KR20060014048A - 퇴행성 디스크 질환을 치료하는 방법 - Google Patents

퇴행성 디스크 질환을 치료하는 방법 Download PDF

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Publication number
KR20060014048A
KR20060014048A KR1020057021572A KR20057021572A KR20060014048A KR 20060014048 A KR20060014048 A KR 20060014048A KR 1020057021572 A KR1020057021572 A KR 1020057021572A KR 20057021572 A KR20057021572 A KR 20057021572A KR 20060014048 A KR20060014048 A KR 20060014048A
Authority
KR
South Korea
Prior art keywords
antagonist
formulation
tnf
disc
high specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020057021572A
Other languages
English (en)
Korean (ko)
Inventor
하쎈 세란
토마스 엠 디모로
모하메드 애타위아
멜리사 그레이스
수드하카르 카디얄라
데이비드 우르반스
스코트 브루더
그레고리 콜린스
로라 제이 브라운
제프 게신
파멜라 엘 플로우하르
캐써린 스미쓰
존 시키어카
Original Assignee
디퍼이 스파인 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/456,948 external-priority patent/US7344716B2/en
Priority claimed from US10/610,355 external-priority patent/US7429378B2/en
Priority claimed from US10/631,487 external-priority patent/US20040229878A1/en
Priority claimed from US10/640,412 external-priority patent/US7553827B2/en
Application filed by 디퍼이 스파인 인코포레이티드 filed Critical 디퍼이 스파인 인코포레이티드
Publication of KR20060014048A publication Critical patent/KR20060014048A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/38Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020057021572A 2003-05-13 2004-05-13 퇴행성 디스크 질환을 치료하는 방법 Withdrawn KR20060014048A (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US47009803P 2003-05-13 2003-05-13
US60/470,098 2003-05-13
US10/456,948 US7344716B2 (en) 2003-05-13 2003-06-06 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US10/456,948 2003-06-06
US10/610,355 US7429378B2 (en) 2003-05-13 2003-06-30 Transdiscal administration of high affinity anti-MMP inhibitors
US10/610,355 2003-06-30
US10/631,487 US20040229878A1 (en) 2003-05-13 2003-07-31 Transdiscal administration of specific inhibitors of P38 kinase
US10/631,487 2003-07-31
US10/640,412 2003-08-13
US10/640,412 US7553827B2 (en) 2003-08-13 2003-08-13 Transdiscal administration of cycline compounds

Publications (1)

Publication Number Publication Date
KR20060014048A true KR20060014048A (ko) 2006-02-14

Family

ID=33556747

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057021572A Withdrawn KR20060014048A (ko) 2003-05-13 2004-05-13 퇴행성 디스크 질환을 치료하는 방법

Country Status (8)

Country Link
EP (2) EP1631266B1 (enExample)
JP (1) JP2007502327A (enExample)
KR (1) KR20060014048A (enExample)
AU (1) AU2004251042A1 (enExample)
BR (1) BRPI0410331A (enExample)
CA (1) CA2525928A1 (enExample)
MX (1) MXPA05012275A (enExample)
WO (1) WO2005000283A2 (enExample)

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US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
CN100394989C (zh) 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US20050100538A1 (en) * 2003-07-31 2005-05-12 Attawia Mohamed Intradiscal injection of anti-oxidants
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
EP1931328A4 (en) * 2005-08-16 2011-07-13 Discogen Llc METHOD FOR TREATING A GREENER SUBJECT WITH DEGENERATIVE DISCOPATHY USING AN INHIBITOR OF NITRIC OXIDE SYNTHASE
CA2862540C (en) * 2005-09-21 2018-07-31 The Regents Of The University Of California Systems, compositions, and methods for local imaging and treatment of pain
EP1986657A4 (en) * 2006-02-16 2011-07-20 Discogen Llc METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISCOPATHY BY A MATRIX METALLOPROTEASE INHIBITOR
US8118779B2 (en) 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US8399619B2 (en) 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
EP2323997B1 (en) 2008-07-31 2017-09-06 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
EP3439691A4 (en) * 2016-04-04 2020-05-13 GU Ventures AB METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIA
WO2019060869A1 (en) 2017-09-25 2019-03-28 Discitisdx, Inc. METHODS FOR TREATING DEGENERATIVE DISC DISEASE AND CHRONIC LOMBALGIA
EP3746393A4 (en) * 2018-02-02 2021-11-03 Galen Therapeutics Llc DEVICE AND METHOD FOR PROTECTING NEURONS AND REDUCING INFLAMMATION AND SCARING
CN112703193A (zh) 2018-08-07 2021-04-23 弗门尼舍公司 5-取代的4-氨基-1H-苯并[c][1,2,6]噻二嗪2,2-二氧化物及其制剂和用途
CN110613837A (zh) * 2019-10-24 2019-12-27 内蒙古医科大学第二附属医院 TGF-β在制备预防或治疗腰椎间盘突出药物中的应用

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DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
JP2647427B2 (ja) 1987-04-24 1997-08-27 帝人株式会社 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット
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Also Published As

Publication number Publication date
EP1631266A2 (en) 2006-03-08
WO2005000283A3 (en) 2005-08-11
JP2007502327A (ja) 2007-02-08
BRPI0410331A (pt) 2006-05-30
AU2004251042A1 (en) 2005-01-06
EP1631266B1 (en) 2011-03-16
CA2525928A1 (en) 2005-01-06
EP2286804A1 (en) 2011-02-23
WO2005000283A2 (en) 2005-01-06
AU2004251042A2 (en) 2005-01-06
MXPA05012275A (es) 2006-02-10

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20051111

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid