KR20040072559A - Production of nutritious health food composition for treatment of diabetic patients using silkworm, mulberry leaf, tortoise shell, tricalcium phosphate and sodium silicoaluminate - Google Patents

Abstract

PURPOSE: A method of making nutritious health food by mixing and grinding silkworm, mulberry leaf, shells of tortoise(Amyda sinensis), tricalcium phosphate and sodium silicoaluminate is provided. The product is useful as a therapeutic food composition for treatment of diabetic patients. CONSTITUTION: The nutritious food composition contains 20 to 30% by weight of silkworm, 20 to 30% by weight of a mulberry leaf, 30 to 48% by weight of shells of tortoise(Amyda sinensis) and tricalcium phosphate and 1 to 1.9% by weight of sodium silicoaluminate. During the manufacture of the composition, the raw material is heated at 30 to 40deg.C, ground and then formed into a granule or encapsulated.

Description

A method for producing a nutritional health food for diabetic patients using silkworms, mulberry leaves, growing spines, tricalcium phosphate and sodium silicoalminium phosphate. {Omitted}

In food and medicine, organic materials are being pursued as food. This is because the safety of organic matter in the blood was evaluated as high. However, it is a trend of conventional dietary medicine to pursue only organic matter, which is a trend of modern alternative medicine that trace minerals are becoming a high energy source in all cells and bodies.

Therefore, the present invention is to provide nutrition to diabetic patients as a preferred organic food and reduce the amount of food in order to reduce the damage caused by the excess of nutrition to give nutritional deficiency phenomenon and psychological pain and to suffer difficulties It relieves and increases the content of certified mineral materials to activate the function of cells, organs or the whole body, to satisfy nutrition, and in particular, to increase the ability of insulin transpiration and high protein hydrolysis to reduce the burden on the function of the liver and the liver It is a challenge of the present technology to make proper formulation transplantation convenient to make foods to help them.

(1) Silkworms containing 18 amino acids and 10 pubtides, mulberry leaves containing polysaccharides, pectin, and adeno acid, in the same weight ratio, contain 30-50% of all foods, and the main component of gyano spines and tertiary phosphate 48% to 48.5% of calcium, 1% to 1.9% of siligoammonium acid is mixed, and the same amount of organic and inorganic materials is mixed to 45% to 55%. Finishing the powder is finished in a granule or capsule, solidified and packaged to be fed with a beverage.

The manufacturing process will be described in detail by way of examples.

Example 1

The compounding weight ratio for producing 1 kg of the present invention is completed by the following process.

A. Experimental Example 1

1. Experimental Animals and Diabetes Induction

The test animals were placed 12 rats (Sprague Dawley rat) with an average weight of 280g per group, and dissolved STZ (streptozotocin, A0130, Sigma) in 0.1M citrate buffer (pH 4.0) to 50 kg per rat body weight before the experiment. About 0.2 ml was intraperitoneally injected. Seven days after diabetes-induced injection, mice with a blood glucose level of 300 mg / dl or more were selected by using a glucose measuring device (Medisense Precision Q.I.D., USA). Subjects below the mean blood glucose level were excluded and 10 animals were placed per experimental group.

2. Survey Items and Analysis Methods

Body weight and dietary intake were examined every 7 days. Liver function values (GOT, GPT, total bilirubin) were analyzed by Kinetic UV, and serum lipids (TC, TG, HDL) and blood glucose levels were analyzed by colorimetric analysis using enzymekit. In addition, free fatty acid (FFA) was analyzed by colorimetric method, and ketone body content was analyzed by enzyme method. The experimental results were analyzed using SAS program, and Duncan's multiple test method (a = 0.05) was used to verify the significance between treatment groups.

※ 9/22 (Mon) STZ injection (in 280 g body weight, 0.2 ml injection of 50mg solution)

※ 9/29 (Mon) Test placement considering weight and blood glucose level

※ Start of salary for 10/1 (Wed) Experiment

3. Change in blood sugar

The effects of Hwangja-jara tortoise on blood sugar reduction in diabetic rats are shown in Table 2. The blood glucose level of 7 days after STZ administration was made into reference blood glucose. The baseline blood glucose levels of the diabetic group (A ~ D) were 415.1mg / dL for group A, 326.0mg / dose for B group, 394.1mg / dose for C group, 358.7mg / dose for D group, and 110.8mg / dL for general control group (E). . After 7 weeks of feeding ocherung stark diet (Baegeak Clean Activa), the blood sugar level of the 5% group (A) in the tortoiseshell group (A) dropped to 357.4mg / ㎗, 56.3mg / ㎗, which was 12.9%. 7% of the asterisk and the drink group (C) dropped to 275.6mg / dL after 7 weeks, down to 118.5mg / dL, and the decrease rate was 30.5%, while the diabetic control group increased to 436.8mg / dL, which was 21.1% compared to the reference blood glucose. The general control group (D) decreased slightly from 110.8 mg / dL to 103.4 mg / dL. The changes in blood glucose during the trial are shown in Same as 5. Tortoise 5% group (A) peaked at 452.4 mg / dl at 2 weeks of testing, then dropped to 305.0 mg / dl at 6 weeks, then back to 357.4 mg / dl at week 7, B) peaked at 381.8 mg / dL at 2 weeks, then remained at a similar level, then dropped to 270.4 mg / dL at 5 weeks and slightly increased to 288.1 mg / dL at 7 weeks. Group C, which received dietary supplements and beverages, dropped from 394.1 mg / dL to 252.4 mg / dL per week, then peaked at 309.8 mg / dL for two weeks and 347.7 mg / dL for four weeks. And dropped to 275.6 mg / dl at 7 weeks. The diabetic control group (D) increased to 434.7 mg / mg at 2 weeks and then decreased gradually to 339.9 mg / ㎗ at 6 weeks, but increased to 96.9 mg / ㎗ at 436.8 mg / ㎗ at 7 weeks. D) showed little change in blood glucose level during the test period.

Claims (3)

20-30% Wt of silkworms, 20-30% Wt of mulberry leaves and 30 to 48% Wt of tricalcium phosphate and 1 to 1.9% Wt of sodium silicoalmininate. Low temperature drying at 30 ~ 40 ℃ when hot air drying raw materials. Granulation or capsule solidification.