KR20060127413A - 항암제로서의 퀴나졸리논 화합물 - Google Patents

항암제로서의 퀴나졸리논 화합물 Download PDF

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Publication number
KR20060127413A
KR20060127413A KR1020067012603A KR20067012603A KR20060127413A KR 20060127413 A KR20060127413 A KR 20060127413A KR 1020067012603 A KR1020067012603 A KR 1020067012603A KR 20067012603 A KR20067012603 A KR 20067012603A KR 20060127413 A KR20060127413 A KR 20060127413A
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KR
South Korea
Prior art keywords
substituted
oxo
chloro
dihydroquinazolin
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020067012603A
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English (en)
Korean (ko)
Inventor
웨이보 왕
리아나 엠. 라그니톤
라이언 엔. 콘스탄틴
마노즈 씨. 데사이
Original Assignee
카이론 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 카이론 코포레이션 filed Critical 카이론 코포레이션
Publication of KR20060127413A publication Critical patent/KR20060127413A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020067012603A 2003-11-25 2004-11-24 항암제로서의 퀴나졸리논 화합물 Withdrawn KR20060127413A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52505903P 2003-11-25 2003-11-25
US60/525,059 2003-11-25

Publications (1)

Publication Number Publication Date
KR20060127413A true KR20060127413A (ko) 2006-12-12

Family

ID=34632957

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067012603A Withdrawn KR20060127413A (ko) 2003-11-25 2004-11-24 항암제로서의 퀴나졸리논 화합물

Country Status (17)

Country Link
US (2) US7939539B2 (https=)
EP (1) EP1689724B1 (https=)
JP (2) JP4778439B2 (https=)
KR (1) KR20060127413A (https=)
CN (1) CN1886384A (https=)
AT (1) ATE538103T1 (https=)
AU (1) AU2004293464A1 (https=)
CA (1) CA2546932A1 (https=)
CY (1) CY1112478T1 (https=)
DK (1) DK1689724T3 (https=)
ES (1) ES2376552T3 (https=)
IL (1) IL175714A0 (https=)
PL (1) PL1689724T3 (https=)
PT (1) PT1689724E (https=)
SG (1) SG148202A1 (https=)
SI (1) SI1689724T1 (https=)
WO (1) WO2005051922A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100916160B1 (ko) * 2007-02-21 2009-09-08 (주)바이오버드 약제학적 항암 조성물

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US20080064680A1 (en) * 2004-09-14 2008-03-13 Bamdad Cynthia C Methods for Diagnosis and Treatment of Cancer
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WO2009102537A1 (en) * 2008-02-14 2009-08-20 Merck & Co., Inc. Inhibitors of checkpoint kinases
CN101250189B (zh) * 2008-03-25 2010-06-16 中山大学 双脂肪氨基取代喹唑酮衍生物及其制备方法与作为抗癌药物的应用
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CN101857595B (zh) * 2010-05-21 2012-11-21 中山大学 一种喹唑酮衍生物及其制备方法和作为抗癌药物的用途
CN101899009B (zh) * 2010-07-30 2012-04-04 江苏昊华精细化工有限公司 医药中间体4(h)喹唑酮的制造方法
CN101967127B (zh) * 2010-09-28 2013-05-29 中山大学 一种喹唑啉衍生物及其制备方法和制备抗癌药物中的应用
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CN103012291B (zh) * 2012-12-17 2014-09-03 中山大学 一种2-苯基喹唑啉衍生物及其制备方法与在制备抗癌药物中的应用
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US9550796B2 (en) 2013-11-21 2017-01-24 Novartis Ag Pyrrolopyrrolone derivatives and their use as BET inhibitors
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US11071788B2 (en) 2015-06-23 2021-07-27 Bayer Pharma Aktiengesellschaft Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
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TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート（ａｄｃ）
JP7030811B2 (ja) 2016-12-21 2022-03-07 バイエル・ファルマ・アクティエンゲゼルシャフト Ｋｓｐ阻害剤を有する特異的抗体－薬物コンジュゲート（ａｄｃ）
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CN111499634B (zh) * 2019-01-31 2023-05-12 贝达药业股份有限公司 一种喹唑啉化合物及其在医药上的应用
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KR102682775B1 (ko) 2020-06-26 2024-07-08 홀로스메딕 주식회사 신규한 화합물의 제조방법
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KR102862736B1 (ko) * 2022-12-07 2025-09-22 부산대학교 산학협력단 신규 2-((트랜스-4-(4-아릴옥시)사이클로헥실)아미노)퀴나졸리논 유도체 및 이의 제조방법

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* Cited by examiner, † Cited by third party
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KR100916160B1 (ko) * 2007-02-21 2009-09-08 (주)바이오버드 약제학적 항암 조성물

Also Published As

Publication number Publication date
PT1689724E (pt) 2012-02-06
JP2011084570A (ja) 2011-04-28
EP1689724A1 (en) 2006-08-16
ATE538103T1 (de) 2012-01-15
IL175714A0 (en) 2006-09-05
DK1689724T3 (da) 2012-02-27
WO2005051922A1 (en) 2005-06-09
US20050209254A1 (en) 2005-09-22
CA2546932A1 (en) 2005-06-09
JP4778439B2 (ja) 2011-09-21
CY1112478T1 (el) 2015-12-09
SI1689724T1 (sl) 2012-04-30
US7939539B2 (en) 2011-05-10
US20110190293A1 (en) 2011-08-04
ES2376552T3 (es) 2012-03-14
AU2004293464A1 (en) 2005-06-09
EP1689724B1 (en) 2011-12-21
SG148202A1 (en) 2008-12-31
JP2007512368A (ja) 2007-05-17
CN1886384A (zh) 2006-12-27
PL1689724T3 (pl) 2012-05-31

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PA0105 International application

Patent event date: 20060623

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid