KR20070087874A - 피부노화억제에 효과적인 키네틴의 리포좀기술을 이용한안정화 기술 및 이를 함유하는 화장료 조성물과 그의제조방법 - Google Patents
피부노화억제에 효과적인 키네틴의 리포좀기술을 이용한안정화 기술 및 이를 함유하는 화장료 조성물과 그의제조방법 Download PDFInfo
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- KR20070087874A KR20070087874A KR1020060002557A KR20060002557A KR20070087874A KR 20070087874 A KR20070087874 A KR 20070087874A KR 1020060002557 A KR1020060002557 A KR 1020060002557A KR 20060002557 A KR20060002557 A KR 20060002557A KR 20070087874 A KR20070087874 A KR 20070087874A
- Authority
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- South Korea
- Prior art keywords
- kinetin
- composition
- total weight
- liposome
- degrees
- Prior art date
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- FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 title claims abstract description 79
- QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 title claims abstract description 79
- 229960001669 kinetin Drugs 0.000 title claims abstract description 79
- 239000002502 liposome Substances 0.000 title claims abstract description 42
- 239000002537 cosmetic Substances 0.000 title claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 230000001153 anti-wrinkle effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 54
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 20
- 239000000787 lecithin Substances 0.000 claims abstract description 20
- 229940067606 lecithin Drugs 0.000 claims abstract description 20
- 235000010445 lecithin Nutrition 0.000 claims abstract description 20
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000006210 lotion Substances 0.000 claims abstract description 11
- 229940106189 ceramide Drugs 0.000 claims abstract description 9
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 8
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 8
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims abstract description 8
- 239000004310 lactic acid Substances 0.000 claims abstract description 8
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 8
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960000448 lactic acid Drugs 0.000 claims abstract description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical class CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 3
- 235000011187 glycerol Nutrition 0.000 claims abstract description 3
- 229920005615 natural polymer Chemical class 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 235000016709 nutrition Nutrition 0.000 claims description 9
- 230000035764 nutrition Effects 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 238000004945 emulsification Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 5
- 230000006641 stabilisation Effects 0.000 abstract description 3
- 238000011105 stabilization Methods 0.000 abstract description 3
- 230000000050 nutritive effect Effects 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000013589 supplement Substances 0.000 abstract 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Chemical class OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003796 beauty Effects 0.000 abstract 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Chemical class OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000811 xylitol Chemical class 0.000 abstract 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
- 235000010447 xylitol Nutrition 0.000 abstract 1
- 229960002675 xylitol Drugs 0.000 abstract 1
- 239000002994 raw material Substances 0.000 description 90
- 239000000243 solution Substances 0.000 description 40
- 230000000052 comparative effect Effects 0.000 description 20
- 150000002632 lipids Chemical class 0.000 description 12
- 239000008346 aqueous phase Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 239000000839 emulsion Substances 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 3
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 3
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 3
- 239000002211 L-ascorbic acid Substances 0.000 description 3
- 235000000069 L-ascorbic acid Nutrition 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 3
- 235000017471 coenzyme Q10 Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 description 3
- 229960004135 idebenone Drugs 0.000 description 3
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 3
- 235000019136 lipoic acid Nutrition 0.000 description 3
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229960002663 thioctic acid Drugs 0.000 description 3
- 229960000984 tocofersolan Drugs 0.000 description 3
- 229940035936 ubiquinone Drugs 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- -1 ziitol Polymers 0.000 description 1
Images
Classifications
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02B—HYDRAULIC ENGINEERING
- E02B3/00—Engineering works in connection with control or use of streams, rivers, coasts, or other marine sites; Sealings or joints for engineering works in general
- E02B3/04—Structures or apparatus for, or methods of, protecting banks, coasts, or harbours
- E02B3/12—Revetment of banks, dams, watercourses, or the like, e.g. the sea-floor
- E02B3/129—Polyhedrons, tetrapods or similar bodies, whether or not threaded on strings
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02B—HYDRAULIC ENGINEERING
- E02B3/00—Engineering works in connection with control or use of streams, rivers, coasts, or other marine sites; Sealings or joints for engineering works in general
- E02B3/04—Structures or apparatus for, or methods of, protecting banks, coasts, or harbours
- E02B3/06—Moles; Piers; Quays; Quay walls; Groynes; Breakwaters ; Wave dissipating walls; Quay equipment
- E02B3/08—Structures of loose stones with or without piles
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Environmental & Geological Engineering (AREA)
- Ocean & Marine Engineering (AREA)
- Mechanical Engineering (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (4)
- 키네틴을 리포좀 기법을 이용하여 안정화시킨 화장료 조성물.
- 레시틴, 세라마이드, 락틱애씨드, 키네틴 및 유화안정보조제의 리포좀을 함유하는 키네틴 함유 화장료 조성물로서,상기한 키네틴은 조성물 총 중량에 대해 0.01-2.0%의 양으로 함유되며,상기한 레시틴은 조성물 총 중량에 대해 1.0-10.0%의 양으로 함유되며,상기한 세라마이드는 조성물 총 중량에 대해 0.1-2.0%의 양으로 함유되며,상기한 락틱애씨드는 조성물 총 중량에 대해 0.1-40.0%의 양으로 함유되며,상기한 유화안정보조제로서는 프로필렌글리콜, 부틸렌글리콜, 글리세린, 자이리톨 또는 천연고분자화합물로부터 선택된 1종 또는 2종 이상의 혼합물로서, 조성물 총 중량에 대해 0.1-40.0%의 양으로 함유됨을 특징으로 하는 키네틴 함유 화장료 조성물.
- 정제수, 레시틴, 세라마이드 및 키네틴을 함유하는 혼합물을 고압균질기(High Pressure Homogenizer)에 통과시켜 키네틴 함유 리포좀이 고르게 분산된 키네틴함유 리포좀을 함유하는 화장료 조성물의 제조방법.
- 제 1항에 있어서, 상기 화장료가 화장수(스킨로션), 영양로션, 영양크림, 맛 사지크림 또는 영양에센스로 제형화됨을 특징으로 하는 화장료 조성물.
Priority Applications (1)
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KR1020060002557A KR100779819B1 (ko) | 2006-01-10 | 2006-01-10 | 피부노화억제에 효과적인 키네틴의 리포좀기술을 이용한안정화 기술 및 이를 함유하는 화장료 조성물과 그의제조방법 |
Applications Claiming Priority (1)
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KR1020060002557A KR100779819B1 (ko) | 2006-01-10 | 2006-01-10 | 피부노화억제에 효과적인 키네틴의 리포좀기술을 이용한안정화 기술 및 이를 함유하는 화장료 조성물과 그의제조방법 |
Publications (2)
Publication Number | Publication Date |
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KR20070087874A true KR20070087874A (ko) | 2007-08-29 |
KR100779819B1 KR100779819B1 (ko) | 2007-11-28 |
Family
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KR1020060002557A KR100779819B1 (ko) | 2006-01-10 | 2006-01-10 | 피부노화억제에 효과적인 키네틴의 리포좀기술을 이용한안정화 기술 및 이를 함유하는 화장료 조성물과 그의제조방법 |
Country Status (1)
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2345806A1 (es) * | 2009-03-30 | 2010-10-01 | Universidad De Santiago De Compostela | Sistemas nanoparticulares elaborados a base de polimeros anionicos para administrar moleculas bioactivas para uso cosmetico. |
Family Cites Families (5)
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JP2001031549A (ja) | 1999-07-14 | 2001-02-06 | Pola Chem Ind Inc | 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料 |
KR100385457B1 (ko) * | 2000-02-21 | 2003-05-27 | 주식회사 웰코스 | 리포좀 화장료 조성물 및 이를 제조하는 방법 |
KR20030025153A (ko) * | 2001-09-19 | 2003-03-28 | 이보섭 | 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물 |
US8021695B2 (en) * | 2002-02-15 | 2011-09-20 | Arch Personal Care Products, L.P. | Personal care composition containing leghemoglobin |
JP2004285032A (ja) | 2003-03-20 | 2004-10-14 | Api Corporation | カイネチンの水分散製剤およびその製造方法 |
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- 2006-01-10 KR KR1020060002557A patent/KR100779819B1/ko active IP Right Grant
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2345806A1 (es) * | 2009-03-30 | 2010-10-01 | Universidad De Santiago De Compostela | Sistemas nanoparticulares elaborados a base de polimeros anionicos para administrar moleculas bioactivas para uso cosmetico. |
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