KR20050113612A

KR20050113612A - 인돌리논 화합물을 사용한 과도한 골 용해의 치료

인돌리논 화합물을 사용한 과도한 골 용해의 치료 Download PDF

Info

Publication number: KR20050113612A
Authority: KR; South Korea
Prior art keywords: group; alkyl; heteroaryl; aryl; compound
Prior art date: 2003-02-24
Legal status : Withdrawn

Application number

KR1020057015602A

Other languages

English (en)

Korean (ko)

Inventor

레슬리 뮤레이

앤-마리 오파렐

틴야 아브람스

Original Assignee

수젠, 인크.

Priority date

2003-02-24

Filing date

2004-02-23

Publication date

2005-12-02

2004-02-23 Application filed by 수젠, 인크. filed Critical 수젠, 인크.

2005-12-02 Publication of KR20050113612A publication Critical patent/KR20050113612A/ko

Status Withdrawn legal-status Critical Current

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JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title description 7
150000001875 compounds Chemical class 0.000 claims abstract description 108
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230000002401 inhibitory effect Effects 0.000 claims abstract description 11
230000026731 phosphorylation Effects 0.000 claims abstract description 11
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238000000034 method Methods 0.000 claims description 66
-1 amino, monosubstituted amino Chemical group 0.000 claims description 55
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125000001072 heteroaryl group Chemical group 0.000 claims description 50
125000003545 alkoxy group Chemical group 0.000 claims description 46
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125000000623 heterocyclic group Chemical group 0.000 claims description 41
229910052757 nitrogen Inorganic materials 0.000 claims description 30
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229910052739 hydrogen Inorganic materials 0.000 claims description 25
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229910052799 carbon Inorganic materials 0.000 claims description 22
239000001257 hydrogen Substances 0.000 claims description 21
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125000006413 ring segment Chemical group 0.000 claims description 12
125000001188 haloalkyl group Chemical group 0.000 claims description 9
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CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 9
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
208000001132 Osteoporosis Diseases 0.000 claims description 7
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PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 5
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