KR20050084094A - 골 대용품으로서의 시멘트 제제를 위한 조성물 - Google Patents
골 대용품으로서의 시멘트 제제를 위한 조성물 Download PDFInfo
- Publication number
- KR20050084094A KR20050084094A KR1020057009928A KR20057009928A KR20050084094A KR 20050084094 A KR20050084094 A KR 20050084094A KR 1020057009928 A KR1020057009928 A KR 1020057009928A KR 20057009928 A KR20057009928 A KR 20057009928A KR 20050084094 A KR20050084094 A KR 20050084094A
- Authority
- KR
- South Korea
- Prior art keywords
- cement
- formulation
- bone
- additive
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000004568 cement Substances 0.000 title claims description 105
- 239000000203 mixture Substances 0.000 title claims description 85
- 238000009472 formulation Methods 0.000 title claims description 55
- 238000002360 preparation method Methods 0.000 title claims description 18
- 239000000316 bone substitute Substances 0.000 title claims description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 52
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 51
- 239000000843 powder Substances 0.000 claims abstract description 35
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 33
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 32
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 23
- 239000002639 bone cement Substances 0.000 claims abstract description 5
- 239000000654 additive Substances 0.000 claims description 43
- 230000000996 additive effect Effects 0.000 claims description 23
- 229910052751 metal Inorganic materials 0.000 claims description 22
- 239000002184 metal Substances 0.000 claims description 20
- 239000011777 magnesium Substances 0.000 claims description 19
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 18
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 18
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 15
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 159000000009 barium salts Chemical class 0.000 claims description 11
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 11
- 230000007547 defect Effects 0.000 claims description 10
- 230000002708 enhancing effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 10
- 229910052761 rare earth metal Inorganic materials 0.000 claims description 10
- 239000011575 calcium Substances 0.000 claims description 9
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 8
- 150000002736 metal compounds Chemical class 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 235000021317 phosphate Nutrition 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 7
- 239000010452 phosphate Substances 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- 229910052742 iron Inorganic materials 0.000 claims description 6
- 150000002739 metals Chemical class 0.000 claims description 6
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical group [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 5
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 5
- 150000002497 iodine compounds Chemical class 0.000 claims description 5
- 150000002506 iron compounds Chemical class 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 229910044991 metal oxide Inorganic materials 0.000 claims description 5
- 150000004706 metal oxides Chemical class 0.000 claims description 5
- 150000005527 organic iodine compounds Chemical class 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 229910052769 Ytterbium Inorganic materials 0.000 claims description 4
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 4
- CKMXBZGNNVIXHC-UHFFFAOYSA-L ammonium magnesium phosphate hexahydrate Chemical group [NH4+].O.O.O.O.O.O.[Mg+2].[O-]P([O-])([O-])=O CKMXBZGNNVIXHC-UHFFFAOYSA-L 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 4
- 150000002484 inorganic compounds Chemical class 0.000 claims description 4
- 229910052750 molybdenum Inorganic materials 0.000 claims description 4
- 239000011733 molybdenum Substances 0.000 claims description 4
- 229910052758 niobium Inorganic materials 0.000 claims description 4
- 239000010955 niobium Substances 0.000 claims description 4
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 4
- 150000002902 organometallic compounds Chemical class 0.000 claims description 4
- 229910052763 palladium Inorganic materials 0.000 claims description 4
- 229910052703 rhodium Inorganic materials 0.000 claims description 4
- 239000010948 rhodium Substances 0.000 claims description 4
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 4
- 229910052707 ruthenium Inorganic materials 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 229910052715 tantalum Inorganic materials 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052721 tungsten Inorganic materials 0.000 claims description 4
- 239000010937 tungsten Substances 0.000 claims description 4
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052727 yttrium Inorganic materials 0.000 claims description 4
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims description 4
- 229910052726 zirconium Inorganic materials 0.000 claims description 4
- 229910052684 Cerium Inorganic materials 0.000 claims description 3
- 150000003863 ammonium salts Chemical class 0.000 claims description 3
- SGUXGJPBTNFBAD-UHFFFAOYSA-L barium iodide Chemical compound [I-].[I-].[Ba+2] SGUXGJPBTNFBAD-UHFFFAOYSA-L 0.000 claims description 3
- 229940075444 barium iodide Drugs 0.000 claims description 3
- 229910001638 barium iodide Inorganic materials 0.000 claims description 3
- 229910021523 barium zirconate Inorganic materials 0.000 claims description 3
- DQBAOWPVHRWLJC-UHFFFAOYSA-N barium(2+);dioxido(oxo)zirconium Chemical compound [Ba+2].[O-][Zr]([O-])=O DQBAOWPVHRWLJC-UHFFFAOYSA-N 0.000 claims description 3
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 claims description 3
- 235000013980 iron oxide Nutrition 0.000 claims description 3
- WBJZTOZJJYAKHQ-UHFFFAOYSA-K iron(3+) phosphate Chemical class [Fe+3].[O-]P([O-])([O-])=O WBJZTOZJJYAKHQ-UHFFFAOYSA-K 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 235000005985 organic acids Nutrition 0.000 claims description 3
- 159000000008 strontium salts Chemical class 0.000 claims description 3
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- LVBNNUIJZCHSRM-UHFFFAOYSA-N [Ba].[Mn].[Ba] Chemical compound [Ba].[Mn].[Ba] LVBNNUIJZCHSRM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 235000014413 iron hydroxide Nutrition 0.000 claims description 2
- 229910000398 iron phosphate Inorganic materials 0.000 claims description 2
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 claims description 2
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical class [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 2
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 claims description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 239000004254 Ammonium phosphate Substances 0.000 claims 1
- RLETYRAOWLUDMD-UHFFFAOYSA-N [Mn].[Fe].[Ba] Chemical compound [Mn].[Fe].[Ba] RLETYRAOWLUDMD-UHFFFAOYSA-N 0.000 claims 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims 1
- 235000019289 ammonium phosphates Nutrition 0.000 claims 1
- 239000010428 baryte Substances 0.000 claims 1
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- 229940088623 biologically active substance Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
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- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 6
- 235000011837 pasties Nutrition 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 description 9
- -1 phosphate compound Chemical class 0.000 description 7
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- 238000001356 surgical procedure Methods 0.000 description 7
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
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- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
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- 229960001025 iohexol Drugs 0.000 description 1
- 229940029407 ioxaglate Drugs 0.000 description 1
- TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 description 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical group [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Chemical group O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
- 229910052746 lanthanum Inorganic materials 0.000 description 1
- FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 description 1
- JLRJWBUSTKIQQH-UHFFFAOYSA-K lanthanum(3+);triacetate Chemical compound [La+3].CC([O-])=O.CC([O-])=O.CC([O-])=O JLRJWBUSTKIQQH-UHFFFAOYSA-K 0.000 description 1
- FYDKNKUEBJQCCN-UHFFFAOYSA-N lanthanum(3+);trinitrate Chemical compound [La+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O FYDKNKUEBJQCCN-UHFFFAOYSA-N 0.000 description 1
- VQEHIYWBGOJJDM-UHFFFAOYSA-H lanthanum(3+);trisulfate Chemical compound [La+3].[La+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O VQEHIYWBGOJJDM-UHFFFAOYSA-H 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 229910001463 metal phosphate Inorganic materials 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- OKJMLYFJRFYBPS-UHFFFAOYSA-J tetraazanium;cerium(4+);tetrasulfate Chemical compound [NH4+].[NH4+].[NH4+].[NH4+].[Ce+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O OKJMLYFJRFYBPS-UHFFFAOYSA-J 0.000 description 1
- TYIZUJNEZNBXRS-UHFFFAOYSA-K trifluorogadolinium Chemical compound F[Gd](F)F TYIZUJNEZNBXRS-UHFFFAOYSA-K 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20218668U DE20218668U1 (de) | 2002-12-03 | 2002-12-03 | Rezepturen für Zementzubereitungen als Knochenersatz |
| DE20218668.7 | 2002-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050084094A true KR20050084094A (ko) | 2005-08-26 |
Family
ID=7977548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057009928A Ceased KR20050084094A (ko) | 2002-12-03 | 2003-12-03 | 골 대용품으로서의 시멘트 제제를 위한 조성물 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1560609A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2006524058A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050084094A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100540068C (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003302607A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE20218668U1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004050131A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101357673B1 (ko) * | 2012-09-03 | 2014-02-04 | 한국기계연구원 | 인산 마그네슘을 포함하는 경조직 재생용 지지체 조성물, 이를 포함하는 경조직 재생용 지지체 및 이들의 제조방법 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
| US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
| DE20218668U1 (de) * | 2002-12-03 | 2003-03-06 | Sanatis GmbH, 61191 Rosbach | Rezepturen für Zementzubereitungen als Knochenersatz |
| DE10340800A1 (de) * | 2002-12-20 | 2004-07-01 | Merck Patent Gmbh | Funktionalisierung unreaktiver Substrate |
| US7306786B2 (en) * | 2003-07-28 | 2007-12-11 | Skeletal Kinetics, Llc | Calcium phosphate cements comprising a water-soluble contrast agent |
| ES2396133T3 (es) | 2004-04-27 | 2013-02-19 | Kyphon SÀRl | Composiciones de sustitución osea y método de uso |
| US20050257714A1 (en) * | 2004-05-20 | 2005-11-24 | Constantz Brent R | Orthopedic cements comprising a barium apatite contrast agent |
| US7651701B2 (en) | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
| US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
| GB2442000A (en) * | 2006-06-07 | 2008-03-26 | Apatech Ltd | Biomedical materials containing gadolinium |
| US7507286B2 (en) | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
| WO2008023462A1 (en) * | 2006-08-21 | 2008-02-28 | Next21 K.K. | Bone model, bone filler and process for producing bone filler |
| DE102007052116B4 (de) * | 2007-10-22 | 2013-02-21 | Heraeus Medical Gmbh | Einkomponenten-Knochenzementpasten, deren Verwendung und Verfahren zu deren Aushärtung |
| DE102008010210A1 (de) * | 2008-02-20 | 2009-08-27 | Innotere Gmbh | Zubereitung für Magnesiumammoniumphosphat-Zemente |
| US9314545B2 (en) * | 2008-04-15 | 2016-04-19 | Life Science Enterprises, Inc. | Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement |
| US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
| US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
| CA2901528C (en) | 2013-02-20 | 2022-07-26 | Bone Support Ab | Heat-treated, sintered and micronized hydroxyapatite powder for use in a hardenable bone substitute composition |
| WO2016137013A1 (ja) * | 2015-02-26 | 2016-09-01 | 国立大学法人北海道大学 | 放射線治療用の病変識別マーカーおよび放射線治療用の病変識別マーカーキット |
| US20190201557A1 (en) * | 2016-08-25 | 2019-07-04 | National University Corporation Hokkaido University | Lesion identification marker utilizing bone cement for use in radiation therapy, and lesion identification marker kit for use in radiation therapy |
| RU2643337C1 (ru) * | 2017-06-06 | 2018-01-31 | Федеральное государственное бюджетное учреждение науки Институт химии Дальневосточного отделения Российской академии наук (ИХ ДВО РАН) | Резорбируемый рентгеноконтрастный кальций-фосфатный цемент для костной пластики |
| AU2021309336A1 (en) * | 2020-07-17 | 2023-02-16 | Zetagen Therapeutics, Inc. | Methods and compositions to graft bone using iron excipients |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03174349A (ja) * | 1989-12-01 | 1991-07-29 | Mitsubishi Materials Corp | 水硬性リン酸カルシウムセメント |
| JPH04329961A (ja) * | 1991-05-01 | 1992-11-18 | Onoda Cement Co Ltd | 医科用または歯科用硬化性組成物 |
| EP0511868B1 (en) * | 1991-05-01 | 1996-09-25 | Chichibu Onoda Cement Corporation | Medical or dental hardening compositions |
| JP3000718B2 (ja) * | 1991-05-28 | 2000-01-17 | 三菱マテリアル株式会社 | 薬物徐放性リン酸カルシウムセメント |
| DE69205736T2 (de) * | 1991-06-26 | 1996-06-13 | Nitta Gelatin Kk | Härtbares kalziumphosphathaltiges Material zum Reparieren von lebenden Hartgeweben. |
| JPH0734816B2 (ja) * | 1991-06-26 | 1995-04-19 | 新田ゼラチン株式会社 | 医科用および歯科用硬化性材料 |
| JPH078548A (ja) * | 1993-06-24 | 1995-01-13 | Mitsui Toatsu Chem Inc | 硬化性生体用粉材 |
| JPH078550A (ja) * | 1993-06-28 | 1995-01-13 | Mitsuo Kondo | 医療用リン酸カルシウム |
| US6075067A (en) * | 1994-08-15 | 2000-06-13 | Corpipharm Gmbh & Co | Cement for medical use, method for producing the cement, and use of the cement |
| US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
| JP4215884B2 (ja) * | 1998-03-23 | 2009-01-28 | 日本特殊陶業株式会社 | リン酸カルシウムセメント及びリン酸カルシウムセメント組成物 |
| US6593394B1 (en) * | 2000-01-03 | 2003-07-15 | Prosperous Kingdom Limited | Bioactive and osteoporotic bone cement |
| JP2001218774A (ja) * | 2000-02-10 | 2001-08-14 | Ngk Spark Plug Co Ltd | リン酸カルシウム系セメント用混練器具及びそれを用いたリン酸カルシウム系セメントの調製方法 |
| DE10032220A1 (de) * | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
| JP2004511320A (ja) * | 2000-10-16 | 2004-04-15 | ユニバーシテイ・オブ・サウス・カロライナ | 反応性リン酸カルシウムナノ粒子を含む生体適合性セメント並びに前記セメントの製造及び使用方法 |
| DE20218668U1 (de) * | 2002-12-03 | 2003-03-06 | Sanatis GmbH, 61191 Rosbach | Rezepturen für Zementzubereitungen als Knochenersatz |
-
2002
- 2002-12-03 DE DE20218668U patent/DE20218668U1/de not_active Expired - Lifetime
-
2003
- 2003-12-03 AU AU2003302607A patent/AU2003302607A1/en not_active Abandoned
- 2003-12-03 JP JP2004557582A patent/JP2006524058A/ja active Pending
- 2003-12-03 KR KR1020057009928A patent/KR20050084094A/ko not_active Ceased
- 2003-12-03 WO PCT/US2003/038580 patent/WO2004050131A1/en not_active Ceased
- 2003-12-03 CN CNB2003801049195A patent/CN100540068C/zh not_active Expired - Fee Related
- 2003-12-03 EP EP03808436A patent/EP1560609A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101357673B1 (ko) * | 2012-09-03 | 2014-02-04 | 한국기계연구원 | 인산 마그네슘을 포함하는 경조직 재생용 지지체 조성물, 이를 포함하는 경조직 재생용 지지체 및 이들의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004050131A1 (en) | 2004-06-17 |
| AU2003302607A1 (en) | 2004-06-23 |
| CN1849145A (zh) | 2006-10-18 |
| HK1097778A1 (zh) | 2007-07-06 |
| CN100540068C (zh) | 2009-09-16 |
| EP1560609A1 (en) | 2005-08-10 |
| DE20218668U1 (de) | 2003-03-06 |
| JP2006524058A (ja) | 2006-10-26 |
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