KR20070057779A - 베타-아밀로이드 펩티드 생산을 저해함으로써알츠하이머병을 치료하는 화합물 및 이들의 제조 - Google Patents

베타-아밀로이드 펩티드 생산을 저해함으로써알츠하이머병을 치료하는 화합물 및 이들의 제조 Download PDF

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KR20070057779A
KR20070057779A KR1020077002317A KR20077002317A KR20070057779A KR 20070057779 A KR20070057779 A KR 20070057779A KR 1020077002317 A KR1020077002317 A KR 1020077002317A KR 20077002317 A KR20077002317 A KR 20077002317A KR 20070057779 A KR20070057779 A KR 20070057779A
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compound
formula
alkyl
aryl
oac
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KR1020077002317A
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도날드 더블유. 랜드리
쉬안 덩
태완 김
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더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕
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Priority claimed from US10/961,346 external-priority patent/US20060014704A1/en
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Publication of KR20070057779A publication Critical patent/KR20070057779A/ko

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KR1020077002317A 2004-07-16 2005-07-11 베타-아밀로이드 펩티드 생산을 저해함으로써알츠하이머병을 치료하는 화합물 및 이들의 제조 KR20070057779A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US58843304P 2004-07-16 2004-07-16
US60/588,433 2004-07-16
US10/961,346 2004-10-07
US10/961,346 US20060014704A1 (en) 2004-07-16 2004-10-07 Compounds and their preparation for the treatment of Alzheimer's disease by inhibiting beta-amyloid peptide production
US10/963,214 US20060014729A1 (en) 2004-07-16 2004-10-12 Compounds and their preparation for the treatment of Alzheimer's disease by inhibiting beta-amyloid peptide production
US10/963,214 2004-10-12

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KR20070057779A true KR20070057779A (ko) 2007-06-07

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KR1020077002317A KR20070057779A (ko) 2004-07-16 2005-07-11 베타-아밀로이드 펩티드 생산을 저해함으로써알츠하이머병을 치료하는 화합물 및 이들의 제조

Country Status (6)

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EP (1) EP1778715A2 (fr)
JP (1) JP2008506686A (fr)
KR (1) KR20070057779A (fr)
CA (1) CA2573699A1 (fr)
MX (1) MX2007000562A (fr)
WO (1) WO2006019685A2 (fr)

Cited By (1)

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KR102375097B1 (ko) 2021-04-01 2022-03-17 주식회사 클로소사이언스 항노화 유전자 klotho의 발현을 유도하는 화합물을 포함하는 퇴행성 신경질환의 예방 또는 치료용 조성물

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Publication number Priority date Publication date Assignee Title
CN101397327B (zh) * 2007-09-29 2012-01-11 广州天安医药科技有限公司 二氢人参皂苷Rg2的应用
CN104644658A (zh) * 2013-11-22 2015-05-27 富力 人参皂苷Rg3在制备用于预防或/和治疗痴呆病症药物中的应用及药物
CN105753923B (zh) * 2014-12-17 2017-09-29 富力 20(R)‑人参皂苷Rg3多酰基化衍生物、制备及其应用
KR101777920B1 (ko) 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
CN106046098B (zh) * 2016-06-15 2017-07-11 大连大学 一种乙酰基人参皂苷Rd及其制备方法
CN113633650A (zh) * 2021-08-26 2021-11-12 哈尔滨工业大学（威海） 一种抑制淀粉样蛋白产生的稀有人参皂苷及其应用
CN115025106A (zh) * 2022-07-12 2022-09-09 昆明理工大学 人参皂苷Rk3在制备具有神经保护作用药物中的用途

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JP3535588B2 (ja) * 1994-11-18 2004-06-07 株式会社ネオス ジンセノサイドＲｈ２の製造方法
CA2301860C (fr) * 1997-08-28 2009-05-26 Cv Technologies Inc. Standardisation chimique et pharmacologique des extraits de plantes medicinales
WO2002007732A2 (fr) * 2000-07-26 2002-01-31 Cambridge University Technical Services Limited Composes efficaces sur le plan pharmaceutique et utilisation associee
KR100448667B1 (ko) * 2001-04-25 2004-09-13 (주) 디지탈바이오텍 진세노사이드 가수분해물을 함유하는 퇴행성 뇌질환의예방 및 치료용 조성물
WO2004002494A1 (fr) * 2002-05-16 2004-01-08 Digital Biotech Co., Ltd. Composition pour la prevention ou le traitement d'affections cerebrales degeneratives, comprenant un hydrolysat de ginsenosides
KR20040036451A (ko) * 2002-10-26 2004-04-30 한국과학기술연구원 진세노사이드 Ｒｇ３ 또는 진세노사이드 Ｒｈ２를포함하는 글루타메이트 매개 신경독성 억제 조성물
KR20030088417A (ko) * 2003-11-06 2003-11-19 주식회사 케이티앤지 인삼 모상근을 이용한 기억력 증강 신규조성물진세노-제이케이와 그 제조방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102375097B1 (ko) 2021-04-01 2022-03-17 주식회사 클로소사이언스 항노화 유전자 klotho의 발현을 유도하는 화합물을 포함하는 퇴행성 신경질환의 예방 또는 치료용 조성물

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CA2573699A1 (fr) 2006-02-23
WO2006019685A2 (fr) 2006-02-23
WO2006019685A3 (fr) 2006-06-15
MX2007000562A (es) 2007-03-30
JP2008506686A (ja) 2008-03-06
EP1778715A2 (fr) 2007-05-02

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