KR20050044491A - 가용화된 토포이소머라제 독 - Google Patents

가용화된 토포이소머라제 독 Download PDF

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Publication number
KR20050044491A
KR20050044491A KR1020047007448A KR20047007448A KR20050044491A KR 20050044491 A KR20050044491 A KR 20050044491A KR 1020047007448 A KR1020047007448 A KR 1020047007448A KR 20047007448 A KR20047007448 A KR 20047007448A KR 20050044491 A KR20050044491 A KR 20050044491A
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KR
South Korea
Prior art keywords
compound
substituted
alkyl
formula
mmol
Prior art date
Application number
KR1020047007448A
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English (en)
Korean (ko)
Inventor
에드문드 제이. 라보이
알렉산더 엘. 러셀만
레로이 에프. 리우
Original Assignee
루트거스, 더 스테이트 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 루트거스, 더 스테이트 유니버시티 filed Critical 루트거스, 더 스테이트 유니버시티
Publication of KR20050044491A publication Critical patent/KR20050044491A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
KR1020047007448A 2001-11-14 2002-11-14 가용화된 토포이소머라제 독 KR20050044491A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33273401P 2001-11-14 2001-11-14
US60/332,734 2001-11-14

Publications (1)

Publication Number Publication Date
KR20050044491A true KR20050044491A (ko) 2005-05-12

Family

ID=23299632

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047007448A KR20050044491A (ko) 2001-11-14 2002-11-14 가용화된 토포이소머라제 독

Country Status (15)

Country Link
US (4) US7049315B2 (US07049315-20060523-C00024.png)
EP (3) EP1465625B1 (US07049315-20060523-C00024.png)
JP (3) JP4628675B2 (US07049315-20060523-C00024.png)
KR (1) KR20050044491A (US07049315-20060523-C00024.png)
AT (1) ATE456952T1 (US07049315-20060523-C00024.png)
AU (1) AU2002363658B2 (US07049315-20060523-C00024.png)
CA (1) CA2467774C (US07049315-20060523-C00024.png)
CY (1) CY1110631T1 (US07049315-20060523-C00024.png)
DE (1) DE60235287D1 (US07049315-20060523-C00024.png)
DK (1) DK1465625T3 (US07049315-20060523-C00024.png)
ES (1) ES2340473T3 (US07049315-20060523-C00024.png)
MX (1) MXPA04004606A (US07049315-20060523-C00024.png)
PT (1) PT1465625E (US07049315-20060523-C00024.png)
SI (1) SI1465625T1 (US07049315-20060523-C00024.png)
WO (1) WO2003041660A2 (US07049315-20060523-C00024.png)

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AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
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ATE405568T1 (de) 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004014906A2 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003290818A1 (en) 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
EP1778228A4 (en) 2004-07-09 2010-08-11 Medisyn Technologies Inc THERAPEUTIC CONNECTION AND TREATMENTS
KR20090040265A (ko) * 2006-05-24 2009-04-23 닥터 레디스 레보러터리즈 리미티드 5(ｓ)-(2'-히드록시에톡시)-20(ｓ)-캄프토테신의 결정질 형태
US8394818B2 (en) 2008-10-17 2013-03-12 Dana-Farber Cancer Institute, Inc. Soluble mTOR complexes and modulators thereof
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WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2010127360A1 (en) * 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
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WO2012015875A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating hematological malignancies
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
CN111925370B (zh) * 2020-09-01 2023-07-21 湖北科苑生物药业有限公司 一种吡嗪并吡唑并萘啶类化合物及其制备方法与应用

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Also Published As

Publication number Publication date
US7781587B2 (en) 2010-08-24
PT1465625E (pt) 2010-03-09
SI1465625T1 (sl) 2010-06-30
WO2003041660A3 (en) 2003-10-16
WO2003041660A2 (en) 2003-05-22
ES2340473T3 (es) 2010-06-04
DK1465625T3 (da) 2010-05-31
JP2010184942A (ja) 2010-08-26
CY1110631T1 (el) 2015-04-29
EP1465625B1 (en) 2010-02-03
US20110136812A1 (en) 2011-06-09
AU2002363658B2 (en) 2008-09-11
CA2467774C (en) 2011-09-20
US20060052381A1 (en) 2006-03-09
JP2005511617A (ja) 2005-04-28
EP2286812A1 (en) 2011-02-23
JP2013166801A (ja) 2013-08-29
US7049315B2 (en) 2006-05-23
MXPA04004606A (es) 2004-09-10
US8389721B2 (en) 2013-03-05
JP5337104B2 (ja) 2013-11-06
ATE456952T1 (de) 2010-02-15
CA2467774A1 (en) 2003-05-22
US20050009824A1 (en) 2005-01-13
JP4628675B2 (ja) 2011-02-09
US20090239871A1 (en) 2009-09-24
EP1465625A4 (en) 2005-06-08
US7517883B2 (en) 2009-04-14
DE60235287D1 (de) 2010-03-25
EP2196205A1 (en) 2010-06-16
EP1465625A2 (en) 2004-10-13

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