KR20060129069A - 카스파제 억제제 및 이의 용도 - Google Patents
카스파제 억제제 및 이의 용도 Download PDFInfo
- Publication number
- KR20060129069A KR20060129069A KR1020067019903A KR20067019903A KR20060129069A KR 20060129069 A KR20060129069 A KR 20060129069A KR 1020067019903 A KR1020067019903 A KR 1020067019903A KR 20067019903 A KR20067019903 A KR 20067019903A KR 20060129069 A KR20060129069 A KR 20060129069A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- aliphatic
- carboxylic acid
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *[C@@](C(N(CCCCCC1)[C@@]1C(NC(C1)[C@@](O*)OC1=O)=O)=O)N* Chemical compound *[C@@](C(N(CCCCCC1)[C@@]1C(NC(C1)[C@@](O*)OC1=O)=O)=O)N* 0.000 description 18
- IJBGNKFVYKZBNU-XAYKYTGQSA-N CC(C)(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NC(c(cccc1O)c1Cl)=O Chemical compound CC(C)(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NC(c(cccc1O)c1Cl)=O IJBGNKFVYKZBNU-XAYKYTGQSA-N 0.000 description 1
- RXQDMVCJFZOPKS-JQBYSNGBSA-N CC(C)(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NC(c(cccc1OCC2CC2)c1Cl)O Chemical compound CC(C)(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NC(c(cccc1OCC2CC2)c1Cl)O RXQDMVCJFZOPKS-JQBYSNGBSA-N 0.000 description 1
- UQCHETQJZPBTAV-UHFFFAOYSA-N CC(C)C(C(N(C1CC2CC1)C2C(NC(CC(O)=O)C=O)=O)=O)NC(c(cccc1OC)c1F)=O Chemical compound CC(C)C(C(N(C1CC2CC1)C2C(NC(CC(O)=O)C=O)=O)=O)NC(c(cccc1OC)c1F)=O UQCHETQJZPBTAV-UHFFFAOYSA-N 0.000 description 1
- RKDIJDUANHCPKR-LIDKGGFZSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1C(NC(CCO)C=O)O)=O)NC(c(c(N)ccc1)c1Cl)O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1C(NC(CCO)C=O)O)=O)NC(c(c(N)ccc1)c1Cl)O RKDIJDUANHCPKR-LIDKGGFZSA-N 0.000 description 1
- AXZKGXZIJJFLBC-FTRWYGJKSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NCc(cccc1OC)c1Cl Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1C(N[C@@H](CC(O)=O)C=O)=O)=O)NCc(cccc1OC)c1Cl AXZKGXZIJJFLBC-FTRWYGJKSA-N 0.000 description 1
- GMYQMTNSRPVICT-ZKHUHEIGSA-N CC(C1C)C1(C(N(CCC1)[C@@H]1C(N[C@](C1)([C@@H]1C(O)=O)C=O)=O)=O)NC(c(cccc1Cl)c1Cl)=O Chemical compound CC(C1C)C1(C(N(CCC1)[C@@H]1C(N[C@](C1)([C@@H]1C(O)=O)C=O)=O)=O)NC(c(cccc1Cl)c1Cl)=O GMYQMTNSRPVICT-ZKHUHEIGSA-N 0.000 description 1
- QXCMXMYCUJDKJJ-UHFFFAOYSA-N CCN1C(C2)=CCC2C1N Chemical compound CCN1C(C2)=CCC2C1N QXCMXMYCUJDKJJ-UHFFFAOYSA-N 0.000 description 1
- PHQLSRCISUSWAU-JMZAEGDUSA-N CCO[C@@H](C(C1)NC([C@H]([C@@H](CC2)C[C@H]2C2)N2C([C@H](C(C)(C)C)NC(c2c(C)c(OC)ccc2)=O)=O)=O)OC1=O Chemical compound CCO[C@@H](C(C1)NC([C@H]([C@@H](CC2)C[C@H]2C2)N2C([C@H](C(C)(C)C)NC(c2c(C)c(OC)ccc2)=O)=O)=O)OC1=O PHQLSRCISUSWAU-JMZAEGDUSA-N 0.000 description 1
- LMMVTUNILVIEFV-QFXJDEEGSA-N CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)(C)C)NC(c2c(C)c(NC(C)=O)ccc2)=O)=O)=O)OC1O Chemical compound CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)(C)C)NC(c2c(C)c(NC(C)=O)ccc2)=O)=O)=O)OC1O LMMVTUNILVIEFV-QFXJDEEGSA-N 0.000 description 1
- MHMMBJSXNVSHBJ-LZTCXMBHSA-N CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)(C)C/[O]=C/c2c(C)c(NC(C)=O)ccc2)N)=O)=O)OC1=O Chemical compound CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)(C)C/[O]=C/c2c(C)c(NC(C)=O)ccc2)N)=O)=O)OC1=O MHMMBJSXNVSHBJ-LZTCXMBHSA-N 0.000 description 1
- SBEJBAHVKUYWHD-ZXVLUALBSA-N CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)C)NC(c(c(Cl)cnc2)c2Cl)=O)=O)=O)OC1O Chemical compound CCO[C@@H]([C@H](C1)NC([C@H](CCC2)N2C([C@H](C(C)C)NC(c(c(Cl)cnc2)c2Cl)=O)=O)=O)OC1O SBEJBAHVKUYWHD-ZXVLUALBSA-N 0.000 description 1
- STEFLYJOMUVBNF-OTCCDFFUSA-N CCO[C@H](C(C1)NC(C(C2CC3CC2)N3C(C(C(C)(C)C)NC(c(cccc2)c2Cl)=O)=O)=O)OC1=O Chemical compound CCO[C@H](C(C1)NC(C(C2CC3CC2)N3C(C(C(C)(C)C)NC(c(cccc2)c2Cl)=O)=O)=O)OC1=O STEFLYJOMUVBNF-OTCCDFFUSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K38/06—Tripeptides
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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| DK1064298T3 (da) * | 1998-03-19 | 2009-01-19 | Vertex Pharma | Inhibitorer af caspaser |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| CA2567080A1 (en) * | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| WO2011094426A1 (en) * | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| CN105853408B (zh) * | 2016-04-15 | 2018-12-04 | 浙江大学 | 苯酰胺衍生物在制备Caspase-1抑制剂中的应用 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| US20260062443A1 (en) * | 2022-08-23 | 2026-03-05 | Alexion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
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| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| KR100381584B1 (ko) * | 1994-07-22 | 2003-08-21 | 알타나 파마 아게 | 디히드로벤조푸란 |
| FI974437A7 (fi) * | 1995-06-06 | 1997-12-05 | Pfizer | Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina |
| KR20000036056A (ko) * | 1996-09-12 | 2000-06-26 | 아이디유엔 파마슈티칼즈, 인코포레이티드 | 인터루킨-1β 전환 효소 및 관련 프로테아제의 억제제로서의 C-말단 변형된 (N-치환된)-2-인돌릴 디펩티드 |
| EP0929311B8 (en) * | 1996-09-12 | 2006-02-01 | Idun Pharmaceuticals, Inc. | INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS |
| FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
| DK1064298T3 (da) * | 1998-03-19 | 2009-01-19 | Vertex Pharma | Inhibitorer af caspaser |
| US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| ES2322538T3 (es) | 1999-01-29 | 2009-06-23 | Senju Pharmaceutical Co., Ltd. | Inhibidores contra el aumento de la tension ocular causada por irradiacion con laseres, que contienen derivados de 1,4-dihidropiridina. |
| CA2402128A1 (en) | 2000-04-24 | 2001-11-01 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
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| TR200200767T1 (tr) | 2000-05-23 | 2002-09-23 | Vertex Pharmaceuticals Incorporated | Kaspaz engelleyiciler ve kullanımları |
| EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| WO2002022611A2 (en) | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
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2006
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| NO20064344L (no) | 2006-10-19 |
| RU2006134258A (ru) | 2008-04-10 |
| IL177709A0 (en) | 2006-12-31 |
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| TW201217332A (en) | 2012-05-01 |
| BRPI0508102A (pt) | 2007-07-17 |
| HK1099757A1 (en) | 2007-08-24 |
| HK1159614A1 (en) | 2012-08-03 |
| AR047981A1 (es) | 2006-03-15 |
| TW200540152A (en) | 2005-12-16 |
| US20050233979A1 (en) | 2005-10-20 |
| ZA200607634B (en) | 2008-01-08 |
| TWI362381B (en) | 2012-04-21 |
| NZ549665A (en) | 2010-09-30 |
| JP2011144203A (ja) | 2011-07-28 |
| JP2014140385A (ja) | 2014-08-07 |
| US7652153B2 (en) | 2010-01-26 |
| EP2270004A1 (en) | 2011-01-05 |
| RU2382780C2 (ru) | 2010-02-27 |
| WO2005085236A3 (en) | 2005-10-20 |
| AU2005219861A1 (en) | 2005-09-15 |
| CA2557645C (en) | 2013-09-24 |
| NO20064351L (no) | 2006-11-20 |
| US20100105914A1 (en) | 2010-04-29 |
| WO2005085236A2 (en) | 2005-09-15 |
| CN102161656A (zh) | 2011-08-24 |
| AU2005219861B2 (en) | 2011-08-11 |
| CA2557645A1 (en) | 2005-09-15 |
| CN102161656B (zh) | 2013-02-20 |
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