KR20050028544A - Anti-wrinkle cosmetic composition and its manufacturing method containing a pure retinol stabilized with a nano size of multiple liquid crystal membrane capsule - Google Patents

Abstract

An anti-wrinkle cosmetic composition comprising pure retinol stabilized with nano sized multiple liquid crystal membrane capsules and a manufacturing method thereof are provided, which composition stabilizes retinol that is unstable to photo, heat and air with capsules, maintains pure retinol content for a long period, and rapidly delivering the nano sized multiple liquid crystal membrane capsules containing the pure retinol into the inner side of the skin. The anti-wrinkle cosmetic composition comprising pure retinol stabilized with nano sized multiple liquid crystal membrane capsules comprises an oil phase portion comprising 0.9 to 9 wt.% of liquid crystal membrane forming agent including 0.3 to 3 wt.% of polyoxyethylenestearate, 0.1 to 2 wt.% of dipolyhydroxyethylenestearate and 0.5 to 4 wt.% of hydrogenated lecitin, 3 to 10 wt.% of surfactant, and 11.3 to 34 wt.% of oily base including 10 to 25 wt.% of ester oil, 0.5 to 3 wt.% of C12-C16 alkane, 0.3 to 3 wt.% of C14-C20 alcohol and 0.5 to 3 wt.% of C12-C20 fatty acid; a gelating portion comprising 2 to 12 wt.% of glycerin and 1 to 5 wt.% of purified water; a wrinkle inhibiting portion comprising 0.01 to 3 wt.% of pure retinol and 0.1 to 1 wt.% of antioxidant; and a water phase portion comprising 7 to 20 wt.% of hydrating agent, 1 to 6 wt.% of thickening agent, 2 to 20 wt.% of additives and 35 to 60 wt.% of purified water.

Description

Anti-wrinkle cosmetic composition and its manufacturing method containing a pure retinol stabilized with a nano size of multiple liquid crystal membrane capsule}

The present invention relates to a cosmetic composition for preventing wrinkles comprising pure retinol encapsulated in a nano-sized multi-liquid crystal film and a method for preparing the same, and more particularly, pure retinol in a lamellar multi-liquid crystal gel paste consisting of an oil phase part and a gelling agent part. To encapsulate and encapsulate the mixture with the aqueous phase and then primary emulsification to obtain a pure liquid retinol encapsulated spherical multi-liquid crystal membrane capsule, which was added to a line type ultrafast particle pulverizer and emulsified secondly By making the nano-liquid crystal capsules of the nano-sized capsules, nano-sized capsules smaller than the lipid gap of the skin effectively penetrate the skin effectively and increase the anti-wrinkle effect by pure retinol, and external environment such as light, heat, and air Pure retinol, which is fragile, can be included in cosmetics in a stable way It relates to a cosmetic composition for preventing wrinkles and a method of manufacturing including the pure retinol encapsulated into multiple liquid crystal films of nanoscale expressing the effect of causing.

In general, the W / O form of the formulation is an inner phase of the water phase and the continuous phase surrounding the oil stabilizes the active ingredient of the water phase, and since the continuous phase is an oil, it prevents deformation due to external environmental stimuli such as water and sebum. At the same time, there is an advantage that can maintain the moisturizing and makeup persistence for a long time. However, useful active ingredients such as retinol are difficult to stabilize and have a disadvantage such as stickiness due to a lot of oily feeling in usability, and thus did not meet the demands of ordinary consumers.

In order to improve the feeling of use, water-silicone (W / S) formulations have been developed by replacing silicones in continuous phase with silicones and using silicone surfactants. It overcomes the problem of usability which is a disadvantage of W / O emulsion. However, such formulations are also difficult to stabilize the useful active ingredients, such as retinol, the price of silicone oil than the general oil has a disadvantage that the overall product is expensive, burdening consumers.

On the other hand, the gel emulsion (oil emulsion) of the oil in water (O / W) formulation (gel emulsion) is excellent in the usability and moisturizing properties, the product stability is also superior to the general W / O type emulsion. However, it is difficult to stabilize the water-soluble active ingredient due to exposure to the external environment, and it is difficult to stabilize oil-soluble pure retinol having a very high activity.

In addition, the particle size of the emulsion constituting the cosmetic prepared by the conventional method is much larger than the skin lipid gap was not effective for penetration into the skin.

Accordingly, the present inventors have made diligent efforts to solve the above problems, and as a result of stably including a highly active oil-soluble pure retinol in cosmetics and increasing the penetration into the skin, a multi-liquid crystal membrane containing pure retinol A method of nanosizing the capsules was considered.

In other words, it has excellent skin affinity, so that it is possible to construct a drug delivery system that delivers to the desired site more stably as well as the sustained use effect by incorporating and stabilizing pure retinol in a very mild multi-liquid crystal layer without any skin irritation. It became.

In addition, if the capsule containing pure retinol encapsulated and stabilized in the multi-liquid crystal membrane as described above is smaller in size than the lipid gap of the skin, they can more effectively penetrate the skin more effectively and further increase the anti-wrinkle effect by pure retinol. The present invention has been completed.

Therefore, the present invention realizes the stabilization of pure retinol with a severe change over time due to external stimulation such as light, temperature change, oxidation, etc., and includes pure retinol encapsulated in a nano-sized multi-liquid crystal membrane to facilitate penetration into the skin. Its purpose is to provide a cosmetic composition for preventing wrinkles and a method of manufacturing the same.

The present invention is a liquid crystal film forming agent consisting of 0.3 to 3% by weight of polyoxyethylene stearate, 0.1 to 2% by weight of dipolyhydroxyethylene stearate, and 0.5 to 4% by weight of hydrogenetidrecithin, and 3 to 10% by weight of surfactant %, 10-25 wt% of ester oil, 0.5-3 wt% of higher alkanes having 12 to 16 carbon atoms, 0.3-3 wt% of higher alcohols having 14 to 20 carbon atoms, and 0.5 to 3 wt% of higher fatty acids having 14 to 20 carbon atoms Oil phase part containing the oily base which consists of%; A gelling agent containing 2 to 12% by weight of glycerin and 1 to 5% by weight of purified water; Anti-wrinkle ingredients containing 0.01 to 3% by weight of pure retinol and 0.1 to 1% by weight of antioxidant; And a retinol encapsulated in a nano-sized multi-liquid crystal film composed of an aqueous phase containing 7 to 20 wt% of a moisturizer, 1 to 6 wt% of a thickener, 2 to 20 wt% of an additive, and 35 to 60 wt% of purified water. It is characterized by a cosmetic composition.

In the present invention, an oil phase portion prepared by mixing a liquid crystal film forming agent, a surfactant, and an oily base to be heated to 80 to 85 ° C., and a gelling agent portion prepared by heating a glycerin aqueous solution to 80 to 85 ° C. are maintained at 80 to 85 ° C. While stirring at 2,500 to 3,500 rpm to form a lamellar multi-liquid crystal gel, and then quenching it to a temperature of 35 to 45 ° C. to obtain a lamellar multi-liquid crystal gel paste; Encapsulating the anti-wrinkle component in the multi-liquid crystal film gel paste and encapsulating the anti-wrinkle component by stirring at 35 to 45 ° C. at 2,500 to 3,500 rpm; To the encapsulated anti-wrinkle component, a moisturizer, a thickener, an additive, and purified water were added at 45-55 ° C. to homogenize an aqueous phase, and then emulsified at 35-45 ° C. at a rate of 2,500 to 3,500 rpm to prevent wrinkles. Obtaining a spherical multiliquid crystal capsule in which the components are encapsulated; And cooling the spherical multi-liquid crystal film capsule to 30 to 35 ° C., and then putting the spherical multi-liquid crystal film capsule into a line type ultra-high speed particle pulverizer and performing secondary emulsification at a speed of 10,000 to 15,000 rpm to obtain a nano-sized multi-crystal film capsule. It includes a method for producing a cosmetic composition for preventing wrinkles comprising a retinol encapsulated in a nano-sized multi-liquid crystal film made of a.

Referring to the present invention in more detail as follows.

The present invention relates to a cosmetic composition for preventing wrinkles and a method for preparing the same for stably incorporating pure retinol in a cosmetic composition with a strong change over time such as light, heat, air, and the like to easily penetrate the skin.

First, the composition components constituting the cosmetic composition for preventing wrinkles of the present invention will be described in detail.

The anti-wrinkle cosmetic composition of the present invention consists of an oil phase part, a gelling agent part, an anti-wrinkle ingredient part and an aqueous phase part, and the components forming each part are as follows.

Firstly, it is an oil phase part, which contains 0.9 to 9% by weight of the liquid crystal film forming agent, 3 to 10% by weight of the surfactant, and 11.3 to 34% by weight of the oily base.

The liquid crystal film-forming agent functions to form a film containing the anti-wrinkle component stably, and may be polyoxyethylene stearate, dipolyhydroxyethylene stearate, hydrogenetidrecitin, and the like. It is to use a mixture consisting of 0.3 to 3% by weight of polyoxyethylene stearate, 0.1 to 2% by weight of dipolyhydroxyethylene stearate, and 0.5 to 4% by weight of hydrogenetirecithin.

Among the components constituting the oil phase, the surfactant promotes the formation of the lamellar multi-liquid crystal gel paste by the liquid crystal film-forming agent and stabilizes the multi-liquid crystal membrane capsule. Particularly, the oil-based components are easily mixed with the aqueous components. As the surfactant, it is preferable to use a nonionic surfactant such as polystearic acid monooxyethylene sorbitan.

The oily base may be an ester oil, higher alkanes having 12 to 16 carbon atoms, higher alcohols having 14 to 20 carbon atoms, higher fatty acids having 14 to 20 carbon atoms, and preferably 10 to 25% by weight of ester oil. It contains 0.5 to 3% by weight of higher alkanes such as hexa-decane, 0.3 to 3% by weight of high alcohol and 0.5 to 3% by weight of higher fatty acid, and the content range of each component of the oily base is a user's feeling test. As an experimentally found content in, when less than the amount is included in the oil content is too small may weaken the soft feeling when used, on the contrary, if it contains more than the amount may have a problem that feel too oily . Specific examples of the component that can be used as the oily base include those selected from tri (caprylic capric acid) glycerin, octyldodecyl myristate, cetyloctanoate and isostearyl isostearate as ester oils. The higher alcohol may be selected from cetanol, stearyl alcohol, behenyl alcohol and the like, and the higher fatty acid may be selected from stearic acid, oleic acid, lauric acid and palmitic acid.

Secondly, it is a gelling unit, and contains 2 to 12% by weight of glycerin and 1 to 5% by weight of purified water.

Thirdly, the anti-wrinkle ingredient part contains 0.01 to 3% by weight of pure retinol and 0.1 to 1% by weight of antioxidant. The pure retinol is the main component used to give an anti-wrinkle effect, and the antioxidant is used to help inhibit the oxidation of the pure retinol, using a component that can be easily mixed with pure retinol, for example Natural tocopherol and the like can be used.

The last part which comprises the antiwrinkle cosmetic composition of this invention is a water phase part, and contains 7 to 20 weight% of moisturizers, 1 to 6 weight% of thickeners, 2 to 20 weight% of additives, and 35 to 60 weight% of purified water.

The moisturizing agent is a component used for the purpose of improving skin moisturizing, and specifically, for example, 1,3-butylene glycol, concentrated glycerin, polyethylene glycol, sodium hyaluronate and the like can be used. The thickener is a component that helps to emulsify the oil phase or adjust the viscosity of the cosmetic after emulsification. Specifically, the thickener is selected from conventional polyglyceryl methacrylate, carboxyvinyl polymer and hydroxyethyl cellulose. Can be used. The additives may be selected and used according to the needs of those skilled in the art, alcohol, fragrances, preservatives and pigments commonly used in cosmetic compositions.

Referring to the method for producing a cosmetic composition for preventing wrinkles of the present invention consisting of the above components in more detail in each step as follows.

First, as a step of obtaining a lamellar multi-liquid crystal film gel paste, a liquid crystal film forming agent, a surfactant, and an oily base are mixed and heated to 80 to 85 ° C. to prepare an oil phase part. Separately, prepare a gelling agent by heating a glycerin aqueous solution prepared by uniformly mixing glycerin and purified water to 80 to 85 ° C, and then putting the oily part and the gelling agent into a vacuum emulsion tank capable of temperature control and stirring to maintain the temperature at 80 to 85 ° C. While stirring at 2,500 to 3,500 rpm to form a lamellar multi-liquid crystal gel. The lamellar multi-liquid crystal gel is quenched to a temperature of 35 to 45 ° C. to obtain a lamellar multi-liquid crystal gel paste, which is a step in which the oil phase forming the multi-liquid crystal film is substantially homogenized. Do. That is, the liquid crystal film may not be properly formed when the temperature applied during emulsification is maintained below 80 ° C., and when the stirring speed is maintained below 2,500 rpm, there may be a problem in that the particle form of the liquid crystal film to be formed is uneven. In addition, when it exceeds 3,500 rpm, the size of the liquid crystal film to be formed is too small, the problem that the encapsulation of the next added anti-wrinkle component does not occur properly occurs. In this step, the components and contents of the oil phase portion and the gelling portion are the same as the components and contents used in the cosmetic composition for preventing wrinkles.

Secondly, the anti-wrinkle ingredient is encapsulated in the above-mentioned multi-liquid crystal film gel paste, and the anti-wrinkle ingredient is added to the multi-liquid crystal film gel paste prepared in the above step, and then maintained at 35-45 ° C. with a homomixer. Stir at 3,500 rpm to encapsulate the anti-wrinkle ingredients. At this time, if the encapsulation temperature is less than 35 ℃ anti-wrinkle ingredient penetrates into the multi-liquid crystal film gel paste is not encapsulated, if it exceeds 45 ℃ there is a fear that the anti-wrinkle component is modified. The anti-wrinkle ingredients are the same as the ingredients and contents described in the composition.

Thirdly, as a first emulsifying step for preparing a spherical multi-liquid crystal capsule, first, a moisturizer, a thickener, an additive, and purified water are added to a water melting tank, and stirred at 400 to 600 rpm with a paddle mixer while maintaining 45 to 55 ° C. After homogenizing the water phase in advance, and then put into the vacuum emulsion tank containing the encapsulated anti-wrinkle component is a step of first emulsifying at 2,500 ~ 3,500 rpm with a homomixer while maintaining 35 ~ 45 ℃. The spherical multi-liquid crystal film capsule formed under the above emulsification conditions has a size of 1 to 3 μm. As described above, in order to transform the lamellar multi-liquid crystal film gel paste into a spherical multi-liquid crystal film capsule through primary emulsification, the rotation speed of the homomixer is important. If the rotation speed is out of the range, particles of the liquid crystal film are formed. The shape is not uniform in spherical shape.

Finally, the second step of the emulsification of the spherical anti-wrinkle ingredient encapsulated spherical multi-liquid crystal film capsules prepared in the above step is nanosized. That is, the spherical multi-liquid crystal membrane capsule is cooled to 30 to 35 ° C and then put into a line type ultrafast particle pulverizer for secondary emulsification at a speed of 10,000 to 15,000 rpm to nanosize. At this time, if the temperature applied during the secondary emulsification is out of the range, there is a problem that the capsules are united again while the size of the capsule is smaller, and also, the stirring speed and the number of stirring times are also important factors for preparing the composition of nano size. If the stirring speed is less than 10,000 rpm, the particles cannot be split into small nanoparticles, and if the stirring speed exceeds 15,000 rpm, the particles cannot be made into nano-size by coalescing the particles by too strong a force. If more than two times, the nano-sized particles are coalesced to obtain a nano-sized multi-liquid crystal capsule.

On the other hand, the line-type ultra-fast particle pulverizer applied during the second emulsification was used by the inventors. The above-mentioned ultra-high-speed particle pulverizer has a structure in which an ultra homo mixer is connected in three stages inside a hollow line such as a pipe, and the grinding force is about 6 times that of a conventional homo mixer and about 4 times that of an ultra homo mixer. As a special device that exerts the above-mentioned power, the stirring speed that can be output is in the range of 1,000 to 20,000 rpm, but the number of grinds and the force to grind are several times as powerful even when operated at the same value of rpm as the conventional mixer.

The cosmetic composition for preventing wrinkles of the present invention can suppress the glass of pure retinol, which is an anti-wrinkle ingredient, in the inner phase by the lamellar multi-liquid crystal film structure according to the above-described manufacturing method, and the existing oil phase / water phase ( oil in water, O / W) It has a high lasting effect of anti-wrinkle ingredients compared to the emulsified form, and is composed of a very small nano-sized multi-liquid crystal capsule encapsulated with anti-wrinkle ingredients. The structure is very similar to the skin lipid membrane (cell membrane) and has excellent skin affinity to reduce skin irritation caused by chemical stress.

Although the present invention will be described in more detail with reference to Examples, the present invention is not limited by the following Examples.

Examples 1-3 and Comparative Examples 1-3

To prepare a multi-liquid crystal film capsule composition for cosmetics according to the composition shown in Table 1, the preparation method is as follows.

First, the oil phase was placed in a vacuum emulsion tank capable of temperature control and stirring, and heated to a temperature of 80 to 85 ° C., and the gelling agent was added to an oil phase melting tank capable of heating and stirring, and then heated to a temperature of 80 to 85 ° C. . The gelling agent was added to the vacuum emulsion tank containing the oil phase, and the temperature was maintained at 80 to 85 ° C. while stirring at a speed of 2,500 to 3,500 rpm for 10 minutes with a homomixer to form a lamellar multi-liquid crystal gel. Lamellar-type multi-liquid crystal gel paste was prepared by quenching to ˜45 ° C., and the appearance of the lamellar multi-liquid crystal gel paste was observed under a microscope (optical microscope, Olympus BX40, 400 times magnification), and the results were attached. Figure is shown in FIG. As shown in FIG. 1, it was found that the liquid crystal film was easily formed due to the unique light scattering phenomenon when observed through an optical microscope.

The anti-wrinkle ingredients were added to the lamellar gel paste formed in the vacuum emulsification tank and stirred at a speed of 2,500 to 3,500 rpm with a homomixer while maintaining the temperature at 35 to 45 ° C. Retinol was encapsulated. Separately, the water phase part was put into the water melting tank, and stirred at a speed of 400 to 600 rpm with a paddle mixer while maintaining the temperature at 45 to 55 ° C to homogenize. The homogenized water phase part was introduced into a vacuum emulsion tank, and the emulsion was firstly emulsified at a speed of 2,500 to 3,500 rpm with a homomixer while maintaining the temperature at 35 to 45 ° C. A multi-liquid crystal membrane capsule was prepared, and the spherical multi-liquid crystal capsule of Example 1 was observed by observing with a micrograph (optical microscope, Olympus BX40, 400 times magnification), and the results are shown in the accompanying drawings.

The formed 1-3 μm-sized spherical liquid crystal membrane capsule was cooled to 30 to 35 ° C., and introduced into a linear ultra-fast particle pulverizer and subjected to nanosized multi-liquid crystal membrane capsule through secondary emulsification to be treated at 12,000 to 13,000 rpm. An anti-wrinkle cosmetic composition containing pure retinol stabilized by was prepared, and a nano-sized multi-liquid crystal capsule (Example 1) containing pure retinol prepared in the above process was micrograph (optical microscope, Olympus BX40, 400). The magnification was observed to confirm that the composition was nanoscaled, and the results are shown in the accompanying drawings of FIG. 3.

Separately, the particle size distribution was examined by a particle size distribution analyzer [Photal OTSUKA ELECTRONICS, JAPAN (ELS-800)], and the average particle size is shown in Table 1 below.

In the case of Examples 2 to 3, as in Example 1, the formation of the multi-liquid crystal gel paste shown in FIG. 1 and the formation of the spherical multi-liquid crystal membrane capsules having a size of 1 to 3 μm shown in FIG. The particle size distribution was examined by a particle size distribution analyzer, and the average particle size was found to be formed in the nano size of 36 nm (Example 1), 124 nm (Example 2) and 80 nm (Example 3).

When the content of the liquid crystal film-forming agent is less than 0.9% by weight as in Comparative Example 1, or the content of the liquid crystal film-forming agent is more than 9.0% by weight as in Comparative Example 3, the liquid crystal film itself is not well formed, and Comparative Example 2 and As described above, when the amount of the nonionic surfactant in the oil phase portion was less than 3% by weight, liquid crystal formation was unstable, and when the secondary emulsion was put into a line type ultrafast particle pulverizer, the particles were united to form a multi-liquid crystal membrane capsule of 5 μm or more.

Test Example

1) stability

The cosmetic compositions prepared in the compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were visually separated from each other at a temperature of 50 ° C., 40 ° C., 25 ° C., and 5 ° C., or odor and change in appearance. Observation and evaluation were made. At this time, the observation was observed for 1 month at 50 ℃, 3 months at 40 ℃ and 5 ℃, respectively, for 12 months at 25 ℃ and the results are shown in Table 2 below.

2) Pure Retinol Content Test

Each of the cosmetic compositions prepared in the compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were placed in a sealed aluminum tube container at a temperature of 15 to 25 ° C./relative humidity of 55 to 65% and remained after one year. The content of one pure retinol was measured. The instrument used was a thermo-hygrostat (VS-9111H-800, Vision Science Co., Ltd.) and a high-speed liquid chromatograph (HPLC LC-10AD, Shimatsu Japan). The results are shown in Table 2 below.

division Example Comparative example One 2 3 One 2 3 Stability ◎ ◎ ◎ × ○ △ Retinol content ○ ◎ ○ × △ ×  ◎; Very good stability, Retinol content over 95% ○; Excellent stability, maintaining retinol content of 80 to 95% △; Stability moderate (good), maintaining retinol content of 60 to 80% ×; Poor stability, less than 60% retinol content

As shown in Table 2, Examples 1 to 3 of the present invention showed excellent or very good results in both stability and retinol content tests, especially when 5.5 wt% of the liquid crystal film former was used (Example 2 ) Shows a very good result in maintaining the retinol content.

On the other hand, if the liquid crystal film forming agent is less than 0.9% by weight (Comparative Example 1) or 9.0% by weight or more (Comparative Example 3), the formation of the liquid crystal film is unstable and thus it is impossible to secure stability and maintain the content of retinol. If the amount is less than 3% by weight (Comparative Example 2), the stability is excellent, but the content of the retinol is not maintained, it can be seen that it is difficult to commercialize.

As described above, according to the anti-wrinkle cosmetic composition of the present invention, the multi-liquid crystal membrane of pure retinol, which is a typical anti-wrinkle component, was difficult to formulate because of its excellent efficacy but very unstable against various external environmental changes such as light, heat, and air. It could be effectively stabilized by the capsule, it was possible to obtain the effect of maintaining the content of pure retinol for a longer period of time.

Moreover, the nano-sized capsules effectively stabilized as described above can form a size smaller than the lipid gap of the skin, so that the penetration into the skin is faster, thereby providing an excellent anti-wrinkle effect that is differentiated from conventional anti-wrinkle cosmetics. You can expect

Figure 1 shows an optical micrograph (a) and schematic diagram (b) of a lamellar multi-liquid crystal gel paste containing pure retinol during the preparation of the anti-wrinkle cosmetic composition of the present invention.

Figure 2 shows the optical micrograph (a) and schematic diagram (b) of the spherical liquid crystal membrane capsule containing pure retinol during the manufacturing process of the cosmetic prepared according to the present invention.

Figure 3 shows an optical micrograph of the anti-wrinkle cosmetic composition comprising a pure retinol encapsulated in a nano-sized multi-liquid crystal film prepared according to the present invention.

Claims (9)

A liquid crystal film forming agent composed of 0.3 to 3% by weight of polyoxyethylene stearate, 0.1 to 2% by weight of dipolyhydroxyethylene stearate, and 0.5 to 4% by weight of hydrogenity lecithin, 3 to 10% by weight of a surfactant, 10 to 25% by weight of ester oil, 0.5 to 3% by weight of higher alkanes having 12 to 16 carbon atoms, 0.3 to 3% by weight of higher alcohols having 14 to 20 carbon atoms and 0.5 to 3% by weight of higher fatty acids having 14 to 20 carbon atoms An oil phase portion containing an oily base; A gelling agent containing 2 to 12% by weight of glycerin and 1 to 5% by weight of purified water; Anti-wrinkle ingredients containing 0.01 to 3% by weight of pure retinol and 0.1 to 1% by weight of antioxidant; And Water phase part containing 7 to 20% by weight of moisturizer, 1 to 6% by weight of thickener, 2 to 20% by weight of additive and 35 to 60% by weight of purified water Anti-wrinkle cosmetic composition comprising a retinol encapsulated in a nano-sized multi-liquid crystal film, characterized in that consisting of. The anti-wrinkle cosmetic composition according to claim 1, wherein the total content of the liquid crystal film forming agent is 0.9 to 9% by weight based on the total cosmetic composition. The anti-wrinkle cosmetic composition according to claim 1, wherein the surfactant is a nonionic surfactant. The anti-wrinkle cosmetic composition according to claim 1, wherein the total content of the oily base is 11.3 to 34 wt% in the total cosmetic composition. The anti-wrinkle cosmetic composition of claim 1, wherein the antioxidant is natural tocopherol. The anti-wrinkle cosmetic composition according to claim 1, wherein the moisturizing agent is one or more mixtures selected from 1,3-butylene glycol, concentrated glycerin, polyethylene glycol, and sodium hyaluronate. The anti-wrinkle cosmetic composition of claim 1, wherein the thickener is one or more mixtures selected from polyglyceryl methacrylate, carboxyvinyl polymer, and hydroxyethyl cellulose. The oil phase portion prepared by mixing the liquid crystal film forming agent, the surfactant, and the oily base at 80 to 85 ° C., and the gelling agent portion prepared by heating the glycerin aqueous solution to 80 to 85 ° C. are mixed and maintained at 2,500 to 3,500 ° C. stirring at rpm to form a lamellar multi-liquid crystal gel, and then quenching it to a temperature of 35 to 45 ° C. to obtain a lamellar multi-liquid crystal gel paste; Encapsulating the anti-wrinkle component comprising pure retinol and an antioxidant to the multi-liquid crystal film gel paste and stirring at 35 to 45 ° C. at 2,500 to 3,500 rpm; To the encapsulated anti-wrinkle component, a moisturizer, a thickener, an additive, and purified water were added at 45-55 ° C. to homogenize an aqueous phase, and then emulsified at 35-45 ° C. at a rate of 2,500 to 3,500 rpm to prevent wrinkles. Obtaining a spherical multiliquid crystal capsule in which the components are encapsulated; And After cooling the spherical multi-liquid crystal membrane capsule to 30 ~ 35 ℃ step into a line-type ultra-fast particle mill to obtain a nano-sized multi-liquid crystal membrane capsule by secondary emulsification at a speed of 10,000 ~ 15,000 rpm Method for producing a cosmetic composition for preventing wrinkles comprising a retinol encapsulated in a nano-sized multi-liquid crystal film, characterized in that made. The method of claim 8, wherein the spherical multi-liquid crystal film capsule has a size of 1 to 3 ㎛.