AU2004216188A1

AU2004216188A1 - Treatment of excessive osteolyisis with indolinone compounds

Treatment of excessive osteolyisis with indolinone compounds Download PDF

Info

Publication number: AU2004216188A1
Authority: AU; Australia
Prior art keywords: group; compound; alkyl; heteroaryl; aryl
Prior art date: 2003-02-24
Legal status : Abandoned

Application number

AU2004216188A

Other languages

English (en)

Inventor

Tinya Abrams

Lesley Murray

Anne-Marie O'farrell

Current Assignee

Sugen LLC

Original Assignee

Sugen LLC

Priority date

2003-02-24

Filing date

2004-02-23

Publication date

2004-09-10

2004-02-23 Application filed by Sugen LLC filed Critical Sugen LLC

2004-09-10 Publication of AU2004216188A1 publication Critical patent/AU2004216188A1/en

Status Abandoned legal-status Critical Current

Links

238000011282 treatment Methods 0.000 title description 13
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title description 7
150000001875 compounds Chemical class 0.000 claims description 115
125000000217 alkyl group Chemical group 0.000 claims description 107
238000000034 method Methods 0.000 claims description 63
125000003118 aryl group Chemical group 0.000 claims description 56
125000001072 heteroaryl group Chemical group 0.000 claims description 51
125000003545 alkoxy group Chemical group 0.000 claims description 49
206010028980 Neoplasm Diseases 0.000 claims description 46
125000000623 heterocyclic group Chemical group 0.000 claims description 44
125000000753 cycloalkyl group Chemical group 0.000 claims description 41
-1 amino, monosubstituted amino Chemical group 0.000 claims description 39
208000003076 Osteolysis Diseases 0.000 claims description 32
208000029791 lytic metastatic bone lesion Diseases 0.000 claims description 32
210000000988 bone and bone Anatomy 0.000 claims description 31
229910052757 nitrogen Inorganic materials 0.000 claims description 31
229940125904 compound 1 Drugs 0.000 claims description 30
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 27
229910052739 hydrogen Inorganic materials 0.000 claims description 27
201000011510 cancer Diseases 0.000 claims description 25
229910052799 carbon Inorganic materials 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 21
239000001257 hydrogen Substances 0.000 claims description 20
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