 1200 Ala Ser Leu Lys Glu Ala Asp Gln Val Phe Cys Tyr Ala Gly Gly Ala 385 390 395 400 gac tgg gac gtt gcc gaa gcc ctc gcg cct ttg ggc ggc agg ctg cac 1248 Asp Trp Asp Val Ala Glu Ala Leu Ala Pro Leu Gly Gly Arg Leu His 405 410 415 gtc ggc aaa gac ttc gat gcc ttc gtt gcc gaa atc gtg aaa aac gcc 1296 Val Gly Lys Asp Phe Asp Ala Phe Val Ala Glu Ile Val Lys Asn Ala 420 425 430 gaa gca ggc gac cat att ttg gtg atg agc aac ggc ggt ttc ggc gga 1344 Glu Ala Gly Asp His Ile Leu Val Met Ser Asn Gly Gly Phe Gly Gly 435 440 445 ata cac acc aaa ctg ctg gac gct ttg aga 1374 Ile His Thr Lys Leu Leu Asp Ala Leu Arg 450 455 <210> 136 <211> 458 <212> PRT <213> Neisseria meningitidis <400> 136 Met Lys His Ile His Ile Ile Gly Ile Gly Gly Thr Phe Met Gly Gly 1 5 10 15 Ile Ala Ala Ile Ala Lys Glu Ala Gly Phe Glu Val Ser Gly Cys Asp 20 25 30 Ala Lys Met Tyr Pro Pro Met Ser Thr Gln Leu Glu Ala Leu Gly Ile 35 40 45 Gly Val Tyr Glu Gly Phe Asp Thr Ala Gln Leu Asp Glu Phe Lys Ala 50 55 60 Asp Val Tyr Val Ile Gly Asn Val Ala Lys Arg Gly Met Asp Val Val 65 70 75 80 Glu Ala Ile Leu Asn Arg Gly Leu Pro Tyr Ile Ser Gly Pro Gln Trp 85 90 95 Leu Ala Glu Asn Val Leu His His His Trp Val Leu Gly Val Ala Gly 100 105 110 Thr His Gly Lys Thr Thr Thr Ala Ser Met Leu Ala Trp Val Leu Glu 115 120 125 Tyr Ala Gly Leu Ala Pro Gly Phe Leu Ile Gly Gly Val Pro Glu Asn 130 135 140 Phe Ser Val Ser Ala Arg Leu Pro Gln Thr Pro Arg Gln Asp Pro Asn 145 150 155 160 Ser Gln Ser Pro Phe Phe Val Ile Glu Ala Asp Glu Tyr Asp Thr Ala 165 170 175 Phe Phe Asp Lys Arg Ser Lys Phe Val His Tyr Arg Pro Arg Thr Ala 180 185 190 Val Leu Asn Asn Leu Glu Phe Asp His Ala Asp Ile Phe Ala Asp Leu 195 200 205 Gly Ala Ile Gln Thr Gln Phe His His Leu Val Arg Thr Val Pro Ser 210 215 220 Glu Gly Leu Ile Val Cys Asn Gly Arg Gln Gln Ser Leu Gln Asp Thr 225 230 235 240 Leu Asp Lys Gly Cys Trp Thr Pro Val Glu Lys Phe Gly Thr Glu His 245 250 255 Gly Trp Gln Ala Gly Glu Ala Asn Ala Asp Gly Ser Phe Asp Val Leu 260 265 270 Leu Asp Gly Lys Lys Ala Gly His Val Ala Trp Ser Leu Met Gly Gly 275 280 285 His Asn Arg Met Asn Ala Leu Ala Val Ile Ala Ala Ala Arg His Ala 290 295 300 Gly Val Asp Ile Gln Thr Ala Cys Glu Ala Leu Ser Thr Phe Lys Asn 305 310 315 320 Val Lys Arg Arg Met Glu Ile Lys Gly Thr Ala Asn Gly Ile Thr Val 325 330 335 Tyr Asp Asp Phe Ala His His Pro Thr Ala Ile Glu Thr Thr Ile Gln 340 345 350 Gly Leu Arg Gln Arg Val Gly Gly Ala Arg Ile Leu Ala Val Leu Glu 355 360 365 Pro Arg Ser Asn Thr Met Lys Leu Gly Thr Met Lys Ala Ala Leu Pro 370 375 380 Ala Ser Leu Lys Glu Ala Asp Gln Val Phe Cys Tyr Ala Gly Gly Ala 385 390 395 400 Asp Trp Asp Val Ala Glu Ala Leu Ala Pro Leu Gly Gly Arg Leu His 405 410 415 Val Gly Lys Asp Phe Asp Ala Phe Val Ala Glu Ile Val Lys Asn Ala 420 425 430 Glu Ala Gly Asp His Ile Leu Val Met Ser Asn Gly Gly Phe Gly Gly 435 440 445 Ile His Thr Lys Leu Leu Asp Ala Leu Arg 450 455 <210> 137 <211> 876 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(876) <400> 137 ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc 48 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat 96 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac 144 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg 192 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg 240 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa 288 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc 336 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc 384 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg 432 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa 480 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa 528 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat 576 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc 624 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac 672 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc 720 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg 768 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa 816 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc 864 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 cat aaa aaa gac 876 His Lys Lys Asp 290 <210> 138 <211> 292 <212> PRT <213> Neisseria meningitidis <400> 138 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 His Lys Lys Asp 290 <210> 139 <211> 708 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(708) <400> 139 ttg cgg cag ctt gga tgt ttg att ggt ttt ttc agt gtt gga atc att 48 Leu Arg Gln Leu Gly Cys Leu Ile Gly Phe Phe Ser Val Gly Ile Ile 1 5 10 15 atg aat ttg aaa tta gtg ttt gaa tcg ggc gat ccc gtc ctg atc ggt 96 Met Asn Leu Lys Leu Val Phe Glu Ser Gly Asp Pro Val Leu Ile Gly 20 25 30 gtg ttt gtg ttg atg ctg ttg atg agt atc gta acg tgg tgt ttg gtt 144 Val Phe Val Leu Met Leu Leu Met Ser Ile Val Thr Trp Cys Leu Val 35 40 45 gtc ttg cgc tgc atc aag ctg tat cgg gcg cgc aaa ggg aat gcc gcc 192 Val Leu Arg Cys Ile Lys Leu Tyr Arg Ala Arg Lys Gly Asn Ala Ala 50 55 60 gtc aaa cgg cat atg cgc gat act ttg tcg ctg aac gac gcg gtc gaa 240 Val Lys Arg His Met Arg Asp Thr Leu Ser Leu Asn Asp Ala Val Glu 65 70 75 80 aaa gtg cgc gcc gtc gat gcg cct ttg tcc aaa ctg gcg caa gag gca 288 Lys Val Arg Ala Val Asp Ala Pro Leu Ser Lys Leu Ala Gln Glu Ala 85 90 95 ttg cag tct tac cgc aac tac cgc cga aac gaa gcg tcc gaa ctg gcg 336 Leu Gln Ser Tyr Arg Asn Tyr Arg Arg Asn Glu Ala Ser Glu Leu Ala 100 105 110 cag gct ttg ccg ttg aac gag tat ttg gtc att caa atc cgc aac agt 384 Gln Ala Leu Pro Leu Asn Glu Tyr Leu Val Ile Gln Ile Arg Asn Ser 115 120 125 atg gcg cag att atg cgc cgg ttt gat tac ggg atg acc gcg ctt gcc 432 Met Ala Gln Ile Met Arg Arg Phe Asp Tyr Gly Met Thr Ala Leu Ala 130 135 140 tcc atc ggc gcg acc gcg ccg ttt atc ggg ttg ttc ggc acg gtt tgg 480 Ser Ile Gly Ala Thr Ala Pro Phe Ile Gly Leu Phe Gly Thr Val Trp 145 150 155 160 ggg att tac cac gcc ctg atc aat atc ggg caa agc ggg cag atg agt 528 Gly Ile Tyr His Ala Leu Ile Asn Ile Gly Gln Ser Gly Gln Met Ser 165 170 175 att gcg gcg gtt gcc ggc ccg att ggc gag gca ctg gtg gcg acg gcg 576 Ile Ala Ala Val Ala Gly Pro Ile Gly Glu Ala Leu Val Ala Thr Ala 180 185 190 gcg ggt ttg ttc gtg gcg att ccg gcg gtg ttg gca tac aac ttc ctc 624 Ala Gly Leu Phe Val Ala Ile Pro Ala Val Leu Ala Tyr Asn Phe Leu 195 200 205 aat cgc ggc aca aaa ata ctg acc cag gat ttg gat gcg atg gcg cac 672 Asn Arg Gly Thr Lys Ile Leu Thr Gln Asp Leu Asp Ala Met Ala His 210 215 220 gat ttg cac gtc cgc ctg ctt aat caa aag gat agc 708 Asp Leu His Val Arg Leu Leu Asn Gln Lys Asp Ser 225 230 235 <210> 140 <211> 236 <212> PRT <213> Neisseria meningitidis <400> 140 Leu Arg Gln Leu Gly Cys Leu Ile Gly Phe Phe Ser Val Gly Ile Ile 1 5 10 15 Met Asn Leu Lys Leu Val Phe Glu Ser Gly Asp Pro Val Leu Ile Gly 20 25 30 Val Phe Val Leu Met Leu Leu Met Ser Ile Val Thr Trp Cys Leu Val 35 40 45 Val Leu Arg Cys Ile Lys Leu Tyr Arg Ala Arg Lys Gly Asn Ala Ala 50 55 60 Val Lys Arg His Met Arg Asp Thr Leu Ser Leu Asn Asp Ala Val Glu 65 70 75 80 Lys Val Arg Ala Val Asp Ala Pro Leu Ser Lys Leu Ala Gln Glu Ala 85 90 95 Leu Gln Ser Tyr Arg Asn Tyr Arg Arg Asn Glu Ala Ser Glu Leu Ala 100 105 110 Gln Ala Leu Pro Leu Asn Glu Tyr Leu Val Ile Gln Ile Arg Asn Ser 115 120 125 Met Ala Gln Ile Met Arg Arg Phe Asp Tyr Gly Met Thr Ala Leu Ala 130 135 140 Ser Ile Gly Ala Thr Ala Pro Phe Ile Gly Leu Phe Gly Thr Val Trp 145 150 155 160 Gly Ile Tyr His Ala Leu Ile Asn Ile Gly Gln Ser Gly Gln Met Ser 165 170 175 Ile Ala Ala Val Ala Gly Pro Ile Gly Glu Ala Leu Val Ala Thr Ala 180 185 190 Ala Gly Leu Phe Val Ala Ile Pro Ala Val Leu Ala Tyr Asn Phe Leu 195 200 205 Asn Arg Gly Thr Lys Ile Leu Thr Gln Asp Leu Asp Ala Met Ala His 210 215 220 Asp Leu His Val Arg Leu Leu Asn Gln Lys Asp Ser 225 230 235 <210> 141 <211> 812 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(810) <400> 141 atg act atg cac gcc ctc ccc cgc tac gcc gtt ttt ggc aac ccc gtc 48 Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val 1 5 10 15 gcc cac agc aaa tcg ccg caa att cat caa caa ttt gcc ctt cag gaa 96 Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu 20 25 30 ggc gtt gac att gaa tac gaa cgc att tgc gcc gac atc ggc ggt ttc 144 Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe 35 40 45 gcg cag gcg gtt tcg aca ttt ttt gaa aca ggc ggt tgc ggg gca aac 192 Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn 50 55 60 gtt acc gta ccg ttc aag cag gaa gcg ttt cat ctg gcg gac gag cat 240 Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His 65 70 75 80 tct gaa cgc gca ttg gct gcc ggc gcg gtc aac acg ctg att ttt ctg 288 Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu 85 90 95 aaa aac gga aaa ctg cgc ggc gac aat acc gac ggt atc ggt ttg gcc 336 Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala 100 105 110 aac gac atc acg cag gtc aaa aac att gcc atc gaa ggc aaa acc atc 384 Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile 115 120 125 ttg ctt ttg ggc gcg ggc ggc gcg gtg cgc ggc gtg att cct gtt ttg 432 Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu 130 135 140 aaa gaa cac cgt cct gcc cgt atc gtc att gcc aac cgt acc cgc gcc 480 Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala 145 150 155 160 aaa gcc gag gaa ttg gcg cag ctt ttc ggc att gaa gcc gtc ccg atg 528 Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met 165 170 175 gcg gat gtg aac ggc ggt ttt gat atc atc atc aac ggc acg tcg ggc 576 Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly 180 185 190 ggt cta aac ggt cag att ccc gat att ccg ccc gat att ttt caa aac 624 Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn 195 200 205 tgc gcg ctt gcc tac gat atg gtg tac ggc tgc gcg gca aaa ccg ttt 672 Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe 210 215 220 tta gat ttt gca cga caa tcg ggt gcg aaa aaa act gcc gac gga ctg 720 Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu 225 230 235 240 ggt atg cta gtc ggt caa gcg gcg gct tcc tac gcc ctc tgg cgc gga 768 Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly 245 250 255 ttt acg ccc gat atc cgc ccc gtt atc gaa tac atg aaa gcc ct 812 Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala 260 265 270 <210> 142 <211> 270 <212> PRT <213> Neisseria meningitidis <400> 142 Met Thr Met His Ala Leu Pro Arg Tyr Ala Val Phe Gly Asn Pro Val 1 5 10 15 Ala His Ser Lys Ser Pro Gln Ile His Gln Gln Phe Ala Leu Gln Glu 20 25 30 Gly Val Asp Ile Glu Tyr Glu Arg Ile Cys Ala Asp Ile Gly Gly Phe 35 40 45 Ala Gln Ala Val Ser Thr Phe Phe Glu Thr Gly Gly Cys Gly Ala Asn 50 55 60 Val Thr Val Pro Phe Lys Gln Glu Ala Phe His Leu Ala Asp Glu His 65 70 75 80 Ser Glu Arg Ala Leu Ala Ala Gly Ala Val Asn Thr Leu Ile Phe Leu 85 90 95 Lys Asn Gly Lys Leu Arg Gly Asp Asn Thr Asp Gly Ile Gly Leu Ala 100 105 110 Asn Asp Ile Thr Gln Val Lys Asn Ile Ala Ile Glu Gly Lys Thr Ile 115 120 125 Leu Leu Leu Gly Ala Gly Gly Ala Val Arg Gly Val Ile Pro Val Leu 130 135 140 Lys Glu His Arg Pro Ala Arg Ile Val Ile Ala Asn Arg Thr Arg Ala 145 150 155 160 Lys Ala Glu Glu Leu Ala Gln Leu Phe Gly Ile Glu Ala Val Pro Met 165 170 175 Ala Asp Val Asn Gly Gly Phe Asp Ile Ile Ile Asn Gly Thr Ser Gly 180 185 190 Gly Leu Asn Gly Gln Ile Pro Asp Ile Pro Pro Asp Ile Phe Gln Asn 195 200 205 Cys Ala Leu Ala Tyr Asp Met Val Tyr Gly Cys Ala Ala Lys Pro Phe 210 215 220 Leu Asp Phe Ala Arg Gln Ser Gly Ala Lys Lys Thr Ala Asp Gly Leu 225 230 235 240 Gly Met Leu Val Gly Gln Ala Ala Ala Ser Tyr Ala Leu Trp Arg Gly 245 250 255 Phe Thr Pro Asp Ile Arg Pro Val Ile Glu Tyr Met Lys Ala 260 265 270 <210> 143 <211> 1515 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1515) <400> 143 atg ttg tat ttc aga tac ggt ttt ttg gtt gtt tgg tgt gcg gca ggt 48 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 gtt tct gcc gcc tat ggg gcg gat gcg ccc gcg att ttg gat gac aag 96 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 gca ttg ttg cag gtg cag cgg tcg gtg tcg gat aag tgg gcg gaa tcg 144 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 gat tgg aaa gtt gac aat gat gcc ccg cgc gtg gtt gac ggg gat ttt 192 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 ttg ttg gcg cat ccg aaa atg ttg gaa cat agt ttg cgc gac gtg ctc 240 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 aac ggc aat cag gcg gat ttg atc gct tcg ttg gcg gat ttg tat gcc 288 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 aag ctg ccg gat tat gac gcg gtt ttg tac ggc agg gcg cgg gct ttg 336 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 ctg gcg aaa ttg gcg gga agg ccg gcg gag gcg gtg gcg cgg tat cgg 384 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 gaa ctg cac ggg gaa aat gcg gca gac gag cgg att ttg ctg gat ttg 432 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 gcg gcg gcg gag ttt gac gat ttc cgg ctg aag tcg gca gaa agg cat 480 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 ttt gcc gag gcg gaa aaa ttg gat ttg ccg gcg ccg gtt ttg gaa aat 528 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 gtg ggg cgt ttt cgg aaa aaa gcg gag ggg ctg acg ggc tgg cgt ttt 576 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 tcg ggc ggc atc agt ccg gcg gtc aat aga aat gcc aat aat gcc gcg 624 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 ccg cag tat tgc cgg caa aac gga ggc cgg cag ata tgc agt gtc agc 672 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 cgg gcg gag cgg gcg gca ggc ttg aat tat gaa atc gag gcg gaa aaa 720 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 ctg acg gcg ttg gca gat aat cat tat ttg ttg ttc cgt tcc aat atc 768 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 ggc ggc acg agc tat tat ttc agt aaa aaa tca gct tat gac gac ggg 816 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 ttc ggc aga gcg tat ttg ggt tgg cag tat aaa aat gca cgg cag acg 864 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 gcg ggg att ttg ccg ttt tat cag gtg cag ttg tcg ggc agc gac ggc 912 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 ttt gat gcg aaa aca aaa cgg gta aac aac cgc cgc ctg ccg ccg tat 960 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 atg ctg gcg cac gga gtc ggc gtg cag ttg tcc cat act tac cgc cca 1008 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 aac ccg gga tgg caa ttt tcg gtc gcg ctg gaa cat tac cgc caa cgc 1056 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 tac cgc gaa cag gat agg gcg gaa tac aat aac ggt cgg cag gac ggg 1104 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 ttt tat gtt tcg tcg gca aaa cgt ttg ggc gaa tcg gca act gtg ttc 1152 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 ggc ggc tgg cag ttt gtg cgg ttt gtg ccg aaa cgc gaa acg gtg ggc 1200 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 ggc gcg gtc aat aat gcc gcc tac cgg cgc aac ggt gtt tat gcc ggc 1248 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 tgg gcg cag gag tgg cgg cag ttg ggc ggt ttg aac agt cgg gtt tcc 1296 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 gcg tct tat gcc cgc cgc aac tat aag ggc gtt gcg gct ttc tcg aca 1344 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 gag gcg caa cgc aac cgc gaa tgg aat gtc tcg ctg gct ttg agc cac 1392 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 gac aag ttg tcg tac aaa ggt atc gtg ccc gcg ttg aat tat cgt ttc 1440 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 ggc agg acg gaa agt aat gtg ccg tat gcg aaa cgc cgc aac agc gag 1488 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 gtg ttt gtg tcg gcg gat tgg cgg ttt 1515 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 144 <211> 505 <212> PRT <213> Neisseria meningitidis <400> 144 Met Leu Tyr Phe Arg Tyr Gly Phe Leu Val Val Trp Cys Ala Ala Gly 1 5 10 15 Val Ser Ala Ala Tyr Gly Ala Asp Ala Pro Ala Ile Leu Asp Asp Lys 20 25 30 Ala Leu Leu Gln Val Gln Arg Ser Val Ser Asp Lys Trp Ala Glu Ser 35 40 45 Asp Trp Lys Val Asp Asn Asp Ala Pro Arg Val Val Asp Gly Asp Phe 50 55 60 Leu Leu Ala His Pro Lys Met Leu Glu His Ser Leu Arg Asp Val Leu 65 70 75 80 Asn Gly Asn Gln Ala Asp Leu Ile Ala Ser Leu Ala Asp Leu Tyr Ala 85 90 95 Lys Leu Pro Asp Tyr Asp Ala Val Leu Tyr Gly Arg Ala Arg Ala Leu 100 105 110 Leu Ala Lys Leu Ala Gly Arg Pro Ala Glu Ala Val Ala Arg Tyr Arg 115 120 125 Glu Leu His Gly Glu Asn Ala Ala Asp Glu Arg Ile Leu Leu Asp Leu 130 135 140 Ala Ala Ala Glu Phe Asp Asp Phe Arg Leu Lys Ser Ala Glu Arg His 145 150 155 160 Phe Ala Glu Ala Glu Lys Leu Asp Leu Pro Ala Pro Val Leu Glu Asn 165 170 175 Val Gly Arg Phe Arg Lys Lys Ala Glu Gly Leu Thr Gly Trp Arg Phe 180 185 190 Ser Gly Gly Ile Ser Pro Ala Val Asn Arg Asn Ala Asn Asn Ala Ala 195 200 205 Pro Gln Tyr Cys Arg Gln Asn Gly Gly Arg Gln Ile Cys Ser Val Ser 210 215 220 Arg Ala Glu Arg Ala Ala Gly Leu Asn Tyr Glu Ile Glu Ala Glu Lys 225 230 235 240 Leu Thr Ala Leu Ala Asp Asn His Tyr Leu Leu Phe Arg Ser Asn Ile 245 250 255 Gly Gly Thr Ser Tyr Tyr Phe Ser Lys Lys Ser Ala Tyr Asp Asp Gly 260 265 270 Phe Gly Arg Ala Tyr Leu Gly Trp Gln Tyr Lys Asn Ala Arg Gln Thr 275 280 285 Ala Gly Ile Leu Pro Phe Tyr Gln Val Gln Leu Ser Gly Ser Asp Gly 290 295 300 Phe Asp Ala Lys Thr Lys Arg Val Asn Asn Arg Arg Leu Pro Pro Tyr 305 310 315 320 Met Leu Ala His Gly Val Gly Val Gln Leu Ser His Thr Tyr Arg Pro 325 330 335 Asn Pro Gly Trp Gln Phe Ser Val Ala Leu Glu His Tyr Arg Gln Arg 340 345 350 Tyr Arg Glu Gln Asp Arg Ala Glu Tyr Asn Asn Gly Arg Gln Asp Gly 355 360 365 Phe Tyr Val Ser Ser Ala Lys Arg Leu Gly Glu Ser Ala Thr Val Phe 370 375 380 Gly Gly Trp Gln Phe Val Arg Phe Val Pro Lys Arg Glu Thr Val Gly 385 390 395 400 Gly Ala Val Asn Asn Ala Ala Tyr Arg Arg Asn Gly Val Tyr Ala Gly 405 410 415 Trp Ala Gln Glu Trp Arg Gln Leu Gly Gly Leu Asn Ser Arg Val Ser 420 425 430 Ala Ser Tyr Ala Arg Arg Asn Tyr Lys Gly Val Ala Ala Phe Ser Thr 435 440 445 Glu Ala Gln Arg Asn Arg Glu Trp Asn Val Ser Leu Ala Leu Ser His 450 455 460 Asp Lys Leu Ser Tyr Lys Gly Ile Val Pro Ala Leu Asn Tyr Arg Phe 465 470 475 480 Gly Arg Thr Glu Ser Asn Val Pro Tyr Ala Lys Arg Arg Asn Ser Glu 485 490 495 Val Phe Val Ser Ala Asp Trp Arg Phe 500 505 <210> 145 <211> 840 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(840) <400> 145 atg gat aaa gaa cga att tta acc ccc gca gtc gtg ttt tcc gtc gca 48 Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala 1 5 10 15 ctg ctg cat ttg gca atg gtg gca ttg ctc tgg cag gcg cac aag ctg 96 Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu 20 25 30 ccc gtg ata gag tca ggc aat gtt att gaa ttt gtc gat ttg ggc gat 144 Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp 35 40 45 ttt ggc gga ggg gac ggc gca ccc gaa ggt gca ggc gcg cct gcc gcg 192 Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala 50 55 60 ccc gaa ccg caa ccc gtg ccc gag ccg ccc aaa cct gtc gag ccg ccc 240 Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro 65 70 75 80 aag ccg gtt ttg aag ccg gtg gtt acg aaa aag gcg gat gcg gat att 288 Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile 85 90 95 cag cag cct aag gaa gag ccg aaa cct gaa gaa aag ccg aaa ccc gaa 336 Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu 100 105 110 gaa aaa ccg aaa cca gag cct aag ccg gaa gcg aag cct gtc ccg aaa 384 Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys 115 120 125 ccg gcg gaa aaa ccg gtc gag aag ccg tct gaa aaa cct gcc gaa cat 432 Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His 130 135 140 ccc ggc aat gct tct gcc aaa gca gac agc gag cag ggc aat ggg gaa 480 Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu 145 150 155 160 gat aag gga acc ggt atc aaa gga gac gga acg ggg cgc gga gaa ggc 528 Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly 165 170 175 agc ggt aaa ggt agc ggc ggt gtc aaa ggc gaa cac ggg gaa gga gcc 576 Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala 180 185 190 ggc agc agc aaa ggc aat cct tta cgc gcc aac ggc agc att ccg cgc 624 Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg 195 200 205 ccg gct tat ccc acg ctt tct atg gag aat gat gag cag ggt acg gtt 672 Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val 210 215 220 gtt ttg agc gtt ttg gtt tct ccg ggc ggt cat gtt gag tcc gtt aaa 720 Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys 225 230 235 240 atc gtg aaa agc agt ggt ttt tcc cgg ttg gac aat gcg gca cgc aag 768 Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys 245 250 255 gcg gcg caa aac ggg cat ttt caa gcc aat gcc tgg acg gag ttt aaa 816 Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys 260 265 270 gtc ccc gtc aag ttt gaa ttg aat 840 Val Pro Val Lys Phe Glu Leu Asn 275 280 <210> 146 <211> 280 <212> PRT <213> Neisseria meningitidis <400> 146 Met Asp Lys Glu Arg Ile Leu Thr Pro Ala Val Val Phe Ser Val Ala 1 5 10 15 Leu Leu His Leu Ala Met Val Ala Leu Leu Trp Gln Ala His Lys Leu 20 25 30 Pro Val Ile Glu Ser Gly Asn Val Ile Glu Phe Val Asp Leu Gly Asp 35 40 45 Phe Gly Gly Gly Asp Gly Ala Pro Glu Gly Ala Gly Ala Pro Ala Ala 50 55 60 Pro Glu Pro Gln Pro Val Pro Glu Pro Pro Lys Pro Val Glu Pro Pro 65 70 75 80 Lys Pro Val Leu Lys Pro Val Val Thr Lys Lys Ala Asp Ala Asp Ile 85 90 95 Gln Gln Pro Lys Glu Glu Pro Lys Pro Glu Glu Lys Pro Lys Pro Glu 100 105 110 Glu Lys Pro Lys Pro Glu Pro Lys Pro Glu Ala Lys Pro Val Pro Lys 115 120 125 Pro Ala Glu Lys Pro Val Glu Lys Pro Ser Glu Lys Pro Ala Glu His 130 135 140 Pro Gly Asn Ala Ser Ala Lys Ala Asp Ser Glu Gln Gly Asn Gly Glu 145 150 155 160 Asp Lys Gly Thr Gly Ile Lys Gly Asp Gly Thr Gly Arg Gly Glu Gly 165 170 175 Ser Gly Lys Gly Ser Gly Gly Val Lys Gly Glu His Gly Glu Gly Ala 180 185 190 Gly Ser Ser Lys Gly Asn Pro Leu Arg Ala Asn Gly Ser Ile Pro Arg 195 200 205 Pro Ala Tyr Pro Thr Leu Ser Met Glu Asn Asp Glu Gln Gly Thr Val 210 215 220 Val Leu Ser Val Leu Val Ser Pro Gly Gly His Val Glu Ser Val Lys 225 230 235 240 Ile Val Lys Ser Ser Gly Phe Ser Arg Leu Asp Asn Ala Ala Arg Lys 245 250 255 Ala Ala Gln Asn Gly His Phe Gln Ala Asn Ala Trp Thr Glu Phe Lys 260 265 270 Val Pro Val Lys Phe Glu Leu Asn 275 280 <210> 147 <211> 1572 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1572) <400> 147 atg ttc aga cgg tat ctt ccg aac aga cag atg aat atg gtt tcc aaa 48 Met Phe Arg Arg Tyr Leu Pro Asn Arg Gln Met Asn Met Val Ser Lys 1 5 10 15 ctg gac aaa tac tgg cag cac ccc gcc ctc tac tgg cct ttg ctc atc 96 Leu Asp Lys Tyr Trp Gln His Pro Ala Leu Tyr Trp Pro Leu Leu Ile 20 25 30 ctt ttt gcc gcc gcc acc ccc ttt acc ttc gca ccc tac tac cac ttt 144 Leu Phe Ala Ala Ala Thr Pro Phe Thr Phe Ala Pro Tyr Tyr His Phe 35 40 45 tgg ctg atg ccc ttg att ttc ggt gcc ttc gtc cgc ctc atc gaa ctg 192 Trp Leu Met Pro Leu Ile Phe Gly Ala Phe Val Arg Leu Ile Glu Leu 50 55 60 cgt ccg cgt ttt gct gtc tct tcc gcc tac ctg ttc ggc ctg acc gca 240 Arg Pro Arg Phe Ala Val Ser Ser Ala Tyr Leu Phe Gly Leu Thr Ala 65 70 75 80 tac acg aca cag ttc tac tgg ata cac acc gcc ctg cac gac gtt tcc 288 Tyr Thr Thr Gln Phe Tyr Trp Ile His Thr Ala Leu His Asp Val Ser 85 90 95 ggc ctg ccc gac ctc tat gcc gta ccg ctg acc ttc cta ctc ccc gcc 336 Gly Leu Pro Asp Leu Tyr Ala Val Pro Leu Thr Phe Leu Leu Pro Ala 100 105 110 tac ctt gcc ctt tat ccg gca ctg tgt ttc tgg ctg tgg aaa aaa ttt 384 Tyr Leu Ala Leu Tyr Pro Ala Leu Cys Phe Trp Leu Trp Lys Lys Phe 115 120 125 acc ctg cct cgg ggc ata aaa atc ggt ttg gta ctg ccc atc ctg tgg 432 Thr Leu Pro Arg Gly Ile Lys Ile Gly Leu Val Leu Pro Ile Leu Trp 130 135 140 aca ctg acc gag ttt gcc cgc gaa cgt ttc ctg acc gga ttc ggc tgg 480 Thr Leu Thr Glu Phe Ala Arg Glu Arg Phe Leu Thr Gly Phe Gly Trp 145 150 155 160 ggc gca atc ggc tac tcc caa atc acc ccg gac agc ccg ctc gcc ggc 528 Gly Ala Ile Gly Tyr Ser Gln Ile Thr Pro Asp Ser Pro Leu Ala Gly 165 170 175 ttt gcc cca ttt ggc ggc atc cac atg gtt aca ctg gca acc gcc ttt 576 Phe Ala Pro Phe Gly Gly Ile His Met Val Thr Leu Ala Thr Ala Phe 180 185 190 ctc ggt gtc tgg ctg gtt ttg gcg agt gat aac acc gca cgt tcg ggc 624 Leu Gly Val Trp Leu Val Leu Ala Ser Asp Asn Thr Ala Arg Ser Gly 195 200 205 aaa cgc ctg ctt cca att atc ctg att gcc gcc ctg ctt gcc gca ggc 672 Lys Arg Leu Leu Pro Ile Ile Leu Ile Ala Ala Leu Leu Ala Ala Gly 210 215 220 tac acc gcc cga caa acc gac ttc acc cgc ccc gac ggc agc cgc agc 720 Tyr Thr Ala Arg Gln Thr Asp Phe Thr Arg Pro Asp Gly Ser Arg Ser 225 230 235 240 acc gtc gcc ctg ctt caa ggc aac atc gac caa acc ctc aaa tgg cgt 768 Thr Val Ala Leu Leu Gln Gly Asn Ile Asp Gln Thr Leu Lys Trp Arg 245 250 255 gaa gac caa gtc atc ccg acc ata cag aaa tat tac gaa cag gtc ggc 816 Glu Asp Gln Val Ile Pro Thr Ile Gln Lys Tyr Tyr Glu Gln Val Gly 260 265 270 aaa acc act gcc gac atc gtc atc ctg ccc gaa acc gcc atc ccc gtc 864 Lys Thr Thr Ala Asp Ile Val Ile Leu Pro Glu Thr Ala Ile Pro Val 275 280 285 atg cgc caa aac ctg ccg gaa aac ata ctg gca aaa ttt gcc gaa cag 912 Met Arg Gln Asn Leu Pro Glu Asn Ile Leu Ala Lys Phe Ala Glu Gln 290 295 300 gcg caa aac aac ggc agc gcg ctc gcc gtc ggc atc agc caa tac act 960 Ala Gln Asn Asn Gly Ser Ala Leu Ala Val Gly Ile Ser Gln Tyr Thr 305 310 315 320 tcg gac ggc aac ggt tac gaa aac gcc gtc atc aac ctg acc ggt tat 1008 Ser Asp Gly Asn Gly Tyr Glu Asn Ala Val Ile Asn Leu Thr Gly Tyr 325 330 335 cag gaa aac aat cag gac ggc atc ccc tac tac gcc aaa aac cac ctc 1056 Gln Glu Asn Asn Gln Asp Gly Ile Pro Tyr Tyr Ala Lys Asn His Leu 340 345 350 gtc ccc ttc ggc gaa tac aaa ccg ctg ccc ttc ctg acc acg ccg ctt 1104 Val Pro Phe Gly Glu Tyr Lys Pro Leu Pro Phe Leu Thr Thr Pro Leu 355 360 365 tac aaa atg atg aat atg ccc ctt tcc gac ttc cgc aaa ggc ggc ggt 1152 Tyr Lys Met Met Asn Met Pro Leu Ser Asp Phe Arg Lys Gly Gly Gly 370 375 380 aag caa tcc gcc ctg ctg atg aaa aac caa aaa atc gcc ttc aac atc 1200 Lys Gln Ser Ala Leu Leu Met Lys Asn Gln Lys Ile Ala Phe Asn Ile 385 390 395 400 tgt tac gaa gac gga ttc ggc gac gaa ctg att gcc gcc gcc aaa gat 1248 Cys Tyr Glu Asp Gly Phe Gly Asp Glu Leu Ile Ala Ala Ala Lys Asp 405 410 415 gcc aca ctg ctt gcc aat gcc agc aat atg gcg tgg tac gga aaa tcc 1296 Ala Thr Leu Leu Ala Asn Ala Ser Asn Met Ala Trp Tyr Gly Lys Ser 420 425 430 aac gcc atg tac cag cac ctc caa caa tcg cag gcg cgg gct atg gaa 1344 Asn Ala Met Tyr Gln His Leu Gln Gln Ser Gln Ala Arg Ala Met Glu 435 440 445 ctc gga cgc tat atg gtc cgt gcc acc aac acc ggc gca acc gcc atc 1392 Leu Gly Arg Tyr Met Val Arg Ala Thr Asn Thr Gly Ala Thr Ala Ile 450 455 460 atc tcc ccc aaa ggc aac atc atc gcc caa gcc caa ccc gat acg gaa 1440 Ile Ser Pro Lys Gly Asn Ile Ile Ala Gln Ala Gln Pro Asp Thr Glu 465 470 475 480 acc gta ttg gaa gga cac atc aaa ggc tat gtc ggc gaa acg ccc tat 1488 Thr Val Leu Glu Gly His Ile Lys Gly Tyr Val Gly Glu Thr Pro Tyr 485 490 495 atg aaa acc ggc agt tca tgg tgg ttg atg ggc ata ttg acc cta gcc 1536 Met Lys Thr Gly Ser Ser Trp Trp Leu Met Gly Ile Leu Thr Leu Ala 500 505 510 gca ctg att ctt ttc atc ttc cga aac aaa gaa cac 1572 Ala Leu Ile Leu Phe Ile Phe Arg Asn Lys Glu His 515 520 <210> 148 <211> 524 <212> PRT <213> Neisseria meningitidis <400> 148 Met Phe Arg Arg Tyr Leu Pro Asn Arg Gln Met Asn Met Val Ser Lys 1 5 10 15 Leu Asp Lys Tyr Trp Gln His Pro Ala Leu Tyr Trp Pro Leu Leu Ile 20 25 30 Leu Phe Ala Ala Ala Thr Pro Phe Thr Phe Ala Pro Tyr Tyr His Phe 35 40 45 Trp Leu Met Pro Leu Ile Phe Gly Ala Phe Val Arg Leu Ile Glu Leu 50 55 60 Arg Pro Arg Phe Ala Val Ser Ser Ala Tyr Leu Phe Gly Leu Thr Ala 65 70 75 80 Tyr Thr Thr Gln Phe Tyr Trp Ile His Thr Ala Leu His Asp Val Ser 85 90 95 Gly Leu Pro Asp Leu Tyr Ala Val Pro Leu Thr Phe Leu Leu Pro Ala 100 105 110 Tyr Leu Ala Leu Tyr Pro Ala Leu Cys Phe Trp Leu Trp Lys Lys Phe 115 120 125 Thr Leu Pro Arg Gly Ile Lys Ile Gly Leu Val Leu Pro Ile Leu Trp 130 135 140 Thr Leu Thr Glu Phe Ala Arg Glu Arg Phe Leu Thr Gly Phe Gly Trp 145 150 155 160 Gly Ala Ile Gly Tyr Ser Gln Ile Thr Pro Asp Ser Pro Leu Ala Gly 165 170 175 Phe Ala Pro Phe Gly Gly Ile His Met Val Thr Leu Ala Thr Ala Phe 180 185 190 Leu Gly Val Trp Leu Val Leu Ala Ser Asp Asn Thr Ala Arg Ser Gly 195 200 205 Lys Arg Leu Leu Pro Ile Ile Leu Ile Ala Ala Leu Leu Ala Ala Gly 210 215 220 Tyr Thr Ala Arg Gln Thr Asp Phe Thr Arg Pro Asp Gly Ser Arg Ser 225 230 235 240 Thr Val Ala Leu Leu Gln Gly Asn Ile Asp Gln Thr Leu Lys Trp Arg 245 250 255 Glu Asp Gln Val Ile Pro Thr Ile Gln Lys Tyr Tyr Glu Gln Val Gly 260 265 270 Lys Thr Thr Ala Asp Ile Val Ile Leu Pro Glu Thr Ala Ile Pro Val 275 280 285 Met Arg Gln Asn Leu Pro Glu Asn Ile Leu Ala Lys Phe Ala Glu Gln 290 295 300 Ala Gln Asn Asn Gly Ser Ala Leu Ala Val Gly Ile Ser Gln Tyr Thr 305 310 315 320 Ser Asp Gly Asn Gly Tyr Glu Asn Ala Val Ile Asn Leu Thr Gly Tyr 325 330 335 Gln Glu Asn Asn Gln Asp Gly Ile Pro Tyr Tyr Ala Lys Asn His Leu 340 345 350 Val Pro Phe Gly Glu Tyr Lys Pro Leu Pro Phe Leu Thr Thr Pro Leu 355 360 365 Tyr Lys Met Met Asn Met Pro Leu Ser Asp Phe Arg Lys Gly Gly Gly 370 375 380 Lys Gln Ser Ala Leu Leu Met Lys Asn Gln Lys Ile Ala Phe Asn Ile 385 390 395 400 Cys Tyr Glu Asp Gly Phe Gly Asp Glu Leu Ile Ala Ala Ala Lys Asp 405 410 415 Ala Thr Leu Leu Ala Asn Ala Ser Asn Met Ala Trp Tyr Gly Lys Ser 420 425 430 Asn Ala Met Tyr Gln His Leu Gln Gln Ser Gln Ala Arg Ala Met Glu 435 440 445 Leu Gly Arg Tyr Met Val Arg Ala Thr Asn Thr Gly Ala Thr Ala Ile 450 455 460 Ile Ser Pro Lys Gly Asn Ile Ile Ala Gln Ala Gln Pro Asp Thr Glu 465 470 475 480 Thr Val Leu Glu Gly His Ile Lys Gly Tyr Val Gly Glu Thr Pro Tyr 485 490 495 Met Lys Thr Gly Ser Ser Trp Trp Leu Met Gly Ile Leu Thr Leu Ala 500 505 510 Ala Leu Ile Leu Phe Ile Phe Arg Asn Lys Glu His 515 520 <210> 149 <211> 558 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(558) <400> 149 ttg gat ctc tac aaa ctc ggt tac aaa caa cat acc cgt acc gat gcg 48 Leu Asp Leu Tyr Lys Leu Gly Tyr Lys Gln His Thr Arg Thr Asp Ala 1 5 10 15 gaa ggc tat atc gag aaa ctg cac att acc ccc gcc aat gcc cat gag 96 Glu Gly Tyr Ile Glu Lys Leu His Ile Thr Pro Ala Asn Ala His Glu 20 25 30 tgc aaa cac ctg ccg ccg ttg ttg gaa gga ctg ccc aaa ggt acg acc 144 Cys Lys His Leu Pro Pro Leu Leu Glu Gly Leu Pro Lys Gly Thr Thr 35 40 45 gtc tat gcc gac aaa ggc tac gac agt gcg gaa aac cgg caa cat ctg 192 Val Tyr Ala Asp Lys Gly Tyr Asp Ser Ala Glu Asn Arg Gln His Leu 50 55 60 gaa gaa cat cag ttg ttg gac ggc att atg cgc aaa gcc tgc cgc aac 240 Glu Glu His Gln Leu Leu Asp Gly Ile Met Arg Lys Ala Cys Arg Asn 65 70 75 80 cgt ccg ctg tcg gaa acg caa acc aaa cgc aac cgg tat ttg tcg aag 288 Arg Pro Leu Ser Glu Thr Gln Thr Lys Arg Asn Arg Tyr Leu Ser Lys 85 90 95 acc cgt tat agt gga tta aat tta aat cag gac aag gcg acg aag ccg 336 Thr Arg Tyr Ser Gly Leu Asn Leu Asn Gln Asp Lys Ala Thr Lys Pro 100 105 110 cag aca gta caa ata gta cgg caa ggc gag gca acg ccg tac tgg ttt 384 Gln Thr Val Gln Ile Val Arg Gln Gly Glu Ala Thr Pro Tyr Trp Phe 115 120 125 aaa ttt aat cca cta tat gtg gtc gaa cag agc ttc ggt acg ctg cac 432 Lys Phe Asn Pro Leu Tyr Val Val Glu Gln Ser Phe Gly Thr Leu His 130 135 140 cgt aaa ttc cgc tat gcg cgg gca gcc tat ttc gga ctg att aaa gtg 480 Arg Lys Phe Arg Tyr Ala Arg Ala Ala Tyr Phe Gly Leu Ile Lys Val 145 150 155 160 agt gcg caa agc cat ctg aag gcg atg tgt ttg aac ctg ttg aaa gcc 528 Ser Ala Gln Ser His Leu Lys Ala Met Cys Leu Asn Leu Leu Lys Ala 165 170 175 gcc aac aag cta agt gcg ccc gct gcc gcc 558 Ala Asn Lys Leu Ser Ala Pro Ala Ala Ala 180 185 <210> 150 <211> 186 <212> PRT <213> Neisseria meningitidis <400> 150 Leu Asp Leu Tyr Lys Leu Gly Tyr Lys Gln His Thr Arg Thr Asp Ala 1 5 10 15 Glu Gly Tyr Ile Glu Lys Leu His Ile Thr Pro Ala Asn Ala His Glu 20 25 30 Cys Lys His Leu Pro Pro Leu Leu Glu Gly Leu Pro Lys Gly Thr Thr 35 40 45 Val Tyr Ala Asp Lys Gly Tyr Asp Ser Ala Glu Asn Arg Gln His Leu 50 55 60 Glu Glu His Gln Leu Leu Asp Gly Ile Met Arg Lys Ala Cys Arg Asn 65 70 75 80 Arg Pro Leu Ser Glu Thr Gln Thr Lys Arg Asn Arg Tyr Leu Ser Lys 85 90 95 Thr Arg Tyr Ser Gly Leu Asn Leu Asn Gln Asp Lys Ala Thr Lys Pro 100 105 110 Gln Thr Val Gln Ile Val Arg Gln Gly Glu Ala Thr Pro Tyr Trp Phe 115 120 125 Lys Phe Asn Pro Leu Tyr Val Val Glu Gln Ser Phe Gly Thr Leu His 130 135 140 Arg Lys Phe Arg Tyr Ala Arg Ala Ala Tyr Phe Gly Leu Ile Lys Val 145 150 155 160 Ser Ala Gln Ser His Leu Lys Ala Met Cys Leu Asn Leu Leu Lys Ala 165 170 175 Ala Asn Lys Leu Ser Ala Pro Ala Ala Ala 180 185 <210> 151 <211> 1332 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1332) <400> 151 atg act gac ctg aac acc ctg ttt gcc aac ctc aaa caa cgc aat ccc 48 Met Thr Asp Leu Asn Thr Leu Phe Ala Asn Leu Lys Gln Arg Asn Pro 1 5 10 15 aat cag gag ccg ttc cat cag gcg gtt gaa gaa gtc ttc atg agt ctc 96 Asn Gln Glu Pro Phe His Gln Ala Val Glu Glu Val Phe Met Ser Leu 20 25 30 gat ccg ttt ttg gca aaa aat ccg aaa tac acc cag caa agc ctg ctg 144 Asp Pro Phe Leu Ala Lys Asn Pro Lys Tyr Thr Gln Gln Ser Leu Leu 35 40 45 gaa cgc atc gtc gaa ccc gaa cgc gtc gtg atg ttc cgc gta acc tgg 192 Glu Arg Ile Val Glu Pro Glu Arg Val Val Met Phe Arg Val Thr Trp 50 55 60 cag gac gat aaa ggg caa gtc caa gtc aac cgg ggc tac cgc gtg caa 240 Gln Asp Asp Lys Gly Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln 65 70 75 80 atg agt tcc gcc atc ggt cct tac aaa ggc ggc ctg cgc ttc cat ccg 288 Met Ser Ser Ala Ile Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro 85 90 95 acc gtc gat ttg ggc gta ttg aaa ttc ctc gct ttt gaa caa gtg ttc 336 Thr Val Asp Leu Gly Val Leu Lys Phe Leu Ala Phe Glu Gln Val Phe 100 105 110 aaa aac gcc ttg acc acc ctg cct atg ggc ggc ggc aaa ggc ggt tcc 384 Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys Gly Gly Ser 115 120 125 gac ttc gac ccc aaa ggc aaa tcc gat gcc gaa gta atg cgc ttc tgc 432 Asp Phe Asp Pro Lys Gly Lys Ser Asp Ala Glu Val Met Arg Phe Cys 130 135 140 caa gcc ttt atg acc gaa ctc tac cgc cac atc ggc gcg gac acc gat 480 Gln Ala Phe Met Thr Glu Leu Tyr Arg His Ile Gly Ala Asp Thr Asp 145 150 155 160 gtt ccg gcc ggc gac atc ggc gta ggc ggg cgc gaa atc ggc tac ctg 528 Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Ile Gly Tyr Leu 165 170 175 ttc gga caa tac aaa aaa atc cgc aac gag ttt tct tcc gtc ctg acc 576 Phe Gly Gln Tyr Lys Lys Ile Arg Asn Glu Phe Ser Ser Val Leu Thr 180 185 190 ggc aaa ggt ttg gaa tgg ggc ggc agc ctc atc cgt ccc gaa gcg acc 624 Gly Lys Gly Leu Glu Trp Gly Gly Ser Leu Ile Arg Pro Glu Ala Thr 195 200 205 ggc tac ggc tgc gtc tat ttc gcc caa gcg atg ctg caa acc cgc aac 672 Gly Tyr Gly Cys Val Tyr Phe Ala Gln Ala Met Leu Gln Thr Arg Asn 210 215 220 gat agt ttt gaa ggc aaa cgc gtc ctg att tcc ggt tcc ggc aac gtg 720 Asp Ser Phe Glu Gly Lys Arg Val Leu Ile Ser Gly Ser Gly Asn Val 225 230 235 240 gcg caa tac gcc gcc gaa aaa gcc atc caa ctg ggc gcg aaa gtg ctg 768 Ala Gln Tyr Ala Ala Glu Lys Ala Ile Gln Leu Gly Ala Lys Val Leu 245 250 255 acc gtt tcc gac tcc aac ggc ttc gtc ctc ttc ccc gac agc ggt atg 816 Thr Val Ser Asp Ser Asn Gly Phe Val Leu Phe Pro Asp Ser Gly Met 260 265 270 agc gaa gcg caa ctc gcc gcc ttg atc gaa ttg aaa gaa gtc cgc cgc 864 Ser Glu Ala Gln Leu Ala Ala Leu Ile Glu Leu Lys Glu Val Arg Arg 275 280 285 gaa cgg gtt gcc acc tac gcc aaa gag caa ggt ctg caa tac ttt gaa 912 Glu Arg Val Ala Thr Tyr Ala Lys Glu Gln Gly Leu Gln Tyr Phe Glu 290 295 300 aac caa aaa ccg tgg ggc gtc gcc gcc gaa atc gcc ctg ccc tgc gcg 960 Asn Gln Lys Pro Trp Gly Val Ala Ala Glu Ile Ala Leu Pro Cys Ala 305 310 315 320 acc cag aac gaa ttg gac gaa gaa gcc gcc aaa acc ctg ttg gca aac 1008 Thr Gln Asn Glu Leu Asp Glu Glu Ala Ala Lys Thr Leu Leu Ala Asn 325 330 335 ggc tgc tac gtc gtt gcc gaa ggt gcg aat atg ccg tcg act ttg ggc 1056 Gly Cys Tyr Val Val Ala Glu Gly Ala Asn Met Pro Ser Thr Leu Gly 340 345 350 gcg gtc gag caa ttt atc aaa gcc ggc atc ctc tac gcc ccg ggc aaa 1104 Ala Val Glu Gln Phe Ile Lys Ala Gly Ile Leu Tyr Ala Pro Gly Lys 355 360 365 gcc tcc aac gcc ggc ggc gta gca act tca ggt ttg gaa atg agc caa 1152 Ala Ser Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met Ser Gln 370 375 380 aac gcc atc cgc ctg tct tgg act cgt gaa gaa gtc gac caa cgc ctg 1200 Asn Ala Ile Arg Leu Ser Trp Thr Arg Glu Glu Val Asp Gln Arg Leu 385 390 395 400 ttc ggc atc atg caa agc atc cac gaa tcc tgt ctg aaa tac ggc aaa 1248 Phe Gly Ile Met Gln Ser Ile His Glu Ser Cys Leu Lys Tyr Gly Lys 405 410 415 gtc ggc gac aca gta aac tac gtc aat ggt gcg aac att gcc ggt ttc 1296 Val Gly Asp Thr Val Asn Tyr Val Asn Gly Ala Asn Ile Ala Gly Phe 420 425 430 gtc aaa gtt gcc gat gcg atg ctg gcg caa ggc ttc 1332 Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Phe 435 440 <210> 152 <211> 444 <212> PRT <213> Neisseria meningitidis <400> 152 Met Thr Asp Leu Asn Thr Leu Phe Ala Asn Leu Lys Gln Arg Asn Pro 1 5 10 15 Asn Gln Glu Pro Phe His Gln Ala Val Glu Glu Val Phe Met Ser Leu 20 25 30 Asp Pro Phe Leu Ala Lys Asn Pro Lys Tyr Thr Gln Gln Ser Leu Leu 35 40 45 Glu Arg Ile Val Glu Pro Glu Arg Val Val Met Phe Arg Val Thr Trp 50 55 60 Gln Asp Asp Lys Gly Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln 65 70 75 80 Met Ser Ser Ala Ile Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro 85 90 95 Thr Val Asp Leu Gly Val Leu Lys Phe Leu Ala Phe Glu Gln Val Phe 100 105 110 Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys Gly Gly Ser 115 120 125 Asp Phe Asp Pro Lys Gly Lys Ser Asp Ala Glu Val Met Arg Phe Cys 130 135 140 Gln Ala Phe Met Thr Glu Leu Tyr Arg His Ile Gly Ala Asp Thr Asp 145 150 155 160 Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Ile Gly Tyr Leu 165 170 175 Phe Gly Gln Tyr Lys Lys Ile Arg Asn Glu Phe Ser Ser Val Leu Thr 180 185 190 Gly Lys Gly Leu Glu Trp Gly Gly Ser Leu Ile Arg Pro Glu Ala Thr 195 200 205 Gly Tyr Gly Cys Val Tyr Phe Ala Gln Ala Met Leu Gln Thr Arg Asn 210 215 220 Asp Ser Phe Glu Gly Lys Arg Val Leu Ile Ser Gly Ser Gly Asn Val 225 230 235 240 Ala Gln Tyr Ala Ala Glu Lys Ala Ile Gln Leu Gly Ala Lys Val Leu 245 250 255 Thr Val Ser Asp Ser Asn Gly Phe Val Leu Phe Pro Asp Ser Gly Met 260 265 270 Ser Glu Ala Gln Leu Ala Ala Leu Ile Glu Leu Lys Glu Val Arg Arg 275 280 285 Glu Arg Val Ala Thr Tyr Ala Lys Glu Gln Gly Leu Gln Tyr Phe Glu 290 295 300 Asn Gln Lys Pro Trp Gly Val Ala Ala Glu Ile Ala Leu Pro Cys Ala 305 310 315 320 Thr Gln Asn Glu Leu Asp Glu Glu Ala Ala Lys Thr Leu Leu Ala Asn 325 330 335 Gly Cys Tyr Val Val Ala Glu Gly Ala Asn Met Pro Ser Thr Leu Gly 340 345 350 Ala Val Glu Gln Phe Ile Lys Ala Gly Ile Leu Tyr Ala Pro Gly Lys 355 360 365 Ala Ser Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met Ser Gln 370 375 380 Asn Ala Ile Arg Leu Ser Trp Thr Arg Glu Glu Val Asp Gln Arg Leu 385 390 395 400 Phe Gly Ile Met Gln Ser Ile His Glu Ser Cys Leu Lys Tyr Gly Lys 405 410 415 Val Gly Asp Thr Val Asn Tyr Val Asn Gly Ala Asn Ile Ala Gly Phe 420 425 430 Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Phe 435 440 <210> 153 <211> 867 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(867) <400> 153 atg aaa ccc ata cgg aaa gcc gtc ttc ccc gtc gca ggg atg gga aca 48 Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr 1 5 10 15 cgc ttc ctg ccc gcc acc aag gca agc ccg aaa gaa atg ctg ccc atc 96 Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile 20 25 30 gtc gac aag ccg ctg atc caa tac gcc gta gaa gaa gcc gtg gaa gcc 144 Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala 35 40 45 ggc tgc acg gaa atg gtg ttt gtt acc gga cgc aac aaa cgc agc atc 192 Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile 50 55 60 gaa gac cat ttc gac aag gca tac gaa ctc gaa acc gag ttg gaa atg 240 Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met 65 70 75 80 cgc cat aaa gac aaa ttg ttg gaa cac gtc cgc aac atc ctg ccg ccg 288 Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro 85 90 95 aac att acc tgc ctc tac atc cgt cag gcg gaa gca ctg ggc ttg gga 336 Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly 100 105 110 cac gcc gtc ttg tgc gcc cgc gcc gcc atc ggc gac gaa ccc ttt gcc 384 His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala 115 120 125 gtg att ttg gct gac gat tta atc gat gcc caa aaa ggc gcg ctc aaa 432 Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys 130 135 140 caa atg gtc gaa gtg tac gaa cgc agc ggc aac agc att ttg ggc gta 480 Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val 145 150 155 160 gaa act gtc gaa ccg tcg caa acc ggc tca tac ggc atc gtc gaa acc 528 Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr 165 170 175 gaa cag ctc aaa cag ttc caa cgc att acc ggc att gtc gaa aaa ccc 576 Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro 180 185 190 aag ccc gaa gac gcg ccc tcc aac ctt gcc gtc gtc gga cgc tac atc 624 Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile 195 200 205 ctt acc ccg cgc att ttc gac tta ctg acc gga ctg ccg cgc ggc gcg 672 Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala 210 215 220 ggc aac gaa atc cag ctt aca gac ggc atc gcc aag ctg ctc gat cac 720 Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His 225 230 235 240 gaa ttt gtc cta gcg cac ccc ttt gaa ggc acg cgc tac gac tgc ggc 768 Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly 245 250 255 agc aaa ctg ggc tat ctg gaa gcc acc gtc gcc tac ggc ctg aaa cac 816 Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His 260 265 270 ccc gaa acc ggc gaa ccc ttc cgc cgc ctt ttg gaa aaa tac cgt acc 864 Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr 275 280 285 gaa 867 Glu <210> 154 <211> 289 <212> PRT <213> Neisseria meningitidis <400> 154 Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr 1 5 10 15 Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile 20 25 30 Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala 35 40 45 Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile 50 55 60 Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met 65 70 75 80 Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro 85 90 95 Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly 100 105 110 His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala 115 120 125 Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys 130 135 140 Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val 145 150 155 160 Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr 165 170 175 Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro 180 185 190 Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile 195 200 205 Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala 210 215 220 Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His 225 230 235 240 Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly 245 250 255 Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His 260 265 270 Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr 275 280 285 Glu <210> 155 <211> 876 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(876) <400> 155 ttg acc gtc cga acg aaa aag acg gcg cat tat acc cta ttc cat tcc 48 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 gac cga aaa ccg aac atg act act ctc aaa ccc gcc ctg ccc gct tat 96 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 ctg gac aac atc cgc atc atc ctc acg cgc acc agc cat ccc gcc aac 144 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 atc ggc tct gcc gcg cgc gcg atg aaa aca atg ggt ctg cac aaa ctg 192 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 acc atc gtc gcc cca aat ctg atg gca acg ccg atg acg gaa aac ccg 240 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 ccc gtg ttt gac ccg gag cat cct caa tcg ttt aaa tta ccg gaa gaa 288 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 agc ttc atc ctc gct tcc ggc gcg gca gac gtt ttg gaa aat gcc acc 336 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 att gcc gct tct ttg gac gaa gcc ctt gcc gac acc acc atc gcc tgc 384 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 gcc ctg acc agc cgc cgc cgc gaa att act gcg ccg ctg caa acc ccg 432 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 cgc gat ttg gta tcc gaa tta ctg cag acc gca aac cga ggc gag aaa 480 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 gtg gca ctg gtt ttc ggc aac gag act ttc ggc ttg agc atc gaa gaa 528 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 gtc caa gcc tgc aac cga ctg atg acc atc aac ggc aat ccc gac tat 576 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 ttc tcg ctc aac ctc gcc caa gcc gtg cag gtc gtg tgc tac gaa atc 624 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 ttc agc caa acc ggt tcg ccc atg acc cat ctt caa caa gaa gac cac 672 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 gct gcg acc cac gag caa atc aaa ggc atg gtc gcc cac atg gaa agc 720 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 gtg atg aac gac atc ggc ttt ttc aac cgc cgc aac ggc gag cgt ctg 768 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 atg cgc cgt atg cag agc ctg ttc gga cgc gcc aac acg caa acc gaa 816 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 gac atc gat atc ctg cgc ggt ttt ttc aat acc gtc agc cat cgt atc 864 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 cat aaa aaa gac 876 His Lys Lys Asp 290 <210> 156 <211> 292 <212> PRT <213> Neisseria meningitidis <400> 156 Leu Thr Val Arg Thr Lys Lys Thr Ala His Tyr Thr Leu Phe His Ser 1 5 10 15 Asp Arg Lys Pro Asn Met Thr Thr Leu Lys Pro Ala Leu Pro Ala Tyr 20 25 30 Leu Asp Asn Ile Arg Ile Ile Leu Thr Arg Thr Ser His Pro Ala Asn 35 40 45 Ile Gly Ser Ala Ala Arg Ala Met Lys Thr Met Gly Leu His Lys Leu 50 55 60 Thr Ile Val Ala Pro Asn Leu Met Ala Thr Pro Met Thr Glu Asn Pro 65 70 75 80 Pro Val Phe Asp Pro Glu His Pro Gln Ser Phe Lys Leu Pro Glu Glu 85 90 95 Ser Phe Ile Leu Ala Ser Gly Ala Ala Asp Val Leu Glu Asn Ala Thr 100 105 110 Ile Ala Ala Ser Leu Asp Glu Ala Leu Ala Asp Thr Thr Ile Ala Cys 115 120 125 Ala Leu Thr Ser Arg Arg Arg Glu Ile Thr Ala Pro Leu Gln Thr Pro 130 135 140 Arg Asp Leu Val Ser Glu Leu Leu Gln Thr Ala Asn Arg Gly Glu Lys 145 150 155 160 Val Ala Leu Val Phe Gly Asn Glu Thr Phe Gly Leu Ser Ile Glu Glu 165 170 175 Val Gln Ala Cys Asn Arg Leu Met Thr Ile Asn Gly Asn Pro Asp Tyr 180 185 190 Phe Ser Leu Asn Leu Ala Gln Ala Val Gln Val Val Cys Tyr Glu Ile 195 200 205 Phe Ser Gln Thr Gly Ser Pro Met Thr His Leu Gln Gln Glu Asp His 210 215 220 Ala Ala Thr His Glu Gln Ile Lys Gly Met Val Ala His Met Glu Ser 225 230 235 240 Val Met Asn Asp Ile Gly Phe Phe Asn Arg Arg Asn Gly Glu Arg Leu 245 250 255 Met Arg Arg Met Gln Ser Leu Phe Gly Arg Ala Asn Thr Gln Thr Glu 260 265 270 Asp Ile Asp Ile Leu Arg Gly Phe Phe Asn Thr Val Ser His Arg Ile 275 280 285 His Lys Lys Asp 290 <210> 157 <211> 1008 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1008) <400> 157 atg tcc atc aaa atc ctg att att tcc ccc agt tgg ata ggc gac tgc 48 Met Ser Ile Lys Ile Leu Ile Ile Ser Pro Ser Trp Ile Gly Asp Cys 1 5 10 15 gtg atg acc cag ccc ttg ttc cgc cgt ttg aag gaa ctt cac ccc ggt 96 Val Met Thr Gln Pro Leu Phe Arg Arg Leu Lys Glu Leu His Pro Gly 20 25 30 tgc acg att gat gtg ttc gca ccg aag tgg tcg atg gcg gtg ttt gag 144 Cys Thr Ile Asp Val Phe Ala Pro Lys Trp Ser Met Ala Val Phe Glu 35 40 45 cgt atg ccg gaa gtg aat gag att ctt gaa aat ccg ttc gga cac ggt 192 Arg Met Pro Glu Val Asn Glu Ile Leu Glu Asn Pro Phe Gly His Gly 50 55 60 gcg ttg gag ttg aaa cgc cgt tgg cgg gtc ggt agg gat ttg ggg cgg 240 Ala Leu Glu Leu Lys Arg Arg Trp Arg Val Gly Arg Asp Leu Gly Arg 65 70 75 80 cgc gga tac gat cag gtt atc gtg ttg ccc ggt tct ttg aaa tcg gca 288 Arg Gly Tyr Asp Gln Val Ile Val Leu Pro Gly Ser Leu Lys Ser Ala 85 90 95 atc atc gcg ctg gcg aca ggt atc ggt aaa agg acg ggt tat gtc ggt 336 Ile Ile Ala Leu Ala Thr Gly Ile Gly Lys Arg Thr Gly Tyr Val Gly 100 105 110 gaa agc cgt tat ttt ctg ttg aac gat ata cgc agg ctg gat aag gaa 384 Glu Ser Arg Tyr Phe Leu Leu Asn Asp Ile Arg Arg Leu Asp Lys Glu 115 120 125 cgt ctg cct ttg atg gtg gac aga tat acg gct ctc gcg cat ccg agc 432 Arg Leu Pro Leu Met Val Asp Arg Tyr Thr Ala Leu Ala His Pro Ser 130 135 140 cag gag gat ttt gac ggg cat tcg gga ttc ccc gag ttt tcc att gat 480 Gln Glu Asp Phe Asp Gly His Ser Gly Phe Pro Glu Phe Ser Ile Asp 145 150 155 160 gaa cgg cgg cgg gaa att tct gtc gaa acc ttt ggc ttg gat att gga 528 Glu Arg Arg Arg Glu Ile Ser Val Glu Thr Phe Gly Leu Asp Ile Gly 165 170 175 aag cct gtt ctg gct ttt tgt ccg ggt gcg gaa ttc ggg ccg gca aag 576 Lys Pro Val Leu Ala Phe Cys Pro Gly Ala Glu Phe Gly Pro Ala Lys 180 185 190 cgt tgg ccg aca agg tat ttt gcc gag ttg ggc aaa cat tat tcg gcg 624 Arg Trp Pro Thr Arg Tyr Phe Ala Glu Leu Gly Lys His Tyr Ser Ala 195 200 205 gcg ggt tgg cag gtt tgg ctg ttc ggt tcg caa aaa gat gat gaa att 672 Ala Gly Trp Gln Val Trp Leu Phe Gly Ser Gln Lys Asp Asp Glu Ile 210 215 220 gcc gag gaa atc aac tgc ctt tca gac ggt atg tgt gtc aat ttg tgc 720 Ala Glu Glu Ile Asn Cys Leu Ser Asp Gly Met Cys Val Asn Leu Cys 225 230 235 240 ggc aaa acc gat ttg tcg cag gca atg gat ttg ctg tcg ttg gcg gac 768 Gly Lys Thr Asp Leu Ser Gln Ala Met Asp Leu Leu Ser Leu Ala Asp 245 250 255 acg gtc gtg tgc aac gac agc ggg ctg atg cac ttg gcg gcg gca ttg 816 Thr Val Val Cys Asn Asp Ser Gly Leu Met His Leu Ala Ala Ala Leu 260 265 270 ggc agg aag gtg gtg gcg gtt tac ggt tct tcc agc ccg acg cat acg 864 Gly Arg Lys Val Val Ala Val Tyr Gly Ser Ser Ser Pro Thr His Thr 275 280 285 ccg cct ttg agc gac agg gcg aaa atc gtc agc ctg cac ttg gaa tgt 912 Pro Pro Leu Ser Asp Arg Ala Lys Ile Val Ser Leu His Leu Glu Cys 290 295 300 tcg ccc tgt ttt aag cgg gaa tgt ccg ctg ggg cat acc gac tgc ctc 960 Ser Pro Cys Phe Lys Arg Glu Cys Pro Leu Gly His Thr Asp Cys Leu 305 310 315 320 aac agg ctg tat ccc gag aag att gtg cag gcg gtt gaa gag gcg gta 1008 Asn Arg Leu Tyr Pro Glu Lys Ile Val Gln Ala Val Glu Glu Ala Val 325 330 335 <210> 158 <211> 336 <212> PRT <213> Neisseria meningitidis <400> 158 Met Ser Ile Lys Ile Leu Ile Ile Ser Pro Ser Trp Ile Gly Asp Cys 1 5 10 15 Val Met Thr Gln Pro Leu Phe Arg Arg Leu Lys Glu Leu His Pro Gly 20 25 30 Cys Thr Ile Asp Val Phe Ala Pro Lys Trp Ser Met Ala Val Phe Glu 35 40 45 Arg Met Pro Glu Val Asn Glu Ile Leu Glu Asn Pro Phe Gly His Gly 50 55 60 Ala Leu Glu Leu Lys Arg Arg Trp Arg Val Gly Arg Asp Leu Gly Arg 65 70 75 80 Arg Gly Tyr Asp Gln Val Ile Val Leu Pro Gly Ser Leu Lys Ser Ala 85 90 95 Ile Ile Ala Leu Ala Thr Gly Ile Gly Lys Arg Thr Gly Tyr Val Gly 100 105 110 Glu Ser Arg Tyr Phe Leu Leu Asn Asp Ile Arg Arg Leu Asp Lys Glu 115 120 125 Arg Leu Pro Leu Met Val Asp Arg Tyr Thr Ala Leu Ala His Pro Ser 130 135 140 Gln Glu Asp Phe Asp Gly His Ser Gly Phe Pro Glu Phe Ser Ile Asp 145 150 155 160 Glu Arg Arg Arg Glu Ile Ser Val Glu Thr Phe Gly Leu Asp Ile Gly 165 170 175 Lys Pro Val Leu Ala Phe Cys Pro Gly Ala Glu Phe Gly Pro Ala Lys 180 185 190 Arg Trp Pro Thr Arg Tyr Phe Ala Glu Leu Gly Lys His Tyr Ser Ala 195 200 205 Ala Gly Trp Gln Val Trp Leu Phe Gly Ser Gln Lys Asp Asp Glu Ile 210 215 220 Ala Glu Glu Ile Asn Cys Leu Ser Asp Gly Met Cys Val Asn Leu Cys 225 230 235 240 Gly Lys Thr Asp Leu Ser Gln Ala Met Asp Leu Leu Ser Leu Ala Asp 245 250 255 Thr Val Val Cys Asn Asp Ser Gly Leu Met His Leu Ala Ala Ala Leu 260 265 270 Gly Arg Lys Val Val Ala Val Tyr Gly Ser Ser Ser Pro Thr His Thr 275 280 285 Pro Pro Leu Ser Asp Arg Ala Lys Ile Val Ser Leu His Leu Glu Cys 290 295 300 Ser Pro Cys Phe Lys Arg Glu Cys Pro Leu Gly His Thr Asp Cys Leu 305 310 315 320 Asn Arg Leu Tyr Pro Glu Lys Ile Val Gln Ala Val Glu Glu Ala Val 325 330 335 <210> 159 <211> 381 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(381) <400> 159 atg gaa cct tcc tcc tac gcg gca gaa aaa aaa gga aaa ggc ggc atc 48 Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile 1 5 10 15 agg cgc gtc atc aac gca ttc ggc tat tcg ata gac ggc atc gcc gcc 96 Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala 20 25 30 gcc tac cgt tac gaa gcg gca ttc cgt cag gtt ttg tgg ctg aac gcg 144 Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala 35 40 45 ctg ctg gtg tgc gcg gca ttt ttt tgg gtt tcc gaa aag tcc ctc cgc 192 Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg 50 55 60 ctg ccg ttg att atc gcg tct ttt gtg tcg gtc att gtc gaa ctg ttc 240 Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe 65 70 75 80 aac act gcc gtc gaa gcc gcc gtc gat cat act tcg act gaa aaa cac 288 Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His 85 90 95 gag ctg gct aaa cgc gcc aaa gac gca ggt tct gct gca caa ttg ttc 336 Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe 100 105 110 gcg atg ctg atg tta gcg gcg gtt tgg ctg tcc gcc ctg ttc ggg 381 Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly 115 120 125 <210> 160 <211> 127 <212> PRT <213> Neisseria meningitidis <400> 160 Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile 1 5 10 15 Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala 20 25 30 Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala 35 40 45 Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg 50 55 60 Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe 65 70 75 80 Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His 85 90 95 Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe 100 105 110 Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly 115 120 125 <210> 161 <211> 990 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(990) <400> 161 atg aaa aaa gaa agc cgc ccc gcg ttt gac gcg gca gcc gta ttt gac 48 Met Lys Lys Glu Ser Arg Pro Ala Phe Asp Ala Ala Ala Val Phe Asp 1 5 10 15 gcg gca gcc gta ccg gta tcc gac agc ggg ttt gcc gcc aat gca aat 96 Ala Ala Ala Val Pro Val Ser Asp Ser Gly Phe Ala Ala Asn Ala Asn 20 25 30 gtc cgc cgt ttt gtg gac gat gaa gtc ggg aaa ggg gat ttt tcc cgg 144 Val Arg Arg Phe Val Asp Asp Glu Val Gly Lys Gly Asp Phe Ser Arg 35 40 45 gcg gaa tgg cag gat ttt ttt gac aaa gcg gct tac aag gcg gac atc 192 Ala Glu Trp Gln Asp Phe Phe Asp Lys Ala Ala Tyr Lys Ala Asp Ile 50 55 60 gtc aag att atg cac cgc ccc tcc aca tcg cgt ccg tgg tat gtg ttc 240 Val Lys Ile Met His Arg Pro Ser Thr Ser Arg Pro Trp Tyr Val Phe 65 70 75 80 cgc acg gga aat tcg ggc aag gcg aaa ttt cgc ggc gcg cgc cgg ttt 288 Arg Thr Gly Asn Ser Gly Lys Ala Lys Phe Arg Gly Ala Arg Arg Phe 85 90 95 tat gcg gaa aac cgc gcg ctt atc gat gat gtg gcg caa aaa tac ggc 336 Tyr Ala Glu Asn Arg Ala Leu Ile Asp Asp Val Ala Gln Lys Tyr Gly 100 105 110 gtg cct gcc gaa ctt atc gtg gcg gtt atc ggg att gaa acg aat tac 384 Val Pro Ala Glu Leu Ile Val Ala Val Ile Gly Ile Glu Thr Asn Tyr 115 120 125 ggc aaa aat acg ggc agt ttc cgt gtg gcg gac gca ttg gcg acc tta 432 Gly Lys Asn Thr Gly Ser Phe Arg Val Ala Asp Ala Leu Ala Thr Leu 130 135 140 ggc ttt gat tac ccc cgc cgc gcc ggg ttt ttc caa aaa gaa ttg gtc 480 Gly Phe Asp Tyr Pro Arg Arg Ala Gly Phe Phe Gln Lys Glu Leu Val 145 150 155 160 gag ctt tta aag ctg gca aaa gaa gaa ggc ggc gat gtt ttc gcc ttt 528 Glu Leu Leu Lys Leu Ala Lys Glu Glu Gly Gly Asp Val Phe Ala Phe 165 170 175 aaa ggc agc tat gcg ggc gca atg ggg atg ccg caa ttt atg cct tcg 576 Lys Gly Ser Tyr Ala Gly Ala Met Gly Met Pro Gln Phe Met Pro Ser 180 185 190 agc tac cgg aaa tgg gcg gtg gat tat gac ggg gac gga cat cgg gac 624 Ser Tyr Arg Lys Trp Ala Val Asp Tyr Asp Gly Asp Gly His Arg Asp 195 200 205 ata tgg ggc aat gtt ggc gat gtc gcg gca tcg att gcc aat tat atg 672 Ile Trp Gly Asn Val Gly Asp Val Ala Ala Ser Ile Ala Asn Tyr Met 210 215 220 aag cag cac ggt tgg cgc acg ggc ggg aaa ata ctg gtg tct gca aca 720 Lys Gln His Gly Trp Arg Thr Gly Gly Lys Ile Leu Val Ser Ala Thr 225 230 235 240 ttg gcg ccg ggt gcg gat gtt cag gca atc att ggc gaa aaa acc gcc 768 Leu Ala Pro Gly Ala Asp Val Gln Ala Ile Ile Gly Glu Lys Thr Ala 245 250 255 ctg acg cgg acg gtg gcg gat ttg aag gcg tac ggc atc atc ccc ggc 816 Leu Thr Arg Thr Val Ala Asp Leu Lys Ala Tyr Gly Ile Ile Pro Gly 260 265 270 gaa gag ctt gcc gat gat gaa aag gcg gtt ttg ttc aaa ctg gaa acc 864 Glu Glu Leu Ala Asp Asp Glu Lys Ala Val Leu Phe Lys Leu Glu Thr 275 280 285 gca ccc ggc gtg ttt gaa tat tat ttg ggc ttg aac aat ttt tat acg 912 Ala Pro Gly Val Phe Glu Tyr Tyr Leu Gly Leu Asn Asn Phe Tyr Thr 290 295 300 gta tgg cag tac aat cac agt cgg atg tat gta acg gcg gtc agg gac 960 Val Trp Gln Tyr Asn His Ser Arg Met Tyr Val Thr Ala Val Arg Asp 305 310 315 320 att gcc aat tcg ctt ggc ggc ccg gga ttg 990 Ile Ala Asn Ser Leu Gly Gly Pro Gly Leu 325 330 <210> 162 <211> 330 <212> PRT <213> Neisseria meningitidis <400> 162 Met Lys Lys Glu Ser Arg Pro Ala Phe Asp Ala Ala Ala Val Phe Asp 1 5 10 15 Ala Ala Ala Val Pro Val Ser Asp Ser Gly Phe Ala Ala Asn Ala Asn 20 25 30 Val Arg Arg Phe Val Asp Asp Glu Val Gly Lys Gly Asp Phe Ser Arg 35 40 45 Ala Glu Trp Gln Asp Phe Phe Asp Lys Ala Ala Tyr Lys Ala Asp Ile 50 55 60 Val Lys Ile Met His Arg Pro Ser Thr Ser Arg Pro Trp Tyr Val Phe 65 70 75 80 Arg Thr Gly Asn Ser Gly Lys Ala Lys Phe Arg Gly Ala Arg Arg Phe 85 90 95 Tyr Ala Glu Asn Arg Ala Leu Ile Asp Asp Val Ala Gln Lys Tyr Gly 100 105 110 Val Pro Ala Glu Leu Ile Val Ala Val Ile Gly Ile Glu Thr Asn Tyr 115 120 125 Gly Lys Asn Thr Gly Ser Phe Arg Val Ala Asp Ala Leu Ala Thr Leu 130 135 140 Gly Phe Asp Tyr Pro Arg Arg Ala Gly Phe Phe Gln Lys Glu Leu Val 145 150 155 160 Glu Leu Leu Lys Leu Ala Lys Glu Glu Gly Gly Asp Val Phe Ala Phe 165 170 175 Lys Gly Ser Tyr Ala Gly Ala Met Gly Met Pro Gln Phe Met Pro Ser 180 185 190 Ser Tyr Arg Lys Trp Ala Val Asp Tyr Asp Gly Asp Gly His Arg Asp 195 200 205 Ile Trp Gly Asn Val Gly Asp Val Ala Ala Ser Ile Ala Asn Tyr Met 210 215 220 Lys Gln His Gly Trp Arg Thr Gly Gly Lys Ile Leu Val Ser Ala Thr 225 230 235 240 Leu Ala Pro Gly Ala Asp Val Gln Ala Ile Ile Gly Glu Lys Thr Ala 245 250 255 Leu Thr Arg Thr Val Ala Asp Leu Lys Ala Tyr Gly Ile Ile Pro Gly 260 265 270 Glu Glu Leu Ala Asp Asp Glu Lys Ala Val Leu Phe Lys Leu Glu Thr 275 280 285 Ala Pro Gly Val Phe Glu Tyr Tyr Leu Gly Leu Asn Asn Phe Tyr Thr 290 295 300 Val Trp Gln Tyr Asn His Ser Arg Met Tyr Val Thr Ala Val Arg Asp 305 310 315 320 Ile Ala Asn Ser Leu Gly Gly Pro Gly Leu 325 330 <210> 163 <211> 1773 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1773) <400> 163 atg agt atc gtg ctg cac ggc gtg gcg gcg ggc aaa ggc att gcc gtc 48 Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val 1 5 10 15 ggt tgc gcc cac ctg att gcg cgc ggt acg gag gaa gtg ccg cag tat 96 Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr 20 25 30 gat gtt gcg gag gcg gac acc gat gcc gaa gcc gaa cgt ttc gat gcc 144 Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala 35 40 45 gcc gtc aaa gcc acg cgc aaa gag ttg gaa cag ctc cgc agc gcg att 192 Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile 50 55 60 ccc gaa aac gcc ccg acc gag ttg ggc gcg ttc atc tcg ctg cac ctg 240 Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu 65 70 75 80 atg ctc ttg acc gat gtt acc ttg tcg cgc gaa ccc gtc gat att tta 288 Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu 85 90 95 agg gaa caa aaa atc aac gcc gag tgg gca ttg aag cag cag agc gac 336 Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp 100 105 110 aaa ctc gcc gcc caa ttc gac aat atg gac gat gcc tat ttg cgc gaa 384 Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu 115 120 125 cgc aag cag gat atg ctg caa gtc gtc cgc cgc atc cac aac aac ctg 432 Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu 130 135 140 atc ggg cag ggc aac gag ttg gaa gtt gcc gac aac ctg ttt gac gaa 480 Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu 145 150 155 160 acc gtt ctg att gca aac gac ctt tcg ccc gcc gac acg gtt ttg ttt 528 Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe 165 170 175 aaa gag cag cgc att gcc gcc ttc gtt acc gat gcc ggc ggc ccc acc 576 Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr 180 185 190 ggg cat acg gcg att ttg ggc agg agc ttg gac atc ccg tcc gtc gtc 624 Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val 195 200 205 ggg ctg cac aac gcg cgc aaa ctg att acc gag ggc gaa acg gtc att 672 Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile 210 215 220 gtg gac ggt atc aac ggc gtg ttg att atc gcg ccg gat gag tcg gtg 720 Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val 225 230 235 240 ttg aac gaa tac cgc cgc cgt gcc cgc gaa tac cgc agc cac aaa cgc 768 Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg 245 250 255 gat ttg aac aag ctc aaa aaa acc gcc gcc gcc acc gct gac ggg gtc 816 Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val 260 265 270 tgc atc gag ctt gtg ggc aat ata gaa tcc gcc gaa gac gtg aaa ccg 864 Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro 275 280 285 ctg cac aac ctc ggc gca gac ggc atc ggg ctg ttc cgc agc gag ttt 912 Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe 290 295 300 ctt tac ctg aac cgc gat acg atg ccg tct gaa gac gag cag tac gaa 960 Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu 305 310 315 320 gtg tac agc gcg att gtc aaa aaa atg aaa ggc aaa agc gta acg ata 1008 Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile 325 330 335 cgg aca gtc gat ttg ggt gtg gac aaa aac ccg cgc tgg ttc ggg aaa 1056 Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys 340 345 350 aac agc acg ccc aac ggc agc ctc aac ccc gcg ctg ggc atg acc ggc 1104 Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly 355 360 365 atc cgc ctg tgc ctt gcc gaa ccg gtc atg ttc cgc acc cag atg cgc 1152 Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg 370 375 380 gcc atc ctc cgc gcc gcc gcc cac ggc ccc gtg cgg atg atg tgg ccg 1200 Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro 385 390 395 400 atg att acc tcc gta tcc gaa gtg cgc cag tgc ctc atc cac ctc gac 1248 Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp 405 410 415 acc gcg caa cgc cag ctt gcc gaa cgc ggc gat gcc ttc ggt aaa gtc 1296 Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val 420 425 430 ggc atc ggc tgt atg att gaa att ccg tct gcc gcg ctg acc gtc ggc 1344 Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly 435 440 445 agt att ttg aaa ctg gtc gat ttc atc tcc gtc ggt acc aac gac ctg 1392 Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu 450 455 460 att caa tac atc ttg tcc gtc gat cgc ggc gac gac agc gtc agc cac 1440 Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His 465 470 475 480 ctc tac cag ccc ggc cat ccc gcc gtg ctg aaa atg ctg caa cac gtc 1488 Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val 485 490 495 atc cgt acc gcc aac cgc atg gac aaa gac gta tcc gta tgc ggc gag 1536 Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu 500 505 510 atg gcg ggc gat acc gcg ttt acc cgc gtt tta ttg ggt atg ggg ctg 1584 Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu 515 520 525 cgc cgt ttt tcc atg aac ccc aac aac atc ctg ccc gtc aaa aac atc 1632 Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile 530 535 540 att ctg cac agc aat gtc gga cag ctc gaa agc gat att gtg aaa gtc 1680 Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val 545 550 555 560 atc cgc tgc gaa gac gaa gag aag tcg gaa aag ctg atc aaa cag atg 1728 Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met 565 570 575 aac agc gtg tct gtc gag gaa gaa gcc gac ttc aag ggg cgg aaa 1773 Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys 580 585 590 <210> 164 <211> 591 <212> PRT <213> Neisseria meningitidis <400> 164 Met Ser Ile Val Leu His Gly Val Ala Ala Gly Lys Gly Ile Ala Val 1 5 10 15 Gly Cys Ala His Leu Ile Ala Arg Gly Thr Glu Glu Val Pro Gln Tyr 20 25 30 Asp Val Ala Glu Ala Asp Thr Asp Ala Glu Ala Glu Arg Phe Asp Ala 35 40 45 Ala Val Lys Ala Thr Arg Lys Glu Leu Glu Gln Leu Arg Ser Ala Ile 50 55 60 Pro Glu Asn Ala Pro Thr Glu Leu Gly Ala Phe Ile Ser Leu His Leu 65 70 75 80 Met Leu Leu Thr Asp Val Thr Leu Ser Arg Glu Pro Val Asp Ile Leu 85 90 95 Arg Glu Gln Lys Ile Asn Ala Glu Trp Ala Leu Lys Gln Gln Ser Asp 100 105 110 Lys Leu Ala Ala Gln Phe Asp Asn Met Asp Asp Ala Tyr Leu Arg Glu 115 120 125 Arg Lys Gln Asp Met Leu Gln Val Val Arg Arg Ile His Asn Asn Leu 130 135 140 Ile Gly Gln Gly Asn Glu Leu Glu Val Ala Asp Asn Leu Phe Asp Glu 145 150 155 160 Thr Val Leu Ile Ala Asn Asp Leu Ser Pro Ala Asp Thr Val Leu Phe 165 170 175 Lys Glu Gln Arg Ile Ala Ala Phe Val Thr Asp Ala Gly Gly Pro Thr 180 185 190 Gly His Thr Ala Ile Leu Gly Arg Ser Leu Asp Ile Pro Ser Val Val 195 200 205 Gly Leu His Asn Ala Arg Lys Leu Ile Thr Glu Gly Glu Thr Val Ile 210 215 220 Val Asp Gly Ile Asn Gly Val Leu Ile Ile Ala Pro Asp Glu Ser Val 225 230 235 240 Leu Asn Glu Tyr Arg Arg Arg Ala Arg Glu Tyr Arg Ser His Lys Arg 245 250 255 Asp Leu Asn Lys Leu Lys Lys Thr Ala Ala Ala Thr Ala Asp Gly Val 260 265 270 Cys Ile Glu Leu Val Gly Asn Ile Glu Ser Ala Glu Asp Val Lys Pro 275 280 285 Leu His Asn Leu Gly Ala Asp Gly Ile Gly Leu Phe Arg Ser Glu Phe 290 295 300 Leu Tyr Leu Asn Arg Asp Thr Met Pro Ser Glu Asp Glu Gln Tyr Glu 305 310 315 320 Val Tyr Ser Ala Ile Val Lys Lys Met Lys Gly Lys Ser Val Thr Ile 325 330 335 Arg Thr Val Asp Leu Gly Val Asp Lys Asn Pro Arg Trp Phe Gly Lys 340 345 350 Asn Ser Thr Pro Asn Gly Ser Leu Asn Pro Ala Leu Gly Met Thr Gly 355 360 365 Ile Arg Leu Cys Leu Ala Glu Pro Val Met Phe Arg Thr Gln Met Arg 370 375 380 Ala Ile Leu Arg Ala Ala Ala His Gly Pro Val Arg Met Met Trp Pro 385 390 395 400 Met Ile Thr Ser Val Ser Glu Val Arg Gln Cys Leu Ile His Leu Asp 405 410 415 Thr Ala Gln Arg Gln Leu Ala Glu Arg Gly Asp Ala Phe Gly Lys Val 420 425 430 Gly Ile Gly Cys Met Ile Glu Ile Pro Ser Ala Ala Leu Thr Val Gly 435 440 445 Ser Ile Leu Lys Leu Val Asp Phe Ile Ser Val Gly Thr Asn Asp Leu 450 455 460 Ile Gln Tyr Ile Leu Ser Val Asp Arg Gly Asp Asp Ser Val Ser His 465 470 475 480 Leu Tyr Gln Pro Gly His Pro Ala Val Leu Lys Met Leu Gln His Val 485 490 495 Ile Arg Thr Ala Asn Arg Met Asp Lys Asp Val Ser Val Cys Gly Glu 500 505 510 Met Ala Gly Asp Thr Ala Phe Thr Arg Val Leu Leu Gly Met Gly Leu 515 520 525 Arg Arg Phe Ser Met Asn Pro Asn Asn Ile Leu Pro Val Lys Asn Ile 530 535 540 Ile Leu His Ser Asn Val Gly Gln Leu Glu Ser Asp Ile Val Lys Val 545 550 555 560 Ile Arg Cys Glu Asp Glu Glu Lys Ser Glu Lys Leu Ile Lys Gln Met 565 570 575 Asn Ser Val Ser Val Glu Glu Glu Ala Asp Phe Lys Gly Arg Lys 580 585 590 <210> 165 <211> 381 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(381) <400> 165 atg gaa cct tcc tcc tac gcg gca gaa aaa aaa gga aaa ggc ggc atc 48 Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile 1 5 10 15 agg cgc gtc atc aac gca ttc ggc tat tcg ata gac ggc atc gcc gcc 96 Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala 20 25 30 gcc tac cgt tac gaa gcg gca ttc cgt cag gtt ttg tgg ctg aac gcg 144 Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala 35 40 45 ctg ctg gtg tgc gcg gca ttt ttt tgg gtt tcc gaa aag tcc ctc cgc 192 Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg 50 55 60 ctg ccg ttg att atc gcg tct ttt gtg tcg gtc att gtc gaa ctg ttc 240 Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe 65 70 75 80 aac act gcc gtc gaa gcc gcc gtc gat cat act tcg act gaa aaa cac 288 Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His 85 90 95 gag ctg gct aaa cgc gcc aaa gac gca ggt tct gct gca caa ttg ttc 336 Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe 100 105 110 gcg atg ctg atg tta gcg gcg gtt tgg ctg tcc gcc ctg ttc ggg 381 Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly 115 120 125 <210> 166 <211> 127 <212> PRT <213> Neisseria meningitidis <400> 166 Met Glu Pro Ser Ser Tyr Ala Ala Glu Lys Lys Gly Lys Gly Gly Ile 1 5 10 15 Arg Arg Val Ile Asn Ala Phe Gly Tyr Ser Ile Asp Gly Ile Ala Ala 20 25 30 Ala Tyr Arg Tyr Glu Ala Ala Phe Arg Gln Val Leu Trp Leu Asn Ala 35 40 45 Leu Leu Val Cys Ala Ala Phe Phe Trp Val Ser Glu Lys Ser Leu Arg 50 55 60 Leu Pro Leu Ile Ile Ala Ser Phe Val Ser Val Ile Val Glu Leu Phe 65 70 75 80 Asn Thr Ala Val Glu Ala Ala Val Asp His Thr Ser Thr Glu Lys His 85 90 95 Glu Leu Ala Lys Arg Ala Lys Asp Ala Gly Ser Ala Ala Gln Leu Phe 100 105 110 Ala Met Leu Met Leu Ala Ala Val Trp Leu Ser Ala Leu Phe Gly 115 120 125 <210> 167 <211> 1257 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1257) <400> 167 atg agt atg gca ctt gcc caa aaa ctt gcc gcc gac agc att gcg gcg 48 Met Ser Met Ala Leu Ala Gln Lys Leu Ala Ala Asp Ser Ile Ala Ala 1 5 10 15 gtt gcc gaa gga cgc aac ctt cag gac gtg ttg gcg caa atc cgc acc 96 Val Ala Glu Gly Arg Asn Leu Gln Asp Val Leu Ala Gln Ile Arg Thr 20 25 30 gcg cat ccc gac ctt acg gcg cag gaa aac ggc gcg ttg cag gac atc 144 Ala His Pro Asp Leu Thr Ala Gln Glu Asn Gly Ala Leu Gln Asp Ile 35 40 45 gcc tac ggc tgc cag cgt tat ttg ggc agt ttg aaa cat atg ctc gcg 192 Ala Tyr Gly Cys Gln Arg Tyr Leu Gly Ser Leu Lys His Met Leu Ala 50 55 60 cag atg ctg aaa aag ccg att ggc aat ccg cag ctc gaa agt ctg ctt 240 Gln Met Leu Lys Lys Pro Ile Gly Asn Pro Gln Leu Glu Ser Leu Leu 65 70 75 80 ttg gcg gcg ttg tac caa ctg cat tac acg cgc aac gcg ccg cat gct 288 Leu Ala Ala Leu Tyr Gln Leu His Tyr Thr Arg Asn Ala Pro His Ala 85 90 95 gtg gtc aac gaa gct gtt gaa agc atc gcc aaa atc gga cgc ggg cag 336 Val Val Asn Glu Ala Val Glu Ser Ile Ala Lys Ile Gly Arg Gly Gln 100 105 110 tac cgt tcg ttt gcc aac gcg att ttg cgc cgc ttt ttg cgc gaa cgc 384 Tyr Arg Ser Phe Ala Asn Ala Ile Leu Arg Arg Phe Leu Arg Glu Arg 115 120 125 gac aag ctt gcg gct tcc tgc aaa aaa gac gat gtg gcg aaa cac aac 432 Asp Lys Leu Ala Ala Ser Cys Lys Lys Asp Asp Val Ala Lys His Asn 130 135 140 ctg ccg ctg tgg tgg gtg gct tac ttg aaa aac cat tat ccg aaa cac 480 Leu Pro Leu Trp Trp Val Ala Tyr Leu Lys Asn His Tyr Pro Lys His 145 150 155 160 tgg cac aac atc gcc gcc gcg ctg caa tcc cat ccg ccg atg acg ttg 528 Trp His Asn Ile Ala Ala Ala Leu Gln Ser His Pro Pro Met Thr Leu 165 170 175 cgc gtc aac cgc cga cac ggc aac gcc gaa agc tat ttg gaa aaa ctg 576 Arg Val Asn Arg Arg His Gly Asn Ala Glu Ser Tyr Leu Glu Lys Leu 180 185 190 gct gcg gaa ggc att gcg gca aag gcg ttg gac gaa tat gcg gtt acg 624 Ala Ala Glu Gly Ile Ala Ala Lys Ala Leu Asp Glu Tyr Ala Val Thr 195 200 205 ttg gaa gaa gcc gtg ccg gtg aac cgc ctg ccc ggt ttt tca gac ggc 672 Leu Glu Glu Ala Val Pro Val Asn Arg Leu Pro Gly Phe Ser Asp Gly 210 215 220 att gtt tcg gta cag gac ttc ggc gcg cag cag gcg gcg tat ctc ctt 720 Ile Val Ser Val Gln Asp Phe Gly Ala Gln Gln Ala Ala Tyr Leu Leu 225 230 235 240 aac ccg aaa gac ggc gaa cgg att ttg gac gcg tgc gcc gcg ccg ggc 768 Asn Pro Lys Asp Gly Glu Arg Ile Leu Asp Ala Cys Ala Ala Pro Gly 245 250 255 ggc aag acg ggg cat atc ttg gaa ctg gcg gat tgc cgc gtt acc gcc 816 Gly Lys Thr Gly His Ile Leu Glu Leu Ala Asp Cys Arg Val Thr Ala 260 265 270 ttg gac att gat gca ggc cgt ctg aag cgt gtg gag gac aat atc gcc 864 Leu Asp Ile Asp Ala Gly Arg Leu Lys Arg Val Glu Asp Asn Ile Ala 275 280 285 cgt ttg ggc ttt cag acg gca tcg gcg gcg tgt gcc gat gcg cgg gat 912 Arg Leu Gly Phe Gln Thr Ala Ser Ala Ala Cys Ala Asp Ala Arg Asp 290 295 300 ttg gcg gcg tgg tat gat gga aag cct ttc gac aca atc ctt gcc gac 960 Leu Ala Ala Trp Tyr Asp Gly Lys Pro Phe Asp Thr Ile Leu Ala Asp 305 310 315 320 gtg cca tgc acc gct tcc ggc gtg gcg cgg cgc aat ccc gac gtg aaa 1008 Val Pro Cys Thr Ala Ser Gly Val Ala Arg Arg Asn Pro Asp Val Lys 325 330 335 tgg ctg cgc cgt ccg acc gac gcg ctc aaa acc gcc cgc cag cag gaa 1056 Trp Leu Arg Arg Pro Thr Asp Ala Leu Lys Thr Ala Arg Gln Gln Glu 340 345 350 gcc ctg ctg gac gca ctt tgg cag acg ctg aaa cag ggc ggc aga atg 1104 Ala Leu Leu Asp Ala Leu Trp Gln Thr Leu Lys Gln Gly Gly Arg Met 355 360 365 ctg ctt gcc acc tgt tcc gtg ttc gtc gaa gaa aac gac ggg caa ttg 1152 Leu Leu Ala Thr Cys Ser Val Phe Val Glu Glu Asn Asp Gly Gln Leu 370 375 380 caa aaa ttc ctc aac cgc cat gcc gat gcc gaa ccg atc gaa tcg cgg 1200 Gln Lys Phe Leu Asn Arg His Ala Asp Ala Glu Pro Ile Glu Ser Arg 385 390 395 400 gtg ctt tta ccg aac aaa cac caa gat ggc ttt tat tac gcg ctt att 1248 Val Leu Leu Pro Asn Lys His Gln Asp Gly Phe Tyr Tyr Ala Leu Ile 405 410 415 caa aag cat 1257 Gln Lys His <210> 168 <211> 419 <212> PRT <213> Neisseria meningitidis <400> 168 Met Ser Met Ala Leu Ala Gln Lys Leu Ala Ala Asp Ser Ile Ala Ala 1 5 10 15 Val Ala Glu Gly Arg Asn Leu Gln Asp Val Leu Ala Gln Ile Arg Thr 20 25 30 Ala His Pro Asp Leu Thr Ala Gln Glu Asn Gly Ala Leu Gln Asp Ile 35 40 45 Ala Tyr Gly Cys Gln Arg Tyr Leu Gly Ser Leu Lys His Met Leu Ala 50 55 60 Gln Met Leu Lys Lys Pro Ile Gly Asn Pro Gln Leu Glu Ser Leu Leu 65 70 75 80 Leu Ala Ala Leu Tyr Gln Leu His Tyr Thr Arg Asn Ala Pro His Ala 85 90 95 Val Val Asn Glu Ala Val Glu Ser Ile Ala Lys Ile Gly Arg Gly Gln 100 105 110 Tyr Arg Ser Phe Ala Asn Ala Ile Leu Arg Arg Phe Leu Arg Glu Arg 115 120 125 Asp Lys Leu Ala Ala Ser Cys Lys Lys Asp Asp Val Ala Lys His Asn 130 135 140 Leu Pro Leu Trp Trp Val Ala Tyr Leu Lys Asn His Tyr Pro Lys His 145 150 155 160 Trp His Asn Ile Ala Ala Ala Leu Gln Ser His Pro Pro Met Thr Leu 165 170 175 Arg Val Asn Arg Arg His Gly Asn Ala Glu Ser Tyr Leu Glu Lys Leu 180 185 190 Ala Ala Glu Gly Ile Ala Ala Lys Ala Leu Asp Glu Tyr Ala Val Thr 195 200 205 Leu Glu Glu Ala Val Pro Val Asn Arg Leu Pro Gly Phe Ser Asp Gly 210 215 220 Ile Val Ser Val Gln Asp Phe Gly Ala Gln Gln Ala Ala Tyr Leu Leu 225 230 235 240 Asn Pro Lys Asp Gly Glu Arg Ile Leu Asp Ala Cys Ala Ala Pro Gly 245 250 255 Gly Lys Thr Gly His Ile Leu Glu Leu Ala Asp Cys Arg Val Thr Ala 260 265 270 Leu Asp Ile Asp Ala Gly Arg Leu Lys Arg Val Glu Asp Asn Ile Ala 275 280 285 Arg Leu Gly Phe Gln Thr Ala Ser Ala Ala Cys Ala Asp Ala Arg Asp 290 295 300 Leu Ala Ala Trp Tyr Asp Gly Lys Pro Phe Asp Thr Ile Leu Ala Asp 305 310 315 320 Val Pro Cys Thr Ala Ser Gly Val Ala Arg Arg Asn Pro Asp Val Lys 325 330 335 Trp Leu Arg Arg Pro Thr Asp Ala Leu Lys Thr Ala Arg Gln Gln Glu 340 345 350 Ala Leu Leu Asp Ala Leu Trp Gln Thr Leu Lys Gln Gly Gly Arg Met 355 360 365 Leu Leu Ala Thr Cys Ser Val Phe Val Glu Glu Asn Asp Gly Gln Leu 370 375 380 Gln Lys Phe Leu Asn Arg His Ala Asp Ala Glu Pro Ile Glu Ser Arg 385 390 395 400 Val Leu Leu Pro Asn Lys His Gln Asp Gly Phe Tyr Tyr Ala Leu Ile 405 410 415 Gln Lys His <210> 169 <211> 804 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(804) <400> 169 atg aat atg aaa aaa tgg att gcc gcc gcc ctt gcc tgt tcc gcg ctc 48 Met Asn Met Lys Lys Trp Ile Ala Ala Ala Leu Ala Cys Ser Ala Leu 1 5 10 15 gcg ctg tct gcc tgc ggc ggt cag ggt aaa gat gcc gcc gcg ccc gcc 96 Ala Leu Ser Ala Cys Gly Gly Gln Gly Lys Asp Ala Ala Ala Pro Ala 20 25 30 gca aat ccc gac aaa gtg tac cgc gtg gct tcc aac gcc gag ttt gcc 144 Ala Asn Pro Asp Lys Val Tyr Arg Val Ala Ser Asn Ala Glu Phe Ala 35 40 45 ccc ttt gaa tct tta gac tcg aaa ggc aat gtc gaa ggt ttc gat gtg 192 Pro Phe Glu Ser Leu Asp Ser Lys Gly Asn Val Glu Gly Phe Asp Val 50 55 60 gat ttg atg aac gcg atg gcg aag gcg ggc aat ttt aaa atc gaa ttc 240 Asp Leu Met Asn Ala Met Ala Lys Ala Gly Asn Phe Lys Ile Glu Phe 65 70 75 80 aaa cac cag ccg tgg gac agc ctt ttc ccc gcc ttg aac aac ggc gat 288 Lys His Gln Pro Trp Asp Ser Leu Phe Pro Ala Leu Asn Asn Gly Asp 85 90 95 gcg gac gtt gtg atg tcg ggc gta acc att acc gac gac cgc aaa cag 336 Ala Asp Val Val Met Ser Gly Val Thr Ile Thr Asp Asp Arg Lys Gln 100 105 110 tct atg gac ttc agc gac ccg tat ttt gaa atc acc caa gtc gtc ctc 384 Ser Met Asp Phe Ser Asp Pro Tyr Phe Glu Ile Thr Gln Val Val Leu 115 120 125 gtt ccg aaa ggc aaa aaa ata tct tct tcc gaa gat ttg aaa aac atg 432 Val Pro Lys Gly Lys Lys Ile Ser Ser Ser Glu Asp Leu Lys Asn Met 130 135 140 aac aaa gtc ggc gtg gta acc ggc tac acg ggc gat ttc tcc gta tcc 480 Asn Lys Val Gly Val Val Thr Gly Tyr Thr Gly Asp Phe Ser Val Ser 145 150 155 160 aaa ctc ttg ggc aac gac aac ccg aaa atc gcg cgc ttt gaa aac gtt 528 Lys Leu Leu Gly Asn Asp Asn Pro Lys Ile Ala Arg Phe Glu Asn Val 165 170 175 ccc ctg att atc aaa gaa ctg gaa aac ggc ggc ttg gat tcc gtg gtc 576 Pro Leu Ile Ile Lys Glu Leu Glu Asn Gly Gly Leu Asp Ser Val Val 180 185 190 agc gac agc gca gtc atc gcc aat tat gtg aaa aac aat ccg acc aaa 624 Ser Asp Ser Ala Val Ile Ala Asn Tyr Val Lys Asn Asn Pro Thr Lys 195 200 205 ggg atg gac ttc gtt acc ctg ccc gac ttc acc acc gaa cac tac ggc 672 Gly Met Asp Phe Val Thr Leu Pro Asp Phe Thr Thr Glu His Tyr Gly 210 215 220 atc gcg gta cgc aaa ggc gac gaa gca acc gtc aaa atg ctg aac gat 720 Ile Ala Val Arg Lys Gly Asp Glu Ala Thr Val Lys Met Leu Asn Asp 225 230 235 240 gcg ttg aaa aaa gta cgc gaa agc ggc gaa tac gac aaa atc tac gcc 768 Ala Leu Lys Lys Val Arg Glu Ser Gly Glu Tyr Asp Lys Ile Tyr Ala 245 250 255 aaa tat ttt gca aaa gaa gac gga cag gcc gca aaa 804 Lys Tyr Phe Ala Lys Glu Asp Gly Gln Ala Ala Lys 260 265 <210> 170 <211> 268 <212> PRT <213> Neisseria meningitidis <400> 170 Met Asn Met Lys Lys Trp Ile Ala Ala Ala Leu Ala Cys Ser Ala Leu 1 5 10 15 Ala Leu Ser Ala Cys Gly Gly Gln Gly Lys Asp Ala Ala Ala Pro Ala 20 25 30 Ala Asn Pro Asp Lys Val Tyr Arg Val Ala Ser Asn Ala Glu Phe Ala 35 40 45 Pro Phe Glu Ser Leu Asp Ser Lys Gly Asn Val Glu Gly Phe Asp Val 50 55 60 Asp Leu Met Asn Ala Met Ala Lys Ala Gly Asn Phe Lys Ile Glu Phe 65 70 75 80 Lys His Gln Pro Trp Asp Ser Leu Phe Pro Ala Leu Asn Asn Gly Asp 85 90 95 Ala Asp Val Val Met Ser Gly Val Thr Ile Thr Asp Asp Arg Lys Gln 100 105 110 Ser Met Asp Phe Ser Asp Pro Tyr Phe Glu Ile Thr Gln Val Val Leu 115 120 125 Val Pro Lys Gly Lys Lys Ile Ser Ser Ser Glu Asp Leu Lys Asn Met 130 135 140 Asn Lys Val Gly Val Val Thr Gly Tyr Thr Gly Asp Phe Ser Val Ser 145 150 155 160 Lys Leu Leu Gly Asn Asp Asn Pro Lys Ile Ala Arg Phe Glu Asn Val 165 170 175 Pro Leu Ile Ile Lys Glu Leu Glu Asn Gly Gly Leu Asp Ser Val Val 180 185 190 Ser Asp Ser Ala Val Ile Ala Asn Tyr Val Lys Asn Asn Pro Thr Lys 195 200 205 Gly Met Asp Phe Val Thr Leu Pro Asp Phe Thr Thr Glu His Tyr Gly 210 215 220 Ile Ala Val Arg Lys Gly Asp Glu Ala Thr Val Lys Met Leu Asn Asp 225 230 235 240 Ala Leu Lys Lys Val Arg Glu Ser Gly Glu Tyr Asp Lys Ile Tyr Ala 245 250 255 Lys Tyr Phe Ala Lys Glu Asp Gly Gln Ala Ala Lys 260 265 <210> 171 <211> 864 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(864) <400> 171 atg aaa gca aaa atc ctg act tcc gtt gca ctg ctt gcc tgt tcc ggc 48 Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly 1 5 10 15 agc ctg ttt gcc caa acg ctg gca acc gtc aac ggt cag aaa atc gac 96 Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp 20 25 30 agt tcc gtc att gat gcg cag gtt gcc gca ttc cgt gcg gaa aac agc 144 Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser 35 40 45 cgt gcc gaa gac acg ccg caa ctg cgc caa tcc ctg ctg gaa aac gaa 192 Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu 50 55 60 gtg gtc aac acc gtg gtc gca cag gaa gtg aaa cgc ctg aaa ctc gac 240 Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp 65 70 75 80 cgg tcg gca gag ttt aaa aat gcg ctt gcc aaa ttg cgt gcc gaa gcg 288 Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala 85 90 95 aaa aag tcg ggc gac gac aag aaa ccg tcc ttc aaa acc gtt tgg cag 336 Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln 100 105 110 gcg gta aaa tat ggc ttg aac ggc gag gca tac gcg ctg cat atc gcc 384 Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala 115 120 125 aaa acc caa ccg gtt tcc gag cag gaa gta aaa gcc gca tat gac aat 432 Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn 130 135 140 atc agc ggt ttt tac aaa ggt acg cag gaa gtc cag ttg ggc gaa atc 480 Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile 145 150 155 160 ctg acc gac aag gaa gaa aat gca aaa aaa gcg gtt gcc gac ttg aag 528 Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys 165 170 175 gcg aaa aaa ggt ttc gat gcc gtc ttg aaa caa tat tcc ctc aac gac 576 Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp 180 185 190 cgt acc aaa cag acc ggt gcg ccg gtc gga tat gtg ccg ctg aaa gat 624 Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp 195 200 205 ttg gaa cag ggt gtt ccg ccg ctt tat cag gca att aag gac ttg aaa 672 Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys 210 215 220 aaa ggc gaa ttt acg gca acg ccg ctg aaa aac ggc gat ttc tac ggc 720 Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly 225 230 235 240 gtt tat tat gtc aac gac agc cgc gag gta aaa gtg cct tct ttt gat 768 Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp 245 250 255 gaa atg aaa gga cag att gcg ggc aac ctt cag gcg gaa cgg att gac 816 Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp 260 265 270 cgt gcc gtc ggt gca ctg ttg ggc aag gca aac atc aaa cct gca aaa 864 Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys 275 280 285 <210> 172 <211> 288 <212> PRT <213> Neisseria meningitidis <400> 172 Met Lys Ala Lys Ile Leu Thr Ser Val Ala Leu Leu Ala Cys Ser Gly 1 5 10 15 Ser Leu Phe Ala Gln Thr Leu Ala Thr Val Asn Gly Gln Lys Ile Asp 20 25 30 Ser Ser Val Ile Asp Ala Gln Val Ala Ala Phe Arg Ala Glu Asn Ser 35 40 45 Arg Ala Glu Asp Thr Pro Gln Leu Arg Gln Ser Leu Leu Glu Asn Glu 50 55 60 Val Val Asn Thr Val Val Ala Gln Glu Val Lys Arg Leu Lys Leu Asp 65 70 75 80 Arg Ser Ala Glu Phe Lys Asn Ala Leu Ala Lys Leu Arg Ala Glu Ala 85 90 95 Lys Lys Ser Gly Asp Asp Lys Lys Pro Ser Phe Lys Thr Val Trp Gln 100 105 110 Ala Val Lys Tyr Gly Leu Asn Gly Glu Ala Tyr Ala Leu His Ile Ala 115 120 125 Lys Thr Gln Pro Val Ser Glu Gln Glu Val Lys Ala Ala Tyr Asp Asn 130 135 140 Ile Ser Gly Phe Tyr Lys Gly Thr Gln Glu Val Gln Leu Gly Glu Ile 145 150 155 160 Leu Thr Asp Lys Glu Glu Asn Ala Lys Lys Ala Val Ala Asp Leu Lys 165 170 175 Ala Lys Lys Gly Phe Asp Ala Val Leu Lys Gln Tyr Ser Leu Asn Asp 180 185 190 Arg Thr Lys Gln Thr Gly Ala Pro Val Gly Tyr Val Pro Leu Lys Asp 195 200 205 Leu Glu Gln Gly Val Pro Pro Leu Tyr Gln Ala Ile Lys Asp Leu Lys 210 215 220 Lys Gly Glu Phe Thr Ala Thr Pro Leu Lys Asn Gly Asp Phe Tyr Gly 225 230 235 240 Val Tyr Tyr Val Asn Asp Ser Arg Glu Val Lys Val Pro Ser Phe Asp 245 250 255 Glu Met Lys Gly Gln Ile Ala Gly Asn Leu Gln Ala Glu Arg Ile Asp 260 265 270 Arg Ala Val Gly Ala Leu Leu Gly Lys Ala Asn Ile Lys Pro Ala Lys 275 280 285 <210> 173 <211> 1794 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1794) <400> 173 ttg ccc cga att gcc atg ccc tat ttc gcc ctg ttt gac gat gcc gta 48 Leu Pro Arg Ile Ala Met Pro Tyr Phe Ala Leu Phe Asp Asp Ala Val 1 5 10 15 agc ggt cgc gca aaa cgc tat caa aat cat gtg gaa agc cgt ttt ttc 96 Ser Gly Arg Ala Lys Arg Tyr Gln Asn His Val Glu Ser Arg Phe Phe 20 25 30 cgt ccc gaa gaa ctc gat gct ttg gac ggc gcg ctg caa tcg ggc tgg 144 Arg Pro Glu Glu Leu Asp Ala Leu Asp Gly Ala Leu Gln Ser Gly Trp 35 40 45 caa aaa ggg ctg cat gcc gtg ttg ttt gca gac tac gga ttc ggt ttg 192 Gln Lys Gly Leu His Ala Val Leu Phe Ala Asp Tyr Gly Phe Gly Leu 50 55 60 ccg ctg acg ggg gtc gag tcc gaa cgc ggc ggc aac ctt gcc ctg cac 240 Pro Leu Thr Gly Val Glu Ser Glu Arg Gly Gly Asn Leu Ala Leu His 65 70 75 80 tgg ttt gcc gac tgc gcc gac acc gat gcc gca agc tgg ctt gcc cga 288 Trp Phe Ala Asp Cys Ala Asp Thr Asp Ala Ala Ser Trp Leu Ala Arg 85 90 95 cac tca gac ggc ctc ccc gcc ggc att tcc acg ccg caa tcc tcc gta 336 His Ser Asp Gly Leu Pro Ala Gly Ile Ser Thr Pro Gln Ser Ser Val 100 105 110 tcc gaa gcc gat tac ctc gac cat atc cgc caa atc cac gaa gcc atc 384 Ser Glu Ala Asp Tyr Leu Asp His Ile Arg Gln Ile His Glu Ala Ile 115 120 125 cga cgc ggc gac acc tat caa atc aac tac act acc cgc ctg cac ctg 432 Arg Arg Gly Asp Thr Tyr Gln Ile Asn Tyr Thr Thr Arg Leu His Leu 130 135 140 caa gcc tac ggc aat ccc gtc aaa ctt tac caa cgc ctg cgc cag ccc 480 Gln Ala Tyr Gly Asn Pro Val Lys Leu Tyr Gln Arg Leu Arg Gln Pro 145 150 155 160 gtc ccc tat gcc gtt ttg tcc cac ctg ccc gat gca caa ggg caa tcc 528 Val Pro Tyr Ala Val Leu Ser His Leu Pro Asp Ala Gln Gly Gln Ser 165 170 175 gcg tgg acg ctg tgt ttc tcg ccc gaa ctc ttc ctc aaa atc ggt tcg 576 Ala Trp Thr Leu Cys Phe Ser Pro Glu Leu Phe Leu Lys Ile Gly Ser 180 185 190 gac ggc acc atc agc acc gaa ccg atg aaa ggc acc gcg ccg att ttg 624 Asp Gly Thr Ile Ser Thr Glu Pro Met Lys Gly Thr Ala Pro Ile Leu 195 200 205 ggc gac gga caa gac gaa cgc cgc gcc gcc gag ttg caa gca gac ccg 672 Gly Asp Gly Gln Asp Glu Arg Arg Ala Ala Glu Leu Gln Ala Asp Pro 210 215 220 aaa aac cgc gcc gaa aac gtg atg att gtc gat ttg ctg cgt aac gac 720 Lys Asn Arg Ala Glu Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp 225 230 235 240 ctc ggc aaa atc gcc caa acc ggc aca gta tgc gta ccc gaa ccg ttt 768 Leu Gly Lys Ile Ala Gln Thr Gly Thr Val Cys Val Pro Glu Pro Phe 245 250 255 aaa gta tcg cgt ttc ggc agc gtt tgg cag atg acc agc acc atc caa 816 Lys Val Ser Arg Phe Gly Ser Val Trp Gln Met Thr Ser Thr Ile Gln 260 265 270 gcc caa gcc ttg ccg cac acc tcg ttc gcc gac atc ctc cgc gcc gcc 864 Ala Gln Ala Leu Pro His Thr Ser Phe Ala Asp Ile Leu Arg Ala Ala 275 280 285 ttc ccc tgc ggc agc atc acc ggc gcg ccc aaa aaa atg agt atg cag 912 Phe Pro Cys Gly Ser Ile Thr Gly Ala Pro Lys Lys Met Ser Met Gln 290 295 300 att atc gaa tcg ctc gaa gcc gaa gcg cgc gga ctt tat acg ggc agc 960 Ile Ile Glu Ser Leu Glu Ala Glu Ala Arg Gly Leu Tyr Thr Gly Ser 305 310 315 320 atc ggc tat ttg aac ccg tgt tcc ggc ggc ttg ggg ttt gaa ggc acg 1008 Ile Gly Tyr Leu Asn Pro Cys Ser Gly Gly Leu Gly Phe Glu Gly Thr 325 330 335 ttc aac gtc gtt atc cgc acc ttg tcg ctc acg ccg ctt tca gac ggc 1056 Phe Asn Val Val Ile Arg Thr Leu Ser Leu Thr Pro Leu Ser Asp Gly 340 345 350 att tat caa ggc gtg tac ggt gtc ggt tcc ggc atc gtc atc gac agc 1104 Ile Tyr Gln Gly Val Tyr Gly Val Gly Ser Gly Ile Val Ile Asp Ser 355 360 365 gac cct gcc gcc gaa tat cgg gaa tgc ggc tgg aaa gcc cgt ttc ctc 1152 Asp Pro Ala Ala Glu Tyr Arg Glu Cys Gly Trp Lys Ala Arg Phe Leu 370 375 380 aac gaa ttg cgc ccc gac ttc ggc att ttt gaa acc ctg cgc gtg gaa 1200 Asn Glu Leu Arg Pro Asp Phe Gly Ile Phe Glu Thr Leu Arg Val Glu 385 390 395 400 aac gga cgc tgc gcc ctg ctc gac cgc cac cta tgc cgt ctg aaa acc 1248 Asn Gly Arg Cys Ala Leu Leu Asp Arg His Leu Cys Arg Leu Lys Thr 405 410 415 tcc gcc caa gcc ctc aac ctg ccc ctg ccc gac ggt tgc gaa aat caa 1296 Ser Ala Gln Ala Leu Asn Leu Pro Leu Pro Asp Gly Cys Glu Asn Gln 420 425 430 atc aaa caa tac atc gca cgc ttg ccc gac ggc gcg ttc cgc atc aaa 1344 Ile Lys Gln Tyr Ile Ala Arg Leu Pro Asp Gly Ala Phe Arg Ile Lys 435 440 445 gcc ctg ctc gct tca gac ggc atc agc ctg tcc cgc gcc gtt tta aac 1392 Ala Leu Leu Ala Ser Asp Gly Ile Ser Leu Ser Arg Ala Val Leu Asn 450 455 460 cgt ctg acc gac aaa caa cgc gtc atc att tcg ccg acc atc ctg ccc 1440 Arg Leu Thr Asp Lys Gln Arg Val Ile Ile Ser Pro Thr Ile Leu Pro 465 470 475 480 gca caa aac tac ctg cgc cgc ttc aaa acc acc tgc cgc acc gtc ttc 1488 Ala Gln Asn Tyr Leu Arg Arg Phe Lys Thr Thr Cys Arg Thr Val Phe 485 490 495 gac caa gcg tgg caa acc gcc gaa aca caa ggc gcg ttc gac agc ctg 1536 Asp Gln Ala Trp Gln Thr Ala Glu Thr Gln Gly Ala Phe Asp Ser Leu 500 505 510 ttt ttc aat tca gac ggc atc ctg ctc gaa ggc ggc aga agc aac gtg 1584 Phe Phe Asn Ser Asp Gly Ile Leu Leu Glu Gly Gly Arg Ser Asn Val 515 520 525 ttc gtc aaa cat cgc gga caa tgg ctc acg ccc tct tta gat tta gac 1632 Phe Val Lys His Arg Gly Gln Trp Leu Thr Pro Ser Leu Asp Leu Asp 530 535 540 att tta aac ggc ata atg cgc caa gcc gtg ttg gac gaa ccg caa aaa 1680 Ile Leu Asn Gly Ile Met Arg Gln Ala Val Leu Asp Glu Pro Gln Lys 545 550 555 560 tat ttg caa aca aat caa gta atc gaa aca cac atc aca caa aaa aca 1728 Tyr Leu Gln Thr Asn Gln Val Ile Glu Thr His Ile Thr Gln Lys Thr 565 570 575 ctg caa gaa gcc gaa gaa atc cgc ctc tcc aac gcc ttg cgc ggc gta 1776 Leu Gln Glu Ala Glu Glu Ile Arg Leu Ser Asn Ala Leu Arg Gly Val 580 585 590 ttt gcc gcc gcc ctt gcc 1794 Phe Ala Ala Ala Leu Ala 595 <210> 174 <211> 598 <212> PRT <213> Neisseria meningitidis <400> 174 Leu Pro Arg Ile Ala Met Pro Tyr Phe Ala Leu Phe Asp Asp Ala Val 1 5 10 15 Ser Gly Arg Ala Lys Arg Tyr Gln Asn His Val Glu Ser Arg Phe Phe 20 25 30 Arg Pro Glu Glu Leu Asp Ala Leu Asp Gly Ala Leu Gln Ser Gly Trp 35 40 45 Gln Lys Gly Leu His Ala Val Leu Phe Ala Asp Tyr Gly Phe Gly Leu 50 55 60 Pro Leu Thr Gly Val Glu Ser Glu Arg Gly Gly Asn Leu Ala Leu His 65 70 75 80 Trp Phe Ala Asp Cys Ala Asp Thr Asp Ala Ala Ser Trp Leu Ala Arg 85 90 95 His Ser Asp Gly Leu Pro Ala Gly Ile Ser Thr Pro Gln Ser Ser Val 100 105 110 Ser Glu Ala Asp Tyr Leu Asp His Ile Arg Gln Ile His Glu Ala Ile 115 120 125 Arg Arg Gly Asp Thr Tyr Gln Ile Asn Tyr Thr Thr Arg Leu His Leu 130 135 140 Gln Ala Tyr Gly Asn Pro Val Lys Leu Tyr Gln Arg Leu Arg Gln Pro 145 150 155 160 Val Pro Tyr Ala Val Leu Ser His Leu Pro Asp Ala Gln Gly Gln Ser 165 170 175 Ala Trp Thr Leu Cys Phe Ser Pro Glu Leu Phe Leu Lys Ile Gly Ser 180 185 190 Asp Gly Thr Ile Ser Thr Glu Pro Met Lys Gly Thr Ala Pro Ile Leu 195 200 205 Gly Asp Gly Gln Asp Glu Arg Arg Ala Ala Glu Leu Gln Ala Asp Pro 210 215 220 Lys Asn Arg Ala Glu Asn Val Met Ile Val Asp Leu Leu Arg Asn Asp 225 230 235 240 Leu Gly Lys Ile Ala Gln Thr Gly Thr Val Cys Val Pro Glu Pro Phe 245 250 255 Lys Val Ser Arg Phe Gly Ser Val Trp Gln Met Thr Ser Thr Ile Gln 260 265 270 Ala Gln Ala Leu Pro His Thr Ser Phe Ala Asp Ile Leu Arg Ala Ala 275 280 285 Phe Pro Cys Gly Ser Ile Thr Gly Ala Pro Lys Lys Met Ser Met Gln 290 295 300 Ile Ile Glu Ser Leu Glu Ala Glu Ala Arg Gly Leu Tyr Thr Gly Ser 305 310 315 320 Ile Gly Tyr Leu Asn Pro Cys Ser Gly Gly Leu Gly Phe Glu Gly Thr 325 330 335 Phe Asn Val Val Ile Arg Thr Leu Ser Leu Thr Pro Leu Ser Asp Gly 340 345 350 Ile Tyr Gln Gly Val Tyr Gly Val Gly Ser Gly Ile Val Ile Asp Ser 355 360 365 Asp Pro Ala Ala Glu Tyr Arg Glu Cys Gly Trp Lys Ala Arg Phe Leu 370 375 380 Asn Glu Leu Arg Pro Asp Phe Gly Ile Phe Glu Thr Leu Arg Val Glu 385 390 395 400 Asn Gly Arg Cys Ala Leu Leu Asp Arg His Leu Cys Arg Leu Lys Thr 405 410 415 Ser Ala Gln Ala Leu Asn Leu Pro Leu Pro Asp Gly Cys Glu Asn Gln 420 425 430 Ile Lys Gln Tyr Ile Ala Arg Leu Pro Asp Gly Ala Phe Arg Ile Lys 435 440 445 Ala Leu Leu Ala Ser Asp Gly Ile Ser Leu Ser Arg Ala Val Leu Asn 450 455 460 Arg Leu Thr Asp Lys Gln Arg Val Ile Ile Ser Pro Thr Ile Leu Pro 465 470 475 480 Ala Gln Asn Tyr Leu Arg Arg Phe Lys Thr Thr Cys Arg Thr Val Phe 485 490 495 Asp Gln Ala Trp Gln Thr Ala Glu Thr Gln Gly Ala Phe Asp Ser Leu 500 505 510 Phe Phe Asn Ser Asp Gly Ile Leu Leu Glu Gly Gly Arg Ser Asn Val 515 520 525 Phe Val Lys His Arg Gly Gln Trp Leu Thr Pro Ser Leu Asp Leu Asp 530 535 540 Ile Leu Asn Gly Ile Met Arg Gln Ala Val Leu Asp Glu Pro Gln Lys 545 550 555 560 Tyr Leu Gln Thr Asn Gln Val Ile Glu Thr His Ile Thr Gln Lys Thr 565 570 575 Leu Gln Glu Ala Glu Glu Ile Arg Leu Ser Asn Ala Leu Arg Gly Val 580 585 590 Phe Ala Ala Ala Leu Ala 595 <210> 175 <211> 279 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(279) <400> 175 ttg caa aac ttt cgg aaa ccc aat atg cag acc gtt acc atg tac aca 48 Leu Gln Asn Phe Arg Lys Pro Asn Met Gln Thr Val Thr Met Tyr Thr 1 5 10 15 ggt ccg ttt tgc ccc tac tgc acg atg gcg aaa agg ctg ctg cac gcg 96 Gly Pro Phe Cys Pro Tyr Cys Thr Met Ala Lys Arg Leu Leu His Ala 20 25 30 gca ggt gtc gga cat atc gac gaa atc cgt gtc gat gca agt ccc gaa 144 Ala Gly Val Gly His Ile Asp Glu Ile Arg Val Asp Ala Ser Pro Glu 35 40 45 gcc ttt gcc gaa atg cag cag ctt tcc gga cag cgc agc gtg ccg cag 192 Ala Phe Ala Glu Met Gln Gln Leu Ser Gly Gln Arg Ser Val Pro Gln 50 55 60 att ttc atc ggc gaa acg cac gtc ggc gga ttt acc gac ctc tac cgc 240 Ile Phe Ile Gly Glu Thr His Val Gly Gly Phe Thr Asp Leu Tyr Arg 65 70 75 80 ctc cag cag gaa ggc ggg ctg gac gga ctg ctg aac cct 279 Leu Gln Gln Glu Gly Gly Leu Asp Gly Leu Leu Asn Pro 85 90 <210> 176 <211> 93 <212> PRT <213> Neisseria meningitidis <400> 176 Leu Gln Asn Phe Arg Lys Pro Asn Met Gln Thr Val Thr Met Tyr Thr 1 5 10 15 Gly Pro Phe Cys Pro Tyr Cys Thr Met Ala Lys Arg Leu Leu His Ala 20 25 30 Ala Gly Val Gly His Ile Asp Glu Ile Arg Val Asp Ala Ser Pro Glu 35 40 45 Ala Phe Ala Glu Met Gln Gln Leu Ser Gly Gln Arg Ser Val Pro Gln 50 55 60 Ile Phe Ile Gly Glu Thr His Val Gly Gly Phe Thr Asp Leu Tyr Arg 65 70 75 80 Leu Gln Gln Glu Gly Gly Leu Asp Gly Leu Leu Asn Pro 85 90 <210> 177 <211> 2274 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2274) <400> 177 atg aca aca tta cat ttc tca ggc ttc ccg cgt gtc ggt gcc ttc cgc 48 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 gaa ttg aaa ttc gca caa gaa aaa tac tgg cgc aaa gaa atc agc gag 96 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 caa gaa ttg ctg gct gtt gct aaa gac ttg cgc gag aaa aac tgg aaa 144 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 cac cag gcc gct gcc aac gcc gat tac gtt gcc gta ggc gat ttc act 192 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 ttc tac gac cac atc ctc gac ctg caa gtc gcc acc ggc gcg att ccc 240 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 gcc cgc ttc ggc ttc gac agc caa aac cta tct ttg gaa caa ttc ttc 288 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 caa ctg gcg cgc ggt aac aaa gac caa ttc gct atc gaa atg acc aaa 336 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 tgg ttc gac acc aac tac cac tac ttg gtg cct gaa ttc cac gcc gat 384 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 acc gaa ttt aaa gcc aat gcc aaa cac tac gtt caa cag ctg caa gaa 432 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 gcc caa gct ttg ggc ctg aaa gcc aaa ccg acc gtt gtg ggt ccg ttg 480 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 act ttc ctg tgg gtc ggt aaa gaa aaa ggc gcc gtt gaa ttc gac cgt 528 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 ctg agc ctg ttg cct aaa ctg ttg cct gtt tac gtt gaa atc ctg act 576 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 gct ttg gtt gaa gcc ggt gcc gag tgg att caa atc gac gag cct gct 624 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 ttg act gtt gac ctg cct aaa gaa tgg gta gaa gca tac aaa gac gtt 672 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 tac gcc act ttg agc aaa gta agt gcc aaa atc ctg ctg agc act tac 720 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 ttc ggt tct gtt gcc gaa cac gcc gca ttg ttg aaa tcc ctg cct gtt 768 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 gac ggc ctg cac atc gac ttg gta cgc gct cct gaa caa ctg gat gcg 816 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 ttc gcc gac tac gac aaa gtt ctg tct gcc ggc gtc att gac ggc cgc 864 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 aat att tgg cgc gcc aac ctg aac aaa gtt ttg gaa act gtt gag ctt 912 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 ctg caa gcc aaa ctg ggc gac cgt ttg tgg att tcc agc tct tgc tcg 960 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 ctg ctg cac act ccg ttt gac ttg tca gtt gaa gaa aaa ctg aaa gcc 1008 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 aac aaa ccc gac ctg tac tct tgg ttg gca ttc acc ctg caa aaa acc 1056 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 caa gaa ttg cgc gtc ctg aaa gcc gca ttg aac gaa ggc cgt gat tct 1104 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 gtt gcc gaa gaa ctg gct gcc agc caa gct gct gcc gac tcc cgt gcc 1152 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 aac agc agc gaa atc cac cgt gca gac gtt gcc aaa cgc ctg gcc gat 1200 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 ttg cct gcc aac gca gac caa cgc aaa tcc cca ttt gcc gac cgt atc 1248 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 aaa gcg caa caa gca tgg ttg aac ctg cct ctg ctg ccg acg acc aac 1296 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 atc ggt tct ttc ccg caa act acc gaa atc cgc caa gca cgc gca gcc 1344 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 ttc aaa aaa ggc gaa ctg tct gcc gcc gat tac gaa gcc gcg atg aaa 1392 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 aaa gaa atc gcc ttg gtg gtt gaa gag caa gaa aaa ctg gac ttg gac 1440 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 gta ctg gta cac ggc gaa gcc gag cgt aac gac atg gtt gaa tac ttc 1488 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 ggc gaa ttg ttg agc ggt ttt gca ttc acc caa tat ggc tgg gta caa 1536 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 agc tac ggt tct cgc tgc gtt aaa cca ccg att atc ttc ggt gac gta 1584 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 agc cgt cct gaa gcc atg acc gta gct tgg tct act tac gca caa agc 1632 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 ctg acc aaa cgc ccg atg aaa ggt atg ttg acc ggc cct gta acc att 1680 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 ctg caa tgg tct ttc gtc cgc aac gat att cct cgc tct acc gtg tgt 1728 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 aaa caa atc gca ctg gct ctg aac gac gaa gta ttg gat ctg gaa aaa 1776 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 gca ggc atc aaa gtc atc caa atc gac gaa cct gcc atc cgc gaa ggc 1824 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 ctg cct ttg aaa cgt gcc gat tgg gat gcc tac ctg aac tgg gcc ggc 1872 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 gaa tct ttc cgc ctg tcc tct acc ggt tgc gaa gac agc act caa atc 1920 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 cac acc cat atg tgc tac tct gag ttc aac gac atc ctg cct gcg att 1968 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 gct gca atg gat gcg gac gtg atc acc atc gag act tca cgt tcc gac 2016 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 atg gaa ctc ttg acc gcg ttc ggc gaa ttc aaa tac ccg aac gac atc 2064 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 ggc ccg ggg gtt tac gac atc cac agc ccg cgc gta ccg aca gaa gcc 2112 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 gaa gtg gag cac ctg ttg cgc aaa gcc atc gag gtt gta ccg gtt gaa 2160 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 cgt ctg tgg gtt aac ccg gac tgc ggc ctg aaa aca cgc ggc tgg aaa 2208 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 gaa act ctg gaa caa ctc caa gtg atg atg aac gta acc cac aaa ttg 2256 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 cgt gcc gaa ttg gcg aaa 2274 Arg Ala Glu Leu Ala Lys 755 <210> 178 <211> 758 <212> PRT <213> Neisseria meningitidis <400> 178 Met Thr Thr Leu His Phe Ser Gly Phe Pro Arg Val Gly Ala Phe Arg 1 5 10 15 Glu Leu Lys Phe Ala Gln Glu Lys Tyr Trp Arg Lys Glu Ile Ser Glu 20 25 30 Gln Glu Leu Leu Ala Val Ala Lys Asp Leu Arg Glu Lys Asn Trp Lys 35 40 45 His Gln Ala Ala Ala Asn Ala Asp Tyr Val Ala Val Gly Asp Phe Thr 50 55 60 Phe Tyr Asp His Ile Leu Asp Leu Gln Val Ala Thr Gly Ala Ile Pro 65 70 75 80 Ala Arg Phe Gly Phe Asp Ser Gln Asn Leu Ser Leu Glu Gln Phe Phe 85 90 95 Gln Leu Ala Arg Gly Asn Lys Asp Gln Phe Ala Ile Glu Met Thr Lys 100 105 110 Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Phe His Ala Asp 115 120 125 Thr Glu Phe Lys Ala Asn Ala Lys His Tyr Val Gln Gln Leu Gln Glu 130 135 140 Ala Gln Ala Leu Gly Leu Lys Ala Lys Pro Thr Val Val Gly Pro Leu 145 150 155 160 Thr Phe Leu Trp Val Gly Lys Glu Lys Gly Ala Val Glu Phe Asp Arg 165 170 175 Leu Ser Leu Leu Pro Lys Leu Leu Pro Val Tyr Val Glu Ile Leu Thr 180 185 190 Ala Leu Val Glu Ala Gly Ala Glu Trp Ile Gln Ile Asp Glu Pro Ala 195 200 205 Leu Thr Val Asp Leu Pro Lys Glu Trp Val Glu Ala Tyr Lys Asp Val 210 215 220 Tyr Ala Thr Leu Ser Lys Val Ser Ala Lys Ile Leu Leu Ser Thr Tyr 225 230 235 240 Phe Gly Ser Val Ala Glu His Ala Ala Leu Leu Lys Ser Leu Pro Val 245 250 255 Asp Gly Leu His Ile Asp Leu Val Arg Ala Pro Glu Gln Leu Asp Ala 260 265 270 Phe Ala Asp Tyr Asp Lys Val Leu Ser Ala Gly Val Ile Asp Gly Arg 275 280 285 Asn Ile Trp Arg Ala Asn Leu Asn Lys Val Leu Glu Thr Val Glu Leu 290 295 300 Leu Gln Ala Lys Leu Gly Asp Arg Leu Trp Ile Ser Ser Ser Cys Ser 305 310 315 320 Leu Leu His Thr Pro Phe Asp Leu Ser Val Glu Glu Lys Leu Lys Ala 325 330 335 Asn Lys Pro Asp Leu Tyr Ser Trp Leu Ala Phe Thr Leu Gln Lys Thr 340 345 350 Gln Glu Leu Arg Val Leu Lys Ala Ala Leu Asn Glu Gly Arg Asp Ser 355 360 365 Val Ala Glu Glu Leu Ala Ala Ser Gln Ala Ala Ala Asp Ser Arg Ala 370 375 380 Asn Ser Ser Glu Ile His Arg Ala Asp Val Ala Lys Arg Leu Ala Asp 385 390 395 400 Leu Pro Ala Asn Ala Asp Gln Arg Lys Ser Pro Phe Ala Asp Arg Ile 405 410 415 Lys Ala Gln Gln Ala Trp Leu Asn Leu Pro Leu Leu Pro Thr Thr Asn 420 425 430 Ile Gly Ser Phe Pro Gln Thr Thr Glu Ile Arg Gln Ala Arg Ala Ala 435 440 445 Phe Lys Lys Gly Glu Leu Ser Ala Ala Asp Tyr Glu Ala Ala Met Lys 450 455 460 Lys Glu Ile Ala Leu Val Val Glu Glu Gln Glu Lys Leu Asp Leu Asp 465 470 475 480 Val Leu Val His Gly Glu Ala Glu Arg Asn Asp Met Val Glu Tyr Phe 485 490 495 Gly Glu Leu Leu Ser Gly Phe Ala Phe Thr Gln Tyr Gly Trp Val Gln 500 505 510 Ser Tyr Gly Ser Arg Cys Val Lys Pro Pro Ile Ile Phe Gly Asp Val 515 520 525 Ser Arg Pro Glu Ala Met Thr Val Ala Trp Ser Thr Tyr Ala Gln Ser 530 535 540 Leu Thr Lys Arg Pro Met Lys Gly Met Leu Thr Gly Pro Val Thr Ile 545 550 555 560 Leu Gln Trp Ser Phe Val Arg Asn Asp Ile Pro Arg Ser Thr Val Cys 565 570 575 Lys Gln Ile Ala Leu Ala Leu Asn Asp Glu Val Leu Asp Leu Glu Lys 580 585 590 Ala Gly Ile Lys Val Ile Gln Ile Asp Glu Pro Ala Ile Arg Glu Gly 595 600 605 Leu Pro Leu Lys Arg Ala Asp Trp Asp Ala Tyr Leu Asn Trp Ala Gly 610 615 620 Glu Ser Phe Arg Leu Ser Ser Thr Gly Cys Glu Asp Ser Thr Gln Ile 625 630 635 640 His Thr His Met Cys Tyr Ser Glu Phe Asn Asp Ile Leu Pro Ala Ile 645 650 655 Ala Ala Met Asp Ala Asp Val Ile Thr Ile Glu Thr Ser Arg Ser Asp 660 665 670 Met Glu Leu Leu Thr Ala Phe Gly Glu Phe Lys Tyr Pro Asn Asp Ile 675 680 685 Gly Pro Gly Val Tyr Asp Ile His Ser Pro Arg Val Pro Thr Glu Ala 690 695 700 Glu Val Glu His Leu Leu Arg Lys Ala Ile Glu Val Val Pro Val Glu 705 710 715 720 Arg Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Lys 725 730 735 Glu Thr Leu Glu Gln Leu Gln Val Met Met Asn Val Thr His Lys Leu 740 745 750 Arg Ala Glu Leu Ala Lys 755 <210> 179 <211> 867 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(867) <400> 179 atg aaa ccc ata cgg aaa gcc gtc ttc ccc gtc gca ggg atg gga aca 48 Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr 1 5 10 15 cgc ttc ctg ccc gcc acc aag gca agc ccg aaa gaa atg ctg ccc atc 96 Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile 20 25 30 gtc gac aag ccg ctg atc caa tac gcc gta gaa gaa gcc gtg gaa gcc 144 Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala 35 40 45 ggc tgc acg gaa atg gtg ttt gtt acc gga cgc aac aaa cgc agc atc 192 Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile 50 55 60 gaa gac cat ttc gac aag gca tac gaa ctc gaa acc gag ttg gaa atg 240 Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met 65 70 75 80 cgc cat aaa gac aaa ttg ttg gaa cac gtc cgc aac atc ctg ccg ccg 288 Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro 85 90 95 aac att acc tgc ctc tac atc cgt cag gcg gaa gca ctg ggc ttg gga 336 Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly 100 105 110 cac gcc gtc ttg tgc gcc cgc gcc gcc atc ggc gac gaa ccc ttt gcc 384 His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala 115 120 125 gtg att ttg gct gac gat tta atc gat gcc caa aaa ggc gcg ctc aaa 432 Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys 130 135 140 caa atg gtc gaa gtg tac gaa cgc agc ggc aac agc att ttg ggc gta 480 Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val 145 150 155 160 gaa act gtc gaa ccg tcg caa acc ggc tca tac ggc atc gtc gaa acc 528 Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr 165 170 175 gaa cag ctc aaa cag ttc caa cgc att acc ggc att gtc gaa aaa ccc 576 Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro 180 185 190 aag ccc gaa gac gcg ccc tcc aac ctt gcc gtc gtc gga cgc tac atc 624 Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile 195 200 205 ctt acc ccg cgc att ttc gac tta ctg acc gga ctg ccg cgc ggc gcg 672 Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala 210 215 220 ggc aac gaa atc cag ctt aca gac ggc atc gcc aag ctg ctc gat cac 720 Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His 225 230 235 240 gaa ttt gtc cta gcg cac ccc ttt gaa ggc acg cgc tac gac tgc ggc 768 Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly 245 250 255 agc aaa ctg ggc tat ctg gaa gcc acc gtc gcc tac ggc ctg aaa cac 816 Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His 260 265 270 ccc gaa acc ggc gaa ccc ttc cgc cgc ctt ttg gaa aaa tac cgt acc 864 Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr 275 280 285 gaa 867 Glu <210> 180 <211> 289 <212> PRT <213> Neisseria meningitidis <400> 180 Met Lys Pro Ile Arg Lys Ala Val Phe Pro Val Ala Gly Met Gly Thr 1 5 10 15 Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro Ile 20 25 30 Val Asp Lys Pro Leu Ile Gln Tyr Ala Val Glu Glu Ala Val Glu Ala 35 40 45 Gly Cys Thr Glu Met Val Phe Val Thr Gly Arg Asn Lys Arg Ser Ile 50 55 60 Glu Asp His Phe Asp Lys Ala Tyr Glu Leu Glu Thr Glu Leu Glu Met 65 70 75 80 Arg His Lys Asp Lys Leu Leu Glu His Val Arg Asn Ile Leu Pro Pro 85 90 95 Asn Ile Thr Cys Leu Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu Gly 100 105 110 His Ala Val Leu Cys Ala Arg Ala Ala Ile Gly Asp Glu Pro Phe Ala 115 120 125 Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Gln Lys Gly Ala Leu Lys 130 135 140 Gln Met Val Glu Val Tyr Glu Arg Ser Gly Asn Ser Ile Leu Gly Val 145 150 155 160 Glu Thr Val Glu Pro Ser Gln Thr Gly Ser Tyr Gly Ile Val Glu Thr 165 170 175 Glu Gln Leu Lys Gln Phe Gln Arg Ile Thr Gly Ile Val Glu Lys Pro 180 185 190 Lys Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly Arg Tyr Ile 195 200 205 Leu Thr Pro Arg Ile Phe Asp Leu Leu Thr Gly Leu Pro Arg Gly Ala 210 215 220 Gly Asn Glu Ile Gln Leu Thr Asp Gly Ile Ala Lys Leu Leu Asp His 225 230 235 240 Glu Phe Val Leu Ala His Pro Phe Glu Gly Thr Arg Tyr Asp Cys Gly 245 250 255 Ser Lys Leu Gly Tyr Leu Glu Ala Thr Val Ala Tyr Gly Leu Lys His 260 265 270 Pro Glu Thr Gly Glu Pro Phe Arg Arg Leu Leu Glu Lys Tyr Arg Thr 275 280 285 Glu <210> 181 <211> 603 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(603) <400> 181 atg aca ata atg aat atc aat act tcc gaa aat aaa gat gct gtt gcc 48 Met Thr Ile Met Asn Ile Asn Thr Ser Glu Asn Lys Asp Ala Val Ala 1 5 10 15 gaa cac acc gga caa tgg ttg gaa aaa gcc gtc atc ggt ctg aac ctg 96 Glu His Thr Gly Gln Trp Leu Glu Lys Ala Val Ile Gly Leu Asn Leu 20 25 30 tgt ccc ttt gcc aaa gcc ccc cac gtt aaa aac ctt gtc cgc atc gca 144 Cys Pro Phe Ala Lys Ala Pro His Val Lys Asn Leu Val Arg Ile Ala 35 40 45 atc agc gaa gcc aaa cac ctt gac agt ttt ttg gaa gac ttg gac gaa 192 Ile Ser Glu Ala Lys His Leu Asp Ser Phe Leu Glu Asp Leu Asp Glu 50 55 60 gaa ctg cag cga ctg ggc aat aca ccc gcc acc gaa ctg gaa act acc 240 Glu Leu Gln Arg Leu Gly Asn Thr Pro Ala Thr Glu Leu Glu Thr Thr 65 70 75 80 ctg ctg gtt cac ccg acc cta ttc ccc gat ttc gac gta ttc aac gat 288 Leu Leu Val His Pro Thr Leu Phe Pro Asp Phe Asp Val Phe Asn Asp 85 90 95 atg ctc gac att gcc gat gcc gcc gtt gtc gaa aac ggc ttg gaa ggc 336 Met Leu Asp Ile Ala Asp Ala Ala Val Val Glu Asn Gly Leu Glu Gly 100 105 110 atc atc caa atc gcc ccg ttt cat ccc gat ttc caa ttt gaa ggc acg 384 Ile Ile Gln Ile Ala Pro Phe His Pro Asp Phe Gln Phe Glu Gly Thr 115 120 125 gat tca gac gac atc ggc aac tac acc aac cgt tct ccc tat ccg acg 432 Asp Ser Asp Asp Ile Gly Asn Tyr Thr Asn Arg Ser Pro Tyr Pro Thr 130 135 140 ctg cac ctc atc cgc gaa gac agc att gcc aaa gcc gca caa gcc ttt 480 Leu His Leu Ile Arg Glu Asp Ser Ile Ala Lys Ala Ala Gln Ala Phe 145 150 155 160 ccc gac gct tcg gca ata ttc gaa cgc aat atc gcc ctg ctg gaa aaa 528 Pro Asp Ala Ser Ala Ile Phe Glu Arg Asn Ile Ala Leu Leu Glu Lys 165 170 175 atg gga cat gag ggc tgg gca aaa ctc ggt atc aca tcc tgc cct tat 576 Met Gly His Glu Gly Trp Ala Lys Leu Gly Ile Thr Ser Cys Pro Tyr 180 185 190 ccg cac aat aag aaa aat att tca aaa 603 Pro His Asn Lys Lys Asn Ile Ser Lys 195 200 <210> 182 <211> 201 <212> PRT <213> Neisseria meningitidis <400> 182 Met Thr Ile Met Asn Ile Asn Thr Ser Glu Asn Lys Asp Ala Val Ala 1 5 10 15 Glu His Thr Gly Gln Trp Leu Glu Lys Ala Val Ile Gly Leu Asn Leu 20 25 30 Cys Pro Phe Ala Lys Ala Pro His Val Lys Asn Leu Val Arg Ile Ala 35 40 45 Ile Ser Glu Ala Lys His Leu Asp Ser Phe Leu Glu Asp Leu Asp Glu 50 55 60 Glu Leu Gln Arg Leu Gly Asn Thr Pro Ala Thr Glu Leu Glu Thr Thr 65 70 75 80 Leu Leu Val His Pro Thr Leu Phe Pro Asp Phe Asp Val Phe Asn Asp 85 90 95 Met Leu Asp Ile Ala Asp Ala Ala Val Val Glu Asn Gly Leu Glu Gly 100 105 110 Ile Ile Gln Ile Ala Pro Phe His Pro Asp Phe Gln Phe Glu Gly Thr 115 120 125 Asp Ser Asp Asp Ile Gly Asn Tyr Thr Asn Arg Ser Pro Tyr Pro Thr 130 135 140 Leu His Leu Ile Arg Glu Asp Ser Ile Ala Lys Ala Ala Gln Ala Phe 145 150 155 160 Pro Asp Ala Ser Ala Ile Phe Glu Arg Asn Ile Ala Leu Leu Glu Lys 165 170 175 Met Gly His Glu Gly Trp Ala Lys Leu Gly Ile Thr Ser Cys Pro Tyr 180 185 190 Pro His Asn Lys Lys Asn Ile Ser Lys 195 200 <210> 183 <211> 1338 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1338) <400> 183 ttg cac acc ctt cta gct ttt atc ttc gcc atc ctg att ttg gtc agc 48 Leu His Thr Leu Leu Ala Phe Ile Phe Ala Ile Leu Ile Leu Val Ser 1 5 10 15 ctg cac gaa ttc gga cac tac atc gtc gcc aga ttg tgc ggc gtc aag 96 Leu His Glu Phe Gly His Tyr Ile Val Ala Arg Leu Cys Gly Val Lys 20 25 30 gtt gtg cgt ttt tcc gtc ggc ttc ggc aaa ccg ttt ttc acc cga aag 144 Val Val Arg Phe Ser Val Gly Phe Gly Lys Pro Phe Phe Thr Arg Lys 35 40 45 cgc ggc gac acc gaa tgg tgc ctc gcc ccg att ccg ttg ggc ggt tac 192 Arg Gly Asp Thr Glu Trp Cys Leu Ala Pro Ile Pro Leu Gly Gly Tyr 50 55 60 gtc aaa atg gtc gac acg cgc gaa ggc gaa gta tca gaa gcc gat tta 240 Val Lys Met Val Asp Thr Arg Glu Gly Glu Val Ser Glu Ala Asp Leu 65 70 75 80 ccc tac gct ttt gac aaa caa cac ccc gcc aag cgc atc gcc atc gtc 288 Pro Tyr Ala Phe Asp Lys Gln His Pro Ala Lys Arg Ile Ala Ile Val 85 90 95 gcc gcc ggc ccg ctg acc aac ctc gca ctg gcg gtt ttg ctg tac gga 336 Ala Ala Gly Pro Leu Thr Asn Leu Ala Leu Ala Val Leu Leu Tyr Gly 100 105 110 ctg agc ttt tcc ttc ggc gtt acc gaa ctg cgc ccc tat gtc ggc aca 384 Leu Ser Phe Ser Phe Gly Val Thr Glu Leu Arg Pro Tyr Val Gly Thr 115 120 125 gtc gaa ccc gac acc att gcc gcc cgc gcc ggc ttc caa agc ggc gac 432 Val Glu Pro Asp Thr Ile Ala Ala Arg Ala Gly Phe Gln Ser Gly Asp 130 135 140 aaa ata caa tcc gtc aac ggc aca ccc gtt gca gat tgg ggc agc gcg 480 Lys Ile Gln Ser Val Asn Gly Thr Pro Val Ala Asp Trp Gly Ser Ala 145 150 155 160 caa acc gaa atc gtc ctc aac ctc gaa gcc ggc aaa gtc gcc gtc ggc 528 Gln Thr Glu Ile Val Leu Asn Leu Glu Ala Gly Lys Val Ala Val Gly 165 170 175 gtt cag acg gca tcg ggc gcg caa acc gtc cgc acc atc gat gcc gca 576 Val Gln Thr Ala Ser Gly Ala Gln Thr Val Arg Thr Ile Asp Ala Ala 180 185 190 ggc acg ccg gaa gcc ggt aaa atc gca aaa aac caa ggc tac atc gga 624 Gly Thr Pro Glu Ala Gly Lys Ile Ala Lys Asn Gln Gly Tyr Ile Gly 195 200 205 ctg atg ccc ttt aaa atc aca acc gtt gcc ggc ggc gtg gaa aaa ggc 672 Leu Met Pro Phe Lys Ile Thr Thr Val Ala Gly Gly Val Glu Lys Gly 210 215 220 agc ccc gcc gaa aaa gca ggc ctg aaa ccg ggc gac agg ctg act gcc 720 Ser Pro Ala Glu Lys Ala Gly Leu Lys Pro Gly Asp Arg Leu Thr Ala 225 230 235 240 gcc gac ggc aaa ccc atc gcc tca tgg caa gaa tgg gca aac ctg acc 768 Ala Asp Gly Lys Pro Ile Ala Ser Trp Gln Glu Trp Ala Asn Leu Thr 245 250 255 cgc caa agc ccc ggc aaa aaa atc acc ctg acc tac gaa cgc gcc gga 816 Arg Gln Ser Pro Gly Lys Lys Ile Thr Leu Thr Tyr Glu Arg Ala Gly 260 265 270 caa acc cat acc gcc gac atc cgc ccc gat act gtc gaa cag ccc gac 864 Gln Thr His Thr Ala Asp Ile Arg Pro Asp Thr Val Glu Gln Pro Asp 275 280 285 cac acc ctg atc ggg cgc gtc ggc ctc cgt ccg cag ccg gac agg gcg 912 His Thr Leu Ile Gly Arg Val Gly Leu Arg Pro Gln Pro Asp Arg Ala 290 295 300 tgg gac gcg caa atc cgc cgc agc tac cgt ccg tct gtt gtc cgc gca 960 Trp Asp Ala Gln Ile Arg Arg Ser Tyr Arg Pro Ser Val Val Arg Ala 305 310 315 320 ttc ggc atg ggc tgg gaa aaa acc gtt tcc cac tcg tgg aca acc ctc 1008 Phe Gly Met Gly Trp Glu Lys Thr Val Ser His Ser Trp Thr Thr Leu 325 330 335 aaa ttt ttc ggc aaa cta atc agc ggc aac gcc tcc gtc agc cat att 1056 Lys Phe Phe Gly Lys Leu Ile Ser Gly Asn Ala Ser Val Ser His Ile 340 345 350 tcc ggt ccg ctg acc att gcc gat att gcc gga cag tcc gcc gaa ctc 1104 Ser Gly Pro Leu Thr Ile Ala Asp Ile Ala Gly Gln Ser Ala Glu Leu 355 360 365 ggc ttg caa agt tat ttg gaa ttt ttg gca ctg gtc agc atc agc ctc 1152 Gly Leu Gln Ser Tyr Leu Glu Phe Leu Ala Leu Val Ser Ile Ser Leu 370 375 380 ggc gtg ctg aac ctg ctg ccc gtc ccc gtt ttg gac ggc ggc cac ctc 1200 Gly Val Leu Asn Leu Leu Pro Val Pro Val Leu Asp Gly Gly His Leu 385 390 395 400 gtg ttt tat act gcc gaa tgg ata cgc ggc aaa cct ttg ggc gaa cgc 1248 Val Phe Tyr Thr Ala Glu Trp Ile Arg Gly Lys Pro Leu Gly Glu Arg 405 410 415 gtc caa aac atc ggt ttg cgc ttc ggg ctt gcc ctc atg atg ctg atg 1296 Val Gln Asn Ile Gly Leu Arg Phe Gly Leu Ala Leu Met Met Leu Met 420 425 430 atg gcg gtc gcc ttc ttc aac gac gtt acc cgg ctg ctc ggt 1338 Met Ala Val Ala Phe Phe Asn Asp Val Thr Arg Leu Leu Gly 435 440 445 <210> 184 <211> 446 <212> PRT <213> Neisseria meningitidis <400> 184 Leu His Thr Leu Leu Ala Phe Ile Phe Ala Ile Leu Ile Leu Val Ser 1 5 10 15 Leu His Glu Phe Gly His Tyr Ile Val Ala Arg Leu Cys Gly Val Lys 20 25 30 Val Val Arg Phe Ser Val Gly Phe Gly Lys Pro Phe Phe Thr Arg Lys 35 40 45 Arg Gly Asp Thr Glu Trp Cys Leu Ala Pro Ile Pro Leu Gly Gly Tyr 50 55 60 Val Lys Met Val Asp Thr Arg Glu Gly Glu Val Ser Glu Ala Asp Leu 65 70 75 80 Pro Tyr Ala Phe Asp Lys Gln His Pro Ala Lys Arg Ile Ala Ile Val 85 90 95 Ala Ala Gly Pro Leu Thr Asn Leu Ala Leu Ala Val Leu Leu Tyr Gly 100 105 110 Leu Ser Phe Ser Phe Gly Val Thr Glu Leu Arg Pro Tyr Val Gly Thr 115 120 125 Val Glu Pro Asp Thr Ile Ala Ala Arg Ala Gly Phe Gln Ser Gly Asp 130 135 140 Lys Ile Gln Ser Val Asn Gly Thr Pro Val Ala Asp Trp Gly Ser Ala 145 150 155 160 Gln Thr Glu Ile Val Leu Asn Leu Glu Ala Gly Lys Val Ala Val Gly 165 170 175 Val Gln Thr Ala Ser Gly Ala Gln Thr Val Arg Thr Ile Asp Ala Ala 180 185 190 Gly Thr Pro Glu Ala Gly Lys Ile Ala Lys Asn Gln Gly Tyr Ile Gly 195 200 205 Leu Met Pro Phe Lys Ile Thr Thr Val Ala Gly Gly Val Glu Lys Gly 210 215 220 Ser Pro Ala Glu Lys Ala Gly Leu Lys Pro Gly Asp Arg Leu Thr Ala 225 230 235 240 Ala Asp Gly Lys Pro Ile Ala Ser Trp Gln Glu Trp Ala Asn Leu Thr 245 250 255 Arg Gln Ser Pro Gly Lys Lys Ile Thr Leu Thr Tyr Glu Arg Ala Gly 260 265 270 Gln Thr His Thr Ala Asp Ile Arg Pro Asp Thr Val Glu Gln Pro Asp 275 280 285 His Thr Leu Ile Gly Arg Val Gly Leu Arg Pro Gln Pro Asp Arg Ala 290 295 300 Trp Asp Ala Gln Ile Arg Arg Ser Tyr Arg Pro Ser Val Val Arg Ala 305 310 315 320 Phe Gly Met Gly Trp Glu Lys Thr Val Ser His Ser Trp Thr Thr Leu 325 330 335 Lys Phe Phe Gly Lys Leu Ile Ser Gly Asn Ala Ser Val Ser His Ile 340 345 350 Ser Gly Pro Leu Thr Ile Ala Asp Ile Ala Gly Gln Ser Ala Glu Leu 355 360 365 Gly Leu Gln Ser Tyr Leu Glu Phe Leu Ala Leu Val Ser Ile Ser Leu 370 375 380 Gly Val Leu Asn Leu Leu Pro Val Pro Val Leu Asp Gly Gly His Leu 385 390 395 400 Val Phe Tyr Thr Ala Glu Trp Ile Arg Gly Lys Pro Leu Gly Glu Arg 405 410 415 Val Gln Asn Ile Gly Leu Arg Phe Gly Leu Ala Leu Met Met Leu Met 420 425 430 Met Ala Val Ala Phe Phe Asn Asp Val Thr Arg Leu Leu Gly 435 440 445 <210> 185 <211> 1476 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1476) <400> 185 atg aaa tac aaa gac ctg cgc gac ttc atc gcc atg ctc gag cag cag 48 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 ggc aaa ctc aaa cgc atc gcg cac ccc gtt tcc ccg cat ttg gaa atg 96 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 acc gaa atc gcc gac cgc gtg ctg cgc gcc gaa ggg ccg gcg ttg ttg 144 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 ttt gaa cac cca gtt aag ccc gac ggt acg cgc tat gat tat ccc gtg 192 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 ttg gca aac ctg ttc ggc acg ccc gaa cgt gtg gcg atg ggc atg ggc 240 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 gcg gac agc gtg tcc aag ctg cgc gaa atc ggg cag acg ctg gcg tat 288 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 ttg aaa gaa ccc gaa ccg ccc aaa ggc att aaa gac gcg ttt tcc aaa 336 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 ctg ccg ctc ttg aaa gac att tgg agc atg gcg ccg aac gtg gtg aaa 384 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 aat gcg ccg tgt cag gaa atc gta tgg gaa ggc gaa gac gtt gat ttg 432 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 tat caa ctt ccg att cag cat tgc tgg ccg gaa gac gtt gcg ccg ctg 480 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 gta acg tgg ggc ttg acc gtc acg cgc ggg ccg cac aaa aaa cgc caa 528 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 aat ctc ggc att tac cgc caa caa tta atc ggc ata aac aag ctg att 576 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 atg cgc tgg ctg tcg cat cgc ggc ggc gcg ctg gat tat cag gaa ttc 624 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 cgc aaa ctc aat ccc gat acg ccg tat ccc gtc gcc gtc gtg ctc ggc 672 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 tgc gac cct gcc acc att ttg ggc gcg gta acg ccc gtt ccc gat acc 720 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 ttg agc gaa tac cag ttt gcc gga ctg ctg cgc ggt tcg cgg acg gaa 768 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 ctg gtg aaa tgt atc ggc aac gat ttg caa gtg cct gcc cgc gca gaa 816 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 atc gtg ttg gaa ggc gtc atc cat cca aac gaa acc gcg ttg gaa ggt 864 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 cca tac ggc gac cac acg ggc tat tac aac gag cag gac cat ttc ccc 912 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 gtg ttt acg gtc gaa cgc atc acc atg cgc gaa aac ccg att tac cac 960 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 tct acc tac aca ggc aaa ccg ccc gat gaa ccc gcc gtt ttg ggc gtg 1008 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 gcg ttg aac gaa gtg ttc gta ccg ctt ttg caa aag cag ttc ccc gaa 1056 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 atc acc gat ttt tac ctg ccg ccc gaa ggc tgc tcc tac cgc atg gcg 1104 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 gtg gtg agc atg aaa aaa cag tac gcc gga cac gcc aag cgc gtg atg 1152 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 atg ggc tgc tgg tcg ttc ctg cgc cag ttt atg tac acc aaa ttc atc 1200 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 att gtg gtg gat gac gat gtg gat gtg cgc gac tgg aaa gaa gtc atc 1248 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 tgg gcg gta acc acg cgc atg gac ccc gtg cgc gat acc gtt ttg atg 1296 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 gaa aac acg ccc atc gac tac ctc gac ttc gcc agc ccc gtc agc gga 1344 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 ctt ggc ggc aaa atg ggt ttg gat gcg acc aac aag tgg ccg ggc gaa 1392 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 acc gac cgc gaa tgg gga cgg gtg att aaa aaa gac cct gcg gtt acg 1440 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 gct aag att gat gag att tgg gag gaa ttg ggg ttg 1476 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 186 <211> 492 <212> PRT <213> Neisseria meningitidis <400> 186 Met Lys Tyr Lys Asp Leu Arg Asp Phe Ile Ala Met Leu Glu Gln Gln 1 5 10 15 Gly Lys Leu Lys Arg Ile Ala His Pro Val Ser Pro His Leu Glu Met 20 25 30 Thr Glu Ile Ala Asp Arg Val Leu Arg Ala Glu Gly Pro Ala Leu Leu 35 40 45 Phe Glu His Pro Val Lys Pro Asp Gly Thr Arg Tyr Asp Tyr Pro Val 50 55 60 Leu Ala Asn Leu Phe Gly Thr Pro Glu Arg Val Ala Met Gly Met Gly 65 70 75 80 Ala Asp Ser Val Ser Lys Leu Arg Glu Ile Gly Gln Thr Leu Ala Tyr 85 90 95 Leu Lys Glu Pro Glu Pro Pro Lys Gly Ile Lys Asp Ala Phe Ser Lys 100 105 110 Leu Pro Leu Leu Lys Asp Ile Trp Ser Met Ala Pro Asn Val Val Lys 115 120 125 Asn Ala Pro Cys Gln Glu Ile Val Trp Glu Gly Glu Asp Val Asp Leu 130 135 140 Tyr Gln Leu Pro Ile Gln His Cys Trp Pro Glu Asp Val Ala Pro Leu 145 150 155 160 Val Thr Trp Gly Leu Thr Val Thr Arg Gly Pro His Lys Lys Arg Gln 165 170 175 Asn Leu Gly Ile Tyr Arg Gln Gln Leu Ile Gly Ile Asn Lys Leu Ile 180 185 190 Met Arg Trp Leu Ser His Arg Gly Gly Ala Leu Asp Tyr Gln Glu Phe 195 200 205 Arg Lys Leu Asn Pro Asp Thr Pro Tyr Pro Val Ala Val Val Leu Gly 210 215 220 Cys Asp Pro Ala Thr Ile Leu Gly Ala Val Thr Pro Val Pro Asp Thr 225 230 235 240 Leu Ser Glu Tyr Gln Phe Ala Gly Leu Leu Arg Gly Ser Arg Thr Glu 245 250 255 Leu Val Lys Cys Ile Gly Asn Asp Leu Gln Val Pro Ala Arg Ala Glu 260 265 270 Ile Val Leu Glu Gly Val Ile His Pro Asn Glu Thr Ala Leu Glu Gly 275 280 285 Pro Tyr Gly Asp His Thr Gly Tyr Tyr Asn Glu Gln Asp His Phe Pro 290 295 300 Val Phe Thr Val Glu Arg Ile Thr Met Arg Glu Asn Pro Ile Tyr His 305 310 315 320 Ser Thr Tyr Thr Gly Lys Pro Pro Asp Glu Pro Ala Val Leu Gly Val 325 330 335 Ala Leu Asn Glu Val Phe Val Pro Leu Leu Gln Lys Gln Phe Pro Glu 340 345 350 Ile Thr Asp Phe Tyr Leu Pro Pro Glu Gly Cys Ser Tyr Arg Met Ala 355 360 365 Val Val Ser Met Lys Lys Gln Tyr Ala Gly His Ala Lys Arg Val Met 370 375 380 Met Gly Cys Trp Ser Phe Leu Arg Gln Phe Met Tyr Thr Lys Phe Ile 385 390 395 400 Ile Val Val Asp Asp Asp Val Asp Val Arg Asp Trp Lys Glu Val Ile 405 410 415 Trp Ala Val Thr Thr Arg Met Asp Pro Val Arg Asp Thr Val Leu Met 420 425 430 Glu Asn Thr Pro Ile Asp Tyr Leu Asp Phe Ala Ser Pro Val Ser Gly 435 440 445 Leu Gly Gly Lys Met Gly Leu Asp Ala Thr Asn Lys Trp Pro Gly Glu 450 455 460 Thr Asp Arg Glu Trp Gly Arg Val Ile Lys Lys Asp Pro Ala Val Thr 465 470 475 480 Ala Lys Ile Asp Glu Ile Trp Glu Glu Leu Gly Leu 485 490 <210> 187 <211> 1191 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1191) <400> 187 atg ttc ttc aag cac atc gaa gcc gcc ccc gcc gat ccg att ctc ggt 48 Met Phe Phe Lys His Ile Glu Ala Ala Pro Ala Asp Pro Ile Leu Gly 1 5 10 15 ttg ggc gaa gca ttc aaa gcc gaa acc cgc ccc gaa aaa gtc aac ctc 96 Leu Gly Glu Ala Phe Lys Ala Glu Thr Arg Pro Glu Lys Val Asn Leu 20 25 30 ggc atc ggc gtg tac aaa gac gca tcc ggc gcg aca cct att gtc aaa 144 Gly Ile Gly Val Tyr Lys Asp Ala Ser Gly Ala Thr Pro Ile Val Lys 35 40 45 gcc gtc aaa gaa gcc gaa aaa cgc ctg ttg gaa agc gaa aca act aaa 192 Ala Val Lys Glu Ala Glu Lys Arg Leu Leu Glu Ser Glu Thr Thr Lys 50 55 60 aac tac ctc acc atc gac ggc gtt gcc gac tac aac gag caa acc caa 240 Asn Tyr Leu Thr Ile Asp Gly Val Ala Asp Tyr Asn Glu Gln Thr Gln 65 70 75 80 att ctg ctg ttc ggc aaa gac cac gaa atc atc gcc agc cgt cgc gcc 288 Ile Leu Leu Phe Gly Lys Asp His Glu Ile Ile Ala Ser Arg Arg Ala 85 90 95 aaa aca gcg caa agc ctt ggc ggt aca ggc gca ttg cgt att gcg gcc 336 Lys Thr Ala Gln Ser Leu Gly Gly Thr Gly Ala Leu Arg Ile Ala Ala 100 105 110 gag ttt gcc aaa cgt cag ttg aac gcg caa acc atc tgg att tcc aat 384 Glu Phe Ala Lys Arg Gln Leu Asn Ala Gln Thr Ile Trp Ile Ser Asn 115 120 125 ccg act tgg ccc aac cac aac gcc atc gcc aaa gcg gtc ggt atc caa 432 Pro Thr Trp Pro Asn His Asn Ala Ile Ala Lys Ala Val Gly Ile Gln 130 135 140 gac caa cct tat cgc tac tat gat gcc gcc aaa cac ggt ttg gat tgg 480 Asp Gln Pro Tyr Arg Tyr Tyr Asp Ala Ala Lys His Gly Leu Asp Trp 145 150 155 160 gac ggt atg att gaa gac ttg agc caa gcg caa aaa ggc gac atc gtc 528 Asp Gly Met Ile Glu Asp Leu Ser Gln Ala Gln Lys Gly Asp Ile Val 165 170 175 ctg ctg cac ggc tgc tgc cac aac cct acc ggt atc gac cct acg ccc 576 Leu Leu His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Pro 180 185 190 gaa caa tgg gaa act ctg gca aaa ctt tct gcc gaa aaa ggc tgg tta 624 Glu Gln Trp Glu Thr Leu Ala Lys Leu Ser Ala Glu Lys Gly Trp Leu 195 200 205 ccg ctg ttt gac ttt gcc tac caa ggc ttc ggc aat ggt ttg gaa gaa 672 Pro Leu Phe Asp Phe Ala Tyr Gln Gly Phe Gly Asn Gly Leu Glu Glu 210 215 220 gat gcc tac ggc ctg cgc gtg ttc ttg aaa cac aat aca gaa ttg ctg 720 Asp Ala Tyr Gly Leu Arg Val Phe Leu Lys His Asn Thr Glu Leu Leu 225 230 235 240 att gcc agc tct tat tcc aaa aac ttc ggt atg tac aac gag cgc gtc 768 Ile Ala Ser Ser Tyr Ser Lys Asn Phe Gly Met Tyr Asn Glu Arg Val 245 250 255 ggc gcg ttc act ttg gtg gcc gaa gat gaa gca acc gcc gcc cgc gcc 816 Gly Ala Phe Thr Leu Val Ala Glu Asp Glu Ala Thr Ala Ala Arg Ala 260 265 270 cac agc caa gtc aaa acc att atc cgt acc ttg tat tcc aac cct gct 864 His Ser Gln Val Lys Thr Ile Ile Arg Thr Leu Tyr Ser Asn Pro Ala 275 280 285 tca cac ggc gcg aac act att gcg ctg gtg ttg aaa aat gat gat ttg 912 Ser His Gly Ala Asn Thr Ile Ala Leu Val Leu Lys Asn Asp Asp Leu 290 295 300 aaa gca caa tgg att gcc gaa ctc gat gaa atg cgc ggc cgt atc aaa 960 Lys Ala Gln Trp Ile Ala Glu Leu Asp Glu Met Arg Gly Arg Ile Lys 305 310 315 320 gcc atg cgc caa aaa ttt gtc gag ttg ctc aaa gcc aaa ggt gca act 1008 Ala Met Arg Gln Lys Phe Val Glu Leu Leu Lys Ala Lys Gly Ala Thr 325 330 335 caa gac ttt gat ttc att atc gaa caa aac ggc atg ttc tcc ttc agc 1056 Gln Asp Phe Asp Phe Ile Ile Glu Gln Asn Gly Met Phe Ser Phe Ser 340 345 350 ggc ttg act ccc gaa caa gtc gac cgt tta aaa aac gag ttt gcc att 1104 Gly Leu Thr Pro Glu Gln Val Asp Arg Leu Lys Asn Glu Phe Ala Ile 355 360 365 tat gcc gtc cgc tcc ggc cgc atc aac gtc gcc ggc att acc gac gac 1152 Tyr Ala Val Arg Ser Gly Arg Ile Asn Val Ala Gly Ile Thr Asp Asp 370 375 380 aac atc gat tat ctg tgc gaa agt atc gta aaa gta ctg 1191 Asn Ile Asp Tyr Leu Cys Glu Ser Ile Val Lys Val Leu 385 390 395 <210> 188 <211> 397 <212> PRT <213> Neisseria meningitidis <400> 188 Met Phe Phe Lys His Ile Glu Ala Ala Pro Ala Asp Pro Ile Leu Gly 1 5 10 15 Leu Gly Glu Ala Phe Lys Ala Glu Thr Arg Pro Glu Lys Val Asn Leu 20 25 30 Gly Ile Gly Val Tyr Lys Asp Ala Ser Gly Ala Thr Pro Ile Val Lys 35 40 45 Ala Val Lys Glu Ala Glu Lys Arg Leu Leu Glu Ser Glu Thr Thr Lys 50 55 60 Asn Tyr Leu Thr Ile Asp Gly Val Ala Asp Tyr Asn Glu Gln Thr Gln 65 70 75 80 Ile Leu Leu Phe Gly Lys Asp His Glu Ile Ile Ala Ser Arg Arg Ala 85 90 95 Lys Thr Ala Gln Ser Leu Gly Gly Thr Gly Ala Leu Arg Ile Ala Ala 100 105 110 Glu Phe Ala Lys Arg Gln Leu Asn Ala Gln Thr Ile Trp Ile Ser Asn 115 120 125 Pro Thr Trp Pro Asn His Asn Ala Ile Ala Lys Ala Val Gly Ile Gln 130 135 140 Asp Gln Pro Tyr Arg Tyr Tyr Asp Ala Ala Lys His Gly Leu Asp Trp 145 150 155 160 Asp Gly Met Ile Glu Asp Leu Ser Gln Ala Gln Lys Gly Asp Ile Val 165 170 175 Leu Leu His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Pro 180 185 190 Glu Gln Trp Glu Thr Leu Ala Lys Leu Ser Ala Glu Lys Gly Trp Leu 195 200 205 Pro Leu Phe Asp Phe Ala Tyr Gln Gly Phe Gly Asn Gly Leu Glu Glu 210 215 220 Asp Ala Tyr Gly Leu Arg Val Phe Leu Lys His Asn Thr Glu Leu Leu 225 230 235 240 Ile Ala Ser Ser Tyr Ser Lys Asn Phe Gly Met Tyr Asn Glu Arg Val 245 250 255 Gly Ala Phe Thr Leu Val Ala Glu Asp Glu Ala Thr Ala Ala Arg Ala 260 265 270 His Ser Gln Val Lys Thr Ile Ile Arg Thr Leu Tyr Ser Asn Pro Ala 275 280 285 Ser His Gly Ala Asn Thr Ile Ala Leu Val Leu Lys Asn Asp Asp Leu 290 295 300 Lys Ala Gln Trp Ile Ala Glu Leu Asp Glu Met Arg Gly Arg Ile Lys 305 310 315 320 Ala Met Arg Gln Lys Phe Val Glu Leu Leu Lys Ala Lys Gly Ala Thr 325 330 335 Gln Asp Phe Asp Phe Ile Ile Glu Gln Asn Gly Met Phe Ser Phe Ser 340 345 350 Gly Leu Thr Pro Glu Gln Val Asp Arg Leu Lys Asn Glu Phe Ala Ile 355 360 365 Tyr Ala Val Arg Ser Gly Arg Ile Asn Val Ala Gly Ile Thr Asp Asp 370 375 380 Asn Ile Asp Tyr Leu Cys Glu Ser Ile Val Lys Val Leu 385 390 395 <210> 189 <211> 462 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(462) <400> 189 ttg ctt tgc ccg gaa aaa atg tcg ggg atg gcg gga cag tat ccg tac 48 Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr 1 5 10 15 ggc gtc cgg tcg ggt ttg cgg agg aac ggc ttg aaa ctt tgg gat att 96 Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile 20 25 30 cat ttt aga atg acc cgt ttt atc gtc gca aga tgc ggt tta ttg ttt 144 His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe 35 40 45 gca acc ctt aaa gga aaa acc atg aag aaa atg ttc gtg ctg ttc tgt 192 Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys 50 55 60 atg ctg ttc tcc tgc gcc ttc tcc ctt gcg gcg gta aac atc aat gcg 240 Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala 65 70 75 80 gct tcg cag cag gag ctg gag gcg ctg ccg ggc ata ggc cct gcg aag 288 Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys 85 90 95 gcg aag gcc att gcg gaa tac cgt gcg caa aac ggt gcg ttc aag tct 336 Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser 100 105 110 gta gac gat ttg acc aag gta aag ggc atc ggc cct gcg gtg ctg gcg 384 Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala 115 120 125 aag ctg aag gat cag gct tct gtc ggt gcg ccc gca cca aaa ggc ccg 432 Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro 130 135 140 gca aaa ccg gct ctg ccc gca gct aaa aaa 462 Ala Lys Pro Ala Leu Pro Ala Ala Lys Lys 145 150 <210> 190 <211> 154 <212> PRT <213> Neisseria meningitidis <400> 190 Leu Leu Cys Pro Glu Lys Met Ser Gly Met Ala Gly Gln Tyr Pro Tyr 1 5 10 15 Gly Val Arg Ser Gly Leu Arg Arg Asn Gly Leu Lys Leu Trp Asp Ile 20 25 30 His Phe Arg Met Thr Arg Phe Ile Val Ala Arg Cys Gly Leu Leu Phe 35 40 45 Ala Thr Leu Lys Gly Lys Thr Met Lys Lys Met Phe Val Leu Phe Cys 50 55 60 Met Leu Phe Ser Cys Ala Phe Ser Leu Ala Ala Val Asn Ile Asn Ala 65 70 75 80 Ala Ser Gln Gln Glu Leu Glu Ala Leu Pro Gly Ile Gly Pro Ala Lys 85 90 95 Ala Lys Ala Ile Ala Glu Tyr Arg Ala Gln Asn Gly Ala Phe Lys Ser 100 105 110 Val Asp Asp Leu Thr Lys Val Lys Gly Ile Gly Pro Ala Val Leu Ala 115 120 125 Lys Leu Lys Asp Gln Ala Ser Val Gly Ala Pro Ala Pro Lys Gly Pro 130 135 140 Ala Lys Pro Ala Leu Pro Ala Ala Lys Lys 145 150 <210> 191 <211> 684 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(684) <400> 191 atg ttt gct ttt tta gaa gcc ttt ttt gtc gaa tac ggt tat gcg gct 48 Met Phe Ala Phe Leu Glu Ala Phe Phe Val Glu Tyr Gly Tyr Ala Ala 1 5 10 15 gtt ttt ttt gta ttg gtc atc tgc ggt ttc ggc gtg ccg att ccc gag 96 Val Phe Phe Val Leu Val Ile Cys Gly Phe Gly Val Pro Ile Pro Glu 20 25 30 gat ttg acc ttg gta aca ggc ggc gtg att tcg ggt atg ggt tat acc 144 Asp Leu Thr Leu Val Thr Gly Gly Val Ile Ser Gly Met Gly Tyr Thr 35 40 45 aat ccg cat att atg ttt gca gtc ggt atg ctc ggc gta ttg gtc ggg 192 Asn Pro His Ile Met Phe Ala Val Gly Met Leu Gly Val Leu Val Gly 50 55 60 gac ggc atc atg ttc gcc gcc gga cga att tgg ggg cag aaa atc cta 240 Asp Gly Ile Met Phe Ala Ala Gly Arg Ile Trp Gly Gln Lys Ile Leu 65 70 75 80 agg ttc aaa cct att gcg cgc atc atg acg ccg aaa cgt tat gag cag 288 Arg Phe Lys Pro Ile Ala Arg Ile Met Thr Pro Lys Arg Tyr Glu Gln 85 90 95 gtt cag gaa aaa ttc gac aaa tac ggt aac tgg gtc tta ttt gtc gcc 336 Val Gln Glu Lys Phe Asp Lys Tyr Gly Asn Trp Val Leu Phe Val Ala 100 105 110 cgt ttc ctg ccc ggt ttg aga acg gcc gta ttt gtt aca gcc ggt atc 384 Arg Phe Leu Pro Gly Leu Arg Thr Ala Val Phe Val Thr Ala Gly Ile 115 120 125 agc cgc aag gtt tca tac ttg cgt ttt atc att atg gat gga ctg gcc 432 Ser Arg Lys Val Ser Tyr Leu Arg Phe Ile Ile Met Asp Gly Leu Ala 130 135 140 gca ctg att tcc gtc cct att tgg att tat ctg ggc gaa tac ggt gcg 480 Ala Leu Ile Ser Val Pro Ile Trp Ile Tyr Leu Gly Glu Tyr Gly Ala 145 150 155 160 cac aac atc gat tgg ctg atg gcg aaa atg cac agc ctg caa tcg ggt 528 His Asn Ile Asp Trp Leu Met Ala Lys Met His Ser Leu Gln Ser Gly 165 170 175 att ttt gtt atc ttg ggt ata ggt gcg acc gtt gtc gct tgg att tgg 576 Ile Phe Val Ile Leu Gly Ile Gly Ala Thr Val Val Ala Trp Ile Trp 180 185 190 tgg aaa aaa cgc caa cgt atc cag ttt tac cgc agc aaa ttg aaa gaa 624 Trp Lys Lys Arg Gln Arg Ile Gln Phe Tyr Arg Ser Lys Leu Lys Glu 195 200 205 aag cgg gcg caa cgc aaa gcc gcc aag gca gcc aaa aaa gcc gcg caa 672 Lys Arg Ala Gln Arg Lys Ala Ala Lys Ala Ala Lys Lys Ala Ala Gln 210 215 220 agc aaa caa taa 684 Ser Lys Gln 225 <210> 192 <211> 227 <212> PRT <213> Neisseria meningitidis <400> 192 Met Phe Ala Phe Leu Glu Ala Phe Phe Val Glu Tyr Gly Tyr Ala Ala 1 5 10 15 Val Phe Phe Val Leu Val Ile Cys Gly Phe Gly Val Pro Ile Pro Glu 20 25 30 Asp Leu Thr Leu Val Thr Gly Gly Val Ile Ser Gly Met Gly Tyr Thr 35 40 45 Asn Pro His Ile Met Phe Ala Val Gly Met Leu Gly Val Leu Val Gly 50 55 60 Asp Gly Ile Met Phe Ala Ala Gly Arg Ile Trp Gly Gln Lys Ile Leu 65 70 75 80 Arg Phe Lys Pro Ile Ala Arg Ile Met Thr Pro Lys Arg Tyr Glu Gln 85 90 95 Val Gln Glu Lys Phe Asp Lys Tyr Gly Asn Trp Val Leu Phe Val Ala 100 105 110 Arg Phe Leu Pro Gly Leu Arg Thr Ala Val Phe Val Thr Ala Gly Ile 115 120 125 Ser Arg Lys Val Ser Tyr Leu Arg Phe Ile Ile Met Asp Gly Leu Ala 130 135 140 Ala Leu Ile Ser Val Pro Ile Trp Ile Tyr Leu Gly Glu Tyr Gly Ala 145 150 155 160 His Asn Ile Asp Trp Leu Met Ala Lys Met His Ser Leu Gln Ser Gly 165 170 175 Ile Phe Val Ile Leu Gly Ile Gly Ala Thr Val Val Ala Trp Ile Trp 180 185 190 Trp Lys Lys Arg Gln Arg Ile Gln Phe Tyr Arg Ser Lys Leu Lys Glu 195 200 205 Lys Arg Ala Gln Arg Lys Ala Ala Lys Ala Ala Lys Lys Ala Ala Gln 210 215 220 Ser Lys Gln 225 <210> 193 <211> 1089 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1089) <400> 193 atg aat gac tac acg cag cag ctt caa ggt aaa aaa gac tac ctt aaa 48 Met Asn Asp Tyr Thr Gln Gln Leu Gln Gly Lys Lys Asp Tyr Leu Lys 1 5 10 15 acc ctt ttt gca ggt ttg gat gtt cct gag tgg gaa gtg tac gaa tct 96 Thr Leu Phe Ala Gly Leu Asp Val Pro Glu Trp Glu Val Tyr Glu Ser 20 25 30 ccg gac aaa cat tac cgt atg cgt gcc gag ttc cgt att tgg cac gaa 144 Pro Asp Lys His Tyr Arg Met Arg Ala Glu Phe Arg Ile Trp His Glu 35 40 45 ggc ggg gaa atg ttt tat gcc atg ttt gaa aaa ggg cag aaa gcc agc 192 Gly Gly Glu Met Phe Tyr Ala Met Phe Glu Lys Gly Gln Lys Ala Ser 50 55 60 ggc gca agc atg ata cgc tgc gac cgt ttt gaa gca gct tcc gag gct 240 Gly Ala Ser Met Ile Arg Cys Asp Arg Phe Glu Ala Ala Ser Glu Ala 65 70 75 80 gtc aac cgc ctc atg ccc gag ctg atc gcc gcc gcc gcg caa tcc ccc 288 Val Asn Arg Leu Met Pro Glu Leu Ile Ala Ala Ala Ala Gln Ser Pro 85 90 95 gaa ctc aaa aaa cgc tgg tat gcc gtc gaa ttt ctg tcc acg ctc agc 336 Glu Leu Lys Lys Arg Trp Tyr Ala Val Glu Phe Leu Ser Thr Leu Ser 100 105 110 ggg gaa atg ctg gtt acc atg att tac cac aaa agg ctt gat gct gag 384 Gly Glu Met Leu Val Thr Met Ile Tyr His Lys Arg Leu Asp Ala Glu 115 120 125 tgg atg cag gcg gcg caa gcg tta cag caa cag ttg gat att tcc gtt 432 Trp Met Gln Ala Ala Gln Ala Leu Gln Gln Gln Leu Asp Ile Ser Val 130 135 140 att ggg cgg agc agg gga cag aaa ata gtc tta aaa cag gac tat gta 480 Ile Gly Arg Ser Arg Gly Gln Lys Ile Val Leu Lys Gln Asp Tyr Val 145 150 155 160 acg gaa act ttg aag gtc ggc aac cgg gat ttc cgt tat cgg caa att 528 Thr Glu Thr Leu Lys Val Gly Asn Arg Asp Phe Arg Tyr Arg Gln Ile 165 170 175 gaa ggc agt ttt acc caa ccg aat gcc gcc gtg tgt cag aaa atg ctt 576 Glu Gly Ser Phe Thr Gln Pro Asn Ala Ala Val Cys Gln Lys Met Leu 180 185 190 gaa tgg gcg tgc cgc acg gcg gaa ggc ttg ggc agc gac ctg ctc gaa 624 Glu Trp Ala Cys Arg Thr Ala Glu Gly Leu Gly Ser Asp Leu Leu Glu 195 200 205 ctg tat tgc gga aac ggc aat ttc acc ctg ccg ctg tcc cga tat ttc 672 Leu Tyr Cys Gly Asn Gly Asn Phe Thr Leu Pro Leu Ser Arg Tyr Phe 210 215 220 cga cag gtt ttg gca acc gaa atc tcc aaa acc tcc gtc agc gcg gcg 720 Arg Gln Val Leu Ala Thr Glu Ile Ser Lys Thr Ser Val Ser Ala Ala 225 230 235 240 caa tgg aat atc gaa gcc aac cgc atc ggc aac atc aaa atc gcc cgt 768 Gln Trp Asn Ile Glu Ala Asn Arg Ile Gly Asn Ile Lys Ile Ala Arg 245 250 255 ctg tct gct gaa gaa ttt acc gaa gcc tat acc gga aaa cgt gag ttt 816 Leu Ser Ala Glu Glu Phe Thr Glu Ala Tyr Thr Gly Lys Arg Glu Phe 260 265 270 aaa cgc ctt aag gat ggc ggt att gct ttg acg gat tac gca ttt tcc 864 Lys Arg Leu Lys Asp Gly Gly Ile Ala Leu Thr Asp Tyr Ala Phe Ser 275 280 285 act att ttc gtc gat ccg ccg cgt gcc ggt atc gat gag gaa act ttg 912 Thr Ile Phe Val Asp Pro Pro Arg Ala Gly Ile Asp Glu Glu Thr Leu 290 295 300 aag ctg gtg tcg cag ttt gac aac atc atc tac att tcc tgc aat ccc 960 Lys Leu Val Ser Gln Phe Asp Asn Ile Ile Tyr Ile Ser Cys Asn Pro 305 310 315 320 gaa acg ttg cgc gcc aat ttg gac acc ttg gcg gaa acc cat gcg gtc 1008 Glu Thr Leu Arg Ala Asn Leu Asp Thr Leu Ala Glu Thr His Ala Val 325 330 335 gaa cgt gcc gcc ctg ttc gac caa ttc ccg ttt acg cac cat atc gaa 1056 Glu Arg Ala Ala Leu Phe Asp Gln Phe Pro Phe Thr His His Ile Glu 340 345 350 agt ggt gta ttg ttg aaa aag aaa atc ctt tga 1089 Ser Gly Val Leu Leu Lys Lys Lys Ile Leu 355 360 <210> 194 <211> 362 <212> PRT <213> Neisseria meningitidis <400> 194 Met Asn Asp Tyr Thr Gln Gln Leu Gln Gly Lys Lys Asp Tyr Leu Lys 1 5 10 15 Thr Leu Phe Ala Gly Leu Asp Val Pro Glu Trp Glu Val Tyr Glu Ser 20 25 30 Pro Asp Lys His Tyr Arg Met Arg Ala Glu Phe Arg Ile Trp His Glu 35 40 45 Gly Gly Glu Met Phe Tyr Ala Met Phe Glu Lys Gly Gln Lys Ala Ser 50 55 60 Gly Ala Ser Met Ile Arg Cys Asp Arg Phe Glu Ala Ala Ser Glu Ala 65 70 75 80 Val Asn Arg Leu Met Pro Glu Leu Ile Ala Ala Ala Ala Gln Ser Pro 85 90 95 Glu Leu Lys Lys Arg Trp Tyr Ala Val Glu Phe Leu Ser Thr Leu Ser 100 105 110 Gly Glu Met Leu Val Thr Met Ile Tyr His Lys Arg Leu Asp Ala Glu 115 120 125 Trp Met Gln Ala Ala Gln Ala Leu Gln Gln Gln Leu Asp Ile Ser Val 130 135 140 Ile Gly Arg Ser Arg Gly Gln Lys Ile Val Leu Lys Gln Asp Tyr Val 145 150 155 160 Thr Glu Thr Leu Lys Val Gly Asn Arg Asp Phe Arg Tyr Arg Gln Ile 165 170 175 Glu Gly Ser Phe Thr Gln Pro Asn Ala Ala Val Cys Gln Lys Met Leu 180 185 190 Glu Trp Ala Cys Arg Thr Ala Glu Gly Leu Gly Ser Asp Leu Leu Glu 195 200 205 Leu Tyr Cys Gly Asn Gly Asn Phe Thr Leu Pro Leu Ser Arg Tyr Phe 210 215 220 Arg Gln Val Leu Ala Thr Glu Ile Ser Lys Thr Ser Val Ser Ala Ala 225 230 235 240 Gln Trp Asn Ile Glu Ala Asn Arg Ile Gly Asn Ile Lys Ile Ala Arg 245 250 255 Leu Ser Ala Glu Glu Phe Thr Glu Ala Tyr Thr Gly Lys Arg Glu Phe 260 265 270 Lys Arg Leu Lys Asp Gly Gly Ile Ala Leu Thr Asp Tyr Ala Phe Ser 275 280 285 Thr Ile Phe Val Asp Pro Pro Arg Ala Gly Ile Asp Glu Glu Thr Leu 290 295 300 Lys Leu Val Ser Gln Phe Asp Asn Ile Ile Tyr Ile Ser Cys Asn Pro 305 310 315 320 Glu Thr Leu Arg Ala Asn Leu Asp Thr Leu Ala Glu Thr His Ala Val 325 330 335 Glu Arg Ala Ala Leu Phe Asp Gln Phe Pro Phe Thr His His Ile Glu 340 345 350 Ser Gly Val Leu Leu Lys Lys Lys Ile Leu 355 360 <210> 195 <211> 2145 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2145) <400> 195 atg aat acc cca ttg ttc cgt ctc agc ctg ctc tcg ctt acc ctg gcg 48 Met Asn Thr Pro Leu Phe Arg Leu Ser Leu Leu Ser Leu Thr Leu Ala 1 5 10 15 gca ggt ttt gcc cat gcg gca gaa aat aat gcc aag gtc gta ctg gat 96 Ala Gly Phe Ala His Ala Ala Glu Asn Asn Ala Lys Val Val Leu Asp 20 25 30 acc gtt acc gta aaa ggc gac cgc caa ggc agc aaa atc cgt acc aac 144 Thr Val Thr Val Lys Gly Asp Arg Gln Gly Ser Lys Ile Arg Thr Asn 35 40 45 atc gtt acg ctg caa caa aaa gac gaa agc acc gca acc gat atg cgc 192 Ile Val Thr Leu Gln Gln Lys Asp Glu Ser Thr Ala Thr Asp Met Arg 50 55 60 gaa ctc tta aaa gaa gag ccc tcc atc gat ttc ggc ggc ggc aac ggc 240 Glu Leu Leu Lys Glu Glu Pro Ser Ile Asp Phe Gly Gly Gly Asn Gly 65 70 75 80 acg tcc caa ttc ctg acg ctg cgc ggc atg ggt caa aac tct gtc gac 288 Thr Ser Gln Phe Leu Thr Leu Arg Gly Met Gly Gln Asn Ser Val Asp 85 90 95 atc aag gtg gac aac gcc tat tcc gac agc caa atc ctt tac cac caa 336 Ile Lys Val Asp Asn Ala Tyr Ser Asp Ser Gln Ile Leu Tyr His Gln 100 105 110 ggc aga ttt att gtc gat ccc gct ttg gtt aaa gtc gtt tcc gta caa 384 Gly Arg Phe Ile Val Asp Pro Ala Leu Val Lys Val Val Ser Val Gln 115 120 125 aaa ggc gcg ggt tcc gcc tct gcc ggt atc ggc gcg acc aac ggc gcg 432 Lys Gly Ala Gly Ser Ala Ser Ala Gly Ile Gly Ala Thr Asn Gly Ala 130 135 140 atc atc acc aaa acc gtc gat gcc caa gac ctg ctc aaa ggc ttg gat 480 Ile Ile Thr Lys Thr Val Asp Ala Gln Asp Leu Leu Lys Gly Leu Asp 145 150 155 160 aaa aac tgg ggc gtg cgc ctc aac agc ggc ttt gcc agc aac gaa ggc 528 Lys Asn Trp Gly Val Arg Leu Asn Ser Gly Phe Ala Ser Asn Glu Gly 165 170 175 gta agc tac ggc gca agc gta ttc ggg aaa gag ggc aac ttc gac ggc 576 Val Ser Tyr Gly Ala Ser Val Phe Gly Lys Glu Gly Asn Phe Asp Gly 180 185 190 ttg ttc tct tac aac cgc aac aat gaa aaa gat tac gaa gca ggt aaa 624 Leu Phe Ser Tyr Asn Arg Asn Asn Glu Lys Asp Tyr Glu Ala Gly Lys 195 200 205 ggc ttc cgt aat aat ttc aac ggc ggc aaa acc gta ccg tac agc gcg 672 Gly Phe Arg Asn Asn Phe Asn Gly Gly Lys Thr Val Pro Tyr Ser Ala 210 215 220 ctg gac aaa cgc agc tac ctc gcc aaa atc gga aca agc ttc ggc gac 720 Leu Asp Lys Arg Ser Tyr Leu Ala Lys Ile Gly Thr Ser Phe Gly Asp 225 230 235 240 ggc gac cac cgc atc gta ttg agc cat atg aaa gac cag cac cgg ggc 768 Gly Asp His Arg Ile Val Leu Ser His Met Lys Asp Gln His Arg Gly 245 250 255 atc cgt acc gtc cgt gaa gaa ttt acc gtc ggc ggc gat aaa gag cga 816 Ile Arg Thr Val Arg Glu Glu Phe Thr Val Gly Gly Asp Lys Glu Arg 260 265 270 ata agt atg gaa cgc caa gcc cct gct tac cgc gaa acc aca caa tcc 864 Ile Ser Met Glu Arg Gln Ala Pro Ala Tyr Arg Glu Thr Thr Gln Ser 275 280 285 aac acc aat ttg gcg tac acg ggt aaa aac ctg ggc ttt gtc gaa aaa 912 Asn Thr Asn Leu Ala Tyr Thr Gly Lys Asn Leu Gly Phe Val Glu Lys 290 295 300 ctg gat gcc aac gcc tat gtg ttg gaa aaa gaa cgc tat tcc gcc gat 960 Leu Asp Ala Asn Ala Tyr Val Leu Glu Lys Glu Arg Tyr Ser Ala Asp 305 310 315 320 gac agc ggc acc ggt tac gca ggc aat gta aaa ggc ccc aac cat acc 1008 Asp Ser Gly Thr Gly Tyr Ala Gly Asn Val Lys Gly Pro Asn His Thr 325 330 335 caa atc acc act cgg ggt atg aac ttc aac ttc gac agc cgc ctt gcc 1056 Gln Ile Thr Thr Arg Gly Met Asn Phe Asn Phe Asp Ser Arg Leu Ala 340 345 350 gaa caa acc ctg ctg aaa tac ggt atc aac tac cgc cat cag gaa atc 1104 Glu Gln Thr Leu Leu Lys Tyr Gly Ile Asn Tyr Arg His Gln Glu Ile 355 360 365 aaa ccg caa gcg ttt ttg aat tca caa ttt aaa att gaa gat aaa gaa 1152 Lys Pro Gln Ala Phe Leu Asn Ser Gln Phe Lys Ile Glu Asp Lys Glu 370 375 380 aaa gca act gat gaa gag aaa aat aag aac cgt gaa aat gaa aaa att 1200 Lys Ala Thr Asp Glu Glu Lys Asn Lys Asn Arg Glu Asn Glu Lys Ile 385 390 395 400 gcc aaa gcc tac cgt ctg acc aac ccg acc aaa acc gat acc ggc gcg 1248 Ala Lys Ala Tyr Arg Leu Thr Asn Pro Thr Lys Thr Asp Thr Gly Ala 405 410 415 tat atc gaa gcc att cac gag att gac ggc ttt acc ctg acc ggc ggg 1296 Tyr Ile Glu Ala Ile His Glu Ile Asp Gly Phe Thr Leu Thr Gly Gly 420 425 430 ctg cgt tac gac cgc ttc aag gtg aaa acc cac gac ggc aaa acc gtt 1344 Leu Arg Tyr Asp Arg Phe Lys Val Lys Thr His Asp Gly Lys Thr Val 435 440 445 tca agc aac aac ctt aac ccg agt ttc ggc gtg att tgg cag ccg cac 1392 Ser Ser Asn Asn Leu Asn Pro Ser Phe Gly Val Ile Trp Gln Pro His 450 455 460 gaa cac tgg agc ttc agc gcg agc cac aac tac gcc agc cgc agc ccg 1440 Glu His Trp Ser Phe Ser Ala Ser His Asn Tyr Ala Ser Arg Ser Pro 465 470 475 480 cgc ctg tat gac gcg ctg caa acc cac ggc aaa cgc ggc atc atc tcg 1488 Arg Leu Tyr Asp Ala Leu Gln Thr His Gly Lys Arg Gly Ile Ile Ser 485 490 495 att gcc gac ggc acg aaa gcc gaa cgc gcg cgc aat acc gaa atc ggc 1536 Ile Ala Asp Gly Thr Lys Ala Glu Arg Ala Arg Asn Thr Glu Ile Gly 500 505 510 ttc aac tac aac gac ggc acg ttt gcc gca aac ggc agc tac ttc tgg 1584 Phe Asn Tyr Asn Asp Gly Thr Phe Ala Ala Asn Gly Ser Tyr Phe Trp 515 520 525 cag acc atc aaa gac gcg ctt gcc aat ccg caa aac cgc cac gac tct 1632 Gln Thr Ile Lys Asp Ala Leu Ala Asn Pro Gln Asn Arg His Asp Ser 530 535 540 gtc gcc gtc cgt gaa gcc gtc aat gcc ggt tac atc aaa aac cac ggt 1680 Val Ala Val Arg Glu Ala Val Asn Ala Gly Tyr Ile Lys Asn His Gly 545 550 555 560 tac gaa ttg ggc gcg tcc tac cgc acc ggc ggc ctg act gcc aaa gtc 1728 Tyr Glu Leu Gly Ala Ser Tyr Arg Thr Gly Gly Leu Thr Ala Lys Val 565 570 575 ggc gta agc cac agc aaa ccg cgc ttt tac gat acg cac aaa gac aag 1776 Gly Val Ser His Ser Lys Pro Arg Phe Tyr Asp Thr His Lys Asp Lys 580 585 590 ctg ttg agc gcg aat cct gaa ttt ggc gca caa gtc ggc cgc act tgg 1824 Leu Leu Ser Ala Asn Pro Glu Phe Gly Ala Gln Val Gly Arg Thr Trp 595 600 605 acg gct tcc ctt gcc tac cgc ttc caa aac ccg aat ctg gaa atc ggc 1872 Thr Ala Ser Leu Ala Tyr Arg Phe Gln Asn Pro Asn Leu Glu Ile Gly 610 615 620 tgg cgc ggc cgt tat gtt caa aaa gcc gtg ggt tcg ata ttg gtg gca 1920 Trp Arg Gly Arg Tyr Val Gln Lys Ala Val Gly Ser Ile Leu Val Ala 625 630 635 640 ggt caa aaa gac cgc aac ggc aaa ttg gaa aac gtt gta cgc aaa ggt 1968 Gly Gln Lys Asp Arg Asn Gly Lys Leu Glu Asn Val Val Arg Lys Gly 645 650 655 ttc ggt gtg aac gat gtc ttc gcc aac tgg aaa ccg ctg ggc aaa gac 2016 Phe Gly Val Asn Asp Val Phe Ala Asn Trp Lys Pro Leu Gly Lys Asp 660 665 670 acg ctc aat gtt aat ctt tcg gtt aac aac gtg ttc aac acg ttc tac 2064 Thr Leu Asn Val Asn Leu Ser Val Asn Asn Val Phe Asn Thr Phe Tyr 675 680 685 tat ccg cac agc caa cga tgg acc aat acc ctg ccg ggc gtg gga cgt 2112 Tyr Pro His Ser Gln Arg Trp Thr Asn Thr Leu Pro Gly Val Gly Arg 690 695 700 gat gta cgc ttg ggc gtg aac tac aag ttc taa 2145 Asp Val Arg Leu Gly Val Asn Tyr Lys Phe 705 710 715 <210> 196 <211> 714 <212> PRT <213> Neisseria meningitidis <400> 196 Met Asn Thr Pro Leu Phe Arg Leu Ser Leu Leu Ser Leu Thr Leu Ala 1 5 10 15 Ala Gly Phe Ala His Ala Ala Glu Asn Asn Ala Lys Val Val Leu Asp 20 25 30 Thr Val Thr Val Lys Gly Asp Arg Gln Gly Ser Lys Ile Arg Thr Asn 35 40 45 Ile Val Thr Leu Gln Gln Lys Asp Glu Ser Thr Ala Thr Asp Met Arg 50 55 60 Glu Leu Leu Lys Glu Glu Pro Ser Ile Asp Phe Gly Gly Gly Asn Gly 65 70 75 80 Thr Ser Gln Phe Leu Thr Leu Arg Gly Met Gly Gln Asn Ser Val Asp 85 90 95 Ile Lys Val Asp Asn Ala Tyr Ser Asp Ser Gln Ile Leu Tyr His Gln 100 105 110 Gly Arg Phe Ile Val Asp Pro Ala Leu Val Lys Val Val Ser Val Gln 115 120 125 Lys Gly Ala Gly Ser Ala Ser Ala Gly Ile Gly Ala Thr Asn Gly Ala 130 135 140 Ile Ile Thr Lys Thr Val Asp Ala Gln Asp Leu Leu Lys Gly Leu Asp 145 150 155 160 Lys Asn Trp Gly Val Arg Leu Asn Ser Gly Phe Ala Ser Asn Glu Gly 165 170 175 Val Ser Tyr Gly Ala Ser Val Phe Gly Lys Glu Gly Asn Phe Asp Gly 180 185 190 Leu Phe Ser Tyr Asn Arg Asn Asn Glu Lys Asp Tyr Glu Ala Gly Lys 195 200 205 Gly Phe Arg Asn Asn Phe Asn Gly Gly Lys Thr Val Pro Tyr Ser Ala 210 215 220 Leu Asp Lys Arg Ser Tyr Leu Ala Lys Ile Gly Thr Ser Phe Gly Asp 225 230 235 240 Gly Asp His Arg Ile Val Leu Ser His Met Lys Asp Gln His Arg Gly 245 250 255 Ile Arg Thr Val Arg Glu Glu Phe Thr Val Gly Gly Asp Lys Glu Arg 260 265 270 Ile Ser Met Glu Arg Gln Ala Pro Ala Tyr Arg Glu Thr Thr Gln Ser 275 280 285 Asn Thr Asn Leu Ala Tyr Thr Gly Lys Asn Leu Gly Phe Val Glu Lys 290 295 300 Leu Asp Ala Asn Ala Tyr Val Leu Glu Lys Glu Arg Tyr Ser Ala Asp 305 310 315 320 Asp Ser Gly Thr Gly Tyr Ala Gly Asn Val Lys Gly Pro Asn His Thr 325 330 335 Gln Ile Thr Thr Arg Gly Met Asn Phe Asn Phe Asp Ser Arg Leu Ala 340 345 350 Glu Gln Thr Leu Leu Lys Tyr Gly Ile Asn Tyr Arg His Gln Glu Ile 355 360 365 Lys Pro Gln Ala Phe Leu Asn Ser Gln Phe Lys Ile Glu Asp Lys Glu 370 375 380 Lys Ala Thr Asp Glu Glu Lys Asn Lys Asn Arg Glu Asn Glu Lys Ile 385 390 395 400 Ala Lys Ala Tyr Arg Leu Thr Asn Pro Thr Lys Thr Asp Thr Gly Ala 405 410 415 Tyr Ile Glu Ala Ile His Glu Ile Asp Gly Phe Thr Leu Thr Gly Gly 420 425 430 Leu Arg Tyr Asp Arg Phe Lys Val Lys Thr His Asp Gly Lys Thr Val 435 440 445 Ser Ser Asn Asn Leu Asn Pro Ser Phe Gly Val Ile Trp Gln Pro His 450 455 460 Glu His Trp Ser Phe Ser Ala Ser His Asn Tyr Ala Ser Arg Ser Pro 465 470 475 480 Arg Leu Tyr Asp Ala Leu Gln Thr His Gly Lys Arg Gly Ile Ile Ser 485 490 495 Ile Ala Asp Gly Thr Lys Ala Glu Arg Ala Arg Asn Thr Glu Ile Gly 500 505 510 Phe Asn Tyr Asn Asp Gly Thr Phe Ala Ala Asn Gly Ser Tyr Phe Trp 515 520 525 Gln Thr Ile Lys Asp Ala Leu Ala Asn Pro Gln Asn Arg His Asp Ser 530 535 540 Val Ala Val Arg Glu Ala Val Asn Ala Gly Tyr Ile Lys Asn His Gly 545 550 555 560 Tyr Glu Leu Gly Ala Ser Tyr Arg Thr Gly Gly Leu Thr Ala Lys Val 565 570 575 Gly Val Ser His Ser Lys Pro Arg Phe Tyr Asp Thr His Lys Asp Lys 580 585 590 Leu Leu Ser Ala Asn Pro Glu Phe Gly Ala Gln Val Gly Arg Thr Trp 595 600 605 Thr Ala Ser Leu Ala Tyr Arg Phe Gln Asn Pro Asn Leu Glu Ile Gly 610 615 620 Trp Arg Gly Arg Tyr Val Gln Lys Ala Val Gly Ser Ile Leu Val Ala 625 630 635 640 Gly Gln Lys Asp Arg Asn Gly Lys Leu Glu Asn Val Val Arg Lys Gly 645 650 655 Phe Gly Val Asn Asp Val Phe Ala Asn Trp Lys Pro Leu Gly Lys Asp 660 665 670 Thr Leu Asn Val Asn Leu Ser Val Asn Asn Val Phe Asn Thr Phe Tyr 675 680 685 Tyr Pro His Ser Gln Arg Trp Thr Asn Thr Leu Pro Gly Val Gly Arg 690 695 700 Asp Val Arg Leu Gly Val Asn Tyr Lys Phe 705 710 <210> 197 <211> 2625 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2625) <400> 197 atg aaa acc tcc gaa ctg cgc caa aaa ttc cta aaa ttt ttt gaa acc 48 Met Lys Thr Ser Glu Leu Arg Gln Lys Phe Leu Lys Phe Phe Glu Thr 1 5 10 15 aaa ggc cac acc gtc gtc cgc tct tcc agc ctc gtg ccg cac gac gac 96 Lys Gly His Thr Val Val Arg Ser Ser Ser Leu Val Pro His Asp Asp 20 25 30 ccg acc ctg ctg ttt acc aac gcg ggc atg aac cag ttt aaa gac gta 144 Pro Thr Leu Leu Phe Thr Asn Ala Gly Met Asn Gln Phe Lys Asp Val 35 40 45 ttc tta ggt ttc gac aaa cgc ccg tac agc cgc gcc acc acc gcg caa 192 Phe Leu Gly Phe Asp Lys Arg Pro Tyr Ser Arg Ala Thr Thr Ala Gln 50 55 60 aaa tgc gta cgc gca ggc ggc aaa cac aac gac ttg gaa aac gtc ggc 240 Lys Cys Val Arg Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly 65 70 75 80 tac acc gcc cgc cac cac acc ttc ttt gaa atg atg ggc aac ttc tcc 288 Tyr Thr Ala Arg His His Thr Phe Phe Glu Met Met Gly Asn Phe Ser 85 90 95 ttc ggc gac tac ttc aaa cgc gac gcc atc cac ttc gct tgg gaa ttt 336 Phe Gly Asp Tyr Phe Lys Arg Asp Ala Ile His Phe Ala Trp Glu Phe 100 105 110 ctg act tcc ccc gaa tgg ctc aac atc cct aaa gac aaa ctg ttg gcg 384 Leu Thr Ser Pro Glu Trp Leu Asn Ile Pro Lys Asp Lys Leu Leu Ala 115 120 125 acc gtt tac gcg gaa gac gac gaa gcc tac aac atc tgg ttg aac gaa 432 Thr Val Tyr Ala Glu Asp Asp Glu Ala Tyr Asn Ile Trp Leu Asn Glu 130 135 140 atc ggt atg ccg tcc gag cgc atc gtc cgc atc ggc gac aac aaa ggc 480 Ile Gly Met Pro Ser Glu Arg Ile Val Arg Ile Gly Asp Asn Lys Gly 145 150 155 160 gcg aaa tac gca tcc gac aac ttc tgg caa atg ggc gac acc ggc cct 528 Ala Lys Tyr Ala Ser Asp Asn Phe Trp Gln Met Gly Asp Thr Gly Pro 165 170 175 tgc ggc ccc tgc tcc gaa att ttc tac gac cac ggc gaa gaa atc tgg 576 Cys Gly Pro Cys Ser Glu Ile Phe Tyr Asp His Gly Glu Glu Ile Trp 180 185 190 ggc ggc att ccc ggc agt ccc gaa gaa gac ggc gac cgc tgg atc gaa 624 Gly Gly Ile Pro Gly Ser Pro Glu Glu Asp Gly Asp Arg Trp Ile Glu 195 200 205 att tgg aac tgc gta ttt atg cag ttc aac cgc gac gaa caa ggc aat 672 Ile Trp Asn Cys Val Phe Met Gln Phe Asn Arg Asp Glu Gln Gly Asn 210 215 220 atg aac ccg ctt ccc aaa cct tcc gtc gat acc ggt atg ggc ttg gaa 720 Met Asn Pro Leu Pro Lys Pro Ser Val Asp Thr Gly Met Gly Leu Glu 225 230 235 240 cgc ata gcc gcc gtc atg cag cat gtt cac agc aac tac gaa atc gac 768 Arg Ile Ala Ala Val Met Gln His Val His Ser Asn Tyr Glu Ile Asp 245 250 255 ttg ttc caa gac ctg ctc aaa gcc gtt gcc cgc gaa acc ggc gcg ccg 816 Leu Phe Gln Asp Leu Leu Lys Ala Val Ala Arg Glu Thr Gly Ala Pro 260 265 270 ttc aga atg gaa gaa ccc agc ctg aaa gtc atc gcc gac cac atc cgc 864 Phe Arg Met Glu Glu Pro Ser Leu Lys Val Ile Ala Asp His Ile Arg 275 280 285 tcc tgc tcg ttc ctg att gca gac ggc gtc ttg cct tcc aac gaa ggc 912 Ser Cys Ser Phe Leu Ile Ala Asp Gly Val Leu Pro Ser Asn Glu Gly 290 295 300 cgc ggc tac gta ttg cgc cgc att atc cgc cgc gcc gtg cgc cac ggt 960 Arg Gly Tyr Val Leu Arg Arg Ile Ile Arg Arg Ala Val Arg His Gly 305 310 315 320 tac aaa ctg ggt caa agc aaa ccg ttc ttc cac aaa ctc gtt gcc gat 1008 Tyr Lys Leu Gly Gln Ser Lys Pro Phe Phe His Lys Leu Val Ala Asp 325 330 335 ttg gtc aaa gag atg ggc ggt gcc tac cct gaa ttg aaa gaa aaa caa 1056 Leu Val Lys Glu Met Gly Gly Ala Tyr Pro Glu Leu Lys Glu Lys Gln 340 345 350 gcc caa atc gaa gaa gca ttg aaa aac gaa gaa agc cgt ttt gcc caa 1104 Ala Gln Ile Glu Glu Ala Leu Lys Asn Glu Glu Ser Arg Phe Ala Gln 355 360 365 acg ctg gaa acc ggt atg gct ttg ttg gaa aac gcg ctg gtc aaa ggc 1152 Thr Leu Glu Thr Gly Met Ala Leu Leu Glu Asn Ala Leu Val Lys Gly 370 375 380 ggc aaa aca ctc ggc ggc gaa atc atc ttc aaa ctc tac gat acc tac 1200 Gly Lys Thr Leu Gly Gly Glu Ile Ile Phe Lys Leu Tyr Asp Thr Tyr 385 390 395 400 ggt ttc cca tac gac ttg act gcc gac atc tgc cgc gaa cgc aat atc 1248 Gly Phe Pro Tyr Asp Leu Thr Ala Asp Ile Cys Arg Glu Arg Asn Ile 405 410 415 gaa ccg gac gaa gca ggc ttc gag cgc gaa atg gaa gcc caa cgc gca 1296 Glu Pro Asp Glu Ala Gly Phe Glu Arg Glu Met Glu Ala Gln Arg Ala 420 425 430 cgc gca cgc gcc gcc caa agc ttc aaa gcc aac gcc caa ctg cct tat 1344 Arg Ala Arg Ala Ala Gln Ser Phe Lys Ala Asn Ala Gln Leu Pro Tyr 435 440 445 gac ggt caa gac acc gag ttt aaa ggt tat agc gaa cgc caa acc gaa 1392 Asp Gly Gln Asp Thr Glu Phe Lys Gly Tyr Ser Glu Arg Gln Thr Glu 450 455 460 tcc aaa gtc ctc gcc ctc tac aaa gac ggc gag caa gtc aac gaa ttg 1440 Ser Lys Val Leu Ala Leu Tyr Lys Asp Gly Glu Gln Val Asn Glu Leu 465 470 475 480 aac gaa ggc gac agc ggc gca gtc gtc atc gac ttt acc ccg ttc tat 1488 Asn Glu Gly Asp Ser Gly Ala Val Val Ile Asp Phe Thr Pro Phe Tyr 485 490 495 gca gaa tcc ggc ggc caa gtc ggc gat gtc ggc tat atc ttc tca ggc 1536 Ala Glu Ser Gly Gly Gln Val Gly Asp Val Gly Tyr Ile Phe Ser Gly 500 505 510 gaa aac cgc ttt gaa gta cgc gat acc caa aaa atc aaa gcg gcc gta 1584 Glu Asn Arg Phe Glu Val Arg Asp Thr Gln Lys Ile Lys Ala Ala Val 515 520 525 ttc ggt caa ttc ggc gta caa act tca ggc cgt ctg aaa gtc ggc gac 1632 Phe Gly Gln Phe Gly Val Gln Thr Ser Gly Arg Leu Lys Val Gly Asp 530 535 540 agc gtt acc gcc aaa gtg gac gac gaa atc cgc aat gcc aat atg cgc 1680 Ser Val Thr Ala Lys Val Asp Asp Glu Ile Arg Asn Ala Asn Met Arg 545 550 555 560 aac cac agc gca acc cac ttg atg cac aaa gcc ctg cgc gat gta ttg 1728 Asn His Ser Ala Thr His Leu Met His Lys Ala Leu Arg Asp Val Leu 565 570 575 ggc aga cac gtc gaa caa aaa ggc tct ttg gtt acc gcc gaa tcc acc 1776 Gly Arg His Val Glu Gln Lys Gly Ser Leu Val Thr Ala Glu Ser Thr 580 585 590 cgt ttc gac att tcc cat ccc caa gcg gta act gcc gaa gaa att gcc 1824 Arg Phe Asp Ile Ser His Pro Gln Ala Val Thr Ala Glu Glu Ile Ala 595 600 605 gaa gta gaa cgc cgc gtc aac gaa gcc att ttg gcg aac gtt gcc gtc 1872 Glu Val Glu Arg Arg Val Asn Glu Ala Ile Leu Ala Asn Val Ala Val 610 615 620 aat gca gcc att atg agc atg gaa gac gcg caa aaa acc ggc gcg atg 1920 Asn Ala Ala Ile Met Ser Met Glu Asp Ala Gln Lys Thr Gly Ala Met 625 630 635 640 atg ctc ttc ggc gaa aaa tac ggc gaa gaa gtg cgc gta ctg caa atg 1968 Met Leu Phe Gly Glu Lys Tyr Gly Glu Glu Val Arg Val Leu Gln Met 645 650 655 ggc ggt ttc tct acc gaa ttg tgc ggc ggc aca cac gtt tca cgc acc 2016 Gly Gly Phe Ser Thr Glu Leu Cys Gly Gly Thr His Val Ser Arg Thr 660 665 670 ggc gac atc ggc ctc ttc aaa atc atc agc gaa ggc ggt att gcc gca 2064 Gly Asp Ile Gly Leu Phe Lys Ile Ile Ser Glu Gly Gly Ile Ala Ala 675 680 685 ggc gtg cgc cgt atc gaa gcc atc acc ggc ctg aac gca ctc aaa tgg 2112 Gly Val Arg Arg Ile Glu Ala Ile Thr Gly Leu Asn Ala Leu Lys Trp 690 695 700 gcg caa gag caa gag cgt ttg gtg aaa gac att att gcc gaa acc aaa 2160 Ala Gln Glu Gln Glu Arg Leu Val Lys Asp Ile Ile Ala Glu Thr Lys 705 710 715 720 gcc caa acc gaa aaa gac gta ctg gca aaa atc caa gca ggc gcg gca 2208 Ala Gln Thr Glu Lys Asp Val Leu Ala Lys Ile Gln Ala Gly Ala Ala 725 730 735 cac gcc aaa gca ttg gaa aaa gaa ttg gca cgc gcc aaa gcc gaa ctc 2256 His Ala Lys Ala Leu Glu Lys Glu Leu Ala Arg Ala Lys Ala Glu Leu 740 745 750 gcc gtc cac gca ggc gcc aaa ctc ttg gac gat gca aaa gac ttg ggc 2304 Ala Val His Ala Gly Ala Lys Leu Leu Asp Asp Ala Lys Asp Leu Gly 755 760 765 gca gcc aaa ctc gtt gcc gcc caa atc gaa gcc gac gca gcc gcc ctg 2352 Ala Ala Lys Leu Val Ala Ala Gln Ile Glu Ala Asp Ala Ala Ala Leu 770 775 780 cgc gaa atc gtt acc gat tta acc ggt aaa tcc gac aac gcc gtg att 2400 Arg Glu Ile Val Thr Asp Leu Thr Gly Lys Ser Asp Asn Ala Val Ile 785 790 795 800 ctt tta gcg gca gta aac gac ggc aaa gtc tcc ctg tgc gcc ggc gta 2448 Leu Leu Ala Ala Val Asn Asp Gly Lys Val Ser Leu Cys Ala Gly Val 805 810 815 tcc aaa ccg ttg acc ggc aaa gtg aaa gca ggc gat ctg gtt aaa ttt 2496 Ser Lys Pro Leu Thr Gly Lys Val Lys Ala Gly Asp Leu Val Lys Phe 820 825 830 gca gcc gaa caa gtc ggc ggc aaa ggc ggc ggc aga cca gat ttg gcg 2544 Ala Ala Glu Gln Val Gly Gly Lys Gly Gly Gly Arg Pro Asp Leu Ala 835 840 845 caa gcc ggc ggc acg gat gcc gac aaa ttg ccc gcc gtg ttg gat agc 2592 Gln Ala Gly Gly Thr Asp Ala Asp Lys Leu Pro Ala Val Leu Asp Ser 850 855 860 gtg aaa gac tgg gtc ggc gcg aag ctg gtt tga 2625 Val Lys Asp Trp Val Gly Ala Lys Leu Val 865 870 875 <210> 198 <211> 874 <212> PRT <213> Neisseria meningitidis <400> 198 Met Lys Thr Ser Glu Leu Arg Gln Lys Phe Leu Lys Phe Phe Glu Thr 1 5 10 15 Lys Gly His Thr Val Val Arg Ser Ser Ser Leu Val Pro His Asp Asp 20 25 30 Pro Thr Leu Leu Phe Thr Asn Ala Gly Met Asn Gln Phe Lys Asp Val 35 40 45 Phe Leu Gly Phe Asp Lys Arg Pro Tyr Ser Arg Ala Thr Thr Ala Gln 50 55 60 Lys Cys Val Arg Ala Gly Gly Lys His Asn Asp Leu Glu Asn Val Gly 65 70 75 80 Tyr Thr Ala Arg His His Thr Phe Phe Glu Met Met Gly Asn Phe Ser 85 90 95 Phe Gly Asp Tyr Phe Lys Arg Asp Ala Ile His Phe Ala Trp Glu Phe 100 105 110 Leu Thr Ser Pro Glu Trp Leu Asn Ile Pro Lys Asp Lys Leu Leu Ala 115 120 125 Thr Val Tyr Ala Glu Asp Asp Glu Ala Tyr Asn Ile Trp Leu Asn Glu 130 135 140 Ile Gly Met Pro Ser Glu Arg Ile Val Arg Ile Gly Asp Asn Lys Gly 145 150 155 160 Ala Lys Tyr Ala Ser Asp Asn Phe Trp Gln Met Gly Asp Thr Gly Pro 165 170 175 Cys Gly Pro Cys Ser Glu Ile Phe Tyr Asp His Gly Glu Glu Ile Trp 180 185 190 Gly Gly Ile Pro Gly Ser Pro Glu Glu Asp Gly Asp Arg Trp Ile Glu 195 200 205 Ile Trp Asn Cys Val Phe Met Gln Phe Asn Arg Asp Glu Gln Gly Asn 210 215 220 Met Asn Pro Leu Pro Lys Pro Ser Val Asp Thr Gly Met Gly Leu Glu 225 230 235 240 Arg Ile Ala Ala Val Met Gln His Val His Ser Asn Tyr Glu Ile Asp 245 250 255 Leu Phe Gln Asp Leu Leu Lys Ala Val Ala Arg Glu Thr Gly Ala Pro 260 265 270 Phe Arg Met Glu Glu Pro Ser Leu Lys Val Ile Ala Asp His Ile Arg 275 280 285 Ser Cys Ser Phe Leu Ile Ala Asp Gly Val Leu Pro Ser Asn Glu Gly 290 295 300 Arg Gly Tyr Val Leu Arg Arg Ile Ile Arg Arg Ala Val Arg His Gly 305 310 315 320 Tyr Lys Leu Gly Gln Ser Lys Pro Phe Phe His Lys Leu Val Ala Asp 325 330 335 Leu Val Lys Glu Met Gly Gly Ala Tyr Pro Glu Leu Lys Glu Lys Gln 340 345 350 Ala Gln Ile Glu Glu Ala Leu Lys Asn Glu Glu Ser Arg Phe Ala Gln 355 360 365 Thr Leu Glu Thr Gly Met Ala Leu Leu Glu Asn Ala Leu Val Lys Gly 370 375 380 Gly Lys Thr Leu Gly Gly Glu Ile Ile Phe Lys Leu Tyr Asp Thr Tyr 385 390 395 400 Gly Phe Pro Tyr Asp Leu Thr Ala Asp Ile Cys Arg Glu Arg Asn Ile 405 410 415 Glu Pro Asp Glu Ala Gly Phe Glu Arg Glu Met Glu Ala Gln Arg Ala 420 425 430 Arg Ala Arg Ala Ala Gln Ser Phe Lys Ala Asn Ala Gln Leu Pro Tyr 435 440 445 Asp Gly Gln Asp Thr Glu Phe Lys Gly Tyr Ser Glu Arg Gln Thr Glu 450 455 460 Ser Lys Val Leu Ala Leu Tyr Lys Asp Gly Glu Gln Val Asn Glu Leu 465 470 475 480 Asn Glu Gly Asp Ser Gly Ala Val Val Ile Asp Phe Thr Pro Phe Tyr 485 490 495 Ala Glu Ser Gly Gly Gln Val Gly Asp Val Gly Tyr Ile Phe Ser Gly 500 505 510 Glu Asn Arg Phe Glu Val Arg Asp Thr Gln Lys Ile Lys Ala Ala Val 515 520 525 Phe Gly Gln Phe Gly Val Gln Thr Ser Gly Arg Leu Lys Val Gly Asp 530 535 540 Ser Val Thr Ala Lys Val Asp Asp Glu Ile Arg Asn Ala Asn Met Arg 545 550 555 560 Asn His Ser Ala Thr His Leu Met His Lys Ala Leu Arg Asp Val Leu 565 570 575 Gly Arg His Val Glu Gln Lys Gly Ser Leu Val Thr Ala Glu Ser Thr 580 585 590 Arg Phe Asp Ile Ser His Pro Gln Ala Val Thr Ala Glu Glu Ile Ala 595 600 605 Glu Val Glu Arg Arg Val Asn Glu Ala Ile Leu Ala Asn Val Ala Val 610 615 620 Asn Ala Ala Ile Met Ser Met Glu Asp Ala Gln Lys Thr Gly Ala Met 625 630 635 640 Met Leu Phe Gly Glu Lys Tyr Gly Glu Glu Val Arg Val Leu Gln Met 645 650 655 Gly Gly Phe Ser Thr Glu Leu Cys Gly Gly Thr His Val Ser Arg Thr 660 665 670 Gly Asp Ile Gly Leu Phe Lys Ile Ile Ser Glu Gly Gly Ile Ala Ala 675 680 685 Gly Val Arg Arg Ile Glu Ala Ile Thr Gly Leu Asn Ala Leu Lys Trp 690 695 700 Ala Gln Glu Gln Glu Arg Leu Val Lys Asp Ile Ile Ala Glu Thr Lys 705 710 715 720 Ala Gln Thr Glu Lys Asp Val Leu Ala Lys Ile Gln Ala Gly Ala Ala 725 730 735 His Ala Lys Ala Leu Glu Lys Glu Leu Ala Arg Ala Lys Ala Glu Leu 740 745 750 Ala Val His Ala Gly Ala Lys Leu Leu Asp Asp Ala Lys Asp Leu Gly 755 760 765 Ala Ala Lys Leu Val Ala Ala Gln Ile Glu Ala Asp Ala Ala Ala Leu 770 775 780 Arg Glu Ile Val Thr Asp Leu Thr Gly Lys Ser Asp Asn Ala Val Ile 785 790 795 800 Leu Leu Ala Ala Val Asn Asp Gly Lys Val Ser Leu Cys Ala Gly Val 805 810 815 Ser Lys Pro Leu Thr Gly Lys Val Lys Ala Gly Asp Leu Val Lys Phe 820 825 830 Ala Ala Glu Gln Val Gly Gly Lys Gly Gly Gly Arg Pro Asp Leu Ala 835 840 845 Gln Ala Gly Gly Thr Asp Ala Asp Lys Leu Pro Ala Val Leu Asp Ser 850 855 860 Val Lys Asp Trp Val Gly Ala Lys Leu Val 865 870 <210> 199 <211> 207 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(207) <400> 199 gtg caa aga ggc cgt ctg aaa ggt ctc gtt tgc cgt agg ttg ggt cgc 48 Val Gln Arg Gly Arg Leu Lys Gly Leu Val Cys Arg Arg Leu Gly Arg 1 5 10 15 gac cca aca aat ttt gtg aag tat aaa aat gtt ggt cat gac cca acc 96 Asp Pro Thr Asn Phe Val Lys Tyr Lys Asn Val Gly His Asp Pro Thr 20 25 30 tac ctg cct ttt tgt aca aag agg cta tct gaa agg cct tgt ttg ccg 144 Tyr Leu Pro Phe Cys Thr Lys Arg Leu Ser Glu Arg Pro Cys Leu Pro 35 40 45 tat ggt ggg tcg cga ccc agc aga ttt tta tta ggg tat gac cca agc 192 Tyr Gly Gly Ser Arg Pro Ser Arg Phe Leu Leu Gly Tyr Asp Pro Ser 50 55 60 tac ttg cta cga taa 207 Tyr Leu Leu Arg 65 <210> 200 <211> 68 <212> PRT <213> Neisseria meningitidis <400> 200 Val Gln Arg Gly Arg Leu Lys Gly Leu Val Cys Arg Arg Leu Gly Arg 1 5 10 15 Asp Pro Thr Asn Phe Val Lys Tyr Lys Asn Val Gly His Asp Pro Thr 20 25 30 Tyr Leu Pro Phe Cys Thr Lys Arg Leu Ser Glu Arg Pro Cys Leu Pro 35 40 45 Tyr Gly Gly Ser Arg Pro Ser Arg Phe Leu Leu Gly Tyr Asp Pro Ser 50 55 60 Tyr Leu Leu Arg 65 <210> 201 <211> 2277 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(2277) <400> 201 atg gca caa act aca ctc aaa ccc att gtt tta tca att ctt tta atc 48 Met Ala Gln Thr Thr Leu Lys Pro Ile Val Leu Ser Ile Leu Leu Ile 1 5 10 15 aac aca ccc ctc ctc gcc caa gcg cat gaa act gag caa tcg gtg gat 96 Asn Thr Pro Leu Leu Ala Gln Ala His Glu Thr Glu Gln Ser Val Asp 20 25 30 ttg gaa acg gtc agc gtc gtc ggc aaa agc cgt ccg cgc gcc acg tcg 144 Leu Glu Thr Val Ser Val Val Gly Lys Ser Arg Pro Arg Ala Thr Ser 35 40 45 ggg ctg ttg cac act tcg acc gcc tcc gac aaa atc atc tcc ggc gat 192 Gly Leu Leu His Thr Ser Thr Ala Ser Asp Lys Ile Ile Ser Gly Asp 50 55 60 acc ttg cgc caa aaa gcc gtc aac ttg ggc gac gct tta gac ggc gta 240 Thr Leu Arg Gln Lys Ala Val Asn Leu Gly Asp Ala Leu Asp Gly Val 65 70 75 80 ccg ggc atc cac gct tcg caa tac ggc ggc ggc gcg tct gct ccc gtc 288 Pro Gly Ile His Ala Ser Gln Tyr Gly Gly Gly Ala Ser Ala Pro Val 85 90 95 att cgc ggt caa aca ggc agg cgg att aaa gtg ttg aac cat cac ggc 336 Ile Arg Gly Gln Thr Gly Arg Arg Ile Lys Val Leu Asn His His Gly 100 105 110 gaa aca ggc gat atg gcg gat ttt tcg ccc gat cac gcc att atg gta 384 Glu Thr Gly Asp Met Ala Asp Phe Ser Pro Asp His Ala Ile Met Val 115 120 125 gat acc gcc ttg tcg caa cag gtc gaa atc ctg cgc ggg ccg gtt acg 432 Asp Thr Ala Leu Ser Gln Gln Val Glu Ile Leu Arg Gly Pro Val Thr 130 135 140 ctc ttg tac agc tcg ggc aat gtg gcg ggg ctg gtc gat gtt gcc gat 480 Leu Leu Tyr Ser Ser Gly Asn Val Ala Gly Leu Val Asp Val Ala Asp 145 150 155 160 ggc aaa atc ccc gaa aaa atg cct gaa aac ggc gta tcg ggc gaa ctc 528 Gly Lys Ile Pro Glu Lys Met Pro Glu Asn Gly Val Ser Gly Glu Leu 165 170 175 gga ttg cgt ttg agc agc ggc aat ctg gaa aaa ctc acg tcc ggc ggc 576 Gly Leu Arg Leu Ser Ser Gly Asn Leu Glu Lys Leu Thr Ser Gly Gly 180 185 190 atc aat atc ggt ttg ggc aaa aac ttt gta ttg cac acg gaa ggg ctg 624 Ile Asn Ile Gly Leu Gly Lys Asn Phe Val Leu His Thr Glu Gly Leu 195 200 205 tac cgc aaa tcg ggg gat tac gcc gta ccg cgt tac cgc aat ctg aaa 672 Tyr Arg Lys Ser Gly Asp Tyr Ala Val Pro Arg Tyr Arg Asn Leu Lys 210 215 220 cgc ctg ccc gac agc cac gcc gat tcg caa acg ggc agc atc ggg ctg 720 Arg Leu Pro Asp Ser His Ala Asp Ser Gln Thr Gly Ser Ile Gly Leu 225 230 235 240 tct tgg gtt ggc gaa aaa ggt ttt atc ggc gta gcg tac agc gac cgt 768 Ser Trp Val Gly Glu Lys Gly Phe Ile Gly Val Ala Tyr Ser Asp Arg 245 250 255 cgc gac caa tat ggt ctg cct gcc cac agc cac gaa tac gat gat tgc 816 Arg Asp Gln Tyr Gly Leu Pro Ala His Ser His Glu Tyr Asp Asp Cys 260 265 270 cac gcc gac atc atc tgg caa aag agc ttg att aac aaa cgc tat tta 864 His Ala Asp Ile Ile Trp Gln Lys Ser Leu Ile Asn Lys Arg Tyr Leu 275 280 285 cag ctt tat ccg cac ctg ttg acc gaa gaa gac atc gat tac gac aat 912 Gln Leu Tyr Pro His Leu Leu Thr Glu Glu Asp Ile Asp Tyr Asp Asn 290 295 300 ccg ggc ttg agc tgc ggc ttc cac gac gac gat aat gca cac gca cac 960 Pro Gly Leu Ser Cys Gly Phe His Asp Asp Asp Asn Ala His Ala His 305 310 315 320 acc cac agc ggc aga ccg tgg ata gac ctg cgc aac aaa cgc tac gaa 1008 Thr His Ser Gly Arg Pro Trp Ile Asp Leu Arg Asn Lys Arg Tyr Glu 325 330 335 ctc cgt gcc gaa tgg aag caa ccg ttc ccc ggt ttt gaa gcc ctg cgc 1056 Leu Arg Ala Glu Trp Lys Gln Pro Phe Pro Gly Phe Glu Ala Leu Arg 340 345 350 gta cac ctg aac cgc aac gac tac cgc cac gac gaa aaa gca ggc gat 1104 Val His Leu Asn Arg Asn Asp Tyr Arg His Asp Glu Lys Ala Gly Asp 355 360 365 gca gtc gaa aac ttt ttt aac aac caa acg caa aac gcc cgc atc gag 1152 Ala Val Glu Asn Phe Phe Asn Asn Gln Thr Gln Asn Ala Arg Ile Glu 370 375 380 ttg cgc cac caa ccc ata ggt cgt ctg aaa ggc agc tgg ggc gtg caa 1200 Leu Arg His Gln Pro Ile Gly Arg Leu Lys Gly Ser Trp Gly Val Gln 385 390 395 400 tat tta caa caa aaa tcc agt gct tta tct gcc ata tcc gaa gcg gtt 1248 Tyr Leu Gln Gln Lys Ser Ser Ala Leu Ser Ala Ile Ser Glu Ala Val 405 410 415 aaa caa ccg atg ctg ctt gac aac aaa gtg caa cat tac agc ttt ttc 1296 Lys Gln Pro Met Leu Leu Asp Asn Lys Val Gln His Tyr Ser Phe Phe 420 425 430 ggt gta gaa cag gca aac tgg gac aac ttc acg ctt gaa gga ggc gta 1344 Gly Val Glu Gln Ala Asn Trp Asp Asn Phe Thr Leu Glu Gly Gly Val 435 440 445 cgc gtg gaa aaa caa aaa gcc tcc att cag tac gac aaa gca ttg att 1392 Arg Val Glu Lys Gln Lys Ala Ser Ile Gln Tyr Asp Lys Ala Leu Ile 450 455 460 gat cgg gaa aac tac tac aac cac ccc ctg ccc gac ctc ggc gcg cac 1440 Asp Arg Glu Asn Tyr Tyr Asn His Pro Leu Pro Asp Leu Gly Ala His 465 470 475 480 cgc caa acc gcc cgc tca ttc gca ctt tcg ggc aac tgg tat ttc acg 1488 Arg Gln Thr Ala Arg Ser Phe Ala Leu Ser Gly Asn Trp Tyr Phe Thr 485 490 495 cca caa cac aaa ctc agc ctg acc gcc tcc cat cag gaa cgc ctg ccg 1536 Pro Gln His Lys Leu Ser Leu Thr Ala Ser His Gln Glu Arg Leu Pro 500 505 510 tca acg caa gag ctg tac gca cac ggc aaa cac gtc gcc acc aac acc 1584 Ser Thr Gln Glu Leu Tyr Ala His Gly Lys His Val Ala Thr Asn Thr 515 520 525 ttt gaa gtc ggc aac aaa cac ctc aac aaa gag cgt tcc aac aat atc 1632 Phe Glu Val Gly Asn Lys His Leu Asn Lys Glu Arg Ser Asn Asn Ile 530 535 540 gaa ctc gcg ctg ggc tac gaa ggc gac cgc tgg caa tac aat ctg gca 1680 Glu Leu Ala Leu Gly Tyr Glu Gly Asp Arg Trp Gln Tyr Asn Leu Ala 545 550 555 560 ctc tac cgc aac cgc ttc ggt aac tac att tac gcc caa acc tta aac 1728 Leu Tyr Arg Asn Arg Phe Gly Asn Tyr Ile Tyr Ala Gln Thr Leu Asn 565 570 575 gac gga cgc ggc ccc aaa tcc atc gaa gac gac agc gaa atg aag ctc 1776 Asp Gly Arg Gly Pro Lys Ser Ile Glu Asp Asp Ser Glu Met Lys Leu 580 585 590 gtg cgc tac aac caa tcc ggc gcc gac ttc tac ggc gcg gaa ggc gaa 1824 Val Arg Tyr Asn Gln Ser Gly Ala Asp Phe Tyr Gly Ala Glu Gly Glu 595 600 605 atc tac ttc aaa ccg aca ccg cgc tac cgc atc ggc gtt tcc ggc gac 1872 Ile Tyr Phe Lys Pro Thr Pro Arg Tyr Arg Ile Gly Val Ser Gly Asp 610 615 620 tat gta cga ggc cgt ctg aaa aac ctg cct tcc cta ccc ggc aga gaa 1920 Tyr Val Arg Gly Arg Leu Lys Asn Leu Pro Ser Leu Pro Gly Arg Glu 625 630 635 640 gat gcc tac ggc aac cgt cct ttc atc gca cag gac gac caa aat gcc 1968 Asp Ala Tyr Gly Asn Arg Pro Phe Ile Ala Gln Asp Asp Gln Asn Ala 645 650 655 ccc cgt gtt ccg gct gcg cgc ctc ggc ttc cac ctg aaa gcc tcg ctg 2016 Pro Arg Val Pro Ala Ala Arg Leu Gly Phe His Leu Lys Ala Ser Leu 660 665 670 acc gac cgt atc gat gcc aat ttg gac tac tac cgc gtg ttc gcc caa 2064 Thr Asp Arg Ile Asp Ala Asn Leu Asp Tyr Tyr Arg Val Phe Ala Gln 675 680 685 aac aaa ctc gcc cgc tac gaa acg cgc acg ccc gga cac cat atg ctc 2112 Asn Lys Leu Ala Arg Tyr Glu Thr Arg Thr Pro Gly His His Met Leu 690 695 700 aac ctc ggc gca aac tac cgc cgc aat acg cgc tat ggc gag tgg aat 2160 Asn Leu Gly Ala Asn Tyr Arg Arg Asn Thr Arg Tyr Gly Glu Trp Asn 705 710 715 720 tgg tac gtc aaa gcc gac aac ctg ctc aac caa tcc gtt tac gcc cac 2208 Trp Tyr Val Lys Ala Asp Asn Leu Leu Asn Gln Ser Val Tyr Ala His 725 730 735 agc agc ttt ctc tct gat acg ccg caa atg ggc cgc agc ttt acc ggc 2256 Ser Ser Phe Leu Ser Asp Thr Pro Gln Met Gly Arg Ser Phe Thr Gly 740 745 750 ggc gtg aac gtg aag ttt taa 2277 Gly Val Asn Val Lys Phe 755 <210> 202 <211> 758 <212> PRT <213> Neisseria meningitidis <400> 202 Met Ala Gln Thr Thr Leu Lys Pro Ile Val Leu Ser Ile Leu Leu Ile 1 5 10 15 Asn Thr Pro Leu Leu Ala Gln Ala His Glu Thr Glu Gln Ser Val Asp 20 25 30 Leu Glu Thr Val Ser Val Val Gly Lys Ser Arg Pro Arg Ala Thr Ser 35 40 45 Gly Leu Leu His Thr Ser Thr Ala Ser Asp Lys Ile Ile Ser Gly Asp 50 55 60 Thr Leu Arg Gln Lys Ala Val Asn Leu Gly Asp Ala Leu Asp Gly Val 65 70 75 80 Pro Gly Ile His Ala Ser Gln Tyr Gly Gly Gly Ala Ser Ala Pro Val 85 90 95 Ile Arg Gly Gln Thr Gly Arg Arg Ile Lys Val Leu Asn His His Gly 100 105 110 Glu Thr Gly Asp Met Ala Asp Phe Ser Pro Asp His Ala Ile Met Val 115 120 125 Asp Thr Ala Leu Ser Gln Gln Val Glu Ile Leu Arg Gly Pro Val Thr 130 135 140 Leu Leu Tyr Ser Ser Gly Asn Val Ala Gly Leu Val Asp Val Ala Asp 145 150 155 160 Gly Lys Ile Pro Glu Lys Met Pro Glu Asn Gly Val Ser Gly Glu Leu 165 170 175 Gly Leu Arg Leu Ser Ser Gly Asn Leu Glu Lys Leu Thr Ser Gly Gly 180 185 190 Ile Asn Ile Gly Leu Gly Lys Asn Phe Val Leu His Thr Glu Gly Leu 195 200 205 Tyr Arg Lys Ser Gly Asp Tyr Ala Val Pro Arg Tyr Arg Asn Leu Lys 210 215 220 Arg Leu Pro Asp Ser His Ala Asp Ser Gln Thr Gly Ser Ile Gly Leu 225 230 235 240 Ser Trp Val Gly Glu Lys Gly Phe Ile Gly Val Ala Tyr Ser Asp Arg 245 250 255 Arg Asp Gln Tyr Gly Leu Pro Ala His Ser His Glu Tyr Asp Asp Cys 260 265 270 His Ala Asp Ile Ile Trp Gln Lys Ser Leu Ile Asn Lys Arg Tyr Leu 275 280 285 Gln Leu Tyr Pro His Leu Leu Thr Glu Glu Asp Ile Asp Tyr Asp Asn 290 295 300 Pro Gly Leu Ser Cys Gly Phe His Asp Asp Asp Asn Ala His Ala His 305 310 315 320 Thr His Ser Gly Arg Pro Trp Ile Asp Leu Arg Asn Lys Arg Tyr Glu 325 330 335 Leu Arg Ala Glu Trp Lys Gln Pro Phe Pro Gly Phe Glu Ala Leu Arg 340 345 350 Val His Leu Asn Arg Asn Asp Tyr Arg His Asp Glu Lys Ala Gly Asp 355 360 365 Ala Val Glu Asn Phe Phe Asn Asn Gln Thr Gln Asn Ala Arg Ile Glu 370 375 380 Leu Arg His Gln Pro Ile Gly Arg Leu Lys Gly Ser Trp Gly Val Gln 385 390 395 400 Tyr Leu Gln Gln Lys Ser Ser Ala Leu Ser Ala Ile Ser Glu Ala Val 405 410 415 Lys Gln Pro Met Leu Leu Asp Asn Lys Val Gln His Tyr Ser Phe Phe 420 425 430 Gly Val Glu Gln Ala Asn Trp Asp Asn Phe Thr Leu Glu Gly Gly Val 435 440 445 Arg Val Glu Lys Gln Lys Ala Ser Ile Gln Tyr Asp Lys Ala Leu Ile 450 455 460 Asp Arg Glu Asn Tyr Tyr Asn His Pro Leu Pro Asp Leu Gly Ala His 465 470 475 480 Arg Gln Thr Ala Arg Ser Phe Ala Leu Ser Gly Asn Trp Tyr Phe Thr 485 490 495 Pro Gln His Lys Leu Ser Leu Thr Ala Ser His Gln Glu Arg Leu Pro 500 505 510 Ser Thr Gln Glu Leu Tyr Ala His Gly Lys His Val Ala Thr Asn Thr 515 520 525 Phe Glu Val Gly Asn Lys His Leu Asn Lys Glu Arg Ser Asn Asn Ile 530 535 540 Glu Leu Ala Leu Gly Tyr Glu Gly Asp Arg Trp Gln Tyr Asn Leu Ala 545 550 555 560 Leu Tyr Arg Asn Arg Phe Gly Asn Tyr Ile Tyr Ala Gln Thr Leu Asn 565 570 575 Asp Gly Arg Gly Pro Lys Ser Ile Glu Asp Asp Ser Glu Met Lys Leu 580 585 590 Val Arg Tyr Asn Gln Ser Gly Ala Asp Phe Tyr Gly Ala Glu Gly Glu 595 600 605 Ile Tyr Phe Lys Pro Thr Pro Arg Tyr Arg Ile Gly Val Ser Gly Asp 610 615 620 Tyr Val Arg Gly Arg Leu Lys Asn Leu Pro Ser Leu Pro Gly Arg Glu 625 630 635 640 Asp Ala Tyr Gly Asn Arg Pro Phe Ile Ala Gln Asp Asp Gln Asn Ala 645 650 655 Pro Arg Val Pro Ala Ala Arg Leu Gly Phe His Leu Lys Ala Ser Leu 660 665 670 Thr Asp Arg Ile Asp Ala Asn Leu Asp Tyr Tyr Arg Val Phe Ala Gln 675 680 685 Asn Lys Leu Ala Arg Tyr Glu Thr Arg Thr Pro Gly His His Met Leu 690 695 700 Asn Leu Gly Ala Asn Tyr Arg Arg Asn Thr Arg Tyr Gly Glu Trp Asn 705 710 715 720 Trp Tyr Val Lys Ala Asp Asn Leu Leu Asn Gln Ser Val Tyr Ala His 725 730 735 Ser Ser Phe Leu Ser Asp Thr Pro Gln Met Gly Arg Ser Phe Thr Gly 740 745 750 Gly Val Asn Val Lys Phe 755 <210> 203 <211> 225 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(225) <400> 203 atg agg ctg gca acc aag gat ttg gcg gaa gcc att agg aaa gga cag 48 Met Arg Leu Ala Thr Lys Asp Leu Ala Glu Ala Ile Arg Lys Gly Gln 1 5 10 15 gtt cgc aaa tca agc ttt aac aca gaa caa tta agg gca att gaa aaa 96 Val Arg Lys Ser Ser Phe Asn Thr Glu Gln Leu Arg Ala Ile Glu Lys 20 25 30 gga gaa tct aaa ata ccg gat tac act tgg cat cat cat caa gat aca 144 Gly Glu Ser Lys Ile Pro Asp Tyr Thr Trp His His His Gln Asp Thr 35 40 45 gga agg atg caa ttg att cgt gaa ggc ttg cat cat gat acc ggc cat 192 Gly Arg Met Gln Leu Ile Arg Glu Gly Leu His His Asp Thr Gly His 50 55 60 att ggt tgg gaa gca atg aac aaa gga agg taa 225 Ile Gly Trp Glu Ala Met Asn Lys Gly Arg 65 70 75 <210> 204 <211> 74 <212> PRT <213> Neisseria meningitidis <400> 204 Met Arg Leu Ala Thr Lys Asp Leu Ala Glu Ala Ile Arg Lys Gly Gln 1 5 10 15 Val Arg Lys Ser Ser Phe Asn Thr Glu Gln Leu Arg Ala Ile Glu Lys 20 25 30 Gly Glu Ser Lys Ile Pro Asp Tyr Thr Trp His His His Gln Asp Thr 35 40 45 Gly Arg Met Gln Leu Ile Arg Glu Gly Leu His His Asp Thr Gly His 50 55 60 Ile Gly Trp Glu Ala Met Asn Lys Gly Arg 65 70 <210> 205 <211> 1176 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(1176) <400> 205 atg gca aaa atg atg aaa tgg gcg gct gtt gcg gcg gtc gcg gcg gca 48 Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala 1 5 10 15 gcg gtt tgg ggc gga tgg tct tat ctg aag ccc gag ccg cag gct gct 96 Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala 20 25 30 tat att acg gaa acg gtc agg cgc ggc gac atc agc cgg acg gtt tct 144 Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser 35 40 45 gca aca ggg gag att tcg ccg tcc aac ctg gta tcg gtc ggc gcg cag 192 Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln 50 55 60 gca tcg ggg cag att aag aaa ctt tat gtc aaa ctc ggg caa cag gtt 240 Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val 65 70 75 80 aaa aag ggc gat ttg att gcg gaa atc aat tcg acc tcg cag acc aat 288 Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn 85 90 95 acg ctc aat acg gaa aaa tcc aaa ttg gaa acg tat cag gcg aag ctg 336 Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu 100 105 110 gtg tcg gca cag att gca ttg ggc agc gcg gag aag aaa tat aag cgt 384 Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg 115 120 125 cag gcg gcg ttg tgg aag gat gat gcg acc gct aaa gaa gat ttg gaa 432 Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu 130 135 140 agc gca cag gat gcg ctt gcc gcc gcc aaa gcc aat gtt gcc gag ctg 480 Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu 145 150 155 160 aag gct cta atc aga cag agc aaa att tcc atc aat acc gcc gag tcg 528 Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser 165 170 175 gaa ttg ggc tac acg cgc att acc gca acg atg gac ggc acg gtg gtg 576 Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val 180 185 190 gcg att ctc gtg gaa gag ggg cag act gtg aac gcg gcg cag tct acg 624 Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr 195 200 205 ccg acg att gtc caa ttg gcg aat ctg gat atg atg ttg aac aaa atg 672 Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met 210 215 220 cag att gcc gag ggc gat att acc aag gtg aag gcg ggg cag gat att 720 Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile 225 230 235 240 tcg ttt acg att ttg tcc gaa ccg gat acg ccg att aag gcg aag ctc 768 Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu 245 250 255 gac agc gtc gac ccc ggg ctg acc acg atg tcg tcg ggc ggc tac aac 816 Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn 260 265 270 agc agt acg gat acg gct tcc aat gcg gtc tac tat tat gcc cgt tcg 864 Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser 275 280 285 ttt gtg ccg aat ccg gac ggc aaa ctc gcc acg ggg atg acg acg cag 912 Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln 290 295 300 aat acg gtt gaa atc gac ggt gtg aaa aat gtg ctg att att ccg tcg 960 Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser 305 310 315 320 ctg acc gtg aaa aat cgc ggc ggc agg gcg ttt gtg cgc gtg ttg ggt 1008 Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly 325 330 335 gca gac ggc aag gcg gcg gaa cgc gaa atc cgg acc ggt atg aga gac 1056 Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp 340 345 350 agt atg aat acc gaa gta aaa agc ggg ttg aaa gag ggg gac aaa gtg 1104 Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val 355 360 365 gtc atc tcc gaa ata acc gcc gcc gag cag cag gaa agc ggc gaa cgc 1152 Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg 370 375 380 gcc cta ggc ggc ccg ccg cgc cga 1176 Ala Leu Gly Gly Pro Pro Arg Arg 385 390 <210> 206 <211> 392 <212> PRT <213> Neisseria meningitidis <400> 206 Met Ala Lys Met Met Lys Trp Ala Ala Val Ala Ala Val Ala Ala Ala 1 5 10 15 Ala Val Trp Gly Gly Trp Ser Tyr Leu Lys Pro Glu Pro Gln Ala Ala 20 25 30 Tyr Ile Thr Glu Thr Val Arg Arg Gly Asp Ile Ser Arg Thr Val Ser 35 40 45 Ala Thr Gly Glu Ile Ser Pro Ser Asn Leu Val Ser Val Gly Ala Gln 50 55 60 Ala Ser Gly Gln Ile Lys Lys Leu Tyr Val Lys Leu Gly Gln Gln Val 65 70 75 80 Lys Lys Gly Asp Leu Ile Ala Glu Ile Asn Ser Thr Ser Gln Thr Asn 85 90 95 Thr Leu Asn Thr Glu Lys Ser Lys Leu Glu Thr Tyr Gln Ala Lys Leu 100 105 110 Val Ser Ala Gln Ile Ala Leu Gly Ser Ala Glu Lys Lys Tyr Lys Arg 115 120 125 Gln Ala Ala Leu Trp Lys Asp Asp Ala Thr Ala Lys Glu Asp Leu Glu 130 135 140 Ser Ala Gln Asp Ala Leu Ala Ala Ala Lys Ala Asn Val Ala Glu Leu 145 150 155 160 Lys Ala Leu Ile Arg Gln Ser Lys Ile Ser Ile Asn Thr Ala Glu Ser 165 170 175 Glu Leu Gly Tyr Thr Arg Ile Thr Ala Thr Met Asp Gly Thr Val Val 180 185 190 Ala Ile Leu Val Glu Glu Gly Gln Thr Val Asn Ala Ala Gln Ser Thr 195 200 205 Pro Thr Ile Val Gln Leu Ala Asn Leu Asp Met Met Leu Asn Lys Met 210 215 220 Gln Ile Ala Glu Gly Asp Ile Thr Lys Val Lys Ala Gly Gln Asp Ile 225 230 235 240 Ser Phe Thr Ile Leu Ser Glu Pro Asp Thr Pro Ile Lys Ala Lys Leu 245 250 255 Asp Ser Val Asp Pro Gly Leu Thr Thr Met Ser Ser Gly Gly Tyr Asn 260 265 270 Ser Ser Thr Asp Thr Ala Ser Asn Ala Val Tyr Tyr Tyr Ala Arg Ser 275 280 285 Phe Val Pro Asn Pro Asp Gly Lys Leu Ala Thr Gly Met Thr Thr Gln 290 295 300 Asn Thr Val Glu Ile Asp Gly Val Lys Asn Val Leu Ile Ile Pro Ser 305 310 315 320 Leu Thr Val Lys Asn Arg Gly Gly Arg Ala Phe Val Arg Val Leu Gly 325 330 335 Ala Asp Gly Lys Ala Ala Glu Arg Glu Ile Arg Thr Gly Met Arg Asp 340 345 350 Ser Met Asn Thr Glu Val Lys Ser Gly Leu Lys Glu Gly Asp Lys Val 355 360 365 Val Ile Ser Glu Ile Thr Ala Ala Glu Gln Gln Glu Ser Gly Glu Arg 370 375 380 Ala Leu Gly Gly Pro Pro Arg Arg 385 390 <210> 207 <211> 342 <212> DNA <213> Neisseria meningitidis <220> <221> CDS <222> (1)..(342) <400> 207 ttg ttt gta tgc ttt gaa aaa tgt ttg ttt ccg gat ttt gcc att ccc 48 Leu Phe Val Cys Phe Glu Lys Cys Leu Phe Pro Asp Phe Ala Ile Pro 1 5 10 15 atc cgg ttt tgc gct gta cga tgt gtt tta gcg cgg act tgc tca aaa 96 Ile Arg Phe Cys Ala Val Arg Cys Val Leu Ala Arg Thr Cys Ser Lys 20 25 30 tcg gat gtg gtt ccg gta ttt ggg gct ttg att agg gat gcg gac ttt 144 Ser Asp Val Val Pro Val Phe Gly Ala Leu Ile Arg Asp Ala Asp Phe 35 40 45 caa tat att ttt ctc agc tac aac aac gaa ggc ttg atg tct gtc ggg 192 Gln Tyr Ile Phe Leu Ser Tyr Asn Asn Glu Gly Leu Met Ser Val Gly 50 55 60 cag gta agg gag att ttt gag cgt ttc ggc aaa tat aat ttg gtt caa 240 Gln Val Arg Glu Ile Phe Glu Arg Phe Gly Lys Tyr Asn Leu Val Gln 65 70 75 80 acg gaa tat cgg cgt ttt aag gca gat aag aca gaa aac cgt aat cat 288 Thr Glu Tyr Arg Arg Phe Lys Ala Asp Lys Thr Glu Asn Arg Asn His 85 90 95 aag gca aat tcg ata ttc gaa tat ctg cat gag acc ttt gca aaa ata 336 Lys Ala Asn Ser Ile Phe Glu Tyr Leu His Glu Thr Phe Ala Lys Ile 100 105 110 gtc tgt 342 Val Cys <210> 208 <211> 114 <212> PRT <213> Neisseria meningitidis <400> 208 Leu Phe Val Cys Phe Glu Lys Cys Leu Phe Pro Asp Phe Ala Ile Pro 1 5 10 15 Ile Arg Phe Cys Ala Val Arg Cys Val Leu Ala Arg Thr Cys Ser Lys 20 25 30 Ser Asp Val Val Pro Val Phe Gly Ala Leu Ile Arg Asp Ala Asp Phe 35 40 45 Gln Tyr Ile Phe Leu Ser Tyr Asn Asn Glu Gly Leu Met Ser Val Gly 50 55 60 Gln Val Arg Glu Ile Phe Glu Arg Phe Gly Lys Tyr Asn Leu Val Gln 65 70 75 80 Thr Glu Tyr Arg Arg Phe Lys Ala Asp Lys Thr Glu Asn Arg Asn His 85 90 95 Lys Ala Asn Ser Ile Phe Glu Tyr Leu His Glu Thr Phe Ala Lys Ile 100 105 110 Val Cys <210> 209 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 209 ttggttaatt ggttgtaaca ctgg 24 <210> 210 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 210 attctcatgt ttgacagcg 19 <210> 211 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 211 atcctacaac ctcaagct 18 <210> 212 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 212 atcccattct aaccaagc 18 <210> 213 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 213 aagagattac gcgcagacc 19 <210> 214 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:Primer Sequence <400> 214 aatacgcaac cgcctctc 18

Claims (14)

  1. 치료 또는 진단에 사용하기 위한, 나이제리아 메닌지티디스의 SEQ ID NOS. 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 161, 163, 165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199, 201, 203, 205, 또는 207로 정의되는 뉴클레오티드 서열 중 어느 하나, 또는 그램-음성 박테리아에서 펩티드 또는 뉴클레오티드 수준에서 60% 이상의 서열 유사성 또는 동일성을 가지는 관련 분자, 또는 이의 기능성 단편을 포함하는 오페론에 의해 코드화되는 펩티드.
  2. 제 1항에 있어서, 상기 서열 유사성 또는 동일성이 90% 이상인 펩티드.
  3. 제 1항에 있어서, SEQ ID NOS. 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196, 198, 200, 202, 204, 206 또는 208로 정의된 아미노산 서열을 포함하는 펩티드.
  4. 치료 또는 진단에 사용하기 위한, 제1항 내지 제3항 중 어느 한 항에 따른 펩티드를 코드화하는 폴리뉴클레오티드.
  5. SEQ ID NO. 1로 정의된 뉴클레오티드 서열 또는 SEQ ID NO. 89 및 157로 정의된 서열을 제외한 제 1항에서 정의된 뉴클레오티드 서열 중 어느 하나의 발현을 파괴하는 돌연변이를 포함하는 감독된 미생물.
  6. 제 5항에 있어서, 상기 돌연변이는 삽입성 불활성 또는 유전자 결실인 미생물.
  7. 제 5항 또는 제 6항에 있어서, 상기 미생물이 나이제리아 메닌지티디스 (Neisseria meningitidis )인 미생물.
  8. 제 5항 또는 제 6항에 있어서, 이종성 항원을 포함하는 미생물.
  9. 제 1항 내지 제 3항 중 어느 한 항에 따른 펩티드를 포함하는 백신.
  10. 제 5항 또는 제 6항에 따른 미생물을 포함하는 백신.
  11. 제 1항 내지 제 3항 중 어느 한 항에 따른 펩티드에 대항하여 만들어지는 항체.
  12. 수막염의 예방 또는 치료에 사용하기 위한 제 1항 내지 제 3항, 제 5항 또는 제 6항 중 어느 한 항에 따른 생성물을 포함하는 약제.
  13. 제 12항에 있어서, 수의학적인 치료를 위한 약제.
  14. 항균성 약의 동정을 위한 선별 평가에 사용하기 위한 제 1항 내지 제 3항, 제 5항 또는 제 6항 중 어느 한 항에 따른 생성물.
KR1020070087191A 2000-05-08 2007-08-29 독성 유전자, 단백질, 및 그 용도 KR20070102447A (ko)

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GB0011108.8 2000-05-08

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EP1287024B1 (en) 2007-12-26
AU776508B2 (en) 2004-09-09
RU2005101623A (ru) 2006-07-10
NO20025329D0 (no) 2002-11-06
NZ522277A (en) 2004-05-28
WO2001085772A2 (en) 2001-11-15
AU5242201A (en) 2001-11-20
DE60132084D1 (de) 2008-02-07
NZ532297A (en) 2005-07-29
HUP0302481A2 (hu) 2003-10-28
US20040087770A1 (en) 2004-05-06
KR20030032948A (ko) 2003-04-26
US20080241151A1 (en) 2008-10-02
EP1908839A3 (en) 2008-07-16
CZ20023642A3 (cs) 2003-04-16
WO2001085772A3 (en) 2002-03-28
CN1427892A (zh) 2003-07-02
RU2252224C2 (ru) 2005-05-20
EP1287024A2 (en) 2003-03-05
KR20080080069A (ko) 2008-09-02
EP1908839A2 (en) 2008-04-09
CN1840665A (zh) 2006-10-04
DE60132084T2 (de) 2008-12-11
NO20025329L (no) 2003-01-06
GB0011108D0 (en) 2000-06-28
JP2003532404A (ja) 2003-11-05
NZ549068A (en) 2008-03-28
ATE382056T1 (de) 2008-01-15

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