KR20070000663A - 신규한 아세틸도파민계 화합물, 및 선퇴 추출물 또는이로부터 분리된 아세틸도파민계 화합물을 유효성분으로함유하는 심장순환계 질환의 예방 및 치료용 조성물 - Google Patents
신규한 아세틸도파민계 화합물, 및 선퇴 추출물 또는이로부터 분리된 아세틸도파민계 화합물을 유효성분으로함유하는 심장순환계 질환의 예방 및 치료용 조성물 Download PDFInfo
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- KR20070000663A KR20070000663A KR1020050056188A KR20050056188A KR20070000663A KR 20070000663 A KR20070000663 A KR 20070000663A KR 1020050056188 A KR1020050056188 A KR 1020050056188A KR 20050056188 A KR20050056188 A KR 20050056188A KR 20070000663 A KR20070000663 A KR 20070000663A
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- South Korea
- Prior art keywords
- acetyldopamine
- extract
- composition
- compounds
- sesame
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- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
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Abstract
Description
시 료 | 저해도(%) 또는 IC50 (μM) |
선퇴 열수 추출물 (40 ㎍/㎖) | 45% 저해 |
선퇴 에탄올 추출물 (40 ㎍/㎖) | 60% 저해 |
n-헥산(40 ㎍/㎖) | 8% 저해 |
클로로포름(40 ㎍/㎖) | 11% 저해 |
에틸아세테이트(40 ㎍/㎖) | 85% 저해 |
화합물 1 | 2.1 μM |
화합물 2 | 1.5 μM |
양성대조군 (Probucol) | 3.6 μM |
Claims (10)
- 제 1항에 있어서, 상기 아세틸도파민계 화합물은 선퇴로부터 추출, 분리 및 정제하여 얻은 것임을 특징으로 하는 아세틸도파민계 화합물.
- (1) 선퇴에 물, 탄소수 1 내지 4의 저급 알콜 또는 이들의 혼합 용매로부터 선택된 용매를 첨가하여 조추출물을 제조하는 단계;(2) 상기 단계(1)에서 얻은 조추출물에 물을 가하여 현탁시키고, n-헥산, 클 로로포름 및 에틸아세테이트로 순차 분획하여 에틸아세테이트 가용추출물을 얻는 단계; 및(3) 상기 단계(2)에서 얻은 에틸아세테이트 가용추출물을 크로마토그래피로 분리, 정제하여 아세틸도파민계 화합물을 얻는 단계로 이루어지는 제 1항의 아세틸도파민계 화합물의 제조방법.
- 제 3항에 있어서, 상기 (1)단계에서 알콜은 메탄올, 에탄올 및 부탄올 중에서 선택된 것을 특징으로 하는 제 1항의 아세틸도파민계 화합물의 제조방법.
- 선퇴 추출물을 유효성분으로 하는 심장순환계 질환의 예방 및 치료용 조성물.
- 제 5항에 있어서, 상기 선퇴 추출물은 선퇴를 물, 메탄올, 에탄올, 부탄올 또는 이의 혼합 용매로부터 추출하여 얻은 것임을 특징으로 하는 심장순환계 질환의 예방 및 치료용 조성물.
- 제 6항에 있어서, 상기 선퇴 추출물은 선퇴의 에탄올 추출물인 것을 특징으로 하는 심장순환계 질환의 예방 및 치료용 조성물.
- 제 7항에 있어서, 상기 선퇴 추출물은 선퇴의 에탄올 추출물을 n-헥산, 클로로포름, 에틸아세테이트로 순차 분획하여 얻은 에틸아세테이트 가용추출물인 것을 특징으로 하는 심장순환계 질환의 예방 및 치료용 조성물.
- 제 5항 내지 제 9항 중 어느 한 항에 있어서, 상기 심장순환계 질환은 고지혈증 또는 동맥경화인 것을 특징으로 하는 심장순환계 질환의 예방 및 치료용 조성물.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020050056188A KR100758263B1 (ko) | 2005-06-28 | 2005-06-28 | 신규한 아세틸도파민계 화합물, 및 선퇴 추출물 또는이로부터 분리된 아세틸도파민계 화합물을 유효성분으로함유하는 심장순환계 질환의 예방 및 치료용 조성물 |
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CN110441459A (zh) * | 2019-08-27 | 2019-11-12 | 江苏卫生健康职业学院 | 一种蝉蜕中乙酰多巴胺的定性检测方法 |
CN114831312A (zh) * | 2022-04-24 | 2022-08-02 | 西北工业大学 | 一种由灵芝多糖和金蝉花多糖构成的中药组合物及应用 |
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CN110441459A (zh) * | 2019-08-27 | 2019-11-12 | 江苏卫生健康职业学院 | 一种蝉蜕中乙酰多巴胺的定性检测方法 |
CN114831312A (zh) * | 2022-04-24 | 2022-08-02 | 西北工业大学 | 一种由灵芝多糖和金蝉花多糖构成的中药组合物及应用 |
CN114831312B (zh) * | 2022-04-24 | 2023-10-24 | 西北工业大学 | 一种由灵芝多糖和金蝉花多糖构成的中药组合物及应用 |
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