KR20060072603A - α-리포산 함유 간질환 예방 또는 치료용 조성물 - Google Patents
α-리포산 함유 간질환 예방 또는 치료용 조성물 Download PDFInfo
- Publication number
- KR20060072603A KR20060072603A KR1020040111283A KR20040111283A KR20060072603A KR 20060072603 A KR20060072603 A KR 20060072603A KR 1020040111283 A KR1020040111283 A KR 1020040111283A KR 20040111283 A KR20040111283 A KR 20040111283A KR 20060072603 A KR20060072603 A KR 20060072603A
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- South Korea
- Prior art keywords
- liver
- composition
- lipoic acid
- selenium
- carbon tetrachloride
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
처리 | OD | TBARS(nM) | |
제1군 | 정상 | 0.682±0.02 | 3.136±0.08 |
제2군 | CCl4 | 0.732±0.03 | 3.362±0.16 |
제3군 | 실리마린 | 0.614±0.01 | 2.826±0.06* |
제4군 | HS0406 200 ㎎ | 0.588±0.02 | 2.707±0.09* |
제5군 | HS0406 800 ㎎ | 0.572±0.04 | 2.637±0.17** |
Claims (8)
- 유효성분으로서, α-리포산(α-lipoic acid), 비타민 및 셀레늄을 함유하는, 간질환 예방 또는 치료, 간기능 개선 또는 간보호용 조성물.
- 제1항에 있어서, α-리포산, 비타민 및 셀레늄을 0.005∼30:0.01∼60:1의 중량비로 함유하는 조성물.
- 제1항에 있어서, 비타민은 아스코르브산, 토코페롤, 또는 이들의 혼합물인 조성물.
- 유효성분으로서, α-리포산, 아스코르브산, 토코페롤 및 셀레늄을 함유하는, 간질환 예방 또는 치료, 간기능 개선 또는 간보호용 조성물.
- 제4항에 있어서, α-리포산, 아스코르브산, 토코페롤 및 셀레늄을 0.005∼30:0.005∼30:0.005∼30:1의 중량비로 함유하는 조성물.
- 제1항 내지 제5항 중 어느 한 항에 있어서, 추가로 약제학적으로 허용되는 담체를 함유하는 조성물.
- 제1항 내지 제5항 중 어느 한 항에 있어서, 추가로 아미노산 제제 또는 간장추출물을 함유하는 조성물.
- 제1항 내지 제5항 중 어느 한 항에 있어서, 지방간, 간 섬유증, 간경변 또는 바이러스 또는 약물로 인한 간염으로부터 선택되는 급·만성 간질환 예방 또는 치료용 조성물.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040111283A KR100653877B1 (ko) | 2004-12-23 | 2004-12-23 | α-리포산 함유 간질환 예방 또는 치료용 조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020040111283A KR100653877B1 (ko) | 2004-12-23 | 2004-12-23 | α-리포산 함유 간질환 예방 또는 치료용 조성물 |
Publications (2)
Publication Number | Publication Date |
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KR20060072603A true KR20060072603A (ko) | 2006-06-28 |
KR100653877B1 KR100653877B1 (ko) | 2006-12-05 |
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KR1020040111283A KR100653877B1 (ko) | 2004-12-23 | 2004-12-23 | α-리포산 함유 간질환 예방 또는 치료용 조성물 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010083277A3 (en) * | 2009-01-14 | 2011-01-06 | Hill's Pet Nutrition, Inc. | Methods for improving hepatic and immune function in an animal |
KR20180126772A (ko) | 2017-05-18 | 2018-11-28 | 엄태경 | 당구 게임 자동 매칭 시스템 및 이를 이용한 방법 |
WO2019124607A1 (ko) * | 2017-12-22 | 2019-06-27 | 경상대학교병원 | α-리포산, 에보글립틴 또는 이의 혼합물을 유효성분으로 함유하는 비알콜성 지방간 질환의 예방 또는 치료용 약학 조성물 |
WO2020138557A1 (ko) * | 2018-12-28 | 2020-07-02 | 경상대학교병원 | 지방간 예방 또는 치료용 약학적 조성물 및 건강기능식품 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284786B1 (en) * | 1999-02-16 | 2001-09-04 | The Center For The Improvement Of Human Functioning, Int'l., Inc. | Treatment of cancer using lipoic acid in combination with ascorbic acid |
US6420342B1 (en) | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
US6585998B2 (en) | 2001-11-13 | 2003-07-01 | Rudolph Cartwright | Nutraceutical composition |
-
2004
- 2004-12-23 KR KR1020040111283A patent/KR100653877B1/ko active IP Right Grant
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010083277A3 (en) * | 2009-01-14 | 2011-01-06 | Hill's Pet Nutrition, Inc. | Methods for improving hepatic and immune function in an animal |
JP2012515211A (ja) * | 2009-01-14 | 2012-07-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物において肝および免疫機能を向上させるための方法 |
AU2010204766B2 (en) * | 2009-01-14 | 2013-01-31 | Hill's Pet Nutrition, Inc. | Methods for improving hepatic and immune function in an animal |
RU2485797C2 (ru) * | 2009-01-14 | 2013-06-27 | Хилл'С Пет Ньютришн, Инк. | Способы улучшения функционирования печени и иммунной системы у животного |
KR20180126772A (ko) | 2017-05-18 | 2018-11-28 | 엄태경 | 당구 게임 자동 매칭 시스템 및 이를 이용한 방법 |
WO2019124607A1 (ko) * | 2017-12-22 | 2019-06-27 | 경상대학교병원 | α-리포산, 에보글립틴 또는 이의 혼합물을 유효성분으로 함유하는 비알콜성 지방간 질환의 예방 또는 치료용 약학 조성물 |
WO2020138557A1 (ko) * | 2018-12-28 | 2020-07-02 | 경상대학교병원 | 지방간 예방 또는 치료용 약학적 조성물 및 건강기능식품 |
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KR100653877B1 (ko) | 2006-12-05 |
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