NZ541825A - Treatment of excessive osteolysis with indolinone compounds - Google Patents

Info

Publication number

NZ541825A

NZ541825A NZ541825A NZ54182504A NZ541825A NZ 541825 A NZ541825 A NZ 541825A NZ 541825 A NZ541825 A NZ 541825A NZ 54182504 A NZ54182504 A NZ 54182504A NZ 541825 A NZ541825 A NZ 541825A

Authority

NZ

New Zealand

Prior art keywords

group

alkyl

heteroaryl

aryl

cycloalkyl

Prior art date

2003-02-24

Links

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• Global Dossier
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• 208000003076 Osteolysis Diseases 0.000 title claims abstract description 34
• 208000029791 lytic metastatic bone lesion Diseases 0.000 title claims abstract description 34
• 238000011282 treatment Methods 0.000 title description 13
• JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 107
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 47
• 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims abstract description 21
• 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims abstract description 21
• 239000003814 drug Substances 0.000 claims abstract description 20
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• 230000026731 phosphorylation Effects 0.000 claims abstract description 11
• 238000006366 phosphorylation reaction Methods 0.000 claims abstract description 11
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 9
• 238000004519 manufacturing process Methods 0.000 claims abstract description 5
• 125000000217 alkyl group Chemical group 0.000 claims description 108
• 125000003118 aryl group Chemical group 0.000 claims description 57
• 125000001072 heteroaryl group Chemical group 0.000 claims description 53
• 125000003545 alkoxy group Chemical group 0.000 claims description 50
• 125000000623 heterocyclic group Chemical group 0.000 claims description 44
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 42
• -1 hetercyclic Chemical group 0.000 claims description 37
• 210000000988 bone and bone Anatomy 0.000 claims description 31
• 229910052757 nitrogen Inorganic materials 0.000 claims description 29
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 24
• 229910052760 oxygen Inorganic materials 0.000 claims description 23
• 150000003839 salts Chemical class 0.000 claims description 21
• 229910052717 sulfur Inorganic materials 0.000 claims description 21
• 229910052799 carbon Inorganic materials 0.000 claims description 20
• 239000001257 hydrogen Substances 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
• 125000006413 ring segment Chemical group 0.000 claims description 13
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
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• 125000001475 halogen functional group Chemical group 0.000 claims 3
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• 125000004093 cyano group Chemical group *C#N 0.000 description 10
• 125000004385 trihaloalkyl group Chemical group 0.000 description 10
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• 125000002252 acyl group Chemical group 0.000 description 8
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• 125000005842 heteroatom Chemical group 0.000 description 8
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
• 230000009401 metastasis Effects 0.000 description 8
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