KR20070047246A - 유로키나아제형 플라스미노겐 활성인자(uPA)와 그의수용체(uPAR)의 복합체에 결합하여 하류 uPAR상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도 - Google Patents

유로키나아제형 플라스미노겐 활성인자(uPA)와 그의수용체(uPAR)의 복합체에 결합하여 하류 uPAR상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도 Download PDF

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KR20070047246A
KR20070047246A KR1020067027198A KR20067027198A KR20070047246A KR 20070047246 A KR20070047246 A KR 20070047246A KR 1020067027198 A KR1020067027198 A KR 1020067027198A KR 20067027198 A KR20067027198 A KR 20067027198A KR 20070047246 A KR20070047246 A KR 20070047246A
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ligand
seq
upar
upa
atn
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그라함 씨. 페리
앤드류 피. 마자르
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아테뉴온, 엘엘씨
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • C07K2317/00Immunoglobulins specific features
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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KR1020067027198A 2004-05-25 2005-05-25 유로키나아제형 플라스미노겐 활성인자(uPA)와 그의수용체(uPAR)의 복합체에 결합하여 하류 uPAR상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도 Withdrawn KR20070047246A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57389604P 2004-05-25 2004-05-25
US60/573,896 2004-05-25

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KR20070047246A true KR20070047246A (ko) 2007-05-04

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KR1020067027198A Withdrawn KR20070047246A (ko) 2004-05-25 2005-05-25 유로키나아제형 플라스미노겐 활성인자(uPA)와 그의수용체(uPAR)의 복합체에 결합하여 하류 uPAR상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도

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US (1) US8101726B2 (enExample)
EP (1) EP1765397B1 (enExample)
JP (1) JP4890449B2 (enExample)
KR (1) KR20070047246A (enExample)
CN (1) CN101022830A (enExample)
AU (1) AU2005248400A1 (enExample)
CA (1) CA2568428C (enExample)
DK (1) DK1765397T3 (enExample)
ES (1) ES2398221T3 (enExample)
IL (1) IL179565A0 (enExample)
MX (1) MXPA06013709A (enExample)
PL (1) PL1765397T3 (enExample)
PT (1) PT1765397E (enExample)
RU (1) RU2006145905A (enExample)
WO (1) WO2005116077A2 (enExample)
ZA (1) ZA200610578B (enExample)

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WO2007109742A2 (en) * 2006-03-21 2007-09-27 Weaver David T Methods for humanizing antibodies and humanized antibodies made thereby
CN1919874B (zh) * 2006-09-18 2010-09-08 中国人民解放军军事医学科学院生物工程研究所 一种抗尿激酶型纤溶酶激活剂受体的抗体样分子ATF-Fc融合蛋白及其用途
US8105602B2 (en) * 2006-12-08 2012-01-31 Tactic Pharma, Llc Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof
US8815519B2 (en) 2006-12-22 2014-08-26 Hvidovre Hospital Method for predicting cancer and other diseases
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2730282A1 (en) * 2007-11-08 2014-05-14 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
EP2352503B1 (en) * 2008-11-06 2017-07-19 University of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
EP3187877A1 (en) 2009-09-25 2017-07-05 XOMA Technology Ltd. Screening methods
BR112013016107A2 (pt) 2010-12-22 2017-04-04 Ifom Fond Inst Firc Di Oncologia Molecolare molécula dimérica, método de tratamento de câncer, composição farmacêutica e kit para o diagnóstico de uma patologia ou tumor mediado(a) por upar
CA3027071A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
TWI700093B (zh) 2011-03-16 2020-08-01 法商賽諾菲公司 雙重v區類抗體蛋白質之用途
US9867923B2 (en) 2011-05-09 2018-01-16 University Of Miami Reducing soluble urokinase receptor in the circulation
CN103930128A (zh) 2011-08-05 2014-07-16 意大利癌症研究基金会分子肿瘤学研究所(Ifom) 组成型活性uPAR变体及其在抑制性抗体的生成与分离中的应用
KR102268883B1 (ko) * 2013-03-15 2021-06-28 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 누트린-3a 및 펩티드에 의한 폐 섬유증의 저해
CN105368859B (zh) * 2015-11-25 2019-10-18 王任直 一种嵌合抗原受体hCD87-CAR及载有hCD87-CAR基因结构的慢病毒及质粒及其应用
US10681506B1 (en) 2018-04-19 2020-06-09 Tango Tango, Inc. System and method for push-to-talk over cellular integration with software defined radio
US10959062B1 (en) 2018-04-19 2021-03-23 Tango Tango, Inc. System and method for push-to-talk over cellular integration with software defined radio
WO2020055812A1 (en) 2018-09-10 2020-03-19 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis
CA3114176A1 (en) * 2018-09-28 2020-04-02 Jochen Reiser Supar and prediction and treatment of acute kidney injury
EP4051714A4 (en) * 2019-10-28 2023-11-22 Monash University ANTIBODIES FOR BINDING PLASMIN
CN115867570A (zh) * 2020-06-15 2023-03-28 莫诺帕医疗公司 精确放射免疫治疗靶向尿激酶纤溶酶原激活剂受体(uPAR)以治疗严重COVID-19疾病
WO2022204267A1 (en) 2021-03-24 2022-09-29 Alkermes, Inc. Upar antibodies and fusion proteins with the same
EP4341265A4 (en) * 2021-05-21 2025-07-23 Northstar Medical Tech Llc TRIVALENT RADIOISTOPE BIO-TARGETED RADIOPHARMACEUTICAL, METHODS OF PREPARATION AND USE
CN117715648A (zh) * 2021-06-11 2024-03-15 纪念斯隆-凯特琳癌症中心 靶向uPAR的抗原识别受体和其用途
CA3246325A1 (en) * 2022-03-24 2023-09-28 The United States Government As Representative By The Department Of Veterans Affairs Urokinase-type plasminogen activator receptor-binding peptides and methods of use
EP4610269A1 (en) 2024-02-29 2025-09-03 3B Pharmaceuticals GmbH Urokinase plasminogen activator surface receptor (upar) ligands for diagnostic or therapeutic use
WO2025207781A1 (en) 2024-03-26 2025-10-02 Monopar Therapeutics Inc. Antibody radioisotope constructs

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US5532132A (en) * 1993-09-28 1996-07-02 President And Fellows Of Harvard University Method for regulating formation of a complex of plasminogen activator, its receptor and inhibitor
DE10117381A1 (de) * 2001-04-06 2002-10-10 Wilex Biotechnology Gmbh Herstellung polyklonaler, monospezifischer Antikörper gegen die uPAR-Varianten del4, del5 und del4+5 sowie deren Verwendung für diagnostische und therapeutische Zwecke
WO2003079974A2 (en) * 2002-03-18 2003-10-02 The Arizona Board Of Regents On Behalf Of The University Of Arizona Integrin ligand
US8105602B2 (en) * 2006-12-08 2012-01-31 Tactic Pharma, Llc Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof

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IL179565A0 (en) 2007-05-15
CN101022830A (zh) 2007-08-22
CA2568428A1 (en) 2005-12-08
PT1765397E (pt) 2013-02-04
EP1765397A4 (en) 2009-05-13
WO2005116077A3 (en) 2005-12-29
WO2005116077A2 (en) 2005-12-08
MXPA06013709A (es) 2008-01-16
US20090180952A1 (en) 2009-07-16
ZA200610578B (en) 2009-09-30
EP1765397B1 (en) 2012-10-24
JP4890449B2 (ja) 2012-03-07
RU2006145905A (ru) 2008-06-27
JP2008509086A (ja) 2008-03-27
AU2005248400A1 (en) 2005-12-08
US8101726B2 (en) 2012-01-24
PL1765397T3 (pl) 2013-04-30
CA2568428C (en) 2020-12-29
EP1765397A2 (en) 2007-03-28
ES2398221T3 (es) 2013-03-14
DK1765397T3 (da) 2013-02-04

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