KR20060100412A - 비만, 당뇨, 우울증 및 불안증을 치료하기 위한 ｍｃｈｒ１ 길항제로서의 3-(4-아미노페닐)티에노피리미드-4-온유도체 - Google Patents
비만, 당뇨, 우울증 및 불안증을 치료하기 위한 ｍｃｈｒ１ 길항제로서의 3-(4-아미노페닐)티에노피리미드-4-온유도체 Download PDFInfo
- Publication number
- KR20060100412A KR20060100412A KR1020067009417A KR20067009417A KR20060100412A KR 20060100412 A KR20060100412 A KR 20060100412A KR 1020067009417 A KR1020067009417 A KR 1020067009417A KR 20067009417 A KR20067009417 A KR 20067009417A KR 20060100412 A KR20060100412 A KR 20060100412A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- alkyl
- group
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C1C)C(**)=*C(C=C(C)*2)=C2C1=O Chemical compound CC(C1C)C(**)=*C(C=C(C)*2)=C2C1=O 0.000 description 2
- JOAYEJZDGOLEDZ-KRWDZBQOSA-N COc1cc(N(C=Nc2c3[s]c(-c(cc4)ccc4Cl)c2)C3=O)ccc1N(CC1)C[C@H]1O Chemical compound COc1cc(N(C=Nc2c3[s]c(-c(cc4)ccc4Cl)c2)C3=O)ccc1N(CC1)C[C@H]1O JOAYEJZDGOLEDZ-KRWDZBQOSA-N 0.000 description 1
- AANASIBFBCHEMB-UHFFFAOYSA-N COc1cc(N(C=Nc2c3[s]c(-c(cc4)ccc4F)c2)C3=O)ccc1N(CC1)CCC1O Chemical compound COc1cc(N(C=Nc2c3[s]c(-c(cc4)ccc4F)c2)C3=O)ccc1N(CC1)CCC1O AANASIBFBCHEMB-UHFFFAOYSA-N 0.000 description 1
- XYXOJCPATRPBDH-UHFFFAOYSA-N OCC(CCC1)CN1c(cc1)ccc1N(C=Nc1c2[s]c(-c(cc3)ccc3Cl)c1)C2=O Chemical compound OCC(CCC1)CN1c(cc1)ccc1N(C=Nc1c2[s]c(-c(cc3)ccc3Cl)c1)C2=O XYXOJCPATRPBDH-UHFFFAOYSA-N 0.000 description 1
- LLUXGIQLIWAGQN-UHFFFAOYSA-N OCc(cc(cc1)N(C=Nc2c3[s]c(-c(cc4)ccc4Cl)c2)C3=O)c1N1CCCC1 Chemical compound OCc(cc(cc1)N(C=Nc2c3[s]c(-c(cc4)ccc4Cl)c2)C3=O)c1N1CCCC1 LLUXGIQLIWAGQN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51380003P | 2003-10-23 | 2003-10-23 | |
| US60/513,800 | 2003-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060100412A true KR20060100412A (ko) | 2006-09-20 |
Family
ID=34549304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067009417A Withdrawn KR20060100412A (ko) | 2003-10-23 | 2004-10-21 | 비만, 당뇨, 우울증 및 불안증을 치료하기 위한 ｍｃｈｒ１ 길항제로서의 3-(4-아미노페닐)티에노피리미드-4-온유도체 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070078125A1 (https=) |
| EP (1) | EP1678184A1 (https=) |
| JP (1) | JP2007509158A (https=) |
| KR (1) | KR20060100412A (https=) |
| CN (1) | CN1871242A (https=) |
| AU (1) | AU2004285913A1 (https=) |
| BR (1) | BRPI0415667A (https=) |
| CA (1) | CA2543122A1 (https=) |
| CO (1) | CO5690599A2 (https=) |
| IL (1) | IL174693A0 (https=) |
| MA (1) | MA28111A1 (https=) |
| MX (1) | MXPA06003997A (https=) |
| NO (1) | NO20061909L (https=) |
| WO (1) | WO2005042541A1 (https=) |
| ZA (1) | ZA200603181B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015535A3 (ko) * | 2011-07-27 | 2013-04-11 | 한국보건산업진흥원 | 신규 피리미딘 유도체 및 이를 활성성분으로 포함하는 약학 조성물 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009501217A (ja) * | 2005-07-15 | 2009-01-15 | アストラゼネカ アクチボラグ | 治療薬 |
| ATE429428T1 (de) | 2005-09-30 | 2009-05-15 | Hoffmann La Roche | Indanderivate als antagonisten des mch-rezeptors |
| AR056155A1 (es) * | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
| US7745447B2 (en) | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
| CA2626220A1 (en) | 2005-12-21 | 2007-06-28 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
| US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
| WO2007093364A1 (en) | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| BRPI0707869A2 (pt) | 2006-02-15 | 2011-05-10 | Sanofi Aventis | ariltienopirimidinonas substituÍdas com azaciclil, processo para a sua preparaÇço e seus usos como medicamentos |
| KR20080094699A (ko) | 2006-02-15 | 2008-10-23 | 사노피-아벤티스 | 신규 아미노알콜-치환된 아릴디하이드로이소퀴놀리논, 이의제조 방법 및 이의 약물로서의 용도 |
| WO2007093365A2 (en) | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
| EA015127B1 (ru) * | 2006-06-08 | 2011-06-30 | Эли Лилли Энд Компани | Антагонисты мсн-рецепторов |
| JP2010501553A (ja) * | 2006-08-18 | 2010-01-21 | アストラゼネカ アクチボラグ | Ｍｃｈｒ１アンタゴニストとしてのチエノピリミジン−４−オン誘導体およびチエノピリダジン−７−オン誘導体 |
| NZ578096A (en) | 2007-01-10 | 2011-11-25 | Albany Molecular Res Inc | 5-pyridinone substituted indazoles |
| US7851622B2 (en) | 2007-04-25 | 2010-12-14 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists |
| CN101861311A (zh) | 2007-07-21 | 2010-10-13 | 阿尔巴尼分子研究公司 | 5-吡啶酮取代的吲唑 |
| PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
| EP2406233B1 (en) * | 2009-03-09 | 2013-11-13 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| PL2747693T3 (pl) | 2011-08-26 | 2018-09-28 | On Light Sciences, Inc. | Układ i sposób usuwania tatuaży |
| EP4076527A4 (en) * | 2020-01-10 | 2024-05-15 | Consynance Therapeutics, Inc. | Therapeutic combinations of drugs and methods of using them |
| HUP2200222A1 (hu) | 2022-06-17 | 2023-12-28 | Richter Gedeon Nyrt | MCHR1 antagonisták a Prader-Willi szindróma kezelésére |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
-
2004
- 2004-10-21 JP JP2006536779A patent/JP2007509158A/ja active Pending
- 2004-10-21 CN CNA2004800313000A patent/CN1871242A/zh active Pending
- 2004-10-21 MX MXPA06003997A patent/MXPA06003997A/es unknown
- 2004-10-21 US US10/576,765 patent/US20070078125A1/en not_active Abandoned
- 2004-10-21 WO PCT/US2004/034846 patent/WO2005042541A1/en not_active Ceased
- 2004-10-21 CA CA002543122A patent/CA2543122A1/en not_active Abandoned
- 2004-10-21 KR KR1020067009417A patent/KR20060100412A/ko not_active Withdrawn
- 2004-10-21 EP EP04795941A patent/EP1678184A1/en not_active Withdrawn
- 2004-10-21 AU AU2004285913A patent/AU2004285913A1/en not_active Abandoned
- 2004-10-21 BR BRPI0415667-6A patent/BRPI0415667A/pt not_active IP Right Cessation
-
2006
- 2006-03-30 IL IL174693A patent/IL174693A0/en unknown
- 2006-04-20 ZA ZA200603181A patent/ZA200603181B/en unknown
- 2006-04-21 CO CO06038136A patent/CO5690599A2/es not_active Application Discontinuation
- 2006-04-25 MA MA28965A patent/MA28111A1/fr unknown
- 2006-04-28 NO NO20061909A patent/NO20061909L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015535A3 (ko) * | 2011-07-27 | 2013-04-11 | 한국보건산업진흥원 | 신규 피리미딘 유도체 및 이를 활성성분으로 포함하는 약학 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070078125A1 (en) | 2007-04-05 |
| JP2007509158A (ja) | 2007-04-12 |
| MXPA06003997A (es) | 2006-07-05 |
| CO5690599A2 (es) | 2006-10-31 |
| AU2004285913A1 (en) | 2005-05-12 |
| BRPI0415667A (pt) | 2006-12-19 |
| NO20061909L (no) | 2006-05-03 |
| IL174693A0 (en) | 2006-08-20 |
| ZA200603181B (en) | 2008-01-30 |
| MA28111A1 (fr) | 2006-08-01 |
| WO2005042541A1 (en) | 2005-05-12 |
| CA2543122A1 (en) | 2005-05-12 |
| EP1678184A1 (en) | 2006-07-12 |
| CN1871242A (zh) | 2006-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20060515 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |