JP4890449B2 - 下流ｕＰＡＲ相互作用を阻害するウロキナーゼ型プラスミノーゲン活性化因子（ｕＰＡ）とそのレセプター（ｕＰＡＲ）との複合体に結合するリガンド：診断または治療における同定および使用 - Google Patents

下流ｕＰＡＲ相互作用を阻害するウロキナーゼ型プラスミノーゲン活性化因子（ｕＰＡ）とそのレセプター（ｕＰＡＲ）との複合体に結合するリガンド：診断または治療における同定および使用 Download PDF

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JP4890449B2
JP4890449B2 JP2007515288A JP2007515288A JP4890449B2 JP 4890449 B2 JP4890449 B2 JP 4890449B2 JP 2007515288 A JP2007515288 A JP 2007515288A JP 2007515288 A JP2007515288 A JP 2007515288A JP 4890449 B2 JP4890449 B2 JP 4890449B2
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antigen
antibody
upar
seq
binding fragment
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JP2008509086A (ja
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グラハム シー． ペリー，
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アテニュオン， エルエルシー
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08—Vasodilators for multiple indications
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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JP2007515288A 2004-05-25 2005-05-25 下流ｕＰＡＲ相互作用を阻害するウロキナーゼ型プラスミノーゲン活性化因子（ｕＰＡ）とそのレセプター（ｕＰＡＲ）との複合体に結合するリガンド：診断または治療における同定および使用 Expired - Lifetime JP4890449B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57389604P 2004-05-25 2004-05-25
US60/573,896 2004-05-25
PCT/US2005/018322 WO2005116077A2 (en) 2004-05-25 2005-05-25 LIGANDS BINDING THE COMPLEX OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (uPA) AND ITS RECEPTOR (uPAR) THAT INHIBIT DOWNSTREAM uPAR INTERACTIONS: IDENTIFICATION AND USE IN DIAGNOSIS OR THERAPY

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JP2008509086A JP2008509086A (ja) 2008-03-27
JP2008509086A5 JP2008509086A5 (enExample) 2008-07-10
JP4890449B2 true JP4890449B2 (ja) 2012-03-07

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US (1) US8101726B2 (enExample)
EP (1) EP1765397B1 (enExample)
JP (1) JP4890449B2 (enExample)
KR (1) KR20070047246A (enExample)
CN (1) CN101022830A (enExample)
AU (1) AU2005248400A1 (enExample)
CA (1) CA2568428C (enExample)
DK (1) DK1765397T3 (enExample)
ES (1) ES2398221T3 (enExample)
IL (1) IL179565A0 (enExample)
MX (1) MXPA06013709A (enExample)
PL (1) PL1765397T3 (enExample)
PT (1) PT1765397E (enExample)
RU (1) RU2006145905A (enExample)
WO (1) WO2005116077A2 (enExample)
ZA (1) ZA200610578B (enExample)

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US8343489B2 (en) * 2006-03-21 2013-01-01 Weaver David T Methods for humanizing antibodies and humanized antibodies made thereby
CN1919874B (zh) * 2006-09-18 2010-09-08 中国人民解放军军事医学科学院生物工程研究所 一种抗尿激酶型纤溶酶激活剂受体的抗体样分子ATF-Fc融合蛋白及其用途
DK2117571T3 (en) * 2006-12-08 2017-05-08 Monopar Therapeutics Inc Urokinase-type plasminogen activator receptor epitope
US8815519B2 (en) * 2006-12-22 2014-08-26 Hvidovre Hospital Method for predicting cancer and other diseases
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2730282A1 (en) 2007-11-08 2014-05-14 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
EP2352503B1 (en) * 2008-11-06 2017-07-19 University of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
CN102597775A (zh) 2009-09-25 2012-07-18 佐马技术有限公司 筛选方法
CN103391787A (zh) 2010-12-22 2013-11-13 意大利癌症研究基金会分子肿瘤学研究所(Ifom) uPAR拮抗剂及其应用
WO2012097313A2 (en) 2011-01-14 2012-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
US20130344074A1 (en) 2011-03-16 2013-12-26 Sanofi Uses of a dual v region antibody-like protein
US9867923B2 (en) 2011-05-09 2018-01-16 University Of Miami Reducing soluble urokinase receptor in the circulation
AU2012293720A1 (en) 2011-08-05 2014-02-27 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Constitutively active uPAR variants and their use for the generation and isolation of inhibitory antibodies
PT3929207T (pt) * 2013-03-15 2024-10-21 Univ Texas Utilização do péptido fttftvt no tratamento de fibrose
CN105368859B (zh) * 2015-11-25 2019-10-18 王任直 一种嵌合抗原受体hCD87-CAR及载有hCD87-CAR基因结构的慢病毒及质粒及其应用
US10959062B1 (en) 2018-04-19 2021-03-23 Tango Tango, Inc. System and method for push-to-talk over cellular integration with software defined radio
US10681506B1 (en) 2018-04-19 2020-06-09 Tango Tango, Inc. System and method for push-to-talk over cellular integration with software defined radio
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis
WO2020069498A1 (en) 2018-09-28 2020-04-02 Jochen Reiser Supar and prediction and treatment of acute kidney injury
JP7774871B2 (ja) * 2019-10-28 2025-11-25 モナシュ ユニバーシティ プラスミンとの結合のための抗体
JP2023532426A (ja) * 2020-06-15 2023-07-28 モノパー セラピューティクス、インコーポレイテッド 重症ＣＯＶＩＤ－１９疾患の治療のためのウロキナーゼプラスミノーゲン活性化因子受容体（ｕＰＡＲ）の正確な放射線免疫治療標的化
IL306074A (en) 2021-03-24 2023-11-01 Alkermes Inc UPAR antibodies and fusion proteins with them
CA3223227A1 (en) * 2021-05-21 2022-11-24 NorthStar Medical Technologies, LLC Urokinase plasminogen activator receptor-targeted radiopharmaceutical
WO2022261398A1 (en) * 2021-06-11 2022-12-15 Memorial Sloan-Kettering Cancer Center Antigen recognizing receptors targeting upar and uses thereof
US20250197838A1 (en) * 2022-03-24 2025-06-19 The United States Government As Represented By The Department Of Veterans Affairs Urokinase-type plasminogen activator receptor binding peptides and methods of use
EP4610269A1 (en) 2024-02-29 2025-09-03 3B Pharmaceuticals GmbH Urokinase plasminogen activator surface receptor (upar) ligands for diagnostic or therapeutic use
WO2025207781A1 (en) 2024-03-26 2025-10-02 Monopar Therapeutics Inc. Antibody radioisotope constructs

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US5532132A (en) * 1993-09-28 1996-07-02 President And Fellows Of Harvard University Method for regulating formation of a complex of plasminogen activator, its receptor and inhibitor
DE10117381A1 (de) * 2001-04-06 2002-10-10 Wilex Biotechnology Gmbh Herstellung polyklonaler, monospezifischer Antikörper gegen die uPAR-Varianten del4, del5 und del4+5 sowie deren Verwendung für diagnostische und therapeutische Zwecke
US20030219837A1 (en) * 2002-03-18 2003-11-27 Cress Anne E. Integrin ligand
DK2117571T3 (en) * 2006-12-08 2017-05-08 Monopar Therapeutics Inc Urokinase-type plasminogen activator receptor epitope

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EP1765397A4 (en) 2009-05-13
PL1765397T3 (pl) 2013-04-30
CA2568428C (en) 2020-12-29
MXPA06013709A (es) 2008-01-16
AU2005248400A1 (en) 2005-12-08
JP2008509086A (ja) 2008-03-27
DK1765397T3 (da) 2013-02-04
IL179565A0 (en) 2007-05-15
PT1765397E (pt) 2013-02-04
EP1765397B1 (en) 2012-10-24
ES2398221T3 (es) 2013-03-14
RU2006145905A (ru) 2008-06-27
CN101022830A (zh) 2007-08-22
US8101726B2 (en) 2012-01-24
CA2568428A1 (en) 2005-12-08
US20090180952A1 (en) 2009-07-16
WO2005116077A3 (en) 2005-12-29
KR20070047246A (ko) 2007-05-04
EP1765397A2 (en) 2007-03-28
ZA200610578B (en) 2009-09-30
WO2005116077A2 (en) 2005-12-08

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