KR20070083534A - 체중감량을 위한 부프로피온과 제2화합물의 조합 - Google Patents
체중감량을 위한 부프로피온과 제2화합물의 조합 Download PDFInfo
- Publication number
- KR20070083534A KR20070083534A KR1020077004999A KR20077004999A KR20070083534A KR 20070083534 A KR20070083534 A KR 20070083534A KR 1020077004999 A KR1020077004999 A KR 1020077004999A KR 20077004999 A KR20077004999 A KR 20077004999A KR 20070083534 A KR20070083534 A KR 20070083534A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- bupropion
- composition
- metabolite
- activity
- Prior art date
Links
- 0 Cc1c(-c(cc2)ccc2Cl)[n](-c(ccc(Cl)c2)c2Cl)nc1C(*N1CCCCC1)=O Chemical compound Cc1c(-c(cc2)ccc2Cl)[n](-c(ccc(Cl)c2)c2Cl)nc1C(*N1CCCCC1)=O 0.000 description 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59855804P | 2004-08-03 | 2004-08-03 | |
US60/598,558 | 2004-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20070083534A true KR20070083534A (ko) | 2007-08-24 |
Family
ID=35124494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020077004999A KR20070083534A (ko) | 2004-08-03 | 2005-08-01 | 체중감량을 위한 부프로피온과 제2화합물의 조합 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060058293A1 (ru) |
EP (1) | EP1773308A1 (ru) |
JP (1) | JP2008509142A (ru) |
KR (1) | KR20070083534A (ru) |
CN (1) | CN101001619A (ru) |
AR (1) | AR050600A1 (ru) |
AU (1) | AU2005271574A1 (ru) |
BR (1) | BRPI0514060A (ru) |
CA (1) | CA2576505A1 (ru) |
IL (1) | IL181086A0 (ru) |
MX (1) | MX2007001366A (ru) |
RU (1) | RU2007103313A (ru) |
TW (1) | TW200605866A (ru) |
WO (1) | WO2006017504A1 (ru) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7674776B2 (en) * | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
US7109198B2 (en) | 2002-05-17 | 2006-09-19 | Duke University | Method for treating obesity |
EP2316456B1 (en) | 2003-04-29 | 2017-06-14 | Orexigen Therapeutics, Inc. | Compositions for affecting weight loss comprising an opioid antagonist and bupropion |
US7713959B2 (en) | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
EP1734955A2 (en) | 2004-01-13 | 2006-12-27 | Duke University | Compositions of an anticonvulsant and an antipsychotic drug for affecting weigt loss |
US20060160750A1 (en) * | 2004-01-13 | 2006-07-20 | Krishnan K R R | Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss |
US20060100205A1 (en) * | 2004-04-21 | 2006-05-11 | Eckard Weber | Compositions for affecting weight loss |
CN1968692A (zh) * | 2004-05-03 | 2007-05-23 | 杜克大学 | 影响体重减轻的组合物 |
JP2008542378A (ja) * | 2005-05-31 | 2008-11-27 | オレキシジェン・セラピューティクス・インコーポレーテッド | 精神病性障害を管理する方法および組成物 |
EP1954257A4 (en) * | 2005-10-14 | 2009-05-20 | Lundbeck & Co As H | METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION |
EP1951212A2 (en) * | 2005-11-22 | 2008-08-06 | Orexigen Therapeutics, Inc. | Compositions and methods for increasing insulin sensitivity |
WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
AU2007222069A1 (en) * | 2006-02-21 | 2007-09-13 | Ampla Pharmaceuticals Inc. | CB1 antagonists and inverse agonists |
US8916195B2 (en) * | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
TW201811315A (zh) | 2006-11-09 | 2018-04-01 | 美商歐瑞根治療有限公司 | 層狀醫藥調配物 |
KR20090090316A (ko) | 2006-11-09 | 2009-08-25 | 오렉시젠 세러퓨틱스 인크. | 체중 감량 약물을 투여하기 위한 단위 용량 팩키지 및 투여 방법 |
US9044471B2 (en) * | 2007-02-01 | 2015-06-02 | Alan I. Green | Combinations of dopamine D2 receptor blockade with norepinephrine reuptake inhibition and with norepinephrine alpha 2 receptor blockade |
WO2009017755A2 (en) * | 2007-07-30 | 2009-02-05 | Ampla Pharmaceuticals Inc. | Cb1 antagonists and inverse agonists |
CA2725930A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
US20090304789A1 (en) | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
JPWO2010018856A1 (ja) * | 2008-08-13 | 2012-01-26 | 持田製薬株式会社 | カンナビノイド受容体関連疾患の予防/改善または治療剤 |
WO2010045416A2 (en) * | 2008-10-16 | 2010-04-22 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
US20100113604A1 (en) * | 2008-10-16 | 2010-05-06 | Aronne Louis J | Combination therapies for the treatment of obesity |
WO2010045522A2 (en) * | 2008-10-16 | 2010-04-22 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
US20100113581A1 (en) * | 2008-10-16 | 2010-05-06 | Aronne Louis J | Combination therapies for the treatment of obesity |
WO2010151503A2 (en) * | 2009-06-25 | 2010-12-29 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
WO2010151565A2 (en) * | 2009-06-26 | 2010-12-29 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
US20100331999A1 (en) * | 2009-06-29 | 2010-12-30 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
WO2011009115A2 (en) * | 2009-07-17 | 2011-01-20 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
US20110082407A1 (en) * | 2009-10-01 | 2011-04-07 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
ES2762113T3 (es) | 2010-01-11 | 2020-05-22 | Nalpropion Pharmaceuticals Inc | Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor |
EP2844235A1 (en) * | 2012-04-13 | 2015-03-11 | Banner Pharmacaps, Inc. | Soft elastic capsules containing tablets and liquid or semisolid fills and methods for their manufacture |
EP4104824A1 (en) | 2012-06-06 | 2022-12-21 | Nalpropion Pharmaceuticals LLC | Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk |
DE102013009114A1 (de) * | 2013-05-29 | 2014-12-04 | Franz Gerstheimer | Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen |
US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
US11331279B2 (en) | 2014-05-29 | 2022-05-17 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
US11911361B2 (en) | 2014-05-29 | 2024-02-27 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
JP2020517727A (ja) * | 2017-04-27 | 2020-06-18 | インシス・ディベロップメント・カンパニー・インコーポレイテッド | 安定なカンナビノイド製剤 |
CN113069438A (zh) * | 2021-04-01 | 2021-07-06 | 沈阳欣瑞制药有限公司 | 含有二甲双胍和安非他酮的药物组合物及其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2758723B1 (fr) * | 1997-01-28 | 1999-04-23 | Sanofi Sa | Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments |
JP2002501892A (ja) * | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な(−)−ビュープロピオンの薬学的使用 |
US20030144174A1 (en) * | 1998-12-09 | 2003-07-31 | Miles B. Brennan | Methods for identifying compounds useful for the regulation of body weight and associated conditions |
CZ20013607A3 (cs) * | 1999-04-06 | 2002-06-12 | Sepracor Inc. | Farmaceutický prostředek |
US7056890B2 (en) * | 1999-06-14 | 2006-06-06 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
GB2355191A (en) * | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
-
2005
- 2005-08-01 US US11/194,201 patent/US20060058293A1/en not_active Abandoned
- 2005-08-01 JP JP2007524915A patent/JP2008509142A/ja active Pending
- 2005-08-01 CN CNA2005800262874A patent/CN101001619A/zh active Pending
- 2005-08-01 MX MX2007001366A patent/MX2007001366A/es not_active Application Discontinuation
- 2005-08-01 CA CA002576505A patent/CA2576505A1/en not_active Abandoned
- 2005-08-01 EP EP05778421A patent/EP1773308A1/en not_active Withdrawn
- 2005-08-01 RU RU2007103313/15A patent/RU2007103313A/ru unknown
- 2005-08-01 WO PCT/US2005/027424 patent/WO2006017504A1/en active Application Filing
- 2005-08-01 AU AU2005271574A patent/AU2005271574A1/en not_active Abandoned
- 2005-08-01 KR KR1020077004999A patent/KR20070083534A/ko not_active Application Discontinuation
- 2005-08-01 BR BRPI0514060-9A patent/BRPI0514060A/pt not_active IP Right Cessation
- 2005-08-02 AR ARP050103216A patent/AR050600A1/es unknown
- 2005-08-03 TW TW094126409A patent/TW200605866A/zh unknown
-
2007
- 2007-01-31 IL IL181086A patent/IL181086A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2007103313A (ru) | 2008-09-10 |
MX2007001366A (es) | 2007-04-02 |
AR050600A1 (es) | 2006-11-08 |
EP1773308A1 (en) | 2007-04-18 |
IL181086A0 (en) | 2007-07-04 |
BRPI0514060A (pt) | 2008-05-27 |
CN101001619A (zh) | 2007-07-18 |
US20060058293A1 (en) | 2006-03-16 |
JP2008509142A (ja) | 2008-03-27 |
CA2576505A1 (en) | 2006-02-16 |
AU2005271574A1 (en) | 2006-02-16 |
TW200605866A (en) | 2006-02-16 |
WO2006017504A1 (en) | 2006-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |