KR20040053275A - 신규 단백질을 코딩하는 유전자 - Google Patents

신규 단백질을 코딩하는 유전자 Download PDF

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KR20040053275A
KR20040053275A KR10-2004-7006758A KR20047006758A KR20040053275A KR 20040053275 A KR20040053275 A KR 20040053275A KR 20047006758 A KR20047006758 A KR 20047006758A KR 20040053275 A KR20040053275 A KR 20040053275A
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오스카르 첼더
마르쿠스 폼페유스
하르트비히 쉬뢰더
부르크하르트 크뢰거
코린나 클로프로게
그레고르 하버하우어
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Abstract

본 발명은 신규한 핵산 분자, 유전자 변형된 미생물 제조에 있어서의 그의 용도 및 상기 유전자 변형된 미생물을 사용한 정밀 화학물질, 특히 아미노산의 제조 방법에 관한 것이다.

Description

신규 단백질을 코딩하는 유전자 {Gene Which Codes for Novel Proteins}
세포내 천연 대사 과정의 특정 생성물 및 부산물은 식품 산업, 동물 사료 산업, 화장품 산업 및 제약 산업 등을 비롯한 여러 분야의 산업에 이용되고 있다. 정밀 화학물질 (fine chemical)이라고 통칭되는 이들 분자들은 유기산, 단백질성 아미노산 및 비-단백질성 아미노산, 뉴클레오티드 및 뉴클레오시드, 지질 및 지방산, 디올, 탄수화물, 방향족 화합물, 비타민 및 보조인자를 포함하며 효소도 포함한다. 이들은 각 특정 경우마다 원하는 분자를 다량으로 생산하고 분비하도록 개발된 박테리아를 대량 배양함으로써 최고의 생산량으로 생산된다. 이러한 목적에 특히 적합한 유기체는 비-병원성의 그람-양성 박테리아인 코리네박테리움 글루타미쿰 (Corynebacterium glutamicum)이다. 균주 선별을 통해, 각종 바람직한 화합물을 생산하는 수많은 돌연변이체 균주가 개발되어 왔다. 그러나, 특정 분자의 생산과 관련하여 개선된 균주의 선별은 시간 소모적이고 어려운 과정이다.
본 발명에 대한 간단한 설명
본 발명은 코리네박테리움 글루타미쿰 또는 그와 관련된 박테리아 종의 확인 또는 분류에 사용될 수 있는 신규 핵산 분자를 제공한다. 코리네박테리움 글루타미쿰은 수많은 정밀 화학물질의 대량 생산 및 또한 탄화수소 분해 (예를 들어 원유유출 사고의 경우) 및 테르페노이드의 산화와 관련된 산업에 광범위하게 이용되는 그람-양성 호기성 박테리아이다. 따라서, 상기 핵산 분자는 예를 들어 발효 공정에 의한 정밀 화학물질의 생산에 사용될 수 있는 미생물을 확인하는데 이용될 수 있다. 코리네박테리움 글루타미쿰 자체는 병원성이 아니지만, 코리네박테리움 디프테리애 (Corynebacterium diphtheriae) (디프테리아 병원체) 등과 같은 기타 관련 코리네박테리움 종은 인간에서의 주요 병원체이다. 따라서, 코리네박테리움 종의 존재 확인력은 예를 들어 진단 용도 등에서의 임상적 중요성이 상당할 수도 있다. 추가로, 상기 핵산 분자는 코리네박테리움 글루타미쿰 게놈 또는 그와 관련된 유기체의 게놈 맵핑을 위한 기준점으로 작용할 수도 있다.
이들 신규 핵산 분자는 본원에서 마커- 및 정밀 화학물질-생산 (MCP;Marker- 및 fineChemical-Producing) 단백질이라고 지칭하는 단백질을 코딩한다. 이러한 MCP 단백질은 예를 들어 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산에 직접 또는 간접적으로 관여할 수 있다. 또한, 본 발명의 MCP 단백질은 탄화수소의 분해 또는 테르페노이드의 산화에도 관여할 수 있다. 상기 단백질을 사용하여 코리네박테리움 글루타미쿰 또는 코리네박테리움 글루타미쿰과 관련이 있는 유기체를 확인할 수 있는데, 단백질 혼합물 중에 코리네박테리움 글루타미쿰 및 그와 관련된 종에 특이적인 MCP 단백질이 존재하는 것은 그 샘플 중에 상기 박테리아 중 임의의 것이 존재함을 지시하는 것일 수 있다. 추가로, 이러한 MCP 단백질은 식물 또는 동물에서 질환 상태 또는 질병에 관여하는 상동체가 있을 수 있기 때문에, 이러한 단백질은 약물 스크리닝 및 치료용 화합물의 개발에 유용한 제약상 표적으로 작용할 수 있다.
예를 들어 신스키 (Sinskey) 등의 미국 특허 제4,649,119호에 개시된 바와 같은 코리네박테리움 글루타미쿰에 사용할 수 있는 클로닝 벡터를 입수할 수 있으며 코리네박테리움 글루타미쿰 및 관련 브레비박테리움 (Brevibacterium) 종 (예를 들어 락토페르멘툼 (lactofermentum))의 유전자 조작에 이용한 기술 ([Yoshihama et al., J. Bacteriol. 162:591-597 (1985)], [Katsumata et al., J. Bacteriol. 159:306-311 (1984)] 및 [Santamaria et al. J. Gen. Microbiol. 130:2237-2246 (1984))])을 이용할 수 있으므로, 본 발명의 핵산 분자를 상기 유기체의 유전자 조작에 이용하여 1종 이상의 정밀 화학물질의 생산을 조정할 수 있다. 이는 본 발명의 유전자 조작의 직접적인 효과 또는 그러한 조작의 간접적인 효과에 의해 조정되는 것일 수 있다. 예를 들면, 정밀 화학물질의 생합성 또는 분해에 관여하는 단백질의 활성을 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)시켜 세포에 의한 상기 화합물의 합성능 또는 분해능을 직접 조정함으로써, 정밀 화학물질의 수율 및(또는) 생산 효율을 조정할 수 있다. 또한, 정밀 화학물질의 대사 경로를 조절하는 단백질의 활성을 조정하여 원하는 화합물의 생산을 상향 또는 하향 조절함으로써 두 경우 모두에서 세포로부터의 정밀 화학물질 수율 또는 생산 효율이 조정되도록 직접적인 영향을 미칠 수 있다.
정밀 화학물질 생산의 간접 조정은 본 발명에 따른 단백질의 활성 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)에 의해 수행되어, 세포의 성장력 및 분열력 또는 살아있는 상태로의 유지력 또는 생산성 유지력을 전반적으로 증가시킬수도 있다. 통상적으로, 코리네박테리움 글루타미쿰으로부터의 정밀 화학물질 생산은 상기 미생물을 종종 세포 성장 및 세포 분열에 최적인 상태에 준하는 (suboptimal) 조건하에 대량으로 발효 배양함으로써 수행된다. 본 발명의 단백질 (예를 들어 스트레스 반응 단백질, 세포벽 단백질 또는 뉴클레오티드 및 아미노산 등과 같이 세포 분열 및 세포 성장 수행에 필요한 화합물의 대사에 관여하는 단백질)을 변형시켜 상기 조건하에서의 생존, 성장 및 전파를 개선시킴으로써, 상기 변형된 코리네박테리움 글루타미쿰 세포의 대량 배양시의 수 및 생산성이 증가되도록 할 수 있는데, 이는 1종 이상의 원하는 정밀 화학물질의 수율 및(또는) 생산 효율을 증가시키는 것이다. 추가로, 세포의 대사 경로는 반드시 상호 의존적이고 동시 조절되는 것이다. 코리네박테리움 글루타미쿰의 임의의 대사 경로에서의 활성을 변화시킴 (즉, 그러한 경로에 관여하는 본 발명의 단백질들 중 하나의 활성을 변화시킴)으로써 상기 미생물에서 정밀 화학물질의 합성 또는 분해에 직접적으로 관여할 수 있는 또다른 대사 경로의 활성 또는 그에 대한 조절을 동시에 변화시킬 수 있다.
본 발명은 본원에서 MCP 단백질이라고 지칭하고 예를 들어 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있는 단백질을 코딩하는 신규 핵산 분자를 제공한다. 본원에서는 MCP 단백질을 코딩하는 핵산 분자를 MCP 핵산 분자라고 지칭한다. 바람직한 실시양태에서, MCP 단백질은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다. 이러한 단백질의 예로는 표 1에 기재한 유전자에 의해 코딩되는 단백질이 있다
따라서, 본 발명의 한 측면은 MCP 단백질 또는 그의 생물학적 활성 절편을 코딩하는 뉴클레오티드 서열을 포함하고 MCP-코딩 핵산 (예컨대 DNA 또는 mRNA)을 검출하거나 증폭시키기 위한 프라이머 또는 혼성화 프로브로서 적합한 핵산 단편도 포함하는 단리된 핵산 분자 (예컨대 cDNA)에 관한 것이다. 특히 바람직한 실시양태에서, 단리된 핵산 분자는 첨부문서 (Appendix) A에 기재한 임의의 뉴클레오티드 서열 또는 이러한 핵산 서열 중 임의의 서열의 코딩 영역 또는 그의 상보체를 포함한다. 다른 바람직한 실시양태에서, 단리된 핵산 분자는 첨부문서 B에 기재한 아미노산 서열 중 하나를 코딩한다. 또한, 본 발명의 바람직한 MCP 단백질은 본원에 기재한 MCP 활성을 바람직하게는 하나 이상 보유한다.
하기에서, 첨부문서 A는 표 1에서 해당 위치에서의 서열 변형과 함께 기재한 핵산 서열을 규정한다.
하기에서, 첨부문서 B는 표 1에서 해당 위치에서의 서열 변형과 함께 기재한 폴리펩티드 서열을 규정한다.
추가의 실시양태에서, 단리된 핵산 분자는 뉴클레오티드 15개 이상의 길이이며 엄격 조건하에서 첨부문서 A의 뉴클레오티드 서열을 포함하는 핵산 분자와 혼성화된다. 바람직하게는, 단리된 핵산 분자는 천연 핵산 분자에 상응한다. 더욱 바람직하게는, 단리된 핵산은 천연 코리네박테리움 글루타미쿰 MCP 단백질 또는 그의생물학적 활성 절편을 코딩한다.
본 발명의 또다른 측면은 벡터, 예를 들어 본 발명의 핵산 분자를 함유하는 재조합 발현 벡터 및 상기 벡터가 도입된 숙주 세포에 관한 것이다. 한 실시양태에서, MCP 단백질은 적합한 배지 중에서 배양한 숙주 세포를 사용하여 제조된다. 이후에, 상기 배지 또는 숙주 세포로부터 MCP 단백질을 단리할 수 있다.
본 발명의 또다른 측면은 MCP 유전자가 도입되었거나 MCP 유전자가 변형됨으로써 유전자 변형된 미생물에 관한 것이다. 한 실시양태에서, 상기 미생물의 게놈은 돌연변이된 MCP 서열을 코딩하는 1종 이상의 본 발명의 핵산 분자를 트랜스진 (transgene)으로서 도입함으로써 변형된다. 또다른 실시양태에서, 상기 미생물 게놈 내의 내인성 MCP 유전자는 변형된 MCP 유전자와의 상동성 재조합에 의해 변형, 예를 들어 기능적으로 파괴된다. 바람직한 실시양태에서, 상기 미생물은 코리네박테리움 속 또는 브레비박테리움 속에 포함되며, 코리네박테리움 글루타미쿰인 것이 특히 바람직하다. 또한, 바람직한 실시양태에서는 상기 미생물을 이용하여 아미노산, 특히 바람직하게는 리신 등과 같은 관심 화합물을 제조한다.
또다른 바람직한 실시양태는 첨부문서 A에 기재한 핵산 분자를 1종 초과로 보유하는 숙주 세포이다. 이러한 숙주 세포는 당업자에게 공지된 여러 방법으로 제조할 수 있다. 이들은 예를 들어 본 발명의 핵산 분자를 여러개 운반하는 벡터로 형질감염될 수 있다. 그러나, 각 경우에 벡터를 이용하여 본 발명의 한 핵산 분자를 숙주 세포에 도입할 수 있기 때문에, 복수개의 벡터를 동시에 또는 순차적으로 이용할 수도 있다. 따라서, 수백 종에 이르는 수많은 본 발명의 핵산 서열을운반하는 숙주 세포를 제작할 수 있다. 이러한 축적은 종종 숙주 세포에서 정밀 화학물질의 생산성과 관련된 부수적인 효과를 초래할 수 있다.
본 발명의 또다른 측면은 단리된 MCP 단백질 또는 그의 절편, 예를 들어 그의 생물학적 활성 절편에 관한 것이다. 바람직한 실시양태에서, 단리된 MCP 단백질 또는 그의 절편은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다. 또다른 바람직한 실시양태에서, 단리된 MCP 단백질 또는 그의 절편은 첨부문서 B의 아미노산 서열에 충분한 상동성이 있어서, 상기 단백질 또는 그의 절편이 예를 들어 여전히 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다.
추가로, 본 발명은 단리된 MCP 단백질 제제에 관한 것이다. 바람직한 실시양태에서, MCP 단백질은 첨부문서 B의 아미노산 서열을 포함한다. 추가의 바람직한 실시양태에서, 본 발명은 첨부문서 B의 완전 아미노산 서열 (첨부문서 A의 오픈 리딩 프레임에 의해 코딩됨)에 본질적으로 상동성이 있는 단리된 전장 단백질에 관한 것이다.
MCP 폴리펩티드 또는 그의 생물학적 활성 절편은 비-MCP 폴리펩티드와 기능적으로 연결되어 융합 단백질을 형성할 수 있다. 바람직한 실시양태에서, 이 융합 단백질은 MCP 단백질 단독과는 활성이 상이하다. 다른 바람직한 실시양태에서, 상기 융합 단백질은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다. 특히 바람직한 실시양태에서, 숙주 세포로의 상기 융합 단백질 통합이 세포에 의한 관심 화합물의 생산을 조정한다.
본 발명의 또다른 측면은 정밀 화학물질의 제조 방법에 관한 것이다. 상기 방법은 본 발명의 MCP 핵산 분자를 발현시켜 정밀 화학물질이 생산되도록 하는 벡터를 함유하는 세포를 배양하는 단계를 포함한다. 바람직한 실시양태에서, 상기 방법은 MCP 핵산을 발현시키는 벡터로 형질감염되어 이러한 벡터를 함유하는 세포를 수득하는 단계를 추가로 포함한다. 추가의 바람직한 실시양태에서, 상기 방법은 배양물로부터 정밀 화학물질을 수득하는 단계를 추가로 포함한다. 특히 바람직한 실시양태에서, 상기 세포는 코리네박테리움 속 또는 브레비박테리움 속에 속한다.
본 발명의 또다른 측면은 미생물로부터의 분자 생산을 조정하는 방법에 관한 것이다. 상기 방법은 세포를 MCP 단백질 활성 또는 MCP 핵산의 발현을 조정하는 물질로서 그의 존재하에서는 세포의 관련 활성이 그의 부재하에서의 동일 활성과 비교할 때 변형되는 물질과 접촉시키는 단계를 포함한다. 바람직한 실시양태에서는, 세포에서 1종 이상의 코리네박테리움 글루타미쿰 MCP 단백질 활성을 조정하여, 상기 미생물에 의한 관심 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 개선시킨다. MCP 단백질 활성을 조정하는 물질은 MCP 단백질 활성 또는 MCP 핵산의발현을 자극하는 물질일 수 있다. 상기 MCP 단백질 활성 또는 MCP 핵산의 발현을 자극하는 물질의 예로는 소분자, 활성 MCP 단백질 및 MCP 단백질을 코딩하는 핵산 등이 있으며, 이들을 세포에 도입한다. MCP 활성 또는 MCP 발현을 억제하는 물질의 예로는 소분자 및 안티센스 MCP 핵산 분자 등이 있다.
본 발명의 또다른 측면은 MCP 야생형 유전자 또는 MCP-돌연변이 유전자를 세포에 도입하여 상기 유전자가 별개의 플라스미드에 유지되거나 숙주 세포의 게놈에 통합되도록 하는 단계를 포함하는, 세포로부터의 관심 화합물의 수율, 생산량 및(또는) 생산 효율을 조정하는 방법에 관한 것이다. 게놈으로의 통합은 무작위로 발생하거나 상동성 재조합을 통해 발생하여, 천연 유전자가 세포에 의한 관심 화합물 생산이 조정되도록 하는 통합된 카피 (copy)로 대체되도록 할 수 있다. 바람직한 실시양태에서는 수율이 증가한다. 또다른 바람직한 실시양태에서, 상기 화학물질은 정밀 화학물질이고, 특히 바람직한 실시양태에서는 아미노산이다. 특히 바람직한 실시양태에서, 상기 아미노산은 L-리신이다.
본 발명은 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체의 확인, 코리네박테리움 글루타미쿰 게놈 (또는 밀접한 관련이 있는 유기체의 게놈)의 맵핑 또는 발효 공정 등을 통해 정밀 화학물질의 생산에 이용할 수 있는 미생물을 확인하는데 사용할 수 있는 MCP 핵산 및 MCP 단백질 분자를 제공한다. 상기 핵산에 의해 코딩되는 단백질은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 직접 또는 간접적으로 조정하는데 이용하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 이용하거나, 테르페노이드의 산화 또는 탄화수소의 분해에 이용하거나 또는 치료용 제약 화합물을 개발하기 위한 표적으로서 이용할 수 있다. 본 발명의 측면에 대해서는 하기에서 추가로 설명한다.
I. 정밀 화학물질
용어 "정밀 화학물질"은 당업계에 공지되어 있고 유기체에 의해 생산되는 분자를 포함하며, 제약 산업, 농업 및 화장품 산업 등을 포함하나 이에 제한되지 않는 각종 분야의 산업에서 이용된다. 이러한 화합물로는 유기산, 예컨대 타르타르산, 이타콘산 및 디아미노피멜산, 단백질성 및 비-단백질성 아미노산, 퓨린 및 피리미딘 염기, 뉴클레오시드 및 뉴클레오티드 (예를 들어 문헌 [Kuninaka, A. (1996) Nucleotides and related compounds, pp. 561-612, in Biotechnology Vol. 6, Rehm et al., Editors VCH: Weinheim]과 그의 참고문헌에 기재된 바와 같음), 지질, 포화 및 불포화 지방산 (예컨대 아라키돈산), 디올 (예컨대 프로판디올 및 부탄디올), 탄수화물 (예컨대 하이알루론산 및 트레할로스), 방향족 화합물 (예컨대 방향족 아민, 바닐린 및 인디고), 비타민 및 보조인자 (문헌 ([Ullmann's Encyclopedia of Industrial Chemistry, Vol. A27, "Vitamins", pp. 443-613 (1996) VCH: Weinheim]과 그의 참고문헌 및 문헌 [Ong, A.S., Niki, E. and Packer, L. (1995) "Nutrition, Lipids, Health and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia and the Society for Free Radical Research - Asia, held Sept. 1-3, 1994, inPenang, Malaysia, AOCS Press (1995)]에 기재된 바와 같음), 문헌 [Gutcho (1983), Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086] 및 상기 문헌에 표시된 참고문헌에 기재된 효소 및 모든 기타 화학물질 등이 있다. 특정 정밀 화학물질의 대사 및 용도는 하기에서 추가로 설명한다.
A. 아미노산의 대사 및 용도
아미노산은 모든 단백질의 기본적인 구조 단위를 포함하기 때문에, 모든 유기체에서의 정상적인 세포 기능에 필수적이다. 용어 "아미노산"은 당업계에 공지되어 있다. 단백질성 아미노산에는 20종의 유형이 있으며 단백질의 구조 단위로서 작용하고 펩티드 결합에 의해 함께 연결되는 반면, 비-단백질성 아미노산 (수백종이 공지되어 있음)은 통상적으로 단백질 내에 존재하지 않는다 (문헌 [Ullmann's Encyclopedia of Industrial Chemistry, Vol. A2, pp. 57-97 VCH: Weinheim (1985)] 참조). 아미노산은 광학적 D 또는 L 배위로 존재할 수 있지만, 천연 단백질에 존재하는 것은 통상적으로 L-아미노산 뿐이다. 20종의 단백질성 아미노산 각각의 생합성 및 분해 경로는 원핵 세포 및 진핵 세포 둘다에 대하여 특징규명되어 있다 (예를 들어 문헌 [Stryer, L. Biochemistry, 3rdedition, pp. 578-590 (1988)] 참조). 생합성의 복잡성으로 인해 통상적으로 식품을 통해 섭취해야 하기 때문에 "필수 아미노산"이라 불리는 아미노산 (히스티딘, 이소루이신, 루이신, 리신, 메티오닌, 페닐알라닌, 트레오닌, 트립토판 및 발린)은 단순한 생합성 경로를 통해 다른 11종의 "비필수" 아미노산 (알라닌, 아르기닌, 아스파라긴, 아스파르테이트, 시스테인, 글루타메이트, 글루타민, 글리신, 프롤린, 세린 및 티로신)으로 전환된다. 고등 동물은 이러한 아미노산 중 일부를 합성할 수 있으나, 통상의 단백질 합성이 일어나도록 하려면 필수 아미노산은 음식물로 섭취해야 한다.
이러한 아미노산은 단백질 생합성에서의 기능 이외에도 이와 같이 흥미로운 화학물질이며, 많은 아미노산들이 인간용 식료품, 동물 사료, 화학물질, 화장품, 농업 및 제약 산업에서 여러가지 용도를 갖는다는 것이 밝혀졌다. 리신은 인간 영양 뿐 아니라 가금류 및 돼지 등과 같은 단위 (monogastric) 가축에 있어서도 중요한 아미노산이다. 글루타메이트는 향미성 첨가제 (일나트륨 글루타메이트, MSG)로서 가장 흔히 사용되며, 그밖의 식품 산업에 사용되는 것은 아스파르테이트, 페닐알라닌, 글리신 및 시스테인이다. 글리신, L-메티오닌 및 트립토판은 모두가 제약 산업에 사용된다. 글루타민, 발린, 루이신, 이소루이신, 히스티딘, 아르기닌, 프롤린, 세린 및 알라닌은 제약 산업 및 화장품 산업에 사용된다. 트레오닌, 트립토판 및 D/L-메티오닌은 동물 사료 첨가제에 광범위하게 사용된다 [Leuchtenberger, W. (1996) Amino acids - technical production and use, pp. 466-502 in Rehm et al., (editors) Biotechnology Vol. 6, Chapter 14a, VCH: Weinheim]. 추가로, 이러한 아미노산은 합성 아미노산 및 단백질을 합성하기 위한 전구체, 예를 들어 N-아세틸시스테인, S-카르복시메틸-L-시스테인, (S)-5-히드록시트립토판 및 문헌 [Ullmann's Encyclopedia of Industrial Chemistry, Vol. A2, pp. 57-97, VCH, Weinheim, 1985]에 기재된 기타 물질로서 적합한 것으로 밝혀졌다.
박테리아 등과 같이 이러한 천연 아미노산을 생산할 수 있는 유기체에서의이들의 생합성은 자세하게 특징규명되어 있다 (박테리아 아미노산 생합성 및 그의 조절에 관해 검토하기 위해서는 문헌 [Umbarger, H.E. (1978) Ann. Rev. Biochem. 47:533-606] 참조). 글루타메이트는 시트르산 사이클의 중간체인 α-케토글루타레이트의 환원적 아미노화로 합성된다. 글루타민, 프롤린 및 아르기닌 각각은 글루타메이트로부터 연속적으로 생성된다. 세린의 생합성은 3-단계 과정으로 일어나며, 3-포스포글리세레이트 (해당작용의 중간체)로 출발하여 산화, 아미노 교환반응 및 가수분해 단계 이후에 세린이 된다. 시스테인 및 글리신 각각은 세린으로부터 생성되지만, 특이한 점은 시스테인은 호모시스테인과 세린의 축합으로 생성되고, 글리신은 세린 트랜스히드록시메틸라제에 의해 촉매되는 반응에서 측쇄 β-탄소 원자가 테트라히드로폴레이트에 전달되어 생성된다는 점이다. 페닐알라닌 및 티로신은 해당작용과 펜토스 포스페이트 경로의 전구체인 에리트로스 4-포스페이트와 포스포에놀피루베이트로부터 9-단계 생합성 경로를 거쳐 합성되는데, 이는 프레페네이트가 합성된 후의 마지막 2개 단계만이 다르다. 또한, 트립토판도 이러한 2종의 출발 분자로부터 생산되지만 11-단계 경로로 합성된다. 티로신 역시 페닐알라닌 히드록실라제가 촉매하는 반응을 통해 페닐알라닌으로부터 제조될 수 있다. 알라닌, 발린 및 루이신 각각은 해당작용의 최종 생성물인 피루베이트로부터 유도되는 생합성 생성물이다. 아스파르테이트는 시트레이트 사이클의 중간체인 옥살아세테이트로부터 형성된다. 아스파라긴, 메티오닌, 트레오닌 및 리신 각각은 아스파르테이트의 전환으로 생성된다. 이소루이신은 트레오닌으로부터 형성된다. 히스티딘은 활성화된 당인 5-포스포리보실 1-피로포스페이트로부터 복잡한 9-단계 경로로형성된다.
단백질 생합성에서의 필요량을 초과하는 양의 아미노산은 저장될 수 없으며, 그 대신에 분해되어 세포의 주요 대사 경로에 중간체로서 제공된다 (검토하기 위해서는 문헌 [Stryer, L., Biochemistry, 3rdedition, Chapter 21 Amino Acid Degradation and the Urea Cycle"; pp. 495-516 (1988)] 참조). 세포가 원치않는 아미노산을 대사에 유용한 중간체로 전환시킬 수는 있지만, 아미노산 생산은 그의 합성에 필요한 에너지, 전구체 분자 및 효소를 고려할 때 고가이다. 따라서, 아미노산 생합성이 피드백 (feedback) 억제에 의해 조절되어 특정 아미노산의 존재가 그 아미노산 자체의 생산을 저하시키거나 완전하게 중단시킨다는 것은 놀라운 일이 아니다 (아미노산 생합성 경로의 피드백 메카니즘에 대해 검토하기 위해서는 문헌 [Stryer, L., Biochemistry, 3rdedition, Chapter 24, "Biosynthesis of Amino acids and Heme", pp. 575-600 (1988)] 참조). 따라서, 특정 아미노산의 생산량은 세포 내에 존재하는 해당 아미노산의 양에 의해 제한된다.
B. 비타민, 보조인자 및 영양제 (nutraceutical)의 대사 및 용도
비타민, 보조인자 및 영양제는 또다른 군의 분자를 포함한다. 고등 동물은 이들에 대한 합성 능력이 없기 때문에 섭취해야만 하지만, 박테리아 등과 같은 다른 유기체는 이들을 쉽게 합성한다. 이들 분자는 그 자체가 생물활성 분자이거나 수많은 대사 경로에서 전자 운반체 또는 중간체로 작용하는 생물활성 물질의 전구체이다. 이들 화합물에는 영양학적 가치 뿐 아니라 착색제, 항산화제 및 촉매 또는 기타 가공 보조제로서 유의한 산업적 가치도 있다 (이들 화합물의 구조, 활성 및 산업적 용도를 검토하기 위해서는 예를 들어 문헌 [Ullmann's Encyclopedia of Industrial Chemistry, "Vitamins", Vol. A27, pp. 443-613, VCH: Weinheim, 1996] 참조). 용어 "비타민"은 당업계에 공지되어 있으며, 유기체의 정상적인 기능수행에는 필요하지만 이러한 유기체 자체로는 합성하지 못하는 영양소를 포함한다. 비타민군은 보조인자 및 영양제 화합물을 포함할 수 있다. 용어 "보조인자"는 정상적인 효소 활성을 나타내는데 필요한 비-단백질성 화합물을 포함한다. 이들 화합물은 유기 또는 무기일 수 있다. 본 발명의 보조인자 분자는 유기인 것이 바람직하다. 용어 "영양제"는 식물 및 동물, 특히 인간의 건강을 증진시키는 식품 첨가제를 포함한다. 이러한 분자의 예로는 비타민, 항산화제 및 또한 특정 지질 (예컨대 다중불포화 지방산) 등이 있다.
박테리아 등과 같이 이러한 분자를 생산할 수 있는 유기체에서의 이들의 생합성은 포괄적으로 특징규명되어 있다 [Ullmann's Encyclopedia of Industrial Chemistry, "Vitamins", Vol. A27, pp. 443-613, VCH: Weinheim, 1996], [Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley ＆ Sons], [Ong, A.S., Niki, E. and Packer, L. (1995) "Nutrition, Lipids, Health and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia and the Society for free Radical Research - Asia, held on Sept. 1-3, 1994, in Penang, Malaysia, AOCS Press, Champaign, IL X, 374 S].
티아민 (비타민 B1)은 피리미딘 및 티아졸 단위의 화학적 커플링으로 형성된다. 리보플라빈 (비타민 B2)은 구아노신 5'-트리포스페이트 (GTP) 및 리보스 5'-포스페이트로부터 합성된다. 이후, 리보플라빈은 플라빈 모노뉴클레오티드 (FMN) 및 플라빈 아데닌 디뉴클레오티드 (FAD)의 합성에 이용된다. "비타민 B6"라고 통칭되는 군의 화합물들 (예컨대 피리독신, 피리독스아민, 피리독살 5'-포스페이트 및 시판되는 피리독신 히드로클로라이드)은 모두가 공통적인 구조 단위인 5-히드록시-6-메틸피리딘의 유도체이다. 판토테네이트 (판토텐산, R-(+)-N-(2,4-디히드록시-3,3-디메틸-1-옥소부틸)-β-알라닌)은 화학적 합성 또는 발효를 통해 제조될 수 있다. 판토테네이트 생합성에서의 마지막 단계는 β-알라닌 및 판토산이 ATP-구동되어 축합되는 것으로 이루어진다. 판토산으로의 전환과 β-알라닌으로의 전환 및 판토텐산으로의 축합에 대한 생합성 단계를 담당하는 효소는 공지되어 있다. 판토테네이트의 대사 활성 형태는 5가지 효소 단계로 생합성되는 조효소 A이다. 판토테네이트, 피리독살 5'-포스페이트, 시스테인 및 ATP가 조효소 A의 전구체이다. 이러한 효소는 판토테네이트의 형성 뿐 아니라 (R)-판토산, (R)-판토락톤, (R)-판테놀 (프로비타민 B5), 판테테인 (및 그의 유도체) 및 조효소 A의 생산까지도 촉매한다.
미생물에서 전구체 분자인 피멜로일-CoA로부터 바이오틴이 생합성되는 과정은 상세하게 연구되어 왔으며, 이에 관여하는 여러개의 유전자가 확인되었다. 여러가지 상응하는 단백질들이 Fe 클러스터 합성에 관여하며 nifS 단백질 클래스에속한다는 것이 밝혀졌다. 리폰산은 옥탄산에서 유도되어 에너지 대사의 조효소로 작용하며 피루베이트 데히드로게나제 복합체 및 α-케토글루타레이트 데히드로게나제 복합체의 성분이다. 폴레이트는 L-글루탐산, p-아미노벤조산 및 6-메틸프테린으로부터 유도되는 엽산에서 유도되는 모든 물질들의 군이다. 구아노신 5'-트리포스페이트 (GTP), L-글루탐산 및 p-아미노벤조산의 생체내변환의 중간체로부터 출발하는 엽산 및 그의 유도체의 생합성은 특정 미생물에서 상세하게 연구되어 왔다.
코리노이드 (예컨대 코발라민 및 특히 비타민 B12) 및 포르피린은 테트라피롤 고리계로 구별되는 화학물질들의 군에 속한다. 비타민 B12의 생합성은 매우 복잡하여 완전하게 특징규명되지 못했으나, 이에 관여하는 많은 효소 및 기질이 현재 공지되어 있다. 니코틴산 (니코티네이트) 및 니코틴아미드는 "니아신"이라고도 지칭되는 피리딘 유도체이다. 니아신은 중요한 조효소인 NAD (니코틴아미드 아데닌 디뉴클레오티드) 및 NADP (니코틴아미드 아데닌 디뉴클레오티드 포스페이트) 및 이들의 환원 형태의 전구체이다.
리보플라빈, 비타민 B6, 판토테네이트 및 바이오틴 등과 같은 이들 화학물질 중 일부는 미생물의 대량 배양으로 생산되기도 하지만, 이들 화합물의 산업적 규모의 생산은 대부분이 무(無)세포 화학적 합성을 기초로 한다. 오직 비타민 B12만이 그의 복잡한 합성법으로 인해 발효에 의해서만 생산된다. 시험관내 공정에는 상당한 재료 및 시간 소요가 요구되며, 종종 고가이다.
C. 퓨린, 피리미딘, 뉴클레오시드 및 뉴클레오티드의 대사 및 용도
퓨린 및 피리미딘 대사 유전자 및 이들의 상응하는 단백질은 종양증 및 바이러스 감염의 치료에 중요한 표적이다. 용어 "퓨린" 또는 "피리미딘"은 핵산, 조효소 및 뉴클레오티드의 일부를 형성하는 질소-함유 염기를 포함한다. 용어 "뉴클레오티드"는 핵산 분자의 기본적인 구조 단위를 포괄하며, 질소-함유 염기, 펜토스 당 (RNA의 경우에는 상기 당이 리보스이고, DNA의 경우에는 상기 당이 D-데옥시리보스임) 및 인산을 포함한다. 용어 "뉴클레오시드"는 뉴클레오티드의 전구체로서 작용하는 분자를 포함하지만, 뉴클레오티드와는 달리 인산 단위는 보유하지 않는다. 이들 분자가 생합성되는 과정이나 이들이 동원되어 핵산 분자를 형성하는 과정을 억제함으로써 RNA 및 DNA 합성을 억제할 수 있다. 암 세포에서 이러한 활성 억제를 표적으로 하면 종양 세포의 분열력 및 복제력을 억제할 수 있다. 또한, 핵산 분자를 형성하지 않고 에너지 저장물 (즉, AMP) 또는 조효소 (즉, FAD 및 NAD)로서 작용하는 뉴클레오티드도 존재한다.
이들 화학물질이 퓨린 및(또는) 피리미딘 대사에 영향을 줌으로써 이러한 의학적 조치에 사용될 수 있다는 것은 여러 간행물에 기재된 바 있다 (예를 들어 문헌 [Christopherson, R. I. and Lyons, S. D. (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents. "Med. Res. Reviews 10:505-548]). 퓨린 및 피리미딘 대사에 관여하는 효소에 대한 연구는 예를 들어 면역저해제 또는 항-증식제 등으로 이용할 수 있는 신약의 개발에 집중되어 왔다 ([Smith, J.L. "Enzymes in Nucleotide Synthesis" Curr. Opin. Struct. Biol. 5 (1995) 752-757], [Biochem. Soc. Transact. 23 (1995) 877-902]). 그러나, 퓨린 및 피리미딘 염기, 뉴클레오시드 및 뉴클레오티드는 각종 정밀 화학물질의 생합성에서 중간체 (예컨대 티아민, S-아데노실메티오닌, 폴레이트 또는 리보플라빈)로서의 용도, 세포의 에너지 운반체 (예컨대 ATP 또는 GTP)로서의 용도 및 통상적으로 향미 증진제로서 사용되는 화학물질 자체 (예컨대 IMP 또는 GMP)로서의 용도 또는 많은 의학적 용도 (예를 들어 문헌 [Kuninaka, A., (1996) "Nucleotides and Related Compounds in Biotechnology" Vol. 6, Rehm et al., editors VCH: Weinheim, pp. 561-612] 참조) 등을 비롯한 다른 용도에도 가능하다. 퓨린, 피리미딘, 뉴클레오시드 또는 뉴클레오티드 대사에 관여하는 효소는 살진균제, 제초제 및 살곤충제 등을 비롯하여 작물 보호용으로 개발되고 있는 화학물질을 위한 표적으로 점점 더 크게 기능하고 있다.
박테리아에서 이들 화합물의 대사는 특징규명되어 있다 (검토하기 위해서는 예를 들어 문헌 [Zalkin, H. and Dixon, J.E. (1992) "De novo purine nucleotide biosynthesis" in Progress in Nucleic Acids Research and Molecular Biology, Vol. 42, Academic Press, pp. 259-287] 및 [Michal, G. (1999) Nucleotides and Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley, New York] 참조). 집중적인 연구 대상인 퓨린 대사는 세포의 정상적인 기능수행에 필수적이다. 고등 동물에서의 퓨린 대사 장애는 통풍 등과 같은 심각한 질병을 일으킬 수 있다. 퓨린 뉴클레오티드는 리보스 5'-포스페이트로부터 중간체 화합물인 이노신 5'-포스페이트 (IMP)를 거치는 수많은 단계를 통해 합성되어 구아노신 5'-모노포스페이트 (GMP) 또는 아데노신 5'-모노포스페이트 (AMP)를 생성하고, 이로부터 뉴클레오티드로서 사용되는 트리포스페이트 형태가 쉽게 제조될 수 있다. 이들 화합물은 에너지 저장물로도 사용되어, 이들의 분해는 세포의 여러가지 상이한 생화학적 과정을 위한 에너지를 제공한다. 피리미딘 생합성은 리보스 5'-포스페이트로부터의 유리딘 5'-모노포스페이트 (UMP) 형성을 통해 일어난다. 이후, UMP는 시티딘 5'-트리포스페이트 (CTP)로 전환된다. 모든 뉴클레오티드의 데옥시 형태는 뉴클레오티드의 디포스페이트 리보스 형태로부터의 1-단계 환원 반응으로 제조되어 뉴클레오티드의 디포스페이트 데옥시리보스 형태를 생성한다. 이들 분자는 인산화 후에 DNA 합성에 이용될 수 있다.
D. 트레할로스 대사 및 용도
트레할로스는 α,α-1,1 연결기를 통해 함께 연결된 2개의 글루코스 분자로 구성된다. 이는 통상적으로 감미료, 건조 또는 동결 식품용 첨가제로서 식품 산업에 사용되고 음료 산업에 사용된다. 그러나, 이들은 제약 산업 또는 화장품 산업 및 생명공학 산업에서도 이용된다 (예를 들어, 니시모또 (Nishimoto) 등의 미국 특허 제5,759,610호 (1998), [Singer, M.A. and Lindquist, S. Trends Biotech. 16 (1998) 460-467], [Paiva, C.L.A. and Panek, A.D. Biotech Ann. Rev. 2 (1996) 293-314] 및 [Shiosaka, M. J. Japan 172 (1997) 97-102] 참조). 트레할로스는 많은 미생물의 효소에 의해 생산되어 주변 배지에 자연적으로 방출되며, 이로부터 트레할로스를 당업계에 공지된 방법으로 단리해 낼 수 있다.
II. 본 발명의 요소 및 방법
본 발명은 적어도 부분적으로는 본원에서 MCP 핵산 분자라고 지칭하는 신규분자의 검출을 기초로 한다. 이러한 MCP 핵산 분자는 코리네박테리움 글루타미쿰 또는 그와 관련된 박테리아 종의 확인에 적합할 뿐 아니라 코리네박테리움 글루타미쿰 게놈의 맵핑을 위한 마커 및 발효 공정 등을 통한 정밀 화학물질의 생산에 적합한 박테리아의 확인에도 적합하다. 또한, 본 발명은 적어도 부분적으로는 상기 MCP 핵산 분자에 의해 코딩되는 MCP 단백질 분자를 기초로 한다. 이러한 MCP 분자는 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정할 수 있고 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있고 탄화수소를 분해할 수 있으며 치료용 제약 화합물의 개발을 위한 표적으로 작용할 수 있다. 한 실시양태에서, 본 발명의 MCP 분자는 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 대사 경로에 직접 또는 간접적으로 관여한다. 바람직한 실시양태에서, 이러한 대사 경로에 간접 또는 직접적으로 관여하는 본 발명의 MCP 분자의 작용은 상기 미생물에 의한 관심 정밀 화학물질의 생산에 영향을 미친다. 특히 바람직한 실시양태에서, 본 발명의 MCP 분자의 활성을 조정하여 본 발명의 MCP 단백질이 관여하는 코리네박테리움 글루타미쿰 대사 경로의 효율 또는 생산량을 조정하는데, 이는 코리네박테리움 글루타미쿰에 의한 관심 정밀 화학물질의 생산량 또는 생산 효율을 직접 또는 간접적으로 조정한다.
용어 "MCP 단백질" 또는 "MCP 폴리펩티드"는 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정할 수 있고 탄화수소를 분해할 수 있고 테르페노이드를 산화시킬 수 있으며 약물 스크리닝 또는 약물 고안을 위한 표적 단백질로 작용하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있는 단백질을 포함한다. MCP 단백질의 예로는 표 1 및 첨부문서 A에 기재한 MCP 유전자에 의해 코딩되는 단백질 등이 있다. 용어 "MCP 유전자" 및 "MCP 핵산 서열"은 MCP 단백질을 코딩하며 코딩 영역 및 상응하는 비번역 5' 및 3' 서열 영역을 포함하는 핵산 서열을 포함한다. MCP 유전자의 예로는 표 1에 기재한 유전자가 있다. 용어 "생산량" 및 "생산성"은 당업계에 공지되어 있으며 소정의 기간 및 소정의 발효 부피에서 생산될 발효 생성물 (예컨대 관심 정밀 화학물질)의 농도 (예컨대 1 L 당 생성물 질량 (kg)/시간)를 포함한다. 용어 "생산 효율"은 특정 생산량 (예를 들어, 세포에 의한 정밀 화학물질의 처리량이 특정 속도에 도달하는데 필요한 시간) 달성에 필요한 시간을 포함한다. 용어 "수율" 또는 "생성물/탄소 수율"은 당업계에 공지되어 있으며 탄소 공급원을 생성물 (즉, 정밀 화학물질)로 전환시키는 효율을 포함한다. 즉, 이는 예를 들어 통상적으로 탄소 공급원 1 kg 당 생성물의 질량 (kg)으로 표현된다. 화합물의 수율 또는 생산 증가는 특정량의 배양물에서 소정의 시간에 걸쳐 수득되는 상기 분자의 양 또는 이 화합물의 적합하게 수득되는 분자의 양을 증가시킨다. 용어 "생합성" 및 "생합성 경로"는 당업계에 공지되어 있으며 세포가 중간체로부터 화합물, 바람직하게는 유기 화합물을 예를 들어 다단계 과정 또는 고도로 조절되는 과정을 통해 합성하는 것을 포함한다. 용어 "분해" 및 "분해 경로"는 당업계에 공지되어 있으며 세포가 화합물, 바람직하게는 유기 화합물을 예를 들어 다단계 과정 또는 고도로 조절되는 과정을 통해 분해 생성물 (더욱 일반적인 용어로는, 더 작거나 덜 복잡한 분자)로 절단하는 것을 포함한다. 용어 "대사"는 당업계에 공지되어 있으며 유기체에서 일어나는 전반적인 생화학적 반응을 포함한다. 이때, 특정 화합물의 대사 (예컨대 글리신 등과 같은 아미노산의 대사)는 그 화합물과 관련된 세포내 모든 생합성, 변형 및 분해 경로를 포함한다.
또다른 실시양태에서, 본 발명의 MCP 분자는 미생물, 예를 들어 코리네박테리움 글루타미쿰 내에서 관심 분자, 예를 들어 정밀 화학물질의 생산을 직접 또는 간접적으로 조정할 수 있다. 유전자 재조합 기술을 이용하여 본 발명의 1종 이상의 MCP 단백질을 조작함으로써 이들의 기능을 조정할 수 있다. 이러한 기능 조정을 통해 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정할 수 있다.
예를 들면, 정밀 화학물질의 생합성 또는 분해에 관여하는 단백질의 활성을 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)시켜 세포에 의한 상기 화합물의 합성능 또는 분해능을 직접 조정함으로써, 정밀 화학물질의 수율 및(또는) 생산 효율을 조정할 수 있다. 또한, 정밀 화학물질의 대사 경로를 조절하는 단백질의 활성을 조정하여 원하는 화합물의 생산이 상향 또는 하향 조절되도록 함으로써 두 경우 모두에서 세포로부터의 정밀 화학물질 수율 또는 생산 효율이 조정되도록 직접적인 영향을 미칠 수 있다.
정밀 화학물질 생산의 간접 조정은 본 발명에 따른 단백질의 활성 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)에 의해 수행되어, 세포의 성장력 및 분열력 또는 살아있는 상태로의 유지력 또는 생산성 유지력을 전반적으로 증가시킬수도 있다. 통상적으로, 코리네박테리움 글루타미쿰으로부터의 정밀 화학물질 생산은 상기 미생물을 종종 세포 성장 및 세포 분열에 최적인 상태에 준하는 조건하에 대량으로 발효 배양함으로써 수행된다. 본 발명의 단백질 (예를 들어 스트레스 반응 단백질, 세포벽 단백질 또는 뉴클레오티드 및 아미노산 등과 같이 세포 분열 및 세포 성장 수행에 필요한 화합물의 대사에 관여하는 단백질)을 변형시켜 상기 조건하에서의 생존, 성장 및 전파를 개선시킴으로써, 상기 변형된 코리네박테리움 글루타미쿰 세포의 대량 배양시 수 및 생산성이 증가되도록 할 수 있는데, 이는 1종 이상의 원하는 정밀 화학물질의 수율 및(또는) 생산 효율을 증가시키는 것이다. 추가로, 세포의 대사 경로는 반드시 상호 의존적이고 동시 조절되는 것이다. 코리네박테리움 글루타미쿰의 임의의 대사 경로에서의 활성을 변화시킴 (즉, 그러한 경로에 관여하는 본 발명의 단백질들 중 하나의 활성을 변화시킴)으로써 상기 미생물에서 정밀 화학물질의 합성 또는 분해에 직접적으로 관여할 수 있는 또다른 대사 경로의 활성 또는 그에 대한 조절을 동시에 변화시킬 수 있다.
본 발명의 단리된 핵산 서열은 아메리칸 타입 컬쳐 콜렉션 (American Type Culture Collection)에서 ATCC 13032로 입수할 수 있는 코리네박테리움 글루타미쿰 균주의 게놈에 위치한다. 단리된 코리네박테리움 글루타미쿰 MCP 핵산 분자의 뉴클레오티드 서열 및 코리네박테리움 글루타미쿰 MCP 단백질의 예측되는 아미노산 서열을 첨부문서 A 및 첨부문서 B에 각각 나타내었다. 컴퓨터 분석을 수행하여 이러한 뉴클레오티드 서열 중에서 대장균 (E. coli) 또는 바실러스 섭틸리스 (Bacillussubtilis) 유전자와 상동성이 있는 많은 서열들을 분류 및(또는) 확인하였다.
또한, 본 아미노산 서열이 첨부문서 B의 아미노산 서열에 본질적으로 상동성이 있는 단백질에 관한 것이다. 본원에서 사용된 바와 같이, 아미노산 서열이 선택된 아미노산 서열에 본질적으로 상동성이 있는 단백질은 상기 선택된 아미노산 서열, 예를 들어 선택된 아미노산 서열 전체에 대한 상동성이 약 50％ 이상이다. 아미노산 서열이 선택된 아미노산 서열에 본질적으로 상동성이 있는 단백질은 상기 선택된 아미노산 서열에 대한 상동성이 약 50 내지 60％ 이상, 바람직하게는 약 60 내지 70％ 이상, 더욱 바람직하게는 약 70 내지 80％ 이상, 약 80 내지 90％ 이상 또는 약 90 내지 95％ 이상일 수도 있고, 가장 바람직하게는 약 96％ 이상, 약 97％ 이상, 약 98％ 이상, 약 99％ 이상이거나 심지어는 그 이상일 수도 있다.
본 발명의 MCP 단백질 또는 그의 생물학적 활성 절편 또는 단편은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 탄화수소를 분해하거나 테르페노이드를 산화시키거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 약물 개발을 위한 표적으로 작용하거나 그에 대한 확인용 마커로 작용할 수 있다.
하기 단락에서는 본 발명의 여러가지 측면을 더욱 상세하게 기재한다:
A. 단리된 핵산 분자
본 발명의 한 측면은 MCP 분자를 코딩하는 단리된 핵산 분자 또는 그의 생물학적 활성 절편에 관한 것이며, 또한 MCP-코딩 핵산 (예컨대 MCP DNA)의 확인 또는 증폭을 위한 혼성화 프로브 또는 프라이머로 사용하기에 충분한 핵산 단편에 관한것이다. 이러한 핵산 분자는 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체의 확인, 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체 게놈의 맵핑 또는 발효 공정 등을 통해 정밀 화학물질의 생산에 적합한 미생물의 확인에 이용될 수 있다. 본원에서 사용된 바와 같이, 용어 "핵산 분자"는 DNA 분자 (예컨대 cDNA 또는 게놈 DNA) 및 RNA 분자 (예컨대 mRNA)를 포함하며, 또한 뉴클레오티드 유사체에 의해 생성된 DNA 또는 RNA 유사체를 포함한다.
추가로, 상기 용어는 코딩 유전자 영역의 3' 및 5' 말단에 위치한 비번역 서열 (코딩 영역의 5' 말단 상류 서열의 뉴클레오티드 약 100개 이상 및 코딩 유전자 영역의 3' 말단 하류 서열의 뉴클레오티드 약 20개 이상)을 포함한다. 핵산 분자는 단일 가닥일 수도 있고 이중 가닥일 수도 있으나, 바람직하게는 이중 가닥 DNA이다. "단리된" 핵산 분자는 해당 핵산의 천연 공급원에 존재하는 다른 핵산 분자가 제거된 것이다. "단리된" 핵산은 해당 핵산이 기원된 유기체의 게놈 DNA의 핵산을 천연적으로 플랭킹 (flanking)하는 임의의 서열 (예를 들어 해당 핵산의 5' 또는 3' 말단에 위치한 서열)을 보유하지 않는 것이 바람직하다. 여러 실시양태에서, 단리된 MCP 핵산 분자는 해당 핵산이 기원된 세포 (예컨대 코리네박테리움 글루타미쿰 세포)의 게놈 DNA의 핵산 분자를 천연적으로 플랭킹하는 뉴클레오티드 서열을 예를 들어 약 5 kb 미만, 약 4 kb 미만, 약 3 kb 미만, 약 2 kb 미만, 약 1 kb 미만, 약 0.5 kb 미만 또는 약 0.1 kb 미만으로 보유할 수 있다. 게다가, cDNA 분자 등과 같은 "단리된" 핵산 분자에는, 재조합 기술로 제조된 경우에는 다른 세포내 물질 또는 배양 배지가 본질적으로 존재하지 않으며 화학적으로 합성된경우에는 화학적 전구체 또는 다른 화학물질이 본질적으로 존재하지 않을 수 있다.
본 발명의 핵산 분자, 예를 들어 첨부문서 A의 뉴클레오티드 서열 또는 그의 절편을 보유하는 핵산 분자는 분자생물학 표준 기술 및 본원에 제공된 서열 정보를 통해 단리할 수 있다. 예를 들면, 코리네박테리움 글루타미쿰 MCP cDNA는 첨부문서 A로부터의 완전 서열 또는 그의 절편을 혼성화 프로브로서 이용하고 표준 혼성화 기술 (예를 들어 문헌 [Sambrook, J., Fritsch, E.F. and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]에 기재된 바와 같음)을 이용하여 코리네박테리움 글루타미쿰 뱅크 (bank)에서 단리할 수 있다. 추가로, 첨부문서 A로부터의 완전 서열 또는 그의 절편을 포함하는 핵산 분자는 상기 서열을 기초로 생성한 올리고뉴클레오티드 프라이머를 사용하는 폴리머라제 연쇄 반응으로 단리할 수 있다 (예를 들어, 첨부문서 A로부터의 완전 서열 또는 그의 절편을 포함하는 핵산 분자는 첨부문서 A로부터의 동일 서열을 기초로 생성한 올리고뉴클레오티드 프라이머를 사용한 폴리머라제 연쇄 반응으로 단리할 수 있음). 예를 들면, mRNA는 정상적인 내피 세포에서 단리할 수 있고 (예를 들어 문헌 [Chirgwin et al. (1979) Biochemistry 18:5294-5299]의 구아니디늄-티오시아네이트 추출 방법에 의한 단리), cDNA는 역전사효소 (예를 들어 미국 메릴랜드주 베테스다에 소재하는 Gibco/BRL이 시판하는 몰로니 (Moloney)-MLV 역전사효소 또는 미국 플로리다주 세인트 페터스부르크에 소재하는 세이카가꾸 아메리카, 인크. (Seikagaku America, Inc.)에서 구입한 AMV 역전사효소) 및 첨부문서 A에 나타낸 임의의 뉴클레오티드 서열을 기초로 하는 무작위 폴리뉴클레오티드 프라이머 또는 올리고뉴클레오티드 프라이머를 사용하여 제조할 수 있다. 폴리머라제 연쇄 반응을 통한 증폭에 사용하기 위한 합성 올리고뉴클레오티드 프라이머는 첨부문서 A에 나타낸 임의의 뉴클레오티드 서열을 기초로 생성할 수 있다. 본 발명의 핵산은 cDNA로 증폭시킬 수도 있고, 별법으로는 주형으로서의 게놈 DNA 및 PCR 표준 증폭 기술에 따른 적합한 올리고뉴클레오티드 프라이머를 사용하여 증폭시킬 수도 있다. 이러한 방법으로 증폭된 핵산을 적합한 벡터에 클로닝하고 DNA 서열 분석함으로써 특징규명할 수 있다. 또한, MCP 뉴클레오티드 서열에 상응하는 올리고뉴클레오티드는 자동 DNA 합성기 등과 같은 표준 합성법을 통해 제조할 수도 있다.
바람직한 실시양태에서, 본 발명의 단리된 핵산 분자는 첨부문서 A에 기재한 임의의 뉴클레오티드 서열을 포함한다. 첨부문서 A의 서열은 코리네박테리움 글루타미쿰으로부터의 본 발명의 MCP cDNA에 상응한다. 이러한 cDNA는 MCP 단백질에 대한 서열 (즉, 첨부문서 A의 각 서열에 나타낸 "코딩 영역") 및 또한 첨부문서 A에 나타낸 5' 및 3' 비번역 서열을 포함한다. 별법으로, 상기 핵산 분자는 첨부문서 A에 나타낸 임의의 서열의 코딩 영역만을 포함할 수 있다.
게다가, 본 발명의 핵산 분자는 첨부문서 A에 나타낸 임의의 서열의 코딩 영역의 절편 하나만을 포함할 수 있으며, 예를 들어 상기 단편은 프로브 또는 프라이머로서 사용될 수도 있고 MCP 단백질의 생물학적 활성 절편을 코딩하는 단편일 수도 있다. 코리네박테리움 글루타미쿰 MCP 유전자를 클로닝하여 결정된 뉴클레오티드 서열을 이용하면, 다른 유형의 세포 및 유기체에서의 MCP 상동체 및 다른 코리네박테리움 또는 그와 관련된 종에서 MCP 상동체를 확인하고(하거나) 클로닝하도록 고안된 프로브 및 프라이머를 생성할 수 있다. 일반적으로, 상기 프로브 또는 프라이머는 본질적으로 정제된 올리고뉴클레오티드를 포함한다. 일반적으로, 상기 올리고뉴클레오티드는 첨부문서 A에 나타낸 임의의 서열의 센스 가닥, 첨부문서 A에 나타낸 임의의 서열의 안티센스 가닥 또는 이들의 천연 돌연변이체의 연속적인 뉴클레오티드 약 12개 이상, 바람직하게는 약 25개 이상, 더욱 바람직하게는 약 40개 이상, 약 50개 이상 또는 약 75개 이상과 엄격 조건하에서 혼성화하는 뉴클레오티드 서열 영역을 포함한다. 첨부문서 A의 뉴클레오티드 서열을 기초로 하는 프라이머는 MCP 상동체를 클로닝하기 위한 PCR 반응에 사용할 수 있다. MCP 뉴클레오티드 서열을 기초로 하는 프로브는 동일 단백질 또는 상동성 단백질을 코딩하는 전사체 또는 게놈 서열의 검출에 사용할 수 있다. 바람직한 실시양태에서, 상기 프로브는 그에 결합하는 표지기, 예를 들어 방사성동위원소, 형광 화합물, 효소 또는 효소 보조인자를 추가로 포함한다. 이러한 프로브는 예를 들어 MCP mRNA 수준을 검출하여 세포 샘플 중에 존재하는 MCP-코딩 핵산을 정량하거나 게놈 MCP 유전자가 돌연변이되거나 결실되었는지 여부를 결정함으로써 MCP 단백질의 발현에 결점이 있는 세포를 확인하는 진단용 분석 키트의 일부로서 사용될 수 있다.
한 실시양태에서, 본 발명의 핵산 분자는 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 탄화수소를 분해하거나 테르페노이드를 산화시키거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 약물 개발을 위한 표적으로 작용하거나 그에 대한 확인용마커로 작용할 수 있는 능력을 보유하는, 첨부문서 B의 아미노산 서열에 충분한 상동성이 있는 아미노산 서열을 포함하는 단백질 또는 그의 절편을 코딩한다. 본원에서 사용된 바와 같이, 용어 "충분한 상동성이 있는"은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 탄화수소를 분해하거나 테르페노이드를 산화시키거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 약물 개발을 위한 표적으로 작용하거나 그에 대한 확인용 마커로 작용할 수 있는, 아미노산 서열이 첨부문서 B의 아미노산 서열과 동일한 아미노산 잔기 또는 그와 동등한 아미노산 잔기 (예를 들어 첨부문서 B에 나타낸 임의의 서열의 아미노산 잔기의 측쇄와 유사한 측쇄를 갖는 아미노산 잔기)를 최소수로 보유하는 단백질 또는 그의 절편과 관련된 것이다. 이러한 활성의 예는 본원에 기재한 바와 같다. 따라서, "MCP 단백질의 기능"은 1종 이상의 정밀 화학물질의 대사 경로에 대한 전반적 조절 또는 탄화수소의 분해 또는 테르페노이드의 산화에 기여한다.
본 발명의 MCP 핵산 분자가 코딩하는 단백질의 절편은 임의의 MCP 단백질의 생물학적 활성 절편인 것이 바람직하다. 본원에서 사용된 바와 같이, 용어 "MCP 단백질의 생물학적 활성 절편"은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하고 탄화수소를 분해하고 테르페노이드를 산화시키며 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 약물 개발을 위한 표적 단백질로 작용하거나 그에 대한 확인용 마커로 작용하는 MCP 단백질의 절편, 예를 들어 도메인 또는 모티프를 포함한다. MCP 단백질 또는 그의 생물학적 활성 절편이 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및 생산 효율을 조정하거나 탄화수소를 분해하거나 테르페노이드를 산화시킬 수 있는 지의 여부는 효소 활성 분석을 수행하여 결정할 수 있다. 이러한 분석 방법은 실시예 단락의 실시예 8에 상세하게 기재한 바와 같이 당업자에게 공지되어 있다.
MCP 단백질의 생물학적 활성 절편을 코딩하는 추가의 핵산 단편은, 첨부문서 B에 나타낸 임의의 서열의 절편을 단리하고 MCP 단백질 또는 MCP 펩티드의 코딩된 절편을 발현 (예를 들어 시험관내 재조합 발현에 의함)하고 MCP 단백질 또는 MCP 펩티드의 코딩된 절편의 활성을 측정하여 제조할 수 있다.
추가로, 본 발명은 첨부문서 A에 나타낸 임의의 뉴클레오티드 서열 (및 그의 절편)과는 상이하지만, 유전자 코드의 동의성 (degeneracy)으로 인해 첨부문서 A에 나타낸 뉴클레오티드 서열에 의해 코딩되는 것과 동일한 MCP 단백질을 코딩하는 핵산 분자를 포함한다. 또다른 실시양태에서, 본 발명의 단리된 핵산 분자는 첨부문서 B에 나타낸 아미노산 서열의 단백질을 코딩하는 뉴클레오티드 서열을 보유한다. 추가의 실시양태에서, 본 발명의 핵산 분자는 첨부문서 B의 아미노산 서열 (첨부문서 A에 나타낸 오픈 리딩 프레임에 의해 코딩됨)에 본질적으로 상동성이 있는 전장 코리네박테리움 글루타미쿰 단백질을 코딩한다.
또한, 당업자는 집단 내에 존재할 수 있는 천연 MCP-서열 변이체 뿐 아니라 첨부문서 A의 뉴클레오티드 서열에 돌연변이에 의한 변화가 도입되어, 코딩된 MCP 단백질의 아미노산 서열을 변화시키면서도 MCP 단백질의 기능을 손상시키지 않을수 있음을 이해할 것이다. 따라서, 예를 들어 첨부문서 A의 서열에서 "비필수" 아미노산 잔기에서의 아미노산 치환을 일으키는 뉴클레오티드 치환을 생성할 수 있다. "비필수" 아미노산 잔기는 임의의 MCP 단백질의 야생형 서열 (첨부문서 B)을 변경시키면서도 상기 MCP 단백질의 활성을 변화시키지 않을 수 있는 잔기이며, "필수" 아미노산 잔기는 MCP 단백질 활성에 필요한 잔기이다. 그러나, 다른 아미노산 잔기 (예컨대 MCP 활성을 갖는 도메인에서 비-보존 또는 단지 반-보존된 아미노산 잔기)가 활성에 비필수일 수도 있기 때문에 이를 변형시키면서 MCP 활성은 변형시키지 않을 수도 있을 것이다.
따라서, 본 발명의 또다른 측면은 MCP 활성에 비필수인 아미노산 잔기에서의 변형을 함유하는 MCP 단백질을 코딩하는 핵산 분자에 관한 것이다. 이러한 MCP 단백질의 아미노산 서열은 첨부문서 B의 서열과 상이하지만, 상기 단백질은 본원에 기재한 MCP 활성을 하나 이상 보유한다. 한 실시양태에서, 상기 단리된 핵산 분자는 첨부문서 B의 아미노산 서열에 약 50％ 이상의 상동성이 있으며 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 탄화수소를 분해하거나 테르페노이드를 산화시키거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 약물 개발을 위한 표적으로 작용하거나 그에 대한 확인용 마커로 작용할 수 있는 아미노산 서열을 포함하는 단백질을 코딩하는 뉴클레오티드 서열을 포함한다.
첨부문서 B의 단백질 서열에 상동성이 있는 MCP 단백질을 코딩하는 단리된 핵산 분자는 첨부문서 A의 뉴클레오티드 서열에 하나 이상의 뉴클레오티드 치환,부가 또는 결실을 도입하여 생성할 수 있으며, 이에 의해 코딩된 단백질에는 하나 이상의 아미노산 치환, 부가 또는 결실이 도입된다. 상기 돌연변이는 부위-지정 돌연변이유발법 및 PCR-매개 돌연변이유발법 등과 같은 표준 기술을 통해 첨부문서 A에 나타낸 임의의 서열에 도입될 수 있다. 비필수라고 예측되는 하나 이상의 아미노산 잔기에 보존적 아미노산 치환을 도입하는 것이 바람직하다. "보존적 아미노산 치환"은 해당 아미노산 잔기를 유사한 측쇄를 갖는 아미노산 잔기로 대체한다. 유사한 측쇄를 갖는 아미노산 잔기의 군은 당업계에 규정되어 있다. 이들 군은 염기성 측쇄를 갖는 아미노산 (예컨대 리신, 아르기닌, 히스티딘), 산성 측쇄를 갖는 아미노산 (예컨대 아스파르트산, 글루탐산), 대전되지 않은 극성 측쇄를 갖는 아미노산 (예컨대 글리신, 아스파라긴, 글루타민, 세린, 트레오닌, 티로신, 시스테인), 비극성 측쇄를 갖는 아미노산 (예컨대 알라닌, 발린, 루이신, 이소루이신, 프롤린, 페닐알라닌, 메티오닌, 트립토판), 베타-분지된 측쇄를 갖는 아미노산 (예컨대 트레오닌, 발린, 이소루이신) 및 방향족 측쇄를 갖는 아미노산 (예컨대 티로신, 페닐알라닌, 트립토판, 히스티딘)을 포함한다. 따라서, MCP 단백질에서 비필수라고 예측되는 아미노산 잔기는 동일 측쇄군의 또다른 아미노산 잔기로 대체되는 것이 바람직하다. 별법으로, 또다른 실시양태에서는 상기 돌연변이를 MCP-코딩 서열 전체 또는 일부에 예를 들어 포화 돌연변이유발법 등을 통해 무작위로 도입할 수 있고, 생성되는 돌연변이체를 본원에 기재한 MCP 활성에 대해 시험하여 MCP 활성을 유지하는 돌연변이체를 확인할 수 있다. 첨부문서 A에 나타낸 임의의 서열을 돌연변이유발시킨 후에, 코딩되는 단백질을 재조합으로 발현시킬 수 있고, 상기 단백질의 활성을 예를 들어 본원에 기재한 분석법을 이용하여 측정할 수 있다 (실시예 단락의 실시예 8 참조).
B. 재조합 발현 벡터 및 숙주 세포
본 발명의 또다른 측면은 MCP 단백질 (또는 그의 절편)을 코딩하는 핵산을 함유하는 벡터, 바람직하게는 발현 벡터에 관한 것이다. 본원에서 사용된 바와 같이, 용어 "벡터"는 그와 결합된 또다른 핵산을 수송할 수 있는 핵산 분자와 관련된 것이다. 벡터의 유형 중 하나는 추가의 DNA 세그먼트가 라이게이션될 수 있는 원형 이중 가닥 DNA 루프를 의미하는 용어인 "플라스미드"이다. 또다른 유형의 벡터는 바이러스 벡터이며, 여기서는 추가의 DNA 세그먼트를 바이러스 게놈에 라이게이션시킬 수 있다. 몇몇 벡터들은 그들이 도입된 숙주 세포 내에서 자율적으로 복제될 수 있다 (예를 들어, 박테리아 복제 기점을 갖는 박테리아 벡터 및 에피솜 포유동물 벡터). 다른 벡터들 (예컨대 비-에피솜 포유동물 벡터)은 숙주 세포에 도입될 때 상기 숙주 세포의 게놈에 통합됨으로써 숙주 게놈과 함게 복제된다. 추가로, 몇몇 벡터들은 기능적으로 연결된 유전자의 발현을 제어할 수 있다. 본원에서는 이러한 벡터를 "발현 벡터"라고 지칭한다. 통상, DNA 재조합 기술에 사용되는 발현 벡터는 플라스미드 형태이다. 플라스미드가 가장 일반적으로 사용되는 유형의 벡터이므로, 본 명세서에서는 "플라스미드" 및 "벡터"를 혼용하여 사용한다. 그러나, 본 발명은 유사한 기능을 발휘하는 다른 유형의 발현 벡터, 예를 들어 바이러스 벡터 (예컨대 복제-결핍 레트로바이러스, 아데노바이러스 및 아데노바이러스-관련 바이러스)를 포함한다.
본 발명의 재조합 발현 벡터는 본 발명의 핵산을 숙주 세포에서의 발현에 적합한 형태로 포함하며, 이는 재조합 발현 벡터가 발현에 사용될 숙주 세포를 기초로 하여 선택되고 발현될 핵산 서열에 기능적으로 연결된 하나 이상의 조절 서열을 포함함을 의미한다. 재조합 발현 벡터에서, 용어 "기능적으로 연결된"은 관심 뉴클레오티드 서열이 그의 발현 (예를 들어 시험관내 전사/번역 시스템에서 발현되거나 또는 상기 벡터가 숙주 세포에 도입된 경우에는 그 숙주 세포에서 발현됨)이 가능하도록 조절 서열(들)에 결합된 것을 의미한다. 용어 "조절 서열"은 프로모터, 레프레서-결합 부위, 활성자-결합 부위, 인핸서 영역 및 다른 발현 제어 요소 (예컨대 종결자, mRNA 2차 구조의 다른 요소 또는 폴리아데닐화 신호)를 포함한다. 이러한 조절 서열에 대해서는 예를 들어 문헌 [Goeddel: Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990)] 등에 기재되어 있다. 조절 서열은 여러 유형의 숙주 세포에서 뉴클레오티드 서열의 구성적 (constitutive) 발현을 제어하는 서열 및 특정 숙주 세포에서만 뉴클레오티드 서열의 발현을 제어하는 서열을 포함한다. 당업자라면, 발현 벡터의 고안이 형질전환시킬 숙주 세포의 선택, 원하는 단백질 발현 정도 등과 같은 인자에 따라 달라질 수 있음을 이해할 것이다. 본 발명의 발현 벡터를 숙주 세포에 도입함으로써, 본원에 기재한 바와 같은 핵산에 의해 코딩되는 융합 단백질 또는 융합 펩티드 (예컨대 MCP 단백질, MCP 단백질의 돌연변이된 형태, 융합 단백질 등)를 비롯한 단백질 또는 펩티드를 제조할 수 있다.
본 발명의 재조합 발현 벡터는 원핵 세포 또는 진핵 세포에서 MCP 단백질을발현하도록 고안될 수 있다. 예를 들면, MCP 유전자는 박테리아 세포, 예를 들어 코리네박테리움 글루타미쿰, 곤충 세포 (이 경우에는 바큘로바이러스 발현 벡터를 사용함), 효모 세포 및 기타 진균 세포 (문헌 [Romanos, M.A. et al. (1992) "Foreign gene expression in yeast: a review" Yeast 8: 423-488], [van den Hondel, C.A.M.J.J. et al. (1991) "Heterologous gene expression in filamentous fungi" in: More Gene Manipulations in Fungi, J.W. Bennet ＆ L.L. Lasure, Editors, pp. 396-428: Academic Press: San Diego] 및 [van den Hondel, C.A.M.J.J. ＆ Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi" in: Applied Molecular Genetics of Fungi, Peberdy, J.F. et al., Editors, pp. 1-28, Cambridge University Press: Cambridge] 참조), 조류(藻類) 및 다세포 식물 세포 (문헌 [Schmidt, R. and Willmitzer, L. (1988) "High efficiency Agrobacterium tumefaciens-mediated transformation of Arabidopsis thaliana leaf and cotyledon explants", Plant Cell Rep.: 583-586] 참조) 또는 포유동물 세포에서 발현될 수 있다. 적합한 숙주 세포는 문헌 [Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990)]에 추가로 논의되어 있다. 별법으로, 재조합 발현 벡터는 예를 들어 T7 프로모터 조절 서열 및 T7 폴리머라제를 사용하여 시험관내 전사 및 번역시킬 수 있다.
단백질은 융합 또는 비-융합 단백질의 발현을 제어하는 구성적 또는 유도가능한 프로모터를 함유하는 벡터를 주로 사용하여 원핵생물에서 발현시킨다. 융합벡터는 그에 의해 코딩되는 단백질에, 통상적으로는 재조합 단백질의 아미노 말단에 수많은 아미노산을 부가한다. 이러한 융합 벡터는 통상적으로 다음의 3가지 기능을 수행한다: 1) 재조합 단백질의 발현을 증진시킴; 2) 재조합 단백질의 가용성을 증가시킴; 3) 친화성 정제시에 리간드로서 작용하여 재조합 단백질의 정제를 보조함. 종종, 융합 발현 벡터에서 융합 단위와 재조합 단백질의 접합부에 단백질분해성 절단 부위를 도입함으로써, 재조합 단백질이 융합 단백질의 정제 후에 상기 융합 단위로부터 분리될 수 있도록 한다. 이러한 효소 및 이들의 상응하는 인식 서열은 인자 Xa, 트롬빈 및 엔테로키나제를 포함한다.
통상의 융합 발현 벡터는 재조합 표적 단백질에 글루타티온 S-트랜스퍼라제 (GST)가 융합된 pGEX (파마시아 바이오테크 인크. (Pharmacia Biotech Inc.) 제품, [Smith, D.B. and Johnson, K.S. (1988) Gene 67:31-40]), 재조합 표적 단백질에 말토스 E-결합 단백질이 융합된 pMAL (미국 매사추세츠주 배벌리에 소재하는 뉴 잉글랜드 바이오랩스 (New England Biolabs) 제품) 및 재조합 표적 단백질에 단백질 A가 융합된 pRIT 5 (미국 뉴저지주 피스카타웨이에 소재하는 파마시아 제품)를 포함한다. 한 실시양태에서, MCP 단백질-코딩 서열을 pGEX 발현 벡터에 클로닝하여, 상기 벡터가 N-말단에서 C-말단 방향으로 GST-트롬빈 절단 부위-단백질 X를 포함하는 융합 단백질을 코딩하도록 한다. 융합 단백질은 글루타티온-아가로스 수지를 사용한 친화성 크로마토그래피로 정제할 수 있다. GST에 융합되지 않은 재조합 MCP 단백질은 융합 단백질을 트롬빈으로 절단하여 수득할 수 있다.
적합한 유도가능한 비-융합 대장균 발현 벡터의 예로는 pTrc [Amann et al.,(1988) Gene 69:301-315] 및 pET 11d [Studier et al. Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89] 등이 있다. pTrc 벡터로부터의 표적-유전자 발현은 숙주 RNA 폴리머라제에 의한 하이브리드 trp-lac 융합 프로모터로부터의 전사를 기초로 한다. pET 11d 벡터로부터의 표적-유전자 발현은 동시발현되는 바이러스 RNA 폴리머라제 (T7 gn1)에 의해 매개되는 T7-gn10-lac 융합 프로모터로부터의 전사를 기초로 한다. BL21 (DE3) 또는 HMS174 (DE3) 숙주 균주에서, 상기 바이러스 폴리머라제는 lacUV 5 프로모터의 전사 제어를 받는 T7 gn1 유전자를 보유하는 상재 (resident) λ 프로파지에 의해 제공된다.
재조합 단백질의 발현을 최대화하기 위한 전략 중 하나는 상기 재조합 단백질을 그에 대한 단백질분해성 절단력이 파괴된 숙주 박테리아에서 발현시키는 것이다 [Gottesman, S. Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128]. 또다른 전략은 발현 벡터로 삽입될 핵산의 핵산 서열을 변형시켜 각 아미노산에 대한 개개의 코돈이 발현을 위해 선택한 박테리아, 예를 들어 코리네박테리움 글루타미쿰에서 바람직하게 이용되는 코돈이 되도록 하는 것이다 [Wada et al. (1992) Nucleic Acids Res. 20:2111-2118]. 본 발명의 핵산 서열에 대한 이러한 변형은 DNA 합성의 표준 기술을 이용하여 수행할 수 있다.
추가의 실시양태에서, MCP 단백질 발현 벡터는 효모 발현 벡터이다. 효모 사카로마이세스 세레비지애 (Saccharomyces cerevisiae)에서 발현시키기 위한 벡터의 예로는 pYepSec1 [Baldari et al., (1987) Embo J. 6:229-234], pMFa [Kurjan and Herskowitz (1982) Cell 30:933-943], pJRY88 [Schultz et al. (1987) Gene 54:113-123] 및 pYES2 (미국 캘리포니아주 샌 디에고에 소재하는 인비트로젠 코포레이션 (Invitrogen Corporation) 제품) 등이 있다. 다른 진균, 예를 들어 섬유상 진균에 사용하기에 적합한 벡터 및 그의 제작 방법은 문헌 [van den Hondel, C.A.M.J.J. ＆ Punt, P.J. (1991) "Gene Transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J.F. Peberdy et al., Editors, pp. 1-28, Cambridge University Press: Cambridge]에 상세하게 기재된 것들을 포함한다.
별법으로, 본 발명의 MCP 단백질은 바큘로바이러스 발현 벡터를 사용한 곤충 세포에서 발현될 수도 있다. 배양된 곤충 세포 (예컨대 Sf9 세포)에서의 단백질 발현에 이용가능한 바큘로바이러스 벡터로는 pAc 계열 [Smith et al., (1983) Mol. Cell Biol. 3:2156-2165] 및 pVL 계열 [Lucklow and Summers (1989) Virology 170:31-39] 등이 있다.
추가의 실시양태에서, 본 발명의 MCP 단백질은 단세포 식물 세포 (예컨대 조류) 또는 고등 식물 (예컨대 작물 등의 종자식물) 세포에서 발현될 수 있다. 식물 발현 벡터의 예로는 문헌 ([Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border", Plant Mol. Biol. 20:1195-1197] 및 [Bevan, M.W. (1984) "Binary Agrobacterium vectors for plant transformation", Nucl. Acids Res.12:8711-8721])에 상세하게 기재된 것들을 포함한다.
또다른 실시양태에서, 본 발명의 핵산 발현을 포유동물 발현 벡터를 사용한 포유동물 세포에서 수행한다. 포유동물 발현 벡터의 예로는 pCDM8 [Seed, B. (1987) Nature 329:840] 및 pMT2PC [Kaufman et al. (1987) EMBO J. 6:187-195] 등이 있다. 포유동물 세포에서 사용할 경우, 발현 벡터의 제어 기능은 종종 바이러스 조절 요소에 의해 제공된다. 통상 사용되는 프로모터는 예를 들어 폴리오마, 아데노바이러스 2, 사이토메갈로바이러스 및 시미안 바이러스 40에서 유래된 것이다. 원핵 세포 및 진핵 세포에 적합한 다른 발현 시스템에 대해서는 문헌 [Sambrook, J., Fritsch, E.F. and Maniatis, T., Molecular Cloning: A Laboratory Manual, 2ndEdition, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]의 제16장 및 제17장에서 찾을 수 있다.
추가의 실시양태에서, 재조합 포유동물 발현 벡터는 바람직하게는 특정 세포 유형에서 핵산을 발현시킬 수 있다 (예를 들어, 조직-특이적 조절 요소를 사용하여 핵산을 발현시킴). 조직-특이적 조절 요소는 당업계에 공지되어 있다. 적합한 조직-특이적 프로모터의 예로는 알부민 프로모터 (간-특이적; [Pinkert et al. (1987) Genes De. 1:268-277]), 림프양-특이적 프로모터 [Calame and Eaton (1988) Adv. Immunol. 43:235-275], 특히 T-세포 수용체의 프로모터 [Winoto and Baltimore (1989) EMBO J. 8:729-733] 및 이뮤노글로불린의 프로모터 ([Banerji etal. (1983) Cell 33:729-740], [Queen and Baltimore (1983) Cell 33:741-748]), 뉴런-특이적 프로모터 (예컨대 신경필라멘트 프로모터; [Byrne and Ruddle (1989) PNAS 86:5473-5477]), 췌장-특이적 프로모터 [Edlund et al., (1985) Science 230:912-916] 및 유선(乳腺)-특이적 프로모터 (예컨대 유장(乳漿) (milk serum) 프로모터; 미국 특허 제4,873,316호 및 유럽 특허 출원 번호 제264,166호) 등이 있으나 이에 제한되지 않는다. 또한, 발생-조절되는 프로모터의 예로는 뮤린 (murine) hox 프로모터 [Kessel and Gruss (1990) Science 249:374-379] 및 α-태아단백질 프로모터 [Campes and Tilghman (1989) Genes Dev. 3:537-546] 등이 있다.
추가로, 본 발명은 발현 벡터에 안티센스 방향으로 클로닝된 본 발명의 DNA 분자를 포함하는 재조합 발현 벡터를 제공한다. 이는 DNA 분자가 조절 서열에 기능적으로 연결되어 MCP mRNA에 대해 안티센스인 RNA 분자가 발현 (DNA 분자의 전사를 통해 발현됨)될 수 있음을 의미한다. 안티센스 방향으로 클로닝된 핵산에 기능적으로 결합되고 다수의 세포 유형에서 안티센스 RNA 분자가 지속적으로 발현되도록 제어하는 조절 서열을 선택할 수 있으며, 예를 들어 안티센스 RNA가 구성적으로 조직-특이적 발현되거나 세포 유형-특이적 발현되도록 제어하는 바이러스 프로모터 및(또는) 인핸서 또는 조절 서열을 선택할 수 있다. 안티센스 발현 벡터는 재조합 플라스미드, 파지미드 또는 약독화 바이러스의 형태일 수 있으며, 이는 벡터가 도입된 세포 유형에 따라 활성이 결정되는 고도로 효과적인 조절 영역의 제어하에서 안티센스 핵산을 생산한다. 안티센스 유전자를 이용한 유전자 발현의 조절에 관해서는 문헌 [Weintraub, H. et al., Antisense-RNA as a molecular tool forgenetic analysis, Reviews - Trends in Genetics, Vol. 1(1) 1986]에 논의되어 있다.
본 발명의 또다른 측면은 본 발명의 재조합 발현 벡터가 도입된 숙주 세포에 관한 것이다. 본원에서는 용어 "숙주 세포" 및 "재조합 숙주 세포"를 혼용하여 사용한다. 사실상, 이러한 용어는 특정 표적 세포와만 관련된 것이 아니라 그 세포의 자손 또는 잠재적인 자손과도 관련된 것이다. 돌연변이 또는 환경적 요인으로 인해서 특정 변형이 세대에 걸쳐 연속적으로 나타날 수 있기 때문에, 이 자손이 모(母) 세포와 반드시 동일한 것은 아니지만, 본원에서 사용된 바와 같이 상기 용어의 범위에 포함되는 것은 마찬가지이다.
숙주 세포는 원핵 세포이거나 진핵 세포일 수 있다. 예를 들면, MCP 단백질은 박테리아 세포, 예를 들어 코리네박테리움 글루타미쿰, 곤충 세포, 효모 또는 포유동물 세포 (예컨대 차이니스 햄스터 난소 (CHO) 세포 또는 COS 세포)에서 발현될 수 있다. 다른 적합한 숙주 세포는 당업자에게 공지되어 있다. 코리네박테리움 글루타미쿰과 관련되어 있고 적합한 방식으로 본 발명의 핵산 분자 및 단백질 분자를 위한 숙주 세포로서 사용될 수 있는 미생물은 표 3에 기재되어 있다.
통상의 형질전환 또는 형질감염 방법을 이용하여 벡터 DNA를 원핵 세포 또는 진핵 세포에 도입할 수 있다. 본원에서 사용된 바와 같이, 용어 "형질전환" 및 "형질감염", "접합" 및 "형질도입"은 외래 핵산 (예컨대 DNA)을 숙주 세포에 도입하는 것과 관련하여 천연 수용법 (natural competence), 화학적 매개 전달법, 인산칼슘 또는 염화칼슘 동시침전법, DEAE-덱스트란-매개된 형질감염법, 리포펙션법(lipofection) 또는 전기천공법 등과 같이 당업계에 공지된 다수의 방법을 포함한다. 숙주 세포의 형질전환 또는 형질감염에 적합한 방법은 문헌 [Sambrook et al., Molecular Cloning: A Laboratory Manual. 2ndEdition, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989] 및 다른 실험 안내서에서 찾을 수 있다.
포유동물 세포의 안정한 형질감염의 경우, 사용된 발현 벡터 및 이용된 형질감염 기술에 따라 오직 적은 비율의 세포만이 외래 DNA를 그의 게놈에 통합시킬 수 있음이 공지되어 있다. 통상적으로, 이러한 통합체는 선별가능한 마커 (예컨대 항생제 내성 유전자)를 코딩하는 유전자를 관심 유전자와 함께 숙주 세포에 도입함으로써 확인 및 선별된다. 바람직한 선별가능한 마커로는 G418, 하이그로마이신 및 메토트렉세이트 등과 같은 약물에 내성을 부여하는 유전자 등이 있다. 선별가능한 마커를 코딩하는 핵산을 MCP 단백질을 코딩하는 벡터에 함께 함유시켜서 숙주 세포에 도입하거나, 상기 벡터와는 별개인 벡터를 통해 숙주 세포에 도입할 수 있다. 안정하게 형질감염되어 핵산이 도입된 세포는 예를 들어 약물 선별을 통해 확인할 수 있다 (예를 들어 선별가능한 마커가 통합된 세포는 생존하지만 다른 세포는 사멸함).
상동성 재조합된 미생물을 생성하기 위해서는, MCP 유전자에 결실, 부가 또는 치환을 도입하여 그를 변형시킨, 예를 들어 기능적으로 파괴시킨 하나 이상의 MCP-유전자 절편을 함유하는 벡터를 제조한다. 상기 MCP 유전자는 코리네박테리움글루타미쿰 MCP 유전자인 것이 바람직하지만, 그와 관련된 박테리아 또는 심지어는 포유동물, 효모 또는 곤충 공급원으로부터의 상동체를 사용할 수도 있다. 바람직한 실시양태에서, 벡터는 상동성 재조합이 내인성 MCP 유전자를 기능적으로 파괴 (즉, 유전자가 더이상 기능적 단백질을 코딩하지 않게됨; "녹아웃 (knockout) 벡터"라고 지칭하기도 함)하도록 고안될 수 있다. 별법으로, 벡터는 상동성 재조합 돌연변이체 등이 내인성 MCP 유전자를 변형시키지만 여전히 기능적 단백질을 코딩하도록 고안될 수 있다 (예를 들어, 상류에 위치한 조절 영역을 변형시킴으로써 내인성 MCP 단백질의 발현이 변형되도록 할 수 있음). 상동성 재조합 벡터 내에 존재하는 변형된 MCP-유전자 절편의 5' 및 3' 말단에는 MCP 유전자의 추가 핵산이 플랭킹되어 있는데, 이는 벡터가 운반하는 외인성 MCP 유전자와 미생물의 내인성 MCP 유전자 사이의 상동성 재조합을 가능케 한다. 추가의 플랭킹 MCP 핵산은 내인성 유전자와의 성공적인 상동성 재조합에 충분한 길이이다. 통상적으로, 벡터는 플랭킹 DNA를 1 kb 미만으로 함유한다 (5' 말단 및 3' 말단 모두에서) (상동성 재조합 벡터에 관해서는 예를 들어 문헌 [Thomas, K.R. and Capecchi, M.R. (1987) Cell 51:503]의 기재 참조). 벡터를 미생물에 도입 (예를 들어 전기천공법에 의한 도입)하고, 도입된 MCP 유전자가 내인성 MCP 유전자와 상동성 재조합된 세포를 당업계에 공지된 방법으로 선별한다.
또다른 실시양태에서, 도입된 유전자의 발현을 조절할 수 있는 것으로 선택한 시스템을 함유하는 재조합 미생물을 생산할 수 있다. 벡터로의 MCP 유전자 삽입은 상기 유전자가 lac 오페론의 제어를 받게 하기 때문에, 예를 들어 MCP-유전자발현이 IPTG의 존재하에서만 가능해 진다. 이러한 조절 시스템은 당업계에 공지되어 있다.
본 발명의 숙주 세포, 예를 들어 배양된 원핵 세포 또는 진핵 숙주 세포를 사용하여 MCP 단백질을 생산할 수 있다 (즉, 발현시킬 수 있음). 추가로, 본 발명은 본 발명의 숙주 세포를 이용한 MCP 단백질의 생산 방법을 제공한다. 한 실시양태에서, 상기 방법은 본 발명의 숙주 세포 (MCP 단백질을 코딩하는 재조합 발현 벡터가 도입되어 있거나 그의 게놈에 야생형 또는 변형된 MCP 단백질을 코딩하는 유전자가 도입되어 있음)를 적합한 배지 중에서 MCP 단백질이 생산될 때까지 배양하는 단계를 포함한다. 추가의 실시양태에서, 상기 방법은 상기 배지 또는 숙주 세포로부터 MCP 단백질을 단리하는 단계를 포함한다.
C. 본 발명의 용도 및 방법
본원에 기재한 핵산 분자, 단백질, 단백질 상동체, 융합 단백질, 프라이머, 벡터 및 숙주 세포는 하기한 방법 중 하나 이상에서 사용할 수 있다: 코리네박테리움 글루타미쿰 및 그와 관련된 유기체의 확인, 코리네박테리움 글루타미쿰과 관련이 있는 유기체의 게놈 맵핑, 코리네박테리움 글루타미쿰 관심 서열의 확인 및 위치분석, 진화 연구, 기능수행에 필요한 MCP 단백질 영역의 결정, MCP 단백질의 활성 조정; 하나 이상의 대사 경로의 활성 조정 및 관심 화합물, 예컨대 정밀 화학물질의 세포내 생산 조정. 본 발명의 MCP 핵산 분자에는 여러가지 용도가 있다. 첫째로, 이들은 코리네박테리움 글루타미쿰 또는 그와 밀접한 관련이 있는 유기체의 확인에 이용될 수 있다. 또한, 이들은 미생물들이 혼합된 집단 내에서 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체를 확인하는데 사용될 수 있다. 본 발명은 매우 다양한 코리네박테리움 글루타미쿰 유전자의 핵산 서열을 제공한다. 1종 미생물의 집단 또는 미생물들이 혼합된 집단의 배양물에서 추출한 게놈 DNA를 엄격 조건하에서 코리네박테리움 글루타미쿰에 고유한 유전자 영역을 포함하는 프로브로 프로빙 (probing)함으로써 상기 유기체의 존재 여부를 결정할 수 있다. 코리네박테리움 글루타미쿰 자체는 병원성이 아니지만, 코리네박테리움 디프테리애 등과 같은 병원성 종과 관련이 있다. 이러한 유기체의 검출은 실질적인 임상적 중요성을 갖는다.
당업계에 공지된 기술을 이용하여, 샘플에서 코리네박테리움 글루타미쿰을 검출할 수 있다. 특히, 먼저 샘플 중의 세포를 적합한 액체 또는 적합한 고체 배양 배지 중에서 배양하여, 배양물 중의 세포수를 증가시킬 수 있다. 이러한 세포를 용균시키고 그에 함유된 전체 DNA를 추출하고, 적절한 경우에는 이를 정제함으로써 이후의 분석을 방해할 수 있는 세포 잔해 및 핵산 분자를 제거한다. 본 발명의 MCP 핵산 분자에 특이적인 프라이머를 핵산 샘플과 함께 인큐베이션시켜 폴리머라제 연쇄 반응 또는 당업계에 공지된 유사한 기술을 수행 (핵산 서열 증폭에 통상적으로 이용되는 일반적인 방법을 검토하기 위해서는 물리스 (Mullis) 등의 미국 특허 제4,683,195호, 동 제4,965,188호 및 문헌 ([Innis, M.A., und Gelfand, D.H. (1989) PCR-Protocols, A guide to Methods], [Applications, Academic Press, pp. 3-12] 및 [(1988) Biotechnology 6:1197]) 및 국제 특허 출원 WO 89/01050 참조)하면, 상기 특정 MCP 핵산 서열이 증폭된다 (상기 핵산 서열이 샘플 중에 존재하는경우). 증폭시킬 특정 핵산 서열은 코리네박테리움 글루타미쿰 및 오직 몇가지의 밀접한 관련이 있는 박테리아의 게놈에만 한정적으로 존재하는가에 기초하여 선택한다. 원하는 증폭 생성물이 존재하는 것은 코리네박테리움 글루타미쿰 또는 코리네박테리움 글루타미쿰과 밀접한 관련이 있는 유기체가 존재함을 지시한다.
추가로, 본 발명의 핵산 및 단백질 분자는 게놈의 특정 영역에 대한 마커로 작용할 수 있다. 당업계에 공지된 기술을 이용하면, 코리네박테리움 글루타미쿰 게놈에서 본 발명의 MCP 핵산 분자가 존재하는 물리적 위치를 검출할 수 있고, 이를 이용하여 맵상에서 다른 핵산 분자 및 유전자의 위치를 더 쉽게 결정할 수 있다. 추가로, 본 발명의 핵산 분자는 관련 종의 서열에 충분한 상동성이 있을 수 있으며, 이 경우에도 이러한 핵산 분자를 이용하여 해당 박테리아 (예컨대 브레비박테리움 락토페르멘툼)의 게놈 맵을 제작할 수 있다.
본 발명의 핵산 및 단백질 분자는 게놈 맵핑 뿐 아니라 코리네박테리움 글루타미쿰 단백질의 기능 연구에도 적합하다. 특정 코리네박테리움 글루타미쿰 DNA-결합 단백질이 결합하는 게놈 영역은 예를 들어 코리네박테리움 글루타미쿰 게놈을 절단하고 그 단편들을 DNA-결합 단백질과 함께 인큐베이션 시켜서 확인할 수 있다. 상기 단백질과 결합하는 단편은 본 발명의 핵산 분자로 바람직하게는 쉽게 검출가능한 표지를 이용하여 추가로 프로빙될 수 있다. 이러한 핵산 분자와 게놈 단편의 결합을 통해, 코리네박테리움 글루타미쿰의 게놈 맵에서 상기 단편의 위치를 결정할 수 있으며 여러가지 효소를 사용하여 이 방법을 여러 회 수행함으로써, 단백질이 결합하는 핵산 서열의 신속한 결정을 용이하게 할 수 있다.
또한, 본 발명의 MCP 핵산 분자는 진화 연구 및 단백질 구조 연구에도 적합하다. 여러 원핵 세포 및 진핵 세포는 본 발명의 분자가 관여하는 대사 과정을 이용한다. 본 발명의 핵산 분자 서열을 다른 유기체에서의 유사 효소를 코딩하는 핵산 분자 서열과 비교함으로써 상기 유기체의 진화 관계 정도를 조사할 수 있다. 따라서, 이러한 비교를 통해 서열 영역이 보존되었는지의 여부를 결정할 수 있고, 이는 효소 기능에 필수적인 단백질의 보존 영역을 조사하는데 도움을 줄 수 있다. 이러한 방식의 조사는 단백질 조작 연구에 중요하며, 단백질에서 그의 기능 손실 없이 돌연변이유발을 허용할 수 있는 수준에 관한 지침을 제공할 수 있다.
본 발명의 MCP 단백질은 미지의 박테리아를 코리네박테리움 글루타미쿰으로 분류하거나 또는 샘플 내에서 코리네박테리움 글루타미쿰 또는 그와 밀접한 관련이 있는 박테리아에 대한 확인용 마커로 사용될 수 있다. 당업계에 공지된 기술을 이용하면, 예를 들어 적절한 경우에는 샘플 중의 세포 (예를 들어 적합한 배지 중에서 배양한 세포)를 증폭시켜 샘플량을 증가시킨 후에 상기 세포를 용균시켜, 그에 함유된 단백질이 방출되도록 할 수 있다. 적절한 경우에는, 샘플을 정제하여 이후의 분석을 방해할 수 있는 세포 잔해 및 핵산 분자를 제거할 수 있다. 본 발명의 선택된 MCP 단백질에 특이적인 항체를 단백질 샘플과 함께 전형적인 웨스턴 분석 포맷 (예를 들어 문헌 [Ausubel et al., (1988) Current Protocols in Molecular Biology, Wiley: New York] 참조)으로 인큐베이션시켜, 항체의 표적 단백질이 샘플 내에 존재하는 경우에는 상기 항체와 그 단백질이 결합하도록 할 수 있다. MCP 단백질이 코리네박테리움 글루타미쿰 또는 코리네박테리움 글루타미쿰 및 그와 매우밀접한 관련이 있는 박테리아에만 고유하거나 거의 고유한 경우에는, 이러한 유형의 분석을 통해 MCP 단백질을 선별한다. 이어서, 샘플 내의 단백질을 겔 전기영동으로 분리하고 니트로셀룰로스 등과 같은 적합한 매트릭스에 옮긴다. 검출가능한 표지 (예컨대 화학발광 표지 또는 비색 표지)가 부착된 적합한 2차 항체를 매트릭스와 함께 인큐베이션시킨 후에 엄격하게 세척한다. 상기 표지의 존재 또는 부재는 그 샘플 중 표적 단백질의 존재 또는 부재를 지시한다. 단백질이 존재한다면, 이것은 코리네박테리움 글루타미쿰의 존재를 나타낸다. 유사한 방법을 통해 미지의 박테리아를 코리네박테리움 글루타미쿰으로 분류할 수 있다. 미지의 박테리아에서 프렙 (preparation)한 단백질 샘플에서 코리네박테리움 글루타미쿰에 특이적인 수많은 단백질이 검출되지 않는다면, 이것은 그 박테리아가 코리네박테리움 글루타미쿰이 아닐 것임을 나타내는 것이다.
본 발명의 MCP 핵산 분자의 유전자 조작을 통해, 야생형 MCP 단백질과는 기능적으로 상이한 MCP 단백질이 생산되도록 할 수 있다. 이러한 단백질은 효율 또는 활성과 관련하여 개선될 수 있어서, 이들이 세포 내에 통상적인 수보다 더 많은 수로 존재하게 하거나 이들의 효율 또는 활성을 약화시킬 수도 있다.
이러한 활성 변화를 통해 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 직접 조정할 수 있다. 예를 들면, 정밀 화학물질의 생합성 또는 분해에 관여하는 단백질의 활성을 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)시켜 세포에 의한 상기 화합물의 합성능 또는 분해능을 직접 조정함으로써, 정밀 화학물질의 수율 및(또는) 생산 효율을 조정할 수 있다. 또한, 정밀 화학물질의 대사 경로를 조절하는 단백질의 활성을 조정함으로써 원하는 화합물 생산의 상향 또는 하향 조절에 직접적으로 영향을 미칠 수 있는데, 이러한 두 경우 모두가 세포로부터의 정밀 화학물질 수율 또는 생산 효율을 조정한다.
정밀 화학물질 생산의 간접 조정은 본 발명에 따른 단백질의 활성 변형 (즉, 상응하는 유전자의 돌연변이유발에 의한 변형)에 의해 수행되어, 세포의 성장력 및 분열력 또는 살아있는 상태로의 유지력 또는 생산성 유지력을 전반적으로 증가시킬 수도 있다. 통상적으로, 코리네박테리움 글루타미쿰으로부터의 정밀 화학물질 생산은 상기 미생물을 종종 세포 성장 및 세포 분열에 최적인 상태에 준하는 조건하에 대량으로 발효 배양함으로써 수행된다. 본 발명의 단백질 (예를 들어 스트레스 반응 단백질, 세포벽 단백질 또는 뉴클레오티드 및 아미노산 등과 같이 세포 분열 및 세포 성장 수행에 필요한 화합물의 대사에 관여하는 단백질)을 변형시켜 상기 조건하에서의 생존, 성장 및 전파를 개선시킴으로써, 상기 변형된 코리네박테리움 글루타미쿰 세포의 대량 배양시의 수 및 생산성이 증가되도록 할 수 있는데, 이는 1종 이상의 원하는 정밀 화학물질의 수율 및(또는) 생산 효율을 증가시키는 것이다. 이는 1종 이상의 원하는 정밀 화학물질의 수율 및(또는) 생산 효율을 증가시키는 것이다. 추가로, 세포의 대사 경로는 반드시 상호 의존적이고 동시 조절되는 것이다. 코리네박테리움 글루타미쿰의 임의의 대사 경로 활성을 변화시킴 (즉, 그러한 경로에 관여하는 본 발명의 단백질들 중 하나의 활성을 변화시킴)으로써 상기 미생물에서 정밀 화학물질의 합성 또는 분해에 직접적으로 관여할 수 있는 또다른대사 경로의 활성 또는 그에 대한 조절을 동시에 변화시킬 수 있다.
코리네박테리움 글루타미쿰으로부터의 정밀 화학물질 수율을 증가시키기 위해서 MCP 단백질을 돌연변이유발시키는 상기 전략들은 그에 제한되는 것이 아니다. 당업자에게는 이러한 돌연변이유발 전략들에 대한 변형법이 매우 명백하다. 이러한 전략을 사용하고 본원에 개시한 메카니즘을 포함시킴으로써, 돌연변이된 MCP 핵산 및 단백질 분자를 발현하는 코리네박테리움 글루타미쿰 또는 그와 관련된 박테리아 균주를 생성하여 관심 화합물의 수율, 생산량 및(또는) 생산 효율을 개선시키는데 본 발명의 핵산 및 단백질 분자를 이용할 수 있다. 상기 관심 화합물은, 생합성 경로의 최종 생성물 및 천연 대사 경로의 중간체 뿐 아니라 코리네박테리움 글루타미쿰 대사시에 천연적으로 생성되는 것은 아니지만 본 발명의 코리네박테리움 글루타미쿰 균주에 의해 생산되는 분자 등을 비롯하여 코리네박테리움 글루타미쿰에 의해 생산된 임의의 생성물일 수 있다.
하기 실시예는 본 발명을 추가로 예시하기 위한 것으로써, 본 발명을 제한하는 것으로 이해해서는 안된다. 본 명세서에서 인용한 모든 참고문헌, 특허 출원 명세서, 특허 문헌 및 공개된 특허 출원 명세서의 내용은 본원에 참고로 도입된다.
실시예 1: 코리네박테리움 글루타미쿰 ATCC13032의 전체 게놈 DNA의 프렙
BHI 배지 (디프코 (Difco) 제품) 중의 코리네박테리움 글루타미쿰 (ATCC 13032) 배양물을 30℃에서 격렬히 진탕시키면서 밤새 배양하였다. 원심분리하여 세포를 회수하여 상층액은 버리고, 세포를 완충액-I 5 mL (배양물 처음 부피의 5％에 해당함-언급한 모든 부피는 배양 부피 100 mL에 대해 계산한 값임) 중에 재현탁했다. 완충액-I의 조성은 다음과 같았다: 140.34 g/L 수크로스, 2.46 g/L MgS04×7 H2O, 10 mL/L KH2PO4용액 (100 g/L, KOH를 사용하여 pH 6.7로 조정함), 50 mL/L M12 농축물 (10 g/L (NH4)2SO4, 1 g/L NaCl, 2 g/L MgSO4×7 H2O, 0.2 g/L CaCl2, 0.5 g/L 효모 추출물 (디프코 제품), 10 mL/L 미량 원소 혼합물 (200 mg/L FeSO4×H2O, 10 mg/L ZnSO4×7 H2O, 3 mg/L MnCl2×4 H2O, 30 mg/L H3BO3, 20 mg/L CoCl2×6 H2O, 1 mg/L NiCl2×6 H2O, 3 mg/L Na2MoO4×2 H2O), 500 mg/L 착화제 (EDTA 또는 시트르산), 100 mL/L 비타민 혼합물 (0.2 mg/L 바이오틴, 0.2 mg/L 엽산, 20 mg/L p-아미노 벤조산, 20 mg/L 리보플라빈, 40 mg/L Ca 판토테네이트, 140 mg/L 니코틴산, 40 mg/L 피리독살 히드로클로라이드, 200 mg/L 미오이노시톨). 상기 현탁액에 리소짐을 최종 농도 2.5 mg/mL로 첨가했다. 37℃에서 대략 4시간 동안 인큐베이션시킨 후, 세포벽을 파괴하고 원심분리하여 원형질체를 수거했다. 펠렛을 완충액-I 5 mL로 1회 세척하고, TE 완충액 (10 mM Tris-HCl, 1 mM EDTA, pH 8) 5 mL로 1회 세척했다. 펠렛을 TE 완충액 4 mL 중에 재현탁하고, SDS 용액 (10％) 0.5 mL 및 NaCl 용액 (5 M) 0.5 mL을 첨가했다. 프로테이나제 K를 최종 농도 200 ㎍/mL로 첨가한 후, 상기 현탁액을 37℃에서 대략 18시간 동안 인큐베이션시켰다. 표준 방법에 따라 DNA를 페놀, 페놀/클로로포름/이소아밀 알콜 및 클로로포름/이소아밀 알콜로 추출하여 정제했다. 이어서, 1/50배 부피의 3 M 아세트산나트륨 및 2배 부피의 에탄올을 첨가하여 DNA를 침전시킨 후, -20℃에서 30분 동안 인큐베이션시키고, SS34 회전자 (소르발 (Sorvall) 제품)를 사용한 고속 원심분리기에서 12,000 rpm로 30분 동안 원심분리했다. DNA를 20 ㎍/mL RNaseA를 함유하는 TE 완충액 1 mL 중에 용해시키고, 4℃에서 3시간 이상 동안 TE 완충액 1000 mL 중에 투석했다. 투석 동안, 상기 완충액을 3회 교환하였다. 투석된 DNA 용액을 0.4 mL씩 분취하여, 2 M LiCl 0.4 mL 및 에탄올 0.8 mL을 첨가했다. -20℃에서 30분 동안 인큐베이션시킨 후, 원심분리 (13,000 rpm, 독일 하나우 헤래우스에 소재하는 바이오퓨지 프레스코 (Biofuge Fresco) 제품)하여 DNA를 수집했다. DNA 펠렛을 TE 완충액 중에 용해했다. 이 방법으로 프렙된 DNA를 서던 블럿팅 또는 게놈 뱅크 제작 등의 모든 목적에 이용했다.
실시예 2: 대장균에서 코리네박테리움 글루타미쿰 (ATCC13032)의 게놈 뱅크 제작
실시예 1에 기재한 바와 같이 프렙된 DNA를 사용하여, 공지되고 수립되어 있는 방법 (예를 들어 문헌 [Sambrook, J. et al. (1989) "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley ＆ Sons] 참조)에 따라 코스미드 및 플라스미드 뱅크를 제작했다.
임의의 플라스미드 또는 코스미드를 사용할 수 있었다. 특히, 플라스미드 pBR322 [Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75:3737-3741]; pACYC177 [Change ＆ Cohen (1978) J. Bacteriol 134:1141-1156], pBS 계열의 플라스미드 (pBSSK+, pBSSK- 등; 미국 라졸라에 소재하는 스트라타진 (Stratagene) 제품) 또는 SuperCos I (미국 라졸라에 소재하는 스트라타진 제품) 또는 Lorist6 [Gibson, T.J., Rosenthal A. and Waterson, R.H. (1987) Gene 53:283-286] 등의 코스미드를 사용하는 것이 바람직했다.
실시예 3: DNA 서열분석 및 컴퓨터를 이용한 기능 분석
실시예 2에 기재한 바와 같은 게놈 뱅크를 사용하여, 표준 방법, 특히 ABI377 서열 분석기를 사용한 쇄 종결 방법 (예를 들어 문헌 [Fleischman, R.D. et al. (1995) "Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd.", Science, 269:496-512])에 따른 DNA 서열분석을 수행했다. 하기 뉴클레오티드 서열을 갖는 서열분석 프라이머를 사용했다: 5'-GGAAACAGTATGACCATG-3' 또는 5'-GTAAAACGACGGCCAGT-3'.
실시예 4: 생체내 돌연변이유발
코리네박테리움 글루타미쿰의 생체내 돌연변이유발은 유전 정보의 통합성을 유지할 수 없는 대장균 또는 다른 미생물 (예를 들면, 바실러스 종 또는 사카로마이세스 세레비지애 등의 효모)에 플라스미드 (또는 다른 벡터) DNA를 계대배양하여 수행할 수 있다. 전형적인 돌연변이유발 균주는 DNA 복구 시스템에 관한 유전자 (예를 들면, mutHLS, mutD, mutT 등; 비교하기 위해서는 문헌 [Rupp, W.D. (1996) DNA repair mechanisms, in Escherichia coli and Salmonella, p.2277-2294, ASM: Washington] 참조)에 돌연변이가 있다. 이러한 균주들은 당업자에게 공지되어 있다. 이러한 균주의 사용법은 예를 들어 문헌 [Greener, A. and Callahan, M. (1994) Strategies 7:32-34]에 예시되어 있다.
실시예 5: 대장균과 코리네박테리움 글루타미쿰 사이의 DNA 전달
여러 코리네박테리움 및 브레비박테리움 종은 자율적으로 복제되는 내인성 플라스미드 (예를 들면, pHM1519 또는 pBL1 등)를 함유하고 있다 (이에 관해 검토하기 위해서는 예를 들어 문헌 [Martin, J.F. et al. (1987) Biotechnology, 5:137-146] 참조). 대장균 및 코리네박테리움 글루타미쿰에 사용하기 위한 셔틀 벡터는 대장균의 경우에 사용하는 표준 벡터 (문헌 [Sambrook, J. et al. (1989), "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley ＆ Sons])에 코리네박테리움 글루타미쿰의 복제 기점 및 적당한 마커를 부가하여 사용함으로써 쉽게 제작될 수 있다. 이러한 복제 기점은 코리네박테리움 및 브레비박테리움 종에서 단리한 내인성 플라스미드로부터 얻는 것이 바람직하다. 이들 종에 특히 유용한 형질전환 마커는 카나마이신 내성 유전자 (예를 들면, Tn5 또는 Tn903 트란스포손에서 유래함) 또는 클로람페니콜 내성 유전자 [Winnacker, E.L. (1987) "From Genes to Clones-Introduction to Gene Technology", VCH, Weinheim]이다. 대장균 및 코리네박테리움 글루타미쿰에서 복제되고 유전자 과다발현 등을 비롯한 각종 목적에 사용할 수 있는 매우 다양한 셔틀 벡터의 제조법에 관한 문헌들이 많이 있다 (예를 들어 [Yoshihama, M. et al. (1985) J. Bacteriol. 162:591-597], [Martin J.F. et al. (1987) Biotechnology, 5:137-146] 및 [Eikmanns, B.J. et al. (1991) Gene, 102:93-98] 참조).
표준 방법을 이용하여, 관심 유전자를 상기 기재한 셔틀 벡터들 중 하나에클로닝하고 이러한 하이브리드 벡터를 코리네박테리움 글루타미쿰 균주에 도입할 수 있다. 코리네박테리움 글루타미쿰은 원형질체 형질전환법 [Kastsumata, R. et al. (1984) J. Bacteriol. 159:306-311], 전기천공법 [Liebl, E. et al. (1989) FEMS Microbiol. Letters, 53:399-303]을 이용하고 특정 벡터가 사용되는 경우에는 접합법 (예를 들어 문헌 [Schaefer, A et al. (1990) J. Bacteriol. 172:1663-1666]에 기재된 바와 같음)도 이용하여 형질전환시킬 수 있다. 또한, 코리네박테리움 글루타미쿰으로부터 플라스미드 DNA를 프렙 (당업계에 공지된 표준 방법을 사용함)하고, 이것으로 대장균을 형질전환시켜 코리네박테리움 글루타미쿰의 셔틀 벡터를 대장균에 전달할 수도 있다. 이러한 형질전환 단계는 표준 방법으로 수행할 수 있지만, NM522 [Gough ＆ Murray (1983) J. Mol. Biol. 166:1-19] 등과 같은 Mcr-결핍 대장균 균주를 사용하는 것이 유리하다.
실시예 6: 돌연변이된 단백질의 발현 평가
형질전환된 숙주 세포에서 돌연변이된 단백질의 활성 관찰은 상기 돌연변이 단백질이 야생형 단백질과 유사한 방식 및 유사한 양으로 발현된다는 사실을 바탕으로 한다. 돌연변이된 유전자의 전사량 (유전자 생성물의 번역에 이용가능한 mRNA 양에 관한 지표) 측정에 적합한 방법은 관심 유전자에 결합하도록 고안되어 검출가능한 표지 (통상적으로 방사성 표지 또는 화학발광 표지)가 부착된 프라이머를 사용하여 노던 블럿팅 (예를 들어 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York] 참조)을 수행하는 것인데, 이는 유기체 배양물의 전체 RNA를 추출하고 겔상에서 분리하여 안정한 매트릭스에 옮긴 후에 상기 프로브와 인큐베이션시켜, 프로브의 결합 및 그 결합 활성이 상기 유전자에 대한 mRNA의 존재 여부 및 또한 그 존재량을 지시하는 방법이다. 이러한 정보는 돌연변이된 유전자의 전사 정도에 관한 지표가 된다. 예를 들어 문헌 [Bormann, E.R. et al. (1992) Mol. Microbiol. 6:317-326]에 기재된 것과 같이 당업계에 공지된 각종 방법들을 이용하여 코리네박테리움 글루타미쿰의 세포내 전체 RNA를 단리할 수 있다.
상기 mRNA로부터 번역된 단백질의 존재 여부 또는 그 상대량은 웨스턴 블럿팅과 같은 표준 기술을 사용하여 측정할 수 있다 (예를 들어 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York] 참조). 이 방법에서는, 세포내 전체 단백질을 추출하여 겔 전기영동법으로 분리한 후에 이를 니트로셀룰로스 등과 같은 매트릭스에 옮겨서 관심 단백질에 특이적으로 결합하는 항체 등과 같은 프로브와 함께 인큐베이션시킨다. 통상적으로, 이 프로브에는 쉽게 검출될 수 있는 화학발광 표지 또는 비색 표지가 부착되어 있다. 표지의 존재 여부 및 그의 관찰된 양은 그 세포 내에서 원하는 돌연변이 단백질의 존재 여부 및 그 존재량을 지시한다.
실시예 7: 유전자 변형된 코리네박테리움 글루타미쿰의 성장 - 배지 및 배양 조건
유전자 변형된 코리네박테리움을 합성 또는 천연 성장 배지에서 배양한다. 코리네박테리움을 위한 여러 다양한 성장 배지는 당업계에 공지되어 있으며 쉽게 입수가능하다 (문헌 [Lieb et al. (1989) Appl. Microbiol. Biotechnol. 32:205-210], [von der Osten et al. (1998) Biotechnology Letters, 11:11-16], 독일 특허 제4,120,867호, [Liebl (1992) "The Genus Corynebacterium", in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag]). 이들 배지는 1종 이상의 탄소 공급원, 질소 공급원, 무기염, 비타민 및 미량 원소로 구성된다. 바람직한 탄소 공급원은 단당류, 이당류 또는 다당류 등의 당이다. 매우 훌륭한 탄소 공급원의 예로는 글루코스, 프럭토스, 만노스, 갈락토스, 리보스, 소르보스, 리불로스, 락토스, 말토스, 수크로스, 라피노스, 녹말 및 셀룰로스 등이 있다. 또한, 당 정제시 생성되는 당밀 또는 기타 부산물 등과 같은 복합 화합물 등으로서 배지에 당을 공급할 수도 있다. 또한, 각종 탄소 공급원들의 혼합물을 첨가하는 것이 유리할 수도 있다. 다른 가능한 탄소 공급원은 메탄올, 에탄올, 아세트산 또는 락트산 등의 알콜 및 유기산이다. 질소 공급원은 통상적으로 유기 또는 무기 질소 화합물이거나 이러한 화합물을 함유하는 물질이다. 질소 공급원의 예로는 암모니아 기체 및 NH4Cl 또는 (NH4)2SO4, NH40H 등의 암모늄염, 질산염, 우레아, 아미노산 또는 옥수수 침유 (cornsteep liquor), 대두 가루, 대두 단백질, 효모 추출물, 육류 추출물 등과 같은 복합 질소 공급원 등이 있다.
배지에 함유시킬 수 있는 무기 염 화합물로는 칼슘, 마그네슘, 나트륨, 코발트, 몰리브덴, 칼륨, 망간, 아연, 구리 및 철의 염산염, 인산염 또는 황산염 등이 있다. 킬레이팅제를 배지에 첨가하여 금속 이온을 용액 중에 유지할 수 있다. 특히 적합한 킬레이팅제로는 카테콜 또는 프로토카테쿠에이트 등과 같은 디히드록시페놀 또는 시트르산 등의 유기산 등이 있다. 또한, 배지에는 통상적으로 비타민또는 성장 촉진제 등의 다른 성장 인자가 함유되어 있고, 이들의 예로는 바이오틴, 리보플라빈, 티아민, 엽산, 니코틴산, 판토테네이트 및 피리독신 등이 있다. 성장 인자 및 염은 흔히 효모 추출물, 당밀, 옥수수 침유 등과 같은 복합 배지 성분으로부터 생성된다. 배지의 정확한 조성은 특정 실험마다 크게 달라지고, 각 경우마다 따로 결정된다. 배지의 최적화에 관한 정보는 문헌 ["Applied Microbiol. Physiology, A Practical Approach (editors P.M. Rhodes, P.F. Stanbury, IRL Press (1997) pp.53-73, ISBN 0 19 963577 3)]에서 찾을 수 있다. 또한, 스탠다드 1 (Standard 1) (머크 (Merck) 제품) 또는 BHI (BrainHeartInfusion) (디프코 제품) 등과 같이 제조 회사가 시판하는 것을 구입할 수도 있다.
모든 배지 성분들을 열처리 (1.5 bar 및 121℃에서 20분) 또는 멸균 여과로 멸균시킨다. 이 성분들은 한꺼번에 멸균시킬 수도 있고 필요에 따라서는 따로 멸균시킬 수도 있다. 모든 배지 성분들은 배양 초기부터 함유시킬 수도 있고, 원한다면 연속적으로 또는 배치식으로 (batchwise) 첨가할 수도 있다.
배양 조건은 각 실험마다 따로 정의된다. 온도는 15℃와 45℃ 사이의 범위이어야 하고, 실험하는 동안 일정하게 유지시키거나 변경시킬 수 있다. 배지의 pH는 5 내지 8.5의 범위, 바람직하게는 약 7.0 정도이어야 하며, 배지에 완충액을 첨가하여 유지시킬 수 있다. 이러한 목적으로 사용할 수 있는 완충액의 예로는 인산칼륨 완충액 등이 있다. MOPS, HEPES, ACES 등과 같은 합성 완충액을 대안적으로 사용하거나 동시에 사용할 수 있다. 또한, 배양하는 동안 NaOH 또는 NH4OH를 첨가하여 pH를 일정하게 유지시킬 수도 있다. 효모 추출물 등의 복합 배지 성분이 사용되는 경우, 많은 복합 화합물들은 완충 성능이 높기 때문에 추가 완충액에 대한 요구를 감소시킬 수 있다. 미생물 배양에 발효기를 사용하는 경우, pH는 암모니아 기체를 사용하여 조절할 수도 있다.
인큐베이션 기간은 통상적으로 수 시간 내지 수 일이다. 이 시간은 브로쓰 (broth)에 축적되는 생성물의 양이 최대가 되도록 선택한다. 개시한 성장 실험을 다양한 크기의 미량역가 플레이트, 유리관, 유리 플라스크 또는 유리 또는 금속 발효기 등의 각종 용기에서 수행할 수 있다. 다수의 클론을 스크리닝하기 위해서는, 미생물을 배플 (baffle)이 있거나 없는 미량역가 플레이트, 유리관 또는 진탕 플라스크에서 배양해야 한다. 요구되는 성장 배지를 100 mL 진탕 플라스크에 10％ (부피 기준) 채워 사용하는 것이 바람직하다. 이 플라스크들은 100 내지 300 rpm 속력 범위의 회전 진탕기 상에서 진탕 (진폭 25 mm)되어야 한다. 대기를 습하게 유지함으로써 증발로 인한 손실량을 감소시키거나, 별법으로는 증발로 인한 손실량을 정확하게 보정해야 한다.
유전자 변형된 클론을 연구하는 경우, 변형되지 않은 대조 클론 또는 인서트가 없는 원래의 플라스미드를 함유하는 대조 클론도 분석해야 한다. CM 플레이트 (10 g/L 글루코스, 2.5 g/L NaCl, 2 g/L 우레아, 10 g/L 폴리펩톤, 5 g/L 효모 추출물, 5 g/L 육류 추출물, 22 g/L 아가, 2 M NaOH을 사용하여 pH 6.8로 조정) 등과 같은 아가 플레이트 상에서 30℃에서 인큐베이션하여 성장시킨 세포를 OD600이 0.5내지 1.5가 되도록 배지에 접종한다. 배지 접종은 CM 플레이트로부터의 코리네박테리움 글루타미쿰 세포의 염수 용액을 도입하거나, 상기 박테리아의 예비배양액을 첨가하여 수행한다.
실시예 8: 돌연변이된 단백질의 기능에 관한 시험관내 분석
효소의 활성 및 반응 속도 (kinetics) 측정법은 당업계에 공지되어 있다. 특정하게 변형된 효소의 활성 측정 실험은 야생형 효소의 비활성(比活性)에 맞추어야 하며, 당업자라면 이를 잘 수행할 수 있다. 효소에 관한 일반적인 개요 뿐만 아니라 효소의 구조, 반응 속도, 원리, 방법, 적용에 관한 구체적인 세부사항 및 많은 효소들의 활성 측정 방법의 예는 예를 들어 하기의 참고문헌에서 찾을 수 있다: [Dixon, M., and Webb, E.C., (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York], [Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: SanFrancisco], [Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford], [Boyer, P.D., ed. (1983) The Enzymes, 3rd edition. Academic Press: New York], [Bisswanger, H., (1994) Enzymkinetik, 2nd edition. VCH: Weinheim (ISBN 3527300325)], [Bergmeyer, H.U., Bergmeyer, J., Grassl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3rd edition, vol.I-XII, Verlag Chemie: Weinheim] 및 [Ullmann's Encyclopedia of Industrial Chemistry (1987) vol.A9, "Enzymes". VCH: Weinheim, p.352-363].
DNA에 결합하는 단백질의 활성은 DNA 밴드-변위 (bandshift) 분석법 (겔 지연 분석법 (gel retardation assays)이라고 지칭하기도 함) 등과 같이 잘 수립되어 있는 여러 방법들을 사용하여 측정할 수 있다. 상기 단백질들이 다른 분자들의 발현에 미치는 영향은 리포터 유전자 분석법 (예를 들어 문헌 [Kolmar, H. et al. (1995) EMBO J. 14:3895-3904]과 그의 참고문헌에 기재된 바와 같음)을 사용하여 측정할 수 있다. β-갈락토시다제 등의 효소, 녹색 형광 단백질 및 여러가지 기타 효소가 사용되는 리포터 유전자 시험 시스템은 원핵 세포 및 진핵 세포 모두에의 적용에 대해 공지되어 있으며 잘 수립되어 있다.
막 수송 단백질의 활성은 문헌 [Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p.85-137, 199-234 및 270-322]에 기재된 기술에 따라 측정할 수 있다.
실시예 9: 돌연변이된 단백질이 관심 생성물의 생산에 미치는 영향 분석
코리네박테리움 글루타미쿰에서의 유전자 변형이 관심 화합물 (예컨대 아미노산)의 생산에 미치는 영향은 변형된 미생물을 적합한 조건 (예를 들어 상기 기재한 조건)하에서 성장시키고, 관심 생성물 (즉, 아미노산)의 생산 증가에 관여한 배지 성분 및(또는) 세포내 성분을 시험하여 결정할 수 있다. 이러한 분석 기술은 당업자에게 공지되어 있으며, 분광분석법, 박층 크로마토그래피법, 각종 유형의 착색법, 효소적 및 미생물학적 방법 및 고성능 액체 크로마토그래피법 등과 같은 분석용 크로마토그래피법 등이 있다 (예를 들어 문헌 ([Ullman, Encyclopedia of Industrial Chemistry, vol.A2, p.89-90 및 p.443-613, VCH: Weinheim (1985)],[Fallon, A. et al., (1987) "Applications of HPLC in Biochemistry" in: Laboratory Techniques in Biochemistry and Molecular Biology, vol.17], [Rehm et al. (1993) Biotechnology, vol.3, Chapter III: "Product recovery and purification", page 469-714, VCH: Weinheim], [Belter, P.A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons], [Kennedy, J.F. and Cabral, J.M.S. (1992) Recovery processes for biological materials, John Wiley and Sons], [Shaeiwitz, J.A. and Henry, J.D. (1988) Biochemical separations, in Ulmann's Encyclopedia of Industrial Chemistry, vol.B3, Chapter 11, page 1-27, VCH: Weinheim] 및 [Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications]) 참조).
최종 발효 생성물의 측정 뿐만 아니라, 중간체 및 부산물 등과 같이 관심 화합물의 생산에 이용된 대사 경로 중의 다른 성분들을 분석함으로써 전반적인 화합물 생산 효율을 측정할 수도 있다. 분석 방법으로는 배지 내의 영양분 (예컨대 당, 탄화수소, 질소 공급원, 인산염 및 기타 이온) 함량 측정, 생물집단 (biomass)의 조성 및 성장 측정, 생합성 경로의 공통 대사물질의 생산 분석 및 발효 동안에 생성된 기체의 측정 등이 있다. 이러한 측정을 위한 표준 방법은 문헌 [Applied Microbial Physiology, A Practical Approach, P.M.Rhodes and P.F.Stanbury, eds., IRL Press, p.103-129, 131-163 및 165-192 (ISBN:0199635773)과 그의 참고문헌]에 기재되어 있다.
실시예 10: 코리네박테리움 글루타미쿰 배양물로부터의 관심 생성물 정제
당업계에 공지된 여러가지 방법을 사용하여, 코리네박테리움 글루타미쿰 세포 또는 상기 기재한 배양물의 상층액으로부터 관심 생성물을 수득할 수 있다. 세포가 관심 생성물을 분비하지 않는 경우에는 배양물을 저속 원심분리하여 세포를 수거하고 기계적인 힘이나 초음파 등과 같은 표준 기술로 세포를 용균시킬 수 있다. 원심분리로 세포 잔해를 제거하여 가용성 단백질을 함유하는 상층액 분획물을 수득하고, 이를 사용하여 관심 화합물을 추가로 정제한다. 코리네박테리움 글루타미쿰 세포가 생성물을 분비하는 경우에는 배양물을 저속 원심분리하여 세포를 제거하고, 수득한 상층액 분획물을 추가로 정제한다.
상기 두 가지 정제 방법 모두의 경우에서 수득한 상층액 분획물을 적합한 수지를 사용한 크로마토그래피에 적용하여 관심 분자는 크로마토그래피 수지 상에 남지만 샘플 중의 많은 오염물질들은 남지 않게 하거나, 오염물질들은 수지에 남지만 원하는 분자는 남지 않게 한다. 필요에 따라서는, 동일하거나 상이한 크로마토그래피 수지를 사용하여 이러한 크로마토그래피 단계를 반복할 수 있다. 당업자라면, 적합한 크로마토그래피 수지를 선택하고 정제할 특정 분자에 대해 가장 효과적으로 이를 적용하는 것에 숙달되어 있을 것이다. 정제된 생성물을 여과 또는 한외여과사켜 농축시키고, 생성물의 안정성이 최대가 되는 온도에 저장할 수 있다.
당업계에는 상기 기재한 정제법 및 예를 들어 문헌 [Bailey, J.E. ＆ Ollis, D.F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986)]에 기재된 정제법 등을 포함하나 이에 제한되지 않는 여러가지 정제법들이 공지되어 있다.
단리된 화합물의 확인 및 순도는 당업계의 기술로 측정할 수 있다. 이러한 기술로는 고성능 액체 크로마토그래피법 (HPLC), 분광분석법, 착색법, 박층 크로마토그래피법, NIRS법, 효소 분석법 또는 미생물학적 분석법 등이 있다. 이러한 분석 방법은 하기 문헌에서 고찰된다: [Patek et al. (1994) Appl. Environ. Microbiol. 60:133-140], [Malakhova et al. (1996) Biotekhnologiya 11:27-32], [Schmidt et al. (1998) Bioprocess Engineer. 19:67-70], [Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol.A27, VCH: Weinheim, p.89-90, p.521-540, p.540-547, p.559-566, p.575-581 및 p.581-587], [Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons] 및 [Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol.17].
등가물
당업자라면, 단순한 통상의 방법을 이용하여 본 발명의 특정 실시양태의 수많은 등가물을 알아내거나 확인할 수 있다. 이러한 등가물은 하기하는 청구의 범위에 포함된다.
표 1의 정보는 다음과 같이 이해되어야 한다:
컬럼 1에서, "DNA 서열 번호"의 해당 번호는 첨부된 서열 목록에서의 서열 번호 각각을 지칭하는 것이다. 따라서, 컬럼 "DNA 서열 번호"의 "5"는 서열 5를 지칭한다.
컬럼 2에서, "아미노산 서열 번호"의 해당 번호는 첨부된 서열 목록에서의 서열 번호 각각을 지칭하는 것이다. 따라서, 컬럼 "아미노산 서열 번호"의 "6"은 서열 6을 지칭한다.
컬럼 3에서, "확인"은 각 서열에 대한 명확한 식별기호를 기재한 것이다.
컬럼 4에서, "아미노산 위치"의 해당 번호는 각 경우에서 동일 열에 있는 "아미노산 서열 번호"에 기재된 폴리펩티드 서열에서의 아미노산 위치를 지칭한다. 따라서, 컬럼 "아미노산 위치"의 "26"은 해당 폴리펩티드 서열의 아미노산 위치 26이다. 위치 번호는 N 말단을 +1로 하여 출발한다.
컬럼 5에서, "아미노산 야생형"의 해당 문자는 각 경우의 컬럼 4에 표시한 야생형 서열에서 해당 위치에 존재하는 아미노산을 지칭하며, 1문자 코드로 나타내었다.
컬럼 6에서, "아미노산 돌연변이체"의 해당 문자는 각 경우의 컬럼 4에 표시한 돌연변이체 서열에서 해당 위치에 존재하는 아미노산을 지칭하며, 1문자 코드로 나타내었다.
컬럼 7에서, "기능"은 해당 폴리펩티드 서열의 생리적 기능을 기재한 것이다.
단백질성 아미노산의 1문자 코드는 다음과 같다:
A 알라닌
C 시스테인
D 아스파르트산
E 글루탐산
F 페닐알라닌
G 글리신
H 히스티딘
I 이소루이신
K 리신
L 루이신
M 메티오닌
N 아스파라긴
P 프롤린
Q 글루타민
R 아르기닌
S 세린
T 트레오닌
V 발린
W 트립토판
Y 티로신
<110> BASF Aktiengesellschaft <120> Genes coding for novel proteins <130> O.Z. 0050/52976 <160> 434 <210> 1 <211> 1465 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1435) <223> RXA00033 <400> 1 acacggattt aacgtgacgg tttctcagtg tttttagctt ctggcttttg gcttctgatg 60 ctttagcgct ggactcaaca tttaaaacaa aggtgaacac atg tca gta cag caa 115 Met Ser Val Gln Gln 1 5 agc ggg ttg ctc gaa cgt ctc ggc att ccc cga ccc ttg att ttc gga 163 Ser Gly Leu Leu Glu Arg Leu Gly Ile Pro Arg Pro Leu Ile Phe Gly 10 15 20 ttt atc ggc ctc acc atc ttc atg atc ggt gac ggt gtc gaa acc aac 211 Phe Ile Gly Leu Thr Ile Phe Met Ile Gly Asp Gly Val Glu Thr Asn 25 30 35 att ttg gaa cct ttc ctc agt tcc gaa cat ggt ttc agc gtt tcc ctc 259 Ile Leu Glu Pro Phe Leu Ser Ser Glu His Gly Phe Ser Val Ser Leu 40 45 50 gcg gga acc ctg gtg act gtt tac ggt gtt gcc gtg gcg atc gca gca 307 Ala Gly Thr Leu Val Thr Val Tyr Gly Val Ala Val Ala Ile Ala Ala 55 60 65 ttc ttc gcg gcg gca ctt tcg gac ctg tgg ggt cca cga aaa gtg atg 355 Phe Phe Ala Ala Ala Leu Ser Asp Leu Trp Gly Pro Arg Lys Val Met 70 75 80 85 atc ctc ggt gct tca atc tgg atc gtc ttt gag ctg atc ttc ctc acc 403 Ile Leu Gly Ala Ser Ile Trp Ile Val Phe Glu Leu Ile Phe Leu Thr 90 95 100 gtg gca ctg acc acc gac cat act tgg ttg atc ttc ctt gct tat ggt 451 Val Ala Leu Thr Thr Asp His Thr Trp Leu Ile Phe Leu Ala Tyr Gly 105 110 115 ctc cgc ggc ttt ggt tat cca ttc ttc gcc tac gga ttc ttg gtg tgg 499 Leu Arg Gly Phe Gly Tyr Pro Phe Phe Ala Tyr Gly Phe Leu Val Trp 120 125 130 atc acc gca act gcc tca cct aag caa ttg ggt acc ggt gtg ggt tgg 547 Ile Thr Ala Thr Ala Ser Pro Lys Gln Leu Gly Thr Gly Val Gly Trp 135 140 145 ttc tac gtt gcc ttc tct gca ggt ctt cct acc ttg ggt gcg ctg gtt 595 Phe Tyr Val Ala Phe Ser Ala Gly Leu Pro Thr Leu Gly Ala Leu Val 150 155 160 165 gcc acc att tcc atg cag tac gtg aac ttg acc ttc tat gaa acg ttg 643 Ala Thr Ile Ser Met Gln Tyr Val Asn Leu Thr Phe Tyr Glu Thr Leu 170 175 180 tgg gtt tcc ctc gtg ctg gtg gtc atc gga tcg ctc atc gca ctg ctg 691 Trp Val Ser Leu Val Leu Val Val Ile Gly Ser Leu Ile Ala Leu Leu 185 190 195 gga gtg aag gaa cgt cgc gga cgc cac cca ctg gtt gcc aac ccc gac 739 Gly Val Lys Glu Arg Arg Gly Arg His Pro Leu Val Ala Asn Pro Asp 200 205 210 gat gtg aag caa aca ctt ggc cag ggc ttc aaa ctt ctg cgc aat gat 787 Asp Val Lys Gln Thr Leu Gly Gln Gly Phe Lys Leu Leu Arg Asn Asp 215 220 225 cga cgt gca cgt ttt gtc acc tac atc cgc acc atc aac tcc att ccg 835 Arg Arg Ala Arg Phe Val Thr Tyr Ile Arg Thr Ile Asn Ser Ile Pro 230 235 240 245 acc tac gcg atg gct gtg ttc ttc cca tca ttt ttc act gac gat ctg 883 Thr Tyr Ala Met Ala Val Phe Phe Pro Ser Phe Phe Thr Asp Asp Leu 250 255 260 aag tgg cag cta agc tgg ttc ctc atc ctc acc act gta att tac gca 931 Lys Trp Gln Leu Ser Trp Phe Leu Ile Leu Thr Thr Val Ile Tyr Ala 265 270 275 gtc aac ctg ccg ttc aat cct ttc ttc ggt agc ttc ggc gac cgc cac 979 Val Asn Leu Pro Phe Asn Pro Phe Phe Gly Ser Phe Gly Asp Arg His 280 285 290 ggt tgg gca cga act gtg ttc tgg ggc gga tca atc ggt ggc gca gtc 1027 Gly Trp Ala Arg Thr Val Phe Trp Gly Gly Ser Ile Gly Gly Ala Val 295 300 305 acc ctc gcg ttg gtt tac ttc att ccg atg ttc ggc gtt cag gct ggc 1075 Thr Leu Ala Leu Val Tyr Phe Ile Pro Met Phe Gly Val Gln Ala Gly 310 315 320 325 atg tcc aac ggt gtc gtt ttc gga atc acc atc gca gcc ggc gca ctc 1123 Met Ser Asn Gly Val Val Phe Gly Ile Thr Ile Ala Ala Gly Ala Leu 330 335 340 ttt ggt gtg tcc ctc gcg ggc ttc gtg cca ctt tcc gca atc gct gtc 1171 Phe Gly Val Ser Leu Ala Gly Phe Val Pro Leu Ser Ala Ile Ala Val 345 350 355 tcc ctt gat ccc aag cac ccc ggc gca gcg atg gcc aca tac aac ctc 1219 Ser Leu Asp Pro Lys His Pro Gly Ala Ala Met Ala Thr Tyr Asn Leu 360 365 370 ggc gtt ggt ggc gct gta gct gtg gga ccg ctc ctg gtt gca gtc ttc 1267 Gly Val Gly Gly Ala Val Ala Val Gly Pro Leu Leu Val Ala Val Phe 375 380 385 cac cca ctg att ggt cca acc gga ttg atc ctg gtc atg atc gcc ctc 1315 His Pro Leu Ile Gly Pro Thr Gly Leu Ile Leu Val Met Ile Ala Leu 390 395 400 405 tac ctg ctc tcc ggt tgg atg act ctt caa ctt cgc ggc acc caa cca 1363 Tyr Leu Leu Ser Gly Trp Met Thr Leu Gln Leu Arg Gly Thr Gln Pro 410 415 420 gga ttc gac gga gtg cca gca ctt gct gaa gac gcc cac atc gaa gac 1411 Gly Phe Asp Gly Val Pro Ala Leu Ala Glu Asp Ala His Ile Glu Asp 425 430 435 ctt gca gat gta aac gca aac gcc taactgtttt tcgagctaaa cccatccttg 1465 Leu Ala Asp Val Asn Ala Asn Ala 440 445 <210> 2 <211> 445 <212> PRT <213> Corynebacterium glutamicum <400> 2 Met Ser Val Gln Gln Ser Gly Leu Leu Glu Arg Leu Gly Ile Pro Arg 1 5 10 15 Pro Leu Ile Phe Gly Phe Ile Gly Leu Thr Ile Phe Met Ile Gly Asp 20 25 30 Gly Val Glu Thr Asn Ile Leu Glu Pro Phe Leu Ser Ser Glu His Gly 35 40 45 Phe Ser Val Ser Leu Ala Gly Thr Leu Val Thr Val Tyr Gly Val Ala 50 55 60 Val Ala Ile Ala Ala Phe Phe Ala Ala Ala Leu Ser Asp Leu Trp Gly 65 70 75 80 Pro Arg Lys Val Met Ile Leu Gly Ala Ser Ile Trp Ile Val Phe Glu 85 90 95 Leu Ile Phe Leu Thr Val Ala Leu Thr Thr Asp His Thr Trp Leu Ile 100 105 110 Phe Leu Ala Tyr Gly Leu Arg Gly Phe Gly Tyr Pro Phe Phe Ala Tyr 115 120 125 Gly Phe Leu Val Trp Ile Thr Ala Thr Ala Ser Pro Lys Gln Leu Gly 130 135 140 Thr Gly Val Gly Trp Phe Tyr Val Ala Phe Ser Ala Gly Leu Pro Thr 145 150 155 160 Leu Gly Ala Leu Val Ala Thr Ile Ser Met Gln Tyr Val Asn Leu Thr 165 170 175 Phe Tyr Glu Thr Leu Trp Val Ser Leu Val Leu Val Val Ile Gly Ser 180 185 190 Leu Ile Ala Leu Leu Gly Val Lys Glu Arg Arg Gly Arg His Pro Leu 195 200 205 Val Ala Asn Pro Asp Asp Val Lys Gln Thr Leu Gly Gln Gly Phe Lys 210 215 220 Leu Leu Arg Asn Asp Arg Arg Ala Arg Phe Val Thr Tyr Ile Arg Thr 225 230 235 240 Ile Asn Ser Ile Pro Thr Tyr Ala Met Ala Val Phe Phe Pro Ser Phe 245 250 255 Phe Thr Asp Asp Leu Lys Trp Gln Leu Ser Trp Phe Leu Ile Leu Thr 260 265 270 Thr Val Ile Tyr Ala Val Asn Leu Pro Phe Asn Pro Phe Phe Gly Ser 275 280 285 Phe Gly Asp Arg His Gly Trp Ala Arg Thr Val Phe Trp Gly Gly Ser 290 295 300 Ile Gly Gly Ala Val Thr Leu Ala Leu Val Tyr Phe Ile Pro Met Phe 305 310 315 320 Gly Val Gln Ala Gly Met Ser Asn Gly Val Val Phe Gly Ile Thr Ile 325 330 335 Ala Ala Gly Ala Leu Phe Gly Val Ser Leu Ala Gly Phe Val Pro Leu 340 345 350 Ser Ala Ile Ala Val Ser Leu Asp Pro Lys His Pro Gly Ala Ala Met 355 360 365 Ala Thr Tyr Asn Leu Gly Val Gly Gly Ala Val Ala Val Gly Pro Leu 370 375 380 Leu Val Ala Val Phe His Pro Leu Ile Gly Pro Thr Gly Leu Ile Leu 385 390 395 400 Val Met Ile Ala Leu Tyr Leu Leu Ser Gly Trp Met Thr Leu Gln Leu 405 410 415 Arg Gly Thr Gln Pro Gly Phe Asp Gly Val Pro Ala Leu Ala Glu Asp 420 425 430 Ala His Ile Glu Asp Leu Ala Asp Val Asn Ala Asn Ala 435 440 445 <210> 3 <211> 3043 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3013) <223> RXA00054 <400> 3 atgctgagat ccgctgggtg gcaccacacg aattggaatc tttggagtgg gcacctgctg 60 atattcctgc ggtgaaactt ctcgtcgagc agcttgctta atg agc cca ttc gat 115 Met Ser Pro Phe Asp 1 5 tca aag ctt ggt cgc gat acc cat ttt gga ttc ctc gat aag acc act 163 Ser Lys Leu Gly Arg Asp Thr His Phe Gly Phe Leu Asp Lys Thr Thr 10 15 20 gct tcg caa caa ctg ctg aat cct tca ttg att tct aat gag gat ccg 211 Ala Ser Gln Gln Leu Leu Asn Pro Ser Leu Ile Ser Asn Glu Asp Pro 25 30 35 cac acc atg ttg cag gcg atc aag tta gag ctt cgt acc gca cag tct 259 His Thr Met Leu Gln Ala Ile Lys Leu Glu Leu Arg Thr Ala Gln Ser 40 45 50 ttt aca ttt tca gtc gct ttt att tcc agt cgc ggt atc gcg ttg ttg 307 Phe Thr Phe Ser Val Ala Phe Ile Ser Ser Arg Gly Ile Ala Leu Leu 55 60 65 aaa cag gca ttg ttg gac ttc aag ggt aaa gga cga att atc acg tcc 355 Lys Gln Ala Leu Leu Asp Phe Lys Gly Lys Gly Arg Ile Ile Thr Ser 70 75 80 85 cgc tac ctg gat ttc aat gat cca acg atg ttt cgt gag ctt ctt act 403 Arg Tyr Leu Asp Phe Asn Asp Pro Thr Met Phe Arg Glu Leu Leu Thr 90 95 100 ttg gag aac gtg gaa gtc ctc ata cat caa ggc gat ggt ttc cac tcc 451 Leu Glu Asn Val Glu Val Leu Ile His Gln Gly Asp Gly Phe His Ser 105 110 115 aag ggc tac gtt ttc cat cac gac gtg gga atc acc gca gta gtg ggt 499 Lys Gly Tyr Val Phe His His Asp Val Gly Ile Thr Ala Val Val Gly 120 125 130 agt tcc aac ctc aca gat aat gct ctg ttg gta aac cgg gaa tgg aat 547 Ser Ser Asn Leu Thr Asp Asn Ala Leu Leu Val Asn Arg Glu Trp Asn 135 140 145 ctg aag ttc tct gcc agc aag aat ggc gac att gct ttt caa ctt gat 595 Leu Lys Phe Ser Ala Ser Lys Asn Gly Asp Ile Ala Phe Gln Leu Asp 150 155 160 165 gat gcg att aat cgc caa att gaa cga tcc acg cca ctg acg cct gaa 643 Asp Ala Ile Asn Arg Gln Ile Glu Arg Ser Thr Pro Leu Thr Pro Glu 170 175 180 tgg atc tca gag tat gag gca acc aga cgt gta cct gag cgt ttg gtg 691 Trp Ile Ser Glu Tyr Glu Ala Thr Arg Arg Val Pro Glu Arg Leu Val 185 190 195 tct cag aat att cct ctc gag gat caa agt aac gcc gga aca att gtt 739 Ser Gln Asn Ile Pro Leu Glu Asp Gln Ser Asn Ala Gly Thr Ile Val 200 205 210 cca aac gtc atg cag gaa gag gcc ctc gac gct cta ctt tct ttg acg 787 Pro Asn Val Met Gln Glu Glu Ala Leu Asp Ala Leu Leu Ser Leu Thr 215 220 225 gag aag gga gag aaa cgt ggt gtc att att tct gcg aca gga act ggc 835 Glu Lys Gly Glu Lys Arg Gly Val Ile Ile Ser Ala Thr Gly Thr Gly 230 235 240 245 aag act atc ctg gct gct cta gct aca aga atg ctc aag cct gaa cga 883 Lys Thr Ile Leu Ala Ala Leu Ala Thr Arg Met Leu Lys Pro Glu Arg 250 255 260 gtt ttg ttt gtc gtg cac cgc gaa caa att ctg gat aag gcg cga tcc 931 Val Leu Phe Val Val His Arg Glu Gln Ile Leu Asp Lys Ala Arg Ser 265 270 275 gag ttc atc aaa gtt ctt gaa cgt ccc gct gtt gat ttc gga aaa atg 979 Glu Phe Ile Lys Val Leu Glu Arg Pro Ala Val Asp Phe Gly Lys Met 280 285 290 tct ggc tcg acc aag gag cta gat aag ccg ttt gtg ttt ggc acc atc 1027 Ser Gly Ser Thr Lys Glu Leu Asp Lys Pro Phe Val Phe Gly Thr Ile 295 300 305 caa acg ctg aca aag gaa gct aca ctt tcc cag atc tcc cct act gac 1075 Gln Thr Leu Thr Lys Glu Ala Thr Leu Ser Gln Ile Ser Pro Thr Asp 310 315 320 325 ttt gat tta gtc atc gtc gat gaa gtc cat cgc gcc ggt gcc gaa tcc 1123 Phe Asp Leu Val Ile Val Asp Glu Val His Arg Ala Gly Ala Glu Ser 330 335 340 tat ttg gca ttg ctc aat cat ctg cag cca cag ttt tta ttg ggc ctg 1171 Tyr Leu Ala Leu Leu Asn His Leu Gln Pro Gln Phe Leu Leu Gly Leu 345 350 355 act gct acc cca gag cga act gat gga ttc aat att tat gag ttg ttc 1219 Thr Ala Thr Pro Glu Arg Thr Asp Gly Phe Asn Ile Tyr Glu Leu Phe 360 365 370 gat ttc aac gtg cca tat gag atc cga ctt caa gct gct tta gaa tcc 1267 Asp Phe Asn Val Pro Tyr Glu Ile Arg Leu Gln Ala Ala Leu Glu Ser 375 380 385 aac atg ctc gta ccg ttt cac tat tac ggt gtc aca gac ttc acg ctt 1315 Asn Met Leu Val Pro Phe His Tyr Tyr Gly Val Thr Asp Phe Thr Leu 390 395 400 405 gat tct gaa aca acg gtg act gat acc tcc aaa cta agt gcc ttg gtg 1363 Asp Ser Glu Thr Thr Val Thr Asp Thr Ser Lys Leu Ser Ala Leu Val 410 415 420 agc gaa gag aga gtc cat cac att ctg gag gcc ctc aaa act tat ggt 1411 Ser Glu Glu Arg Val His His Ile Leu Glu Ala Leu Lys Thr Tyr Gly 425 430 435 cat cca gaa aat gtt cgt gga ctg atc ttc tgt tcc aag act gaa gag 1459 His Pro Glu Asn Val Arg Gly Leu Ile Phe Cys Ser Lys Thr Glu Glu 440 445 450 gct gag gag ctg tca aaa ctt ctc gac cag tcg ttg ttt aat ggc agc 1507 Ala Glu Glu Leu Ser Lys Leu Leu Asp Gln Ser Leu Phe Asn Gly Ser 455 460 465 ttg ctt aaa acc aag gcg ctc tct gcg aag gac tca att ccc tac cgc 1555 Leu Leu Lys Thr Lys Ala Leu Ser Ala Lys Asp Ser Ile Pro Tyr Arg 470 475 480 485 gaa gag gtt gta gct gag ctg gag tcc ggc gac ctg gac tac atc ttg 1603 Glu Glu Val Val Ala Glu Leu Glu Ser Gly Asp Leu Asp Tyr Ile Leu 490 495 500 acg gtt gac atc ttc aat gaa ggc att gat att cct tcg gtg aat caa 1651 Thr Val Asp Ile Phe Asn Glu Gly Ile Asp Ile Pro Ser Val Asn Gln 505 510 515 atc gta atg att cgt agt act caa tca agc att gtg ttt acg cag cag 1699 Ile Val Met Ile Arg Ser Thr Gln Ser Ser Ile Val Phe Thr Gln Gln 520 525 530 ctc ggg cgt gga ctc cga aaa gct gct ggc aaa gac cat ctg cgc gtt 1747 Leu Gly Arg Gly Leu Arg Lys Ala Ala Gly Lys Asp His Leu Arg Val 535 540 545 att gat ttc att ggc aac tac gcg aac aac tat ctc att ccc atc gca 1795 Ile Asp Phe Ile Gly Asn Tyr Ala Asn Asn Tyr Leu Ile Pro Ile Ala 550 555 560 565 ttg ttt ggc gat aat tct cgc aat aag aac agc atc aga cgc cgc ctg 1843 Leu Phe Gly Asp Asn Ser Arg Asn Lys Asn Ser Ile Arg Arg Arg Leu 570 575 580 att gag agc gat att gat gga aca atc tca ggt gtt tca agt gtt aac 1891 Ile Glu Ser Asp Ile Asp Gly Thr Ile Ser Gly Val Ser Ser Val Asn 585 590 595 ttt gat ccc atc gcg cag gag aga att ttt gct gcg ttg aag gct gcg 1939 Phe Asp Pro Ile Ala Gln Glu Arg Ile Phe Ala Ala Leu Lys Ala Ala 600 605 610 aag ttg gac tca aaa gca caa ttc aag cag gat att gtt cag ctt caa 1987 Lys Leu Asp Ser Lys Ala Gln Phe Lys Gln Asp Ile Val Gln Leu Gln 615 620 625 gat cga ctc aat cat gtg cca gca ctg tta gac ttc gct cgc ttc aat 2035 Asp Arg Leu Asn His Val Pro Ala Leu Leu Asp Phe Ala Arg Phe Asn 630 635 640 645 act gtt gat ccg ttt atc ctt gcc acg cat tct ggc aac tac tgg tcg 2083 Thr Val Asp Pro Phe Ile Leu Ala Thr His Ser Gly Asn Tyr Trp Ser 650 655 660 ctg ctc agt tca gtg aag ttt gtc gat cac gct ccc agc gaa tcg gag 2131 Leu Leu Ser Ser Val Lys Phe Val Asp His Ala Pro Ser Glu Ser Glu 665 670 675 aag tac ttt ctg gat ttc ctt acc gga gag ctt ctt aac ggc aag cga 2179 Lys Tyr Phe Leu Asp Phe Leu Thr Gly Glu Leu Leu Asn Gly Lys Arg 680 685 690 cct cat gag ctg ttg ctg atc cag gaa cta atg aaa cag cct gaa act 2227 Pro His Glu Leu Leu Leu Ile Gln Glu Leu Met Lys Gln Pro Glu Thr 695 700 705 tct act gaa gaa ttc cgt aag ctc ttg cag gcc caa tcg act agt tca 2275 Ser Thr Glu Glu Phe Arg Lys Leu Leu Gln Ala Gln Ser Thr Ser Ser 710 715 720 725 gat gag caa aca atc aac tcg gtt gaa agg att ttg agc caa gaa ttc 2323 Asp Glu Gln Thr Ile Asn Ser Val Glu Arg Ile Leu Ser Gln Glu Phe 730 735 740 tat acg gga cca aac cgc aag aag ttt ggc gaa cat ccg atc ctc tct 2371 Tyr Thr Gly Pro Asn Arg Lys Lys Phe Gly Glu His Pro Ile Leu Ser 745 750 755 gtt caa aac cgc acc tac tct ttt act ccc gag ttc cga cgt gcc ctc 2419 Val Gln Asn Arg Thr Tyr Ser Phe Thr Pro Glu Phe Arg Arg Ala Leu 760 765 770 gac gaa agc cta gaa gtg acg gac cga gat gag gct gct cag aat ttt 2467 Asp Glu Ser Leu Glu Val Thr Asp Arg Asp Glu Ala Ala Gln Asn Phe 775 780 785 aag ttt cac gtc caa gac atc atc gac act ggt ttg ttt atc gcc aga 2515 Lys Phe His Val Gln Asp Ile Ile Asp Thr Gly Leu Phe Ile Ala Arg 790 795 800 805 aac aat gga ttt tgg caa gga aac ctc gtt gtt ggc gag aga tac tcc 2563 Asn Asn Gly Phe Trp Gln Gly Asn Leu Val Val Gly Glu Arg Tyr Ser 810 815 820 cga cga gat gtc tgc cga att ctc aat tgg gaa cga aac aac gag agc 2611 Arg Arg Asp Val Cys Arg Ile Leu Asn Trp Glu Arg Asn Asn Glu Ser 825 830 835 acg att tat gga tac aaa gtg gac agt tac aca tct act tgc cca atc 2659 Thr Ile Tyr Gly Tyr Lys Val Asp Ser Tyr Thr Ser Thr Cys Pro Ile 840 845 850 ttt gtg acc tat cac aag gct gat gat gta tcc gaa agt act cgt tac 2707 Phe Val Thr Tyr His Lys Ala Asp Asp Val Ser Glu Ser Thr Arg Tyr 855 860 865 cag gat gaa ctc gtc gat ccg aat acc ctt cat tgg tat tcc cgc ggc 2755 Gln Asp Glu Leu Val Asp Pro Asn Thr Leu His Trp Tyr Ser Arg Gly 870 875 880 885 aac cga aag atc acg tct aat gag atc aag ccc atc gct gcg aat gct 2803 Asn Arg Lys Ile Thr Ser Asn Glu Ile Lys Pro Ile Ala Ala Asn Ala 890 895 900 gtg gat ctt cat gtt ttt gtg aag aag gac gat gcc gaa ggc ctt gat 2851 Val Asp Leu His Val Phe Val Lys Lys Asp Asp Ala Glu Gly Leu Asp 905 910 915 ttc ttc tac ctt ggt caa gcg cat tca gaa aac agc aaa cag tca tcg 2899 Phe Phe Tyr Leu Gly Gln Ala His Ser Glu Asn Ser Lys Gln Ser Ser 920 925 930 atg ccc gga aac aaa gga gtt gtg caa ccg gtg gtc aca atg gat cta 2947 Met Pro Gly Asn Lys Gly Val Val Gln Pro Val Val Thr Met Asp Leu 935 940 945 cag ttc gac aca ccc gtc gaa caa agc ctg ttt gag tac ctg agc aca 2995 Gln Phe Asp Thr Pro Val Glu Gln Ser Leu Phe Glu Tyr Leu Ser Thr 950 955 960 965 aat ctc gcc gta acg gag taaccaccgc aaccaagcgt cgaaaagcaa 3043 Asn Leu Ala Val Thr Glu 970 <210> 4 <211> 971 <212> PRT <213> Corynebacterium glutamicum <400> 4 Met Ser Pro Phe Asp Ser Lys Leu Gly Arg Asp Thr His Phe Gly Phe 1 5 10 15 Leu Asp Lys Thr Thr Ala Ser Gln Gln Leu Leu Asn Pro Ser Leu Ile 20 25 30 Ser Asn Glu Asp Pro His Thr Met Leu Gln Ala Ile Lys Leu Glu Leu 35 40 45 Arg Thr Ala Gln Ser Phe Thr Phe Ser Val Ala Phe Ile Ser Ser Arg 50 55 60 Gly Ile Ala Leu Leu Lys Gln Ala Leu Leu Asp Phe Lys Gly Lys Gly 65 70 75 80 Arg Ile Ile Thr Ser Arg Tyr Leu Asp Phe Asn Asp Pro Thr Met Phe 85 90 95 Arg Glu Leu Leu Thr Leu Glu Asn Val Glu Val Leu Ile His Gln Gly 100 105 110 Asp Gly Phe His Ser Lys Gly Tyr Val Phe His His Asp Val Gly Ile 115 120 125 Thr Ala Val Val Gly Ser Ser Asn Leu Thr Asp Asn Ala Leu Leu Val 130 135 140 Asn Arg Glu Trp Asn Leu Lys Phe Ser Ala Ser Lys Asn Gly Asp Ile 145 150 155 160 Ala Phe Gln Leu Asp Asp Ala Ile Asn Arg Gln Ile Glu Arg Ser Thr 165 170 175 Pro Leu Thr Pro Glu Trp Ile Ser Glu Tyr Glu Ala Thr Arg Arg Val 180 185 190 Pro Glu Arg Leu Val Ser Gln Asn Ile Pro Leu Glu Asp Gln Ser Asn 195 200 205 Ala Gly Thr Ile Val Pro Asn Val Met Gln Glu Glu Ala Leu Asp Ala 210 215 220 Leu Leu Ser Leu Thr Glu Lys Gly Glu Lys Arg Gly Val Ile Ile Ser 225 230 235 240 Ala Thr Gly Thr Gly Lys Thr Ile Leu Ala Ala Leu Ala Thr Arg Met 245 250 255 Leu Lys Pro Glu Arg Val Leu Phe Val Val His Arg Glu Gln Ile Leu 260 265 270 Asp Lys Ala Arg Ser Glu Phe Ile Lys Val Leu Glu Arg Pro Ala Val 275 280 285 Asp Phe Gly Lys Met Ser Gly Ser Thr Lys Glu Leu Asp Lys Pro Phe 290 295 300 Val Phe Gly Thr Ile Gln Thr Leu Thr Lys Glu Ala Thr Leu Ser Gln 305 310 315 320 Ile Ser Pro Thr Asp Phe Asp Leu Val Ile Val Asp Glu Val His Arg 325 330 335 Ala Gly Ala Glu Ser Tyr Leu Ala Leu Leu Asn His Leu Gln Pro Gln 340 345 350 Phe Leu Leu Gly Leu Thr Ala Thr Pro Glu Arg Thr Asp Gly Phe Asn 355 360 365 Ile Tyr Glu Leu Phe Asp Phe Asn Val Pro Tyr Glu Ile Arg Leu Gln 370 375 380 Ala Ala Leu Glu Ser Asn Met Leu Val Pro Phe His Tyr Tyr Gly Val 385 390 395 400 Thr Asp Phe Thr Leu Asp Ser Glu Thr Thr Val Thr Asp Thr Ser Lys 405 410 415 Leu Ser Ala Leu Val Ser Glu Glu Arg Val His His Ile Leu Glu Ala 420 425 430 Leu Lys Thr Tyr Gly His Pro Glu Asn Val Arg Gly Leu Ile Phe Cys 435 440 445 Ser Lys Thr Glu Glu Ala Glu Glu Leu Ser Lys Leu Leu Asp Gln Ser 450 455 460 Leu Phe Asn Gly Ser Leu Leu Lys Thr Lys Ala Leu Ser Ala Lys Asp 465 470 475 480 Ser Ile Pro Tyr Arg Glu Glu Val Val Ala Glu Leu Glu Ser Gly Asp 485 490 495 Leu Asp Tyr Ile Leu Thr Val Asp Ile Phe Asn Glu Gly Ile Asp Ile 500 505 510 Pro Ser Val Asn Gln Ile Val Met Ile Arg Ser Thr Gln Ser Ser Ile 515 520 525 Val Phe Thr Gln Gln Leu Gly Arg Gly Leu Arg Lys Ala Ala Gly Lys 530 535 540 Asp His Leu Arg Val Ile Asp Phe Ile Gly Asn Tyr Ala Asn Asn Tyr 545 550 555 560 Leu Ile Pro Ile Ala Leu Phe Gly Asp Asn Ser Arg Asn Lys Asn Ser 565 570 575 Ile Arg Arg Arg Leu Ile Glu Ser Asp Ile Asp Gly Thr Ile Ser Gly 580 585 590 Val Ser Ser Val Asn Phe Asp Pro Ile Ala Gln Glu Arg Ile Phe Ala 595 600 605 Ala Leu Lys Ala Ala Lys Leu Asp Ser Lys Ala Gln Phe Lys Gln Asp 610 615 620 Ile Val Gln Leu Gln Asp Arg Leu Asn His Val Pro Ala Leu Leu Asp 625 630 635 640 Phe Ala Arg Phe Asn Thr Val Asp Pro Phe Ile Leu Ala Thr His Ser 645 650 655 Gly Asn Tyr Trp Ser Leu Leu Ser Ser Val Lys Phe Val Asp His Ala 660 665 670 Pro Ser Glu Ser Glu Lys Tyr Phe Leu Asp Phe Leu Thr Gly Glu Leu 675 680 685 Leu Asn Gly Lys Arg Pro His Glu Leu Leu Leu Ile Gln Glu Leu Met 690 695 700 Lys Gln Pro Glu Thr Ser Thr Glu Glu Phe Arg Lys Leu Leu Gln Ala 705 710 715 720 Gln Ser Thr Ser Ser Asp Glu Gln Thr Ile Asn Ser Val Glu Arg Ile 725 730 735 Leu Ser Gln Glu Phe Tyr Thr Gly Pro Asn Arg Lys Lys Phe Gly Glu 740 745 750 His Pro Ile Leu Ser Val Gln Asn Arg Thr Tyr Ser Phe Thr Pro Glu 755 760 765 Phe Arg Arg Ala Leu Asp Glu Ser Leu Glu Val Thr Asp Arg Asp Glu 770 775 780 Ala Ala Gln Asn Phe Lys Phe His Val Gln Asp Ile Ile Asp Thr Gly 785 790 795 800 Leu Phe Ile Ala Arg Asn Asn Gly Phe Trp Gln Gly Asn Leu Val Val 805 810 815 Gly Glu Arg Tyr Ser Arg Arg Asp Val Cys Arg Ile Leu Asn Trp Glu 820 825 830 Arg Asn Asn Glu Ser Thr Ile Tyr Gly Tyr Lys Val Asp Ser Tyr Thr 835 840 845 Ser Thr Cys Pro Ile Phe Val Thr Tyr His Lys Ala Asp Asp Val Ser 850 855 860 Glu Ser Thr Arg Tyr Gln Asp Glu Leu Val Asp Pro Asn Thr Leu His 865 870 875 880 Trp Tyr Ser Arg Gly Asn Arg Lys Ile Thr Ser Asn Glu Ile Lys Pro 885 890 895 Ile Ala Ala Asn Ala Val Asp Leu His Val Phe Val Lys Lys Asp Asp 900 905 910 Ala Glu Gly Leu Asp Phe Phe Tyr Leu Gly Gln Ala His Ser Glu Asn 915 920 925 Ser Lys Gln Ser Ser Met Pro Gly Asn Lys Gly Val Val Gln Pro Val 930 935 940 Val Thr Met Asp Leu Gln Phe Asp Thr Pro Val Glu Gln Ser Leu Phe 945 950 955 960 Glu Tyr Leu Ser Thr Asn Leu Ala Val Thr Glu 965 970 <210> 5 <211> 934 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(904) <223> RXA00056 <400> 5 caccacaggc ttccggaagt tgcacattgg aaaaaccctt agataaatat tgaaatatga 60 atttaataat agattccgaa cgaaatcggt gttagcgtct gtg ctg aaa caa tct 115 Val Leu Lys Gln Ser 1 5 aat cgc gtt tca gga cac cta cat gat cag gag ctc ttt ttg tta aac 163 Asn Arg Val Ser Gly His Leu His Asp Gln Glu Leu Phe Leu Leu Asn 10 15 20 aga gtc agt cgt att gca ggc gct tct gca atc aca cta tgc atc ggc 211 Arg Val Ser Arg Ile Ala Gly Ala Ser Ala Ile Thr Leu Cys Ile Gly 25 30 35 tta acc aca ata cta agc cct act tcc act gca caa agc ctc gaa cag 259 Leu Thr Thr Ile Leu Ser Pro Thr Ser Thr Ala Gln Ser Leu Glu Gln 40 45 50 atc acc cct tta cct gaa tct gca atc gac ctc aac gcc gag att cac 307 Ile Thr Pro Leu Pro Glu Ser Ala Ile Asp Leu Asn Ala Glu Ile His 55 60 65 gta aac aca agc gac att tca gct gaa cag atc ctt ggt gct caa gat 355 Val Asn Thr Ser Asp Ile Ser Ala Glu Gln Ile Leu Gly Ala Gln Asp 70 75 80 85 gaa atc aca act atg tac gat tct cat gac ccc tac gag tac ttc gat 403 Glu Ile Thr Thr Met Tyr Asp Ser His Asp Pro Tyr Glu Tyr Phe Asp 90 95 100 acc ctc acc gac atc gaa cag cgt tca ata ata gca gcg ctt aaa cgg 451 Thr Leu Thr Asp Ile Glu Gln Arg Ser Ile Ile Ala Ala Leu Lys Arg 105 110 115 gat ccg agt tca ctc caa caa cgc caa gaa acc cgt ctc gcg gca cag 499 Asp Pro Ser Ser Leu Gln Gln Arg Gln Glu Thr Arg Leu Ala Ala Gln 120 125 130 tcc gac ccc tac aaa att tac ata tca ggc ctc gaa atg ctt tca tgc 547 Ser Asp Pro Tyr Lys Ile Tyr Ile Ser Gly Leu Glu Met Leu Ser Cys 135 140 145 atc aat cta gtt gat gtt gta tca tgc ggg att gca aac caa gca gca 595 Ile Asn Leu Val Asp Val Val Ser Cys Gly Ile Ala Asn Gln Ala Ala 150 155 160 165 acc aaa gca aat aat gag gct gtc gca cga tac cca ggc gat tcc ctt 643 Thr Lys Ala Asn Asn Glu Ala Val Ala Arg Tyr Pro Gly Asp Ser Leu 170 175 180 cgc aac ggc aaa ggc gat gca ttt cgg cat tgc tca tgg aac gct ctg 691 Arg Asn Gly Lys Gly Asp Ala Phe Arg His Cys Ser Trp Asn Ala Leu 185 190 195 atg acg ata cga atc ggg agc aat gga gct gaa aga att gca aca aac 739 Met Thr Ile Arg Ile Gly Ser Asn Gly Ala Glu Arg Ile Ala Thr Asn 200 205 210 cac gag aca atc ggg gac ggt ccg gcc gat gaa aat gca atg gac cta 787 His Glu Thr Ile Gly Asp Gly Pro Ala Asp Glu Asn Ala Met Asp Leu 215 220 225 ttc aat aat gca caa ggc cga cag atc gga gcc gga ttc att aat agt 835 Phe Asn Asn Ala Gln Gly Arg Gln Ile Gly Ala Gly Phe Ile Asn Ser 230 235 240 245 aag gat gaa act agc gcg ctc gcg ata tgc gcg ctg tgg aca aat ctc 883 Lys Asp Glu Thr Ser Ala Leu Ala Ile Cys Ala Leu Trp Thr Asn Leu 250 255 260 ggt aga cta aaa act cta aaa taagcaaggt gccctctgat gctaaaaaag 934 Gly Arg Leu Lys Thr Leu Lys 265 <210> 6 <211> 268 <212> PRT <213> Corynebacterium glutamicum <400> 6 Val Leu Lys Gln Ser Asn Arg Val Ser Gly His Leu His Asp Gln Glu 1 5 10 15 Leu Phe Leu Leu Asn Arg Val Ser Arg Ile Ala Gly Ala Ser Ala Ile 20 25 30 Thr Leu Cys Ile Gly Leu Thr Thr Ile Leu Ser Pro Thr Ser Thr Ala 35 40 45 Gln Ser Leu Glu Gln Ile Thr Pro Leu Pro Glu Ser Ala Ile Asp Leu 50 55 60 Asn Ala Glu Ile His Val Asn Thr Ser Asp Ile Ser Ala Glu Gln Ile 65 70 75 80 Leu Gly Ala Gln Asp Glu Ile Thr Thr Met Tyr Asp Ser His Asp Pro 85 90 95 Tyr Glu Tyr Phe Asp Thr Leu Thr Asp Ile Glu Gln Arg Ser Ile Ile 100 105 110 Ala Ala Leu Lys Arg Asp Pro Ser Ser Leu Gln Gln Arg Gln Glu Thr 115 120 125 Arg Leu Ala Ala Gln Ser Asp Pro Tyr Lys Ile Tyr Ile Ser Gly Leu 130 135 140 Glu Met Leu Ser Cys Ile Asn Leu Val Asp Val Val Ser Cys Gly Ile 145 150 155 160 Ala Asn Gln Ala Ala Thr Lys Ala Asn Asn Glu Ala Val Ala Arg Tyr 165 170 175 Pro Gly Asp Ser Leu Arg Asn Gly Lys Gly Asp Ala Phe Arg His Cys 180 185 190 Ser Trp Asn Ala Leu Met Thr Ile Arg Ile Gly Ser Asn Gly Ala Glu 195 200 205 Arg Ile Ala Thr Asn His Glu Thr Ile Gly Asp Gly Pro Ala Asp Glu 210 215 220 Asn Ala Met Asp Leu Phe Asn Asn Ala Gln Gly Arg Gln Ile Gly Ala 225 230 235 240 Gly Phe Ile Asn Ser Lys Asp Glu Thr Ser Ala Leu Ala Ile Cys Ala 245 250 255 Leu Trp Thr Asn Leu Gly Arg Leu Lys Thr Leu Lys 260 265 <210> 7 <211> 760 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(730) <223> RXA00065 <400> 7 tggcaccgtc gctgcctcca gttgaggaac ttgaggttgc catggatggc gtggctacct 60 gtgtgctgtt ggcagcagcg gagcattacg ctaactaaaa gtg aat aca gcg gag 115 Val Asn Thr Ala Glu 1 5 aca gca cat tgg att aac cgt ctg ctt cct ggg aca ccg gaa ttc cac 163 Thr Ala His Trp Ile Asn Arg Leu Leu Pro Gly Thr Pro Glu Phe His 10 15 20 cag gtt ggc gcg ttt aaa gtg gca ggt tac acg ctt gag gat gaa tca 211 Gln Val Gly Ala Phe Lys Val Ala Gly Tyr Thr Leu Glu Asp Glu Ser 25 30 35 att gcg tgt tct gtc aat ttc ggg cgc gtc aac acc ggg ctg gtc acg 259 Ile Ala Cys Ser Val Asn Phe Gly Arg Val Asn Thr Gly Leu Val Thr 40 45 50 gaa ggc ggc gcg gaa acg gtc gat gtg cga agt gag att ttg agc ctg 307 Glu Gly Gly Ala Glu Thr Val Asp Val Arg Ser Glu Ile Leu Ser Leu 55 60 65 gcc agg gcc gac gtg tcc gtg cct ggg cgc gcc gtc ggc gct gct gca 355 Ala Arg Ala Asp Val Ser Val Pro Gly Arg Ala Val Gly Ala Ala Ala 70 75 80 85 aca atg ctt ctc gac gcc tcc ctc tcc ttc aaa tcc gcc acc gat tcc 403 Thr Met Leu Leu Asp Ala Ser Leu Ser Phe Lys Ser Ala Thr Asp Ser 90 95 100 agc gtc act ccc atg cat gcc caa ccg gga cag atc ttg ccg tgc gta 451 Ser Val Thr Pro Met His Ala Gln Pro Gly Gln Ile Leu Pro Cys Val 105 110 115 gga att atg gcg aat ctt ccc caa gag ggt ttt tct gtg gtg cac gga 499 Gly Ile Met Ala Asn Leu Pro Gln Glu Gly Phe Ser Val Val His Gly 120 125 130 att ttg gcg gat ccc cgc att tgg ggc ccg gag att ccg tat gtt cgt 547 Ile Leu Ala Asp Pro Arg Ile Trp Gly Pro Glu Ile Pro Tyr Val Arg 135 140 145 gaa gaa gca ggt caa gta aat gtg gaa gca ccc gac gag gct ggc gat 595 Glu Glu Ala Gly Gln Val Asn Val Glu Ala Pro Asp Glu Ala Gly Asp 150 155 160 165 cta gcc cga ttg acg ttg cct ctg cag ttg atc ctg ctc acg gag gaa 643 Leu Ala Arg Leu Thr Leu Pro Leu Gln Leu Ile Leu Leu Thr Glu Glu 170 175 180 gag ttt gcc atc gct ctc aac gag ggc agc gac gtc atg ttc gaa cga 691 Glu Phe Ala Ile Ala Leu Asn Glu Gly Ser Asp Val Met Phe Glu Arg 185 190 195 atg gcg gag caa gaa gtc gat ctt ctg gat ctg aaa cgt taagacggta 740 Met Ala Glu Gln Glu Val Asp Leu Leu Asp Leu Lys Arg 200 205 210 ggctcaattc cgtggctttg 760 <210> 8 <211> 210 <212> PRT <213> Corynebacterium glutamicum <400> 8 Val Asn Thr Ala Glu Thr Ala His Trp Ile Asn Arg Leu Leu Pro Gly 1 5 10 15 Thr Pro Glu Phe His Gln Val Gly Ala Phe Lys Val Ala Gly Tyr Thr 20 25 30 Leu Glu Asp Glu Ser Ile Ala Cys Ser Val Asn Phe Gly Arg Val Asn 35 40 45 Thr Gly Leu Val Thr Glu Gly Gly Ala Glu Thr Val Asp Val Arg Ser 50 55 60 Glu Ile Leu Ser Leu Ala Arg Ala Asp Val Ser Val Pro Gly Arg Ala 65 70 75 80 Val Gly Ala Ala Ala Thr Met Leu Leu Asp Ala Ser Leu Ser Phe Lys 85 90 95 Ser Ala Thr Asp Ser Ser Val Thr Pro Met His Ala Gln Pro Gly Gln 100 105 110 Ile Leu Pro Cys Val Gly Ile Met Ala Asn Leu Pro Gln Glu Gly Phe 115 120 125 Ser Val Val His Gly Ile Leu Ala Asp Pro Arg Ile Trp Gly Pro Glu 130 135 140 Ile Pro Tyr Val Arg Glu Glu Ala Gly Gln Val Asn Val Glu Ala Pro 145 150 155 160 Asp Glu Ala Gly Asp Leu Ala Arg Leu Thr Leu Pro Leu Gln Leu Ile 165 170 175 Leu Leu Thr Glu Glu Glu Phe Ala Ile Ala Leu Asn Glu Gly Ser Asp 180 185 190 Val Met Phe Glu Arg Met Ala Glu Gln Glu Val Asp Leu Leu Asp Leu 195 200 205 Lys Arg 210 <210> 9 <211> 712 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(682) <223> RXA00068 <400> 9 ggctgctaaa cggcaaccaa tagagcgata attcgctaag gcgaatgtaa tcgcagcaac 60 atatagcacc ggcttaacag gccggtgcta ttctgttcgc atg act tcg aag gat 115 Met Thr Ser Lys Asp 1 5 ctg att gtg acc tcc tat acg tct tgg ggc aag cgt ttc aag aat gac 163 Leu Ile Val Thr Ser Tyr Thr Ser Trp Gly Lys Arg Phe Lys Asn Asp 10 15 20 ggg aag ctt ttt att aac cta ctt cgc agc acc act gat agt gct gat 211 Gly Lys Leu Phe Ile Asn Leu Leu Arg Ser Thr Thr Asp Ser Ala Asp 25 30 35 gaa aag gtt tta gcc act ttc ggt gaa gtt ccc agc aaa tca ttt gaa 259 Glu Lys Val Leu Ala Thr Phe Gly Glu Val Pro Ser Lys Ser Phe Glu 40 45 50 acc acc gca acg gtt gat gag cag cag tgg gaa ctg tcc ttc agt att 307 Thr Thr Ala Thr Val Asp Glu Gln Gln Trp Glu Leu Ser Phe Ser Ile 55 60 65 gat gga acg gca act gcc aag ctt cct gat ggt cgt gtg ttc agc gcg 355 Asp Gly Thr Ala Thr Ala Lys Leu Pro Asp Gly Arg Val Phe Ser Ala 70 75 80 85 aat gca ggt gag aag acc ttt acc aag tcc aag cgg att gaa atc gac 403 Asn Ala Gly Glu Lys Thr Phe Thr Lys Ser Lys Arg Ile Glu Ile Asp 90 95 100 atg gac ggc acc gcg atg gct gct gtt aat gaa gat aaa aac aat tgg 451 Met Asp Gly Thr Ala Met Ala Ala Val Asn Glu Asp Lys Asn Asn Trp 105 110 115 att atc gac gat tct gaa gag aat aaa gtc gct cag ttt acc ggt atg 499 Ile Ile Asp Asp Ser Glu Glu Asn Lys Val Ala Gln Phe Thr Gly Met 120 125 130 aac aac ggt gtg cgt cgc gcg att gtg gag ttt gag cct gac gta gaa 547 Asn Asn Gly Val Arg Arg Ala Ile Val Glu Phe Glu Pro Asp Val Glu 135 140 145 gtc acc cag gag cag gaa att ttc ttg tcg tgg gtt gct cgg aaa act 595 Val Thr Gln Glu Gln Glu Ile Phe Leu Ser Trp Val Ala Arg Lys Thr 150 155 160 165 ctg gaa tcc cgc atg ttg ggc tcc agt tgg gga ctg act ctg ttt ttg 643 Leu Glu Ser Arg Met Leu Gly Ser Ser Trp Gly Leu Thr Leu Phe Leu 170 175 180 atc att ttg acg cca atc att att ttc ctc act ttc agc taaaaggacc 692 Ile Ile Leu Thr Pro Ile Ile Ile Phe Leu Thr Phe Ser 185 190 atgcaatggt agacgctcag 712 <210> 10 <211> 194 <212> PRT <213> Corynebacterium glutamicum <400> 10 Met Thr Ser Lys Asp Leu Ile Val Thr Ser Tyr Thr Ser Trp Gly Lys 1 5 10 15 Arg Phe Lys Asn Asp Gly Lys Leu Phe Ile Asn Leu Leu Arg Ser Thr 20 25 30 Thr Asp Ser Ala Asp Glu Lys Val Leu Ala Thr Phe Gly Glu Val Pro 35 40 45 Ser Lys Ser Phe Glu Thr Thr Ala Thr Val Asp Glu Gln Gln Trp Glu 50 55 60 Leu Ser Phe Ser Ile Asp Gly Thr Ala Thr Ala Lys Leu Pro Asp Gly 65 70 75 80 Arg Val Phe Ser Ala Asn Ala Gly Glu Lys Thr Phe Thr Lys Ser Lys 85 90 95 Arg Ile Glu Ile Asp Met Asp Gly Thr Ala Met Ala Ala Val Asn Glu 100 105 110 Asp Lys Asn Asn Trp Ile Ile Asp Asp Ser Glu Glu Asn Lys Val Ala 115 120 125 Gln Phe Thr Gly Met Asn Asn Gly Val Arg Arg Ala Ile Val Glu Phe 130 135 140 Glu Pro Asp Val Glu Val Thr Gln Glu Gln Glu Ile Phe Leu Ser Trp 145 150 155 160 Val Ala Arg Lys Thr Leu Glu Ser Arg Met Leu Gly Ser Ser Trp Gly 165 170 175 Leu Thr Leu Phe Leu Ile Ile Leu Thr Pro Ile Ile Ile Phe Leu Thr 180 185 190 Phe Ser <210> 11 <211> 1492 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1462) <223> RXA00077 <400> 11 ctaaattgtt ttaacgcgtg aagcagtccc cgcccgattt attcgaggcg gggactttcg 60 ctttccggga taaaaattgc aacgcactac actgagcagt atg aat gat gag aat 115 Met Asn Asp Glu Asn 1 5 att caa agc tcc aac tat cag cca ttc ccg agt ttt gac gat tgg aaa 163 Ile Gln Ser Ser Asn Tyr Gln Pro Phe Pro Ser Phe Asp Asp Trp Lys 10 15 20 cag atc gag gtg tcg ctc tta gat gtc atc gaa tcc tca cgc cat ttt 211 Gln Ile Glu Val Ser Leu Leu Asp Val Ile Glu Ser Ser Arg His Phe 25 30 35 tct gat ttg aaa gat agc act gat cgt tct gcg tta gat gct gcg cta 259 Ser Asp Leu Lys Asp Ser Thr Asp Arg Ser Ala Leu Asp Ala Ala Leu 40 45 50 gag aga gca aaa aga gct gcc gca gtt gat acc aat gcc ata gaa gga 307 Glu Arg Ala Lys Arg Ala Ala Ala Val Asp Thr Asn Ala Ile Glu Gly 55 60 65 atc ttc caa act gat cgc ggt ttt acc cat aca gtt gca acg cag gta 355 Ile Phe Gln Thr Asp Arg Gly Phe Thr His Thr Val Ala Thr Gln Val 70 75 80 85 ggg gct tgg gag caa caa atg gcg atg aaa ggc aaa cat gtt aag cct 403 Gly Ala Trp Glu Gln Gln Met Ala Met Lys Gly Lys His Val Lys Pro 90 95 100 gcg ttt gac gat act cta gaa ggc ttt gag tat gtt ctc gat gca gta 451 Ala Phe Asp Asp Thr Leu Glu Gly Phe Glu Tyr Val Leu Asp Ala Val 105 110 115 act ggt aga act cca atc tct cag caa tgg att aga aat ttg cac gcc 499 Thr Gly Arg Thr Pro Ile Ser Gln Gln Trp Ile Arg Asn Leu His Ala 120 125 130 gtc att ctg cgg agc caa gaa agc cac gag gtt ttt aca gcc gtt gga 547 Val Ile Leu Arg Ser Gln Glu Ser His Glu Val Phe Thr Ala Val Gly 135 140 145 gtc caa aat cag gcg ctt cag aaa ggc gag tat aaa act cag cca aat 595 Val Gln Asn Gln Ala Leu Gln Lys Gly Glu Tyr Lys Thr Gln Pro Asn 150 155 160 165 agt cca cag cgc tca gat gga tct gta cat gca tac gcc cca gtt gaa 643 Ser Pro Gln Arg Ser Asp Gly Ser Val His Ala Tyr Ala Pro Val Glu 170 175 180 gat act cct gct gaa atg gct aga ttt att tca gaa ctt gaa tct aag 691 Asp Thr Pro Ala Glu Met Ala Arg Phe Ile Ser Glu Leu Glu Ser Lys 185 190 195 gaa ttc tta gca gcc gag aag gtt att caa gct gcc tat gcc cac tat 739 Glu Phe Leu Ala Ala Glu Lys Val Ile Gln Ala Ala Tyr Ala His Tyr 200 205 210 gct ttc gta tgt att cat cct ttt gca gat ggg aat gga cga gtt gca 787 Ala Phe Val Cys Ile His Pro Phe Ala Asp Gly Asn Gly Arg Val Ala 215 220 225 cga gcc ttg gct agt gtt ttt cta tac aaa gat cct ggt gtc cct ctc 835 Arg Ala Leu Ala Ser Val Phe Leu Tyr Lys Asp Pro Gly Val Pro Leu 230 235 240 245 gta atc tac caa gat caa cgc aga gat tac atc cat gct cta gaa gca 883 Val Ile Tyr Gln Asp Gln Arg Arg Asp Tyr Ile His Ala Leu Glu Ala 250 255 260 gcg gac aag aat aac ccg ctc ctg ctg att aga ttc ttt gct gaa cga 931 Ala Asp Lys Asn Asn Pro Leu Leu Leu Ile Arg Phe Phe Ala Glu Arg 265 270 275 gtg acc gat act att aac tct att atc gtt gat ctc act acc ccg atc 979 Val Thr Asp Thr Ile Asn Ser Ile Ile Val Asp Leu Thr Thr Pro Ile 280 285 290 gcg ggt aaa tct ggt tcg gct aag ctt tcg gat gcg cta cgc ccc act 1027 Ala Gly Lys Ser Gly Ser Ala Lys Leu Ser Asp Ala Leu Arg Pro Thr 295 300 305 cgc gta tta cca gaa tta cat gat gct gca cat agg ctc caa gaa agt 1075 Arg Val Leu Pro Glu Leu His Asp Ala Ala His Arg Leu Gln Glu Ser 310 315 320 325 tta ttt aca gaa atc cga tct cga ttg gat gaa gaa gga aaa agg aat 1123 Leu Phe Thr Glu Ile Arg Ser Arg Leu Asp Glu Glu Gly Lys Arg Asn 330 335 340 ggg ttg gag ttt cta ctt caa cgg att ttt atc ggt tcc cca ttc aat 1171 Gly Leu Glu Phe Leu Leu Gln Arg Ile Phe Ile Gly Ser Pro Phe Asn 345 350 355 ctg cca gag ggc tat aac gct ttc cct gat agc tat tgt ctg acc tta 1219 Leu Pro Glu Gly Tyr Asn Ala Phe Pro Asp Ser Tyr Cys Leu Thr Leu 360 365 370 gct ttc aat agc aac tct cca aaa caa atc ttc cac ccg cta tcc ata 1267 Ala Phe Asn Ser Asn Ser Pro Lys Gln Ile Phe His Pro Leu Ser Ile 375 380 385 gta ata gca gct cga gat ggg aaa aga gcg agc agc gac ctc gtg gca 1315 Val Ile Ala Ala Arg Asp Gly Lys Arg Ala Ser Ser Asp Leu Val Ala 390 395 400 405 gct act tct att gga tac aac ttt cac gct tac gga cgt gaa gtc gag 1363 Ala Thr Ser Ile Gly Tyr Asn Phe His Ala Tyr Gly Arg Glu Val Glu 410 415 420 cct gtt gtt act gaa agc ttt cga gaa cgt gtg aaa att tac gcc gac 1411 Pro Val Val Thr Glu Ser Phe Arg Glu Arg Val Lys Ile Tyr Ala Asp 425 430 435 ggg att gta gat cac ttc tta acc gaa ctg gct aaa aag ttt caa cag 1459 Gly Ile Val Asp His Phe Leu Thr Glu Leu Ala Lys Lys Phe Gln Gln 440 445 450 aat taattagcct atctcggctt tcgccttccg 1492 Asn <210> 12 <211> 454 <212> PRT <213> Corynebacterium glutamicum <400> 12 Met Asn Asp Glu Asn Ile Gln Ser Ser Asn Tyr Gln Pro Phe Pro Ser 1 5 10 15 Phe Asp Asp Trp Lys Gln Ile Glu Val Ser Leu Leu Asp Val Ile Glu 20 25 30 Ser Ser Arg His Phe Ser Asp Leu Lys Asp Ser Thr Asp Arg Ser Ala 35 40 45 Leu Asp Ala Ala Leu Glu Arg Ala Lys Arg Ala Ala Ala Val Asp Thr 50 55 60 Asn Ala Ile Glu Gly Ile Phe Gln Thr Asp Arg Gly Phe Thr His Thr 65 70 75 80 Val Ala Thr Gln Val Gly Ala Trp Glu Gln Gln Met Ala Met Lys Gly 85 90 95 Lys His Val Lys Pro Ala Phe Asp Asp Thr Leu Glu Gly Phe Glu Tyr 100 105 110 Val Leu Asp Ala Val Thr Gly Arg Thr Pro Ile Ser Gln Gln Trp Ile 115 120 125 Arg Asn Leu His Ala Val Ile Leu Arg Ser Gln Glu Ser His Glu Val 130 135 140 Phe Thr Ala Val Gly Val Gln Asn Gln Ala Leu Gln Lys Gly Glu Tyr 145 150 155 160 Lys Thr Gln Pro Asn Ser Pro Gln Arg Ser Asp Gly Ser Val His Ala 165 170 175 Tyr Ala Pro Val Glu Asp Thr Pro Ala Glu Met Ala Arg Phe Ile Ser 180 185 190 Glu Leu Glu Ser Lys Glu Phe Leu Ala Ala Glu Lys Val Ile Gln Ala 195 200 205 Ala Tyr Ala His Tyr Ala Phe Val Cys Ile His Pro Phe Ala Asp Gly 210 215 220 Asn Gly Arg Val Ala Arg Ala Leu Ala Ser Val Phe Leu Tyr Lys Asp 225 230 235 240 Pro Gly Val Pro Leu Val Ile Tyr Gln Asp Gln Arg Arg Asp Tyr Ile 245 250 255 His Ala Leu Glu Ala Ala Asp Lys Asn Asn Pro Leu Leu Leu Ile Arg 260 265 270 Phe Phe Ala Glu Arg Val Thr Asp Thr Ile Asn Ser Ile Ile Val Asp 275 280 285 Leu Thr Thr Pro Ile Ala Gly Lys Ser Gly Ser Ala Lys Leu Ser Asp 290 295 300 Ala Leu Arg Pro Thr Arg Val Leu Pro Glu Leu His Asp Ala Ala His 305 310 315 320 Arg Leu Gln Glu Ser Leu Phe Thr Glu Ile Arg Ser Arg Leu Asp Glu 325 330 335 Glu Gly Lys Arg Asn Gly Leu Glu Phe Leu Leu Gln Arg Ile Phe Ile 340 345 350 Gly Ser Pro Phe Asn Leu Pro Glu Gly Tyr Asn Ala Phe Pro Asp Ser 355 360 365 Tyr Cys Leu Thr Leu Ala Phe Asn Ser Asn Ser Pro Lys Gln Ile Phe 370 375 380 His Pro Leu Ser Ile Val Ile Ala Ala Arg Asp Gly Lys Arg Ala Ser 385 390 395 400 Ser Asp Leu Val Ala Ala Thr Ser Ile Gly Tyr Asn Phe His Ala Tyr 405 410 415 Gly Arg Glu Val Glu Pro Val Val Thr Glu Ser Phe Arg Glu Arg Val 420 425 430 Lys Ile Tyr Ala Asp Gly Ile Val Asp His Phe Leu Thr Glu Leu Ala 435 440 445 Lys Lys Phe Gln Gln Asn 450 <210> 13 <211> 1660 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1630) <223> RXA00080 <400> 13 atgttcttgt ttccctcatg atgagctccg tggtctacct cgcattcgat gtgggcttgg 60 gacttaatct tccttccgga cttttgggtg gtggctttta atg gat att ttg tcc 115 Met Asp Ile Leu Ser 1 5 ctc ttg atg gaa ggt ttc gcc ggc gcg cta acg ccg atg aac ctc ctc 163 Leu Leu Met Glu Gly Phe Ala Gly Ala Leu Thr Pro Met Asn Leu Leu 10 15 20 tgg gtg att gtc ggc tgt ttg ctc ggc acc gcg gtt ggc gtc atg cct 211 Trp Val Ile Val Gly Cys Leu Leu Gly Thr Ala Val Gly Val Met Pro 25 30 35 ggt ctt gga tcc tcc atg gct gtg gcg ctg ctg ctg cca atg acc ttc 259 Gly Leu Gly Ser Ser Met Ala Val Ala Leu Leu Leu Pro Met Thr Phe 40 45 50 gcg ctt gat cca act gcc gcg ttc att atg ttc tct ggc gta tat ttc 307 Ala Leu Asp Pro Thr Ala Ala Phe Ile Met Phe Ser Gly Val Tyr Phe 55 60 65 ggt ggt ctc ttc ggt gac tcc acg atg gca att ttg atg aac acc cca 355 Gly Gly Leu Phe Gly Asp Ser Thr Met Ala Ile Leu Met Asn Thr Pro 70 75 80 85 ggt cag gca tcg gca atc gcc tca aca ttc gag ggc cac cgc atg gct 403 Gly Gln Ala Ser Ala Ile Ala Ser Thr Phe Glu Gly His Arg Met Ala 90 95 100 ctt aac ggc cgt gcg cca cag gct ctg gct acc gca gcg atc ggt gcc 451 Leu Asn Gly Arg Ala Pro Gln Ala Leu Ala Thr Ala Ala Ile Gly Ala 105 110 115 ttc atc ggc ggt atc gtc tcc tcc ttc atc gtg gtc ttc ctc gca cca 499 Phe Ile Gly Gly Ile Val Ser Ser Phe Ile Val Val Phe Leu Ala Pro 120 125 130 acc ctg gcg gaa ctg tcc acc gca ttc ggc ccc gcc gag tac ttc gca 547 Thr Leu Ala Glu Leu Ser Thr Ala Phe Gly Pro Ala Glu Tyr Phe Ala 135 140 145 ctg gca ctc ttc gcg ttc gtc gcc acc tcc tcc gtg gtg tcc gac tcc 595 Leu Ala Leu Phe Ala Phe Val Ala Thr Ser Ser Val Val Ser Asp Ser 150 155 160 165 gtg ttt aag gga ctt gcg tcc ctc att ttc ggc ctc ggc att gcg acc 643 Val Phe Lys Gly Leu Ala Ser Leu Ile Phe Gly Leu Gly Ile Ala Thr 170 175 180 atc ggc atc gat tcg gtc acc ggc atc gag cgc ttc acg ctc ggg gca 691 Ile Gly Ile Asp Ser Val Thr Gly Ile Glu Arg Phe Thr Leu Gly Ala 185 190 195 ccg cag ctt ttc gac gga att tcc ctc gtt act gtt acc gtc gcg att 739 Pro Gln Leu Phe Asp Gly Ile Ser Leu Val Thr Val Thr Val Ala Ile 200 205 210 ttg gca ctg gga gaa gtg ttt tac att gca gcc cgc gca cgc cgt gac 787 Leu Ala Leu Gly Glu Val Phe Tyr Ile Ala Ala Arg Ala Arg Arg Asp 215 220 225 aaa gca aat ctg gag acg cgc tct gca ggc cgt ccg tgg ctt acc gga 835 Lys Ala Asn Leu Glu Thr Arg Ser Ala Gly Arg Pro Trp Leu Thr Gly 230 235 240 245 acg gaa ttc aaa gaa gcc gct cca gcc tgg gca cgc gga acc atc att 883 Thr Glu Phe Lys Glu Ala Ala Pro Ala Trp Ala Arg Gly Thr Ile Ile 250 255 260 ggt ctg cct ttc ggt gtg atc cct gtt ggt gga tct gaa gtt cca acc 931 Gly Leu Pro Phe Gly Val Ile Pro Val Gly Gly Ser Glu Val Pro Thr 265 270 275 ttc ttg gct tac tcc acc gag cgc gca ttg gat aaa cga cgc aaa gat 979 Phe Leu Ala Tyr Ser Thr Glu Arg Ala Leu Asp Lys Arg Arg Lys Asp 280 285 290 ccg cag ttc ggc gat aaa ggt gca atc cga gga ctc gct gct cct gaa 1027 Pro Gln Phe Gly Asp Lys Gly Ala Ile Arg Gly Leu Ala Ala Pro Glu 295 300 305 gct gca ggt aac gcc acc aca ggc atg gcg atg ggc gct ctt ctt gcc 1075 Ala Ala Gly Asn Ala Thr Thr Gly Met Ala Met Gly Ala Leu Leu Ala 310 315 320 325 ctg ggt ctc cca gtc tct gca act gcg gcc atc atg ttg gca gcg ttc 1123 Leu Gly Leu Pro Val Ser Ala Thr Ala Ala Ile Met Leu Ala Ala Phe 330 335 340 cgc cag tac gga atc cag ccc gga cca cta ctc ttc gat cgc aac cct 1171 Arg Gln Tyr Gly Ile Gln Pro Gly Pro Leu Leu Phe Asp Arg Asn Pro 345 350 355 gaa ctt gtc tgg gca ctt ctt gcc agc ttc ttc atc gcg atg atc gtc 1219 Glu Leu Val Trp Ala Leu Leu Ala Ser Phe Phe Ile Ala Met Ile Val 360 365 370 ctg ctg ttc atc aac ctg ccg ttc gca cag ctg tgg gca aag ctc ctg 1267 Leu Leu Phe Ile Asn Leu Pro Phe Ala Gln Leu Trp Ala Lys Leu Leu 375 380 385 ctc att cca aac cac tac ctc tac tcc ggc atc gca ttg ttc tgt ggc 1315 Leu Ile Pro Asn His Tyr Leu Tyr Ser Gly Ile Ala Leu Phe Cys Gly 390 395 400 405 ctg ggc att tac gcc acc tcc ggc gca gtg ttc gac ctg ctc atg ctg 1363 Leu Gly Ile Tyr Ala Thr Ser Gly Ala Val Phe Asp Leu Leu Met Leu 410 415 420 ctc ggc atc ggt gtc gtg gct ttg atc atg cgt cgc tac ggt tac ccg 1411 Leu Gly Ile Gly Val Val Ala Leu Ile Met Arg Arg Tyr Gly Tyr Pro 425 430 435 ctg gca ccg ctg atg atc ggt atg gtt ctt gga cct ttg gct gaa acc 1459 Leu Ala Pro Leu Met Ile Gly Met Val Leu Gly Pro Leu Ala Glu Thr 440 445 450 tcc ctc cgc gac gca cta ctg tcc tcg gtt ggc gat ttc tcc atc ctc 1507 Ser Leu Arg Asp Ala Leu Leu Ser Ser Val Gly Asp Phe Ser Ile Leu 455 460 465 gtc tcc agc ccc atc acc tgg tcc ctc tac gca gtg ctc gcc atc ttc 1555 Val Ser Ser Pro Ile Thr Trp Ser Leu Tyr Ala Val Leu Ala Ile Phe 470 475 480 485 atc gcg gtc agt gtc atc act gca atc cgc ggt cgt cgc aag cac ctg 1603 Ile Ala Val Ser Val Ile Thr Ala Ile Arg Gly Arg Arg Lys His Leu 490 495 500 act tct cag ctc gaa acc atc gac gct taaagtcccc gtatagaaac 1650 Thr Ser Gln Leu Glu Thr Ile Asp Ala 505 510 aggcaaaccg 1660 <210> 14 <211> 510 <212> PRT <213> Corynebacterium glutamicum <400> 14 Met Asp Ile Leu Ser Leu Leu Met Glu Gly Phe Ala Gly Ala Leu Thr 1 5 10 15 Pro Met Asn Leu Leu Trp Val Ile Val Gly Cys Leu Leu Gly Thr Ala 20 25 30 Val Gly Val Met Pro Gly Leu Gly Ser Ser Met Ala Val Ala Leu Leu 35 40 45 Leu Pro Met Thr Phe Ala Leu Asp Pro Thr Ala Ala Phe Ile Met Phe 50 55 60 Ser Gly Val Tyr Phe Gly Gly Leu Phe Gly Asp Ser Thr Met Ala Ile 65 70 75 80 Leu Met Asn Thr Pro Gly Gln Ala Ser Ala Ile Ala Ser Thr Phe Glu 85 90 95 Gly His Arg Met Ala Leu Asn Gly Arg Ala Pro Gln Ala Leu Ala Thr 100 105 110 Ala Ala Ile Gly Ala Phe Ile Gly Gly Ile Val Ser Ser Phe Ile Val 115 120 125 Val Phe Leu Ala Pro Thr Leu Ala Glu Leu Ser Thr Ala Phe Gly Pro 130 135 140 Ala Glu Tyr Phe Ala Leu Ala Leu Phe Ala Phe Val Ala Thr Ser Ser 145 150 155 160 Val Val Ser Asp Ser Val Phe Lys Gly Leu Ala Ser Leu Ile Phe Gly 165 170 175 Leu Gly Ile Ala Thr Ile Gly Ile Asp Ser Val Thr Gly Ile Glu Arg 180 185 190 Phe Thr Leu Gly Ala Pro Gln Leu Phe Asp Gly Ile Ser Leu Val Thr 195 200 205 Val Thr Val Ala Ile Leu Ala Leu Gly Glu Val Phe Tyr Ile Ala Ala 210 215 220 Arg Ala Arg Arg Asp Lys Ala Asn Leu Glu Thr Arg Ser Ala Gly Arg 225 230 235 240 Pro Trp Leu Thr Gly Thr Glu Phe Lys Glu Ala Ala Pro Ala Trp Ala 245 250 255 Arg Gly Thr Ile Ile Gly Leu Pro Phe Gly Val Ile Pro Val Gly Gly 260 265 270 Ser Glu Val Pro Thr Phe Leu Ala Tyr Ser Thr Glu Arg Ala Leu Asp 275 280 285 Lys Arg Arg Lys Asp Pro Gln Phe Gly Asp Lys Gly Ala Ile Arg Gly 290 295 300 Leu Ala Ala Pro Glu Ala Ala Gly Asn Ala Thr Thr Gly Met Ala Met 305 310 315 320 Gly Ala Leu Leu Ala Leu Gly Leu Pro Val Ser Ala Thr Ala Ala Ile 325 330 335 Met Leu Ala Ala Phe Arg Gln Tyr Gly Ile Gln Pro Gly Pro Leu Leu 340 345 350 Phe Asp Arg Asn Pro Glu Leu Val Trp Ala Leu Leu Ala Ser Phe Phe 355 360 365 Ile Ala Met Ile Val Leu Leu Phe Ile Asn Leu Pro Phe Ala Gln Leu 370 375 380 Trp Ala Lys Leu Leu Leu Ile Pro Asn His Tyr Leu Tyr Ser Gly Ile 385 390 395 400 Ala Leu Phe Cys Gly Leu Gly Ile Tyr Ala Thr Ser Gly Ala Val Phe 405 410 415 Asp Leu Leu Met Leu Leu Gly Ile Gly Val Val Ala Leu Ile Met Arg 420 425 430 Arg Tyr Gly Tyr Pro Leu Ala Pro Leu Met Ile Gly Met Val Leu Gly 435 440 445 Pro Leu Ala Glu Thr Ser Leu Arg Asp Ala Leu Leu Ser Ser Val Gly 450 455 460 Asp Phe Ser Ile Leu Val Ser Ser Pro Ile Thr Trp Ser Leu Tyr Ala 465 470 475 480 Val Leu Ala Ile Phe Ile Ala Val Ser Val Ile Thr Ala Ile Arg Gly 485 490 495 Arg Arg Lys His Leu Thr Ser Gln Leu Glu Thr Ile Asp Ala 500 505 510 <210> 15 <211> 679 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(649) <223> RXA00110 <400> 15 atatcgaatg tccagtcacg ctaaacttca cccaagatga gatttcgtgg cacgattggg 60 aataacgaac gctaatttta aacactggag gagcttccac gtg agc aac aaa gac 115 Val Ser Asn Lys Asp 1 5 ggc ctt ttt act gac ggt aac agc acg ttt gca cct aag gtg gat tca 163 Gly Leu Phe Thr Asp Gly Asn Ser Thr Phe Ala Pro Lys Val Asp Ser 10 15 20 att ccc ctc agc gat gtg gat acc agc gtt agc ggt gaa gcc tcc atc 211 Ile Pro Leu Ser Asp Val Asp Thr Ser Val Ser Gly Glu Ala Ser Ile 25 30 35 ggc acg ctg atc tcc aac gca acc tcc caa atg tcc agc ctt ttc cgc 259 Gly Thr Leu Ile Ser Asn Ala Thr Ser Gln Met Ser Ser Leu Phe Arg 40 45 50 gca gaa gtt gag ctg gcg aag act gaa ctc gca ggc gaa gcc aag aaa 307 Ala Glu Val Glu Leu Ala Lys Thr Glu Leu Ala Gly Glu Ala Lys Lys 55 60 65 gct gcc atc ggc ggc ggc gca ttc agc gtt gct ggc gta atc gca ctg 355 Ala Ala Ile Gly Gly Gly Ala Phe Ser Val Ala Gly Val Ile Ala Leu 70 75 80 85 tac agc tcc ttc ttc ttt ttc ttc ttc gtc gca gca ctg ctg agc gag 403 Tyr Ser Ser Phe Phe Phe Phe Phe Phe Val Ala Ala Leu Leu Ser Glu 90 95 100 tgg att aag cct tgg gca gca ttc ctc atc gtg ttc ctc ttc atg ctg 451 Trp Ile Lys Pro Trp Ala Ala Phe Leu Ile Val Phe Leu Phe Met Leu 105 110 115 gtc atc gcc gca gct ctc gca ctg ttc ggc tgg cgc aag gtg aag aag 499 Val Ile Ala Ala Ala Leu Ala Leu Phe Gly Trp Arg Lys Val Lys Lys 120 125 130 atg ggc gct ccg aag aac acc atc caa tcg gtc aac caa ctg aag aac 547 Met Gly Ala Pro Lys Asn Thr Ile Gln Ser Val Asn Gln Leu Lys Asn 135 140 145 ctg gtc cca ggt cag gca tcc gag aag ctg gag aag gcc aac aag cgt 595 Leu Val Pro Gly Gln Ala Ser Glu Lys Leu Glu Lys Ala Asn Lys Arg 150 155 160 165 ggc ctc tac acc tcc gcg tcc ttc cac agc ccc ggc gcc atc act ggc 643 Gly Leu Tyr Thr Ser Ala Ser Phe His Ser Pro Gly Ala Ile Thr Gly 170 175 180 gac cac taaaaaagga gacttcgatg gcctttttta 679 Asp His <210> 16 <211> 183 <212> PRT <213> Corynebacterium glutamicum <400> 16 Val Ser Asn Lys Asp Gly Leu Phe Thr Asp Gly Asn Ser Thr Phe Ala 1 5 10 15 Pro Lys Val Asp Ser Ile Pro Leu Ser Asp Val Asp Thr Ser Val Ser 20 25 30 Gly Glu Ala Ser Ile Gly Thr Leu Ile Ser Asn Ala Thr Ser Gln Met 35 40 45 Ser Ser Leu Phe Arg Ala Glu Val Glu Leu Ala Lys Thr Glu Leu Ala 50 55 60 Gly Glu Ala Lys Lys Ala Ala Ile Gly Gly Gly Ala Phe Ser Val Ala 65 70 75 80 Gly Val Ile Ala Leu Tyr Ser Ser Phe Phe Phe Phe Phe Phe Val Ala 85 90 95 Ala Leu Leu Ser Glu Trp Ile Lys Pro Trp Ala Ala Phe Leu Ile Val 100 105 110 Phe Leu Phe Met Leu Val Ile Ala Ala Ala Leu Ala Leu Phe Gly Trp 115 120 125 Arg Lys Val Lys Lys Met Gly Ala Pro Lys Asn Thr Ile Gln Ser Val 130 135 140 Asn Gln Leu Lys Asn Leu Val Pro Gly Gln Ala Ser Glu Lys Leu Glu 145 150 155 160 Lys Ala Asn Lys Arg Gly Leu Tyr Thr Ser Ala Ser Phe His Ser Pro 165 170 175 Gly Ala Ile Thr Gly Asp His 180 <210> 17 <211> 469 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(439) <223> RXA00118 <400> 17 cgatccacga ttttagagtc tgtgcatcta cggaagtaat cggttgagcg gaagtcatac 60 cttgtccttt tcaatctcaa agtgatgggc gattccaagt gtg cca tat acc ctg 115 Val Pro Tyr Thr Leu 1 5 ggg ggt att caa gat agg ggt ggg ggt ata ctg tgg gat caa cgt tcc 163 Gly Gly Ile Gln Asp Arg Gly Gly Gly Ile Leu Trp Asp Gln Arg Ser 10 15 20 agg gca aca aaa gga gaa aaa atg caa ctc aat cct gat gag atc acc 211 Arg Ala Thr Lys Gly Glu Lys Met Gln Leu Asn Pro Asp Glu Ile Thr 25 30 35 cca gtg ctc aac cga ctc aag cgc gcc caa ggt caa ctc acc gga gta 259 Pro Val Leu Asn Arg Leu Lys Arg Ala Gln Gly Gln Leu Thr Gly Val 40 45 50 atc cga atg ctt gat gaa ggc gaa gac tgt aaa gcc gta gtc acc caa 307 Ile Arg Met Leu Asp Glu Gly Glu Asp Cys Lys Ala Val Val Thr Gln 55 60 65 ctt gcc gca gtc aca aaa gcg ctg gac agg gca ggc ttc gcc atc att 355 Leu Ala Ala Val Thr Lys Ala Leu Asp Arg Ala Gly Phe Ala Ile Ile 70 75 80 85 gcc aca ggt ttg gaa cag tgc ctc acc aac cct gat ggc gac atg gac 403 Ala Thr Gly Leu Glu Gln Cys Leu Thr Asn Pro Asp Gly Asp Met Asp 90 95 100 aaa aag gaa cta gaa aaa ctg ttc ctg tcg ctg gct taactatggc 449 Lys Lys Glu Leu Glu Lys Leu Phe Leu Ser Leu Ala 105 110 ctagttcagg gcgtttgggt 469 <210> 18 <211> 113 <212> PRT <213> Corynebacterium glutamicum <400> 18 Val Pro Tyr Thr Leu Gly Gly Ile Gln Asp Arg Gly Gly Gly Ile Leu 1 5 10 15 Trp Asp Gln Arg Ser Arg Ala Thr Lys Gly Glu Lys Met Gln Leu Asn 20 25 30 Pro Asp Glu Ile Thr Pro Val Leu Asn Arg Leu Lys Arg Ala Gln Gly 35 40 45 Gln Leu Thr Gly Val Ile Arg Met Leu Asp Glu Gly Glu Asp Cys Lys 50 55 60 Ala Val Val Thr Gln Leu Ala Ala Val Thr Lys Ala Leu Asp Arg Ala 65 70 75 80 Gly Phe Ala Ile Ile Ala Thr Gly Leu Glu Gln Cys Leu Thr Asn Pro 85 90 95 Asp Gly Asp Met Asp Lys Lys Glu Leu Glu Lys Leu Phe Leu Ser Leu 100 105 110 Ala <210> 19 <211> 841 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(811) <223> RXA00121 <400> 19 gatgtccaaa tactgcgaaa ccatcgaagc gtttcacaac cgtccggcat cagctttcgg 60 cgctgtcgac cccatcttct aaacaagaaa ggcccctcca atg ttg agc gat ctg 115 Met Leu Ser Asp Leu 1 5 agc tcc att ttt gac ttc caa gac ctc tcc ggc acc ttc tct gtc gtc 163 Ser Ser Ile Phe Asp Phe Gln Asp Leu Ser Gly Thr Phe Ser Val Val 10 15 20 gac gtt ctc atc act ttg gtc ttg tcc ttc gtc ctg acc tcc atc gtg 211 Asp Val Leu Ile Thr Leu Val Leu Ser Phe Val Leu Thr Ser Ile Val 25 30 35 ggt gtg gtg tac caa aag acc cac cgc cac atc tcc tac agc cag tca 259 Gly Val Val Tyr Gln Lys Thr His Arg His Ile Ser Tyr Ser Gln Ser 40 45 50 ttc gta caa acg ttg gtg ctg gtg gga atg gtc att gca atc atc atg 307 Phe Val Gln Thr Leu Val Leu Val Gly Met Val Ile Ala Ile Ile Met 55 60 65 ctg gtg gtc ggc tcc aac att gca cgt gca ttc gcc ctg gtt ggc gcg 355 Leu Val Val Gly Ser Asn Ile Ala Arg Ala Phe Ala Leu Val Gly Ala 70 75 80 85 ctt tcg gtg att cga ttc cgc aac gca gtg aaa gaa acc cga gat gtg 403 Leu Ser Val Ile Arg Phe Arg Asn Ala Val Lys Glu Thr Arg Asp Val 90 95 100 ggc ttc ctt ttc ctt gcc atg gca atc ggc atg act tgc ggt acc cgc 451 Gly Phe Leu Phe Leu Ala Met Ala Ile Gly Met Thr Cys Gly Thr Arg 105 110 115 ttc tac gtt ctg gcg atc gct gca acc atc gtt gtc tgt ggc gtt ctg 499 Phe Tyr Val Leu Ala Ile Ala Ala Thr Ile Val Val Cys Gly Val Leu 120 125 130 ttc atc atg tac cgc ttc gac tgg ttc aag gct gat atc cag cgc cag 547 Phe Ile Met Tyr Arg Phe Asp Trp Phe Lys Ala Asp Ile Gln Arg Gln 135 140 145 gtc atc aag gtg cag gtc cca gcc gat gga caa gct gat tcc ggc agg 595 Val Ile Lys Val Gln Val Pro Ala Asp Gly Gln Ala Asp Ser Gly Arg 150 155 160 165 tcc tac gca gaa gaa gtt gaa ctg atc ctc gca cag tac tgc act tcc 643 Ser Tyr Ala Glu Glu Val Glu Leu Ile Leu Ala Gln Tyr Cys Thr Ser 170 175 180 ttt gag atg atg tcc gct gaa tct gtc cgc ggc gga gcc ctg acc gag 691 Phe Glu Met Met Ser Ala Glu Ser Val Arg Gly Gly Ala Leu Thr Glu 185 190 195 ttc tcc tac acc gct caa atg cgc aag aac gtg aag cca cat gag ctg 739 Phe Ser Tyr Thr Ala Gln Met Arg Lys Asn Val Lys Pro His Glu Leu 200 205 210 gtc gcc aag atg cgc gat gtg aac tac ggc caa aaa gcg act gtc ctg 787 Val Ala Lys Met Arg Asp Val Asn Tyr Gly Gln Lys Ala Thr Val Leu 215 220 225 acc ggt cac gat caa acg gat gta tagaaaatgc ctagctttaa atctgctcga 841 Thr Gly His Asp Gln Thr Asp Val 230 235 <210> 20 <211> 237 <212> PRT <213> Corynebacterium glutamicum <400> 20 Met Leu Ser Asp Leu Ser Ser Ile Phe Asp Phe Gln Asp Leu Ser Gly 1 5 10 15 Thr Phe Ser Val Val Asp Val Leu Ile Thr Leu Val Leu Ser Phe Val 20 25 30 Leu Thr Ser Ile Val Gly Val Val Tyr Gln Lys Thr His Arg His Ile 35 40 45 Ser Tyr Ser Gln Ser Phe Val Gln Thr Leu Val Leu Val Gly Met Val 50 55 60 Ile Ala Ile Ile Met Leu Val Val Gly Ser Asn Ile Ala Arg Ala Phe 65 70 75 80 Ala Leu Val Gly Ala Leu Ser Val Ile Arg Phe Arg Asn Ala Val Lys 85 90 95 Glu Thr Arg Asp Val Gly Phe Leu Phe Leu Ala Met Ala Ile Gly Met 100 105 110 Thr Cys Gly Thr Arg Phe Tyr Val Leu Ala Ile Ala Ala Thr Ile Val 115 120 125 Val Cys Gly Val Leu Phe Ile Met Tyr Arg Phe Asp Trp Phe Lys Ala 130 135 140 Asp Ile Gln Arg Gln Val Ile Lys Val Gln Val Pro Ala Asp Gly Gln 145 150 155 160 Ala Asp Ser Gly Arg Ser Tyr Ala Glu Glu Val Glu Leu Ile Leu Ala 165 170 175 Gln Tyr Cys Thr Ser Phe Glu Met Met Ser Ala Glu Ser Val Arg Gly 180 185 190 Gly Ala Leu Thr Glu Phe Ser Tyr Thr Ala Gln Met Arg Lys Asn Val 195 200 205 Lys Pro His Glu Leu Val Ala Lys Met Arg Asp Val Asn Tyr Gly Gln 210 215 220 Lys Ala Thr Val Leu Thr Gly His Asp Gln Thr Asp Val 225 230 235 <210> 21 <211> 904 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(874) <223> RXA00150 <400> 21 agctgagcag ggatcggcac tagcttctac tacgataacg agaactttgt ttcaatacat 60 tcaaaatggc ggaatatttt gatcacgggg gtgcaactgt atg gtg ttt tct atg 115 Met Val Phe Ser Met 1 5 cat gac aaa ggt gag acc cag gag aat cct gcg gac atg tca gga cgc 163 His Asp Lys Gly Glu Thr Gln Glu Asn Pro Ala Asp Met Ser Gly Arg 10 15 20 cta aac aca cca att tcc acg gtc ttt cac ttc ttt agc tca ctt ttc 211 Leu Asn Thr Pro Ile Ser Thr Val Phe His Phe Phe Ser Ser Leu Phe 25 30 35 cat gac gct ctg cgc agt gtt gcc cag tgg agt gcg tgg aag aaa atc 259 His Asp Ala Leu Arg Ser Val Ala Gln Trp Ser Ala Trp Lys Lys Ile 40 45 50 gct gta tcg gtt gtc atc gtc gca att att tcc gta act ttt ctt gtc 307 Ala Val Ser Val Val Ile Val Ala Ile Ile Ser Val Thr Phe Leu Val 55 60 65 gat gtc ccc ccg att tcg gtt tat cgt gac tgg gca aac aac gcc ggc 355 Asp Val Pro Pro Ile Ser Val Tyr Arg Asp Trp Ala Asn Asn Ala Gly 70 75 80 85 gac gct ttt gtc tta gtt ttt tgc gcc ttt tat atc ctc att act cag 403 Asp Ala Phe Val Leu Val Phe Cys Ala Phe Tyr Ile Leu Ile Thr Gln 90 95 100 ttc cct atc ccc cgc aca gtt ctc aca ctg gcc tcc ggc gtg ctg ttc 451 Phe Pro Ile Pro Arg Thr Val Leu Thr Leu Ala Ser Gly Val Leu Phe 105 110 115 ggg ccg gtt ctt gga tca gtc gtg gcg ctg ggt tcc acc aca gtg tca 499 Gly Pro Val Leu Gly Ser Val Val Ala Leu Gly Ser Thr Thr Val Ser 120 125 130 gcg gta atc tcg ctc ctc att gtt cgg ggt ctg ctt ggc gat tgg atg 547 Ala Val Ile Ser Leu Leu Ile Val Arg Gly Leu Leu Gly Asp Trp Met 135 140 145 gcg cca cgt tta acg cac ccc gca gtc tca cgc atc aat acc cga ctt 595 Ala Pro Arg Leu Thr His Pro Ala Val Ser Arg Ile Asn Thr Arg Leu 150 155 160 165 gag caa cgt gga tgg ctg gcg att acc tct tta aga atg atc gcc gct 643 Glu Gln Arg Gly Trp Leu Ala Ile Thr Ser Leu Arg Met Ile Ala Ala 170 175 180 atc ccc ttt tcc atc ctc aac tat gtt gca gcc ttg act agc gtt cct 691 Ile Pro Phe Ser Ile Leu Asn Tyr Val Ala Ala Leu Thr Ser Val Pro 185 190 195 gtt ttt tct ttt gcc atc gct acc ttg atc gga tct gca cca gga acc 739 Val Phe Ser Phe Ala Ile Ala Thr Leu Ile Gly Ser Ala Pro Gly Thr 200 205 210 atc gtc acc gtc gtt ttg gga gat gca gtc aca ggt tct gga aac tgg 787 Ile Val Thr Val Val Leu Gly Asp Ala Val Thr Gly Ser Gly Asn Trp 215 220 225 act gcc gtt gca ttc acg gta ttt tta gcg att ttg ggt gtt tta ggt 835 Thr Ala Val Ala Phe Thr Val Phe Leu Ala Ile Leu Gly Val Leu Gly 230 235 240 245 atc ttt tta gat caa aag atg cca gtc aag cct gga aag tagacaatat 884 Ile Phe Leu Asp Gln Lys Met Pro Val Lys Pro Gly Lys 250 255 aaggtagggt tggagaagat 904 <210> 22 <211> 258 <212> PRT <213> Corynebacterium glutamicum <400> 22 Met Val Phe Ser Met His Asp Lys Gly Glu Thr Gln Glu Asn Pro Ala 1 5 10 15 Asp Met Ser Gly Arg Leu Asn Thr Pro Ile Ser Thr Val Phe His Phe 20 25 30 Phe Ser Ser Leu Phe His Asp Ala Leu Arg Ser Val Ala Gln Trp Ser 35 40 45 Ala Trp Lys Lys Ile Ala Val Ser Val Val Ile Val Ala Ile Ile Ser 50 55 60 Val Thr Phe Leu Val Asp Val Pro Pro Ile Ser Val Tyr Arg Asp Trp 65 70 75 80 Ala Asn Asn Ala Gly Asp Ala Phe Val Leu Val Phe Cys Ala Phe Tyr 85 90 95 Ile Leu Ile Thr Gln Phe Pro Ile Pro Arg Thr Val Leu Thr Leu Ala 100 105 110 Ser Gly Val Leu Phe Gly Pro Val Leu Gly Ser Val Val Ala Leu Gly 115 120 125 Ser Thr Thr Val Ser Ala Val Ile Ser Leu Leu Ile Val Arg Gly Leu 130 135 140 Leu Gly Asp Trp Met Ala Pro Arg Leu Thr His Pro Ala Val Ser Arg 145 150 155 160 Ile Asn Thr Arg Leu Glu Gln Arg Gly Trp Leu Ala Ile Thr Ser Leu 165 170 175 Arg Met Ile Ala Ala Ile Pro Phe Ser Ile Leu Asn Tyr Val Ala Ala 180 185 190 Leu Thr Ser Val Pro Val Phe Ser Phe Ala Ile Ala Thr Leu Ile Gly 195 200 205 Ser Ala Pro Gly Thr Ile Val Thr Val Val Leu Gly Asp Ala Val Thr 210 215 220 Gly Ser Gly Asn Trp Thr Ala Val Ala Phe Thr Val Phe Leu Ala Ile 225 230 235 240 Leu Gly Val Leu Gly Ile Phe Leu Asp Gln Lys Met Pro Val Lys Pro 245 250 255 Gly Lys <210> 23 <211> 727 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(697) <223> RXA00151 <400> 23 aagtagacaa tataaggtag ggttggagaa gattctttac ttcttcactc attcgccctg 60 acagcgaatc cactacaata aacaaagggg gcagccaccc atg tgg gca ctg cat 115 Met Trp Ala Leu His 1 5 gcc aga tac cgc ggc cga gac aca cga cga gcc gaa ttg gtt aaa aga 163 Ala Arg Tyr Arg Gly Arg Asp Thr Arg Arg Ala Glu Leu Val Lys Arg 10 15 20 ttt gca gaa gct ttg tcc acc ctc gaa ggt gct ggc cag ttt gaa gtc 211 Phe Ala Glu Ala Leu Ser Thr Leu Glu Gly Ala Gly Gln Phe Glu Val 25 30 35 att ggt gtc gaa gac atc cga gca cac atc acc tca ccg tta acc aca 259 Ile Gly Val Glu Asp Ile Arg Ala His Ile Thr Ser Pro Leu Thr Thr 40 45 50 tgt gat gtt gtc atg gcg cta ctc gca gct ggc gat tgg gca atc gga 307 Cys Asp Val Val Met Ala Leu Leu Ala Ala Gly Asp Trp Ala Ile Gly 55 60 65 att ggt gtt atc ccc acc gtt gac gga aca gtc gat gaa tcg gat gag 355 Ile Gly Val Ile Pro Thr Val Asp Gly Thr Val Asp Glu Ser Asp Glu 70 75 80 85 gcc atc atc gaa cag gta aag aaa att tcc tct gat gct ctg cgc ccc 403 Ala Ile Ile Glu Gln Val Lys Lys Ile Ser Ser Asp Ala Leu Arg Pro 90 95 100 acc gcc aag gcg gga acg gtc aaa gtt agg atc gcc gga acc aaa cgg 451 Thr Ala Lys Ala Gly Thr Val Lys Val Arg Ile Ala Gly Thr Lys Arg 105 110 115 gac aat act caa gcc ttc aac atc tcc gct gca ttc acg ttg att ggg 499 Asp Asn Thr Gln Ala Phe Asn Ile Ser Ala Ala Phe Thr Leu Ile Gly 120 125 130 caa gtt ctg tca aag cgc acc atc gaa gga cgc gaa gcc acc gca ctc 547 Gln Val Leu Ser Lys Arg Thr Ile Glu Gly Arg Glu Ala Thr Ala Leu 135 140 145 gtc cgt tct gga ctg aat caa aat gag gca gcc caa gag ctc ggt att 595 Val Arg Ser Gly Leu Asn Gln Asn Glu Ala Ala Gln Glu Leu Gly Ile 150 155 160 165 tcc aag cag gca atg tcg cag cga ttg cag gcg gca ggt tgg cag gcg 643 Ser Lys Gln Ala Met Ser Gln Arg Leu Gln Ala Ala Gly Trp Gln Ala 170 175 180 gaa tct gct ggt tgg caa ttg gcc gta aac ctc atc gag cag gct ggc 691 Glu Ser Ala Gly Trp Gln Leu Ala Val Asn Leu Ile Glu Gln Ala Gly 185 190 195 aag cgc tagcaggcga tttaagagcc tgagtttgtg 727 Lys Arg <210> 24 <211> 199 <212> PRT <213> Corynebacterium glutamicum <400> 24 Met Trp Ala Leu His Ala Arg Tyr Arg Gly Arg Asp Thr Arg Arg Ala 1 5 10 15 Glu Leu Val Lys Arg Phe Ala Glu Ala Leu Ser Thr Leu Glu Gly Ala 20 25 30 Gly Gln Phe Glu Val Ile Gly Val Glu Asp Ile Arg Ala His Ile Thr 35 40 45 Ser Pro Leu Thr Thr Cys Asp Val Val Met Ala Leu Leu Ala Ala Gly 50 55 60 Asp Trp Ala Ile Gly Ile Gly Val Ile Pro Thr Val Asp Gly Thr Val 65 70 75 80 Asp Glu Ser Asp Glu Ala Ile Ile Glu Gln Val Lys Lys Ile Ser Ser 85 90 95 Asp Ala Leu Arg Pro Thr Ala Lys Ala Gly Thr Val Lys Val Arg Ile 100 105 110 Ala Gly Thr Lys Arg Asp Asn Thr Gln Ala Phe Asn Ile Ser Ala Ala 115 120 125 Phe Thr Leu Ile Gly Gln Val Leu Ser Lys Arg Thr Ile Glu Gly Arg 130 135 140 Glu Ala Thr Ala Leu Val Arg Ser Gly Leu Asn Gln Asn Glu Ala Ala 145 150 155 160 Gln Glu Leu Gly Ile Ser Lys Gln Ala Met Ser Gln Arg Leu Gln Ala 165 170 175 Ala Gly Trp Gln Ala Glu Ser Ala Gly Trp Gln Leu Ala Val Asn Leu 180 185 190 Ile Glu Gln Ala Gly Lys Arg 195 <210> 25 <211> 913 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(883) <223> RXA00155 <400> 25 gttgcgggag tgtccaccaa aaatattgcc tgcatagggg tctgaaaaac tcatagctca 60 ccaccctagt caaagcactg cactacactt ccctaacact atg gaa att cga gca 115 Met Glu Ile Arg Ala 1 5 aac gtt tat tca ccg ctt caa aat act gcc gtc tgg cta ggt gcg tgg 163 Asn Val Tyr Ser Pro Leu Gln Asn Thr Ala Val Trp Leu Gly Ala Trp 10 15 20 ctc tat gaa tta gtg ccc acc gaa gat gtc atc gat gcg ttc gtc gat 211 Leu Tyr Glu Leu Val Pro Thr Glu Asp Val Ile Asp Ala Phe Val Asp 25 30 35 ctc ggc ggc ccg cac acc ttc ggc gac ggc ggg ctg ctc gat atg ctg 259 Leu Gly Gly Pro His Thr Phe Gly Asp Gly Gly Leu Leu Asp Met Leu 40 45 50 cga act tta aaa gaa tta aca agc acg ctt atc gac gcc ccc ttc cac 307 Arg Thr Leu Lys Glu Leu Thr Ser Thr Leu Ile Asp Ala Pro Phe His 55 60 65 ggt ccg att tta act ctc gca ctc agc ggc cca ggc caa gtg ccg gcg 355 Gly Pro Ile Leu Thr Leu Ala Leu Ser Gly Pro Gly Gln Val Pro Ala 70 75 80 85 ttg ccg gca ggt tca cgc gct gcg gtc ttg gcc tcc gcc tcg aag gag 403 Leu Pro Ala Gly Ser Arg Ala Ala Val Leu Ala Ser Ala Ser Lys Glu 90 95 100 ggg gcg ttg gtg ctg ggc ggc gtc gat aag cag cat tct tgg gcg ctt 451 Gly Ala Leu Val Leu Gly Gly Val Asp Lys Gln His Ser Trp Ala Leu 105 110 115 att cct acg cgc ggt aag gat gcc act gag tgg aat ttg gtg gag gtg 499 Ile Pro Thr Arg Gly Lys Asp Ala Thr Glu Trp Asn Leu Val Glu Val 120 125 130 gag ggc ttt ttg ccg gcg att gcg act gtc tcg ccc ggt gag gcg gat 547 Glu Gly Phe Leu Pro Ala Ile Ala Thr Val Ser Pro Gly Glu Ala Asp 135 140 145 cag ctg ctc cgt cag gcg aca gat cag gcg gca aat atc att gag tta 595 Gln Leu Leu Arg Gln Ala Thr Asp Gln Ala Ala Asn Ile Ile Glu Leu 150 155 160 165 agt ggc tac gct tca ctt gcg ccg aaa tct ttg aag aat ccg cga cta 643 Ser Gly Tyr Ala Ser Leu Ala Pro Lys Ser Leu Lys Asn Pro Arg Leu 170 175 180 acc gtg ggc atg ctg tca gat ttt tac gac acc ccg ggg ctt ccc tat 691 Thr Val Gly Met Leu Ser Asp Phe Tyr Asp Thr Pro Gly Leu Pro Tyr 185 190 195 gca gtc cca gag agg tcg gcg aag ctt ttt gcg cgc gca gat cgc gtg 739 Ala Val Pro Glu Arg Ser Ala Lys Leu Phe Ala Arg Ala Asp Arg Val 200 205 210 gct gcc atc gca gag acc gtg cag gaa acc atc ggc gat cac agc ctg 787 Ala Ala Ile Ala Glu Thr Val Gln Glu Thr Ile Gly Asp His Ser Leu 215 220 225 gat cca cag ttg att ttc ctg tgg agc cat att cgg acc gcg cgc atg 835 Asp Pro Gln Leu Ile Phe Leu Trp Ser His Ile Arg Thr Ala Arg Met 230 235 240 245 gct ggg gtg agt tat gcc ctc gca gag ttt gcg agg gac tat cac tcc 883 Ala Gly Val Ser Tyr Ala Leu Ala Glu Phe Ala Arg Asp Tyr His Ser 250 255 260 tagttggcag ctggcgccgc tgagcgagcg 913 <210> 26 <211> 261 <212> PRT <213> Corynebacterium glutamicum <400> 26 Met Glu Ile Arg Ala Asn Val Tyr Ser Pro Leu Gln Asn Thr Ala Val 1 5 10 15 Trp Leu Gly Ala Trp Leu Tyr Glu Leu Val Pro Thr Glu Asp Val Ile 20 25 30 Asp Ala Phe Val Asp Leu Gly Gly Pro His Thr Phe Gly Asp Gly Gly 35 40 45 Leu Leu Asp Met Leu Arg Thr Leu Lys Glu Leu Thr Ser Thr Leu Ile 50 55 60 Asp Ala Pro Phe His Gly Pro Ile Leu Thr Leu Ala Leu Ser Gly Pro 65 70 75 80 Gly Gln Val Pro Ala Leu Pro Ala Gly Ser Arg Ala Ala Val Leu Ala 85 90 95 Ser Ala Ser Lys Glu Gly Ala Leu Val Leu Gly Gly Val Asp Lys Gln 100 105 110 His Ser Trp Ala Leu Ile Pro Thr Arg Gly Lys Asp Ala Thr Glu Trp 115 120 125 Asn Leu Val Glu Val Glu Gly Phe Leu Pro Ala Ile Ala Thr Val Ser 130 135 140 Pro Gly Glu Ala Asp Gln Leu Leu Arg Gln Ala Thr Asp Gln Ala Ala 145 150 155 160 Asn Ile Ile Glu Leu Ser Gly Tyr Ala Ser Leu Ala Pro Lys Ser Leu 165 170 175 Lys Asn Pro Arg Leu Thr Val Gly Met Leu Ser Asp Phe Tyr Asp Thr 180 185 190 Pro Gly Leu Pro Tyr Ala Val Pro Glu Arg Ser Ala Lys Leu Phe Ala 195 200 205 Arg Ala Asp Arg Val Ala Ala Ile Ala Glu Thr Val Gln Glu Thr Ile 210 215 220 Gly Asp His Ser Leu Asp Pro Gln Leu Ile Phe Leu Trp Ser His Ile 225 230 235 240 Arg Thr Ala Arg Met Ala Gly Val Ser Tyr Ala Leu Ala Glu Phe Ala 245 250 255 Arg Asp Tyr His Ser 260 <210> 27 <211> 2758 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2728) <223> RXA00185 <400> 27 attgcgagag ctcgctgact ctgtggtcaa tggtgcagcg ccggaagaag accgcgatgc 60 gctcaaccta ttgttccgac taagccggga ggtctaagac atg cgt att cat gaa 115 Met Arg Ile His Glu 1 5 atc atc att gac aat ttc cga gcc atc gaa cat cta gaa ctt cgt gac 163 Ile Ile Ile Asp Asn Phe Arg Ala Ile Glu His Leu Glu Leu Arg Asp 10 15 20 att cct gac cag ggc gtt atc gtg atc cac ggt gac aat gag caa ggc 211 Ile Pro Asp Gln Gly Val Ile Val Ile His Gly Asp Asn Glu Gln Gly 25 30 35 aaa tct tca atc ctt gaa gcc ata aaa aca gtt ctg aat agt aaa cac 259 Lys Ser Ser Ile Leu Glu Ala Ile Lys Thr Val Leu Asn Ser Lys His 40 45 50 aga acc acc agc aag acg atc aag gcc att cag cct gtt gac cgt gat 307 Arg Thr Thr Ser Lys Thr Ile Lys Ala Ile Gln Pro Val Asp Arg Asp 55 60 65 gtt ccc atc agc atc acc ctc gag gca acc gta ggc acg gtt cga ttc 355 Val Pro Ile Ser Ile Thr Leu Glu Ala Thr Val Gly Thr Val Arg Phe 70 75 80 85 cgc ata cac aaa cgc ttc cta aaa tcc aca gcc gca gaa ctg caa gtc 403 Arg Ile His Lys Arg Phe Leu Lys Ser Thr Ala Ala Glu Leu Gln Val 90 95 100 atc gag cca cgt cca tcc aac cac cgt gga cta gaa gcc gaa gct gca 451 Ile Glu Pro Arg Pro Ser Asn His Arg Gly Leu Glu Ala Glu Ala Ala 105 110 115 ctg gca gaa ata ctg gaa agc cat ttg gac acc tct ttg ctt gac gca 499 Leu Ala Glu Ile Leu Glu Ser His Leu Asp Thr Ser Leu Leu Asp Ala 120 125 130 ttg ttt atg aaa cag ggt gaa gta gaa gca ggt atc agc gct gta gga 547 Leu Phe Met Lys Gln Gly Glu Val Glu Ala Gly Ile Ser Ala Val Gly 135 140 145 att cct acc ctg acc agc gct ttg aac gct caa aat ggc aat acc gaa 595 Ile Pro Thr Leu Thr Ser Ala Leu Asn Ala Gln Asn Gly Asn Thr Glu 150 155 160 165 gat gcc acc gaa gac acc gca ctc atg gag gct gta gaa aag gaa tac 643 Asp Ala Thr Glu Asp Thr Ala Leu Met Glu Ala Val Glu Lys Glu Tyr 170 175 180 cta aag ttc tac acc aac tcc gga aag gcg aat acg agg ttc cta cag 691 Leu Lys Phe Tyr Thr Asn Ser Gly Lys Ala Asn Thr Arg Phe Leu Gln 185 190 195 ttt tcc aaa cag gtg gaa acc ctt cgt act gat ttg gat gag gct aac 739 Phe Ser Lys Gln Val Glu Thr Leu Arg Thr Asp Leu Asp Glu Ala Asn 200 205 210 gct gaa gta gca aag ctc tcc tcc cat gtt gac cga gtt aaa cga ttg 787 Ala Glu Val Ala Lys Leu Ser Ser His Val Asp Arg Val Lys Arg Leu 215 220 225 gaa att gat cgg gat cag gcc aca gca cag tta ccc aag gca gag gaa 835 Glu Ile Asp Arg Asp Gln Ala Thr Ala Gln Leu Pro Lys Ala Glu Glu 230 235 240 245 gaa ctc gca ggg agg aaa gca gaa ctg gag gaa gcc caa aag gtt aag 883 Glu Leu Ala Gly Arg Lys Ala Glu Leu Glu Glu Ala Gln Lys Val Lys 250 255 260 gct caa gcc acg gaa atc ctt gcg cag ttt tcc cgg gcg gaa gaa cag 931 Ala Gln Ala Thr Glu Ile Leu Ala Gln Phe Ser Arg Ala Glu Glu Gln 265 270 275 tta gag cag gca aca gga gct cag aaa cga cgt aaa gaa ctc cgc aat 979 Leu Glu Gln Ala Thr Gly Ala Gln Lys Arg Arg Lys Glu Leu Arg Asn 280 285 290 aag ctg gaa tta gca cag aca gaa gtc gaa aag gct gaa gca ggg caa 1027 Lys Leu Glu Leu Ala Gln Thr Glu Val Glu Lys Ala Glu Ala Gly Gln 295 300 305 gag aac ctg gcg caa gaa gct tcc cgt gaa gca gaa gaa ttc cta gcc 1075 Glu Asn Leu Ala Gln Glu Ala Ser Arg Glu Ala Glu Glu Phe Leu Ala 310 315 320 325 tta agt gaa aag ttc gag gca gcg cgc gca gct gaa act ctg gcc gtt 1123 Leu Ser Glu Lys Phe Glu Ala Ala Arg Ala Ala Glu Thr Leu Ala Val 330 335 340 gaa aag gtg aaa gca gca cgt caa tcg gtt gct gga atc aaa aac cgt 1171 Glu Lys Val Lys Ala Ala Arg Gln Ser Val Ala Gly Ile Lys Asn Arg 345 350 355 gac cgt aaa gaa cac ctc acg gtt atg ctt ggt gaa ctt gat cga att 1219 Asp Arg Lys Glu His Leu Thr Val Met Leu Gly Glu Leu Asp Arg Ile 360 365 370 ggg cag cgc ctc tac gaa ttg cgc agc gtc cag cac tca tcg gtg cgt 1267 Gly Gln Arg Leu Tyr Glu Leu Arg Ser Val Gln His Ser Ser Val Arg 375 380 385 gtg agc cag cgt gat att gat gct ctg caa aag gcg atc acc gag gtc 1315 Val Ser Gln Arg Asp Ile Asp Ala Leu Gln Lys Ala Ile Thr Glu Val 390 395 400 405 gat atc caa agg acg ctc gtt gaa gcg cag cag gga agt att acc ctc 1363 Asp Ile Gln Arg Thr Leu Val Glu Ala Gln Gln Gly Ser Ile Thr Leu 410 415 420 agt gct tcc aca ccc acc gac att caa cta ggt gat gac acc gtt tca 1411 Ser Ala Ser Thr Pro Thr Asp Ile Gln Leu Gly Asp Asp Thr Val Ser 425 430 435 gct acc gac gct gga acc aca gtt gcc ctc gac cga gaa ctc acc gtc 1459 Ala Thr Asp Ala Gly Thr Thr Val Ala Leu Asp Arg Glu Leu Thr Val 440 445 450 gtg gtc ggc gat gtc acc ttg gtg att aac cca gga aaa aca gca gcg 1507 Val Val Gly Asp Val Thr Leu Val Ile Asn Pro Gly Lys Thr Ala Ala 455 460 465 gaa agt cgc acc gat ttt gaa tcc gcc gag gca gca ttg gcg gag ctg 1555 Glu Ser Arg Thr Asp Phe Glu Ser Ala Glu Ala Ala Leu Ala Glu Leu 470 475 480 485 ctt gat caa ctc gac gtc tca gac ttg gac cag ctc agg gaa cgt ttc 1603 Leu Asp Gln Leu Asp Val Ser Asp Leu Asp Gln Leu Arg Glu Arg Phe 490 495 500 act gcc caa gag caa cga gac gcg gat att gca gaa ctg gtt cgc gaa 1651 Thr Ala Gln Glu Gln Arg Asp Ala Asp Ile Ala Glu Leu Val Arg Glu 505 510 515 caa cag cgc atg agc ggt ggg aca gaa aca aca gtt tta cgt gcc gag 1699 Gln Gln Arg Met Ser Gly Gly Thr Glu Thr Thr Val Leu Arg Ala Glu 520 525 530 cta gaa ggc ctg cac gtc cca gag gat cta gac cca tca att tct gtg 1747 Leu Glu Gly Leu His Val Pro Glu Asp Leu Asp Pro Ser Ile Ser Val 535 540 545 gat gat gcg caa act cag ttg aat gag gca gaa gag tcc aga gag ctc 1795 Asp Asp Ala Gln Thr Gln Leu Asn Glu Ala Glu Glu Ser Arg Glu Leu 550 555 560 565 gct gcg gag gcg cat aaa cac gca aat gca gca ctt gat gga ttg cgt 1843 Ala Ala Glu Ala His Lys His Ala Asn Ala Ala Leu Asp Gly Leu Arg 570 575 580 tcg cgt ccc gta gat aaa gct ctg aca gtt ttc aac gct cag ctc gca 1891 Ser Arg Pro Val Asp Lys Ala Leu Thr Val Phe Asn Ala Gln Leu Ala 585 590 595 gca ctg cag aga aac ctc tct tcc gca caa gtt gaa tta gac cgt gca 1939 Ala Leu Gln Arg Asn Leu Ser Ser Ala Gln Val Glu Leu Asp Arg Ala 600 605 610 gtg gca gaa acc tcg gat gac gaa gtt gat gct gct gta cag cgg tgc 1987 Val Ala Glu Thr Ser Asp Asp Glu Val Asp Ala Ala Val Gln Arg Cys 615 620 625 gct gaa gct cta gct ggg gtg cgg gta cag aag cag gag att gaa cag 2035 Ala Glu Ala Leu Ala Gly Val Arg Val Gln Lys Gln Glu Ile Glu Gln 630 635 640 645 gtc ttg gca aaa acc aac cca gac atg gct caa cgc tta tgt gat gct 2083 Val Leu Ala Lys Thr Asn Pro Asp Met Ala Gln Arg Leu Cys Asp Ala 650 655 660 gct gaa gca aat gtg cga tcg tat aaa acg gca gtg tct gat gcc acc 2131 Ala Glu Ala Asn Val Arg Ser Tyr Lys Thr Ala Val Ser Asp Ala Thr 665 670 675 aca gag ttg gtg cgc ctg gaa ggc ctc atc ggt gta gct gca ggt gcg 2179 Thr Glu Leu Val Arg Leu Glu Gly Leu Ile Gly Val Ala Ala Gly Ala 680 685 690 aaa gaa cga cta gat aaa gtt aag tct gcg ctg aca gca gct gaa aac 2227 Lys Glu Arg Leu Asp Lys Val Lys Ser Ala Leu Thr Ala Ala Glu Asn 695 700 705 cgg ttt gaa tca gaa caa cgt cgc gcc cac gct gca cgt cgc ctc tat 2275 Arg Phe Glu Ser Glu Gln Arg Arg Ala His Ala Ala Arg Arg Leu Tyr 710 715 720 725 gcc ctc atg gtg ttc tac cgt gat gaa tcc cga aag cgc tac gca gca 2323 Ala Leu Met Val Phe Tyr Arg Asp Glu Ser Arg Lys Arg Tyr Ala Ala 730 735 740 ccc ttc gcg gac aaa cta tcc agg ctg gca gca tcc gta ttt gga gaa 2371 Pro Phe Ala Asp Lys Leu Ser Arg Leu Ala Ala Ser Val Phe Gly Glu 745 750 755 tca gca gac ttt gat ctt gat gat gag ctg aag atc tcc agt cgt tcc 2419 Ser Ala Asp Phe Asp Leu Asp Asp Glu Leu Lys Ile Ser Ser Arg Ser 760 765 770 ata gga cca cga aca gtg gac ctt gcc aat ctt tct ggc ggc gca aag 2467 Ile Gly Pro Arg Thr Val Asp Leu Ala Asn Leu Ser Gly Gly Ala Lys 775 780 785 gaa cag ctg gca atc ctc acc cgc ttt gct atc gca gaa ttg gta gca 2515 Glu Gln Leu Ala Ile Leu Thr Arg Phe Ala Ile Ala Glu Leu Val Ala 790 795 800 805 gaa tcc tcc gcg caa ggt gct gtg cct gtg ttt att gat gat gca ttg 2563 Glu Ser Ser Ala Gln Gly Ala Val Pro Val Phe Ile Asp Asp Ala Leu 810 815 820 ggg agc aca gac cca gag cga ctg acc cgc ata tct act ctg ttt agt 2611 Gly Ser Thr Asp Pro Glu Arg Leu Thr Arg Ile Ser Thr Leu Phe Ser 825 830 835 gat gca ggc aag gac tct cag gtg ttt gtt ctc acc tgt gtt cca gac 2659 Asp Ala Gly Lys Asp Ser Gln Val Phe Val Leu Thr Cys Val Pro Asp 840 845 850 cgg tac aac tat gta gag gtc acc caa aag cac agc atc gag tca ttg 2707 Arg Tyr Asn Tyr Val Glu Val Thr Gln Lys His Ser Ile Glu Ser Leu 855 860 865 aaa act gcc aac gct ctg ctg tagctgagca aaaagccaag caagtagctg 2758 Lys Thr Ala Asn Ala Leu Leu 870 875 <210> 28 <211> 876 <212> PRT <213> Corynebacterium glutamicum <400> 28 Met Arg Ile His Glu Ile Ile Ile Asp Asn Phe Arg Ala Ile Glu His 1 5 10 15 Leu Glu Leu Arg Asp Ile Pro Asp Gln Gly Val Ile Val Ile His Gly 20 25 30 Asp Asn Glu Gln Gly Lys Ser Ser Ile Leu Glu Ala Ile Lys Thr Val 35 40 45 Leu Asn Ser Lys His Arg Thr Thr Ser Lys Thr Ile Lys Ala Ile Gln 50 55 60 Pro Val Asp Arg Asp Val Pro Ile Ser Ile Thr Leu Glu Ala Thr Val 65 70 75 80 Gly Thr Val Arg Phe Arg Ile His Lys Arg Phe Leu Lys Ser Thr Ala 85 90 95 Ala Glu Leu Gln Val Ile Glu Pro Arg Pro Ser Asn His Arg Gly Leu 100 105 110 Glu Ala Glu Ala Ala Leu Ala Glu Ile Leu Glu Ser His Leu Asp Thr 115 120 125 Ser Leu Leu Asp Ala Leu Phe Met Lys Gln Gly Glu Val Glu Ala Gly 130 135 140 Ile Ser Ala Val Gly Ile Pro Thr Leu Thr Ser Ala Leu Asn Ala Gln 145 150 155 160 Asn Gly Asn Thr Glu Asp Ala Thr Glu Asp Thr Ala Leu Met Glu Ala 165 170 175 Val Glu Lys Glu Tyr Leu Lys Phe Tyr Thr Asn Ser Gly Lys Ala Asn 180 185 190 Thr Arg Phe Leu Gln Phe Ser Lys Gln Val Glu Thr Leu Arg Thr Asp 195 200 205 Leu Asp Glu Ala Asn Ala Glu Val Ala Lys Leu Ser Ser His Val Asp 210 215 220 Arg Val Lys Arg Leu Glu Ile Asp Arg Asp Gln Ala Thr Ala Gln Leu 225 230 235 240 Pro Lys Ala Glu Glu Glu Leu Ala Gly Arg Lys Ala Glu Leu Glu Glu 245 250 255 Ala Gln Lys Val Lys Ala Gln Ala Thr Glu Ile Leu Ala Gln Phe Ser 260 265 270 Arg Ala Glu Glu Gln Leu Glu Gln Ala Thr Gly Ala Gln Lys Arg Arg 275 280 285 Lys Glu Leu Arg Asn Lys Leu Glu Leu Ala Gln Thr Glu Val Glu Lys 290 295 300 Ala Glu Ala Gly Gln Glu Asn Leu Ala Gln Glu Ala Ser Arg Glu Ala 305 310 315 320 Glu Glu Phe Leu Ala Leu Ser Glu Lys Phe Glu Ala Ala Arg Ala Ala 325 330 335 Glu Thr Leu Ala Val Glu Lys Val Lys Ala Ala Arg Gln Ser Val Ala 340 345 350 Gly Ile Lys Asn Arg Asp Arg Lys Glu His Leu Thr Val Met Leu Gly 355 360 365 Glu Leu Asp Arg Ile Gly Gln Arg Leu Tyr Glu Leu Arg Ser Val Gln 370 375 380 His Ser Ser Val Arg Val Ser Gln Arg Asp Ile Asp Ala Leu Gln Lys 385 390 395 400 Ala Ile Thr Glu Val Asp Ile Gln Arg Thr Leu Val Glu Ala Gln Gln 405 410 415 Gly Ser Ile Thr Leu Ser Ala Ser Thr Pro Thr Asp Ile Gln Leu Gly 420 425 430 Asp Asp Thr Val Ser Ala Thr Asp Ala Gly Thr Thr Val Ala Leu Asp 435 440 445 Arg Glu Leu Thr Val Val Val Gly Asp Val Thr Leu Val Ile Asn Pro 450 455 460 Gly Lys Thr Ala Ala Glu Ser Arg Thr Asp Phe Glu Ser Ala Glu Ala 465 470 475 480 Ala Leu Ala Glu Leu Leu Asp Gln Leu Asp Val Ser Asp Leu Asp Gln 485 490 495 Leu Arg Glu Arg Phe Thr Ala Gln Glu Gln Arg Asp Ala Asp Ile Ala 500 505 510 Glu Leu Val Arg Glu Gln Gln Arg Met Ser Gly Gly Thr Glu Thr Thr 515 520 525 Val Leu Arg Ala Glu Leu Glu Gly Leu His Val Pro Glu Asp Leu Asp 530 535 540 Pro Ser Ile Ser Val Asp Asp Ala Gln Thr Gln Leu Asn Glu Ala Glu 545 550 555 560 Glu Ser Arg Glu Leu Ala Ala Glu Ala His Lys His Ala Asn Ala Ala 565 570 575 Leu Asp Gly Leu Arg Ser Arg Pro Val Asp Lys Ala Leu Thr Val Phe 580 585 590 Asn Ala Gln Leu Ala Ala Leu Gln Arg Asn Leu Ser Ser Ala Gln Val 595 600 605 Glu Leu Asp Arg Ala Val Ala Glu Thr Ser Asp Asp Glu Val Asp Ala 610 615 620 Ala Val Gln Arg Cys Ala Glu Ala Leu Ala Gly Val Arg Val Gln Lys 625 630 635 640 Gln Glu Ile Glu Gln Val Leu Ala Lys Thr Asn Pro Asp Met Ala Gln 645 650 655 Arg Leu Cys Asp Ala Ala Glu Ala Asn Val Arg Ser Tyr Lys Thr Ala 660 665 670 Val Ser Asp Ala Thr Thr Glu Leu Val Arg Leu Glu Gly Leu Ile Gly 675 680 685 Val Ala Ala Gly Ala Lys Glu Arg Leu Asp Lys Val Lys Ser Ala Leu 690 695 700 Thr Ala Ala Glu Asn Arg Phe Glu Ser Glu Gln Arg Arg Ala His Ala 705 710 715 720 Ala Arg Arg Leu Tyr Ala Leu Met Val Phe Tyr Arg Asp Glu Ser Arg 725 730 735 Lys Arg Tyr Ala Ala Pro Phe Ala Asp Lys Leu Ser Arg Leu Ala Ala 740 745 750 Ser Val Phe Gly Glu Ser Ala Asp Phe Asp Leu Asp Asp Glu Leu Lys 755 760 765 Ile Ser Ser Arg Ser Ile Gly Pro Arg Thr Val Asp Leu Ala Asn Leu 770 775 780 Ser Gly Gly Ala Lys Glu Gln Leu Ala Ile Leu Thr Arg Phe Ala Ile 785 790 795 800 Ala Glu Leu Val Ala Glu Ser Ser Ala Gln Gly Ala Val Pro Val Phe 805 810 815 Ile Asp Asp Ala Leu Gly Ser Thr Asp Pro Glu Arg Leu Thr Arg Ile 820 825 830 Ser Thr Leu Phe Ser Asp Ala Gly Lys Asp Ser Gln Val Phe Val Leu 835 840 845 Thr Cys Val Pro Asp Arg Tyr Asn Tyr Val Glu Val Thr Gln Lys His 850 855 860 Ser Ile Glu Ser Leu Lys Thr Ala Asn Ala Leu Leu 865 870 875 <210> 29 <211> 1342 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1312) <223> RXA00197 <400> 29 gtcgatgata ttttggcaac cgaatctgag gcacgcgcgc gtgcgaatgc tttgatcaac 60 cggttggcaa ccaacttgta agctaaggag cttccgcctc gtg gca gcc tat ctt 115 Val Ala Ala Tyr Leu 1 5 ctt ggt gtc gta tta ttt ttc ctc ggc atc gca gta acc atc gcg ctt 163 Leu Gly Val Val Leu Phe Phe Leu Gly Ile Ala Val Thr Ile Ala Leu 10 15 20 cac gag tgg ggg cac ttc atc aca gcg cgc att ttc gga atg aaa gtg 211 His Glu Trp Gly His Phe Ile Thr Ala Arg Ile Phe Gly Met Lys Val 25 30 35 cgg cgt ttc ttc atc ggt ttc ggc ccg acg gtg ttt gcc aaa aga cgc 259 Arg Arg Phe Phe Ile Gly Phe Gly Pro Thr Val Phe Ala Lys Arg Arg 40 45 50 ggc gaa acc gtg tac ggc ctt aaa gcg att ccg gtc ggc ggt ttt tgt 307 Gly Glu Thr Val Tyr Gly Leu Lys Ala Ile Pro Val Gly Gly Phe Cys 55 60 65 gac atc gcg ggg atg act gcc caa gat gaa ctt gat ccg gaa gac ctg 355 Asp Ile Ala Gly Met Thr Ala Gln Asp Glu Leu Asp Pro Glu Asp Leu 70 75 80 85 ccg cgc gcc atg tat cta aag ccc tgg tgg cag cgc ata att gtg ctt 403 Pro Arg Ala Met Tyr Leu Lys Pro Trp Trp Gln Arg Ile Ile Val Leu 90 95 100 tcc ggc ggc gtg atc atg aat ctg atc gtc ggc ttt ttg gtg ctt tac 451 Ser Gly Gly Val Ile Met Asn Leu Ile Val Gly Phe Leu Val Leu Tyr 105 110 115 ggc gtg gcg gtg agc tcc gga atc ccg aat ccg gat gtg gat acc acc 499 Gly Val Ala Val Ser Ser Gly Ile Pro Asn Pro Asp Val Asp Thr Thr 120 125 130 gcg aca gtc gac acc gtt cag tgc gtg ccg gaa acc caa att tcc gca 547 Ala Thr Val Asp Thr Val Gln Cys Val Pro Glu Thr Gln Ile Ser Ala 135 140 145 act gaa ctg tcc tcc tgc gta ggt tca ggc cca gcg ggc gac gcc ggc 595 Thr Glu Leu Ser Ser Cys Val Gly Ser Gly Pro Ala Gly Asp Ala Gly 150 155 160 165 att gag cac ggc gat aag att ttg gcc gtc aac ggc caa gag atg gca 643 Ile Glu His Gly Asp Lys Ile Leu Ala Val Asn Gly Gln Glu Met Ala 170 175 180 agc ttc acc gcc atc cgc gat gcg atc ctc gag ctc cca ggc gaa acg 691 Ser Phe Thr Ala Ile Arg Asp Ala Ile Leu Glu Leu Pro Gly Glu Thr 185 190 195 gca acg ctg acg att gaa cgg gag gga acg ctt ttc gac gtc gac ctc 739 Ala Thr Leu Thr Ile Glu Arg Glu Gly Thr Leu Phe Asp Val Asp Leu 200 205 210 cag gtt gcc tct gtc acc cgt ctc gcc tct gac ggt tca gaa att acc 787 Gln Val Ala Ser Val Thr Arg Leu Ala Ser Asp Gly Ser Glu Ile Thr 215 220 225 gtc ggc gcg gtg ggc atg tcg agc ctt cca ccg acc gat gtg tac aaa 835 Val Gly Ala Val Gly Met Ser Ser Leu Pro Pro Thr Asp Val Tyr Lys 230 235 240 245 aaa tac ggc cca atc gag ggt gtg gga gca act gca cgt ttc acc ggc 883 Lys Tyr Gly Pro Ile Glu Gly Val Gly Ala Thr Ala Arg Phe Thr Gly 250 255 260 gac atg atc agc gcc acg tgg gat ggc ctc aaa gcc ttc ccg gcg aaa 931 Asp Met Ile Ser Ala Thr Trp Asp Gly Leu Lys Ala Phe Pro Ala Lys 265 270 275 atc cca ggg gtc gtc gca tcc atc ttc ggt gca gaa cga gat gta gaa 979 Ile Pro Gly Val Val Ala Ser Ile Phe Gly Ala Glu Arg Asp Val Glu 280 285 290 agc ccc atg agt gtg gtg ggc gcg tca cgc atc ggc ggc gaa ttt gtc 1027 Ser Pro Met Ser Val Val Gly Ala Ser Arg Ile Gly Gly Glu Phe Val 295 300 305 gaa cgt tcc atg tgg gac atg ttc atg atg atg ctg gcc agc ctg aac 1075 Glu Arg Ser Met Trp Asp Met Phe Met Met Met Leu Ala Ser Leu Asn 310 315 320 325 ttc ttc ctc gcg ctg ttt aac ctc gtg ccg ctg cca cca ctt gat ggc 1123 Phe Phe Leu Ala Leu Phe Asn Leu Val Pro Leu Pro Pro Leu Asp Gly 330 335 340 gga cac att gcc gtg gtg atc tat gaa aaa atc cgc gac ttc ttc cgc 1171 Gly His Ile Ala Val Val Ile Tyr Glu Lys Ile Arg Asp Phe Phe Arg 345 350 355 aaa ctg cgc gga aaa cca gcg ggc ggc cca gcg gat tac acc aaa cta 1219 Lys Leu Arg Gly Lys Pro Ala Gly Gly Pro Ala Asp Tyr Thr Lys Leu 360 365 370 atg ccc gtc acc gta gct gtc gca gcc ttg ctg atg aca gtg gga ggc 1267 Met Pro Val Thr Val Ala Val Ala Ala Leu Leu Met Thr Val Gly Gly 375 380 385 ctg gtc att gtc gcc gat gtg gtc aat ccc atc cga ctc ttt ggc 1312 Leu Val Ile Val Ala Asp Val Val Asn Pro Ile Arg Leu Phe Gly 390 395 400 taacgatacg gaattgaact gccggcaccg 1342 <210> 30 <211> 404 <212> PRT <213> Corynebacterium glutamicum <400> 30 Val Ala Ala Tyr Leu Leu Gly Val Val Leu Phe Phe Leu Gly Ile Ala 1 5 10 15 Val Thr Ile Ala Leu His Glu Trp Gly His Phe Ile Thr Ala Arg Ile 20 25 30 Phe Gly Met Lys Val Arg Arg Phe Phe Ile Gly Phe Gly Pro Thr Val 35 40 45 Phe Ala Lys Arg Arg Gly Glu Thr Val Tyr Gly Leu Lys Ala Ile Pro 50 55 60 Val Gly Gly Phe Cys Asp Ile Ala Gly Met Thr Ala Gln Asp Glu Leu 65 70 75 80 Asp Pro Glu Asp Leu Pro Arg Ala Met Tyr Leu Lys Pro Trp Trp Gln 85 90 95 Arg Ile Ile Val Leu Ser Gly Gly Val Ile Met Asn Leu Ile Val Gly 100 105 110 Phe Leu Val Leu Tyr Gly Val Ala Val Ser Ser Gly Ile Pro Asn Pro 115 120 125 Asp Val Asp Thr Thr Ala Thr Val Asp Thr Val Gln Cys Val Pro Glu 130 135 140 Thr Gln Ile Ser Ala Thr Glu Leu Ser Ser Cys Val Gly Ser Gly Pro 145 150 155 160 Ala Gly Asp Ala Gly Ile Glu His Gly Asp Lys Ile Leu Ala Val Asn 165 170 175 Gly Gln Glu Met Ala Ser Phe Thr Ala Ile Arg Asp Ala Ile Leu Glu 180 185 190 Leu Pro Gly Glu Thr Ala Thr Leu Thr Ile Glu Arg Glu Gly Thr Leu 195 200 205 Phe Asp Val Asp Leu Gln Val Ala Ser Val Thr Arg Leu Ala Ser Asp 210 215 220 Gly Ser Glu Ile Thr Val Gly Ala Val Gly Met Ser Ser Leu Pro Pro 225 230 235 240 Thr Asp Val Tyr Lys Lys Tyr Gly Pro Ile Glu Gly Val Gly Ala Thr 245 250 255 Ala Arg Phe Thr Gly Asp Met Ile Ser Ala Thr Trp Asp Gly Leu Lys 260 265 270 Ala Phe Pro Ala Lys Ile Pro Gly Val Val Ala Ser Ile Phe Gly Ala 275 280 285 Glu Arg Asp Val Glu Ser Pro Met Ser Val Val Gly Ala Ser Arg Ile 290 295 300 Gly Gly Glu Phe Val Glu Arg Ser Met Trp Asp Met Phe Met Met Met 305 310 315 320 Leu Ala Ser Leu Asn Phe Phe Leu Ala Leu Phe Asn Leu Val Pro Leu 325 330 335 Pro Pro Leu Asp Gly Gly His Ile Ala Val Val Ile Tyr Glu Lys Ile 340 345 350 Arg Asp Phe Phe Arg Lys Leu Arg Gly Lys Pro Ala Gly Gly Pro Ala 355 360 365 Asp Tyr Thr Lys Leu Met Pro Val Thr Val Ala Val Ala Ala Leu Leu 370 375 380 Met Thr Val Gly Gly Leu Val Ile Val Ala Asp Val Val Asn Pro Ile 385 390 395 400 Arg Leu Phe Gly <210> 31 <211> 1615 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1585) <223> RXA00199 <400> 31 agtcagatcg cgcactcaat tagtcgcccg ggtttatcgc gcggaaattt cctgattagt 60 atccttaccc agcaccattt tttgtggttt gctctaagtt atg ggc gaa tca gta 115 Met Gly Glu Ser Val 1 5 agt act gac agg tac act ccg cag cag cgc acg cgt tat cgc cag ctg 163 Ser Thr Asp Arg Tyr Thr Pro Gln Gln Arg Thr Arg Tyr Arg Gln Leu 10 15 20 ctc atg gaa gat ctt gag att ttt gat cgg cat ttg cag cat tcc gat 211 Leu Met Glu Asp Leu Glu Ile Phe Asp Arg His Leu Gln His Ser Asp 25 30 35 ttt gag gat cag ggt tcc atc ggc ctc gag ttg gaa ctc aac ctc gtg 259 Phe Glu Asp Gln Gly Ser Ile Gly Leu Glu Leu Glu Leu Asn Leu Val 40 45 50 gat aag cat atg caa cct gct ttg gca ggc cac gcg gtg ctt tcc cat 307 Asp Lys His Met Gln Pro Ala Leu Ala Gly His Ala Val Leu Ser His 55 60 65 tta gac gat gag tac cag tcg gag atc ggt aac ttt aat gtt gaa atg 355 Leu Asp Asp Glu Tyr Gln Ser Glu Ile Gly Asn Phe Asn Val Glu Met 70 75 80 85 aac cac ccg cca cta tcc gtt aaa ggc gat gct tta cga cgc ctc gag 403 Asn His Pro Pro Leu Ser Val Lys Gly Asp Ala Leu Arg Arg Leu Glu 90 95 100 caa ggc atc acc tcg cgt cta ggt cgc gtg cgc gcg gcc gcc aca tcg 451 Gln Gly Ile Thr Ser Arg Leu Gly Arg Val Arg Ala Ala Ala Thr Ser 105 110 115 gag aac gtg aac gtg gcg atg atc ggc acg ctg ccc acc atc acc cca 499 Glu Asn Val Asn Val Ala Met Ile Gly Thr Leu Pro Thr Ile Thr Pro 120 125 130 gaa ttc ctc gaa gat ccg gca tgg atg acc caa gaa aac cgc tac cgt 547 Glu Phe Leu Glu Asp Pro Ala Trp Met Thr Gln Glu Asn Arg Tyr Arg 135 140 145 gcg ctg agc aat gcg gtg atg gaa tcg cgt ggc gag tta gtg cac atc 595 Ala Leu Ser Asn Ala Val Met Glu Ser Arg Gly Glu Leu Val His Ile 150 155 160 165 aac atc gcc gac cgt gaa caa atc atc cac gat ttc act gat ctc gcc 643 Asn Ile Ala Asp Arg Glu Gln Ile Ile His Asp Phe Thr Asp Leu Ala 170 175 180 ccc gaa tca act tgc acg tct att cag ttg cac ctg caa tta gca ccc 691 Pro Glu Ser Thr Cys Thr Ser Ile Gln Leu His Leu Gln Leu Ala Pro 185 190 195 aat aag ttt gct gca gcg tgg aat gcg tcg caa gca ata gct ggt gtt 739 Asn Lys Phe Ala Ala Ala Trp Asn Ala Ser Gln Ala Ile Ala Gly Val 200 205 210 caa gca gct ctt tcc gcc aac tcc cca ctt ttc cta ggc cgt cgg gtg 787 Gln Ala Ala Leu Ser Ala Asn Ser Pro Leu Phe Leu Gly Arg Arg Val 215 220 225 tgg cat gaa agc cgc att cca gtg ttt caa caa gct atc gat acg cgt 835 Trp His Glu Ser Arg Ile Pro Val Phe Gln Gln Ala Ile Asp Thr Arg 230 235 240 245 act cct gaa ctt gtg aat caa gga gtc cgc ccc aga gta tgg ttc ggc 883 Thr Pro Glu Leu Val Asn Gln Gly Val Arg Pro Arg Val Trp Phe Gly 250 255 260 gaa cga tgg atc acc agt gtt ttt gat ctt ttc gaa gaa aac gta cgc 931 Glu Arg Trp Ile Thr Ser Val Phe Asp Leu Phe Glu Glu Asn Val Arg 265 270 275 tac ttc tcc cct ctc atc gca gaa tcc cgc gcc ctg tct ggc aca cca 979 Tyr Phe Ser Pro Leu Ile Ala Glu Ser Arg Ala Leu Ser Gly Thr Pro 280 285 290 atg atg aag gga aaa tcc ccc gca ctc cac tac ctc aat ctc cac aac 1027 Met Met Lys Gly Lys Ser Pro Ala Leu His Tyr Leu Asn Leu His Asn 295 300 305 gga acg gtg tgg cgc tgg aac cga ccc att tac gca ccg ggg gaa gag 1075 Gly Thr Val Trp Arg Trp Asn Arg Pro Ile Tyr Ala Pro Gly Glu Glu 310 315 320 325 cgc tct cat ctg cgt ttg gaa aac cgt ctc cta cct gca ggt ccc acc 1123 Arg Ser His Leu Arg Leu Glu Asn Arg Leu Leu Pro Ala Gly Pro Thr 330 335 340 ccc atc gac atc acc gcc gat gcc gct ttc tac tac ggt ttg gtt aaa 1171 Pro Ile Asp Ile Thr Ala Asp Ala Ala Phe Tyr Tyr Gly Leu Val Lys 345 350 355 tat ctg gcc gag gaa aac cgc cct gtc tgg tca cgt ctc cta ttc cct 1219 Tyr Leu Ala Glu Glu Asn Arg Pro Val Trp Ser Arg Leu Leu Phe Pro 360 365 370 gat gcg gaa aag aac ttc caa tcc ggt gca cgt tca ggg ctg ttc gcc 1267 Asp Ala Glu Lys Asn Phe Gln Ser Gly Ala Arg Ser Gly Leu Phe Ala 375 380 385 cgc atg acc tgg cca acc ctc gga caa gtc aac gtt gcg aat ctg gtc 1315 Arg Met Thr Trp Pro Thr Leu Gly Gln Val Asn Val Ala Asn Leu Val 390 395 400 405 caa gag cac ctc atc cct caa gcc aga atc gga ctg gaa cga ctc gaa 1363 Gln Glu His Leu Ile Pro Gln Ala Arg Ile Gly Leu Glu Arg Leu Glu 410 415 420 gta aac aaa gac ctt atc gac caa tac ctg ggc atc atc acc gaa cgc 1411 Val Asn Lys Asp Leu Ile Asp Gln Tyr Leu Gly Ile Ile Thr Glu Arg 425 430 435 gcg aag tcc cgc caa aac ggt gcc acc tgg cag ttg cgt agc ctc aac 1459 Ala Lys Ser Arg Gln Asn Gly Ala Thr Trp Gln Leu Arg Ser Leu Asn 440 445 450 aag ctg gaa gca cac gga agc atg ccg ggt tcc gat gct cga aaa gca 1507 Lys Leu Glu Ala His Gly Ser Met Pro Gly Ser Asp Ala Arg Lys Ala 455 460 465 ggt ctt gca gca atg ttg caa cag tat tta cag aat caa gaa agc ggc 1555 Gly Leu Ala Ala Met Leu Gln Gln Tyr Leu Gln Asn Gln Glu Ser Gly 470 475 480 485 caa cct gtc cac aca tgg gct att ggt tcg taaaacggca aggaaagata 1605 Gln Pro Val His Thr Trp Ala Ile Gly Ser 490 495 atacccggaa 1615 <210> 32 <211> 495 <212> PRT <213> Corynebacterium glutamicum <400> 32 Met Gly Glu Ser Val Ser Thr Asp Arg Tyr Thr Pro Gln Gln Arg Thr 1 5 10 15 Arg Tyr Arg Gln Leu Leu Met Glu Asp Leu Glu Ile Phe Asp Arg His 20 25 30 Leu Gln His Ser Asp Phe Glu Asp Gln Gly Ser Ile Gly Leu Glu Leu 35 40 45 Glu Leu Asn Leu Val Asp Lys His Met Gln Pro Ala Leu Ala Gly His 50 55 60 Ala Val Leu Ser His Leu Asp Asp Glu Tyr Gln Ser Glu Ile Gly Asn 65 70 75 80 Phe Asn Val Glu Met Asn His Pro Pro Leu Ser Val Lys Gly Asp Ala 85 90 95 Leu Arg Arg Leu Glu Gln Gly Ile Thr Ser Arg Leu Gly Arg Val Arg 100 105 110 Ala Ala Ala Thr Ser Glu Asn Val Asn Val Ala Met Ile Gly Thr Leu 115 120 125 Pro Thr Ile Thr Pro Glu Phe Leu Glu Asp Pro Ala Trp Met Thr Gln 130 135 140 Glu Asn Arg Tyr Arg Ala Leu Ser Asn Ala Val Met Glu Ser Arg Gly 145 150 155 160 Glu Leu Val His Ile Asn Ile Ala Asp Arg Glu Gln Ile Ile His Asp 165 170 175 Phe Thr Asp Leu Ala Pro Glu Ser Thr Cys Thr Ser Ile Gln Leu His 180 185 190 Leu Gln Leu Ala Pro Asn Lys Phe Ala Ala Ala Trp Asn Ala Ser Gln 195 200 205 Ala Ile Ala Gly Val Gln Ala Ala Leu Ser Ala Asn Ser Pro Leu Phe 210 215 220 Leu Gly Arg Arg Val Trp His Glu Ser Arg Ile Pro Val Phe Gln Gln 225 230 235 240 Ala Ile Asp Thr Arg Thr Pro Glu Leu Val Asn Gln Gly Val Arg Pro 245 250 255 Arg Val Trp Phe Gly Glu Arg Trp Ile Thr Ser Val Phe Asp Leu Phe 260 265 270 Glu Glu Asn Val Arg Tyr Phe Ser Pro Leu Ile Ala Glu Ser Arg Ala 275 280 285 Leu Ser Gly Thr Pro Met Met Lys Gly Lys Ser Pro Ala Leu His Tyr 290 295 300 Leu Asn Leu His Asn Gly Thr Val Trp Arg Trp Asn Arg Pro Ile Tyr 305 310 315 320 Ala Pro Gly Glu Glu Arg Ser His Leu Arg Leu Glu Asn Arg Leu Leu 325 330 335 Pro Ala Gly Pro Thr Pro Ile Asp Ile Thr Ala Asp Ala Ala Phe Tyr 340 345 350 Tyr Gly Leu Val Lys Tyr Leu Ala Glu Glu Asn Arg Pro Val Trp Ser 355 360 365 Arg Leu Leu Phe Pro Asp Ala Glu Lys Asn Phe Gln Ser Gly Ala Arg 370 375 380 Ser Gly Leu Phe Ala Arg Met Thr Trp Pro Thr Leu Gly Gln Val Asn 385 390 395 400 Val Ala Asn Leu Val Gln Glu His Leu Ile Pro Gln Ala Arg Ile Gly 405 410 415 Leu Glu Arg Leu Glu Val Asn Lys Asp Leu Ile Asp Gln Tyr Leu Gly 420 425 430 Ile Ile Thr Glu Arg Ala Lys Ser Arg Gln Asn Gly Ala Thr Trp Gln 435 440 445 Leu Arg Ser Leu Asn Lys Leu Glu Ala His Gly Ser Met Pro Gly Ser 450 455 460 Asp Ala Arg Lys Ala Gly Leu Ala Ala Met Leu Gln Gln Tyr Leu Gln 465 470 475 480 Asn Gln Glu Ser Gly Gln Pro Val His Thr Trp Ala Ile Gly Ser 485 490 495 <210> 33 <211> 793 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(763) <223> RXA00211 <400> 33 tgagccaaaa tcaataaggt gtttttcagc ctgaggtaaa aatacggtgg tactgtcgaa 60 accaatcatc ccctagtttt gaaaagaagg aagcgagcca atg tca ttc ctg atc 115 Met Ser Phe Leu Ile 1 5 cgc gtc ctg ttg tcc gac acc cca ggc agc ctc gcg tta ctc gct gaa 163 Arg Val Leu Leu Ser Asp Thr Pro Gly Ser Leu Ala Leu Leu Ala Glu 10 15 20 gcc ctt ggg att gta gag gcc aat att caa tcc gtg gac gtg gtg gaa 211 Ala Leu Gly Ile Val Glu Ala Asn Ile Gln Ser Val Asp Val Val Glu 25 30 35 cgc ttc ccc aat ggc acg gtc atg gac gat ctg gtg atc tcc atc cct 259 Arg Phe Pro Asn Gly Thr Val Met Asp Asp Leu Val Ile Ser Ile Pro 40 45 50 cgc gat gtc atg gca gac acc atc atc acc gca gct gaa gaa gtc gac 307 Arg Asp Val Met Ala Asp Thr Ile Ile Thr Ala Ala Glu Glu Val Asp 55 60 65 ggc gtg gag att gat tcc atc cgc cca ttc tcc ggg act gtt gac cgc 355 Gly Val Glu Ile Asp Ser Ile Arg Pro Phe Ser Gly Thr Val Asp Arg 70 75 80 85 cgc gga cag atc caa atg ctg gct gct gtt gct cac caa cgc cgc gat 403 Arg Gly Gln Ile Gln Met Leu Ala Ala Val Ala His Gln Arg Arg Asp 90 95 100 atc acc gca gcg atg gaa gaa atg gtc gat gtc atc ccc cgc acc atg 451 Ile Thr Ala Ala Met Glu Glu Met Val Asp Val Ile Pro Arg Thr Met 105 110 115 acc tct ggt tgg gct ttg gtc att gat cta aaa gga ccc atc act cgc 499 Thr Ser Gly Trp Ala Leu Val Ile Asp Leu Lys Gly Pro Ile Thr Arg 120 125 130 atc gct ggt tcc cta gca gcg ccc gaa gat gac ggc acc gtt ccg gag 547 Ile Ala Gly Ser Leu Ala Ala Pro Glu Asp Asp Gly Thr Val Pro Glu 135 140 145 aac atc gtt ctc aaa gaa gct cgc atg ctc aac ccg gaa aac gat ccg 595 Asn Ile Val Leu Lys Glu Ala Arg Met Leu Asn Pro Glu Asn Asp Pro 150 155 160 165 tgg att cca gag tcc tgg aca ctg ctt gat tct tcc ctt gcc atc gct 643 Trp Ile Pro Glu Ser Trp Thr Leu Leu Asp Ser Ser Leu Ala Ile Ala 170 175 180 ccg atc ggc aag cac ggc ctg gct ctg att atc ggt cgc cct ggt ggc 691 Pro Ile Gly Lys His Gly Leu Ala Leu Ile Ile Gly Arg Pro Gly Gly 185 190 195 cct gat ttc ttg gcc agc gaa gtg gag cac tta ggc caa gtc ggt gac 739 Pro Asp Phe Leu Ala Ser Glu Val Glu His Leu Gly Gln Val Gly Asp 200 205 210 att atc gga gca atg ctt caa aaa taatctgagc tgtttaaaaa atgccccaag 793 Ile Ile Gly Ala Met Leu Gln Lys 215 220 <210> 34 <211> 221 <212> PRT <213> Corynebacterium glutamicum <400> 34 Met Ser Phe Leu Ile Arg Val Leu Leu Ser Asp Thr Pro Gly Ser Leu 1 5 10 15 Ala Leu Leu Ala Glu Ala Leu Gly Ile Val Glu Ala Asn Ile Gln Ser 20 25 30 Val Asp Val Val Glu Arg Phe Pro Asn Gly Thr Val Met Asp Asp Leu 35 40 45 Val Ile Ser Ile Pro Arg Asp Val Met Ala Asp Thr Ile Ile Thr Ala 50 55 60 Ala Glu Glu Val Asp Gly Val Glu Ile Asp Ser Ile Arg Pro Phe Ser 65 70 75 80 Gly Thr Val Asp Arg Arg Gly Gln Ile Gln Met Leu Ala Ala Val Ala 85 90 95 His Gln Arg Arg Asp Ile Thr Ala Ala Met Glu Glu Met Val Asp Val 100 105 110 Ile Pro Arg Thr Met Thr Ser Gly Trp Ala Leu Val Ile Asp Leu Lys 115 120 125 Gly Pro Ile Thr Arg Ile Ala Gly Ser Leu Ala Ala Pro Glu Asp Asp 130 135 140 Gly Thr Val Pro Glu Asn Ile Val Leu Lys Glu Ala Arg Met Leu Asn 145 150 155 160 Pro Glu Asn Asp Pro Trp Ile Pro Glu Ser Trp Thr Leu Leu Asp Ser 165 170 175 Ser Leu Ala Ile Ala Pro Ile Gly Lys His Gly Leu Ala Leu Ile Ile 180 185 190 Gly Arg Pro Gly Gly Pro Asp Phe Leu Ala Ser Glu Val Glu His Leu 195 200 205 Gly Gln Val Gly Asp Ile Ile Gly Ala Met Leu Gln Lys 210 215 220 <210> 35 <211> 634 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(604) <223> RXA00220 <400> 35 agatcgtgcc gagtttccgg tttggatggg gtttgggatg ttaatgggag aggatcggcg 60 tgatcgtgcc ggtttttctt gcgttggtag tcttggggct atg agc gca ttc cac 115 Met Ser Ala Phe His 1 5 atc cga gcg gaa caa tcg cgc gat atc agc gcg att cat gat gtt act 163 Ile Arg Ala Glu Gln Ser Arg Asp Ile Ser Ala Ile His Asp Val Thr 10 15 20 gaa gcg gcc ttt aca gga att gag cat tca gat gga aca gag caa gat 211 Glu Ala Ala Phe Thr Gly Ile Glu His Ser Asp Gly Thr Glu Gln Asp 25 30 35 ctc gtc gat aag ctt cgt gct gca aag gcg ctg agc ctt tcg ctc gtc 259 Leu Val Asp Lys Leu Arg Ala Ala Lys Ala Leu Ser Leu Ser Leu Val 40 45 50 gct gag gcg gat ggc gag gtc att ggg cat atc gca gcc tct gag gta 307 Ala Glu Ala Asp Gly Glu Val Ile Gly His Ile Ala Ala Ser Glu Val 55 60 65 ctg atc ggc ggt ggg gtg cag ggc tgg ttt ggc att ggg cct gtc agt 355 Leu Ile Gly Gly Gly Val Gln Gly Trp Phe Gly Ile Gly Pro Val Ser 70 75 80 85 gtt cgg ccc gat aag cag cag caa ggc gtg ggt att gcg ctg atg ggc 403 Val Arg Pro Asp Lys Gln Gln Gln Gly Val Gly Ile Ala Leu Met Gly 90 95 100 agc gcg ctt gat cag ttg cgt gcg gag ggt gct ggc ggc atc gtg ttg 451 Ser Ala Leu Asp Gln Leu Arg Ala Glu Gly Ala Gly Gly Ile Val Leu 105 110 115 ctg ggg gat ccg ggc tat tat cga cgc ttc ggt ttt gag gtc gtg ccc 499 Leu Gly Asp Pro Gly Tyr Tyr Arg Arg Phe Gly Phe Glu Val Val Pro 120 125 130 ggg ctg gtc tat ccg gac gcg cca gcg gaa ttt ttt atg gct gtg tgt 547 Gly Leu Val Tyr Pro Asp Ala Pro Ala Glu Phe Phe Met Ala Val Cys 135 140 145 ttg aat gct ccg gcg ttt ccg cag ggt gtt gtg gag tat cac tcg gca 595 Leu Asn Ala Pro Ala Phe Pro Gln Gly Val Val Glu Tyr His Ser Ala 150 155 160 165 ttt gga ggg tagagacccc atcgtggcgg gcctgggctc 634 Phe Gly Gly <210> 36 <211> 168 <212> PRT <213> Corynebacterium glutamicum <400> 36 Met Ser Ala Phe His Ile Arg Ala Glu Gln Ser Arg Asp Ile Ser Ala 1 5 10 15 Ile His Asp Val Thr Glu Ala Ala Phe Thr Gly Ile Glu His Ser Asp 20 25 30 Gly Thr Glu Gln Asp Leu Val Asp Lys Leu Arg Ala Ala Lys Ala Leu 35 40 45 Ser Leu Ser Leu Val Ala Glu Ala Asp Gly Glu Val Ile Gly His Ile 50 55 60 Ala Ala Ser Glu Val Leu Ile Gly Gly Gly Val Gln Gly Trp Phe Gly 65 70 75 80 Ile Gly Pro Val Ser Val Arg Pro Asp Lys Gln Gln Gln Gly Val Gly 85 90 95 Ile Ala Leu Met Gly Ser Ala Leu Asp Gln Leu Arg Ala Glu Gly Ala 100 105 110 Gly Gly Ile Val Leu Leu Gly Asp Pro Gly Tyr Tyr Arg Arg Phe Gly 115 120 125 Phe Glu Val Val Pro Gly Leu Val Tyr Pro Asp Ala Pro Ala Glu Phe 130 135 140 Phe Met Ala Val Cys Leu Asn Ala Pro Ala Phe Pro Gln Gly Val Val 145 150 155 160 Glu Tyr His Ser Ala Phe Gly Gly 165 <210> 37 <211> 373 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(343) <223> RXA00240 <400> 37 ttgagacccc gcagaatctg attgagtatt cactcattta acgtagttga cgtacggcga 60 agtcgctaaa cttcgcgtaa tcttggggcc aattaatcaa gtg cag atg aat tgt 115 Val Gln Met Asn Cys 1 5 tta gaa agg ctg gag acc atg ggt att ttt gac gaa gct aag aag aag 163 Leu Glu Arg Leu Glu Thr Met Gly Ile Phe Asp Glu Ala Lys Lys Lys 10 15 20 gca acc gaa ttc ctc gac tct gat tca ggc gag cag aag tcc gat gga 211 Ala Thr Glu Phe Leu Asp Ser Asp Ser Gly Glu Gln Lys Ser Asp Gly 25 30 35 ctg ctg gat aag gcc gca gac aaa gct aag ggt ctc ctc ggt gaa gac 259 Leu Leu Asp Lys Ala Ala Asp Lys Ala Lys Gly Leu Leu Gly Glu Asp 40 45 50 aaa gcg gat cag att aac aag gtc cgt gac gct gtc gat gag cgc att 307 Lys Ala Asp Gln Ile Asn Lys Val Arg Asp Ala Val Asp Glu Arg Ile 55 60 65 ggc aaa aac aac ggc ggc gaa gag aat cca gcc aac tagtattagg 353 Gly Lys Asn Asn Gly Gly Glu Glu Asn Pro Ala Asn 70 75 80 cgtcatgcgc gtcgtagttg 373 <210> 38 <211> 81 <212> PRT <213> Corynebacterium glutamicum <400> 38 Val Gln Met Asn Cys Leu Glu Arg Leu Glu Thr Met Gly Ile Phe Asp 1 5 10 15 Glu Ala Lys Lys Lys Ala Thr Glu Phe Leu Asp Ser Asp Ser Gly Glu 20 25 30 Gln Lys Ser Asp Gly Leu Leu Asp Lys Ala Ala Asp Lys Ala Lys Gly 35 40 45 Leu Leu Gly Glu Asp Lys Ala Asp Gln Ile Asn Lys Val Arg Asp Ala 50 55 60 Val Asp Glu Arg Ile Gly Lys Asn Asn Gly Gly Glu Glu Asn Pro Ala 65 70 75 80 Asn <210> 39 <211> 943 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(913) <223> RXA00354 <400> 39 ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60 ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115 Met Gly Lys Leu Leu 1 5 ttc gta gac atc ggt ggc aca ctg ctg gat tac tca aat gaa gtt ccg 163 Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro 10 15 20 cgt tcg gcc gtt gac gcg atc cgt aag gca cgc gcc aaa gga cac cgc 211 Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg 25 30 35 gtg tac ttg agc tct ggt cga agc agc gct gag gtg act tct cag ttg 259 Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu Val Thr Ser Gln Leu 40 45 50 tgg gat atc gga gtg gat ggc ctc att ggc gca aat ggt gga tat gtg 307 Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala Asn Gly Gly Tyr Val 55 60 65 gaa agc gca cag gag tct gtg ttc cac cgc cgt ttg tcg ggt gag gag 355 Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu 70 75 80 85 acc cgc cac att gtg gag tgg ctc tac aac cgt ggt ttg gag ttt tat 403 Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr 90 95 100 ctc gag tcc aac aac ggt ttg tat gca agc cgt ggt ttc cgt gag gct 451 Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala 105 110 115 tct aag cca gtg ctg tct cgc ctt tcg gag aag acc gac gtg aca gtc 499 Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val 120 125 130 gat agc atg tac ccg gat atg ttc tgg ggc gcg agc ctt gat cgt gac 547 Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp 135 140 145 gat gtg aac aag atc agt tac atc ttc aat tct cag gaa gat ttg gac 595 Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser Gln Glu Asp Leu Asp 150 155 160 165 gca gcg cgt gag gcg ttc cct aac ctg gag cac acc acg tgg ggt ggt 643 Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly 170 175 180 cag acg ggt gcg ttg ttc ggc acg atc ggt gtg tct gtc aac aag aag 691 Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val Ser Val Asn Lys Lys 185 190 195 atc ggc gtg gat cgc ctg ctg aag tac ctg aac gca gat cgc gca aac 739 Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Ala Asp Arg Ala Asn 200 205 210 acc att gcg ttc ggc gac agc gat gag gat ctc tcc cta ttt gag gcg 787 Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Ala 215 220 225 agc gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg ctc aag gct 835 Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr Glu Ser Leu Lys Ala 230 235 240 245 gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883 Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln Asp Gly Leu Arg Asn 250 255 260 gcg ttt tta aag ctt gag ctt atc gac gcc tgaccccatc aaagaacttc 933 Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala 265 270 ccaatctcct 943 <210> 40 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 40 Met Gly Lys Leu Leu Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr 1 5 10 15 Ser Asn Glu Val Pro Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg 20 25 30 Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu 35 40 45 Val Thr Ser Gln Leu Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala 50 55 60 Asn Gly Gly Tyr Val Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg 65 70 75 80 Leu Ser Gly Glu Glu Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg 85 90 95 Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg 100 105 110 Gly Phe Arg Glu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys 115 120 125 Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala 130 135 140 Ser Leu Asp Arg Asp Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser 145 150 155 160 Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His 165 170 175 Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val 180 185 190 Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn 195 200 205 Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu 210 215 220 Ser Leu Phe Glu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr 225 230 235 240 Glu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln 245 250 255 Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala 260 265 270 <210> 41 <211> 931 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(901) <223> RXA00397 <400> 41 tttttcgagg ttggggtggc ttttcgggtg gcgtgtatgt attaaaccaa ggagcttgtt 60 tgagggggag cgcttggttt gattcgacag ttttcgggca ttg agc ctg acg gaa 115 Leu Ser Leu Thr Glu 1 5 ggg gag atc att ccc atc caa aca aag ctc ggc cac tgg cgt gac gtg 163 Gly Glu Ile Ile Pro Ile Gln Thr Lys Leu Gly His Trp Arg Asp Val 10 15 20 cgg gat tcc gaa gat ctg cca ttc caa gta atc gca tcg cgc acc agc 211 Arg Asp Ser Glu Asp Leu Pro Phe Gln Val Ile Ala Ser Arg Thr Ser 25 30 35 gtg acc att atg gaa aac acc ctg gaa tgg acc aac agc cgc ctt gag 259 Val Thr Ile Met Glu Asn Thr Leu Glu Trp Thr Asn Ser Arg Leu Glu 40 45 50 cgt ggc gaa gag ttc acc gag ctc gac att tat gct cac tac ttg gaa 307 Arg Gly Glu Glu Phe Thr Glu Leu Asp Ile Tyr Ala His Tyr Leu Glu 55 60 65 gag ttg gaa gat tac gcc ctc caa ttc acc ttc gat gtc gag ccc tac 355 Glu Leu Glu Asp Tyr Ala Leu Gln Phe Thr Phe Asp Val Glu Pro Tyr 70 75 80 85 ttc acc aac ctg cac tcc tcc aac aga atg ctc ttc cct gga cct cct 403 Phe Thr Asn Leu His Ser Ser Asn Arg Met Leu Phe Pro Gly Pro Pro 90 95 100 gtg gat ttc ccg atc aac gca gaa acc cga tgc att cag ctc gac gcc 451 Val Asp Phe Pro Ile Asn Ala Glu Thr Arg Cys Ile Gln Leu Asp Ala 105 110 115 ggt gtt gca gta aag aag gac ggc gtg gtg ctg ggt acc tca gat atg 499 Gly Val Ala Val Lys Lys Asp Gly Val Val Leu Gly Thr Ser Asp Met 120 125 130 gcg agg tcc ctg cct cga acc gcc gct ggc caa gaa gcc tat gag tac 547 Ala Arg Ser Leu Pro Arg Thr Ala Ala Gly Gln Glu Ala Tyr Glu Tyr 135 140 145 ttc ttc aag gtg gtt cgt gaa ggc atc atc ggg cag ctg cgc ccg ggc 595 Phe Phe Lys Val Val Arg Glu Gly Ile Ile Gly Gln Leu Arg Pro Gly 150 155 160 165 gtg atc tgc gct gac gtg cac gaa gca acc ctt gat tac cta agc ccg 643 Val Ile Cys Ala Asp Val His Glu Ala Thr Leu Asp Tyr Leu Ser Pro 170 175 180 cag cta cct cgc atg att gac atc gga atg ctg ggt gcc gac acc gat 691 Gln Leu Pro Arg Met Ile Asp Ile Gly Met Leu Gly Ala Asp Thr Asp 185 190 195 ttc aac acc atc tac cgc aag cgc aat gtt ggc cac ctc atg ggc aag 739 Phe Asn Thr Ile Tyr Arg Lys Arg Asn Val Gly His Leu Met Gly Lys 200 205 210 cag gaa tcc ttt gcc aat gag ctt cgc cct gga tac aag cac att ctt 787 Gln Glu Ser Phe Ala Asn Glu Leu Arg Pro Gly Tyr Lys His Ile Leu 215 220 225 cac cac ggc tcc tat ggt gcc gcg gag atc cct tgg cgc tac aac ggt 835 His His Gly Ser Tyr Gly Ala Ala Glu Ile Pro Trp Arg Tyr Asn Gly 230 235 240 245 gta gcc att ggt acc gag gat ctg tgg tac atc ggc gca gac aag acc 883 Val Ala Ile Gly Thr Glu Asp Leu Trp Tyr Ile Gly Ala Asp Lys Thr 250 255 260 tac att ttg agc cag cgc taaggagaac ccagtgacag aaattgcaga 931 Tyr Ile Leu Ser Gln Arg 265 <210> 42 <211> 267 <212> PRT <213> Corynebacterium glutamicum <400> 42 Leu Ser Leu Thr Glu Gly Glu Ile Ile Pro Ile Gln Thr Lys Leu Gly 1 5 10 15 His Trp Arg Asp Val Arg Asp Ser Glu Asp Leu Pro Phe Gln Val Ile 20 25 30 Ala Ser Arg Thr Ser Val Thr Ile Met Glu Asn Thr Leu Glu Trp Thr 35 40 45 Asn Ser Arg Leu Glu Arg Gly Glu Glu Phe Thr Glu Leu Asp Ile Tyr 50 55 60 Ala His Tyr Leu Glu Glu Leu Glu Asp Tyr Ala Leu Gln Phe Thr Phe 65 70 75 80 Asp Val Glu Pro Tyr Phe Thr Asn Leu His Ser Ser Asn Arg Met Leu 85 90 95 Phe Pro Gly Pro Pro Val Asp Phe Pro Ile Asn Ala Glu Thr Arg Cys 100 105 110 Ile Gln Leu Asp Ala Gly Val Ala Val Lys Lys Asp Gly Val Val Leu 115 120 125 Gly Thr Ser Asp Met Ala Arg Ser Leu Pro Arg Thr Ala Ala Gly Gln 130 135 140 Glu Ala Tyr Glu Tyr Phe Phe Lys Val Val Arg Glu Gly Ile Ile Gly 145 150 155 160 Gln Leu Arg Pro Gly Val Ile Cys Ala Asp Val His Glu Ala Thr Leu 165 170 175 Asp Tyr Leu Ser Pro Gln Leu Pro Arg Met Ile Asp Ile Gly Met Leu 180 185 190 Gly Ala Asp Thr Asp Phe Asn Thr Ile Tyr Arg Lys Arg Asn Val Gly 195 200 205 His Leu Met Gly Lys Gln Glu Ser Phe Ala Asn Glu Leu Arg Pro Gly 210 215 220 Tyr Lys His Ile Leu His His Gly Ser Tyr Gly Ala Ala Glu Ile Pro 225 230 235 240 Trp Arg Tyr Asn Gly Val Ala Ile Gly Thr Glu Asp Leu Trp Tyr Ile 245 250 255 Gly Ala Asp Lys Thr Tyr Ile Leu Ser Gln Arg 260 265 <210> 43 <211> 1543 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1513) <223> RXA00409 <400> 43 cggcgtcctc tgactccacc attcaaggcc tgcctgtcgc ggaagccgat gccttacgtg 60 agcgactggc tattaaggcc cgggagagga tgagcggact atg agc agc ctt gaa 115 Met Ser Ser Leu Glu 1 5 ggg ttt cga aaa gtc cac cgc gcc acc cca ttc ctt cgc atc tgg acc 163 Gly Phe Arg Lys Val His Arg Ala Thr Pro Phe Leu Arg Ile Trp Thr 10 15 20 atc atc gtc gca gtt ctc gcg gca ttc gca ttc aat tcc ggc gca tcc 211 Ile Ile Val Ala Val Leu Ala Ala Phe Ala Phe Asn Ser Gly Ala Ser 25 30 35 gtt tta agt ttc atc tgg ggt gtc gtc acc ggc gaa tac gga ttc gca 259 Val Leu Ser Phe Ile Trp Gly Val Val Thr Gly Glu Tyr Gly Phe Ala 40 45 50 gtg ctg ccg att cta ttg acc gtc ggt ggc gcc gtc att gtg gtg gca 307 Val Leu Pro Ile Leu Leu Thr Val Gly Gly Ala Val Ile Val Val Ala 55 60 65 ctg gcc tgg att atc acc gga att tgg tgg aaa gcc gtc gga ttc cgc 355 Leu Ala Trp Ile Ile Thr Gly Ile Trp Trp Lys Ala Val Gly Phe Arg 70 75 80 85 atc acc aat gaa gag gtg cag ctg caa cgc gga gtg atc agc aaa gac 403 Ile Thr Asn Glu Glu Val Gln Leu Gln Arg Gly Val Ile Ser Lys Asp 90 95 100 ctc cgc acc gcc cga ttt gac cgt atc caa gcc gtt gac ctg gtg gaa 451 Leu Arg Thr Ala Arg Phe Asp Arg Ile Gln Ala Val Asp Leu Val Glu 105 110 115 tca ttc atc gcc cgt atc ttc cga ctg gca gaa gtc cgc atc gaa acc 499 Ser Phe Ile Ala Arg Ile Phe Arg Leu Ala Glu Val Arg Ile Glu Thr 120 125 130 gcc ggc ggc agc gac tcc gcc atc agc att ggc ttt tta aga aaa agc 547 Ala Gly Gly Ser Asp Ser Ala Ile Ser Ile Gly Phe Leu Arg Lys Ser 135 140 145 gag gcc gag gcc cta aaa agg gag ctt ctc gac gcc tcc cag cac tca 595 Glu Ala Glu Ala Leu Lys Arg Glu Leu Leu Asp Ala Ser Gln His Ser 150 155 160 165 gtc gcc acc acc cca gcc gga gtt ccg gct gag cct ggg gta ggg gag 643 Val Ala Thr Thr Pro Ala Gly Val Pro Ala Glu Pro Gly Val Gly Glu 170 175 180 acc gtt gta gtt gag agc gcg ggc gat gtt ctg gtt cca caa atc ccc 691 Thr Val Val Val Glu Ser Ala Gly Asp Val Leu Val Pro Gln Ile Pro 185 190 195 gtg caa cgc acc ctc gcc agc acc gcc tta tca cta gca acc atc atc 739 Val Gln Arg Thr Leu Ala Ser Thr Ala Leu Ser Leu Ala Thr Ile Ile 200 205 210 acc gcg atc ggt att gtg att ttg ctc ttc gtt cct ttc gga gtg agc 787 Thr Ala Ile Gly Ile Val Ile Leu Leu Phe Val Pro Phe Gly Val Ser 215 220 225 att gcc gtg ccg ttc ttt gta ggc atg gtg cca gcg gtc tgg aac ttg 835 Ile Ala Val Pro Phe Phe Val Gly Met Val Pro Ala Val Trp Asn Leu 230 235 240 245 atc gat aag tcg tgg caa ttc acc gca aca cag cgc aac gat gtc ctg 883 Ile Asp Lys Ser Trp Gln Phe Thr Ala Thr Gln Arg Asn Asp Val Leu 250 255 260 cat gtc agc tat gga ctt gcc aac cgc cgc aaa caa tca atc cca ctg 931 His Val Ser Tyr Gly Leu Ala Asn Arg Arg Lys Gln Ser Ile Pro Leu 265 270 275 gga cgc atc cac gca gtg aaa cta aaa cag cca ttg ctg tgg cga ctg 979 Gly Arg Ile His Ala Val Lys Leu Lys Gln Pro Leu Leu Trp Arg Leu 280 285 290 gtt ggc tgg tgg acc gtg acc gtg act gta gtt ggc tac ggc gac acc 1027 Val Gly Trp Trp Thr Val Thr Val Thr Val Val Gly Tyr Gly Asp Thr 295 300 305 acc caa ggc gga acc tcc aaa atc ttg ccc gtg ggt tcc aaa gaa ctc 1075 Thr Gln Gly Gly Thr Ser Lys Ile Leu Pro Val Gly Ser Lys Glu Leu 310 315 320 325 gca cta aaa gtc ctt gaa gcg gtg ggg cca cta aac agc gcc gac atc 1123 Ala Leu Lys Val Leu Glu Ala Val Gly Pro Leu Asn Ser Ala Asp Ile 330 335 340 gcc gaa tct gca gac cca tca cat atg agc aga ccc cag tac aca cca 1171 Ala Glu Ser Ala Asp Pro Ser His Met Ser Arg Pro Gln Tyr Thr Pro 345 350 355 cca gtt gct gca cgc ctg ctc aca cca gtc gat cgg acc cgc caa ggc 1219 Pro Val Ala Ala Arg Leu Leu Thr Pro Val Asp Arg Thr Arg Gln Gly 360 365 370 gtc acg ttg att ggt gtg gct ggt gcc cct ggt gcg gtg gtc gtg cat 1267 Val Thr Leu Ile Gly Val Ala Gly Ala Pro Gly Ala Val Val Val His 375 380 385 gaa ggc aga ttc atg cca cgt atg tct gtg att gat acc tcc cac atc 1315 Glu Gly Arg Phe Met Pro Arg Met Ser Val Ile Asp Thr Ser His Ile 390 395 400 405 caa gaa ctc acc ctt aaa cac ggg ccg atc caa aga ata ctg gga ctc 1363 Gln Glu Leu Thr Leu Lys His Gly Pro Ile Gln Arg Ile Leu Gly Leu 410 415 420 tcc acc gtt gtg ttt aac ctg gtc caa ggg cca gtg gga atg gcc gca 1411 Ser Thr Val Val Phe Asn Leu Val Gln Gly Pro Val Gly Met Ala Ala 425 430 435 tcg gat ctc agt gca gct gat gga aaa gaa ctt ctc aac att ctc cgc 1459 Ser Asp Leu Ser Ala Ala Asp Gly Lys Glu Leu Leu Asn Ile Leu Arg 440 445 450 aac aga aaa cta ccc gca ctg gaa tca gct ccg ctg gga caa aac agc 1507 Asn Arg Lys Leu Pro Ala Leu Glu Ser Ala Pro Leu Gly Gln Asn Ser 455 460 465 ctg gac taaggtgtaa tcatgcacat ctcagatctt 1543 Leu Asp 470 <210> 44 <211> 471 <212> PRT <213> Corynebacterium glutamicum <400> 44 Met Ser Ser Leu Glu Gly Phe Arg Lys Val His Arg Ala Thr Pro Phe 1 5 10 15 Leu Arg Ile Trp Thr Ile Ile Val Ala Val Leu Ala Ala Phe Ala Phe 20 25 30 Asn Ser Gly Ala Ser Val Leu Ser Phe Ile Trp Gly Val Val Thr Gly 35 40 45 Glu Tyr Gly Phe Ala Val Leu Pro Ile Leu Leu Thr Val Gly Gly Ala 50 55 60 Val Ile Val Val Ala Leu Ala Trp Ile Ile Thr Gly Ile Trp Trp Lys 65 70 75 80 Ala Val Gly Phe Arg Ile Thr Asn Glu Glu Val Gln Leu Gln Arg Gly 85 90 95 Val Ile Ser Lys Asp Leu Arg Thr Ala Arg Phe Asp Arg Ile Gln Ala 100 105 110 Val Asp Leu Val Glu Ser Phe Ile Ala Arg Ile Phe Arg Leu Ala Glu 115 120 125 Val Arg Ile Glu Thr Ala Gly Gly Ser Asp Ser Ala Ile Ser Ile Gly 130 135 140 Phe Leu Arg Lys Ser Glu Ala Glu Ala Leu Lys Arg Glu Leu Leu Asp 145 150 155 160 Ala Ser Gln His Ser Val Ala Thr Thr Pro Ala Gly Val Pro Ala Glu 165 170 175 Pro Gly Val Gly Glu Thr Val Val Val Glu Ser Ala Gly Asp Val Leu 180 185 190 Val Pro Gln Ile Pro Val Gln Arg Thr Leu Ala Ser Thr Ala Leu Ser 195 200 205 Leu Ala Thr Ile Ile Thr Ala Ile Gly Ile Val Ile Leu Leu Phe Val 210 215 220 Pro Phe Gly Val Ser Ile Ala Val Pro Phe Phe Val Gly Met Val Pro 225 230 235 240 Ala Val Trp Asn Leu Ile Asp Lys Ser Trp Gln Phe Thr Ala Thr Gln 245 250 255 Arg Asn Asp Val Leu His Val Ser Tyr Gly Leu Ala Asn Arg Arg Lys 260 265 270 Gln Ser Ile Pro Leu Gly Arg Ile His Ala Val Lys Leu Lys Gln Pro 275 280 285 Leu Leu Trp Arg Leu Val Gly Trp Trp Thr Val Thr Val Thr Val Val 290 295 300 Gly Tyr Gly Asp Thr Thr Gln Gly Gly Thr Ser Lys Ile Leu Pro Val 305 310 315 320 Gly Ser Lys Glu Leu Ala Leu Lys Val Leu Glu Ala Val Gly Pro Leu 325 330 335 Asn Ser Ala Asp Ile Ala Glu Ser Ala Asp Pro Ser His Met Ser Arg 340 345 350 Pro Gln Tyr Thr Pro Pro Val Ala Ala Arg Leu Leu Thr Pro Val Asp 355 360 365 Arg Thr Arg Gln Gly Val Thr Leu Ile Gly Val Ala Gly Ala Pro Gly 370 375 380 Ala Val Val Val His Glu Gly Arg Phe Met Pro Arg Met Ser Val Ile 385 390 395 400 Asp Thr Ser His Ile Gln Glu Leu Thr Leu Lys His Gly Pro Ile Gln 405 410 415 Arg Ile Leu Gly Leu Ser Thr Val Val Phe Asn Leu Val Gln Gly Pro 420 425 430 Val Gly Met Ala Ala Ser Asp Leu Ser Ala Ala Asp Gly Lys Glu Leu 435 440 445 Leu Asn Ile Leu Arg Asn Arg Lys Leu Pro Ala Leu Glu Ser Ala Pro 450 455 460 Leu Gly Gln Asn Ser Leu Asp 465 470 <210> 45 <211> 2161 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2131) <223> RXA00416 <400> 45 caagctctga aagcagatag cacgtgagac tcattaatac atacttgtaa ttttgctcct 60 cgatcccagc aatgctcgtt gagtatgaaa gacttctatc atg att aac acc tct 115 Met Ile Asn Thr Ser 1 5 gaa gat gaa ggt gca gtc gtg gtt cat gag gat ttg aat cct tat ggt 163 Glu Asp Glu Gly Ala Val Val Val His Glu Asp Leu Asn Pro Tyr Gly 10 15 20 cca tca cgt gtg cct gaa ggc gaa gtg tat cgg cct gat cgt cta aac 211 Pro Ser Arg Val Pro Glu Gly Glu Val Tyr Arg Pro Asp Arg Leu Asn 25 30 35 agg aaa gct aca ctt gtt gca att gtg gga gct gcc atc ctg gct ttc 259 Arg Lys Ala Thr Leu Val Ala Ile Val Gly Ala Ala Ile Leu Ala Phe 40 45 50 gca ttt gct ttg gtg ttg tgg atg ggt tta aaa caa aca aac ctt cca 307 Ala Phe Ala Leu Val Leu Trp Met Gly Leu Lys Gln Thr Asn Leu Pro 55 60 65 gct ttc ggc cca tcg aat gtc acg agg gct gtt gct tct gcc acc atc 355 Ala Phe Gly Pro Ser Asn Val Thr Arg Ala Val Ala Ser Ala Thr Ile 70 75 80 85 gct gcg gtt ttg att gtc acg ggt ttt ttg acg tgg ctg tgg ctg cgc 403 Ala Ala Val Leu Ile Val Thr Gly Phe Leu Thr Trp Leu Trp Leu Arg 90 95 100 gat gaa cat cag agc aat ccg cgg tgg gag ttg gag gac gtc aag cca 451 Asp Glu His Gln Ser Asn Pro Arg Trp Glu Leu Glu Asp Val Lys Pro 105 110 115 agg ccc aag tgg cgg acg gcg ctg acg tat ctg gcg tct tac tta agc 499 Arg Pro Lys Trp Arg Thr Ala Leu Thr Tyr Leu Ala Ser Tyr Leu Ser 120 125 130 cca gct gcg ctg gtg gtt gcg gtg ttg gct att ccg ctg tct gcg acc 547 Pro Ala Ala Leu Val Val Ala Val Leu Ala Ile Pro Leu Ser Ala Thr 135 140 145 cgc ctg tat ttg gac gga atc agc gtt gac cag ggc ttt aga act cag 595 Arg Leu Tyr Leu Asp Gly Ile Ser Val Asp Gln Gly Phe Arg Thr Gln 150 155 160 165 ttt tta acc cgc atg gct gac gat atc ggc ttg tcg gac atg aac tac 643 Phe Leu Thr Arg Met Ala Asp Asp Ile Gly Leu Ser Asp Met Asn Tyr 170 175 180 atc gat atg cct acc ttc tac cct gct gga tgg ttc tgg ctc ggt ggt 691 Ile Asp Met Pro Thr Phe Tyr Pro Ala Gly Trp Phe Trp Leu Gly Gly 185 190 195 cgc ttg gcc aat ctt ttg ggg ctg ccc ggt tgg gaa gct ttc cag cca 739 Arg Leu Ala Asn Leu Leu Gly Leu Pro Gly Trp Glu Ala Phe Gln Pro 200 205 210 tgg gca att gtg tcc atg gca gtt gct gct tct gtg tta gtt cca gtg 787 Trp Ala Ile Val Ser Met Ala Val Ala Ala Ser Val Leu Val Pro Val 215 220 225 tgg cag cgc atc acc ggt tcc ctg ccg gtg gca aca ggc att gcg ttg 835 Trp Gln Arg Ile Thr Gly Ser Leu Pro Val Ala Thr Gly Ile Ala Leu 230 235 240 245 gtg aca acc tgc att atc ttg gcg atg aat tcc gaa gag ccc tac gct 883 Val Thr Thr Cys Ile Ile Leu Ala Met Asn Ser Glu Glu Pro Tyr Ala 250 255 260 gca atc gtt gcg atg ggt att cca gcg atg ctc gtg ctg gct tcc cgc 931 Ala Ile Val Ala Met Gly Ile Pro Ala Met Leu Val Leu Ala Ser Arg 265 270 275 att gcc aag ggc gat aag ttt gcg ctt gcc ggc ggc att att tac ttg 979 Ile Ala Lys Gly Asp Lys Phe Ala Leu Ala Gly Gly Ile Ile Tyr Leu 280 285 290 ggt gtt tcg gct act ttc tat act ttg ttc acc ggt gct atc gcg ctt 1027 Gly Val Ser Ala Thr Phe Tyr Thr Leu Phe Thr Gly Ala Ile Ala Leu 295 300 305 tct gcg gtc gcg gtg tgc atc gtg gtg gcg gct att gtg cag cgc tcc 1075 Ser Ala Val Ala Val Cys Ile Val Val Ala Ala Ile Val Gln Arg Ser 310 315 320 325 atc aaa cca ctg ctg tgg ctt gca gtg ctg ggt ggt gga tcc att gtc 1123 Ile Lys Pro Leu Leu Trp Leu Ala Val Leu Gly Gly Gly Ser Ile Val 330 335 340 att gcg ttg att tct tgg ggt cct tac ctt ctg gcc tcc atc aac gga 1171 Ile Ala Leu Ile Ser Trp Gly Pro Tyr Leu Leu Ala Ser Ile Asn Gly 345 350 355 gcg gag cgc tct ggc gat tcc gca aca cac tac ctg cct ctt gaa ggc 1219 Ala Glu Arg Ser Gly Asp Ser Ala Thr His Tyr Leu Pro Leu Glu Gly 360 365 370 acc caa ttc ccg gtt cct ttc ttg gca tca agc gtt gtg gga ctg ttg 1267 Thr Gln Phe Pro Val Pro Phe Leu Ala Ser Ser Val Val Gly Leu Leu 375 380 385 tgt ctt gtt ggc ctg atc tat ttg gtg gtg cgt ttc cac aac aat gag 1315 Cys Leu Val Gly Leu Ile Tyr Leu Val Val Arg Phe His Asn Asn Glu 390 395 400 405 gtg cgc gcg atg tgg gtc ggc atc gca gtg ttt tat gcc tgg atg ggc 1363 Val Arg Ala Met Trp Val Gly Ile Ala Val Phe Tyr Ala Trp Met Gly 410 415 420 atg tcc atg gcg atc acg ctt ttg ggc aac acg ttg ctt gga ttc cgt 1411 Met Ser Met Ala Ile Thr Leu Leu Gly Asn Thr Leu Leu Gly Phe Arg 425 430 435 ctt gat acg gtg ctg gtg ctt att ttt gcc acg gct gga gtg ttg ggc 1459 Leu Asp Thr Val Leu Val Leu Ile Phe Ala Thr Ala Gly Val Leu Gly 440 445 450 att gca gat ttc cgc ctt gcc agt gtg tat cag ctc tac ccc acc caa 1507 Ile Ala Asp Phe Arg Leu Ala Ser Val Tyr Gln Leu Tyr Pro Thr Gln 455 460 465 atc aca gag cgc acg gcc acc cat ctg acc aat cta att gtg gtc ctc 1555 Ile Thr Glu Arg Thr Ala Thr His Leu Thr Asn Leu Ile Val Val Leu 470 475 480 485 gtg ctg ctt ggc ggc ctc tac tac gcg caa gat ctg ccg cag aag aac 1603 Val Leu Leu Gly Gly Leu Tyr Tyr Ala Gln Asp Leu Pro Gln Lys Asn 490 495 500 gca cga gct atc gat ctg gcc tat acc gat act gat ggc tac ggc gag 1651 Ala Arg Ala Ile Asp Leu Ala Tyr Thr Asp Thr Asp Gly Tyr Gly Glu 505 510 515 cgc gcg gat ctg tat ccg gcc gga gct gca cgt tat tac aag gac atc 1699 Arg Ala Asp Leu Tyr Pro Ala Gly Ala Ala Arg Tyr Tyr Lys Asp Ile 520 525 530 aac gat cat ctg ctt gat caa gga ttc gag cct tcc gaa act gtc gtg 1747 Asn Asp His Leu Leu Asp Gln Gly Phe Glu Pro Ser Glu Thr Val Val 535 540 545 ctg aca gac gaa ctc gat ttc atg tcc tac tac cct tat cgc gga tac 1795 Leu Thr Asp Glu Leu Asp Phe Met Ser Tyr Tyr Pro Tyr Arg Gly Tyr 550 555 560 565 caa gct ttt act tcc cac tac gcc aac ccg ctt ggt gag ttc gga aac 1843 Gln Ala Phe Thr Ser His Tyr Ala Asn Pro Leu Gly Glu Phe Gly Asn 570 575 580 agg aac gca ttc atc gaa gat ctc gcg atc cga agc tgg gat gag ttg 1891 Arg Asn Ala Phe Ile Glu Asp Leu Ala Ile Arg Ser Trp Asp Glu Leu 585 590 595 gct gat cct caa caa ttc agc gac gcc ttg aac acc tct cca tgg acg 1939 Ala Asp Pro Gln Gln Phe Ser Asp Ala Leu Asn Thr Ser Pro Trp Thr 600 605 610 atc cct gag gtg ttc atc ttc cgt ggc tcc atc gat gat cct gac gcc 1987 Ile Pro Glu Val Phe Ile Phe Arg Gly Ser Ile Asp Asp Pro Asp Ala 615 620 625 ggt tgg aaa tac gac gtg gct gaa gat ctg tac ccg aac aat cca aac 2035 Gly Trp Lys Tyr Asp Val Ala Glu Asp Leu Tyr Pro Asn Asn Pro Asn 630 635 640 645 gtg cgc ttc cgc ggc gtg tac ttt aac ccg gag tca ttt gat cag atg 2083 Val Arg Phe Arg Gly Val Tyr Phe Asn Pro Glu Ser Phe Asp Gln Met 650 655 660 tgg cag acc aag caa gtg gga cct ttc gtg gtg gta acg cac aat gag 2131 Trp Gln Thr Lys Gln Val Gly Pro Phe Val Val Val Thr His Asn Glu 665 670 675 taattcctca ccaaacgacc caagccctat 2161 <210> 46 <211> 677 <212> PRT <213> Corynebacterium glutamicum <400> 46 Met Ile Asn Thr Ser Glu Asp Glu Gly Ala Val Val Val His Glu Asp 1 5 10 15 Leu Asn Pro Tyr Gly Pro Ser Arg Val Pro Glu Gly Glu Val Tyr Arg 20 25 30 Pro Asp Arg Leu Asn Arg Lys Ala Thr Leu Val Ala Ile Val Gly Ala 35 40 45 Ala Ile Leu Ala Phe Ala Phe Ala Leu Val Leu Trp Met Gly Leu Lys 50 55 60 Gln Thr Asn Leu Pro Ala Phe Gly Pro Ser Asn Val Thr Arg Ala Val 65 70 75 80 Ala Ser Ala Thr Ile Ala Ala Val Leu Ile Val Thr Gly Phe Leu Thr 85 90 95 Trp Leu Trp Leu Arg Asp Glu His Gln Ser Asn Pro Arg Trp Glu Leu 100 105 110 Glu Asp Val Lys Pro Arg Pro Lys Trp Arg Thr Ala Leu Thr Tyr Leu 115 120 125 Ala Ser Tyr Leu Ser Pro Ala Ala Leu Val Val Ala Val Leu Ala Ile 130 135 140 Pro Leu Ser Ala Thr Arg Leu Tyr Leu Asp Gly Ile Ser Val Asp Gln 145 150 155 160 Gly Phe Arg Thr Gln Phe Leu Thr Arg Met Ala Asp Asp Ile Gly Leu 165 170 175 Ser Asp Met Asn Tyr Ile Asp Met Pro Thr Phe Tyr Pro Ala Gly Trp 180 185 190 Phe Trp Leu Gly Gly Arg Leu Ala Asn Leu Leu Gly Leu Pro Gly Trp 195 200 205 Glu Ala Phe Gln Pro Trp Ala Ile Val Ser Met Ala Val Ala Ala Ser 210 215 220 Val Leu Val Pro Val Trp Gln Arg Ile Thr Gly Ser Leu Pro Val Ala 225 230 235 240 Thr Gly Ile Ala Leu Val Thr Thr Cys Ile Ile Leu Ala Met Asn Ser 245 250 255 Glu Glu Pro Tyr Ala Ala Ile Val Ala Met Gly Ile Pro Ala Met Leu 260 265 270 Val Leu Ala Ser Arg Ile Ala Lys Gly Asp Lys Phe Ala Leu Ala Gly 275 280 285 Gly Ile Ile Tyr Leu Gly Val Ser Ala Thr Phe Tyr Thr Leu Phe Thr 290 295 300 Gly Ala Ile Ala Leu Ser Ala Val Ala Val Cys Ile Val Val Ala Ala 305 310 315 320 Ile Val Gln Arg Ser Ile Lys Pro Leu Leu Trp Leu Ala Val Leu Gly 325 330 335 Gly Gly Ser Ile Val Ile Ala Leu Ile Ser Trp Gly Pro Tyr Leu Leu 340 345 350 Ala Ser Ile Asn Gly Ala Glu Arg Ser Gly Asp Ser Ala Thr His Tyr 355 360 365 Leu Pro Leu Glu Gly Thr Gln Phe Pro Val Pro Phe Leu Ala Ser Ser 370 375 380 Val Val Gly Leu Leu Cys Leu Val Gly Leu Ile Tyr Leu Val Val Arg 385 390 395 400 Phe His Asn Asn Glu Val Arg Ala Met Trp Val Gly Ile Ala Val Phe 405 410 415 Tyr Ala Trp Met Gly Met Ser Met Ala Ile Thr Leu Leu Gly Asn Thr 420 425 430 Leu Leu Gly Phe Arg Leu Asp Thr Val Leu Val Leu Ile Phe Ala Thr 435 440 445 Ala Gly Val Leu Gly Ile Ala Asp Phe Arg Leu Ala Ser Val Tyr Gln 450 455 460 Leu Tyr Pro Thr Gln Ile Thr Glu Arg Thr Ala Thr His Leu Thr Asn 465 470 475 480 Leu Ile Val Val Leu Val Leu Leu Gly Gly Leu Tyr Tyr Ala Gln Asp 485 490 495 Leu Pro Gln Lys Asn Ala Arg Ala Ile Asp Leu Ala Tyr Thr Asp Thr 500 505 510 Asp Gly Tyr Gly Glu Arg Ala Asp Leu Tyr Pro Ala Gly Ala Ala Arg 515 520 525 Tyr Tyr Lys Asp Ile Asn Asp His Leu Leu Asp Gln Gly Phe Glu Pro 530 535 540 Ser Glu Thr Val Val Leu Thr Asp Glu Leu Asp Phe Met Ser Tyr Tyr 545 550 555 560 Pro Tyr Arg Gly Tyr Gln Ala Phe Thr Ser His Tyr Ala Asn Pro Leu 565 570 575 Gly Glu Phe Gly Asn Arg Asn Ala Phe Ile Glu Asp Leu Ala Ile Arg 580 585 590 Ser Trp Asp Glu Leu Ala Asp Pro Gln Gln Phe Ser Asp Ala Leu Asn 595 600 605 Thr Ser Pro Trp Thr Ile Pro Glu Val Phe Ile Phe Arg Gly Ser Ile 610 615 620 Asp Asp Pro Asp Ala Gly Trp Lys Tyr Asp Val Ala Glu Asp Leu Tyr 625 630 635 640 Pro Asn Asn Pro Asn Val Arg Phe Arg Gly Val Tyr Phe Asn Pro Glu 645 650 655 Ser Phe Asp Gln Met Trp Gln Thr Lys Gln Val Gly Pro Phe Val Val 660 665 670 Val Thr His Asn Glu 675 <210> 47 <211> 619 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(589) <223> RXA00424 <400> 47 aggttggtgc gttccgccgc gatgtggacc tcgggagcct tggctttttt gaatctttca 60 aacatgccca ccaccttaat cagtgagtag tcttggcaac atg gat acc agg atg 115 Met Asp Thr Arg Met 1 5 aga ttg cag gta gca gca ggt tcc gcg ctg att ggt gct ggg gtt gcg 163 Arg Leu Gln Val Ala Ala Gly Ser Ala Leu Ile Gly Ala Gly Val Ala 10 15 20 gtt aat gat tac gta caa agc cca gtc cgc cgg gcc atc agt tat ggt 211 Val Asn Asp Tyr Val Gln Ser Pro Val Arg Arg Ala Ile Ser Tyr Gly 25 30 35 gcg ttg gcg ctt tct ggg gcg acg gtg att gcg atg ggt cag gac ccg 259 Ala Leu Ala Leu Ser Gly Ala Thr Val Ile Ala Met Gly Gln Asp Pro 40 45 50 act ggg gag cgg tcc atc att gcg aaa gat tcc gcg acg atg gtt gat 307 Thr Gly Glu Arg Ser Ile Ile Ala Lys Asp Ser Ala Thr Met Val Asp 55 60 65 caa atc cgc cag gag atc ggc gat ttg ggt gtc acg cct ggt cca gaa 355 Gln Ile Arg Gln Glu Ile Gly Asp Leu Gly Val Thr Pro Gly Pro Glu 70 75 80 85 tct gat gtg gat gcc atc acg gag cga ggt ccg ctg gtg acg tgg ctg 403 Ser Asp Val Asp Ala Ile Thr Glu Arg Gly Pro Leu Val Thr Trp Leu 90 95 100 ttg ctt gct gtt ttt gtc gtg gca ttt ttc acc ttg gcg tat ttc tcc 451 Leu Leu Ala Val Phe Val Val Ala Phe Phe Thr Leu Ala Tyr Phe Ser 105 110 115 atg cgc atg gat gtg gcg gtg atg aga agg atc gct aag ttc ttt gaa 499 Met Arg Met Asp Val Ala Val Met Arg Arg Ile Ala Lys Phe Phe Glu 120 125 130 aaa cgt ggc gct tcc agg cca ttc acc tgc act ggc atg gtg tac gcc 547 Lys Arg Gly Ala Ser Arg Pro Phe Thr Cys Thr Gly Met Val Tyr Ala 135 140 145 gct ttt att tac gca atc tgt gag ctg gag gcc cgc aca aaa 589 Ala Phe Ile Tyr Ala Ile Cys Glu Leu Glu Ala Arg Thr Lys 150 155 160 tgacctatcc cgtgttgagt gttttggata 619 <210> 48 <211> 163 <212> PRT <213> Corynebacterium glutamicum <400> 48 Met Asp Thr Arg Met Arg Leu Gln Val Ala Ala Gly Ser Ala Leu Ile 1 5 10 15 Gly Ala Gly Val Ala Val Asn Asp Tyr Val Gln Ser Pro Val Arg Arg 20 25 30 Ala Ile Ser Tyr Gly Ala Leu Ala Leu Ser Gly Ala Thr Val Ile Ala 35 40 45 Met Gly Gln Asp Pro Thr Gly Glu Arg Ser Ile Ile Ala Lys Asp Ser 50 55 60 Ala Thr Met Val Asp Gln Ile Arg Gln Glu Ile Gly Asp Leu Gly Val 65 70 75 80 Thr Pro Gly Pro Glu Ser Asp Val Asp Ala Ile Thr Glu Arg Gly Pro 85 90 95 Leu Val Thr Trp Leu Leu Leu Ala Val Phe Val Val Ala Phe Phe Thr 100 105 110 Leu Ala Tyr Phe Ser Met Arg Met Asp Val Ala Val Met Arg Arg Ile 115 120 125 Ala Lys Phe Phe Glu Lys Arg Gly Ala Ser Arg Pro Phe Thr Cys Thr 130 135 140 Gly Met Val Tyr Ala Ala Phe Ile Tyr Ala Ile Cys Glu Leu Glu Ala 145 150 155 160 Arg Thr Lys <210> 49 <211> 652 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(622) <223> RXA00451 <400> 49 gtggttggct gcatggaggt cgcggaggag ggatccgccg atgaggccga ggcccaggat 60 gcatactggg cgggaaatgt ctttggtagt cacctgacaa gtg tgg cac ata cct 115 Val Trp His Ile Pro 1 5 act acg gtt atc tct atg aac act gaa gag gat ggc ctg agc ttt gca 163 Thr Thr Val Ile Ser Met Asn Thr Glu Glu Asp Gly Leu Ser Phe Ala 10 15 20 gtt acg gct acc tta gtt gaa ggt aaa tgg cag gta cgc gag ttt gag 211 Val Thr Ala Thr Leu Val Glu Gly Lys Trp Gln Val Arg Glu Phe Glu 25 30 35 gat cac ttc tcc aag ctc tct acc tct att aat gcg gtt cgc tcg ctg 259 Asp His Phe Ser Lys Leu Ser Thr Ser Ile Asn Ala Val Arg Ser Leu 40 45 50 cgt agc gag ggg ccg gcg ttt gcg ctg ttg tgc gtt gat gat gaa tat 307 Arg Ser Glu Gly Pro Ala Phe Ala Leu Leu Cys Val Asp Asp Glu Tyr 55 60 65 ttt gtg atg gtg cgt ccc acc cca agt agg gta ttc ctt ttc ctt tcg 355 Phe Val Met Val Arg Pro Thr Pro Ser Arg Val Phe Leu Phe Leu Ser 70 75 80 85 gat gcg ccg atg gct gtc gac gat gat ttc gcc gcc gcg gtg atg gat 403 Asp Ala Pro Met Ala Val Asp Asp Asp Phe Ala Ala Ala Val Met Asp 90 95 100 gaa ctc gat gcg gat ctt cca gat atc aac cct gat gat ttg gac gac 451 Glu Leu Asp Ala Asp Leu Pro Asp Ile Asn Pro Asp Asp Leu Asp Asp 105 110 115 atc gat cca tgg cca gaa ggt gat ttc gat att ttg gcg gat ttg ggg 499 Ile Asp Pro Trp Pro Glu Gly Asp Phe Asp Ile Leu Ala Asp Leu Gly 120 125 130 ctg tct gag gag gtt ctt tcc gtg att tgc gat gac atg gat ttg gat 547 Leu Ser Glu Glu Val Leu Ser Val Ile Cys Asp Asp Met Asp Leu Asp 135 140 145 cct tcc gaa caa ttg ctg cgc atc gcg gaa gaa ctc ggt ttt gat aat 595 Pro Ser Glu Gln Leu Leu Arg Ile Ala Glu Glu Leu Gly Phe Asp Asn 150 155 160 165 gat ctg gct cgg gtg gtg gga ttc gac tagtgggcgt tttacctgtg 642 Asp Leu Ala Arg Val Val Gly Phe Asp 170 caggcgcgca 652 <210> 50 <211> 174 <212> PRT <213> Corynebacterium glutamicum <400> 50 Val Trp His Ile Pro Thr Thr Val Ile Ser Met Asn Thr Glu Glu Asp 1 5 10 15 Gly Leu Ser Phe Ala Val Thr Ala Thr Leu Val Glu Gly Lys Trp Gln 20 25 30 Val Arg Glu Phe Glu Asp His Phe Ser Lys Leu Ser Thr Ser Ile Asn 35 40 45 Ala Val Arg Ser Leu Arg Ser Glu Gly Pro Ala Phe Ala Leu Leu Cys 50 55 60 Val Asp Asp Glu Tyr Phe Val Met Val Arg Pro Thr Pro Ser Arg Val 65 70 75 80 Phe Leu Phe Leu Ser Asp Ala Pro Met Ala Val Asp Asp Asp Phe Ala 85 90 95 Ala Ala Val Met Asp Glu Leu Asp Ala Asp Leu Pro Asp Ile Asn Pro 100 105 110 Asp Asp Leu Asp Asp Ile Asp Pro Trp Pro Glu Gly Asp Phe Asp Ile 115 120 125 Leu Ala Asp Leu Gly Leu Ser Glu Glu Val Leu Ser Val Ile Cys Asp 130 135 140 Asp Met Asp Leu Asp Pro Ser Glu Gln Leu Leu Arg Ile Ala Glu Glu 145 150 155 160 Leu Gly Phe Asp Asn Asp Leu Ala Arg Val Val Gly Phe Asp 165 170 <210> 51 <211> 991 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(961) <223> RXA00476 <400> 51 gtgaacgaat tgttgtaatt cgtcttaaaa acgccaggag acgtgaaaat tacagacacc 60 ccagacatca gatggaggcg gcgatactag ggtagaggac atg act ctt cgc tgt 115 Met Thr Leu Arg Cys 1 5 tct gac gtc aat gtt gaa ccc ctg ccg gga acg gca aaa aca ggt tct 163 Ser Asp Val Asn Val Glu Pro Leu Pro Gly Thr Ala Lys Thr Gly Ser 10 15 20 ggg ttt gtt ctc ctt gaa cat gct ggc tcg tgg agc cgt gat gtt tta 211 Gly Phe Val Leu Leu Glu His Ala Gly Ser Trp Ser Arg Asp Val Leu 25 30 35 gac ggc gga aca ttt gat cct gag ttg act gat caa ttg aag agg cac 259 Asp Gly Gly Thr Phe Asp Pro Glu Leu Thr Asp Gln Leu Lys Arg His 40 45 50 ctg aaa gct tcc gga atg ggt ctg caa tta att agg aag ccg gga agg 307 Leu Lys Ala Ser Gly Met Gly Leu Gln Leu Ile Arg Lys Pro Gly Arg 55 60 65 gag ggt cga aac gtc gaa aag cat aat ctt ttt ctc gtt ttt gct gag 355 Glu Gly Arg Asn Val Glu Lys His Asn Leu Phe Leu Val Phe Ala Glu 70 75 80 85 gcc tca att att gag cac ctg gtg gtg gac gcg ccg gct gat gtt ttg 403 Ala Ser Ile Ile Glu His Leu Val Val Asp Ala Pro Ala Asp Val Leu 90 95 100 gat ctt gat tta agc ggg ccg ggc aaa aac aat gcg cag cgc atg gat 451 Asp Leu Asp Leu Ser Gly Pro Gly Lys Asn Asn Ala Gln Arg Met Asp 105 110 115 gat ccg atg ctg ctg att tgt acg cat tcg aag cgc gat gtg tgc tgc 499 Asp Pro Met Leu Leu Ile Cys Thr His Ser Lys Arg Asp Val Cys Cys 120 125 130 gcg atc aag ggg cgt ccg ctg gca gct gcc gtg gag cca caa ttt ggg 547 Ala Ile Lys Gly Arg Pro Leu Ala Ala Ala Val Glu Pro Gln Phe Gly 135 140 145 ccg ctg cat gtg tgg gag gct tcg cac acc aag ggc cac cgt ttt gcg 595 Pro Leu His Val Trp Glu Ala Ser His Thr Lys Gly His Arg Phe Ala 150 155 160 165 cca tcg atg ctg ctc atg ccg tgg aat tac tct tat ggc cta ctt gat 643 Pro Ser Met Leu Leu Met Pro Trp Asn Tyr Ser Tyr Gly Leu Leu Asp 170 175 180 gag gcc gaa acc gtg cag ctt ttc caa ggc gcg ttg gac aac aaa ctc 691 Glu Ala Glu Thr Val Gln Leu Phe Gln Gly Ala Leu Asp Asn Lys Leu 185 190 195 ttc ctg ccg ggc aac cgt ggc cga gga acc tta gat gct cgt ggc cag 739 Phe Leu Pro Gly Asn Arg Gly Arg Gly Thr Leu Asp Ala Arg Gly Gln 200 205 210 gtt gca gaa att gcc gtg gcg gaa gct ttc ggc gag gcg gtt gct cct 787 Val Ala Glu Ile Ala Val Ala Glu Ala Phe Gly Glu Ala Val Ala Pro 215 220 225 gcg agt ttg cag gtt gaa ttc gaa gat gat tct gtt ttg gtt act cat 835 Ala Ser Leu Gln Val Glu Phe Glu Asp Asp Ser Val Leu Val Thr His 230 235 240 245 ccc gat ggg cgc acg tgg gtt gtg gag ctt gaa cgc atc gag gtc gac 883 Pro Asp Gly Arg Thr Trp Val Val Glu Leu Glu Arg Ile Glu Val Asp 250 255 260 ggc gtg gtg tcc tcg tgt ggt gat cag ccg aaa act gga aaa gcg tgg 931 Gly Val Val Ser Ser Cys Gly Asp Gln Pro Lys Thr Gly Lys Ala Trp 265 270 275 gtg gct agg caa gtt aca gaa ctg atc gga taaaagcaga gttatatctg 981 Val Ala Arg Gln Val Thr Glu Leu Ile Gly 280 285 atgaattgct 991 <210> 52 <211> 287 <212> PRT <213> Corynebacterium glutamicum <400> 52 Met Thr Leu Arg Cys Ser Asp Val Asn Val Glu Pro Leu Pro Gly Thr 1 5 10 15 Ala Lys Thr Gly Ser Gly Phe Val Leu Leu Glu His Ala Gly Ser Trp 20 25 30 Ser Arg Asp Val Leu Asp Gly Gly Thr Phe Asp Pro Glu Leu Thr Asp 35 40 45 Gln Leu Lys Arg His Leu Lys Ala Ser Gly Met Gly Leu Gln Leu Ile 50 55 60 Arg Lys Pro Gly Arg Glu Gly Arg Asn Val Glu Lys His Asn Leu Phe 65 70 75 80 Leu Val Phe Ala Glu Ala Ser Ile Ile Glu His Leu Val Val Asp Ala 85 90 95 Pro Ala Asp Val Leu Asp Leu Asp Leu Ser Gly Pro Gly Lys Asn Asn 100 105 110 Ala Gln Arg Met Asp Asp Pro Met Leu Leu Ile Cys Thr His Ser Lys 115 120 125 Arg Asp Val Cys Cys Ala Ile Lys Gly Arg Pro Leu Ala Ala Ala Val 130 135 140 Glu Pro Gln Phe Gly Pro Leu His Val Trp Glu Ala Ser His Thr Lys 145 150 155 160 Gly His Arg Phe Ala Pro Ser Met Leu Leu Met Pro Trp Asn Tyr Ser 165 170 175 Tyr Gly Leu Leu Asp Glu Ala Glu Thr Val Gln Leu Phe Gln Gly Ala 180 185 190 Leu Asp Asn Lys Leu Phe Leu Pro Gly Asn Arg Gly Arg Gly Thr Leu 195 200 205 Asp Ala Arg Gly Gln Val Ala Glu Ile Ala Val Ala Glu Ala Phe Gly 210 215 220 Glu Ala Val Ala Pro Ala Ser Leu Gln Val Glu Phe Glu Asp Asp Ser 225 230 235 240 Val Leu Val Thr His Pro Asp Gly Arg Thr Trp Val Val Glu Leu Glu 245 250 255 Arg Ile Glu Val Asp Gly Val Val Ser Ser Cys Gly Asp Gln Pro Lys 260 265 270 Thr Gly Lys Ala Trp Val Ala Arg Gln Val Thr Glu Leu Ile Gly 275 280 285 <210> 53 <211> 1039 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1009) <223> RXA00486 <400> 53 gtttattcat gcccttgatt attgccaaag aaacctttaa ggactagatc gaaaaacagc 60 caactatagt taagtaatac tgaacaattt tggaggtgtc gtg ctc aat ctc aac 115 Val Leu Asn Leu Asn 1 5 cgc tta cac atc ctg cag gaa ttc cac cgc ctg gga acg att aca gca 163 Arg Leu His Ile Leu Gln Glu Phe His Arg Leu Gly Thr Ile Thr Ala 10 15 20 gtg gcg gaa tcc atg aac tac agc cgc tct gcc atc tcc caa caa atg 211 Val Ala Glu Ser Met Asn Tyr Ser Arg Ser Ala Ile Ser Gln Gln Met 25 30 35 gcg ctg ctg gaa aaa gaa att ggt gtg aaa ctc ttt gaa aaa agc ggc 259 Ala Leu Leu Glu Lys Glu Ile Gly Val Lys Leu Phe Glu Lys Ser Gly 40 45 50 cga aac ctc tac ttc aca gaa caa ggc gaa gtg ttg gcc tca gaa aca 307 Arg Asn Leu Tyr Phe Thr Glu Gln Gly Glu Val Leu Ala Ser Glu Thr 55 60 65 cat gcg atc atg gca gca gtc gac cat gcc cgc gca gcc gtt cta gat 355 His Ala Ile Met Ala Ala Val Asp His Ala Arg Ala Ala Val Leu Asp 70 75 80 85 tcg ctg tct gaa gtg tcc gga acg ctg aaa gtc acc tcc ttc caa tcc 403 Ser Leu Ser Glu Val Ser Gly Thr Leu Lys Val Thr Ser Phe Gln Ser 90 95 100 ctg ctg ttc acc ctt gcc ccg aaa gcc atc gcg cgc ctg acc gag aaa 451 Leu Leu Phe Thr Leu Ala Pro Lys Ala Ile Ala Arg Leu Thr Glu Lys 105 110 115 tac cca cac ctg caa gta gaa atc tcc caa cta gaa gtc acc gca gcg 499 Tyr Pro His Leu Gln Val Glu Ile Ser Gln Leu Glu Val Thr Ala Ala 120 125 130 ctc gaa gaa ctc cgc gcc cgc cgc gtc gac gtc gca ctc ggc gag gaa 547 Leu Glu Glu Leu Arg Ala Arg Arg Val Asp Val Ala Leu Gly Glu Glu 135 140 145 tac ccc gtg gaa gtc ccc ctt gtt gag gcc agc att cac cgc gaa gtc 595 Tyr Pro Val Glu Val Pro Leu Val Glu Ala Ser Ile His Arg Glu Val 150 155 160 165 ctc ttc gaa gac ccc atg ctg ctc gtc acc cca gca agc ggc cca tac 643 Leu Phe Glu Asp Pro Met Leu Leu Val Thr Pro Ala Ser Gly Pro Tyr 170 175 180 tct ggc ctc acc ctg cca gaa ctc cgc gac atc ccc atc gcc atc gat 691 Ser Gly Leu Thr Leu Pro Glu Leu Arg Asp Ile Pro Ile Ala Ile Asp 185 190 195 cca ccc gac ctt ccc gcg ggc gaa tgg gtc cat agg ctc tgc cgg cgc 739 Pro Pro Asp Leu Pro Ala Gly Glu Trp Val His Arg Leu Cys Arg Arg 200 205 210 gcc ggg ttt gag ccc cgc gtg acc ttt gaa acc agc gat ccc atg ctc 787 Ala Gly Phe Glu Pro Arg Val Thr Phe Glu Thr Ser Asp Pro Met Leu 215 220 225 caa gca cac ctc gtg cgt agc ggc ttg gcc gtg aca ttt tcc ccc aca 835 Gln Ala His Leu Val Arg Ser Gly Leu Ala Val Thr Phe Ser Pro Thr 230 235 240 245 ctg ctc acc ccg atg ctg gaa agc gtg cac atc cag ccg ctg ccc ggc 883 Leu Leu Thr Pro Met Leu Glu Ser Val His Ile Gln Pro Leu Pro Gly 250 255 260 aac ccc acg cgc acg ctc tac acc gcg gtc agg gaa ggg cgc cag ggg 931 Asn Pro Thr Arg Thr Leu Tyr Thr Ala Val Arg Glu Gly Arg Gln Gly 265 270 275 cat cca gcc att aaa gct ttt cga cga gcc ctc gcc cat gtg gcc aaa 979 His Pro Ala Ile Lys Ala Phe Arg Arg Ala Leu Ala His Val Ala Lys 280 285 290 gaa tct tat ttg gag gct cgt cta gta gag tgagttcttg tgagccttca 1029 Glu Ser Tyr Leu Glu Ala Arg Leu Val Glu 295 300 gacaaatcat 1039 <210> 54 <211> 303 <212> PRT <213> Corynebacterium glutamicum <400> 54 Val Leu Asn Leu Asn Arg Leu His Ile Leu Gln Glu Phe His Arg Leu 1 5 10 15 Gly Thr Ile Thr Ala Val Ala Glu Ser Met Asn Tyr Ser Arg Ser Ala 20 25 30 Ile Ser Gln Gln Met Ala Leu Leu Glu Lys Glu Ile Gly Val Lys Leu 35 40 45 Phe Glu Lys Ser Gly Arg Asn Leu Tyr Phe Thr Glu Gln Gly Glu Val 50 55 60 Leu Ala Ser Glu Thr His Ala Ile Met Ala Ala Val Asp His Ala Arg 65 70 75 80 Ala Ala Val Leu Asp Ser Leu Ser Glu Val Ser Gly Thr Leu Lys Val 85 90 95 Thr Ser Phe Gln Ser Leu Leu Phe Thr Leu Ala Pro Lys Ala Ile Ala 100 105 110 Arg Leu Thr Glu Lys Tyr Pro His Leu Gln Val Glu Ile Ser Gln Leu 115 120 125 Glu Val Thr Ala Ala Leu Glu Glu Leu Arg Ala Arg Arg Val Asp Val 130 135 140 Ala Leu Gly Glu Glu Tyr Pro Val Glu Val Pro Leu Val Glu Ala Ser 145 150 155 160 Ile His Arg Glu Val Leu Phe Glu Asp Pro Met Leu Leu Val Thr Pro 165 170 175 Ala Ser Gly Pro Tyr Ser Gly Leu Thr Leu Pro Glu Leu Arg Asp Ile 180 185 190 Pro Ile Ala Ile Asp Pro Pro Asp Leu Pro Ala Gly Glu Trp Val His 195 200 205 Arg Leu Cys Arg Arg Ala Gly Phe Glu Pro Arg Val Thr Phe Glu Thr 210 215 220 Ser Asp Pro Met Leu Gln Ala His Leu Val Arg Ser Gly Leu Ala Val 225 230 235 240 Thr Phe Ser Pro Thr Leu Leu Thr Pro Met Leu Glu Ser Val His Ile 245 250 255 Gln Pro Leu Pro Gly Asn Pro Thr Arg Thr Leu Tyr Thr Ala Val Arg 260 265 270 Glu Gly Arg Gln Gly His Pro Ala Ile Lys Ala Phe Arg Arg Ala Leu 275 280 285 Ala His Val Ala Lys Glu Ser Tyr Leu Glu Ala Arg Leu Val Glu 290 295 300 <210> 55 <211> 1744 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1714) <223> RXA00493 <400> 55 cccgttacgg cggcaccgag atcaagttcg gtggcgtgga gtacttgctt ctctccgctc 60 gtgacatcct cgcaatcgtc gagaagtagg ggataagttc atg gca aag ctc att 115 Met Ala Lys Leu Ile 1 5 gct ttt gac cag gac gcc cgc gaa ggc att ctc cgg ggc gtt gac gct 163 Ala Phe Asp Gln Asp Ala Arg Glu Gly Ile Leu Arg Gly Val Asp Ala 10 15 20 ctg gca aac gct gtc aag gta acc ctc ggc cca cgc ggc cgt aac gtg 211 Leu Ala Asn Ala Val Lys Val Thr Leu Gly Pro Arg Gly Arg Asn Val 25 30 35 gtt ctt gat aag gca ttc ggc gga cct ctg gtc acc aac gac ggt gtc 259 Val Leu Asp Lys Ala Phe Gly Gly Pro Leu Val Thr Asn Asp Gly Val 40 45 50 acc att gcc cgc gac atc gac ctt gag gat cct ttt gag aac ctc ggt 307 Thr Ile Ala Arg Asp Ile Asp Leu Glu Asp Pro Phe Glu Asn Leu Gly 55 60 65 gcg cag ctg gtg aag tcc gtt gct gtt aag acc aac gac atc gct ggt 355 Ala Gln Leu Val Lys Ser Val Ala Val Lys Thr Asn Asp Ile Ala Gly 70 75 80 85 gac ggc acc acg act gca act ctg ctt gct cag gca ctc att gct gaa 403 Asp Gly Thr Thr Thr Ala Thr Leu Leu Ala Gln Ala Leu Ile Ala Glu 90 95 100 ggc ctg cgc aac gtt gct gct ggc gca aac cca atg gag ctc aac aag 451 Gly Leu Arg Asn Val Ala Ala Gly Ala Asn Pro Met Glu Leu Asn Lys 105 110 115 ggt att tct gca gct gca gaa aag acc ttg gaa gag ttg aag gca cgc 499 Gly Ile Ser Ala Ala Ala Glu Lys Thr Leu Glu Glu Leu Lys Ala Arg 120 125 130 gca acc gag gtg tct gac acc aag gaa atc gca aac gtc gct acc gtt 547 Ala Thr Glu Val Ser Asp Thr Lys Glu Ile Ala Asn Val Ala Thr Val 135 140 145 tca tcc cgc gat gaa gtt gtc ggc gag atc gtt gct gca gcg atg gaa 595 Ser Ser Arg Asp Glu Val Val Gly Glu Ile Val Ala Ala Ala Met Glu 150 155 160 165 aag gtt ggc aag gac ggt gtc gtc acc gtt gag gag tcc cag tcc atc 643 Lys Val Gly Lys Asp Gly Val Val Thr Val Glu Glu Ser Gln Ser Ile 170 175 180 gag act gct ctc gag gtc acc gaa ggt att tct ttc gac aag ggc tac 691 Glu Thr Ala Leu Glu Val Thr Glu Gly Ile Ser Phe Asp Lys Gly Tyr 185 190 195 ctt tcc cct tat ttc atc aac gac aac gac act cag cag gct gtc ctg 739 Leu Ser Pro Tyr Phe Ile Asn Asp Asn Asp Thr Gln Gln Ala Val Leu 200 205 210 gac aac cct gca gtg ctg ctt gtt cgc aac aag att tct tcc ctc cca 787 Asp Asn Pro Ala Val Leu Leu Val Arg Asn Lys Ile Ser Ser Leu Pro 215 220 225 gac ttc ctc cca ttg ctg gag aag gtt gtg gag tcc aac cgt cct ttg 835 Asp Phe Leu Pro Leu Leu Glu Lys Val Val Glu Ser Asn Arg Pro Leu 230 235 240 245 ctg atc atc gca gaa gac gtc gag ggc gag cct ttg cag acc ctg gtt 883 Leu Ile Ile Ala Glu Asp Val Glu Gly Glu Pro Leu Gln Thr Leu Val 250 255 260 gtg aac tcc atc cgc aag acc atc aag gtc gtt gca gtg aag tcc cct 931 Val Asn Ser Ile Arg Lys Thr Ile Lys Val Val Ala Val Lys Ser Pro 265 270 275 tac ttc ggt gac cga cgc aag gcg ttc atg gat gac ctg gct att gtc 979 Tyr Phe Gly Asp Arg Arg Lys Ala Phe Met Asp Asp Leu Ala Ile Val 280 285 290 acc aag gca act gtc gtg gat cca gaa gtg ggc atc aac ctc aac gaa 1027 Thr Lys Ala Thr Val Val Asp Pro Glu Val Gly Ile Asn Leu Asn Glu 295 300 305 gct ggc gaa gaa gtt ttc ggt acc gca cgc cgc atc acc gtt tcc aag 1075 Ala Gly Glu Glu Val Phe Gly Thr Ala Arg Arg Ile Thr Val Ser Lys 310 315 320 325 gac gaa acc atc atc gtt gat ggt gca ggt tcc gca gaa gac gtt gaa 1123 Asp Glu Thr Ile Ile Val Asp Gly Ala Gly Ser Ala Glu Asp Val Glu 330 335 340 gca cgt cgc ggc cag atc cgt cgc gaa atc gcc aac acc gat tcc acc 1171 Ala Arg Arg Gly Gln Ile Arg Arg Glu Ile Ala Asn Thr Asp Ser Thr 345 350 355 tgg gat cgc gaa aag gca gaa gag cgt ttg gct aag ctc tcc ggt ggt 1219 Trp Asp Arg Glu Lys Ala Glu Glu Arg Leu Ala Lys Leu Ser Gly Gly 360 365 370 att gct gtc atc cgc gtt ggt gca gca act gaa acc gaa gtc aac gac 1267 Ile Ala Val Ile Arg Val Gly Ala Ala Thr Glu Thr Glu Val Asn Asp 375 380 385 cgc aag ctg cgt gtc gaa gat gcc atc aac gct gct cgc gca gca gca 1315 Arg Lys Leu Arg Val Glu Asp Ala Ile Asn Ala Ala Arg Ala Ala Ala 390 395 400 405 caa gaa ggc gtt atc gct ggt ggc ggt tcc gct ttg gtt cag atc gct 1363 Gln Glu Gly Val Ile Ala Gly Gly Gly Ser Ala Leu Val Gln Ile Ala 410 415 420 gag act ctg aag gct tac gcc gaa gag ttc gaa ggc gac cag aag gtc 1411 Glu Thr Leu Lys Ala Tyr Ala Glu Glu Phe Glu Gly Asp Gln Lys Val 425 430 435 ggc gtt cgc gca ctg gct act gct ttg ggc aag cca gcg tac tgg atc 1459 Gly Val Arg Ala Leu Ala Thr Ala Leu Gly Lys Pro Ala Tyr Trp Ile 440 445 450 gcc tcc aac gca ggt ctt gac ggc tct gtt gtt gtt gca cgc act gct 1507 Ala Ser Asn Ala Gly Leu Asp Gly Ser Val Val Val Ala Arg Thr Ala 455 460 465 gct ctg cca aac ggc gag ggc ttc aac gct gca act ttg gaa tac gga 1555 Ala Leu Pro Asn Gly Glu Gly Phe Asn Ala Ala Thr Leu Glu Tyr Gly 470 475 480 485 aac ctg atc aac gac ggt gtc atc gac cca gtc aag gtc acc cat tcc 1603 Asn Leu Ile Asn Asp Gly Val Ile Asp Pro Val Lys Val Thr His Ser 490 495 500 gca gta gtg aat gca acc tct gtt gca cgc atg gtt ctg acc act gag 1651 Ala Val Val Asn Ala Thr Ser Val Ala Arg Met Val Leu Thr Thr Glu 505 510 515 gct tct gtt gtt gag aag cct gca gaa gaa gca gcc gat gca cat gca 1699 Ala Ser Val Val Glu Lys Pro Ala Glu Glu Ala Ala Asp Ala His Ala 520 525 530 gga cat cat cac cac taaagttctg tgaaaaacac cgtggggcag 1744 Gly His His His His 535 <210> 56 <211> 538 <212> PRT <213> Corynebacterium glutamicum <400> 56 Met Ala Lys Leu Ile Ala Phe Asp Gln Asp Ala Arg Glu Gly Ile Leu 1 5 10 15 Arg Gly Val Asp Ala Leu Ala Asn Ala Val Lys Val Thr Leu Gly Pro 20 25 30 Arg Gly Arg Asn Val Val Leu Asp Lys Ala Phe Gly Gly Pro Leu Val 35 40 45 Thr Asn Asp Gly Val Thr Ile Ala Arg Asp Ile Asp Leu Glu Asp Pro 50 55 60 Phe Glu Asn Leu Gly Ala Gln Leu Val Lys Ser Val Ala Val Lys Thr 65 70 75 80 Asn Asp Ile Ala Gly Asp Gly Thr Thr Thr Ala Thr Leu Leu Ala Gln 85 90 95 Ala Leu Ile Ala Glu Gly Leu Arg Asn Val Ala Ala Gly Ala Asn Pro 100 105 110 Met Glu Leu Asn Lys Gly Ile Ser Ala Ala Ala Glu Lys Thr Leu Glu 115 120 125 Glu Leu Lys Ala Arg Ala Thr Glu Val Ser Asp Thr Lys Glu Ile Ala 130 135 140 Asn Val Ala Thr Val Ser Ser Arg Asp Glu Val Val Gly Glu Ile Val 145 150 155 160 Ala Ala Ala Met Glu Lys Val Gly Lys Asp Gly Val Val Thr Val Glu 165 170 175 Glu Ser Gln Ser Ile Glu Thr Ala Leu Glu Val Thr Glu Gly Ile Ser 180 185 190 Phe Asp Lys Gly Tyr Leu Ser Pro Tyr Phe Ile Asn Asp Asn Asp Thr 195 200 205 Gln Gln Ala Val Leu Asp Asn Pro Ala Val Leu Leu Val Arg Asn Lys 210 215 220 Ile Ser Ser Leu Pro Asp Phe Leu Pro Leu Leu Glu Lys Val Val Glu 225 230 235 240 Ser Asn Arg Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly Glu Pro 245 250 255 Leu Gln Thr Leu Val Val Asn Ser Ile Arg Lys Thr Ile Lys Val Val 260 265 270 Ala Val Lys Ser Pro Tyr Phe Gly Asp Arg Arg Lys Ala Phe Met Asp 275 280 285 Asp Leu Ala Ile Val Thr Lys Ala Thr Val Val Asp Pro Glu Val Gly 290 295 300 Ile Asn Leu Asn Glu Ala Gly Glu Glu Val Phe Gly Thr Ala Arg Arg 305 310 315 320 Ile Thr Val Ser Lys Asp Glu Thr Ile Ile Val Asp Gly Ala Gly Ser 325 330 335 Ala Glu Asp Val Glu Ala Arg Arg Gly Gln Ile Arg Arg Glu Ile Ala 340 345 350 Asn Thr Asp Ser Thr Trp Asp Arg Glu Lys Ala Glu Glu Arg Leu Ala 355 360 365 Lys Leu Ser Gly Gly Ile Ala Val Ile Arg Val Gly Ala Ala Thr Glu 370 375 380 Thr Glu Val Asn Asp Arg Lys Leu Arg Val Glu Asp Ala Ile Asn Ala 385 390 395 400 Ala Arg Ala Ala Ala Gln Glu Gly Val Ile Ala Gly Gly Gly Ser Ala 405 410 415 Leu Val Gln Ile Ala Glu Thr Leu Lys Ala Tyr Ala Glu Glu Phe Glu 420 425 430 Gly Asp Gln Lys Val Gly Val Arg Ala Leu Ala Thr Ala Leu Gly Lys 435 440 445 Pro Ala Tyr Trp Ile Ala Ser Asn Ala Gly Leu Asp Gly Ser Val Val 450 455 460 Val Ala Arg Thr Ala Ala Leu Pro Asn Gly Glu Gly Phe Asn Ala Ala 465 470 475 480 Thr Leu Glu Tyr Gly Asn Leu Ile Asn Asp Gly Val Ile Asp Pro Val 485 490 495 Lys Val Thr His Ser Ala Val Val Asn Ala Thr Ser Val Ala Arg Met 500 505 510 Val Leu Thr Thr Glu Ala Ser Val Val Glu Lys Pro Ala Glu Glu Ala 515 520 525 Ala Asp Ala His Ala Gly His His His His 530 535 <210> 57 <211> 1156 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1126) <223> RXA00496 <400> 57 ctgcagagat ggtgggcagc accccaggtg ctgtacgagt tgcccaacac agggcactca 60 cgacacttcg aagcacactt gagcagcagg agaacaagta atg act cga cgt cta 115 Met Thr Arg Arg Leu 1 5 cat ggt ggt gag cag gat ggc cag gaa cac gtt aaa gga cag cta aag 163 His Gly Gly Glu Gln Asp Gly Gln Glu His Val Lys Gly Gln Leu Lys 10 15 20 cag ctg ttc gac gac gac gcg ttc ttg act gac ctg tcc cgc ggc gtt 211 Gln Leu Phe Asp Asp Asp Ala Phe Leu Thr Asp Leu Ser Arg Gly Val 25 30 35 gat ccc tca gag ggc gat gac gcc ctc gct ggc ctc ctc ctc gat tta 259 Asp Pro Ser Glu Gly Asp Asp Ala Leu Ala Gly Leu Leu Leu Asp Leu 40 45 50 aca aag gaa gct cag gag ccg ccg gca aca atg ccg gat tgg tct act 307 Thr Lys Glu Ala Gln Glu Pro Pro Ala Thr Met Pro Asp Trp Ser Thr 55 60 65 ttg ctc cct gga att ttg gat cag gat cag gat ttg cca gtg gaa tcc 355 Leu Leu Pro Gly Ile Leu Asp Gln Asp Gln Asp Leu Pro Val Glu Ser 70 75 80 85 act tcg gac acc acg gtt atg cag gca tca aac cct gca acc caa gaa 403 Thr Ser Asp Thr Thr Val Met Gln Ala Ser Asn Pro Ala Thr Gln Glu 90 95 100 ttc gca cct gtt tct att tct gat acc ccc aac act gca act aat tca 451 Phe Ala Pro Val Ser Ile Ser Asp Thr Pro Asn Thr Ala Thr Asn Ser 105 110 115 gct gat gca gat gag tcc gca act gtt gtt cca ctt gca gca cgc cgt 499 Ala Asp Ala Asp Glu Ser Ala Thr Val Val Pro Leu Ala Ala Arg Arg 120 125 130 gag aag cgt gcc aag agc gga tca agc ggg gtt cat tca ctg gat gct 547 Glu Lys Arg Ala Lys Ser Gly Ser Ser Gly Val His Ser Leu Asp Ala 135 140 145 tcg gca acc cag cgc aaa tct cac cca ttc ctt agc ggt ttg gtg ggt 595 Ser Ala Thr Gln Arg Lys Ser His Pro Phe Leu Ser Gly Leu Val Gly 150 155 160 165 gct gca gct gca act cta gtc atc gca ggc ggt gga gca gca gtg tac 643 Ala Ala Ala Ala Thr Leu Val Ile Ala Gly Gly Gly Ala Ala Val Tyr 170 175 180 aac gct gat gaa aac tcc ccg ttg tat ggc atg aat cag cag ctg ttt 691 Asn Ala Asp Glu Asn Ser Pro Leu Tyr Gly Met Asn Gln Gln Leu Phe 185 190 195 ggc aat caa gat tct cca agc gtg gtg gag ctt gcc tcc acg ctg gaa 739 Gly Asn Gln Asp Ser Pro Ser Val Val Glu Leu Ala Ser Thr Leu Glu 200 205 210 gaa gtt gat agt cgt aca gct agt ggc gat gtg gaa ggg gca cgt gct 787 Glu Val Asp Ser Arg Thr Ala Ser Gly Asp Val Glu Gly Ala Arg Ala 215 220 225 cta ctc gag cag gct cga gca atg ctg gat ggc atg gca cct cct cga 835 Leu Leu Glu Gln Ala Arg Ala Met Leu Asp Gly Met Ala Pro Pro Arg 230 235 240 245 aag gcg ccg tcg gag gca acc cga acg gtt gaa tct gaa cca ggt act 883 Lys Ala Pro Ser Glu Ala Thr Arg Thr Val Glu Ser Glu Pro Gly Thr 250 255 260 cag acg ttg act gca acg gtt act gaa tcc gca agt ccg gaa cca ccg 931 Gln Thr Leu Thr Ala Thr Val Thr Glu Ser Ala Ser Pro Glu Pro Pro 265 270 275 gtc acg gaa act caa act gtt acc tcc acc gag gta cag aca gtg aca 979 Val Thr Glu Thr Gln Thr Val Thr Ser Thr Glu Val Gln Thr Val Thr 280 285 290 acc act gcg gtt gct cca ccg gtc tgg act cct aat cca gag cca aca 1027 Thr Thr Ala Val Ala Pro Pro Val Trp Thr Pro Asn Pro Glu Pro Thr 295 300 305 acc aca gct gcc ccg act tct acg cct tca act ggt ggc ggt gag gga 1075 Thr Thr Ala Ala Pro Thr Ser Thr Pro Ser Thr Gly Gly Gly Glu Gly 310 315 320 325 acc ggc aat gat ggt gac tct gga ctt gtg cca cct cag act cct gga 1123 Thr Gly Asn Asp Gly Asp Ser Gly Leu Val Pro Pro Gln Thr Pro Gly 330 335 340 aac taggtaaaaa tataaaaact gctagcaacg 1156 Asn <210> 58 <211> 342 <212> PRT <213> Corynebacterium glutamicum <400> 58 Met Thr Arg Arg Leu His Gly Gly Glu Gln Asp Gly Gln Glu His Val 1 5 10 15 Lys Gly Gln Leu Lys Gln Leu Phe Asp Asp Asp Ala Phe Leu Thr Asp 20 25 30 Leu Ser Arg Gly Val Asp Pro Ser Glu Gly Asp Asp Ala Leu Ala Gly 35 40 45 Leu Leu Leu Asp Leu Thr Lys Glu Ala Gln Glu Pro Pro Ala Thr Met 50 55 60 Pro Asp Trp Ser Thr Leu Leu Pro Gly Ile Leu Asp Gln Asp Gln Asp 65 70 75 80 Leu Pro Val Glu Ser Thr Ser Asp Thr Thr Val Met Gln Ala Ser Asn 85 90 95 Pro Ala Thr Gln Glu Phe Ala Pro Val Ser Ile Ser Asp Thr Pro Asn 100 105 110 Thr Ala Thr Asn Ser Ala Asp Ala Asp Glu Ser Ala Thr Val Val Pro 115 120 125 Leu Ala Ala Arg Arg Glu Lys Arg Ala Lys Ser Gly Ser Ser Gly Val 130 135 140 His Ser Leu Asp Ala Ser Ala Thr Gln Arg Lys Ser His Pro Phe Leu 145 150 155 160 Ser Gly Leu Val Gly Ala Ala Ala Ala Thr Leu Val Ile Ala Gly Gly 165 170 175 Gly Ala Ala Val Tyr Asn Ala Asp Glu Asn Ser Pro Leu Tyr Gly Met 180 185 190 Asn Gln Gln Leu Phe Gly Asn Gln Asp Ser Pro Ser Val Val Glu Leu 195 200 205 Ala Ser Thr Leu Glu Glu Val Asp Ser Arg Thr Ala Ser Gly Asp Val 210 215 220 Glu Gly Ala Arg Ala Leu Leu Glu Gln Ala Arg Ala Met Leu Asp Gly 225 230 235 240 Met Ala Pro Pro Arg Lys Ala Pro Ser Glu Ala Thr Arg Thr Val Glu 245 250 255 Ser Glu Pro Gly Thr Gln Thr Leu Thr Ala Thr Val Thr Glu Ser Ala 260 265 270 Ser Pro Glu Pro Pro Val Thr Glu Thr Gln Thr Val Thr Ser Thr Glu 275 280 285 Val Gln Thr Val Thr Thr Thr Ala Val Ala Pro Pro Val Trp Thr Pro 290 295 300 Asn Pro Glu Pro Thr Thr Thr Ala Ala Pro Thr Ser Thr Pro Ser Thr 305 310 315 320 Gly Gly Gly Glu Gly Thr Gly Asn Asp Gly Asp Ser Gly Leu Val Pro 325 330 335 Pro Gln Thr Pro Gly Asn 340 <210> 59 <211> 1852 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1822) <223> RXA00503 <400> 59 aatccacgaa ggtgcccaag aatcaccaat ttcggtcgga actgatcctt ctttgtccgt 60 tgagacccca caggtgtttt aaacatttag tattagttcc atg aaa cca gtc ttc 115 Met Lys Pro Val Phe 1 5 tcc gtt gac caa atc cga cgc gca gaa aac acc ctt ttt gag ctt cag 163 Ser Val Asp Gln Ile Arg Arg Ala Glu Asn Thr Leu Phe Glu Leu Gln 10 15 20 gca gat ccg gat gag ctg atg atc tcc gcg gca tcg gcg gtg gcc gat 211 Ala Asp Pro Asp Glu Leu Met Ile Ser Ala Ala Ser Ala Val Ala Asp 25 30 35 gtc gcg ttg gca atg gtg gac ggc ccc gct cca gcg gtc tcc agt gag 259 Val Ala Leu Ala Met Val Asp Gly Pro Ala Pro Ala Val Ser Ser Glu 40 45 50 gag tca atc ctg ctg ctg gtc ggc ccc ggt ggc aac ggt ggc gac gcc 307 Glu Ser Ile Leu Leu Leu Val Gly Pro Gly Gly Asn Gly Gly Asp Ala 55 60 65 ttg tat gca ggc gcg ttc ctt gca gaa gaa ggc cac cac gtt gat gct 355 Leu Tyr Ala Gly Ala Phe Leu Ala Glu Glu Gly His His Val Asp Ala 70 75 80 85 ttg ctg ttg gga aac ggc aaa gtc cat caa tca gca ttg gca tat tat 403 Leu Leu Leu Gly Asn Gly Lys Val His Gln Ser Ala Leu Ala Tyr Tyr 90 95 100 gag tct ttg ggc ggg cag atc att tcc gat ttt ccc cct cac tac ctc 451 Glu Ser Leu Gly Gly Gln Ile Ile Ser Asp Phe Pro Pro His Tyr Leu 105 110 115 tac cgc ctg gtg att gat ggt ttg ttt ggc atc ggt ggt cgg gga ggg 499 Tyr Arg Leu Val Ile Asp Gly Leu Phe Gly Ile Gly Gly Arg Gly Gly 120 125 130 ctc acc cca gag ctg gcc agt ttg gtg gag tct ttt tcc gct tca ggt 547 Leu Thr Pro Glu Leu Ala Ser Leu Val Glu Ser Phe Ser Ala Ser Gly 135 140 145 atc ccc att ttg gcg att gat gtg ccg tct ggc gtg cat gcc gat agt 595 Ile Pro Ile Leu Ala Ile Asp Val Pro Ser Gly Val His Ala Asp Ser 150 155 160 165 ggt gaa ctg ccg ccc ggc gtg atg gtg acg gtg gaa gga ttt gat aat 643 Gly Glu Leu Pro Pro Gly Val Met Val Thr Val Glu Gly Phe Asp Asn 170 175 180 gat gca ccg atg gcg cgt cag aaa att ccg gca cac att gac gct gat 691 Asp Ala Pro Met Ala Arg Gln Lys Ile Pro Ala His Ile Asp Ala Asp 185 190 195 gtc acg atc acg ttt ggc ggt ttg aga cgc gcc cac gcg gtc agt cct 739 Val Thr Ile Thr Phe Gly Gly Leu Arg Arg Ala His Ala Val Ser Pro 200 205 210 gcg tgt ggt gaa gtg ctc tgt gct gat atc aac atc gct ggt ggc ggc 787 Ala Cys Gly Glu Val Leu Cys Ala Asp Ile Asn Ile Ala Gly Gly Gly 215 220 225 gga aaa tcg ctg tcc gct gag ttg agt cag gtg cag gca gaa gac gcg 835 Gly Lys Ser Leu Ser Ala Glu Leu Ser Gln Val Gln Ala Glu Asp Ala 230 235 240 245 acc ccg cag atg ttt gcc tcc aag gcg tat caa cgg aaa gat tcg ctt 883 Thr Pro Gln Met Phe Ala Ser Lys Ala Tyr Gln Arg Lys Asp Ser Leu 250 255 260 ttt gag cgc gcg aat ctc aaa gct acg gcg cca cat atc cat agg atc 931 Phe Glu Arg Ala Asn Leu Lys Ala Thr Ala Pro His Ile His Arg Ile 265 270 275 ggc cag cac ttt acc gtg ttg aac atg gag cct ggc ccg gat cat gat 979 Gly Gln His Phe Thr Val Leu Asn Met Glu Pro Gly Pro Asp His Asp 280 285 290 aaa tac agt ggc gga att gtc ggc att gtt gca ggt agt ggc acc tat 1027 Lys Tyr Ser Gly Gly Ile Val Gly Ile Val Ala Gly Ser Gly Thr Tyr 295 300 305 cca ggt gct gct gtg ctg tcg gtg aag gcg gct gtc agg gcc aca agc 1075 Pro Gly Ala Ala Val Leu Ser Val Lys Ala Ala Val Arg Ala Thr Ser 310 315 320 325 gcc atg gtt cga tac gtt ggc cct gcg tta aat ttt gtc atc cag tcg 1123 Ala Met Val Arg Tyr Val Gly Pro Ala Leu Asn Phe Val Ile Gln Ser 330 335 340 ctg ccg gag gtc gtc gca acg caa tca ctt gcc acc gcc ggc cgc gtg 1171 Leu Pro Glu Val Val Ala Thr Gln Ser Leu Ala Thr Ala Gly Arg Val 345 350 355 caa gcg tgg gtg cac ggc ccc gga cgc ggg ctg gag gct gag caa tca 1219 Gln Ala Trp Val His Gly Pro Gly Arg Gly Leu Glu Ala Glu Gln Ser 360 365 370 gcc gag ctt gcg gag ctt ttg agc cgg cct gag cct gtg ctt atc gac 1267 Ala Glu Leu Ala Glu Leu Leu Ser Arg Pro Glu Pro Val Leu Ile Asp 375 380 385 gcc gac agc ctc tca tta ctc cag ctc tca gcg gag ctt cgg cag gcg 1315 Ala Asp Ser Leu Ser Leu Leu Gln Leu Ser Ala Glu Leu Arg Gln Ala 390 395 400 405 ttg cgc gag cga aaa gca cca acg gtg ctc act ccg cac aag ggc gaa 1363 Leu Arg Glu Arg Lys Ala Pro Thr Val Leu Thr Pro His Lys Gly Glu 410 415 420 ttt gaa cgc atc gca gca gaa tta cgc tct gaa ggc gtc gag att ccc 1411 Phe Glu Arg Ile Ala Ala Glu Leu Arg Ser Glu Gly Val Glu Ile Pro 425 430 435 caa gcg gac aaa gat ccc att ggt gct gcg caa gcg tta gct aaa gaa 1459 Gln Ala Asp Lys Asp Pro Ile Gly Ala Ala Gln Ala Leu Ala Lys Glu 440 445 450 ttt gat tgt tgc gta ctg ctc aag ggg aaa tac acc gtc att gca gct 1507 Phe Asp Cys Cys Val Leu Leu Lys Gly Lys Tyr Thr Val Ile Ala Ala 455 460 465 cac gac ttt gtg cat gcg atc aac gct ggg cat tcc tgg ttg gct aca 1555 His Asp Phe Val His Ala Ile Asn Ala Gly His Ser Trp Leu Ala Thr 470 475 480 485 cct ggc tct ggc gat gtg ttg tca ggt ctt gtc ggt gca cac ttg gct 1603 Pro Gly Ser Gly Asp Val Leu Ser Gly Leu Val Gly Ala His Leu Ala 490 495 500 caa agc tac gca gaa tta aac cgc ttg ccg gag ttt ttc ccc gat gtg 1651 Gln Ser Tyr Ala Glu Leu Asn Arg Leu Pro Glu Phe Phe Pro Asp Val 505 510 515 acc ttg tct gat tcg gcg att tac acc cag att gca cct gct gcg acc 1699 Thr Leu Ser Asp Ser Ala Ile Tyr Thr Gln Ile Ala Pro Ala Ala Thr 520 525 530 atc cac gcg gtt gct gct ggg ttg gcc gca cga acc gaa ttt ggg ttt 1747 Ile His Ala Val Ala Ala Gly Leu Ala Ala Arg Thr Glu Phe Gly Phe 535 540 545 gcg ccg acc tcc gca agt ttg atc gct gat gcc atc cct gca gcg acc 1795 Ala Pro Thr Ser Ala Ser Leu Ile Ala Asp Ala Ile Pro Ala Ala Thr 550 555 560 565 gcc aag gtg gat ttg aag cga att gtc tagctctgca tgaattccgt 1842 Ala Lys Val Asp Leu Lys Arg Ile Val 570 atgaattctt 1852 <210> 60 <211> 574 <212> PRT <213> Corynebacterium glutamicum <400> 60 Met Lys Pro Val Phe Ser Val Asp Gln Ile Arg Arg Ala Glu Asn Thr 1 5 10 15 Leu Phe Glu Leu Gln Ala Asp Pro Asp Glu Leu Met Ile Ser Ala Ala 20 25 30 Ser Ala Val Ala Asp Val Ala Leu Ala Met Val Asp Gly Pro Ala Pro 35 40 45 Ala Val Ser Ser Glu Glu Ser Ile Leu Leu Leu Val Gly Pro Gly Gly 50 55 60 Asn Gly Gly Asp Ala Leu Tyr Ala Gly Ala Phe Leu Ala Glu Glu Gly 65 70 75 80 His His Val Asp Ala Leu Leu Leu Gly Asn Gly Lys Val His Gln Ser 85 90 95 Ala Leu Ala Tyr Tyr Glu Ser Leu Gly Gly Gln Ile Ile Ser Asp Phe 100 105 110 Pro Pro His Tyr Leu Tyr Arg Leu Val Ile Asp Gly Leu Phe Gly Ile 115 120 125 Gly Gly Arg Gly Gly Leu Thr Pro Glu Leu Ala Ser Leu Val Glu Ser 130 135 140 Phe Ser Ala Ser Gly Ile Pro Ile Leu Ala Ile Asp Val Pro Ser Gly 145 150 155 160 Val His Ala Asp Ser Gly Glu Leu Pro Pro Gly Val Met Val Thr Val 165 170 175 Glu Gly Phe Asp Asn Asp Ala Pro Met Ala Arg Gln Lys Ile Pro Ala 180 185 190 His Ile Asp Ala Asp Val Thr Ile Thr Phe Gly Gly Leu Arg Arg Ala 195 200 205 His Ala Val Ser Pro Ala Cys Gly Glu Val Leu Cys Ala Asp Ile Asn 210 215 220 Ile Ala Gly Gly Gly Gly Lys Ser Leu Ser Ala Glu Leu Ser Gln Val 225 230 235 240 Gln Ala Glu Asp Ala Thr Pro Gln Met Phe Ala Ser Lys Ala Tyr Gln 245 250 255 Arg Lys Asp Ser Leu Phe Glu Arg Ala Asn Leu Lys Ala Thr Ala Pro 260 265 270 His Ile His Arg Ile Gly Gln His Phe Thr Val Leu Asn Met Glu Pro 275 280 285 Gly Pro Asp His Asp Lys Tyr Ser Gly Gly Ile Val Gly Ile Val Ala 290 295 300 Gly Ser Gly Thr Tyr Pro Gly Ala Ala Val Leu Ser Val Lys Ala Ala 305 310 315 320 Val Arg Ala Thr Ser Ala Met Val Arg Tyr Val Gly Pro Ala Leu Asn 325 330 335 Phe Val Ile Gln Ser Leu Pro Glu Val Val Ala Thr Gln Ser Leu Ala 340 345 350 Thr Ala Gly Arg Val Gln Ala Trp Val His Gly Pro Gly Arg Gly Leu 355 360 365 Glu Ala Glu Gln Ser Ala Glu Leu Ala Glu Leu Leu Ser Arg Pro Glu 370 375 380 Pro Val Leu Ile Asp Ala Asp Ser Leu Ser Leu Leu Gln Leu Ser Ala 385 390 395 400 Glu Leu Arg Gln Ala Leu Arg Glu Arg Lys Ala Pro Thr Val Leu Thr 405 410 415 Pro His Lys Gly Glu Phe Glu Arg Ile Ala Ala Glu Leu Arg Ser Glu 420 425 430 Gly Val Glu Ile Pro Gln Ala Asp Lys Asp Pro Ile Gly Ala Ala Gln 435 440 445 Ala Leu Ala Lys Glu Phe Asp Cys Cys Val Leu Leu Lys Gly Lys Tyr 450 455 460 Thr Val Ile Ala Ala His Asp Phe Val His Ala Ile Asn Ala Gly His 465 470 475 480 Ser Trp Leu Ala Thr Pro Gly Ser Gly Asp Val Leu Ser Gly Leu Val 485 490 495 Gly Ala His Leu Ala Gln Ser Tyr Ala Glu Leu Asn Arg Leu Pro Glu 500 505 510 Phe Phe Pro Asp Val Thr Leu Ser Asp Ser Ala Ile Tyr Thr Gln Ile 515 520 525 Ala Pro Ala Ala Thr Ile His Ala Val Ala Ala Gly Leu Ala Ala Arg 530 535 540 Thr Glu Phe Gly Phe Ala Pro Thr Ser Ala Ser Leu Ile Ala Asp Ala 545 550 555 560 Ile Pro Ala Ala Thr Ala Lys Val Asp Leu Lys Arg Ile Val 565 570 <210> 61 <211> 985 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(955) <223> RXA00507 <400> 61 gttcatgttg aactattgtg ccaccaaccg cggacagaaa tacgattggt gccggggtta 60 gtgccagtat tgccccacgc tttcaactat ccttaaacac gtg gct gag aat ctg 115 Val Ala Glu Asn Leu 1 5 aac aaa cac ctg tcc aaa ctg tcc aag cgc gga ccg cac cgc gtg ctg 163 Asn Lys His Leu Ser Lys Leu Ser Lys Arg Gly Pro His Arg Val Leu 10 15 20 gta ggc gat atg aac tac gcc ggc atc ccg ggc aaa atc tac acc cca 211 Val Gly Asp Met Asn Tyr Ala Gly Ile Pro Gly Lys Ile Tyr Thr Pro 25 30 35 gca gaa ggc gac ggc atc cca ggt gta gct ttc ggc cac gac tgg atg 259 Ala Glu Gly Asp Gly Ile Pro Gly Val Ala Phe Gly His Asp Trp Met 40 45 50 aaa tcc atc aag tac tac cac caa act ttg cga cac ctc gcg tcc tgg 307 Lys Ser Ile Lys Tyr Tyr His Gln Thr Leu Arg His Leu Ala Ser Trp 55 60 65 ggc atc gct gtt gcc gcc cca gac acc gaa aat ggc ttc atg cca gac 355 Gly Ile Ala Val Ala Ala Pro Asp Thr Glu Asn Gly Phe Met Pro Asp 70 75 80 85 cac aaa ggt ttc gcc tct gac ctc gaa tcc tcc att cag att ctc ggc 403 His Lys Gly Phe Ala Ser Asp Leu Glu Ser Ser Ile Gln Ile Leu Gly 90 95 100 ggc gta aaa ctc ggc tcc gga aac gtc acc gtc aac cca gcc tgc ctc 451 Gly Val Lys Leu Gly Ser Gly Asn Val Thr Val Asn Pro Ala Cys Leu 105 110 115 ggt gta gta ggc cac ggc atg ggt gct ggg gct gca gta cta tcc gca 499 Gly Val Val Gly His Gly Met Gly Ala Gly Ala Ala Val Leu Ser Ala 120 125 130 gca aac cgc gac ctc gtg cgc gca gtc gga gca atc tac cca gcg aaa 547 Ala Asn Arg Asp Leu Val Arg Ala Val Gly Ala Ile Tyr Pro Ala Lys 135 140 145 acc tcc ccc tca gca atc gac gcc gcc ttc gct gtc aaa gcc cca ggc 595 Thr Ser Pro Ser Ala Ile Asp Ala Ala Phe Ala Val Lys Ala Pro Gly 150 155 160 165 cta gtc atc gga tcc tcc agc ctc ggc ctc ttt gaa tcc ggc gag cca 643 Leu Val Ile Gly Ser Ser Ser Leu Gly Leu Phe Glu Ser Gly Glu Pro 170 175 180 gca aaa ctc gca gcc aac tgg gcc ggc gat gtc tgc tac cgc gaa tca 691 Ala Lys Leu Ala Ala Asn Trp Ala Gly Asp Val Cys Tyr Arg Glu Ser 185 190 195 gaa aaa ggc aac caa cag ggc ttc tct gaa gac acc atg ttc aaa ctt 739 Glu Lys Gly Asn Gln Gln Gly Phe Ser Glu Asp Thr Met Phe Lys Leu 200 205 210 gtc gca gga atc ggc agc cca caa acc gga gct caa gaa acc gtc cgc 787 Val Ala Gly Ile Gly Ser Pro Gln Thr Gly Ala Gln Glu Thr Val Arg 215 220 225 ggc ctc ctc acc gga ttc ctt ctc cac caa ctt gcc gga gaa aag aaa 835 Gly Leu Leu Thr Gly Phe Leu Leu His Gln Leu Ala Gly Glu Lys Lys 230 235 240 245 tac aaa gca ttc tcc gaa cca gac gct gaa gct aag aaa gtt gtc tcc 883 Tyr Lys Ala Phe Ser Glu Pro Asp Ala Glu Ala Lys Lys Val Val Ser 250 255 260 tac ttc ggc cag gag ctg cag gaa cat gcc ttc cct aag gac acg tcc 931 Tyr Phe Gly Gln Glu Leu Gln Glu His Ala Phe Pro Lys Asp Thr Ser 265 270 275 cca ttc gcg ttc ctt aac gag aag tagttcgctt ttcttagtgg gtgattttgt 985 Pro Phe Ala Phe Leu Asn Glu Lys 280 285 <210> 62 <211> 285 <212> PRT <213> Corynebacterium glutamicum <400> 62 Val Ala Glu Asn Leu Asn Lys His Leu Ser Lys Leu Ser Lys Arg Gly 1 5 10 15 Pro His Arg Val Leu Val Gly Asp Met Asn Tyr Ala Gly Ile Pro Gly 20 25 30 Lys Ile Tyr Thr Pro Ala Glu Gly Asp Gly Ile Pro Gly Val Ala Phe 35 40 45 Gly His Asp Trp Met Lys Ser Ile Lys Tyr Tyr His Gln Thr Leu Arg 50 55 60 His Leu Ala Ser Trp Gly Ile Ala Val Ala Ala Pro Asp Thr Glu Asn 65 70 75 80 Gly Phe Met Pro Asp His Lys Gly Phe Ala Ser Asp Leu Glu Ser Ser 85 90 95 Ile Gln Ile Leu Gly Gly Val Lys Leu Gly Ser Gly Asn Val Thr Val 100 105 110 Asn Pro Ala Cys Leu Gly Val Val Gly His Gly Met Gly Ala Gly Ala 115 120 125 Ala Val Leu Ser Ala Ala Asn Arg Asp Leu Val Arg Ala Val Gly Ala 130 135 140 Ile Tyr Pro Ala Lys Thr Ser Pro Ser Ala Ile Asp Ala Ala Phe Ala 145 150 155 160 Val Lys Ala Pro Gly Leu Val Ile Gly Ser Ser Ser Leu Gly Leu Phe 165 170 175 Glu Ser Gly Glu Pro Ala Lys Leu Ala Ala Asn Trp Ala Gly Asp Val 180 185 190 Cys Tyr Arg Glu Ser Glu Lys Gly Asn Gln Gln Gly Phe Ser Glu Asp 195 200 205 Thr Met Phe Lys Leu Val Ala Gly Ile Gly Ser Pro Gln Thr Gly Ala 210 215 220 Gln Glu Thr Val Arg Gly Leu Leu Thr Gly Phe Leu Leu His Gln Leu 225 230 235 240 Ala Gly Glu Lys Lys Tyr Lys Ala Phe Ser Glu Pro Asp Ala Glu Ala 245 250 255 Lys Lys Val Val Ser Tyr Phe Gly Gln Glu Leu Gln Glu His Ala Phe 260 265 270 Pro Lys Asp Thr Ser Pro Phe Ala Phe Leu Asn Glu Lys 275 280 285 <210> 63 <211> 1639 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1609) <223> RXA00510 <400> 63 acgcttttac ccaaacaacc caagccgccg aggaagaagt taaacgattc gacaataccg 60 acaaagtttt tggtgccgga tttgatggga ttgatccgaa gtg aat gat cct tta 115 Val Asn Asp Pro Leu 1 5 gcc ggc tac gga gca gtg atc tcc gca cta caa ggc gcc agt ggt ggg 163 Ala Gly Tyr Gly Ala Val Ile Ser Ala Leu Gln Gly Ala Ser Gly Gly 10 15 20 atg tat cgc gga ccg gcg aaa tcc gaa ggc cag ttg cgc gag atg tac 211 Met Tyr Arg Gly Pro Ala Lys Ser Glu Gly Gln Leu Arg Glu Met Tyr 25 30 35 caa acc atc gaa ggg cta gac acc agc tcg ttg cgc gaa gct gcc gaa 259 Gln Thr Ile Glu Gly Leu Asp Thr Ser Ser Leu Arg Glu Ala Ala Glu 40 45 50 gca gca gtg ggc gga acg aac gaa gcc aga ata caa ggg tgg gtc ggc 307 Ala Ala Val Gly Gly Thr Asn Glu Ala Arg Ile Gln Gly Trp Val Gly 55 60 65 ccg ctc ttg aaa ttc ttc ggg acg gtt ggc ggg gga atg atc gcc acg 355 Pro Leu Leu Lys Phe Phe Gly Thr Val Gly Gly Gly Met Ile Ala Thr 70 75 80 85 gag ata gct gaa cgg gca gtc gat tgg ttc aaa aac cgt aat gat gtg 403 Glu Ile Ala Glu Arg Ala Val Asp Trp Phe Lys Asn Arg Asn Asp Val 90 95 100 gaa gaa gtc agc gaa gcc gct gat aaa gcc gcc gat gcg atc gac tcc 451 Glu Glu Val Ser Glu Ala Ala Asp Lys Ala Ala Asp Ala Ile Asp Ser 105 110 115 act gtc aca gag tcc gac cag ggc atg atg cac att atc cag cag ctc 499 Thr Val Thr Glu Ser Asp Gln Gly Met Met His Ile Ile Gln Gln Leu 120 125 130 ttg gac att gtg tct acg ttg acg cag att ctt ggc agc atg gat cgg 547 Leu Asp Ile Val Ser Thr Leu Thr Gln Ile Leu Gly Ser Met Asp Arg 135 140 145 ggg aaa ttt cct caa gaa ttc cgg gac tgt gtc caa act gga gct gat 595 Gly Lys Phe Pro Gln Glu Phe Arg Asp Cys Val Gln Thr Gly Ala Asp 150 155 160 165 ctt att gac cag gca ggg gac atg ctt gaa gga ttg tgc gct gat cga 643 Leu Ile Asp Gln Ala Gly Asp Met Leu Glu Gly Leu Cys Ala Asp Arg 170 175 180 gat gat gcg att tca cag tgt ttc tcc gcg ttg acc gat cat gga aaa 691 Asp Asp Ala Ile Ser Gln Cys Phe Ser Ala Leu Thr Asp His Gly Lys 185 190 195 caa gtt tgt gaa act gag cca aag ccg ttg tgt agt gca gct tct ggg 739 Gln Val Cys Glu Thr Glu Pro Lys Pro Leu Cys Ser Ala Ala Ser Gly 200 205 210 ggt tca tct ggt gga gcg act tct tcg gct gcg gcc tct tca ggt ggt 787 Gly Ser Ser Gly Gly Ala Thr Ser Ser Ala Ala Ala Ser Ser Gly Gly 215 220 225 tca agc tcg agc act gct agc tct ggg agt tct ggc gga tcg agc agt 835 Ser Ser Ser Ser Thr Ala Ser Ser Gly Ser Ser Gly Gly Ser Ser Ser 230 235 240 245 gct gcg gat agt tcg acg tcg acc aat gct gaa tcc agt gtt gaa aag 883 Ala Ala Asp Ser Ser Thr Ser Thr Asn Ala Glu Ser Ser Val Glu Lys 250 255 260 gaa aag acc aca cct gct gcc gtt gag aaa cct gac gag aaa cca gtg 931 Glu Lys Thr Thr Pro Ala Ala Val Glu Lys Pro Asp Glu Lys Pro Val 265 270 275 gag aag ccg gtt gaa aag acg cca gaa aag ccg gta gaa aaa cct gtc 979 Glu Lys Pro Val Glu Lys Thr Pro Glu Lys Pro Val Glu Lys Pro Val 280 285 290 gag aag caa gag tgt gaa gaa aag cct gac cct gac ccg gaa aaa tgc 1027 Glu Lys Gln Glu Cys Glu Glu Lys Pro Asp Pro Asp Pro Glu Lys Cys 295 300 305 aaa aca gag ccg gtc gag tgt gag cca aca ccg aaa cct gaa aca gag 1075 Lys Thr Glu Pro Val Glu Cys Glu Pro Thr Pro Lys Pro Glu Thr Glu 310 315 320 325 cct gaa cca aaa ccg aca ccc acg ccc aca ccc gga aca cca aca cca 1123 Pro Glu Pro Lys Pro Thr Pro Thr Pro Thr Pro Gly Thr Pro Thr Pro 330 335 340 ata cct gag cta gag act gag gat tgt gaa cct ggc aag gag acg ggc 1171 Ile Pro Glu Leu Glu Thr Glu Asp Cys Glu Pro Gly Lys Glu Thr Gly 345 350 355 aca gac tca gaa tct gaa tcg gaa gag tgc gcc ccc gag ctc aat gac 1219 Thr Asp Ser Glu Ser Glu Ser Glu Glu Cys Ala Pro Glu Leu Asn Asp 360 365 370 gtt cca gaa gag tcg gat ctg att ggg caa ctc atc aag gga gca atc 1267 Val Pro Glu Glu Ser Asp Leu Ile Gly Gln Leu Ile Lys Gly Ala Ile 375 380 385 ggt att ggg att gtt gtt gta ggc gtt ggg ctg ttg gtg aat ttc ctg 1315 Gly Ile Gly Ile Val Val Val Gly Val Gly Leu Leu Val Asn Phe Leu 390 395 400 405 gag cag tgc gtc cct gtg att gaa gaa gta cct gtg ccg gag ccc gag 1363 Glu Gln Cys Val Pro Val Ile Glu Glu Val Pro Val Pro Glu Pro Glu 410 415 420 cct ata cct gaa ccc gct ccg cag cct gag cca act tca gtg aaa cca 1411 Pro Ile Pro Glu Pro Ala Pro Gln Pro Glu Pro Thr Ser Val Lys Pro 425 430 435 cca gag tct gaa cta gat aag gtg gct gag cct gcg ccg aag cca att 1459 Pro Glu Ser Glu Leu Asp Lys Val Ala Glu Pro Ala Pro Lys Pro Ile 440 445 450 cca caa gct aat tac act gct gct gca gca act aac tat tcc gct ccc 1507 Pro Gln Ala Asn Tyr Thr Ala Ala Ala Ala Thr Asn Tyr Ser Ala Pro 455 460 465 gcg cac gct ccc gtt gtc cca att acg ccg gca gca cct gaa gtt ccg 1555 Ala His Ala Pro Val Val Pro Ile Thr Pro Ala Ala Pro Glu Val Pro 470 475 480 485 gca gca cca gaa gtg cct gca ccg gcg gtt aat ctt cac aag gcc ggc 1603 Ala Ala Pro Glu Val Pro Ala Pro Ala Val Asn Leu His Lys Ala Gly 490 495 500 ggg tgg tagcggtgga gtatgcggaa tttctccagc 1639 Gly Trp <210> 64 <211> 503 <212> PRT <213> Corynebacterium glutamicum <400> 64 Val Asn Asp Pro Leu Ala Gly Tyr Gly Ala Val Ile Ser Ala Leu Gln 1 5 10 15 Gly Ala Ser Gly Gly Met Tyr Arg Gly Pro Ala Lys Ser Glu Gly Gln 20 25 30 Leu Arg Glu Met Tyr Gln Thr Ile Glu Gly Leu Asp Thr Ser Ser Leu 35 40 45 Arg Glu Ala Ala Glu Ala Ala Val Gly Gly Thr Asn Glu Ala Arg Ile 50 55 60 Gln Gly Trp Val Gly Pro Leu Leu Lys Phe Phe Gly Thr Val Gly Gly 65 70 75 80 Gly Met Ile Ala Thr Glu Ile Ala Glu Arg Ala Val Asp Trp Phe Lys 85 90 95 Asn Arg Asn Asp Val Glu Glu Val Ser Glu Ala Ala Asp Lys Ala Ala 100 105 110 Asp Ala Ile Asp Ser Thr Val Thr Glu Ser Asp Gln Gly Met Met His 115 120 125 Ile Ile Gln Gln Leu Leu Asp Ile Val Ser Thr Leu Thr Gln Ile Leu 130 135 140 Gly Ser Met Asp Arg Gly Lys Phe Pro Gln Glu Phe Arg Asp Cys Val 145 150 155 160 Gln Thr Gly Ala Asp Leu Ile Asp Gln Ala Gly Asp Met Leu Glu Gly 165 170 175 Leu Cys Ala Asp Arg Asp Asp Ala Ile Ser Gln Cys Phe Ser Ala Leu 180 185 190 Thr Asp His Gly Lys Gln Val Cys Glu Thr Glu Pro Lys Pro Leu Cys 195 200 205 Ser Ala Ala Ser Gly Gly Ser Ser Gly Gly Ala Thr Ser Ser Ala Ala 210 215 220 Ala Ser Ser Gly Gly Ser Ser Ser Ser Thr Ala Ser Ser Gly Ser Ser 225 230 235 240 Gly Gly Ser Ser Ser Ala Ala Asp Ser Ser Thr Ser Thr Asn Ala Glu 245 250 255 Ser Ser Val Glu Lys Glu Lys Thr Thr Pro Ala Ala Val Glu Lys Pro 260 265 270 Asp Glu Lys Pro Val Glu Lys Pro Val Glu Lys Thr Pro Glu Lys Pro 275 280 285 Val Glu Lys Pro Val Glu Lys Gln Glu Cys Glu Glu Lys Pro Asp Pro 290 295 300 Asp Pro Glu Lys Cys Lys Thr Glu Pro Val Glu Cys Glu Pro Thr Pro 305 310 315 320 Lys Pro Glu Thr Glu Pro Glu Pro Lys Pro Thr Pro Thr Pro Thr Pro 325 330 335 Gly Thr Pro Thr Pro Ile Pro Glu Leu Glu Thr Glu Asp Cys Glu Pro 340 345 350 Gly Lys Glu Thr Gly Thr Asp Ser Glu Ser Glu Ser Glu Glu Cys Ala 355 360 365 Pro Glu Leu Asn Asp Val Pro Glu Glu Ser Asp Leu Ile Gly Gln Leu 370 375 380 Ile Lys Gly Ala Ile Gly Ile Gly Ile Val Val Val Gly Val Gly Leu 385 390 395 400 Leu Val Asn Phe Leu Glu Gln Cys Val Pro Val Ile Glu Glu Val Pro 405 410 415 Val Pro Glu Pro Glu Pro Ile Pro Glu Pro Ala Pro Gln Pro Glu Pro 420 425 430 Thr Ser Val Lys Pro Pro Glu Ser Glu Leu Asp Lys Val Ala Glu Pro 435 440 445 Ala Pro Lys Pro Ile Pro Gln Ala Asn Tyr Thr Ala Ala Ala Ala Thr 450 455 460 Asn Tyr Ser Ala Pro Ala His Ala Pro Val Val Pro Ile Thr Pro Ala 465 470 475 480 Ala Pro Glu Val Pro Ala Ala Pro Glu Val Pro Ala Pro Ala Val Asn 485 490 495 Leu His Lys Ala Gly Gly Trp 500 <210> 65 <211> 2290 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2260) <223> RXA00550 <400> 65 gccagctgat tctcagattc agatgaatag gcttaggcgc agtattctct acagcacaag 60 cttcagataa gaaccagatc tgattgaacg gaaacaccag ttg acg aat agt aaa 115 Leu Thr Asn Ser Lys 1 5 aat cct cct gcc aaa aag agc agc ggc aaa agg cgc tta aag agc gac 163 Asn Pro Pro Ala Lys Lys Ser Ser Gly Lys Arg Arg Leu Lys Ser Asp 10 15 20 tct aag ggc tac gct gta aga aac acc atc att ggt gcc att gtt gct 211 Ser Lys Gly Tyr Ala Val Arg Asn Thr Ile Ile Gly Ala Ile Val Ala 25 30 35 gtc att ttg att cca gta atg gtc ttc atg ggt gct tac atc atg gtt 259 Val Ile Leu Ile Pro Val Met Val Phe Met Gly Ala Tyr Ile Met Val 40 45 50 gat gtt cca gaa ccg gaa gag ttg gtt tca ccc cag gtt tcg cag att 307 Asp Val Pro Glu Pro Glu Glu Leu Val Ser Pro Gln Val Ser Gln Ile 55 60 65 tac gca tct gac ggt gag act gaa ttg gca cgc atc gtt cct cca gaa 355 Tyr Ala Ser Asp Gly Glu Thr Glu Leu Ala Arg Ile Val Pro Pro Glu 70 75 80 85 ggc aac cgc cag atg gtg acg atc gat cag gtg cct gac act gtg aaa 403 Gly Asn Arg Gln Met Val Thr Ile Asp Gln Val Pro Asp Thr Val Lys 90 95 100 aat gcg gtg gtg gct gcg gaa gac cga gag ttt tac aca aac ccc ggt 451 Asn Ala Val Val Ala Ala Glu Asp Arg Glu Phe Tyr Thr Asn Pro Gly 105 110 115 ttt tcc att act ggc tat gcc cga gca gca ctt ggc gta atc act ggt 499 Phe Ser Ile Thr Gly Tyr Ala Arg Ala Ala Leu Gly Val Ile Thr Gly 120 125 130 gat tct tca gcg ggt ggt ggt tcc acc att act cag cag tat gtg aag 547 Asp Ser Ser Ala Gly Gly Gly Ser Thr Ile Thr Gln Gln Tyr Val Lys 135 140 145 aag gct gtg gtt ggt gat gag cgt tcg ctg atc cgt aag gct aag gaa 595 Lys Ala Val Val Gly Asp Glu Arg Ser Leu Ile Arg Lys Ala Lys Glu 150 155 160 165 ttg gtc tat tcc gcg aag atg gcc aat gag tgg tct aag gac gag gtc 643 Leu Val Tyr Ser Ala Lys Met Ala Asn Glu Trp Ser Lys Asp Glu Val 170 175 180 ctt gag gct tat ctc aac act gtg tac ttc ggt cga aat gcc tat ggt 691 Leu Glu Ala Tyr Leu Asn Thr Val Tyr Phe Gly Arg Asn Ala Tyr Gly 185 190 195 gtg cag gct gca gct cat gca ttc ttt gat aag cca gta gaa gag ctc 739 Val Gln Ala Ala Ala His Ala Phe Phe Asp Lys Pro Val Glu Glu Leu 200 205 210 acg gct gct gag ggc gca gtg ctg gcg gcc agt att cag ctg cca agc 787 Thr Ala Ala Glu Gly Ala Val Leu Ala Ala Ser Ile Gln Leu Pro Ser 215 220 225 cag ttg gat cct tgg aca aat cca gtt gag gcg gaa acg cgt tgg aac 835 Gln Leu Asp Pro Trp Thr Asn Pro Val Glu Ala Glu Thr Arg Trp Asn 230 235 240 245 tat gtc atg gac ggc ctg gtg gaa att ggc gct atc tcg gca gag gag 883 Tyr Val Met Asp Gly Leu Val Glu Ile Gly Ala Ile Ser Ala Glu Glu 250 255 260 cgc gca gtt gct acc tac cct gaa acc act gac cct gcg tcc aac agt 931 Arg Ala Val Ala Thr Tyr Pro Glu Thr Thr Asp Pro Ala Ser Asn Ser 265 270 275 gcg tac acc gaa gcc acc ggc act aat ggt ttg att aag aac caa gtg 979 Ala Tyr Thr Glu Ala Thr Gly Thr Asn Gly Leu Ile Lys Asn Gln Val 280 285 290 atg gcg gag ttg tct gag ctt ggt atc act gag gat gat gtg caa acc 1027 Met Ala Glu Leu Ser Glu Leu Gly Ile Thr Glu Asp Asp Val Gln Thr 295 300 305 cgt ggt ttg cag gtc acc acc acc att gat cca aag act cag gaa ggt 1075 Arg Gly Leu Gln Val Thr Thr Thr Ile Asp Pro Lys Thr Gln Glu Gly 310 315 320 325 gcc gtt gaa gcg gta caa aac cag ttg gat ctt ctg tct gag aac aac 1123 Ala Val Glu Ala Val Gln Asn Gln Leu Asp Leu Leu Ser Glu Asn Asn 330 335 340 cgt gca gcg gta gtc tcc att gat cct tct aat ggt gcg gtt cgt gct 1171 Arg Ala Ala Val Val Ser Ile Asp Pro Ser Asn Gly Ala Val Arg Ala 345 350 355 tat tac ggc ggc gag gat gcg act ggt tgg gac ttt gca aac gct ccg 1219 Tyr Tyr Gly Gly Glu Asp Ala Thr Gly Trp Asp Phe Ala Asn Ala Pro 360 365 370 ctt cag acc ggt tct aca ttc aag atc ttt ggt ctg gca gca gca ctt 1267 Leu Gln Thr Gly Ser Thr Phe Lys Ile Phe Gly Leu Ala Ala Ala Leu 375 380 385 cag caa ggt att cca ctg tct cag cca tac agc tct gcg ccg gtg act 1315 Gln Gln Gly Ile Pro Leu Ser Gln Pro Tyr Ser Ser Ala Pro Val Thr 390 395 400 405 gtg ggt gat gct caa atc gga aac gtc ggt ggc agc ggt tgt ggt tcc 1363 Val Gly Asp Ala Gln Ile Gly Asn Val Gly Gly Ser Gly Cys Gly Ser 410 415 420 tgt tcc atc gag cag gcg ttg ttg cat tct tac aac acc agc ttc att 1411 Cys Ser Ile Glu Gln Ala Leu Leu His Ser Tyr Asn Thr Ser Phe Ile 425 430 435 cgt ttg cag cag gat ctg gaa aat ggt tca cag gat act gcg gac atg 1459 Arg Leu Gln Gln Asp Leu Glu Asn Gly Ser Gln Asp Thr Ala Asp Met 440 445 450 gcg cat gct ttg ggt atc gcg aag tct ttg cca act atc cct gag aca 1507 Ala His Ala Leu Gly Ile Ala Lys Ser Leu Pro Thr Ile Pro Glu Thr 455 460 465 ctg act gaa aac gga gag acc cct tat gag ggc atc atc ttg ggt cag 1555 Leu Thr Glu Asn Gly Glu Thr Pro Tyr Glu Gly Ile Ile Leu Gly Gln 470 475 480 485 tat gag tcc cgc cca ctt gat atg gct tct gcg atg gca act atc gct 1603 Tyr Glu Ser Arg Pro Leu Asp Met Ala Ser Ala Met Ala Thr Ile Ala 490 495 500 aat gaa ggt gtc tgg cac cgc ccg cac ttc gtg tcc aag gtg gag act 1651 Asn Glu Gly Val Trp His Arg Pro His Phe Val Ser Lys Val Glu Thr 505 510 515 gtc agc ggt gag gtt ctc tac gag ttc gag gat ggc gac ggc gag cgt 1699 Val Ser Gly Glu Val Leu Tyr Glu Phe Glu Asp Gly Asp Gly Glu Arg 520 525 530 cgt gtt tct gaa aag gtt gca ctg aat ctg ctc aag gcc atg ggg cca 1747 Arg Val Ser Glu Lys Val Ala Leu Asn Leu Leu Lys Ala Met Gly Pro 535 540 545 atc gct gca tac tcc aac gga aac gct ctg gct gat ggc cag gtt tct 1795 Ile Ala Ala Tyr Ser Asn Gly Asn Ala Leu Ala Asp Gly Gln Val Ser 550 555 560 565 gca tcc aag act ggt acc act cag ctt ggt gat acc ggt gca aac aag 1843 Ala Ser Lys Thr Gly Thr Thr Gln Leu Gly Asp Thr Gly Ala Asn Lys 570 575 580 gat gcg tgg atg ttg ggt gcg gca cct cag cta gct act gcg gtg tgg 1891 Asp Ala Trp Met Leu Gly Ala Ala Pro Gln Leu Ala Thr Ala Val Trp 585 590 595 gtc gga act gct gat aac act gca ttg tat aac acc tgg ggt ggc agt 1939 Val Gly Thr Ala Asp Asn Thr Ala Leu Tyr Asn Thr Trp Gly Gly Ser 600 605 610 atg tat ggt tct aac tcc cct gcc acg atc tgg aag cag acc atg gat 1987 Met Tyr Gly Ser Asn Ser Pro Ala Thr Ile Trp Lys Gln Thr Met Asp 615 620 625 aac gcc ctc gag aac tcc cct ctc gaa act tgg gat atc gct cca gca 2035 Asn Ala Leu Glu Asn Ser Pro Leu Glu Thr Trp Asp Ile Ala Pro Ala 630 635 640 645 ttg ggg tac ggt aac cca cca gtt ccg gaa tat gtg tgg act cca agt 2083 Leu Gly Tyr Gly Asn Pro Pro Val Pro Glu Tyr Val Trp Thr Pro Ser 650 655 660 cca aac atc gcg act aat gat cca gaa gga gca acc gag gaa gct cca 2131 Pro Asn Ile Ala Thr Asn Asp Pro Glu Gly Ala Thr Glu Glu Ala Pro 665 670 675 gtg gag gat cca aat gca gta atc gat acc cct gct gta gat ccc act 2179 Val Glu Asp Pro Asn Ala Val Ile Asp Thr Pro Ala Val Asp Pro Thr 680 685 690 gca cct gca gag gag acc ggt aac ggt cag gta gaa atc ctg ccg ggg 2227 Ala Pro Ala Glu Glu Thr Gly Asn Gly Gln Val Glu Ile Leu Pro Gly 695 700 705 ctg act atc ccg gga gat ctc tta ggg atc ggc taaaatccgg tcgtagccta 2280 Leu Thr Ile Pro Gly Asp Leu Leu Gly Ile Gly 710 715 720 aacgacctta 2290 <210> 66 <211> 720 <212> PRT <213> Corynebacterium glutamicum <400> 66 Leu Thr Asn Ser Lys Asn Pro Pro Ala Lys Lys Ser Ser Gly Lys Arg 1 5 10 15 Arg Leu Lys Ser Asp Ser Lys Gly Tyr Ala Val Arg Asn Thr Ile Ile 20 25 30 Gly Ala Ile Val Ala Val Ile Leu Ile Pro Val Met Val Phe Met Gly 35 40 45 Ala Tyr Ile Met Val Asp Val Pro Glu Pro Glu Glu Leu Val Ser Pro 50 55 60 Gln Val Ser Gln Ile Tyr Ala Ser Asp Gly Glu Thr Glu Leu Ala Arg 65 70 75 80 Ile Val Pro Pro Glu Gly Asn Arg Gln Met Val Thr Ile Asp Gln Val 85 90 95 Pro Asp Thr Val Lys Asn Ala Val Val Ala Ala Glu Asp Arg Glu Phe 100 105 110 Tyr Thr Asn Pro Gly Phe Ser Ile Thr Gly Tyr Ala Arg Ala Ala Leu 115 120 125 Gly Val Ile Thr Gly Asp Ser Ser Ala Gly Gly Gly Ser Thr Ile Thr 130 135 140 Gln Gln Tyr Val Lys Lys Ala Val Val Gly Asp Glu Arg Ser Leu Ile 145 150 155 160 Arg Lys Ala Lys Glu Leu Val Tyr Ser Ala Lys Met Ala Asn Glu Trp 165 170 175 Ser Lys Asp Glu Val Leu Glu Ala Tyr Leu Asn Thr Val Tyr Phe Gly 180 185 190 Arg Asn Ala Tyr Gly Val Gln Ala Ala Ala His Ala Phe Phe Asp Lys 195 200 205 Pro Val Glu Glu Leu Thr Ala Ala Glu Gly Ala Val Leu Ala Ala Ser 210 215 220 Ile Gln Leu Pro Ser Gln Leu Asp Pro Trp Thr Asn Pro Val Glu Ala 225 230 235 240 Glu Thr Arg Trp Asn Tyr Val Met Asp Gly Leu Val Glu Ile Gly Ala 245 250 255 Ile Ser Ala Glu Glu Arg Ala Val Ala Thr Tyr Pro Glu Thr Thr Asp 260 265 270 Pro Ala Ser Asn Ser Ala Tyr Thr Glu Ala Thr Gly Thr Asn Gly Leu 275 280 285 Ile Lys Asn Gln Val Met Ala Glu Leu Ser Glu Leu Gly Ile Thr Glu 290 295 300 Asp Asp Val Gln Thr Arg Gly Leu Gln Val Thr Thr Thr Ile Asp Pro 305 310 315 320 Lys Thr Gln Glu Gly Ala Val Glu Ala Val Gln Asn Gln Leu Asp Leu 325 330 335 Leu Ser Glu Asn Asn Arg Ala Ala Val Val Ser Ile Asp Pro Ser Asn 340 345 350 Gly Ala Val Arg Ala Tyr Tyr Gly Gly Glu Asp Ala Thr Gly Trp Asp 355 360 365 Phe Ala Asn Ala Pro Leu Gln Thr Gly Ser Thr Phe Lys Ile Phe Gly 370 375 380 Leu Ala Ala Ala Leu Gln Gln Gly Ile Pro Leu Ser Gln Pro Tyr Ser 385 390 395 400 Ser Ala Pro Val Thr Val Gly Asp Ala Gln Ile Gly Asn Val Gly Gly 405 410 415 Ser Gly Cys Gly Ser Cys Ser Ile Glu Gln Ala Leu Leu His Ser Tyr 420 425 430 Asn Thr Ser Phe Ile Arg Leu Gln Gln Asp Leu Glu Asn Gly Ser Gln 435 440 445 Asp Thr Ala Asp Met Ala His Ala Leu Gly Ile Ala Lys Ser Leu Pro 450 455 460 Thr Ile Pro Glu Thr Leu Thr Glu Asn Gly Glu Thr Pro Tyr Glu Gly 465 470 475 480 Ile Ile Leu Gly Gln Tyr Glu Ser Arg Pro Leu Asp Met Ala Ser Ala 485 490 495 Met Ala Thr Ile Ala Asn Glu Gly Val Trp His Arg Pro His Phe Val 500 505 510 Ser Lys Val Glu Thr Val Ser Gly Glu Val Leu Tyr Glu Phe Glu Asp 515 520 525 Gly Asp Gly Glu Arg Arg Val Ser Glu Lys Val Ala Leu Asn Leu Leu 530 535 540 Lys Ala Met Gly Pro Ile Ala Ala Tyr Ser Asn Gly Asn Ala Leu Ala 545 550 555 560 Asp Gly Gln Val Ser Ala Ser Lys Thr Gly Thr Thr Gln Leu Gly Asp 565 570 575 Thr Gly Ala Asn Lys Asp Ala Trp Met Leu Gly Ala Ala Pro Gln Leu 580 585 590 Ala Thr Ala Val Trp Val Gly Thr Ala Asp Asn Thr Ala Leu Tyr Asn 595 600 605 Thr Trp Gly Gly Ser Met Tyr Gly Ser Asn Ser Pro Ala Thr Ile Trp 610 615 620 Lys Gln Thr Met Asp Asn Ala Leu Glu Asn Ser Pro Leu Glu Thr Trp 625 630 635 640 Asp Ile Ala Pro Ala Leu Gly Tyr Gly Asn Pro Pro Val Pro Glu Tyr 645 650 655 Val Trp Thr Pro Ser Pro Asn Ile Ala Thr Asn Asp Pro Glu Gly Ala 660 665 670 Thr Glu Glu Ala Pro Val Glu Asp Pro Asn Ala Val Ile Asp Thr Pro 675 680 685 Ala Val Asp Pro Thr Ala Pro Ala Glu Glu Thr Gly Asn Gly Gln Val 690 695 700 Glu Ile Leu Pro Gly Leu Thr Ile Pro Gly Asp Leu Leu Gly Ile Gly 705 710 715 720 <210> 67 <211> 1066 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1036) <223> RXA00552 <400> 67 ccgccaacaa ggcagcaaag ctcgatccaa ttgacgcctt gcgttatgag taaaagcctc 60 gtttttaagg tagccacaca tcgcactaga ctgaagaact gtg gct acc tca aaa 115 Val Ala Thr Ser Lys 1 5 att ctt ctt tat tac gca ttc acc ccg ctc tct gac cct aaa gcg gtt 163 Ile Leu Leu Tyr Tyr Ala Phe Thr Pro Leu Ser Asp Pro Lys Ala Val 10 15 20 cag ctg tgg cag cgt gag ctc tgc gag tca ctg aat ctt cgt ggc cgc 211 Gln Leu Trp Gln Arg Glu Leu Cys Glu Ser Leu Asn Leu Arg Gly Arg 25 30 35 atc ctg atc tcc act cac ggc atc aat gga acc gtg ggc gga gat att 259 Ile Leu Ile Ser Thr His Gly Ile Asn Gly Thr Val Gly Gly Asp Ile 40 45 50 gat gat tgc aag gcg tac att aaa aag acc cgc gag tac cca ggt ttc 307 Asp Asp Cys Lys Ala Tyr Ile Lys Lys Thr Arg Glu Tyr Pro Gly Phe 55 60 65 aac cgc atg cag ttt aag tgg tcc gag ggt ggc gct gag gat ttc cca 355 Asn Arg Met Gln Phe Lys Trp Ser Glu Gly Gly Ala Glu Asp Phe Pro 70 75 80 85 aag ctc agt gtc aaa gtc cgc gat gag atc gtt gcc ttc ggc gct cca 403 Lys Leu Ser Val Lys Val Arg Asp Glu Ile Val Ala Phe Gly Ala Pro 90 95 100 gat gag ctc aaa gtg gat gaa aac ggc gtc gtc ggt ggc ggc gtt cac 451 Asp Glu Leu Lys Val Asp Glu Asn Gly Val Val Gly Gly Gly Val His 105 110 115 ctg aaa cca cag cag gtc aat gag ctt gtg gaa gcc cgt ggc gat gaa 499 Leu Lys Pro Gln Gln Val Asn Glu Leu Val Glu Ala Arg Gly Asp Glu 120 125 130 gtt gtg ttc ttt gac ggc cgc aac gca atg gaa gcc cag atc ggc aag 547 Val Val Phe Phe Asp Gly Arg Asn Ala Met Glu Ala Gln Ile Gly Lys 135 140 145 ttc aag gac gct gtt gtc cct gac gta gaa acc act cat gat ttc atc 595 Phe Lys Asp Ala Val Val Pro Asp Val Glu Thr Thr His Asp Phe Ile 150 155 160 165 gca gaa att gag tct gga aaa tac gac gat ctc aaa gac aag cct gtg 643 Ala Glu Ile Glu Ser Gly Lys Tyr Asp Asp Leu Lys Asp Lys Pro Val 170 175 180 gtc acc tac tgc acc ggc gga att cgt tgt gag atc ctg agt tca ctc 691 Val Thr Tyr Cys Thr Gly Gly Ile Arg Cys Glu Ile Leu Ser Ser Leu 185 190 195 atg atc aac cgt ggt ttc aaa gag gtc tac caa atc gat ggc ggc atc 739 Met Ile Asn Arg Gly Phe Lys Glu Val Tyr Gln Ile Asp Gly Gly Ile 200 205 210 gtt cgc tac ggc gag cag ttt ggc aac aag ggc ctg tgg gaa ggc tcc 787 Val Arg Tyr Gly Glu Gln Phe Gly Asn Lys Gly Leu Trp Glu Gly Ser 215 220 225 ctc tac gtt ttc gat aag cgc atg cat atg gaa ttc ggc gag gat tac 835 Leu Tyr Val Phe Asp Lys Arg Met His Met Glu Phe Gly Glu Asp Tyr 230 235 240 245 aaa gag gtc gga cac tgc atc cat tgc gat act ccc acc aac aaa ttt 883 Lys Glu Val Gly His Cys Ile His Cys Asp Thr Pro Thr Asn Lys Phe 250 255 260 gag cac tgc ctc aac gaa gat gat tgc cgc gag ctc gtg ttg atg tgc 931 Glu His Cys Leu Asn Glu Asp Asp Cys Arg Glu Leu Val Leu Met Cys 265 270 275 cct gat tgc ttc gcc aat gtt gag acc cgt cat tgc aag cgc gaa cgc 979 Pro Asp Cys Phe Ala Asn Val Glu Thr Arg His Cys Lys Arg Glu Arg 280 285 290 tgt gca gca att gct gcg gat ttc gct gag caa gga att gat ccg ctc 1027 Cys Ala Ala Ile Ala Ala Asp Phe Ala Glu Gln Gly Ile Asp Pro Leu 295 300 305 gtt act tct taaaaagggt atggtggctg ggtatgagca 1066 Val Thr Ser 310 <210> 68 <211> 312 <212> PRT <213> Corynebacterium glutamicum <400> 68 Val Ala Thr Ser Lys Ile Leu Leu Tyr Tyr Ala Phe Thr Pro Leu Ser 1 5 10 15 Asp Pro Lys Ala Val Gln Leu Trp Gln Arg Glu Leu Cys Glu Ser Leu 20 25 30 Asn Leu Arg Gly Arg Ile Leu Ile Ser Thr His Gly Ile Asn Gly Thr 35 40 45 Val Gly Gly Asp Ile Asp Asp Cys Lys Ala Tyr Ile Lys Lys Thr Arg 50 55 60 Glu Tyr Pro Gly Phe Asn Arg Met Gln Phe Lys Trp Ser Glu Gly Gly 65 70 75 80 Ala Glu Asp Phe Pro Lys Leu Ser Val Lys Val Arg Asp Glu Ile Val 85 90 95 Ala Phe Gly Ala Pro Asp Glu Leu Lys Val Asp Glu Asn Gly Val Val 100 105 110 Gly Gly Gly Val His Leu Lys Pro Gln Gln Val Asn Glu Leu Val Glu 115 120 125 Ala Arg Gly Asp Glu Val Val Phe Phe Asp Gly Arg Asn Ala Met Glu 130 135 140 Ala Gln Ile Gly Lys Phe Lys Asp Ala Val Val Pro Asp Val Glu Thr 145 150 155 160 Thr His Asp Phe Ile Ala Glu Ile Glu Ser Gly Lys Tyr Asp Asp Leu 165 170 175 Lys Asp Lys Pro Val Val Thr Tyr Cys Thr Gly Gly Ile Arg Cys Glu 180 185 190 Ile Leu Ser Ser Leu Met Ile Asn Arg Gly Phe Lys Glu Val Tyr Gln 195 200 205 Ile Asp Gly Gly Ile Val Arg Tyr Gly Glu Gln Phe Gly Asn Lys Gly 210 215 220 Leu Trp Glu Gly Ser Leu Tyr Val Phe Asp Lys Arg Met His Met Glu 225 230 235 240 Phe Gly Glu Asp Tyr Lys Glu Val Gly His Cys Ile His Cys Asp Thr 245 250 255 Pro Thr Asn Lys Phe Glu His Cys Leu Asn Glu Asp Asp Cys Arg Glu 260 265 270 Leu Val Leu Met Cys Pro Asp Cys Phe Ala Asn Val Glu Thr Arg His 275 280 285 Cys Lys Arg Glu Arg Cys Ala Ala Ile Ala Ala Asp Phe Ala Glu Gln 290 295 300 Gly Ile Asp Pro Leu Val Thr Ser 305 310 <210> 69 <211> 952 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(922) <223> RXA00576 <400> 69 tgatgcccaa tttttgggcg accactggac gagggtgtgg gccctcgcgg cgtagggttt 60 ggagccactc cggtgggttt tcctgcaggt tcttgaactc ttg gtg agt caa tgc 115 Leu Val Ser Gln Cys 1 5 acc tgt ttg gaa ctc ctc tgg cgt ggc ggg caa aaa cag tcc gag ctt 163 Thr Cys Leu Glu Leu Leu Trp Arg Gly Gly Gln Lys Gln Ser Glu Leu 10 15 20 ctt agc ggc ggt ctg tgg ctt cat agc cct gcc cga tgg ctg gcg tac 211 Leu Ser Gly Gly Leu Trp Leu His Ser Pro Ala Arg Trp Leu Ala Tyr 25 30 35 aga ttc ttc gtt cac gcc cac aac ggt agc att gtt ttc atg ctg acc 259 Arg Phe Phe Val His Ala His Asn Gly Ser Ile Val Phe Met Leu Thr 40 45 50 tta agt ttc atc act ggc acg gag cca gga aag tgg ttt acc cga ttc 307 Leu Ser Phe Ile Thr Gly Thr Glu Pro Gly Lys Trp Phe Thr Arg Phe 55 60 65 cga gat cgg act cat cac ggt gga ctt gag acc ctt gat tcg gac gac 355 Arg Asp Arg Thr His His Gly Gly Leu Glu Thr Leu Asp Ser Asp Asp 70 75 80 85 gcc cta ggc ctc atg ctc gct ggc cag gca caa ctc gcc tta acc agg 403 Ala Leu Gly Leu Met Leu Ala Gly Gln Ala Gln Leu Ala Leu Thr Arg 90 95 100 ctt cca gat gcg cgt atc gac gcc tcc ctc cac gtg gtc act ctt tat 451 Leu Pro Asp Ala Arg Ile Asp Ala Ser Leu His Val Val Thr Leu Tyr 105 110 115 cag gaa caa ccc gga gtc gct ttt cca aaa gac ttt ttc ctc agt gcc 499 Gln Glu Gln Pro Gly Val Ala Phe Pro Lys Asp Phe Phe Leu Ser Ala 120 125 130 gaa gaa ggc gcg gtg gac ctt gcg gac tta gat ggg gag atc atc aac 547 Glu Glu Gly Ala Val Asp Leu Ala Asp Leu Asp Gly Glu Ile Ile Asn 135 140 145 tgg tcc atg ccc gat agt ggg gaa gtc gat gcc gct gct gtt cgc gat 595 Trp Ser Met Pro Asp Ser Gly Glu Val Asp Ala Ala Ala Val Arg Asp 150 155 160 165 gct ctg caa atc gtg gca gcg aac gtc ggt gtg gtg atc gcc ccc agg 643 Ala Leu Gln Ile Val Ala Ala Asn Val Gly Val Val Ile Ala Pro Arg 170 175 180 cca ctt ctc aag gtg ttg agc aag aaa ttg gtg gag cac cgg gac atc 691 Pro Leu Leu Lys Val Leu Ser Lys Lys Leu Val Glu His Arg Asp Ile 185 190 195 aag ggt gga act gaa aca tct atc gcc ctg gta tgg aag aaa gat gag 739 Lys Gly Gly Thr Glu Thr Ser Ile Ala Leu Val Trp Lys Lys Asp Glu 200 205 210 gat tct gaa gag att caa gac ttc gtc ggt att gct cgc ggt cga acg 787 Asp Ser Glu Glu Ile Gln Asp Phe Val Gly Ile Ala Arg Gly Arg Thr 215 220 225 cgg aat tcc agc agg cag caa acg gta aag ctc agt gct cgt gaa aaa 835 Arg Asn Ser Ser Arg Gln Gln Thr Val Lys Leu Ser Ala Arg Glu Lys 230 235 240 245 aca ctg gca aaa caa gcc cgc agg cag ggg gag aaa cca aaa act ccg 883 Thr Leu Ala Lys Gln Ala Arg Arg Gln Gly Glu Lys Pro Lys Thr Pro 250 255 260 aag cgt ccg cag gca aga aaa cgt ccc gga aaa cgg cga taggggtcac 932 Lys Arg Pro Gln Ala Arg Lys Arg Pro Gly Lys Arg Arg 265 270 ccgcgcatgt ccggttgccg 952 <210> 70 <211> 274 <212> PRT <213> Corynebacterium glutamicum <400> 70 Leu Val Ser Gln Cys Thr Cys Leu Glu Leu Leu Trp Arg Gly Gly Gln 1 5 10 15 Lys Gln Ser Glu Leu Leu Ser Gly Gly Leu Trp Leu His Ser Pro Ala 20 25 30 Arg Trp Leu Ala Tyr Arg Phe Phe Val His Ala His Asn Gly Ser Ile 35 40 45 Val Phe Met Leu Thr Leu Ser Phe Ile Thr Gly Thr Glu Pro Gly Lys 50 55 60 Trp Phe Thr Arg Phe Arg Asp Arg Thr His His Gly Gly Leu Glu Thr 65 70 75 80 Leu Asp Ser Asp Asp Ala Leu Gly Leu Met Leu Ala Gly Gln Ala Gln 85 90 95 Leu Ala Leu Thr Arg Leu Pro Asp Ala Arg Ile Asp Ala Ser Leu His 100 105 110 Val Val Thr Leu Tyr Gln Glu Gln Pro Gly Val Ala Phe Pro Lys Asp 115 120 125 Phe Phe Leu Ser Ala Glu Glu Gly Ala Val Asp Leu Ala Asp Leu Asp 130 135 140 Gly Glu Ile Ile Asn Trp Ser Met Pro Asp Ser Gly Glu Val Asp Ala 145 150 155 160 Ala Ala Val Arg Asp Ala Leu Gln Ile Val Ala Ala Asn Val Gly Val 165 170 175 Val Ile Ala Pro Arg Pro Leu Leu Lys Val Leu Ser Lys Lys Leu Val 180 185 190 Glu His Arg Asp Ile Lys Gly Gly Thr Glu Thr Ser Ile Ala Leu Val 195 200 205 Trp Lys Lys Asp Glu Asp Ser Glu Glu Ile Gln Asp Phe Val Gly Ile 210 215 220 Ala Arg Gly Arg Thr Arg Asn Ser Ser Arg Gln Gln Thr Val Lys Leu 225 230 235 240 Ser Ala Arg Glu Lys Thr Leu Ala Lys Gln Ala Arg Arg Gln Gly Glu 245 250 255 Lys Pro Lys Thr Pro Lys Arg Pro Gln Ala Arg Lys Arg Pro Gly Lys 260 265 270 Arg Arg <210> 71 <211> 1606 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1576) <223> RXA00611 <400> 71 ctttaaattg actatttaca aaactacttg atgagttagc aagagcacat ttcggtgcgc 60 ctccctgcta aacctcgaaa caataactag attgcacact atg tct gcc gct gct 115 Met Ser Ala Ala Ala 1 5 tct cga tca aga aac atc ttg act gcc ctc ctg cta ttg gtc ccg ctc 163 Ser Arg Ser Arg Asn Ile Leu Thr Ala Leu Leu Leu Leu Val Pro Leu 10 15 20 atc gca ggt acc atc tac gcc tcc gcc atg ggc ttg gac gtc tcc cgc 211 Ile Ala Gly Thr Ile Tyr Ala Ser Ala Met Gly Leu Asp Val Ser Arg 25 30 35 gca tgg tcc tca gca gat gaa gta acg ggg gca cct gca gcc tcc gta 259 Ala Trp Ser Ser Ala Asp Glu Val Thr Gly Ala Pro Ala Ala Ser Val 40 45 50 gcc acc aac aac cag gag ctt atc gaa gcc cgt cgc gcc gcc gga gaa 307 Ala Thr Asn Asn Gln Glu Leu Ile Glu Ala Arg Arg Ala Ala Gly Glu 55 60 65 gcc ggc gcc caa gcg ggg ttc ctc acc tca gga act gaa gag cta acc 355 Ala Gly Ala Gln Ala Gly Phe Leu Thr Ser Gly Thr Glu Glu Leu Thr 70 75 80 85 agc gga aca caa gag ctt atc gac ggc gca gcc cca ctc gaa gaa ggc 403 Ser Gly Thr Gln Glu Leu Ile Asp Gly Ala Ala Pro Leu Glu Glu Gly 90 95 100 gtc tca gcc gcg gct gac ggt gca gcg caa ctc cac gat ggc ctc atc 451 Val Ser Ala Ala Ala Asp Gly Ala Ala Gln Leu His Asp Gly Leu Ile 105 110 115 caa ctc cag gcc ggc act gga caa atg gga acc ggc gcc acc gaa att 499 Gln Leu Gln Ala Gly Thr Gly Gln Met Gly Thr Gly Ala Thr Glu Ile 120 125 130 gcc gac ggc gtc caa aac gca gtc gaa caa ctt ggc ggt ctt gtc gtt 547 Ala Asp Gly Val Gln Asn Ala Val Glu Gln Leu Gly Gly Leu Val Val 135 140 145 gta cag cag caa ctc tta ggc gcc ctc aac gaa gca gac aaa caa ctc 595 Val Gln Gln Gln Leu Leu Gly Ala Leu Asn Glu Ala Asp Lys Gln Leu 150 155 160 165 gcc tcg agc aaa atc ccc gaa gcc gaa gac ctg cgc aaa caa atc acc 643 Ala Ser Ser Lys Ile Pro Glu Ala Glu Asp Leu Arg Lys Gln Ile Thr 170 175 180 gaa gtc cga gga cac ctc gaa aac ttc ggc atc tcc gta gaa atg acc 691 Glu Val Arg Gly His Leu Glu Asn Phe Gly Ile Ser Val Glu Met Thr 185 190 195 gac caa ctc gat caa cta cgt tcc ggc acc cgc gac ctg gct aac caa 739 Asp Gln Leu Asp Gln Leu Arg Ser Gly Thr Arg Asp Leu Ala Asn Gln 200 205 210 ctc gca gtc ccc ggc tac gga ttc cac gat ggt att tac agc gcc acc 787 Leu Ala Val Pro Gly Tyr Gly Phe His Asp Gly Ile Tyr Ser Ala Thr 215 220 225 aat gga gca gcc gaa tta tct gca ggt ttg caa gag cta gaa gca ggc 835 Asn Gly Ala Ala Glu Leu Ser Ala Gly Leu Gln Glu Leu Glu Ala Gly 230 235 240 245 gtt ggg act gcc gtc gaa ggc ttc acc gca ctc gat gaa ggt gca aac 883 Val Gly Thr Ala Val Glu Gly Phe Thr Ala Leu Asp Glu Gly Ala Asn 250 255 260 cga tta gac tcc atg gcc acc ctc aac gaa gaa aaa acc tcc gca gtc 931 Arg Leu Asp Ser Met Ala Thr Leu Asn Glu Glu Lys Thr Ser Ala Val 265 270 275 caa cga gcc ctc ccg gta ccc caa gta ccc gcc ggc aca atc gaa ggc 979 Gln Arg Ala Leu Pro Val Pro Gln Val Pro Ala Gly Thr Ile Glu Gly 280 285 290 acc gca gac gaa gaa cgc acc agc gca cta gcg ccc atg tac gcc ttc 1027 Thr Ala Asp Glu Glu Arg Thr Ser Ala Leu Ala Pro Met Tyr Ala Phe 295 300 305 tta att tca gca ttg gtc atg ctg gcc ggt gca gca ctt gga tgg gca 1075 Leu Ile Ser Ala Leu Val Met Leu Ala Gly Ala Ala Leu Gly Trp Ala 310 315 320 325 aca cta aaa aac aag tgg ctg atg gcc ttt gct gtc att ggt gtc act 1123 Thr Leu Lys Asn Lys Trp Leu Met Ala Phe Ala Val Ile Gly Val Thr 330 335 340 gca atc ggt ggc att atc ttg ttc acc gta gct ttg ggc ata tcc att 1171 Ala Ile Gly Gly Ile Ile Leu Phe Thr Val Ala Leu Gly Ile Ser Ile 345 350 355 gga gct ttg ttt gga gcc tta gga att ttg ctt ctt gcc act gtt gtt 1219 Gly Ala Leu Phe Gly Ala Leu Gly Ile Leu Leu Leu Ala Thr Val Val 360 365 370 gcc ggt att ctc tcc cgg att ttg ctt gac gtg ttg gga act acc ggg 1267 Ala Gly Ile Leu Ser Arg Ile Leu Leu Asp Val Leu Gly Thr Thr Gly 375 380 385 gct att gtg gtt tct gtt ctg gga tgg gta gcc caa gct gca gta att 1315 Ala Ile Val Val Ser Val Leu Gly Trp Val Ala Gln Ala Ala Val Ile 390 395 400 405 ggc cat gta tgg agt gtt acc gct gta tcc gat atc gca ctt gtt tgg 1363 Gly His Val Trp Ser Val Thr Ala Val Ser Asp Ile Ala Leu Val Trp 410 415 420 cga gtc gtc gca ggc atg atg cca ctg cat tat cca acc ttt gca gtg 1411 Arg Val Val Ala Gly Met Met Pro Leu His Tyr Pro Thr Phe Ala Val 425 430 435 acc tcc att ggt aat ggc gga tca gct gca gct atc tgg atg tct gtt 1459 Thr Ser Ile Gly Asn Gly Gly Ser Ala Ala Ala Ile Trp Met Ser Val 440 445 450 gct gtc ttg ttg gca atg gga gcg atc gga gct gtt gcg ctt cgg aag 1507 Ala Val Leu Leu Ala Met Gly Ala Ile Gly Ala Val Ala Leu Arg Lys 455 460 465 cca aag gcg gtt gcg gtt gag gtt gaa gaa gct gtt gat gct gat gca 1555 Pro Lys Ala Val Ala Val Glu Val Glu Glu Ala Val Asp Ala Asp Ala 470 475 480 485 gac caa gca gcc tcg gaa tcc tgatggtttt ggtctgattc gacctgttct 1606 Asp Gln Ala Ala Ser Glu Ser 490 <210> 72 <211> 492 <212> PRT <213> Corynebacterium glutamicum <400> 72 Met Ser Ala Ala Ala Ser Arg Ser Arg Asn Ile Leu Thr Ala Leu Leu 1 5 10 15 Leu Leu Val Pro Leu Ile Ala Gly Thr Ile Tyr Ala Ser Ala Met Gly 20 25 30 Leu Asp Val Ser Arg Ala Trp Ser Ser Ala Asp Glu Val Thr Gly Ala 35 40 45 Pro Ala Ala Ser Val Ala Thr Asn Asn Gln Glu Leu Ile Glu Ala Arg 50 55 60 Arg Ala Ala Gly Glu Ala Gly Ala Gln Ala Gly Phe Leu Thr Ser Gly 65 70 75 80 Thr Glu Glu Leu Thr Ser Gly Thr Gln Glu Leu Ile Asp Gly Ala Ala 85 90 95 Pro Leu Glu Glu Gly Val Ser Ala Ala Ala Asp Gly Ala Ala Gln Leu 100 105 110 His Asp Gly Leu Ile Gln Leu Gln Ala Gly Thr Gly Gln Met Gly Thr 115 120 125 Gly Ala Thr Glu Ile Ala Asp Gly Val Gln Asn Ala Val Glu Gln Leu 130 135 140 Gly Gly Leu Val Val Val Gln Gln Gln Leu Leu Gly Ala Leu Asn Glu 145 150 155 160 Ala Asp Lys Gln Leu Ala Ser Ser Lys Ile Pro Glu Ala Glu Asp Leu 165 170 175 Arg Lys Gln Ile Thr Glu Val Arg Gly His Leu Glu Asn Phe Gly Ile 180 185 190 Ser Val Glu Met Thr Asp Gln Leu Asp Gln Leu Arg Ser Gly Thr Arg 195 200 205 Asp Leu Ala Asn Gln Leu Ala Val Pro Gly Tyr Gly Phe His Asp Gly 210 215 220 Ile Tyr Ser Ala Thr Asn Gly Ala Ala Glu Leu Ser Ala Gly Leu Gln 225 230 235 240 Glu Leu Glu Ala Gly Val Gly Thr Ala Val Glu Gly Phe Thr Ala Leu 245 250 255 Asp Glu Gly Ala Asn Arg Leu Asp Ser Met Ala Thr Leu Asn Glu Glu 260 265 270 Lys Thr Ser Ala Val Gln Arg Ala Leu Pro Val Pro Gln Val Pro Ala 275 280 285 Gly Thr Ile Glu Gly Thr Ala Asp Glu Glu Arg Thr Ser Ala Leu Ala 290 295 300 Pro Met Tyr Ala Phe Leu Ile Ser Ala Leu Val Met Leu Ala Gly Ala 305 310 315 320 Ala Leu Gly Trp Ala Thr Leu Lys Asn Lys Trp Leu Met Ala Phe Ala 325 330 335 Val Ile Gly Val Thr Ala Ile Gly Gly Ile Ile Leu Phe Thr Val Ala 340 345 350 Leu Gly Ile Ser Ile Gly Ala Leu Phe Gly Ala Leu Gly Ile Leu Leu 355 360 365 Leu Ala Thr Val Val Ala Gly Ile Leu Ser Arg Ile Leu Leu Asp Val 370 375 380 Leu Gly Thr Thr Gly Ala Ile Val Val Ser Val Leu Gly Trp Val Ala 385 390 395 400 Gln Ala Ala Val Ile Gly His Val Trp Ser Val Thr Ala Val Ser Asp 405 410 415 Ile Ala Leu Val Trp Arg Val Val Ala Gly Met Met Pro Leu His Tyr 420 425 430 Pro Thr Phe Ala Val Thr Ser Ile Gly Asn Gly Gly Ser Ala Ala Ala 435 440 445 Ile Trp Met Ser Val Ala Val Leu Leu Ala Met Gly Ala Ile Gly Ala 450 455 460 Val Ala Leu Arg Lys Pro Lys Ala Val Ala Val Glu Val Glu Glu Ala 465 470 475 480 Val Asp Ala Asp Ala Asp Gln Ala Ala Ser Glu Ser 485 490 <210> 73 <211> 1045 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1015) <223> RXA00614 <400> 73 cagtggtgtc cttgtcgcgg gccttcatag cggtggtcag atctgcgcgg attttgtctt 60 ttagttcact catgtttgcc cagagtactc cccaggtagg gtg aat aag gtg tca 115 Val Asn Lys Val Ser 1 5 act atc gct aaa aca ctc act ttt tca agt gca gcc cta ctc gga gct 163 Thr Ile Ala Lys Thr Leu Thr Phe Ser Ser Ala Ala Leu Leu Gly Ala 10 15 20 ggt atc gcc acc gct gca tgg gga tac tca gag ctc aaa aaa ttc gag 211 Gly Ile Ala Thr Ala Ala Trp Gly Tyr Ser Glu Leu Lys Lys Phe Glu 25 30 35 ctc aaa aca gta gaa ctg cca att ttg aag cct gga acg ctc cgt gga 259 Leu Lys Thr Val Glu Leu Pro Ile Leu Lys Pro Gly Thr Leu Arg Gly 40 45 50 aag aag gaa ttc cgc ctt ctc cac atc tct gat ctc cac atg atc cca 307 Lys Lys Glu Phe Arg Leu Leu His Ile Ser Asp Leu His Met Ile Pro 55 60 65 ggc caa gaa acc aaa aaa gca tgg gtc tcc gca ctc gat tca cta agc 355 Gly Gln Glu Thr Lys Lys Ala Trp Val Ser Ala Leu Asp Ser Leu Ser 70 75 80 85 ccc gat ttg gtg atc aac acc ggt gac aac ctt agc gat gaa aaa gca 403 Pro Asp Leu Val Ile Asn Thr Gly Asp Asn Leu Ser Asp Glu Lys Ala 90 95 100 gtc ccc gac gtc ctc cgc gca ctc ggc cca ctg atg aac cgc ccc ggc 451 Val Pro Asp Val Leu Arg Ala Leu Gly Pro Leu Met Asn Arg Pro Gly 105 110 115 gcg ttc gtc ttc gga acc aac gat tac tgg gca ccc cgc ccc gtc aat 499 Ala Phe Val Phe Gly Thr Asn Asp Tyr Trp Ala Pro Arg Pro Val Asn 120 125 130 cct ttc ggc tac ctc ttc ggt aaa aaa cgc gaa gtg agc cac atc gac 547 Pro Phe Gly Tyr Leu Phe Gly Lys Lys Arg Glu Val Ser His Ile Asp 135 140 145 ctc ccc tgg cga gcc atg cga gct gct ttc atc gaa cac gga tgg caa 595 Leu Pro Trp Arg Ala Met Arg Ala Ala Phe Ile Glu His Gly Trp Gln 150 155 160 165 gac gcc aac caa aag cga ctc gaa ttc caa gta ggt tcc gtc cgc ctc 643 Asp Ala Asn Gln Lys Arg Leu Glu Phe Gln Val Gly Ser Val Arg Leu 170 175 180 gcc atc tca ggt gtt gat gac ccc cac cat gac ctc gac gac tac aca 691 Ala Ile Ser Gly Val Asp Asp Pro His His Asp Leu Asp Asp Tyr Thr 185 190 195 gag atc gca ggg gca cca aac gtg gac gct gat ctg tcc ata gcg ttg 739 Glu Ile Ala Gly Ala Pro Asn Val Asp Ala Asp Leu Ser Ile Ala Leu 200 205 210 ctt cac gca cca gaa cct cga gtc ctc gct cag ttc gaa gcc gac ggc 787 Leu His Ala Pro Glu Pro Arg Val Leu Ala Gln Phe Glu Ala Asp Gly 215 220 225 tac cag ctt tcc ctc tcc ggc cac acc cac ggc ggt cag ctt tgt ctt 835 Tyr Gln Leu Ser Leu Ser Gly His Thr His Gly Gly Gln Leu Cys Leu 230 235 240 245 ccg ggc agc aag cca att gtc acc aac tgt gga atc gac cgc aaa cgc 883 Pro Gly Ser Lys Pro Ile Val Thr Asn Cys Gly Ile Asp Arg Lys Arg 250 255 260 gcc acc ggc ctc aac aaa ttt ggc gac atg tgg atg cac gtt tcc aac 931 Ala Thr Gly Leu Asn Lys Phe Gly Asp Met Trp Met His Val Ser Asn 265 270 275 ggc ctc ggc acc tca aaa ttc gtc cca ttc cgc atc ttc tgc cga ccc 979 Gly Leu Gly Thr Ser Lys Phe Val Pro Phe Arg Ile Phe Cys Arg Pro 280 285 290 agc gcc acc cta ata aag atc act gaa cag gca ctt tgacctgaaa 1025 Ser Ala Thr Leu Ile Lys Ile Thr Glu Gln Ala Leu 295 300 305 aacccacagg actacagtga 1045 <210> 74 <211> 305 <212> PRT <213> Corynebacterium glutamicum <400> 74 Val Asn Lys Val Ser Thr Ile Ala Lys Thr Leu Thr Phe Ser Ser Ala 1 5 10 15 Ala Leu Leu Gly Ala Gly Ile Ala Thr Ala Ala Trp Gly Tyr Ser Glu 20 25 30 Leu Lys Lys Phe Glu Leu Lys Thr Val Glu Leu Pro Ile Leu Lys Pro 35 40 45 Gly Thr Leu Arg Gly Lys Lys Glu Phe Arg Leu Leu His Ile Ser Asp 50 55 60 Leu His Met Ile Pro Gly Gln Glu Thr Lys Lys Ala Trp Val Ser Ala 65 70 75 80 Leu Asp Ser Leu Ser Pro Asp Leu Val Ile Asn Thr Gly Asp Asn Leu 85 90 95 Ser Asp Glu Lys Ala Val Pro Asp Val Leu Arg Ala Leu Gly Pro Leu 100 105 110 Met Asn Arg Pro Gly Ala Phe Val Phe Gly Thr Asn Asp Tyr Trp Ala 115 120 125 Pro Arg Pro Val Asn Pro Phe Gly Tyr Leu Phe Gly Lys Lys Arg Glu 130 135 140 Val Ser His Ile Asp Leu Pro Trp Arg Ala Met Arg Ala Ala Phe Ile 145 150 155 160 Glu His Gly Trp Gln Asp Ala Asn Gln Lys Arg Leu Glu Phe Gln Val 165 170 175 Gly Ser Val Arg Leu Ala Ile Ser Gly Val Asp Asp Pro His His Asp 180 185 190 Leu Asp Asp Tyr Thr Glu Ile Ala Gly Ala Pro Asn Val Asp Ala Asp 195 200 205 Leu Ser Ile Ala Leu Leu His Ala Pro Glu Pro Arg Val Leu Ala Gln 210 215 220 Phe Glu Ala Asp Gly Tyr Gln Leu Ser Leu Ser Gly His Thr His Gly 225 230 235 240 Gly Gln Leu Cys Leu Pro Gly Ser Lys Pro Ile Val Thr Asn Cys Gly 245 250 255 Ile Asp Arg Lys Arg Ala Thr Gly Leu Asn Lys Phe Gly Asp Met Trp 260 265 270 Met His Val Ser Asn Gly Leu Gly Thr Ser Lys Phe Val Pro Phe Arg 275 280 285 Ile Phe Cys Arg Pro Ser Ala Thr Leu Ile Lys Ile Thr Glu Gln Ala 290 295 300 Leu 305 <210> 75 <211> 883 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(853) <223> RXA00637 <400> 75 ccgatggcac tttccgtacc tggaaggtag ttgcccgcgg cagaaacaat tagggaaacc 60 tcttgacctt cacgcgacgt caaggattta actaacagtc atg aca gat cga acc 115 Met Thr Asp Arg Thr 1 5 att ggc gag gct gct gaa cta ctc ggt gtc acc acc cgc aca ctg cgg 163 Ile Gly Glu Ala Ala Glu Leu Leu Gly Val Thr Thr Arg Thr Leu Arg 10 15 20 cat tgg gac agc atc ggg ttg ctt caa ccg agc tgg cga acc aca acg 211 His Trp Asp Ser Ile Gly Leu Leu Gln Pro Ser Trp Arg Thr Thr Thr 25 30 35 gat tat cgc ctt tac aca gaa gac gat gtc gag cgc gcc ctg cag att 259 Asp Tyr Arg Leu Tyr Thr Glu Asp Asp Val Glu Arg Ala Leu Gln Ile 40 45 50 ctt att tac agg gcc gcc gga atc ggg ttg aag gat att gcg gag gtg 307 Leu Ile Tyr Arg Ala Ala Gly Ile Gly Leu Lys Asp Ile Ala Glu Val 55 60 65 ctt gat cag ccg gat tcg gcc aat cag cac ctg cgc cgc cag cgg gaa 355 Leu Asp Gln Pro Asp Ser Ala Asn Gln His Leu Arg Arg Gln Arg Glu 70 75 80 85 ctc cta gtg gaa cag atc ggt cag ctg cat cgg atg gtc cgg gca gta 403 Leu Leu Val Glu Gln Ile Gly Gln Leu His Arg Met Val Arg Ala Val 90 95 100 gat gaa atc ctt gga aag gat gcg att agc gtg aag gaa aag att gag 451 Asp Glu Ile Leu Gly Lys Asp Ala Ile Ser Val Lys Glu Lys Ile Glu 105 110 115 atc ttc ggc gag gat ctg ccc aag tac caa gag gag gct ttc cag cgc 499 Ile Phe Gly Glu Asp Leu Pro Lys Tyr Gln Glu Glu Ala Phe Gln Arg 120 125 130 tgg ggc gac acc ccg gag tgg aaa gaa tcc caa aag atc cag gag aag 547 Trp Gly Asp Thr Pro Glu Trp Lys Glu Ser Gln Lys Ile Gln Glu Lys 135 140 145 atg acc aag gag gat ttt cag agg gcg aaa gat gaa cat gag ggg ttc 595 Met Thr Lys Glu Asp Phe Gln Arg Ala Lys Asp Glu His Glu Gly Phe 150 155 160 165 gtc gaa aag ctt atc gac gcc tcc ctg cgc ggc atc gcg ccc ggc tct 643 Val Glu Lys Leu Ile Asp Ala Ser Leu Arg Gly Ile Ala Pro Gly Ser 170 175 180 gca gag ggc aat gag cta gcg ctt gcg cac cgc gca agc atc ggt cag 691 Ala Glu Gly Asn Glu Leu Ala Leu Ala His Arg Ala Ser Ile Gly Gln 185 190 195 tgg tac acc gtg agt gca aac aag caa gta att ttg gct cgg atg tac 739 Trp Tyr Thr Val Ser Ala Asn Lys Gln Val Ile Leu Ala Arg Met Tyr 200 205 210 gtg gaa gac gag cgt ttt aac gaa act tac aaa gga cac gcc tca tat 787 Val Glu Asp Glu Arg Phe Asn Glu Thr Tyr Lys Gly His Ala Ser Tyr 215 220 225 ctt tta aca ctt att gaa gca ttg gcg cag gta gaa ggc gtg gac ttg 835 Leu Leu Thr Leu Ile Glu Ala Leu Ala Gln Val Glu Gly Val Asp Leu 230 235 240 245 gag aat gtg gag tgg gaa taatcccaat ttcaactctt tcagtacatt 883 Glu Asn Val Glu Trp Glu 250 <210> 76 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 76 Met Thr Asp Arg Thr Ile Gly Glu Ala Ala Glu Leu Leu Gly Val Thr 1 5 10 15 Thr Arg Thr Leu Arg His Trp Asp Ser Ile Gly Leu Leu Gln Pro Ser 20 25 30 Trp Arg Thr Thr Thr Asp Tyr Arg Leu Tyr Thr Glu Asp Asp Val Glu 35 40 45 Arg Ala Leu Gln Ile Leu Ile Tyr Arg Ala Ala Gly Ile Gly Leu Lys 50 55 60 Asp Ile Ala Glu Val Leu Asp Gln Pro Asp Ser Ala Asn Gln His Leu 65 70 75 80 Arg Arg Gln Arg Glu Leu Leu Val Glu Gln Ile Gly Gln Leu His Arg 85 90 95 Met Val Arg Ala Val Asp Glu Ile Leu Gly Lys Asp Ala Ile Ser Val 100 105 110 Lys Glu Lys Ile Glu Ile Phe Gly Glu Asp Leu Pro Lys Tyr Gln Glu 115 120 125 Glu Ala Phe Gln Arg Trp Gly Asp Thr Pro Glu Trp Lys Glu Ser Gln 130 135 140 Lys Ile Gln Glu Lys Met Thr Lys Glu Asp Phe Gln Arg Ala Lys Asp 145 150 155 160 Glu His Glu Gly Phe Val Glu Lys Leu Ile Asp Ala Ser Leu Arg Gly 165 170 175 Ile Ala Pro Gly Ser Ala Glu Gly Asn Glu Leu Ala Leu Ala His Arg 180 185 190 Ala Ser Ile Gly Gln Trp Tyr Thr Val Ser Ala Asn Lys Gln Val Ile 195 200 205 Leu Ala Arg Met Tyr Val Glu Asp Glu Arg Phe Asn Glu Thr Tyr Lys 210 215 220 Gly His Ala Ser Tyr Leu Leu Thr Leu Ile Glu Ala Leu Ala Gln Val 225 230 235 240 Glu Gly Val Asp Leu Glu Asn Val Glu Trp Glu 245 250 <210> 77 <211> 1432 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1402) <223> RXA00654 <400> 77 gagatcaatt catatctcaa acattgtaca tctgatcagc aatagcgatt attgcttgat 60 tgtgtgtttt tagatcttcg gttctcttca ctcaactgct gtg aag tgc cac ctg 115 Val Lys Cys His Leu 1 5 ttt gga aag gcg aac acg ata gtg ctc gat att ttg att tac ccg gtg 163 Phe Gly Lys Ala Asn Thr Ile Val Leu Asp Ile Leu Ile Tyr Pro Val 10 15 20 tct gga gtg atg aag ctg tgg cac ctg ctt ctt cac aac gtt gcg ggt 211 Ser Gly Val Met Lys Leu Trp His Leu Leu Leu His Asn Val Ala Gly 25 30 35 ttg gac gat tca ctg gcg tgg ttc ttt tcc ctt ttc ggc ctt gtc atc 259 Leu Asp Asp Ser Leu Ala Trp Phe Phe Ser Leu Phe Gly Leu Val Ile 40 45 50 acg atc cgt gca att atc gcg cct ttc acc tgg cag atg tat aag tcg 307 Thr Ile Arg Ala Ile Ile Ala Pro Phe Thr Trp Gln Met Tyr Lys Ser 55 60 65 ggc cgc act gcc gca cat att cgt cct cac cgc gct gcg ctc cgg gaa 355 Gly Arg Thr Ala Ala His Ile Arg Pro His Arg Ala Ala Leu Arg Glu 70 75 80 85 gaa tac aag gga aag tac gat gaa gcg tcc att cgg gag ttg cag aag 403 Glu Tyr Lys Gly Lys Tyr Asp Glu Ala Ser Ile Arg Glu Leu Gln Lys 90 95 100 cgc cag aat gat ttg aat aag gaa tac ggc att aac ccg ctg gca ggt 451 Arg Gln Asn Asp Leu Asn Lys Glu Tyr Gly Ile Asn Pro Leu Ala Gly 105 110 115 tgt gtg cct ggg ctg atc cag ata ccg att gtc ctt ggt ctt tac tgg 499 Cys Val Pro Gly Leu Ile Gln Ile Pro Ile Val Leu Gly Leu Tyr Trp 120 125 130 gca ctt ctc cgc atg gct cgc cct gaa ggt ggt ttg gaa aat ccc gtc 547 Ala Leu Leu Arg Met Ala Arg Pro Glu Gly Gly Leu Glu Asn Pro Val 135 140 145 ttc cag tcg atc ggc ttc cta act cct gag gaa gtg gaa tct ttc ctc 595 Phe Gln Ser Ile Gly Phe Leu Thr Pro Glu Glu Val Glu Ser Phe Leu 150 155 160 165 gct ggt cgc gtg agc aat gtg cct ctg ccc gct tat gtt tcg atg ccc 643 Ala Gly Arg Val Ser Asn Val Pro Leu Pro Ala Tyr Val Ser Met Pro 170 175 180 act gag cag cta aaa tat ttg agc acc acg cag gcg gaa gtt ctt agt 691 Thr Glu Gln Leu Lys Tyr Leu Ser Thr Thr Gln Ala Glu Val Leu Ser 185 190 195 ttc gtt ttg cca ctg ttc atc aca gcc gca atc ctc acc gca atc aac 739 Phe Val Leu Pro Leu Phe Ile Thr Ala Ala Ile Leu Thr Ala Ile Asn 200 205 210 atg gcg atg tcc atg tac cgc agc ttc caa acc aac gat tac gca tcc 787 Met Ala Met Ser Met Tyr Arg Ser Phe Gln Thr Asn Asp Tyr Ala Ser 215 220 225 gga ttc tct aac ggc atg ctg aag ttc atg atc gtg atg tcg atc ctc 835 Gly Phe Ser Asn Gly Met Leu Lys Phe Met Ile Val Met Ser Ile Leu 230 235 240 245 gcg ccg atc ttc cca ctg tcc ctt ggc ctc aca gga cca ttc ccc aca 883 Ala Pro Ile Phe Pro Leu Ser Leu Gly Leu Thr Gly Pro Phe Pro Thr 250 255 260 gca atc gca ctc tat tgg gtc agc aac aac ctg tgg acg ctc ctc caa 931 Ala Ile Ala Leu Tyr Trp Val Ser Asn Asn Leu Trp Thr Leu Leu Gln 265 270 275 aca atc atc atg atg gtc att ttg gaa cgc aaa tac cca ctt acc gac 979 Thr Ile Ile Met Met Val Ile Leu Glu Arg Lys Tyr Pro Leu Thr Asp 280 285 290 gat ttc aaa gtg cac cac cta gag cag cgc gac atc tac cgc gca aaa 1027 Asp Phe Lys Val His His Leu Glu Gln Arg Asp Ile Tyr Arg Ala Lys 295 300 305 caa aaa gaa aag cgc atc ttc ctg tgg aca cga cgc aaa aac cgc gcc 1075 Gln Lys Glu Lys Arg Ile Phe Leu Trp Thr Arg Arg Lys Asn Arg Ala 310 315 320 325 ctg atg att ctc acc cca tgg aac gcc tca acg ctt cac gca aca aac 1123 Leu Met Ile Leu Thr Pro Trp Asn Ala Ser Thr Leu His Ala Thr Asn 330 335 340 gtg gaa ctc acc aaa acc cgt act gcc gaa atc aac gaa gca aaa cag 1171 Val Glu Leu Thr Lys Thr Arg Thr Ala Glu Ile Asn Glu Ala Lys Gln 345 350 355 gcc cgc aaa gaa atc gcg aac aag agg cgc gaa acg caa cgt gaa atg 1219 Ala Arg Lys Glu Ile Ala Asn Lys Arg Arg Glu Thr Gln Arg Glu Met 360 365 370 aac cgc gcc gcc atg cag cgc tta aag cag cgt cgc gct gag gtt aaa 1267 Asn Arg Ala Ala Met Gln Arg Leu Lys Gln Arg Arg Ala Glu Val Lys 375 380 385 gct aaa aag aag ggg ctt atc gac gcc tcc ccc aac gaa gat acc cct 1315 Ala Lys Lys Lys Gly Leu Ile Asp Ala Ser Pro Asn Glu Asp Thr Pro 390 395 400 405 tcg gaa aat gaa gaa act aaa ttg agt agt ccg cag gtg gag ccg aca 1363 Ser Glu Asn Glu Glu Thr Lys Leu Ser Ser Pro Gln Val Glu Pro Thr 410 415 420 aca act gcc gag cca aat cgc gag ccg tct caa gag gac tgatgttgtg 1412 Thr Thr Ala Glu Pro Asn Arg Glu Pro Ser Gln Glu Asp 425 430 gaccaatcga gatccagcaa 1432 <210> 78 <211> 434 <212> PRT <213> Corynebacterium glutamicum <400> 78 Val Lys Cys His Leu Phe Gly Lys Ala Asn Thr Ile Val Leu Asp Ile 1 5 10 15 Leu Ile Tyr Pro Val Ser Gly Val Met Lys Leu Trp His Leu Leu Leu 20 25 30 His Asn Val Ala Gly Leu Asp Asp Ser Leu Ala Trp Phe Phe Ser Leu 35 40 45 Phe Gly Leu Val Ile Thr Ile Arg Ala Ile Ile Ala Pro Phe Thr Trp 50 55 60 Gln Met Tyr Lys Ser Gly Arg Thr Ala Ala His Ile Arg Pro His Arg 65 70 75 80 Ala Ala Leu Arg Glu Glu Tyr Lys Gly Lys Tyr Asp Glu Ala Ser Ile 85 90 95 Arg Glu Leu Gln Lys Arg Gln Asn Asp Leu Asn Lys Glu Tyr Gly Ile 100 105 110 Asn Pro Leu Ala Gly Cys Val Pro Gly Leu Ile Gln Ile Pro Ile Val 115 120 125 Leu Gly Leu Tyr Trp Ala Leu Leu Arg Met Ala Arg Pro Glu Gly Gly 130 135 140 Leu Glu Asn Pro Val Phe Gln Ser Ile Gly Phe Leu Thr Pro Glu Glu 145 150 155 160 Val Glu Ser Phe Leu Ala Gly Arg Val Ser Asn Val Pro Leu Pro Ala 165 170 175 Tyr Val Ser Met Pro Thr Glu Gln Leu Lys Tyr Leu Ser Thr Thr Gln 180 185 190 Ala Glu Val Leu Ser Phe Val Leu Pro Leu Phe Ile Thr Ala Ala Ile 195 200 205 Leu Thr Ala Ile Asn Met Ala Met Ser Met Tyr Arg Ser Phe Gln Thr 210 215 220 Asn Asp Tyr Ala Ser Gly Phe Ser Asn Gly Met Leu Lys Phe Met Ile 225 230 235 240 Val Met Ser Ile Leu Ala Pro Ile Phe Pro Leu Ser Leu Gly Leu Thr 245 250 255 Gly Pro Phe Pro Thr Ala Ile Ala Leu Tyr Trp Val Ser Asn Asn Leu 260 265 270 Trp Thr Leu Leu Gln Thr Ile Ile Met Met Val Ile Leu Glu Arg Lys 275 280 285 Tyr Pro Leu Thr Asp Asp Phe Lys Val His His Leu Glu Gln Arg Asp 290 295 300 Ile Tyr Arg Ala Lys Gln Lys Glu Lys Arg Ile Phe Leu Trp Thr Arg 305 310 315 320 Arg Lys Asn Arg Ala Leu Met Ile Leu Thr Pro Trp Asn Ala Ser Thr 325 330 335 Leu His Ala Thr Asn Val Glu Leu Thr Lys Thr Arg Thr Ala Glu Ile 340 345 350 Asn Glu Ala Lys Gln Ala Arg Lys Glu Ile Ala Asn Lys Arg Arg Glu 355 360 365 Thr Gln Arg Glu Met Asn Arg Ala Ala Met Gln Arg Leu Lys Gln Arg 370 375 380 Arg Ala Glu Val Lys Ala Lys Lys Lys Gly Leu Ile Asp Ala Ser Pro 385 390 395 400 Asn Glu Asp Thr Pro Ser Glu Asn Glu Glu Thr Lys Leu Ser Ser Pro 405 410 415 Gln Val Glu Pro Thr Thr Thr Ala Glu Pro Asn Arg Glu Pro Ser Gln 420 425 430 Glu Asp <210> 79 <211> 865 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(835) <223> RXA00678 <400> 79 tgcgcagtgc actttccagg aaccaaaata tccccgccga ccttgctgca gatatttcgc 60 agccgctgaa aaaactagcc gttgacctgg aggttacccg atg act cgc agt aat 115 Met Thr Arg Ser Asn 1 5 tta ccc gct tgg gag caa gca gac ccc agc gtc cac gcc tct gat ccc 163 Leu Pro Ala Trp Glu Gln Ala Asp Pro Ser Val His Ala Ser Asp Pro 10 15 20 cgc gcc atc act ttt gcg gag gat ttt ggg att cgt ccc atc ccg gcc 211 Arg Ala Ile Thr Phe Ala Glu Asp Phe Gly Ile Arg Pro Ile Pro Ala 25 30 35 gta ggt cca att gat acc acc gct atc tgt gca aca cct tca aat gga 259 Val Gly Pro Ile Asp Thr Thr Ala Ile Cys Ala Thr Pro Ser Asn Gly 40 45 50 ttt gag caa tta tgg aaa gcc att gag ccg gaa acc cgc acc cgc gcc 307 Phe Glu Gln Leu Trp Lys Ala Ile Glu Pro Glu Thr Arg Thr Arg Ala 55 60 65 aac gac att cat ctt ccc atc gtc gtg gcg tac gct gaa cgt ctc tgc 355 Asn Asp Ile His Leu Pro Ile Val Val Ala Tyr Ala Glu Arg Leu Cys 70 75 80 85 gac gct tac cca ctg gca gat aga gaa ttg gtt ctc gta gcc gca atc 403 Asp Ala Tyr Pro Leu Ala Asp Arg Glu Leu Val Leu Val Ala Ala Ile 90 95 100 ctc cac gac acg ggc tgg gca cat gtc gat gag agc cga atc atc tcc 451 Leu His Asp Thr Gly Trp Ala His Val Asp Glu Ser Arg Ile Ile Ser 105 110 115 gaa gga ttc tcc gga aac tgg cgc aaa gca gca atc cgc ttc gaa cac 499 Glu Gly Phe Ser Gly Asn Trp Arg Lys Ala Ala Ile Arg Phe Glu His 120 125 130 gaa aca gaa ggc tgc act gtg gcc cgc cga gtg ctt cca tcc ctc gga 547 Glu Thr Glu Gly Cys Thr Val Ala Arg Arg Val Leu Pro Ser Leu Gly 135 140 145 tat act gtc gat ttt gtc gag cat gtc tgc gac atc atc gac gga cac 595 Tyr Thr Val Asp Phe Val Glu His Val Cys Asp Ile Ile Asp Gly His 150 155 160 165 gac acc cgc caa gtg gcc tac tca cta gaa gac gct ctt gtt cgc gat 643 Asp Thr Arg Gln Val Ala Tyr Ser Leu Glu Asp Ala Leu Val Arg Asp 170 175 180 tgc gac cga ctc tgg cgt ttc gac cgc gcc ggg atc acg gct tct agc 691 Cys Asp Arg Leu Trp Arg Phe Asp Arg Ala Gly Ile Thr Ala Ser Ser 185 190 195 tca tgg ttc ggg atg cca gtc tca gat tat gtc gac cgc ctg cac agg 739 Ser Trp Phe Gly Met Pro Val Ser Asp Tyr Val Asp Arg Leu His Arg 200 205 210 gaa atc ctc cca gaa tta atc acc gaa gct gca cac cag atg gct act 787 Glu Ile Leu Pro Glu Leu Ile Thr Glu Ala Ala His Gln Met Ala Thr 215 220 225 gca gac ctc aat cgt gca aag gcc ctg tta aga acg gat gcg atc cga 835 Ala Asp Leu Asn Arg Ala Lys Ala Leu Leu Arg Thr Asp Ala Ile Arg 230 235 240 245 tgaatgctgc aaccaggcgt gcttctctgc 865 <210> 80 <211> 245 <212> PRT <213> Corynebacterium glutamicum <400> 80 Met Thr Arg Ser Asn Leu Pro Ala Trp Glu Gln Ala Asp Pro Ser Val 1 5 10 15 His Ala Ser Asp Pro Arg Ala Ile Thr Phe Ala Glu Asp Phe Gly Ile 20 25 30 Arg Pro Ile Pro Ala Val Gly Pro Ile Asp Thr Thr Ala Ile Cys Ala 35 40 45 Thr Pro Ser Asn Gly Phe Glu Gln Leu Trp Lys Ala Ile Glu Pro Glu 50 55 60 Thr Arg Thr Arg Ala Asn Asp Ile His Leu Pro Ile Val Val Ala Tyr 65 70 75 80 Ala Glu Arg Leu Cys Asp Ala Tyr Pro Leu Ala Asp Arg Glu Leu Val 85 90 95 Leu Val Ala Ala Ile Leu His Asp Thr Gly Trp Ala His Val Asp Glu 100 105 110 Ser Arg Ile Ile Ser Glu Gly Phe Ser Gly Asn Trp Arg Lys Ala Ala 115 120 125 Ile Arg Phe Glu His Glu Thr Glu Gly Cys Thr Val Ala Arg Arg Val 130 135 140 Leu Pro Ser Leu Gly Tyr Thr Val Asp Phe Val Glu His Val Cys Asp 145 150 155 160 Ile Ile Asp Gly His Asp Thr Arg Gln Val Ala Tyr Ser Leu Glu Asp 165 170 175 Ala Leu Val Arg Asp Cys Asp Arg Leu Trp Arg Phe Asp Arg Ala Gly 180 185 190 Ile Thr Ala Ser Ser Ser Trp Phe Gly Met Pro Val Ser Asp Tyr Val 195 200 205 Asp Arg Leu His Arg Glu Ile Leu Pro Glu Leu Ile Thr Glu Ala Ala 210 215 220 His Gln Met Ala Thr Ala Asp Leu Asn Arg Ala Lys Ala Leu Leu Arg 225 230 235 240 Thr Asp Ala Ile Arg 245 <210> 81 <211> 1201 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1171) <223> RXA00691 <400> 81 gaattatcat cgccatcttg gccatccttg ccgccatcgc tggtgtcatg ggaccaatga 60 tggctaacct gcagttttaa catctgagag aagtacagtg atg tct cga acc tca 115 Met Ser Arg Thr Ser 1 5 act ttt cac ctg tcg ctg aag tct ttt gca gct gca gtc gca cta tgg 163 Thr Phe His Leu Ser Leu Lys Ser Phe Ala Ala Ala Val Ala Leu Trp 10 15 20 att gtt ctt gcc ata tcg cca tgg gtt cct tct gcg cac gcc ttg acc 211 Ile Val Leu Ala Ile Ser Pro Trp Val Pro Ser Ala His Ala Leu Thr 25 30 35 acg cct tgt gaa gac gac caa gtg aca gtg atg gtt gag ggc aac acc 259 Thr Pro Cys Glu Asp Asp Gln Val Thr Val Met Val Glu Gly Asn Thr 40 45 50 atc ggc tgt gct gac gcc ggc gga aat ggc tat caa acg ctt ctt gat 307 Ile Gly Cys Ala Asp Ala Gly Gly Asn Gly Tyr Gln Thr Leu Leu Asp 55 60 65 gcc gga ttt gat gtg gaa acc acc gtt cag ttt cca gaa ttc ttg tgc 355 Ala Gly Phe Asp Val Glu Thr Thr Val Gln Phe Pro Glu Phe Leu Cys 70 75 80 85 cga atc aat gat ttc cca ggt cct gat gtg gac gat tgc atg acc gca 403 Arg Ile Asn Asp Phe Pro Gly Pro Asp Val Asp Asp Cys Met Thr Ala 90 95 100 tca cct gct gaa gct tat tgg tct tat tgg cat gct ccc ctc ggc gga 451 Ser Pro Ala Glu Ala Tyr Trp Ser Tyr Trp His Ala Pro Leu Gly Gly 105 110 115 gat gaa tgg gaa tac agc aac ctt gga gct ttc ctc tac tac ccc aaa 499 Asp Glu Trp Glu Tyr Ser Asn Leu Gly Ala Phe Leu Tyr Tyr Pro Lys 120 125 130 ccc ggc act gtt gaa gcg tgg tat tgg gga gat act gat cgt ccc ggc 547 Pro Gly Thr Val Glu Ala Trp Tyr Trp Gly Asp Thr Asp Arg Pro Gly 135 140 145 gcg atc ccg gtg agt aaa tct cag gcg gag ttg ggg tta gac tcc gcg 595 Ala Ile Pro Val Ser Lys Ser Gln Ala Glu Leu Gly Leu Asp Ser Ala 150 155 160 165 gat ccg gat tac aaa att gat ttt gat cca aat gat ttc atc acc aca 643 Asp Pro Asp Tyr Lys Ile Asp Phe Asp Pro Asn Asp Phe Ile Thr Thr 170 175 180 acc cca acc tcc gag tcc cct atc gcc gat tta ggg ggt gac gaa gag 691 Thr Pro Thr Ser Glu Ser Pro Ile Ala Asp Leu Gly Gly Asp Glu Glu 185 190 195 ccc act gaa act act gaa gct cct atc gca ggg gct gga gct ggt tcg 739 Pro Thr Glu Thr Thr Glu Ala Pro Ile Ala Gly Ala Gly Ala Gly Ser 200 205 210 gca aga gga caa gca gct gaa ccc act gct gag gta aac cct gag aac 787 Ala Arg Gly Gln Ala Ala Glu Pro Thr Ala Glu Val Asn Pro Glu Asn 215 220 225 cct aat gag gta ttg gtg tat cag gat tct gaa gga aac tcg att act 835 Pro Asn Glu Val Leu Val Tyr Gln Asp Ser Glu Gly Asn Ser Ile Thr 230 235 240 245 aaa ggt cag tac gag aac ttg gtt gct gca gca gcc gct aag acc act 883 Lys Gly Gln Tyr Glu Asn Leu Val Ala Ala Ala Ala Ala Lys Thr Thr 250 255 260 gct gct gtc caa gcc cca gct ggg gct ggt gaa gca aat agc caa ccg 931 Ala Ala Val Gln Ala Pro Ala Gly Ala Gly Glu Ala Asn Ser Gln Pro 265 270 275 cag gca aca gcg gtg gca gaa gct cct gaa gtt gat ccg atg acc acg 979 Gln Ala Thr Ala Val Ala Glu Ala Pro Glu Val Asp Pro Met Thr Thr 280 285 290 cag gtt ctt atg gcg cct gcg ggc caa gat gga gac gtc atg gct gag 1027 Gln Val Leu Met Ala Pro Ala Gly Gln Asp Gly Asp Val Met Ala Glu 295 300 305 ggt tcg acg cag cag acg tac gcc aca ggc acg gtg gat tct tct gct 1075 Gly Ser Thr Gln Gln Thr Tyr Ala Thr Gly Thr Val Asp Ser Ser Ala 310 315 320 325 cag gga tgg atc att gga ctc aca ctg gct gtc att tcc ttg gtt tca 1123 Gln Gly Trp Ile Ile Gly Leu Thr Leu Ala Val Ile Ser Leu Val Ser 330 335 340 gcg tct gct gtg gcg gcg tgg gcg att cgt cgt tca gag gtc cag ggt 1171 Ala Ser Ala Val Ala Ala Trp Ala Ile Arg Arg Ser Glu Val Gln Gly 345 350 355 taaagcttcg tgaaatggat tgagcgatat 1201 <210> 82 <211> 357 <212> PRT <213> Corynebacterium glutamicum <400> 82 Met Ser Arg Thr Ser Thr Phe His Leu Ser Leu Lys Ser Phe Ala Ala 1 5 10 15 Ala Val Ala Leu Trp Ile Val Leu Ala Ile Ser Pro Trp Val Pro Ser 20 25 30 Ala His Ala Leu Thr Thr Pro Cys Glu Asp Asp Gln Val Thr Val Met 35 40 45 Val Glu Gly Asn Thr Ile Gly Cys Ala Asp Ala Gly Gly Asn Gly Tyr 50 55 60 Gln Thr Leu Leu Asp Ala Gly Phe Asp Val Glu Thr Thr Val Gln Phe 65 70 75 80 Pro Glu Phe Leu Cys Arg Ile Asn Asp Phe Pro Gly Pro Asp Val Asp 85 90 95 Asp Cys Met Thr Ala Ser Pro Ala Glu Ala Tyr Trp Ser Tyr Trp His 100 105 110 Ala Pro Leu Gly Gly Asp Glu Trp Glu Tyr Ser Asn Leu Gly Ala Phe 115 120 125 Leu Tyr Tyr Pro Lys Pro Gly Thr Val Glu Ala Trp Tyr Trp Gly Asp 130 135 140 Thr Asp Arg Pro Gly Ala Ile Pro Val Ser Lys Ser Gln Ala Glu Leu 145 150 155 160 Gly Leu Asp Ser Ala Asp Pro Asp Tyr Lys Ile Asp Phe Asp Pro Asn 165 170 175 Asp Phe Ile Thr Thr Thr Pro Thr Ser Glu Ser Pro Ile Ala Asp Leu 180 185 190 Gly Gly Asp Glu Glu Pro Thr Glu Thr Thr Glu Ala Pro Ile Ala Gly 195 200 205 Ala Gly Ala Gly Ser Ala Arg Gly Gln Ala Ala Glu Pro Thr Ala Glu 210 215 220 Val Asn Pro Glu Asn Pro Asn Glu Val Leu Val Tyr Gln Asp Ser Glu 225 230 235 240 Gly Asn Ser Ile Thr Lys Gly Gln Tyr Glu Asn Leu Val Ala Ala Ala 245 250 255 Ala Ala Lys Thr Thr Ala Ala Val Gln Ala Pro Ala Gly Ala Gly Glu 260 265 270 Ala Asn Ser Gln Pro Gln Ala Thr Ala Val Ala Glu Ala Pro Glu Val 275 280 285 Asp Pro Met Thr Thr Gln Val Leu Met Ala Pro Ala Gly Gln Asp Gly 290 295 300 Asp Val Met Ala Glu Gly Ser Thr Gln Gln Thr Tyr Ala Thr Gly Thr 305 310 315 320 Val Asp Ser Ser Ala Gln Gly Trp Ile Ile Gly Leu Thr Leu Ala Val 325 330 335 Ile Ser Leu Val Ser Ala Ser Ala Val Ala Ala Trp Ala Ile Arg Arg 340 345 350 Ser Glu Val Gln Gly 355 <210> 83 <211> 1759 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1729) <223> RXA00719 <400> 83 cagatgatgc acacatcgtg gacacctctg atatgaccat ggatcaagta cttgatcacc 60 tcatccacct agtggaagcc tccgctgaaa ggagcaacca gtg act gat aaa cac 115 Val Thr Asp Lys His 1 5 acc atg cct ggt gaa gag gac gac acc gta ttc gtc tac cac acc cac 163 Thr Met Pro Gly Glu Glu Asp Asp Thr Val Phe Val Tyr His Thr His 10 15 20 aaa ggc gaa atg gac gtc gaa ggt gcg ttt gct gac gaa gaa gaa cta 211 Lys Gly Glu Met Asp Val Glu Gly Ala Phe Ala Asp Glu Glu Glu Leu 25 30 35 gca cca cac ggc ggt tgg gct tcc gca gat ttc gac cca gca gaa ttc 259 Ala Pro His Gly Gly Trp Ala Ser Ala Asp Phe Asp Pro Ala Glu Phe 40 45 50 ggc tac gaa gac tct gac gat gac ttc gat gca gag gac ttt gac gaa 307 Gly Tyr Glu Asp Ser Asp Asp Asp Phe Asp Ala Glu Asp Phe Asp Glu 55 60 65 aca gag ttc tcc aac cct gat ttc ggc gaa gac tac tct gat gaa gac 355 Thr Glu Phe Ser Asn Pro Asp Phe Gly Glu Asp Tyr Ser Asp Glu Asp 70 75 80 85 tgg gaa gaa atc gag acc gca ttc gga ttc gac cca agc cac ctt gaa 403 Trp Glu Glu Ile Glu Thr Ala Phe Gly Phe Asp Pro Ser His Leu Glu 90 95 100 gaa gct ctc tgc acg gtc gct atc gtc gga cgc cca aat gtt ggt aaa 451 Glu Ala Leu Cys Thr Val Ala Ile Val Gly Arg Pro Asn Val Gly Lys 105 110 115 tca acc ttg gtg aac cgc ttt att gga cgt cga gaa gca gtc gtg gaa 499 Ser Thr Leu Val Asn Arg Phe Ile Gly Arg Arg Glu Ala Val Val Glu 120 125 130 gat ttc ccc ggc gta acc cgt gac cgc atc tcc tac atc tct gac tgg 547 Asp Phe Pro Gly Val Thr Arg Asp Arg Ile Ser Tyr Ile Ser Asp Trp 135 140 145 ggt gga cac cgt ttc tgg gtt cag gac aca ggc gga tgg gat cct aac 595 Gly Gly His Arg Phe Trp Val Gln Asp Thr Gly Gly Trp Asp Pro Asn 150 155 160 165 gtc aag ggc atc cac gca tcg atc gca cag caa gca gaa gtt gct atg 643 Val Lys Gly Ile His Ala Ser Ile Ala Gln Gln Ala Glu Val Ala Met 170 175 180 agc act gcc gat gtc atc gta ttc gtc gtg gac acc aag gtg ggc atc 691 Ser Thr Ala Asp Val Ile Val Phe Val Val Asp Thr Lys Val Gly Ile 185 190 195 acc gaa act gac tca gtg atg gca gca aaa ctg ttg cgc tcg gaa gtg 739 Thr Glu Thr Asp Ser Val Met Ala Ala Lys Leu Leu Arg Ser Glu Val 200 205 210 cca gtg atc ttg gtt gcg aac aaa ttc gac tcc gac agc cag tgg gct 787 Pro Val Ile Leu Val Ala Asn Lys Phe Asp Ser Asp Ser Gln Trp Ala 215 220 225 gac atg gct gag ttc tac agc ctc ggc ctt ggc gat cca tac cca gtt 835 Asp Met Ala Glu Phe Tyr Ser Leu Gly Leu Gly Asp Pro Tyr Pro Val 230 235 240 245 tca gcc cag cat gga cgt ggt ggc gct gac gtt ttg gac aaa gtc ctt 883 Ser Ala Gln His Gly Arg Gly Gly Ala Asp Val Leu Asp Lys Val Leu 250 255 260 gaa ctc ttc cca gaa gag cct cgc tcc aag tcc atc gtg gaa ggc cct 931 Glu Leu Phe Pro Glu Glu Pro Arg Ser Lys Ser Ile Val Glu Gly Pro 265 270 275 cgt cgt gtc gcc ctt gtg ggt aag cca aac gtg ggt aag tct tca ctg 979 Arg Arg Val Ala Leu Val Gly Lys Pro Asn Val Gly Lys Ser Ser Leu 280 285 290 ctc aac aag ttt gct ggc gag acc cgc tct gtc gtg gac aat gtt gca 1027 Leu Asn Lys Phe Ala Gly Glu Thr Arg Ser Val Val Asp Asn Val Ala 295 300 305 gga acc acc gtt gac ccc gtt gac tcc ctg att cag ctg gat caa aaa 1075 Gly Thr Thr Val Asp Pro Val Asp Ser Leu Ile Gln Leu Asp Gln Lys 310 315 320 325 ctg tgg aaa ttc gtg gat act gct ggt ctt cgc aaa aag gtc aag act 1123 Leu Trp Lys Phe Val Asp Thr Ala Gly Leu Arg Lys Lys Val Lys Thr 330 335 340 gca tct ggc cac gag tac tac gca tca ctg cgt acc cac ggt gcc atc 1171 Ala Ser Gly His Glu Tyr Tyr Ala Ser Leu Arg Thr His Gly Ala Ile 345 350 355 gat gca gct gag ctg tgt gtt ttg ctt atc gat tcc tcc gaa ccc atc 1219 Asp Ala Ala Glu Leu Cys Val Leu Leu Ile Asp Ser Ser Glu Pro Ile 360 365 370 acc gag cag gat cag cgc gtg ctc gca atg atc acc gat gcc ggt aag 1267 Thr Glu Gln Asp Gln Arg Val Leu Ala Met Ile Thr Asp Ala Gly Lys 375 380 385 gca ctg gtt att gcg ttc aac aag tgg gat ctc atg gat gaa gat cgc 1315 Ala Leu Val Ile Ala Phe Asn Lys Trp Asp Leu Met Asp Glu Asp Arg 390 395 400 405 cgc atc gat ttg gat cgc gaa ctt gat ctc cag ttg gca cac gtg cct 1363 Arg Ile Asp Leu Asp Arg Glu Leu Asp Leu Gln Leu Ala His Val Pro 410 415 420 tgg gca aag cgc atc aac atc tcc gcc aaa acc ggt cgt gca ctg cag 1411 Trp Ala Lys Arg Ile Asn Ile Ser Ala Lys Thr Gly Arg Ala Leu Gln 425 430 435 cgc ctc gag cca gca atg ttg gaa gcg ctc gac aac tgg gat cgc cgt 1459 Arg Leu Glu Pro Ala Met Leu Glu Ala Leu Asp Asn Trp Asp Arg Arg 440 445 450 atc tcc act ggt cag ctg aac acc tgg ctg cgt gaa gca att gct gcg 1507 Ile Ser Thr Gly Gln Leu Asn Thr Trp Leu Arg Glu Ala Ile Ala Ala 455 460 465 aac cca cca cca atg cgt ggc gga cgt ttg cct cga gtg ctg ttt gcc 1555 Asn Pro Pro Pro Met Arg Gly Gly Arg Leu Pro Arg Val Leu Phe Ala 470 475 480 485 acc cag gca tct act cag cca cca gtg atc gta ctg ttc acc acc ggc 1603 Thr Gln Ala Ser Thr Gln Pro Pro Val Ile Val Leu Phe Thr Thr Gly 490 495 500 ttc ctc gaa gca ggt tac cga cga tac ctg gag cgc aag ttc cgt gaa 1651 Phe Leu Glu Ala Gly Tyr Arg Arg Tyr Leu Glu Arg Lys Phe Arg Glu 505 510 515 cgt ttc ggc ttt gaa ggc act cca gtg cga atc gct gtg cgt gtt cgc 1699 Arg Phe Gly Phe Glu Gly Thr Pro Val Arg Ile Ala Val Arg Val Arg 520 525 530 gag cgc cgc ggc aag ggc gga aac aag cag taaagcttga ttttccctaa 1749 Glu Arg Arg Gly Lys Gly Gly Asn Lys Gln 535 540 aagcacttat 1759 <210> 84 <211> 543 <212> PRT <213> Corynebacterium glutamicum <400> 84 Val Thr Asp Lys His Thr Met Pro Gly Glu Glu Asp Asp Thr Val Phe 1 5 10 15 Val Tyr His Thr His Lys Gly Glu Met Asp Val Glu Gly Ala Phe Ala 20 25 30 Asp Glu Glu Glu Leu Ala Pro His Gly Gly Trp Ala Ser Ala Asp Phe 35 40 45 Asp Pro Ala Glu Phe Gly Tyr Glu Asp Ser Asp Asp Asp Phe Asp Ala 50 55 60 Glu Asp Phe Asp Glu Thr Glu Phe Ser Asn Pro Asp Phe Gly Glu Asp 65 70 75 80 Tyr Ser Asp Glu Asp Trp Glu Glu Ile Glu Thr Ala Phe Gly Phe Asp 85 90 95 Pro Ser His Leu Glu Glu Ala Leu Cys Thr Val Ala Ile Val Gly Arg 100 105 110 Pro Asn Val Gly Lys Ser Thr Leu Val Asn Arg Phe Ile Gly Arg Arg 115 120 125 Glu Ala Val Val Glu Asp Phe Pro Gly Val Thr Arg Asp Arg Ile Ser 130 135 140 Tyr Ile Ser Asp Trp Gly Gly His Arg Phe Trp Val Gln Asp Thr Gly 145 150 155 160 Gly Trp Asp Pro Asn Val Lys Gly Ile His Ala Ser Ile Ala Gln Gln 165 170 175 Ala Glu Val Ala Met Ser Thr Ala Asp Val Ile Val Phe Val Val Asp 180 185 190 Thr Lys Val Gly Ile Thr Glu Thr Asp Ser Val Met Ala Ala Lys Leu 195 200 205 Leu Arg Ser Glu Val Pro Val Ile Leu Val Ala Asn Lys Phe Asp Ser 210 215 220 Asp Ser Gln Trp Ala Asp Met Ala Glu Phe Tyr Ser Leu Gly Leu Gly 225 230 235 240 Asp Pro Tyr Pro Val Ser Ala Gln His Gly Arg Gly Gly Ala Asp Val 245 250 255 Leu Asp Lys Val Leu Glu Leu Phe Pro Glu Glu Pro Arg Ser Lys Ser 260 265 270 Ile Val Glu Gly Pro Arg Arg Val Ala Leu Val Gly Lys Pro Asn Val 275 280 285 Gly Lys Ser Ser Leu Leu Asn Lys Phe Ala Gly Glu Thr Arg Ser Val 290 295 300 Val Asp Asn Val Ala Gly Thr Thr Val Asp Pro Val Asp Ser Leu Ile 305 310 315 320 Gln Leu Asp Gln Lys Leu Trp Lys Phe Val Asp Thr Ala Gly Leu Arg 325 330 335 Lys Lys Val Lys Thr Ala Ser Gly His Glu Tyr Tyr Ala Ser Leu Arg 340 345 350 Thr His Gly Ala Ile Asp Ala Ala Glu Leu Cys Val Leu Leu Ile Asp 355 360 365 Ser Ser Glu Pro Ile Thr Glu Gln Asp Gln Arg Val Leu Ala Met Ile 370 375 380 Thr Asp Ala Gly Lys Ala Leu Val Ile Ala Phe Asn Lys Trp Asp Leu 385 390 395 400 Met Asp Glu Asp Arg Arg Ile Asp Leu Asp Arg Glu Leu Asp Leu Gln 405 410 415 Leu Ala His Val Pro Trp Ala Lys Arg Ile Asn Ile Ser Ala Lys Thr 420 425 430 Gly Arg Ala Leu Gln Arg Leu Glu Pro Ala Met Leu Glu Ala Leu Asp 435 440 445 Asn Trp Asp Arg Arg Ile Ser Thr Gly Gln Leu Asn Thr Trp Leu Arg 450 455 460 Glu Ala Ile Ala Ala Asn Pro Pro Pro Met Arg Gly Gly Arg Leu Pro 465 470 475 480 Arg Val Leu Phe Ala Thr Gln Ala Ser Thr Gln Pro Pro Val Ile Val 485 490 495 Leu Phe Thr Thr Gly Phe Leu Glu Ala Gly Tyr Arg Arg Tyr Leu Glu 500 505 510 Arg Lys Phe Arg Glu Arg Phe Gly Phe Glu Gly Thr Pro Val Arg Ile 515 520 525 Ala Val Arg Val Arg Glu Arg Arg Gly Lys Gly Gly Asn Lys Gln 530 535 540 <210> 85 <211> 2626 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2596) <223> RXA00731 <400> 85 ttgataccgt ggccggtgga cattccttcc aggtgtggcg cgtggcttta gcgaatactt 60 ttgattgggt tgccaagcgc ggcggattgc aggtttaaca atg aaa gac gct tca 115 Met Lys Asp Ala Ser 1 5 cag tcc tac tta tta ttc ggt ctg aga tgg ctg ggc agg tcc ctg cgt 163 Gln Ser Tyr Leu Leu Phe Gly Leu Arg Trp Leu Gly Arg Ser Leu Arg 10 15 20 ttc gca ccg tta agc ctg ctc atg atc gtt gtc atg cgg ggt ttg agg 211 Phe Ala Pro Leu Ser Leu Leu Met Ile Val Val Met Arg Gly Leu Arg 25 30 35 gaa gtg ttt ggc gcc gaa gat ccc gca aat agc tct ttg gta gac aac 259 Glu Val Phe Gly Ala Glu Asp Pro Ala Asn Ser Ser Leu Val Asp Asn 40 45 50 ctt ggg ctc acc ctg ccg tgg tct ctt aat gat ccg cat ttt ctc acc 307 Leu Gly Leu Thr Leu Pro Trp Ser Leu Asn Asp Pro His Phe Leu Thr 55 60 65 gca ggg ttt agc gct tcc acc acc aca gca gcg ctc atg tcc acg ttg 355 Ala Gly Phe Ser Ala Ser Thr Thr Thr Ala Ala Leu Met Ser Thr Leu 70 75 80 85 tgg atc atc gtg ttt gcg gtg ccc tct gaa cgg att ctg ggc agc ctc 403 Trp Ile Ile Val Phe Ala Val Pro Ser Glu Arg Ile Leu Gly Ser Leu 90 95 100 aaa ttc gcg atc aca gca gcg ctt atc cac atc act tcc att ccg ctg 451 Lys Phe Ala Ile Thr Ala Ala Leu Ile His Ile Thr Ser Ile Pro Leu 105 110 115 ggc atc ggc atc gcc cac ctc atc gaa gaa gcc gat ctc aac cgc tgg 499 Gly Ile Gly Ile Ala His Leu Ile Glu Glu Ala Asp Leu Asn Arg Trp 120 125 130 ggc aac aac atg ttg gcc gat gtg ctg ctc acc cca gat ttc tgg gtc 547 Gly Asn Asn Met Leu Ala Asp Val Leu Leu Thr Pro Asp Phe Trp Val 135 140 145 ttc ggc gtc gcc gct ttc gca tcc gcc tcc atg cca ctg ctc tgg cga 595 Phe Gly Val Ala Ala Phe Ala Ser Ala Ser Met Pro Leu Leu Trp Arg 150 155 160 165 cgg cgc acc cga ttg ttc ctc ttt act atc acc ttg acg ctg ctg ctt 643 Arg Arg Thr Arg Leu Phe Leu Phe Thr Ile Thr Leu Thr Leu Leu Leu 170 175 180 tat acg ggc acg ctt gcc gac gtc acc atg ctc acc gcg acc atc atc 691 Tyr Thr Gly Thr Leu Ala Asp Val Thr Met Leu Thr Ala Thr Ile Ile 185 190 195 ggc acc gtt gcc ggc gag ttg aac agg cat cgg aaa acc cca ggt ggc 739 Gly Thr Val Ala Gly Glu Leu Asn Arg His Arg Lys Thr Pro Gly Gly 200 205 210 cgc tgg ctt ccc ggt tcc ctc acc gtg cgt gaa gcg cgc att atg acg 787 Arg Trp Leu Pro Gly Ser Leu Thr Val Arg Glu Ala Arg Ile Met Thr 215 220 225 gcc att ttg gtc act gcc gta gca gca ggt cca gtg ctt gct gcg ctt 835 Ala Ile Leu Val Thr Ala Val Ala Ala Gly Pro Val Leu Ala Ala Leu 230 235 240 245 aat cca ctc acc cac ggc cct ttt tcc agt gca acg aaa ttg atc tgg 883 Asn Pro Leu Thr His Gly Pro Phe Ser Ser Ala Thr Lys Leu Ile Trp 250 255 260 cag ccc ctt gtc act gaa gaa cac atg cat cac ctc tgc cac aca gac 931 Gln Pro Leu Val Thr Glu Glu His Met His His Leu Cys His Thr Asp 265 270 275 agc acc tct gat gca tgc caa ggt gcg ctt gat cag ctc caa cag cac 979 Ser Thr Ser Asp Ala Cys Gln Gly Ala Leu Asp Gln Leu Gln Gln His 280 285 290 ggt gtt ggc cct tcc gtt gcc aac ctg att cca ctg atc ctc acc gtg 1027 Gly Val Gly Pro Ser Val Ala Asn Leu Ile Pro Leu Ile Leu Thr Val 295 300 305 gtc ctt gcg atg ggg ctt agc cgc gga cgt cga ctt gca tgg att ttg 1075 Val Leu Ala Met Gly Leu Ser Arg Gly Arg Arg Leu Ala Trp Ile Leu 310 315 320 325 gcg gtt ttg gcc cag ctc att tcc atc gca gtg ttg atg ttc cag ctg 1123 Ala Val Leu Ala Gln Leu Ile Ser Ile Ala Val Leu Met Phe Gln Leu 330 335 340 acc aaa cta tcg gct gat tcc acc gat ctt cta tgg tca gtc aat gcc 1171 Thr Lys Leu Ser Ala Asp Ser Thr Asp Leu Leu Trp Ser Val Asn Ala 345 350 355 ttt agc gtg atc gtt cct tgg ctg gtg gcg ctc gcc gtc ttg gtg ttt 1219 Phe Ser Val Ile Val Pro Trp Leu Val Ala Leu Ala Val Leu Val Phe 360 365 370 tcc cgc cgt gca ttc cag gtg aag att gat acc acc cgg att tct aaa 1267 Ser Arg Arg Ala Phe Gln Val Lys Ile Asp Thr Thr Arg Ile Ser Lys 375 380 385 tcc tta ggc gct ctc atg gtt aca tgg ttg gca acg gca gca ttg tgg 1315 Ser Leu Gly Ala Leu Met Val Thr Trp Leu Ala Thr Ala Ala Leu Trp 390 395 400 405 atc ctt gcc aca ttg ttc ctg cca cac gca ttc cac cca cat cca aca 1363 Ile Leu Ala Thr Leu Phe Leu Pro His Ala Phe His Pro His Pro Thr 410 415 420 ttg ggg ctg gct ttc aaa gaa ctc ccc ttc cgc tat ctc cca cca act 1411 Leu Gly Leu Ala Phe Lys Glu Leu Pro Phe Arg Tyr Leu Pro Pro Thr 425 430 435 atc gaa acg gtg tta agc cat caa ctc ttc ccc aga agc cct gct ggg 1459 Ile Glu Thr Val Leu Ser His Gln Leu Phe Pro Arg Ser Pro Ala Gly 440 445 450 tgg gca gtg ttt gaa tgg act gga acg cta ttc tgg ctg gtc gta gca 1507 Trp Ala Val Phe Glu Trp Thr Gly Thr Leu Phe Trp Leu Val Val Ala 455 460 465 gca act ctt tat cat ctg ctc atg ggt gtg ccc agc aac aaa gcg cac 1555 Ala Thr Leu Tyr His Leu Leu Met Gly Val Pro Ser Asn Lys Ala His 470 475 480 485 gag gac caa gaa aac gca gcg act ctc ctg cgc tct ggc agc ggc gat 1603 Glu Asp Gln Glu Asn Ala Ala Thr Leu Leu Arg Ser Gly Ser Gly Asp 490 495 500 cac ttg tcc tgg atg acc att tgg ggt ggc aat acg tat tgg tgg gca 1651 His Leu Ser Trp Met Thr Ile Trp Gly Gly Asn Thr Tyr Trp Trp Ala 505 510 515 cca gaa aat gca gga tat gtg gcc tac cgc gtg aaa agg ggc atc gca 1699 Pro Glu Asn Ala Gly Tyr Val Ala Tyr Arg Val Lys Arg Gly Ile Ala 520 525 530 att aca ttg ggt gag cct att ctg ggt ccg gat tca tcc gtc tct aaa 1747 Ile Thr Leu Gly Glu Pro Ile Leu Gly Pro Asp Ser Ser Val Ser Lys 535 540 545 gca gag ctg gcc gca cag ttt gaa gaa ttt gcc agc aac caa ggc tgg 1795 Ala Glu Leu Ala Ala Gln Phe Glu Glu Phe Ala Ser Asn Gln Gly Trp 550 555 560 565 att gtt gcg tgg tat tcc gtt tgt gaa gaa ttc tca aag gaa cgc atc 1843 Ile Val Ala Trp Tyr Ser Val Cys Glu Glu Phe Ser Lys Glu Arg Ile 570 575 580 aac gct ggc cac cac aca ctt cgt gtg gct gag gaa gca gtc tta agc 1891 Asn Ala Gly His His Thr Leu Arg Val Ala Glu Glu Ala Val Leu Ser 585 590 595 tca gct aat gcg gat ttc aaa ggt aag cac ttc caa aat gtc cgc acc 1939 Ser Ala Asn Ala Asp Phe Lys Gly Lys His Phe Gln Asn Val Arg Thr 600 605 610 gcc cga aac cgc gcg gcc aaa gag ggc gta agt tcc atc tgg aca acc 1987 Ala Arg Asn Arg Ala Ala Lys Glu Gly Val Ser Ser Ile Trp Thr Thr 615 620 625 tgg gct gat ttg agt gcc gaa atg cag cac aag atc atc acg ctg tcg 2035 Trp Ala Asp Leu Ser Ala Glu Met Gln His Lys Ile Ile Thr Leu Ser 630 635 640 645 gaa gaa tgg gtc tct gat aaa gct ctg ccg gag atg ggc ttc acg ctt 2083 Glu Glu Trp Val Ser Asp Lys Ala Leu Pro Glu Met Gly Phe Thr Leu 650 655 660 ggc act gtc aac gag ctc tca gat cca gat acc tat ctt ctt ctc gcg 2131 Gly Thr Val Asn Glu Leu Ser Asp Pro Asp Thr Tyr Leu Leu Leu Ala 665 670 675 att gat gag gaa gag cat ctg cac ggt gtg acc agt tgg ttg ccg gtc 2179 Ile Asp Glu Glu Glu His Leu His Gly Val Thr Ser Trp Leu Pro Val 680 685 690 tat gaa aaa gga cgc atc gtc ggc tac aca ctt gat gtg atg cgc cgt 2227 Tyr Glu Lys Gly Arg Ile Val Gly Tyr Thr Leu Asp Val Met Arg Arg 695 700 705 gat ccg caa ggc ttt aaa tct gtc atc gag ttt ctc att tcc gag gcc 2275 Asp Pro Gln Gly Phe Lys Ser Val Ile Glu Phe Leu Ile Ser Glu Ala 710 715 720 725 gtc gtt atc gca agg gat cac gat ctg gaa tgg atg tcg atg tcc ggc 2323 Val Val Ile Ala Arg Asp His Asp Leu Glu Trp Met Ser Met Ser Gly 730 735 740 gct cct ttg agt acg ccc cca ggt gtg gcc gac gac ggc acc atc gga 2371 Ala Pro Leu Ser Thr Pro Pro Gly Val Ala Asp Asp Gly Thr Ile Gly 745 750 755 caa att ttg gag ctt ttg ggc cga gca atg gag ccg ttc tac ggt ttc 2419 Gln Ile Leu Glu Leu Leu Gly Arg Ala Met Glu Pro Phe Tyr Gly Phe 760 765 770 cgt tcc ctc gct gcg tcc aag aac aaa ttc cac cca gaa cac cac ggt 2467 Arg Ser Leu Ala Ala Ser Lys Asn Lys Phe His Pro Glu His His Gly 775 780 785 tgg tac ttg tgt tac cgc gat gaa tta tcg tta cca agc att ggc ctt 2515 Trp Tyr Leu Cys Tyr Arg Asp Glu Leu Ser Leu Pro Ser Ile Gly Leu 790 795 800 805 gcc gtt gct gcc tgc tac ctc aac gag ttt ccg ctg ccg aat tgg ctg 2563 Ala Val Ala Ala Cys Tyr Leu Asn Glu Phe Pro Leu Pro Asn Trp Leu 810 815 820 aaa aag acc gcc act tcc gcc cca agc cac agc tagaaaaacg cgtaaccttg 2616 Lys Lys Thr Ala Thr Ser Ala Pro Ser His Ser 825 830 gtgagaaacc 2626 <210> 86 <211> 832 <212> PRT <213> Corynebacterium glutamicum <400> 86 Met Lys Asp Ala Ser Gln Ser Tyr Leu Leu Phe Gly Leu Arg Trp Leu 1 5 10 15 Gly Arg Ser Leu Arg Phe Ala Pro Leu Ser Leu Leu Met Ile Val Val 20 25 30 Met Arg Gly Leu Arg Glu Val Phe Gly Ala Glu Asp Pro Ala Asn Ser 35 40 45 Ser Leu Val Asp Asn Leu Gly Leu Thr Leu Pro Trp Ser Leu Asn Asp 50 55 60 Pro His Phe Leu Thr Ala Gly Phe Ser Ala Ser Thr Thr Thr Ala Ala 65 70 75 80 Leu Met Ser Thr Leu Trp Ile Ile Val Phe Ala Val Pro Ser Glu Arg 85 90 95 Ile Leu Gly Ser Leu Lys Phe Ala Ile Thr Ala Ala Leu Ile His Ile 100 105 110 Thr Ser Ile Pro Leu Gly Ile Gly Ile Ala His Leu Ile Glu Glu Ala 115 120 125 Asp Leu Asn Arg Trp Gly Asn Asn Met Leu Ala Asp Val Leu Leu Thr 130 135 140 Pro Asp Phe Trp Val Phe Gly Val Ala Ala Phe Ala Ser Ala Ser Met 145 150 155 160 Pro Leu Leu Trp Arg Arg Arg Thr Arg Leu Phe Leu Phe Thr Ile Thr 165 170 175 Leu Thr Leu Leu Leu Tyr Thr Gly Thr Leu Ala Asp Val Thr Met Leu 180 185 190 Thr Ala Thr Ile Ile Gly Thr Val Ala Gly Glu Leu Asn Arg His Arg 195 200 205 Lys Thr Pro Gly Gly Arg Trp Leu Pro Gly Ser Leu Thr Val Arg Glu 210 215 220 Ala Arg Ile Met Thr Ala Ile Leu Val Thr Ala Val Ala Ala Gly Pro 225 230 235 240 Val Leu Ala Ala Leu Asn Pro Leu Thr His Gly Pro Phe Ser Ser Ala 245 250 255 Thr Lys Leu Ile Trp Gln Pro Leu Val Thr Glu Glu His Met His His 260 265 270 Leu Cys His Thr Asp Ser Thr Ser Asp Ala Cys Gln Gly Ala Leu Asp 275 280 285 Gln Leu Gln Gln His Gly Val Gly Pro Ser Val Ala Asn Leu Ile Pro 290 295 300 Leu Ile Leu Thr Val Val Leu Ala Met Gly Leu Ser Arg Gly Arg Arg 305 310 315 320 Leu Ala Trp Ile Leu Ala Val Leu Ala Gln Leu Ile Ser Ile Ala Val 325 330 335 Leu Met Phe Gln Leu Thr Lys Leu Ser Ala Asp Ser Thr Asp Leu Leu 340 345 350 Trp Ser Val Asn Ala Phe Ser Val Ile Val Pro Trp Leu Val Ala Leu 355 360 365 Ala Val Leu Val Phe Ser Arg Arg Ala Phe Gln Val Lys Ile Asp Thr 370 375 380 Thr Arg Ile Ser Lys Ser Leu Gly Ala Leu Met Val Thr Trp Leu Ala 385 390 395 400 Thr Ala Ala Leu Trp Ile Leu Ala Thr Leu Phe Leu Pro His Ala Phe 405 410 415 His Pro His Pro Thr Leu Gly Leu Ala Phe Lys Glu Leu Pro Phe Arg 420 425 430 Tyr Leu Pro Pro Thr Ile Glu Thr Val Leu Ser His Gln Leu Phe Pro 435 440 445 Arg Ser Pro Ala Gly Trp Ala Val Phe Glu Trp Thr Gly Thr Leu Phe 450 455 460 Trp Leu Val Val Ala Ala Thr Leu Tyr His Leu Leu Met Gly Val Pro 465 470 475 480 Ser Asn Lys Ala His Glu Asp Gln Glu Asn Ala Ala Thr Leu Leu Arg 485 490 495 Ser Gly Ser Gly Asp His Leu Ser Trp Met Thr Ile Trp Gly Gly Asn 500 505 510 Thr Tyr Trp Trp Ala Pro Glu Asn Ala Gly Tyr Val Ala Tyr Arg Val 515 520 525 Lys Arg Gly Ile Ala Ile Thr Leu Gly Glu Pro Ile Leu Gly Pro Asp 530 535 540 Ser Ser Val Ser Lys Ala Glu Leu Ala Ala Gln Phe Glu Glu Phe Ala 545 550 555 560 Ser Asn Gln Gly Trp Ile Val Ala Trp Tyr Ser Val Cys Glu Glu Phe 565 570 575 Ser Lys Glu Arg Ile Asn Ala Gly His His Thr Leu Arg Val Ala Glu 580 585 590 Glu Ala Val Leu Ser Ser Ala Asn Ala Asp Phe Lys Gly Lys His Phe 595 600 605 Gln Asn Val Arg Thr Ala Arg Asn Arg Ala Ala Lys Glu Gly Val Ser 610 615 620 Ser Ile Trp Thr Thr Trp Ala Asp Leu Ser Ala Glu Met Gln His Lys 625 630 635 640 Ile Ile Thr Leu Ser Glu Glu Trp Val Ser Asp Lys Ala Leu Pro Glu 645 650 655 Met Gly Phe Thr Leu Gly Thr Val Asn Glu Leu Ser Asp Pro Asp Thr 660 665 670 Tyr Leu Leu Leu Ala Ile Asp Glu Glu Glu His Leu His Gly Val Thr 675 680 685 Ser Trp Leu Pro Val Tyr Glu Lys Gly Arg Ile Val Gly Tyr Thr Leu 690 695 700 Asp Val Met Arg Arg Asp Pro Gln Gly Phe Lys Ser Val Ile Glu Phe 705 710 715 720 Leu Ile Ser Glu Ala Val Val Ile Ala Arg Asp His Asp Leu Glu Trp 725 730 735 Met Ser Met Ser Gly Ala Pro Leu Ser Thr Pro Pro Gly Val Ala Asp 740 745 750 Asp Gly Thr Ile Gly Gln Ile Leu Glu Leu Leu Gly Arg Ala Met Glu 755 760 765 Pro Phe Tyr Gly Phe Arg Ser Leu Ala Ala Ser Lys Asn Lys Phe His 770 775 780 Pro Glu His His Gly Trp Tyr Leu Cys Tyr Arg Asp Glu Leu Ser Leu 785 790 795 800 Pro Ser Ile Gly Leu Ala Val Ala Ala Cys Tyr Leu Asn Glu Phe Pro 805 810 815 Leu Pro Asn Trp Leu Lys Lys Thr Ala Thr Ser Ala Pro Ser His Ser 820 825 830 <210> 87 <211> 709 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(679) <223> RXA00740 <400> 87 gttataaata ttaaagtacg ctaaccatgg gtgcaggggg agacttctac agcagtcatg 60 gtccacacca cgactgctgt atatattaag gacgtaactc atg ttg aag aat aaa 115 Met Leu Lys Asn Lys 1 5 act ctt gcg ctg ctg gct gtc agt acg ctg atg ttt ggc tta tct gct 163 Thr Leu Ala Leu Leu Ala Val Ser Thr Leu Met Phe Gly Leu Ser Ala 10 15 20 tgc tct agt gat gct gac ggc ccg gac agt agc ggt gct agt agt agc 211 Cys Ser Ser Asp Ala Asp Gly Pro Asp Ser Ser Gly Ala Ser Ser Ser 25 30 35 agt act ggc tca tct tct gca tcg gct gac aca aca gat tct gca gct 259 Ser Thr Gly Ser Ser Ser Ala Ser Ala Asp Thr Thr Asp Ser Ala Ala 40 45 50 gtt gat aag gat gct caa tta gac acc ttt atg cgt tct gct gtg gct 307 Val Asp Lys Asp Ala Gln Leu Asp Thr Phe Met Arg Ser Ala Val Ala 55 60 65 gat gga tca tct gct gct gtg gct gtg gac aac gct gta ggt aag ggc 355 Asp Gly Ser Ser Ala Ala Val Ala Val Asp Asn Ala Val Gly Lys Gly 70 75 80 85 ttt gat aaa gct gat gcg cag gcg gct gcg gag cgc ttg ggt gat ggt 403 Phe Asp Lys Ala Asp Ala Gln Ala Ala Ala Glu Arg Leu Gly Asp Gly 90 95 100 ttc caa ttc gct gcg gat tac cag gct gtt ggc tat ttg gaa tct tgg 451 Phe Gln Phe Ala Ala Asp Tyr Gln Ala Val Gly Tyr Leu Glu Ser Trp 105 110 115 tac ttt ggt ggc gcg cga agc gag aag ctt gac gag gtg cgt agt gat 499 Tyr Phe Gly Gly Ala Arg Ser Glu Lys Leu Asp Glu Val Arg Ser Asp 120 125 130 gtc atc gct cat ttg tct gaa ttg gga ttt aca gat tta gag gct gaa 547 Val Ile Ala His Leu Ser Glu Leu Gly Phe Thr Asp Leu Glu Ala Glu 135 140 145 tcc tcg gca tct cgt att aca tta ggt gat tac tgt gat ggg gtc cct 595 Ser Ser Ala Ser Arg Ile Thr Leu Gly Asp Tyr Cys Asp Gly Val Pro 150 155 160 165 gag tat tgt gag ttg ttt ttt gat ggc gaa tct cct gac ttg tat gac 643 Glu Tyr Cys Glu Leu Phe Phe Asp Gly Glu Ser Pro Asp Leu Tyr Asp 170 175 180 atg ggt acg gag ctt gac tcg tat aag ccc act gaa taaagctatt 689 Met Gly Thr Glu Leu Asp Ser Tyr Lys Pro Thr Glu 185 190 tcacttaaag caccccgctt 709 <210> 88 <211> 193 <212> PRT <213> Corynebacterium glutamicum <400> 88 Met Leu Lys Asn Lys Thr Leu Ala Leu Leu Ala Val Ser Thr Leu Met 1 5 10 15 Phe Gly Leu Ser Ala Cys Ser Ser Asp Ala Asp Gly Pro Asp Ser Ser 20 25 30 Gly Ala Ser Ser Ser Ser Thr Gly Ser Ser Ser Ala Ser Ala Asp Thr 35 40 45 Thr Asp Ser Ala Ala Val Asp Lys Asp Ala Gln Leu Asp Thr Phe Met 50 55 60 Arg Ser Ala Val Ala Asp Gly Ser Ser Ala Ala Val Ala Val Asp Asn 65 70 75 80 Ala Val Gly Lys Gly Phe Asp Lys Ala Asp Ala Gln Ala Ala Ala Glu 85 90 95 Arg Leu Gly Asp Gly Phe Gln Phe Ala Ala Asp Tyr Gln Ala Val Gly 100 105 110 Tyr Leu Glu Ser Trp Tyr Phe Gly Gly Ala Arg Ser Glu Lys Leu Asp 115 120 125 Glu Val Arg Ser Asp Val Ile Ala His Leu Ser Glu Leu Gly Phe Thr 130 135 140 Asp Leu Glu Ala Glu Ser Ser Ala Ser Arg Ile Thr Leu Gly Asp Tyr 145 150 155 160 Cys Asp Gly Val Pro Glu Tyr Cys Glu Leu Phe Phe Asp Gly Glu Ser 165 170 175 Pro Asp Leu Tyr Asp Met Gly Thr Glu Leu Asp Ser Tyr Lys Pro Thr 180 185 190 Glu <210> 89 <211> 1225 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1195) <223> RXA00812 <400> 89 gattttctgt gcctctgcat tcgaaagtga aaattattca caggtgagcg tatcgcgggc 60 ggttgagagg tgagttatcc acaggccgca gagggggtcg ttg aaa gca cgt aag 115 Leu Lys Ala Arg Lys 1 5 cct cag gcc aca gta ggt gcc atg aac acc atc aca cac caa gca att 163 Pro Gln Ala Thr Val Gly Ala Met Asn Thr Ile Thr His Gln Ala Ile 10 15 20 ctc atc gca gtg gaa gat ccg gtc ctg cac cca gag gcc atg cac gta 211 Leu Ile Ala Val Glu Asp Pro Val Leu His Pro Glu Ala Met His Val 25 30 35 gct gca gcc act ggt cgg ccg gtt att gaa aca aca aat ttg atg gac 259 Ala Ala Ala Thr Gly Arg Pro Val Ile Glu Thr Thr Asn Leu Met Asp 40 45 50 atc tcc agg cat ttt cac cgc aca tcg gca gtg ctc att gat gcg tcg 307 Ile Ser Arg His Phe His Arg Thr Ser Ala Val Leu Ile Asp Ala Ser 55 60 65 atg gcc tct caa tta tca cct ggg aaa cgc cgc gac agg gtg ttt ctt 355 Met Ala Ser Gln Leu Ser Pro Gly Lys Arg Arg Asp Arg Val Phe Leu 70 75 80 85 ctc gat tct gat cca ggg ccc tct gat tgg aaa acg gcg atg aaa atc 403 Leu Asp Ser Asp Pro Gly Pro Ser Asp Trp Lys Thr Ala Met Lys Ile 90 95 100 cac gct gag caa gcc atg ttg ctt ccc gct cag gca ggg gag ttg ctc 451 His Ala Glu Gln Ala Met Leu Leu Pro Ala Gln Ala Gly Glu Leu Leu 105 110 115 agc gct tta ggc aga gat gac aaa caa ctg ccg gtg gct tcg ggc cat 499 Ser Ala Leu Gly Arg Asp Asp Lys Gln Leu Pro Val Ala Ser Gly His 120 125 130 gtc atc ggt gtt gcc ggg gtg gtg gga gga aca ggc gcg agc acg ttt 547 Val Ile Gly Val Ala Gly Val Val Gly Gly Thr Gly Ala Ser Thr Phe 135 140 145 gct gcg gcg ctc gca aag cgg cgt gcg gag tca gtc acc act gtg ctt 595 Ala Ala Ala Leu Ala Lys Arg Arg Ala Glu Ser Val Thr Thr Val Leu 150 155 160 165 atc gac gcc gac cct tcc tct ggc ggc atc gac ctg ttg cta gga atc 643 Ile Asp Ala Asp Pro Ser Ser Gly Gly Ile Asp Leu Leu Leu Gly Ile 170 175 180 gaa gat gtg ccc ggc gcg cgg tgg cct gat gtg ggg ttg cgt cgc gga 691 Glu Asp Val Pro Gly Ala Arg Trp Pro Asp Val Gly Leu Arg Arg Gly 185 190 195 act gtc cag gct gct gat gtg ttg aaa gcg ctg ccg agc act cct gat 739 Thr Val Gln Ala Ala Asp Val Leu Lys Ala Leu Pro Ser Thr Pro Asp 200 205 210 gag gtc gtg gtg ttg tct acg gcg cgg tct aat att ctg gat cct ttt 787 Glu Val Val Val Leu Ser Thr Ala Arg Ser Asn Ile Leu Asp Pro Phe 215 220 225 gca tta tcc gag tct gat gtt tcg gcg gcg att gat tgt ttc tta agc 835 Ala Leu Ser Glu Ser Asp Val Ser Ala Ala Ile Asp Cys Phe Leu Ser 230 235 240 245 gcc gat agg tcg gtg gat gtg gtg gtg gat ctg cct cat gcg aga gtg 883 Ala Asp Arg Ser Val Asp Val Val Val Asp Leu Pro His Ala Arg Val 250 255 260 cat cca gat att gcg gag cgc tta tcc cac ctg gtg tta gtc atc cct 931 His Pro Asp Ile Ala Glu Arg Leu Ser His Leu Val Leu Val Ile Pro 265 270 275 gca gag gtc cga gcg gtg gct gct gcc agg gct cgg tgt ctg gaa tta 979 Ala Glu Val Arg Ala Val Ala Ala Ala Arg Ala Arg Cys Leu Glu Leu 280 285 290 caa caa ttg cat gta tcc atc acg tgc gtg ttg agg cat cgc ggg tgg 1027 Gln Gln Leu His Val Ser Ile Thr Cys Val Leu Arg His Arg Gly Trp 295 300 305 tca ggt ttg gat gtt gca gaa gtg gaa gag att tta ggt gcg gat att 1075 Ser Gly Leu Asp Val Ala Glu Val Glu Glu Ile Leu Gly Ala Asp Ile 310 315 320 325 acc gcg gag gtt ggc tcg atc cag cgg ctg gct aag tcc gtg gag atg 1123 Thr Ala Glu Val Gly Ser Ile Gln Arg Leu Ala Lys Ser Val Glu Met 330 335 340 cat ggg ctg acc ggt tct ttg ccg agg gtt tta agc tca gca tgc gac 1171 His Gly Leu Thr Gly Ser Leu Pro Arg Val Leu Ser Ser Ala Cys Asp 345 350 355 gcg gtc ctc ggg gag gtg gcg gca tgactgacat tgatctggtg gtggaaaacg 1225 Ala Val Leu Gly Glu Val Ala Ala 360 365 <210> 90 <211> 365 <212> PRT <213> Corynebacterium glutamicum <400> 90 Leu Lys Ala Arg Lys Pro Gln Ala Thr Val Gly Ala Met Asn Thr Ile 1 5 10 15 Thr His Gln Ala Ile Leu Ile Ala Val Glu Asp Pro Val Leu His Pro 20 25 30 Glu Ala Met His Val Ala Ala Ala Thr Gly Arg Pro Val Ile Glu Thr 35 40 45 Thr Asn Leu Met Asp Ile Ser Arg His Phe His Arg Thr Ser Ala Val 50 55 60 Leu Ile Asp Ala Ser Met Ala Ser Gln Leu Ser Pro Gly Lys Arg Arg 65 70 75 80 Asp Arg Val Phe Leu Leu Asp Ser Asp Pro Gly Pro Ser Asp Trp Lys 85 90 95 Thr Ala Met Lys Ile His Ala Glu Gln Ala Met Leu Leu Pro Ala Gln 100 105 110 Ala Gly Glu Leu Leu Ser Ala Leu Gly Arg Asp Asp Lys Gln Leu Pro 115 120 125 Val Ala Ser Gly His Val Ile Gly Val Ala Gly Val Val Gly Gly Thr 130 135 140 Gly Ala Ser Thr Phe Ala Ala Ala Leu Ala Lys Arg Arg Ala Glu Ser 145 150 155 160 Val Thr Thr Val Leu Ile Asp Ala Asp Pro Ser Ser Gly Gly Ile Asp 165 170 175 Leu Leu Leu Gly Ile Glu Asp Val Pro Gly Ala Arg Trp Pro Asp Val 180 185 190 Gly Leu Arg Arg Gly Thr Val Gln Ala Ala Asp Val Leu Lys Ala Leu 195 200 205 Pro Ser Thr Pro Asp Glu Val Val Val Leu Ser Thr Ala Arg Ser Asn 210 215 220 Ile Leu Asp Pro Phe Ala Leu Ser Glu Ser Asp Val Ser Ala Ala Ile 225 230 235 240 Asp Cys Phe Leu Ser Ala Asp Arg Ser Val Asp Val Val Val Asp Leu 245 250 255 Pro His Ala Arg Val His Pro Asp Ile Ala Glu Arg Leu Ser His Leu 260 265 270 Val Leu Val Ile Pro Ala Glu Val Arg Ala Val Ala Ala Ala Arg Ala 275 280 285 Arg Cys Leu Glu Leu Gln Gln Leu His Val Ser Ile Thr Cys Val Leu 290 295 300 Arg His Arg Gly Trp Ser Gly Leu Asp Val Ala Glu Val Glu Glu Ile 305 310 315 320 Leu Gly Ala Asp Ile Thr Ala Glu Val Gly Ser Ile Gln Arg Leu Ala 325 330 335 Lys Ser Val Glu Met His Gly Leu Thr Gly Ser Leu Pro Arg Val Leu 340 345 350 Ser Ser Ala Cys Asp Ala Val Leu Gly Glu Val Ala Ala 355 360 365 <210> 91 <211> 832 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(802) <223> RXA00831 <400> 91 agctccaaga aagtcagtgc tgtgcatggc tcggtgctgc tcatgctttt cggtgtttac 60 atgatgagca tgttcgcctg atttaggtag cctggtggga atg agt gca ctt gag 115 Met Ser Ala Leu Glu 1 5 aca ttg caa tgg cag gac tgg tca agc gtc tta att gtg gta gct cac 163 Thr Leu Gln Trp Gln Asp Trp Ser Ser Val Leu Ile Val Val Ala His 10 15 20 cca gat gat ccg gag tat ggg ctt tcc gcg gct gtt aaa gaa tgg aca 211 Pro Asp Asp Pro Glu Tyr Gly Leu Ser Ala Ala Val Lys Glu Trp Thr 25 30 35 gac gcc ggg gtg gag gtg tct tac ctg ctg ctc acc cac ggg gag gca 259 Asp Ala Gly Val Glu Val Ser Tyr Leu Leu Leu Thr His Gly Glu Ala 40 45 50 ggt atc caa ggt tta gac cct aaa gaa acc ggg tca ttg cgc gca gcg 307 Gly Ile Gln Gly Leu Asp Pro Lys Glu Thr Gly Ser Leu Arg Ala Ala 55 60 65 gaa cag cgg gct gca tgt gat gtg gta gga gtt aga aat ctc acc att 355 Glu Gln Arg Ala Ala Cys Asp Val Val Gly Val Arg Asn Leu Thr Ile 70 75 80 85 ttg aat cac cca gat tcc atg ttg gtg tac aat ctg gta ctg cgc aaa 403 Leu Asn His Pro Asp Ser Met Leu Val Tyr Asn Leu Val Leu Arg Lys 90 95 100 gat att gct cgg gaa atc cgg atc cgt aaa cca aat gct gtg gtg gta 451 Asp Ile Ala Arg Glu Ile Arg Ile Arg Lys Pro Asn Ala Val Val Val 105 110 115 tcc aat ttt gat gta gag gcc tac ggt ggt ttg aac cag gcg gat cac 499 Ser Asn Phe Asp Val Glu Ala Tyr Gly Gly Leu Asn Gln Ala Asp His 120 125 130 cgc gtg gcg gga tta gcc gca att gat gcg acc cgc gat gcc gct aat 547 Arg Val Ala Gly Leu Ala Ala Ile Asp Ala Thr Arg Asp Ala Ala Asn 135 140 145 ccg tgg gcg cag cca gag ctg ttg cag gag gat ctg cag ccg tgg gga 595 Pro Trp Ala Gln Pro Glu Leu Leu Gln Glu Asp Leu Gln Pro Trp Gly 150 155 160 165 gct gaa gtc atc atc att gcc gga cac cca gag ccc acc cac acc atg 643 Ala Glu Val Ile Ile Ile Ala Gly His Pro Glu Pro Thr His Thr Met 170 175 180 gat ctg gct aaa gat tct gtt gat gcc gga gtt gca tcc ctt caa gct 691 Asp Leu Ala Lys Asp Ser Val Asp Ala Gly Val Ala Ser Leu Gln Ala 185 190 195 cac aag gaa tac ttg gcc gct ctt cca gat ccc ccg aag ccg gag gag 739 His Lys Glu Tyr Leu Ala Ala Leu Pro Asp Pro Pro Lys Pro Glu Glu 200 205 210 ttc att ccg gcg ttt ctc gag gta gag ggc ggt tac gca gcg gcc ttc 787 Phe Ile Pro Ala Phe Leu Glu Val Glu Gly Gly Tyr Ala Ala Ala Phe 215 220 225 cga gtt ttc gga cgg taagcagggc gatacgtgat aggcagctta 832 Arg Val Phe Gly Arg 230 <210> 92 <211> 234 <212> PRT <213> Corynebacterium glutamicum <400> 92 Met Ser Ala Leu Glu Thr Leu Gln Trp Gln Asp Trp Ser Ser Val Leu 1 5 10 15 Ile Val Val Ala His Pro Asp Asp Pro Glu Tyr Gly Leu Ser Ala Ala 20 25 30 Val Lys Glu Trp Thr Asp Ala Gly Val Glu Val Ser Tyr Leu Leu Leu 35 40 45 Thr His Gly Glu Ala Gly Ile Gln Gly Leu Asp Pro Lys Glu Thr Gly 50 55 60 Ser Leu Arg Ala Ala Glu Gln Arg Ala Ala Cys Asp Val Val Gly Val 65 70 75 80 Arg Asn Leu Thr Ile Leu Asn His Pro Asp Ser Met Leu Val Tyr Asn 85 90 95 Leu Val Leu Arg Lys Asp Ile Ala Arg Glu Ile Arg Ile Arg Lys Pro 100 105 110 Asn Ala Val Val Val Ser Asn Phe Asp Val Glu Ala Tyr Gly Gly Leu 115 120 125 Asn Gln Ala Asp His Arg Val Ala Gly Leu Ala Ala Ile Asp Ala Thr 130 135 140 Arg Asp Ala Ala Asn Pro Trp Ala Gln Pro Glu Leu Leu Gln Glu Asp 145 150 155 160 Leu Gln Pro Trp Gly Ala Glu Val Ile Ile Ile Ala Gly His Pro Glu 165 170 175 Pro Thr His Thr Met Asp Leu Ala Lys Asp Ser Val Asp Ala Gly Val 180 185 190 Ala Ser Leu Gln Ala His Lys Glu Tyr Leu Ala Ala Leu Pro Asp Pro 195 200 205 Pro Lys Pro Glu Glu Phe Ile Pro Ala Phe Leu Glu Val Glu Gly Gly 210 215 220 Tyr Ala Ala Ala Phe Arg Val Phe Gly Arg 225 230 <210> 93 <211> 1072 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1042) <223> RXA00835 <400> 93 ccaacgatcg caattttcat acctgctatc ttgcctgagc acagataaga tttgtaagca 60 ctaccccttc tctacaaagg agtcatcaat ggccggtgga ttg gca gca cta tta 115 Leu Ala Ala Leu Leu 1 5 gac gat gtc gca gca att act cga gcg gct gca gcc agc ctc gat gat 163 Asp Asp Val Ala Ala Ile Thr Arg Ala Ala Ala Ala Ser Leu Asp Asp 10 15 20 gtc acg gcg atg gct gga aaa acc agc gtt aaa gcc gca ggc gtg gtt 211 Val Thr Ala Met Ala Gly Lys Thr Ser Val Lys Ala Ala Gly Val Val 25 30 35 gta gat gac acg gca gtt acc ccg caa tat gtt caa ggt gtc aaa cct 259 Val Asp Asp Thr Ala Val Thr Pro Gln Tyr Val Gln Gly Val Lys Pro 40 45 50 gca cgc gaa ctg ccc atg att tgg cgg atc gct aag ggc tct ttg gta 307 Ala Arg Glu Leu Pro Met Ile Trp Arg Ile Ala Lys Gly Ser Leu Val 55 60 65 aac aag atc atc atc att ttg ccc atc gcg ttg ctt ctt tcc gcg ttt 355 Asn Lys Ile Ile Ile Ile Leu Pro Ile Ala Leu Leu Leu Ser Ala Phe 70 75 80 85 gct ccg tgg gct ctc aca cca att ttg atg ctg ggc ggc tcc tac ctg 403 Ala Pro Trp Ala Leu Thr Pro Ile Leu Met Leu Gly Gly Ser Tyr Leu 90 95 100 tgc ttc gaa ggt gca gaa aag atc tgg cac tcc ctc cac agg cgc atc 451 Cys Phe Glu Gly Ala Glu Lys Ile Trp His Ser Leu His Arg Arg Ile 105 110 115 aaa ggt gaa cag cac agc acc gaa ccc aag tcg cag gaa agc cca aag 499 Lys Gly Glu Gln His Ser Thr Glu Pro Lys Ser Gln Glu Ser Pro Lys 120 125 130 tca gag gat cag ctg gtc aaa agt gcc atc aca act gac ctc atc ctt 547 Ser Glu Asp Gln Leu Val Lys Ser Ala Ile Thr Thr Asp Leu Ile Leu 135 140 145 tcc gca gag atc atg gtt att tca ctc aat cag att gca gat caa act 595 Ser Ala Glu Ile Met Val Ile Ser Leu Asn Gln Ile Ala Asp Gln Thr 150 155 160 165 atc tgg atg cag gct gcg gtt ctt ttc gtc gta ggt att ggc atc acc 643 Ile Trp Met Gln Ala Ala Val Leu Phe Val Val Gly Ile Gly Ile Thr 170 175 180 gcg ctc gtg tac ggc gta gtc ggt gtt ctt gtg aaa atg gat gac gtc 691 Ala Leu Val Tyr Gly Val Val Gly Val Leu Val Lys Met Asp Asp Val 185 190 195 gga ctt aca ctt tca aag cgt gac tcc gca ggt atc cag aaa ttt ggc 739 Gly Leu Thr Leu Ser Lys Arg Asp Ser Ala Gly Ile Gln Lys Phe Gly 200 205 210 cgc ggc ttg gtc aaa gcg atg ccc atc gtt ctt caa gtt att tct gtt 787 Arg Gly Leu Val Lys Ala Met Pro Ile Val Leu Gln Val Ile Ser Val 215 220 225 gtc ggc gtt ttt gcc atg ctg tgg gtt ggt ggc cac atc atg gtc gtt 835 Val Gly Val Phe Ala Met Leu Trp Val Gly Gly His Ile Met Val Val 230 235 240 245 gga act gaa gag tta gga tgg gaa ctt ccc tac cac ctt gtt cac gga 883 Gly Thr Glu Glu Leu Gly Trp Glu Leu Pro Tyr His Leu Val His Gly 250 255 260 cta gag tcc tgg gct aac ggt atc gga ggc agt gct ctg gga tgg gtt 931 Leu Glu Ser Trp Ala Asn Gly Ile Gly Gly Ser Ala Leu Gly Trp Val 265 270 275 ggc aat act ttc ggg tca ctt gtg ttc ggc ctc att tgg ggc gcg att 979 Gly Asn Thr Phe Gly Ser Leu Val Phe Gly Leu Ile Trp Gly Ala Ile 280 285 290 atc acc gtt gtg gtc agt gtg atc aag aag ttc att cca cag cgt gcg 1027 Ile Thr Val Val Val Ser Val Ile Lys Lys Phe Ile Pro Gln Arg Ala 295 300 305 caa aac tcg tct cat tagtggagag ttgttcgctg taatttcgct 1072 Gln Asn Ser Ser His 310 <210> 94 <211> 314 <212> PRT <213> Corynebacterium glutamicum <400> 94 Leu Ala Ala Leu Leu Asp Asp Val Ala Ala Ile Thr Arg Ala Ala Ala 1 5 10 15 Ala Ser Leu Asp Asp Val Thr Ala Met Ala Gly Lys Thr Ser Val Lys 20 25 30 Ala Ala Gly Val Val Val Asp Asp Thr Ala Val Thr Pro Gln Tyr Val 35 40 45 Gln Gly Val Lys Pro Ala Arg Glu Leu Pro Met Ile Trp Arg Ile Ala 50 55 60 Lys Gly Ser Leu Val Asn Lys Ile Ile Ile Ile Leu Pro Ile Ala Leu 65 70 75 80 Leu Leu Ser Ala Phe Ala Pro Trp Ala Leu Thr Pro Ile Leu Met Leu 85 90 95 Gly Gly Ser Tyr Leu Cys Phe Glu Gly Ala Glu Lys Ile Trp His Ser 100 105 110 Leu His Arg Arg Ile Lys Gly Glu Gln His Ser Thr Glu Pro Lys Ser 115 120 125 Gln Glu Ser Pro Lys Ser Glu Asp Gln Leu Val Lys Ser Ala Ile Thr 130 135 140 Thr Asp Leu Ile Leu Ser Ala Glu Ile Met Val Ile Ser Leu Asn Gln 145 150 155 160 Ile Ala Asp Gln Thr Ile Trp Met Gln Ala Ala Val Leu Phe Val Val 165 170 175 Gly Ile Gly Ile Thr Ala Leu Val Tyr Gly Val Val Gly Val Leu Val 180 185 190 Lys Met Asp Asp Val Gly Leu Thr Leu Ser Lys Arg Asp Ser Ala Gly 195 200 205 Ile Gln Lys Phe Gly Arg Gly Leu Val Lys Ala Met Pro Ile Val Leu 210 215 220 Gln Val Ile Ser Val Val Gly Val Phe Ala Met Leu Trp Val Gly Gly 225 230 235 240 His Ile Met Val Val Gly Thr Glu Glu Leu Gly Trp Glu Leu Pro Tyr 245 250 255 His Leu Val His Gly Leu Glu Ser Trp Ala Asn Gly Ile Gly Gly Ser 260 265 270 Ala Leu Gly Trp Val Gly Asn Thr Phe Gly Ser Leu Val Phe Gly Leu 275 280 285 Ile Trp Gly Ala Ile Ile Thr Val Val Val Ser Val Ile Lys Lys Phe 290 295 300 Ile Pro Gln Arg Ala Gln Asn Ser Ser His 305 310 <210> 95 <211> 2809 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2779) <223> RXA00917 <400> 95 tgccgtggaa gaaagcgctc tttactgcga cagccgtcct attggtgttt gctgttgtgt 60 ggtcggcctt ggatattgcc ctgtgggtag gaaagcagtc atg gtg aac acg ttg 115 Met Val Asn Thr Leu 1 5 aac tct aaa acc gtg aat gta ccc cgt ttt gcc aga ggc gtt gtt gct 163 Asn Ser Lys Thr Val Asn Val Pro Arg Phe Ala Arg Gly Val Val Ala 10 15 20 gca gcc aca gcg cta ttt ttt ggc gct ttg gta agc ctc gcg cct agt 211 Ala Ala Thr Ala Leu Phe Phe Gly Ala Leu Val Ser Leu Ala Pro Ser 25 30 35 gcg ttg gcg cag gaa cca cct gca gtt gag gcc gga gcg tca ggt tct 259 Ala Leu Ala Gln Glu Pro Pro Ala Val Glu Ala Gly Ala Ser Gly Ser 40 45 50 ttg agc aac ctg ggt gcc tgc atc gct gat aaa ggc act ctt gat gtc 307 Leu Ser Asn Leu Gly Ala Cys Ile Ala Asp Lys Gly Thr Leu Asp Val 55 60 65 atc atc atg atc gat gag aca gaa tcc ttg atc cat gaa gct cgt gac 355 Ile Ile Met Ile Asp Glu Thr Glu Ser Leu Ile His Glu Ala Arg Asp 70 75 80 85 ggc gtg gtc aac gcc aat gaa cca ggc gcg gac gca cag cac cac cgt 403 Gly Val Val Asn Ala Asn Glu Pro Gly Ala Asp Ala Gln His His Arg 90 95 100 gtt cct gca gca cag agc ttt gtg gat gag ctt cta gcc aag caa agc 451 Val Pro Ala Ala Gln Ser Phe Val Asp Glu Leu Leu Ala Lys Gln Ser 105 110 115 gat ggt gat ctg aac acc cgc atc cgt gtt gct ggt ttc ggc cag acg 499 Asp Gly Asp Leu Asn Thr Arg Ile Arg Val Ala Gly Phe Gly Gln Thr 120 125 130 tac aaa tct ggt gcc act gat cca gac aat tac gga gca tgg acg caa 547 Tyr Lys Ser Gly Ala Thr Asp Pro Asp Asn Tyr Gly Ala Trp Thr Gln 135 140 145 cta gat gcc tcc acc gtt ggc gga gta caa gat gaa atc tcc cgc ttc 595 Leu Asp Ala Ser Thr Val Gly Gly Val Gln Asp Glu Ile Ser Arg Phe 150 155 160 165 gct gac cgc acc cag gag cag tac acc aac tac gcc tcc gcg att gag 643 Ala Asp Arg Thr Gln Glu Gln Tyr Thr Asn Tyr Ala Ser Ala Ile Glu 170 175 180 ggc gct tac cag gac ttc act agg tcc ggc tct gag gac gcc tgc cgc 691 Gly Ala Tyr Gln Asp Phe Thr Arg Ser Gly Ser Glu Asp Ala Cys Arg 185 190 195 atg ctg gtg acc ttc acc gac ggc gca ctg acc gct caa gaa ggc gcc 739 Met Leu Val Thr Phe Thr Asp Gly Ala Leu Thr Ala Gln Glu Gly Ala 200 205 210 gat gtt gca gaa gca gca ctg tgc gcg ccg ggt ggc gtc acc gat cga 787 Asp Val Ala Glu Ala Ala Leu Cys Ala Pro Gly Gly Val Thr Asp Arg 215 220 225 ctg cgc agt gct ggc atc acc cac atc ggc atc ggt tta tcg gca cct 835 Leu Arg Ser Ala Gly Ile Thr His Ile Gly Ile Gly Leu Ser Ala Pro 230 235 240 245 acc aac cca tct gat ttc agc ctg ctg cgc gga acc acc gca ggt ggc 883 Thr Asn Pro Ser Asp Phe Ser Leu Leu Arg Gly Thr Thr Ala Gly Gly 250 255 260 gga aca tgt ggt gtc gaa cca gct aac ggt gca ttc ttc cca gca gat 931 Gly Thr Cys Gly Val Glu Pro Ala Asn Gly Ala Phe Phe Pro Ala Asp 265 270 275 aac gtg ggc gga ctt ttc gca gca ttc cgt gaa gcc ctt gcg att ggt 979 Asn Val Gly Gly Leu Phe Ala Ala Phe Arg Glu Ala Leu Ala Ile Gly 280 285 290 ggt gaa aca att ggt gaa acc cga gct ggt gat cct ttc agc ttc acc 1027 Gly Glu Thr Ile Gly Glu Thr Arg Ala Gly Asp Pro Phe Ser Phe Thr 295 300 305 ctg gac aac tcg gtg aac tct gtg cgt ttc acc gcg atc gcc aag gat 1075 Leu Asp Asn Ser Val Asn Ser Val Arg Phe Thr Ala Ile Ala Lys Asp 310 315 320 325 gat ctc ggc ccg aac gcc cac ttg gtg ctc acc gca ccc aac ggc gaa 1123 Asp Leu Gly Pro Asn Ala His Leu Val Leu Thr Ala Pro Asn Gly Glu 330 335 340 acg gtt gag ctc aaa gat tct gga agc agc gtc gcc aac agc act gac 1171 Thr Val Glu Leu Lys Asp Ser Gly Ser Ser Val Ala Asn Ser Thr Asp 345 350 355 gtg agt tgg gaa gcc gaa agc agc cca gta aaa atg gct gat ggt tcc 1219 Val Ser Trp Glu Ala Glu Ser Ser Pro Val Lys Met Ala Asp Gly Ser 360 365 370 ctc aac ctg cag caa ggt ggg gat tgg aag ggt gtc tgg cag att cag 1267 Leu Asn Leu Gln Gln Gly Gly Asp Trp Lys Gly Val Trp Gln Ile Gln 375 380 385 ttc caa gga att gat cct gca gcg gtt gat gga cgc gta ttc aac tca 1315 Phe Gln Gly Ile Asp Pro Ala Ala Val Asp Gly Arg Val Phe Asn Ser 390 395 400 405 gtg gag atc cag cct gac ctc cag ctt gtg ttc agt ggc ggt gat tcg 1363 Val Glu Ile Gln Pro Asp Leu Gln Leu Val Phe Ser Gly Gly Asp Ser 410 415 420 acg tca ggt gca ctt aac ctt cgc gat gat cag cag ctg aat atg cag 1411 Thr Ser Gly Ala Leu Asn Leu Arg Asp Asp Gln Gln Leu Asn Met Gln 425 430 435 ctg gtg ggc cgt gat ggt cag cca cgc atc ctt gag ggg tcc gcg ctg 1459 Leu Val Gly Arg Asp Gly Gln Pro Arg Ile Leu Glu Gly Ser Ala Leu 440 445 450 gtc gat ctt ggt ttc acc cgc gca gat acc ggc gag ttc gcc cct ttg 1507 Val Asp Leu Gly Phe Thr Arg Ala Asp Thr Gly Glu Phe Ala Pro Leu 455 460 465 gct caa gga att gat att tct ggc ggc gaa tta agc ttc ccg ctg gat 1555 Ala Gln Gly Ile Asp Ile Ser Gly Gly Glu Leu Ser Phe Pro Leu Asp 470 475 480 485 acg att tcg cag ctc cca gcc atc ggc acg gtg gaa gcg cgt acc acg 1603 Thr Ile Ser Gln Leu Pro Ala Ile Gly Thr Val Glu Ala Arg Thr Thr 490 495 500 atc acc acc gca ggc gtc gat gat ctc ccc ggc acc acg ttg agc cca 1651 Ile Thr Thr Ala Gly Val Asp Asp Leu Pro Gly Thr Thr Leu Ser Pro 505 510 515 att ctc aac acc acg cgc atc acc atc act cag cgc gat atg cct cag 1699 Ile Leu Asn Thr Thr Arg Ile Thr Ile Thr Gln Arg Asp Met Pro Gln 520 525 530 ctg cca gcg tcg gtt cgc ttc aca gcg gat gag gac gtt gtt acc gta 1747 Leu Pro Ala Ser Val Arg Phe Thr Ala Asp Glu Asp Val Val Thr Val 535 540 545 gac atc ccc atc acc ggc ccc ggc aag gta tgg att gca ccg gga acc 1795 Asp Ile Pro Ile Thr Gly Pro Gly Lys Val Trp Ile Ala Pro Gly Thr 550 555 560 565 cag ctc agc gga gtg ctt cca gac ggc gtg gac ggc att gca gca tca 1843 Gln Leu Ser Gly Val Leu Pro Asp Gly Val Asp Gly Ile Ala Ala Ser 570 575 580 agt act ttc gac agc cca gat aat gct ttg gtg ctc gga ctg gat gag 1891 Ser Thr Phe Asp Ser Pro Asp Asn Ala Leu Val Leu Gly Leu Asp Glu 585 590 595 cag ggc acg att cct gtt gaa cta acc gtg agc gat ctt cgt gac gga 1939 Gln Gly Thr Ile Pro Val Glu Leu Thr Val Ser Asp Leu Arg Asp Gly 600 605 610 ctg gtc aac ggc tcg att cca ctc cag atc tcc aac gct gag ggc gcc 1987 Leu Val Asn Gly Ser Ile Pro Leu Gln Ile Ser Asn Ala Glu Gly Ala 615 620 625 aat gaa acc agc gtg gat ctg ccg aca gaa ggc acg ttg agc gtt ccc 2035 Asn Glu Thr Ser Val Asp Leu Pro Thr Glu Gly Thr Leu Ser Val Pro 630 635 640 645 att aac gcc tcc act ttc gca ttg gca ttc att ttg gcc ctt gtg ctt 2083 Ile Asn Ala Ser Thr Phe Ala Leu Ala Phe Ile Leu Ala Leu Val Leu 650 655 660 tcc ctc ctg att ccg ctg ctc att ttg tat att gtg cgt ttc ctc tcc 2131 Ser Leu Leu Ile Pro Leu Leu Ile Leu Tyr Ile Val Arg Phe Leu Ser 665 670 675 gca aag gtt ccg tcc tct gcg atg agt ggc gtg cgc att cca gtg gaa 2179 Ala Lys Val Pro Ser Ser Ala Met Ser Gly Val Arg Ile Pro Val Glu 680 685 690 ttc tcc ggt gaa gct ctg cgc tat gcg ggc agc act atg cct gat ctc 2227 Phe Ser Gly Glu Ala Leu Arg Tyr Ala Gly Ser Thr Met Pro Asp Leu 695 700 705 gca tcg caa acc acc gcc acc aag cag gtc gtt gtt cat gga gac acc 2275 Ala Ser Gln Thr Thr Ala Thr Lys Gln Val Val Val His Gly Asp Thr 710 715 720 725 ttc aat gtg gaa ggc cac aaa ctt aaa gtc cag cgc ttc cag ctg aac 2323 Phe Asn Val Glu Gly His Lys Leu Lys Val Gln Arg Phe Gln Leu Asn 730 735 740 ccg att gcg tct cct gca gtg atc gtg cag acc gac ccg tcg atc agc 2371 Pro Ile Ala Ser Pro Ala Val Ile Val Gln Thr Asp Pro Ser Ile Ser 745 750 755 ttc gac ggc aaa caa aag ggc aca caa gct aaa ctc ccg ctg gcg gtc 2419 Phe Asp Gly Lys Gln Lys Gly Thr Gln Ala Lys Leu Pro Leu Ala Val 760 765 770 caa ggc agt tgg ttc ctc act gca agc ggc gct gac cct tcc aag atg 2467 Gln Gly Ser Trp Phe Leu Thr Ala Ser Gly Ala Asp Pro Ser Lys Met 775 780 785 gaa ctc atc gcc ctg aca aac ctg ccg ctc gag cag ggc caa atc gac 2515 Glu Leu Ile Ala Leu Thr Asn Leu Pro Leu Glu Gln Gly Gln Ile Asp 790 795 800 805 cgc atg atc gca ggt atc acc agc aaa gcc cct gat agg gca cgc gaa 2563 Arg Met Ile Ala Gly Ile Thr Ser Lys Ala Pro Asp Arg Ala Arg Glu 810 815 820 cta caa aaa ttg ctt gac gac gcc gcg acc tcc cag ccc gca aag gtt 2611 Leu Gln Lys Leu Leu Asp Asp Ala Ala Thr Ser Gln Pro Ala Lys Val 825 830 835 cca ccg cgc gcc cca gcc gcg cag ggc cac gtc gaa aag caa gct cct 2659 Pro Pro Arg Ala Pro Ala Ala Gln Gly His Val Glu Lys Gln Ala Pro 840 845 850 agt ttt ggc act ggt tcc ggt ggt ggt ttc ggc tcc agc aat ggt gga 2707 Ser Phe Gly Thr Gly Ser Gly Gly Gly Phe Gly Ser Ser Asn Gly Gly 855 860 865 ggc ttt ggc tcc ggt agc gga tcc aac gac aca aat ggt gga ttt ggt 2755 Gly Phe Gly Ser Gly Ser Gly Ser Asn Asp Thr Asn Gly Gly Phe Gly 870 875 880 885 tcc agc ggc ggc ttc ggc gcg cga taacctgtaa cttgcgatta aaaactaact 2809 Ser Ser Gly Gly Phe Gly Ala Arg 890 <210> 96 <211> 893 <212> PRT <213> Corynebacterium glutamicum <400> 96 Met Val Asn Thr Leu Asn Ser Lys Thr Val Asn Val Pro Arg Phe Ala 1 5 10 15 Arg Gly Val Val Ala Ala Ala Thr Ala Leu Phe Phe Gly Ala Leu Val 20 25 30 Ser Leu Ala Pro Ser Ala Leu Ala Gln Glu Pro Pro Ala Val Glu Ala 35 40 45 Gly Ala Ser Gly Ser Leu Ser Asn Leu Gly Ala Cys Ile Ala Asp Lys 50 55 60 Gly Thr Leu Asp Val Ile Ile Met Ile Asp Glu Thr Glu Ser Leu Ile 65 70 75 80 His Glu Ala Arg Asp Gly Val Val Asn Ala Asn Glu Pro Gly Ala Asp 85 90 95 Ala Gln His His Arg Val Pro Ala Ala Gln Ser Phe Val Asp Glu Leu 100 105 110 Leu Ala Lys Gln Ser Asp Gly Asp Leu Asn Thr Arg Ile Arg Val Ala 115 120 125 Gly Phe Gly Gln Thr Tyr Lys Ser Gly Ala Thr Asp Pro Asp Asn Tyr 130 135 140 Gly Ala Trp Thr Gln Leu Asp Ala Ser Thr Val Gly Gly Val Gln Asp 145 150 155 160 Glu Ile Ser Arg Phe Ala Asp Arg Thr Gln Glu Gln Tyr Thr Asn Tyr 165 170 175 Ala Ser Ala Ile Glu Gly Ala Tyr Gln Asp Phe Thr Arg Ser Gly Ser 180 185 190 Glu Asp Ala Cys Arg Met Leu Val Thr Phe Thr Asp Gly Ala Leu Thr 195 200 205 Ala Gln Glu Gly Ala Asp Val Ala Glu Ala Ala Leu Cys Ala Pro Gly 210 215 220 Gly Val Thr Asp Arg Leu Arg Ser Ala Gly Ile Thr His Ile Gly Ile 225 230 235 240 Gly Leu Ser Ala Pro Thr Asn Pro Ser Asp Phe Ser Leu Leu Arg Gly 245 250 255 Thr Thr Ala Gly Gly Gly Thr Cys Gly Val Glu Pro Ala Asn Gly Ala 260 265 270 Phe Phe Pro Ala Asp Asn Val Gly Gly Leu Phe Ala Ala Phe Arg Glu 275 280 285 Ala Leu Ala Ile Gly Gly Glu Thr Ile Gly Glu Thr Arg Ala Gly Asp 290 295 300 Pro Phe Ser Phe Thr Leu Asp Asn Ser Val Asn Ser Val Arg Phe Thr 305 310 315 320 Ala Ile Ala Lys Asp Asp Leu Gly Pro Asn Ala His Leu Val Leu Thr 325 330 335 Ala Pro Asn Gly Glu Thr Val Glu Leu Lys Asp Ser Gly Ser Ser Val 340 345 350 Ala Asn Ser Thr Asp Val Ser Trp Glu Ala Glu Ser Ser Pro Val Lys 355 360 365 Met Ala Asp Gly Ser Leu Asn Leu Gln Gln Gly Gly Asp Trp Lys Gly 370 375 380 Val Trp Gln Ile Gln Phe Gln Gly Ile Asp Pro Ala Ala Val Asp Gly 385 390 395 400 Arg Val Phe Asn Ser Val Glu Ile Gln Pro Asp Leu Gln Leu Val Phe 405 410 415 Ser Gly Gly Asp Ser Thr Ser Gly Ala Leu Asn Leu Arg Asp Asp Gln 420 425 430 Gln Leu Asn Met Gln Leu Val Gly Arg Asp Gly Gln Pro Arg Ile Leu 435 440 445 Glu Gly Ser Ala Leu Val Asp Leu Gly Phe Thr Arg Ala Asp Thr Gly 450 455 460 Glu Phe Ala Pro Leu Ala Gln Gly Ile Asp Ile Ser Gly Gly Glu Leu 465 470 475 480 Ser Phe Pro Leu Asp Thr Ile Ser Gln Leu Pro Ala Ile Gly Thr Val 485 490 495 Glu Ala Arg Thr Thr Ile Thr Thr Ala Gly Val Asp Asp Leu Pro Gly 500 505 510 Thr Thr Leu Ser Pro Ile Leu Asn Thr Thr Arg Ile Thr Ile Thr Gln 515 520 525 Arg Asp Met Pro Gln Leu Pro Ala Ser Val Arg Phe Thr Ala Asp Glu 530 535 540 Asp Val Val Thr Val Asp Ile Pro Ile Thr Gly Pro Gly Lys Val Trp 545 550 555 560 Ile Ala Pro Gly Thr Gln Leu Ser Gly Val Leu Pro Asp Gly Val Asp 565 570 575 Gly Ile Ala Ala Ser Ser Thr Phe Asp Ser Pro Asp Asn Ala Leu Val 580 585 590 Leu Gly Leu Asp Glu Gln Gly Thr Ile Pro Val Glu Leu Thr Val Ser 595 600 605 Asp Leu Arg Asp Gly Leu Val Asn Gly Ser Ile Pro Leu Gln Ile Ser 610 615 620 Asn Ala Glu Gly Ala Asn Glu Thr Ser Val Asp Leu Pro Thr Glu Gly 625 630 635 640 Thr Leu Ser Val Pro Ile Asn Ala Ser Thr Phe Ala Leu Ala Phe Ile 645 650 655 Leu Ala Leu Val Leu Ser Leu Leu Ile Pro Leu Leu Ile Leu Tyr Ile 660 665 670 Val Arg Phe Leu Ser Ala Lys Val Pro Ser Ser Ala Met Ser Gly Val 675 680 685 Arg Ile Pro Val Glu Phe Ser Gly Glu Ala Leu Arg Tyr Ala Gly Ser 690 695 700 Thr Met Pro Asp Leu Ala Ser Gln Thr Thr Ala Thr Lys Gln Val Val 705 710 715 720 Val His Gly Asp Thr Phe Asn Val Glu Gly His Lys Leu Lys Val Gln 725 730 735 Arg Phe Gln Leu Asn Pro Ile Ala Ser Pro Ala Val Ile Val Gln Thr 740 745 750 Asp Pro Ser Ile Ser Phe Asp Gly Lys Gln Lys Gly Thr Gln Ala Lys 755 760 765 Leu Pro Leu Ala Val Gln Gly Ser Trp Phe Leu Thr Ala Ser Gly Ala 770 775 780 Asp Pro Ser Lys Met Glu Leu Ile Ala Leu Thr Asn Leu Pro Leu Glu 785 790 795 800 Gln Gly Gln Ile Asp Arg Met Ile Ala Gly Ile Thr Ser Lys Ala Pro 805 810 815 Asp Arg Ala Arg Glu Leu Gln Lys Leu Leu Asp Asp Ala Ala Thr Ser 820 825 830 Gln Pro Ala Lys Val Pro Pro Arg Ala Pro Ala Ala Gln Gly His Val 835 840 845 Glu Lys Gln Ala Pro Ser Phe Gly Thr Gly Ser Gly Gly Gly Phe Gly 850 855 860 Ser Ser Asn Gly Gly Gly Phe Gly Ser Gly Ser Gly Ser Asn Asp Thr 865 870 875 880 Asn Gly Gly Phe Gly Ser Ser Gly Gly Phe Gly Ala Arg 885 890 <210> 97 <211> 1042 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1012) <223> RXA00943 <400> 97 taggtacgat cggacgagga gaaaaaatct gaaaacaatc cagtggccca cctcggctta 60 taaaactgga caacagtatt ttgattggag catcaccata atg atc cgc aaa ctt 115 Met Ile Arg Lys Leu 1 5 gct cga cca atg ctt gca tcg gtc tac gtc gca gat ggc gca gaa aca 163 Ala Arg Pro Met Leu Ala Ser Val Tyr Val Ala Asp Gly Ala Glu Thr 10 15 20 gta ttg aac acc agc gca cac gtc gaa ggc act cag gta gtt ctg gat 211 Val Leu Asn Thr Ser Ala His Val Glu Gly Thr Gln Val Val Leu Asp 25 30 35 cgt atc cgt tat gtg ctg ccc cgt aag tac gca aag cgc att tcc aga 259 Arg Ile Arg Tyr Val Leu Pro Arg Lys Tyr Ala Lys Arg Ile Ser Arg 40 45 50 gat cca gaa ttg gtc acc cgc gtc att ggc ggc acc aaa gtc ggt gcg 307 Asp Pro Glu Leu Val Thr Arg Val Ile Gly Gly Thr Lys Val Gly Ala 55 60 65 ggt tct ttg cta gct att ggt cgt gca cca cgc acc tct gca gct acc 355 Gly Ser Leu Leu Ala Ile Gly Arg Ala Pro Arg Thr Ser Ala Ala Thr 70 75 80 85 ctc gca atc ctg act atc cct aac atc ctg gct cgc aat gcg ttc tgg 403 Leu Ala Ile Leu Thr Ile Pro Asn Ile Leu Ala Arg Asn Ala Phe Trp 90 95 100 gaa acc cag gat gcg gat gaa aag cgt aac cgc cgc aac ggt ttc ctc 451 Glu Thr Gln Asp Ala Asp Glu Lys Arg Asn Arg Arg Asn Gly Phe Leu 105 110 115 acc aac att gcc ctg ctt ggt ggc ctg ttt atc act tct gtt gat act 499 Thr Asn Ile Ala Leu Leu Gly Gly Leu Phe Ile Thr Ser Val Asp Thr 120 125 130 gag ggc aag cct ggc gtg aag tgg cgt gca acc aat gct aca aag cgt 547 Glu Gly Lys Pro Gly Val Lys Trp Arg Ala Thr Asn Ala Thr Lys Arg 135 140 145 ggc aag aag cag ctg cag cag gca ctt cca acc aaa tct gag act gaa 595 Gly Lys Lys Gln Leu Gln Gln Ala Leu Pro Thr Lys Ser Glu Thr Glu 150 155 160 165 aag ttc ggt gag aag gcc tct gat tgg ttc aac gat act tct gac aag 643 Lys Phe Gly Glu Lys Ala Ser Asp Trp Phe Asn Asp Thr Ser Asp Lys 170 175 180 gtc acc gag tac gcg tac acc gct cag gat ttt gtc ggt gag aac aag 691 Val Thr Glu Tyr Ala Tyr Thr Ala Gln Asp Phe Val Gly Glu Asn Lys 185 190 195 gat gac tgg atc aag tcc gca acc gag act gct cac aag gtc gct gat 739 Asp Asp Trp Ile Lys Ser Ala Thr Glu Thr Ala His Lys Val Ala Asp 200 205 210 act gtg agc gat tac gct cac aag gct acc tct tac ctt gag gag aac 787 Thr Val Ser Asp Tyr Ala His Lys Ala Thr Ser Tyr Leu Glu Glu Asn 215 220 225 agc ggt gac tgg ctt gag gct gcg cag gct aac gcc aag act gct cgt 835 Ser Gly Asp Trp Leu Glu Ala Ala Gln Ala Asn Ala Lys Thr Ala Arg 230 235 240 245 aag tct gca gtg aag gct gcc ggc aag gct cag gaa aag gct aac ttt 883 Lys Ser Ala Val Lys Ala Ala Gly Lys Ala Gln Glu Lys Ala Asn Phe 250 255 260 gct ctt cag gtc gca gag gaa acc tct ggt cgc gcc aac aag aag gca 931 Ala Leu Gln Val Ala Glu Glu Thr Ser Gly Arg Ala Asn Lys Lys Ala 265 270 275 act aag agc tac gac aag ctt cag aag cag gct gat aag gcc atc gat 979 Thr Lys Ser Tyr Asp Lys Leu Gln Lys Gln Ala Asp Lys Ala Ile Asp 280 285 290 cgt gca cag aag aag ctg aag ggc atc gaa ctt taagtaactt cttcctgatt 1032 Arg Ala Gln Lys Lys Leu Lys Gly Ile Glu Leu 295 300 gagaaaaaat 1042 <210> 98 <211> 304 <212> PRT <213> Corynebacterium glutamicum <400> 98 Met Ile Arg Lys Leu Ala Arg Pro Met Leu Ala Ser Val Tyr Val Ala 1 5 10 15 Asp Gly Ala Glu Thr Val Leu Asn Thr Ser Ala His Val Glu Gly Thr 20 25 30 Gln Val Val Leu Asp Arg Ile Arg Tyr Val Leu Pro Arg Lys Tyr Ala 35 40 45 Lys Arg Ile Ser Arg Asp Pro Glu Leu Val Thr Arg Val Ile Gly Gly 50 55 60 Thr Lys Val Gly Ala Gly Ser Leu Leu Ala Ile Gly Arg Ala Pro Arg 65 70 75 80 Thr Ser Ala Ala Thr Leu Ala Ile Leu Thr Ile Pro Asn Ile Leu Ala 85 90 95 Arg Asn Ala Phe Trp Glu Thr Gln Asp Ala Asp Glu Lys Arg Asn Arg 100 105 110 Arg Asn Gly Phe Leu Thr Asn Ile Ala Leu Leu Gly Gly Leu Phe Ile 115 120 125 Thr Ser Val Asp Thr Glu Gly Lys Pro Gly Val Lys Trp Arg Ala Thr 130 135 140 Asn Ala Thr Lys Arg Gly Lys Lys Gln Leu Gln Gln Ala Leu Pro Thr 145 150 155 160 Lys Ser Glu Thr Glu Lys Phe Gly Glu Lys Ala Ser Asp Trp Phe Asn 165 170 175 Asp Thr Ser Asp Lys Val Thr Glu Tyr Ala Tyr Thr Ala Gln Asp Phe 180 185 190 Val Gly Glu Asn Lys Asp Asp Trp Ile Lys Ser Ala Thr Glu Thr Ala 195 200 205 His Lys Val Ala Asp Thr Val Ser Asp Tyr Ala His Lys Ala Thr Ser 210 215 220 Tyr Leu Glu Glu Asn Ser Gly Asp Trp Leu Glu Ala Ala Gln Ala Asn 225 230 235 240 Ala Lys Thr Ala Arg Lys Ser Ala Val Lys Ala Ala Gly Lys Ala Gln 245 250 255 Glu Lys Ala Asn Phe Ala Leu Gln Val Ala Glu Glu Thr Ser Gly Arg 260 265 270 Ala Asn Lys Lys Ala Thr Lys Ser Tyr Asp Lys Leu Gln Lys Gln Ala 275 280 285 Asp Lys Ala Ile Asp Arg Ala Gln Lys Lys Leu Lys Gly Ile Glu Leu 290 295 300 <210> 99 <211> 967 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(937) <223> RXA00963 <400> 99 ctggctctga cggcgtcgac ttgttctgct tctctgatac accaattttc gaggccctta 60 acctcgcacg tacttttact ccggaaggaa tctagaactt atg cgt ctt gca aca 115 Met Arg Leu Ala Thr 1 5 atc cgc acc aac ggc acc acc att gct gct cgt gtt gaa tct gaa aac 163 Ile Arg Thr Asn Gly Thr Thr Ile Ala Ala Arg Val Glu Ser Glu Asn 10 15 20 acc gct acc acc atc gag ggc ttt gcc aac gtc ggt gaa tta ctc cag 211 Thr Ala Thr Thr Ile Glu Gly Phe Ala Asn Val Gly Glu Leu Leu Gln 25 30 35 gaa tcc aac tgg cgc gag ctg gca gaa aac gct gct ggt gag gct gtg 259 Glu Ser Asn Trp Arg Glu Leu Ala Glu Asn Ala Ala Gly Glu Ala Val 40 45 50 acc ttt gaa aac aag gag cta gat gca gta gtt cca gca cct aag aag 307 Thr Phe Glu Asn Lys Glu Leu Asp Ala Val Val Pro Ala Pro Lys Lys 55 60 65 att gtg tgc gtc ggc ctt aac tac gcc aac cac att aaa gaa atg ggc 355 Ile Val Cys Val Gly Leu Asn Tyr Ala Asn His Ile Lys Glu Met Gly 70 75 80 85 cgc gac ctc cct gat acc cca acc ctt ttt gtt aag ttc cct gac gcg 403 Arg Asp Leu Pro Asp Thr Pro Thr Leu Phe Val Lys Phe Pro Asp Ala 90 95 100 ctc atc gga cct ttc gat gat gtt gtc gtt cca gag tgg gct aac aag 451 Leu Ile Gly Pro Phe Asp Asp Val Val Val Pro Glu Trp Ala Asn Lys 105 110 115 gct ctc gac tgg gaa ggc gag atg gca gtt atc att ggc aag cgc gca 499 Ala Leu Asp Trp Glu Gly Glu Met Ala Val Ile Ile Gly Lys Arg Ala 120 125 130 cgc cgt gtc aag cag gcc gat gct gct gag tac atc gct ggc tac gca 547 Arg Arg Val Lys Gln Ala Asp Ala Ala Glu Tyr Ile Ala Gly Tyr Ala 135 140 145 gtg atg aac gat tac acc acc cgc gat ttc cag tac gca gca cct gca 595 Val Met Asn Asp Tyr Thr Thr Arg Asp Phe Gln Tyr Ala Ala Pro Ala 150 155 160 165 aag act cca cag tgg cac cag ggc aag tct ttg gaa aag tcc gct ggc 643 Lys Thr Pro Gln Trp His Gln Gly Lys Ser Leu Glu Lys Ser Ala Gly 170 175 180 ttc ggg cct tgg atg act acc cca gat tct ttt gag ttc ggc ggc gag 691 Phe Gly Pro Trp Met Thr Thr Pro Asp Ser Phe Glu Phe Gly Gly Glu 185 190 195 ctg gca acc tac ctc gag ggc gag aag gta cag tcc acc cct acc aat 739 Leu Ala Thr Tyr Leu Glu Gly Glu Lys Val Gln Ser Thr Pro Thr Asn 200 205 210 gac ctg gtc ttt agc cca gaa aag ctc atc gaa tac atc acc cac atc 787 Asp Leu Val Phe Ser Pro Glu Lys Leu Ile Glu Tyr Ile Thr His Ile 215 220 225 tac cca ttg gat gct ggc gac gtc att gtc acc ggt acc cca ggc ggc 835 Tyr Pro Leu Asp Ala Gly Asp Val Ile Val Thr Gly Thr Pro Gly Gly 230 235 240 245 gtt ggc cac gca cgt aac cca cag cgc tac atc ggt gac ggc gaa acc 883 Val Gly His Ala Arg Asn Pro Gln Arg Tyr Ile Gly Asp Gly Glu Thr 250 255 260 gta aag gtt gag att gcg ggc ctc ggc ttc att gaa aac aag acg gtg 931 Val Lys Val Glu Ile Ala Gly Leu Gly Phe Ile Glu Asn Lys Thr Val 265 270 275 ttt gaa taaatgacaa ctttccacga tcttccgctg 967 Phe Glu <210> 100 <211> 279 <212> PRT <213> Corynebacterium glutamicum <400> 100 Met Arg Leu Ala Thr Ile Arg Thr Asn Gly Thr Thr Ile Ala Ala Arg 1 5 10 15 Val Glu Ser Glu Asn Thr Ala Thr Thr Ile Glu Gly Phe Ala Asn Val 20 25 30 Gly Glu Leu Leu Gln Glu Ser Asn Trp Arg Glu Leu Ala Glu Asn Ala 35 40 45 Ala Gly Glu Ala Val Thr Phe Glu Asn Lys Glu Leu Asp Ala Val Val 50 55 60 Pro Ala Pro Lys Lys Ile Val Cys Val Gly Leu Asn Tyr Ala Asn His 65 70 75 80 Ile Lys Glu Met Gly Arg Asp Leu Pro Asp Thr Pro Thr Leu Phe Val 85 90 95 Lys Phe Pro Asp Ala Leu Ile Gly Pro Phe Asp Asp Val Val Val Pro 100 105 110 Glu Trp Ala Asn Lys Ala Leu Asp Trp Glu Gly Glu Met Ala Val Ile 115 120 125 Ile Gly Lys Arg Ala Arg Arg Val Lys Gln Ala Asp Ala Ala Glu Tyr 130 135 140 Ile Ala Gly Tyr Ala Val Met Asn Asp Tyr Thr Thr Arg Asp Phe Gln 145 150 155 160 Tyr Ala Ala Pro Ala Lys Thr Pro Gln Trp His Gln Gly Lys Ser Leu 165 170 175 Glu Lys Ser Ala Gly Phe Gly Pro Trp Met Thr Thr Pro Asp Ser Phe 180 185 190 Glu Phe Gly Gly Glu Leu Ala Thr Tyr Leu Glu Gly Glu Lys Val Gln 195 200 205 Ser Thr Pro Thr Asn Asp Leu Val Phe Ser Pro Glu Lys Leu Ile Glu 210 215 220 Tyr Ile Thr His Ile Tyr Pro Leu Asp Ala Gly Asp Val Ile Val Thr 225 230 235 240 Gly Thr Pro Gly Gly Val Gly His Ala Arg Asn Pro Gln Arg Tyr Ile 245 250 255 Gly Asp Gly Glu Thr Val Lys Val Glu Ile Ala Gly Leu Gly Phe Ile 260 265 270 Glu Asn Lys Thr Val Phe Glu 275 <210> 101 <211> 1363 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1333) <223> RXA01011 <400> 101 cccgcaaacc gatttcactc gccgactcat cgacgcgatc ccaggatcgc gctatcgtgg 60 tggcgaactc aatcttggac tataggagca gatcttaaaa atg tca gat ctc atc 115 Met Ser Asp Leu Ile 1 5 gac atg ctg gtt gga gaa gac ctc cca cag ctg cgt gac aac cgt ccc 163 Asp Met Leu Val Gly Glu Asp Leu Pro Gln Leu Arg Asp Asn Arg Pro 10 15 20 caa gct cgc gac aat gca caa aag agc ttc gaa gct ctg ctc gaa ccg 211 Gln Ala Arg Asp Asn Ala Gln Lys Ser Phe Glu Ala Leu Leu Glu Pro 25 30 35 gtc aac cca gga acc ttc agc ttc ggc gag cgt tac gcc gtg gcc acc 259 Val Asn Pro Gly Thr Phe Ser Phe Gly Glu Arg Tyr Ala Val Ala Thr 40 45 50 tat gtt gca ggt ttg cac caa ttc gcg cca gct gta gat ctc tac caa 307 Tyr Val Ala Gly Leu His Gln Phe Ala Pro Ala Val Asp Leu Tyr Gln 55 60 65 gat ttg ctt ctc gac gac gcc cca acc acc ctg gca aac gcc gtc tcc 355 Asp Leu Leu Leu Asp Asp Ala Pro Thr Thr Leu Ala Asn Ala Val Ser 70 75 80 85 gat gcc atc gac gag ggc cta tcc gca ggc cca tac ggc acc tac cgt 403 Asp Ala Ile Asp Glu Gly Leu Ser Ala Gly Pro Tyr Gly Thr Tyr Arg 90 95 100 gaa cct gga ctt gag tcc gaa tca gag cca ggc gga tct gtg cgc aac 451 Glu Pro Gly Leu Glu Ser Glu Ser Glu Pro Gly Gly Ser Val Arg Asn 105 110 115 gat gcc gcc aag ctt ggc gag cga ctt gca gca gca ttt gat tac gca 499 Asp Ala Ala Lys Leu Gly Glu Arg Leu Ala Ala Ala Phe Asp Tyr Ala 120 125 130 cac cta cta gtt ttc cac ccc cgt gat tcc cgc ccc gag gtc ctt ggt 547 His Leu Leu Val Phe His Pro Arg Asp Ser Arg Pro Glu Val Leu Gly 135 140 145 cga ctc tcc ggc gct ggc tgg agc gcg gat gac acc gtg aca ttg gct 595 Arg Leu Ser Gly Ala Gly Trp Ser Ala Asp Asp Thr Val Thr Leu Ala 150 155 160 165 cag ctg gtg tcg ttc ctg gca ttc cag ctg cgt gtt gcc tac ggc ctg 643 Gln Leu Val Ser Phe Leu Ala Phe Gln Leu Arg Val Ala Tyr Gly Leu 170 175 180 cgc acc ctc aaa ggt gaa gac att cag gtg aaa gct cct cgc ctg agt 691 Arg Thr Leu Lys Gly Glu Asp Ile Gln Val Lys Ala Pro Arg Leu Ser 185 190 195 att cct gaa gcg aag tgg gaa ctg tcc aac aac ggc ttt gag atc tcc 739 Ile Pro Glu Ala Lys Trp Glu Leu Ser Asn Asn Gly Phe Glu Ile Ser 200 205 210 acc tat gaa gaa ctc aac cgc cct gaa gcg ttt gtg aac cac tct ttg 787 Thr Tyr Glu Glu Leu Asn Arg Pro Glu Ala Phe Val Asn His Ser Leu 215 220 225 ggc tgg aag cca tgg gta cca cca gta gca aag gca gat ctc acc gaa 835 Gly Trp Lys Pro Trp Val Pro Pro Val Ala Lys Ala Asp Leu Thr Glu 230 235 240 245 gaa cag ctg gat tct ttg atc cag cct gag cgc gct gat atg cca tac 883 Glu Gln Leu Asp Ser Leu Ile Gln Pro Glu Arg Ala Asp Met Pro Tyr 250 255 260 ttc cgt ctc ttg gca cgc gat cct gca gca ttg aag gcg cgt acc ctg 931 Phe Arg Leu Leu Ala Arg Asp Pro Ala Ala Leu Lys Ala Arg Thr Leu 265 270 275 acc gat ctg gat atc ttc ttc aac act gac ggc gaa ggc cta gga cgt 979 Thr Asp Leu Asp Ile Phe Phe Asn Thr Asp Gly Glu Gly Leu Gly Arg 280 285 290 gca gag cgt gaa ctc ggc gcc acc gtt act tcc cgc tac aac ggc tgc 1027 Ala Glu Arg Glu Leu Gly Ala Thr Val Thr Ser Arg Tyr Asn Gly Cys 295 300 305 gtg tac tgc gca tcc gtg cac gca gga cgt gct cag gaa gaa tcc ggt 1075 Val Tyr Cys Ala Ser Val His Ala Gly Arg Ala Gln Glu Glu Ser Gly 310 315 320 325 cga gct gat gat gtc aac gca ctg ttg gca agc atc gac tcc gat ctg 1123 Arg Ala Asp Asp Val Asn Ala Leu Leu Ala Ser Ile Asp Ser Asp Leu 330 335 340 ggt tct gac cag tgg aat gtc atc cgt gac gct gct cgc gca ctg agc 1171 Gly Ser Asp Gln Trp Asn Val Ile Arg Asp Ala Ala Arg Ala Leu Ser 345 350 355 tcc acc cct gct gct ttc aac cag gga tgc atc acc aag ctg cgt ggc 1219 Ser Thr Pro Ala Ala Phe Asn Gln Gly Cys Ile Thr Lys Leu Arg Gly 360 365 370 gtt gga ttc agc gac ctg cag atc gtg gac ttg atc aac tct gtg gcg 1267 Val Gly Phe Ser Asp Leu Gln Ile Val Asp Leu Ile Asn Ser Val Ala 375 380 385 ttc ttc aac tgg gcg aac cgc ctg atg ttg tca ctg ggt gaa ccc gaa 1315 Phe Phe Asn Trp Ala Asn Arg Leu Met Leu Ser Leu Gly Glu Pro Glu 390 395 400 405 gtg cca aag cgt ttc ctg taaaacgcat aaccccgaat accccctgtt 1363 Val Pro Lys Arg Phe Leu 410 <210> 102 <211> 411 <212> PRT <213> Corynebacterium glutamicum <400> 102 Met Ser Asp Leu Ile Asp Met Leu Val Gly Glu Asp Leu Pro Gln Leu 1 5 10 15 Arg Asp Asn Arg Pro Gln Ala Arg Asp Asn Ala Gln Lys Ser Phe Glu 20 25 30 Ala Leu Leu Glu Pro Val Asn Pro Gly Thr Phe Ser Phe Gly Glu Arg 35 40 45 Tyr Ala Val Ala Thr Tyr Val Ala Gly Leu His Gln Phe Ala Pro Ala 50 55 60 Val Asp Leu Tyr Gln Asp Leu Leu Leu Asp Asp Ala Pro Thr Thr Leu 65 70 75 80 Ala Asn Ala Val Ser Asp Ala Ile Asp Glu Gly Leu Ser Ala Gly Pro 85 90 95 Tyr Gly Thr Tyr Arg Glu Pro Gly Leu Glu Ser Glu Ser Glu Pro Gly 100 105 110 Gly Ser Val Arg Asn Asp Ala Ala Lys Leu Gly Glu Arg Leu Ala Ala 115 120 125 Ala Phe Asp Tyr Ala His Leu Leu Val Phe His Pro Arg Asp Ser Arg 130 135 140 Pro Glu Val Leu Gly Arg Leu Ser Gly Ala Gly Trp Ser Ala Asp Asp 145 150 155 160 Thr Val Thr Leu Ala Gln Leu Val Ser Phe Leu Ala Phe Gln Leu Arg 165 170 175 Val Ala Tyr Gly Leu Arg Thr Leu Lys Gly Glu Asp Ile Gln Val Lys 180 185 190 Ala Pro Arg Leu Ser Ile Pro Glu Ala Lys Trp Glu Leu Ser Asn Asn 195 200 205 Gly Phe Glu Ile Ser Thr Tyr Glu Glu Leu Asn Arg Pro Glu Ala Phe 210 215 220 Val Asn His Ser Leu Gly Trp Lys Pro Trp Val Pro Pro Val Ala Lys 225 230 235 240 Ala Asp Leu Thr Glu Glu Gln Leu Asp Ser Leu Ile Gln Pro Glu Arg 245 250 255 Ala Asp Met Pro Tyr Phe Arg Leu Leu Ala Arg Asp Pro Ala Ala Leu 260 265 270 Lys Ala Arg Thr Leu Thr Asp Leu Asp Ile Phe Phe Asn Thr Asp Gly 275 280 285 Glu Gly Leu Gly Arg Ala Glu Arg Glu Leu Gly Ala Thr Val Thr Ser 290 295 300 Arg Tyr Asn Gly Cys Val Tyr Cys Ala Ser Val His Ala Gly Arg Ala 305 310 315 320 Gln Glu Glu Ser Gly Arg Ala Asp Asp Val Asn Ala Leu Leu Ala Ser 325 330 335 Ile Asp Ser Asp Leu Gly Ser Asp Gln Trp Asn Val Ile Arg Asp Ala 340 345 350 Ala Arg Ala Leu Ser Ser Thr Pro Ala Ala Phe Asn Gln Gly Cys Ile 355 360 365 Thr Lys Leu Arg Gly Val Gly Phe Ser Asp Leu Gln Ile Val Asp Leu 370 375 380 Ile Asn Ser Val Ala Phe Phe Asn Trp Ala Asn Arg Leu Met Leu Ser 385 390 395 400 Leu Gly Glu Pro Glu Val Pro Lys Arg Phe Leu 405 410 <210> 103 <211> 739 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(709) <223> RXA01017 <400> 103 gaaatttgag ggggcgctac ccttagaagg tgcgcaatga caccacgata gttcgcgcct 60 agtgtggatt gctagaaaac tttaagaaag aggaaataat atg gct caa aaa gta 115 Met Ala Gln Lys Val 1 5 acc ttc tgg ttc gat acc acc tgc cca ttc tgc tgg gtc acc tcc cgc 163 Thr Phe Trp Phe Asp Thr Thr Cys Pro Phe Cys Trp Val Thr Ser Arg 10 15 20 tgg att aag gaa gtc gaa caa gtc cgc gat att gaa atc cag tgg gtt 211 Trp Ile Lys Glu Val Glu Gln Val Arg Asp Ile Glu Ile Gln Trp Val 25 30 35 cca atg agc ctc gct gtc cta aac gaa ggc cgt gat ctc cca gag gat 259 Pro Met Ser Leu Ala Val Leu Asn Glu Gly Arg Asp Leu Pro Glu Asp 40 45 50 tac aag gag cgc atg aag gct gca tgg gga cca gca cgc gtt ttc gca 307 Tyr Lys Glu Arg Met Lys Ala Ala Trp Gly Pro Ala Arg Val Phe Ala 55 60 65 gct gtc gcc acc gac cat gct gac aag ctc ggc gac ctg tac acc gca 355 Ala Val Ala Thr Asp His Ala Asp Lys Leu Gly Asp Leu Tyr Thr Ala 70 75 80 85 atg ggt acc cgc atc cac aac gac ggt cgc gga cca atc gaa ggt tcc 403 Met Gly Thr Arg Ile His Asn Asp Gly Arg Gly Pro Ile Glu Gly Ser 90 95 100 ttc aat gat gtc atc gca gag gca ctt gaa gag gtc ggc cta gac gct 451 Phe Asn Asp Val Ile Ala Glu Ala Leu Glu Glu Val Gly Leu Asp Ala 105 110 115 gca ctt ggt gaa gtt gca gac acc acc gaa tgg gac gac gca ctt cgc 499 Ala Leu Gly Glu Val Ala Asp Thr Thr Glu Trp Asp Asp Ala Leu Arg 120 125 130 gca ttc cac cag acc gca atg gac gag gtc ggc aac gat gtc gga acc 547 Ala Phe His Gln Thr Ala Met Asp Glu Val Gly Asn Asp Val Gly Thr 135 140 145 cca gtg gtc aag ctc ggc gac acc gct ttc ttc ggc cca gtg ctc acc 595 Pro Val Val Lys Leu Gly Asp Thr Ala Phe Phe Gly Pro Val Leu Thr 150 155 160 165 cgc atc cca cgc ggc gag gaa gca gga gag atc ttc gac gct tcc ttc 643 Arg Ile Pro Arg Gly Glu Glu Ala Gly Glu Ile Phe Asp Ala Ser Phe 170 175 180 aag ctc gca agc tat ccc cac ttc ttt gaa atc aag cgc agc cgc act 691 Lys Leu Ala Ser Tyr Pro His Phe Phe Glu Ile Lys Arg Ser Arg Thr 185 190 195 gag aac cca cag ttc gac taattaacgc tgtctctgct tattaaacac 739 Glu Asn Pro Gln Phe Asp 200 <210> 104 <211> 203 <212> PRT <213> Corynebacterium glutamicum <400> 104 Met Ala Gln Lys Val Thr Phe Trp Phe Asp Thr Thr Cys Pro Phe Cys 1 5 10 15 Trp Val Thr Ser Arg Trp Ile Lys Glu Val Glu Gln Val Arg Asp Ile 20 25 30 Glu Ile Gln Trp Val Pro Met Ser Leu Ala Val Leu Asn Glu Gly Arg 35 40 45 Asp Leu Pro Glu Asp Tyr Lys Glu Arg Met Lys Ala Ala Trp Gly Pro 50 55 60 Ala Arg Val Phe Ala Ala Val Ala Thr Asp His Ala Asp Lys Leu Gly 65 70 75 80 Asp Leu Tyr Thr Ala Met Gly Thr Arg Ile His Asn Asp Gly Arg Gly 85 90 95 Pro Ile Glu Gly Ser Phe Asn Asp Val Ile Ala Glu Ala Leu Glu Glu 100 105 110 Val Gly Leu Asp Ala Ala Leu Gly Glu Val Ala Asp Thr Thr Glu Trp 115 120 125 Asp Asp Ala Leu Arg Ala Phe His Gln Thr Ala Met Asp Glu Val Gly 130 135 140 Asn Asp Val Gly Thr Pro Val Val Lys Leu Gly Asp Thr Ala Phe Phe 145 150 155 160 Gly Pro Val Leu Thr Arg Ile Pro Arg Gly Glu Glu Ala Gly Glu Ile 165 170 175 Phe Asp Ala Ser Phe Lys Leu Ala Ser Tyr Pro His Phe Phe Glu Ile 180 185 190 Lys Arg Ser Arg Thr Glu Asn Pro Gln Phe Asp 195 200 <210> 105 <211> 658 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(628) <223> RXA01037 <400> 105 cgactaaacc gcatcgcttc atggaaatca gccggcgtac agcgctatct caaccccact 60 atctcttaga accacacaca accaagaaag cagtcactac atg acc acc tca tca 115 Met Thr Thr Ser Ser 1 5 ccc ctt aag tcc aaa aat tcc ctt aac ggc gcg cag acc aca ttt gtc 163 Pro Leu Lys Ser Lys Asn Ser Leu Asn Gly Ala Gln Thr Thr Phe Val 10 15 20 cgc aat tgt gtt gca gac ggc cca acc gag gta aaa gcc acc att gat 211 Arg Asn Cys Val Ala Asp Gly Pro Thr Glu Val Lys Ala Thr Ile Asp 25 30 35 gca cgt ggc ggt atc gaa cag ctc cgt gac aat gag att tca cag ctc 259 Ala Arg Gly Gly Ile Glu Gln Leu Arg Asp Asn Glu Ile Ser Gln Leu 40 45 50 ccc gac aag ctg tgg ttc aat agc gca acc tcc gca tcc aat gac gag 307 Pro Asp Lys Leu Trp Phe Asn Ser Ala Thr Ser Ala Ser Asn Asp Glu 55 60 65 ttc acc acc gat aac atc cga ctt ggg ttg ctc tac aac atg gca ctg 355 Phe Thr Thr Asp Asn Ile Arg Leu Gly Leu Leu Tyr Asn Met Ala Leu 70 75 80 85 aat aag gca tcg gct cat cgc tat gag ctt gct gcc cgc tgg tac gcc 403 Asn Lys Ala Ser Ala His Arg Tyr Glu Leu Ala Ala Arg Trp Tyr Ala 90 95 100 att gtt agc cct cag cca tcg caa gaa gct agc cac aag cgc atc gcg 451 Ile Val Ser Pro Gln Pro Ser Gln Glu Ala Ser His Lys Arg Ile Ala 105 110 115 tcc tgg cac ctt acc cag ctg cac gca ctg gtg acc cta tct cgc acc 499 Ser Trp His Leu Thr Gln Leu His Ala Leu Val Thr Leu Ser Arg Thr 120 125 130 cta ggg gtc atc att cct ggt gat gag atc gac gct cta gcg cag tct 547 Leu Gly Val Ile Ile Pro Gly Asp Glu Ile Asp Ala Leu Ala Gln Ser 135 140 145 atg gag aat gct cgt caa gtt ggc acc gag aat tgg tcc act gtc acc 595 Met Glu Asn Ala Arg Gln Val Gly Thr Glu Asn Trp Ser Thr Val Thr 150 155 160 165 atg cgc acc tac gtg acc aac cgc aag gca tcc taatgactcg cgatattttc 648 Met Arg Thr Tyr Val Thr Asn Arg Lys Ala Ser 170 175 cacgaggctg 658 <210> 106 <211> 176 <212> PRT <213> Corynebacterium glutamicum <400> 106 Met Thr Thr Ser Ser Pro Leu Lys Ser Lys Asn Ser Leu Asn Gly Ala 1 5 10 15 Gln Thr Thr Phe Val Arg Asn Cys Val Ala Asp Gly Pro Thr Glu Val 20 25 30 Lys Ala Thr Ile Asp Ala Arg Gly Gly Ile Glu Gln Leu Arg Asp Asn 35 40 45 Glu Ile Ser Gln Leu Pro Asp Lys Leu Trp Phe Asn Ser Ala Thr Ser 50 55 60 Ala Ser Asn Asp Glu Phe Thr Thr Asp Asn Ile Arg Leu Gly Leu Leu 65 70 75 80 Tyr Asn Met Ala Leu Asn Lys Ala Ser Ala His Arg Tyr Glu Leu Ala 85 90 95 Ala Arg Trp Tyr Ala Ile Val Ser Pro Gln Pro Ser Gln Glu Ala Ser 100 105 110 His Lys Arg Ile Ala Ser Trp His Leu Thr Gln Leu His Ala Leu Val 115 120 125 Thr Leu Ser Arg Thr Leu Gly Val Ile Ile Pro Gly Asp Glu Ile Asp 130 135 140 Ala Leu Ala Gln Ser Met Glu Asn Ala Arg Gln Val Gly Thr Glu Asn 145 150 155 160 Trp Ser Thr Val Thr Met Arg Thr Tyr Val Thr Asn Arg Lys Ala Ser 165 170 175 <210> 107 <211> 2038 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2008) <223> RXA01046 <400> 107 actcggcgta cacggaaaat agcagctgat ccatctaggg tcagtgaact ctcgcggatt 60 gccacacacc accaaccact acaagaaaga accccctacc gtg cct ttt cac gat 115 Val Pro Phe His Asp 1 5 ttc act gac cct gat agc gat cct agg caa aat gca cca gct aac ccc 163 Phe Thr Asp Pro Asp Ser Asp Pro Arg Gln Asn Ala Pro Ala Asn Pro 10 15 20 acc gct caa ccg cca tct gcc ccc acc tca cac tca tca cag cag ggt 211 Thr Ala Gln Pro Pro Ser Ala Pro Thr Ser His Ser Ser Gln Gln Gly 25 30 35 ctc cct ccg ggc gcc att atg atc cct ttt cca ggg caa ccg cag cag 259 Leu Pro Pro Gly Ala Ile Met Ile Pro Phe Pro Gly Gln Pro Gln Gln 40 45 50 caa agc gca ccc aat gac gag acc cgt ttc atc gac ctt aac gaa cgt 307 Gln Ser Ala Pro Asn Asp Glu Thr Arg Phe Ile Asp Leu Asn Glu Arg 55 60 65 cat aaa gat gat gaa cca gcc ctg ttt cgc gat gat gtt att gat caa 355 His Lys Asp Asp Glu Pro Ala Leu Phe Arg Asp Asp Val Ile Asp Gln 70 75 80 85 act ctc gct att ttg atc agt aaa aat aag ccc aat gcg cta ctc gtt 403 Thr Leu Ala Ile Leu Ile Ser Lys Asn Lys Pro Asn Ala Leu Leu Val 90 95 100 ggg cct gcc ggt aca ggt aaa tcc cgt atc gca gaa gat att gcg cgc 451 Gly Pro Ala Gly Thr Gly Lys Ser Arg Ile Ala Glu Asp Ile Ala Arg 105 110 115 cgc ctt gcc aat gat gac gta tct att ccc gat cag ctt gtc ggc cac 499 Arg Leu Ala Asn Asp Asp Val Ser Ile Pro Asp Gln Leu Val Gly His 120 125 130 cgt att ctt gat gtc tcc att gca gag ctt gtt gct ggt gct ggc gtt 547 Arg Ile Leu Asp Val Ser Ile Ala Glu Leu Val Ala Gly Ala Gly Val 135 140 145 gtt ggt cag ctc gaa gaa cgc att ctg gat ctc atc aag tat gcg acc 595 Val Gly Gln Leu Glu Glu Arg Ile Leu Asp Leu Ile Lys Tyr Ala Thr 150 155 160 165 gac ccg agt aac aaa gtc att atc ttt att gac gag att cac caa att 643 Asp Pro Ser Asn Lys Val Ile Ile Phe Ile Asp Glu Ile His Gln Ile 170 175 180 gct ggt gat cag tcc agt cac agt gga tcg caa gcc aaa gtt gct cag 691 Ala Gly Asp Gln Ser Ser His Ser Gly Ser Gln Ala Lys Val Ala Gln 185 190 195 att ctc aaa ccc tat ctt gcc cgt ggt gac ctt cgt gtt att ggt gcc 739 Ile Leu Lys Pro Tyr Leu Ala Arg Gly Asp Leu Arg Val Ile Gly Ala 200 205 210 acc acc acc cag gaa gct cgt gac ttc gat cat gat cca gcc ctc aaa 787 Thr Thr Thr Gln Glu Ala Arg Asp Phe Asp His Asp Pro Ala Leu Lys 215 220 225 cgc cgt ttt agc aga gta aat gtc gat gaa ttt gat cga gat caa acg 835 Arg Arg Phe Ser Arg Val Asn Val Asp Glu Phe Asp Arg Asp Gln Thr 230 235 240 245 ctc act att ctt cat gct gca cgt gat ggt tac ctc aaa cat ttc aac 883 Leu Thr Ile Leu His Ala Ala Arg Asp Gly Tyr Leu Lys His Phe Asn 250 255 260 aac gct gtc acg gta tct gac gac gta ctg ggc tat gtc tac acc tac 931 Asn Ala Val Thr Val Ser Asp Asp Val Leu Gly Tyr Val Tyr Thr Tyr 265 270 275 tcg cag caa ttc aac cca ggc aat aca gca caa cct gat gca gca ctg 979 Ser Gln Gln Phe Asn Pro Gly Asn Thr Ala Gln Pro Asp Ala Ala Leu 280 285 290 acg ctg ttt gat aag gcg ttg gct tcc cta act atg gag aaa cag cgt 1027 Thr Leu Phe Asp Lys Ala Leu Ala Ser Leu Thr Met Glu Lys Gln Arg 295 300 305 ctg atc aac aac cat gtc att gcg ccg tcg ctc aag ttc cct gtg tca 1075 Leu Ile Asn Asn His Val Ile Ala Pro Ser Leu Lys Phe Pro Val Ser 310 315 320 325 gaa agg cac atc cat aac acc gct cgc aaa ctt gcc ttt ggc tct caa 1123 Glu Arg His Ile His Asn Thr Ala Arg Lys Leu Ala Phe Gly Ser Gln 330 335 340 gtg cca gcc tcc atc aat act gat gat gct cgt gac aaa ctc gaa acg 1171 Val Pro Ala Ser Ile Asn Thr Asp Asp Ala Arg Asp Lys Leu Glu Thr 345 350 355 ttg ttt ggt caa gat cat att att gag cca gta ctc acc gct atc aag 1219 Leu Phe Gly Gln Asp His Ile Ile Glu Pro Val Leu Thr Ala Ile Lys 360 365 370 cgt gaa cag ctt ggt att ttc cct cgc acc aaa cca ttg agc tgg gtg 1267 Arg Glu Gln Leu Gly Ile Phe Pro Arg Thr Lys Pro Leu Ser Trp Val 375 380 385 ttt gct ggt tca tct ggt gtg ggt aaa aca gaa atg gcg cgt att ctc 1315 Phe Ala Gly Ser Ser Gly Val Gly Lys Thr Glu Met Ala Arg Ile Leu 390 395 400 405 tct cgc gcc att aat ggc ggc gat ccc atc att atc aat ggt ccc gaa 1363 Ser Arg Ala Ile Asn Gly Gly Asp Pro Ile Ile Ile Asn Gly Pro Glu 410 415 420 tac att agt cct gag tcc att act ggc ctt atc gga tca tcc gat ggc 1411 Tyr Ile Ser Pro Glu Ser Ile Thr Gly Leu Ile Gly Ser Ser Asp Gly 425 430 435 tat atc ggc tct aat tct aag cgt gct aaa cca ctc gac ccg ctg att 1459 Tyr Ile Gly Ser Asn Ser Lys Arg Ala Lys Pro Leu Asp Pro Leu Ile 440 445 450 tct aat ccg cgt cag gtg att gtg ctc gat gaa ttt gag aag tct cac 1507 Ser Asn Pro Arg Gln Val Ile Val Leu Asp Glu Phe Glu Lys Ser His 455 460 465 cct cat ttc cag caa ttg ttc atg gca gct ctt gat aca ggc act atg 1555 Pro His Phe Gln Gln Leu Phe Met Ala Ala Leu Asp Thr Gly Thr Met 470 475 480 485 gcg atg gct aat ggc acg aca ttg aat ttc tct cag gcc att atc att 1603 Ala Met Ala Asn Gly Thr Thr Leu Asn Phe Ser Gln Ala Ile Ile Ile 490 495 500 gcc acc acc aat gca gcc cgc gac aaa atc ggt cgt gac agc ttt gga 1651 Ala Thr Thr Asn Ala Ala Arg Asp Lys Ile Gly Arg Asp Ser Phe Gly 505 510 515 ttc gat tca gat aat tca ggt gtc ctc ggt tct gct caa gca gca act 1699 Phe Asp Ser Asp Asn Ser Gly Val Leu Gly Ser Ala Gln Ala Ala Thr 520 525 530 gat ccg cgt gca cag gaa cgc ctc aag tca ctg atg tcc aag gat ttc 1747 Asp Pro Arg Ala Gln Glu Arg Leu Lys Ser Leu Met Ser Lys Asp Phe 535 540 545 cct gtt gaa ctg ctc aac cgt ttc cag aat atc ttt gcc ttc aac cgc 1795 Pro Val Glu Leu Leu Asn Arg Phe Gln Asn Ile Phe Ala Phe Asn Arg 550 555 560 565 att gat gca ggc acc tac cgt gag att ctg gac aat ctc tac cag cgt 1843 Ile Asp Ala Gly Thr Tyr Arg Glu Ile Leu Asp Asn Leu Tyr Gln Arg 570 575 580 cgc cgt gac gcc gtg ctg ctt agc cac ccg cat tac gca gca cag atc 1891 Arg Arg Asp Ala Val Leu Leu Ser His Pro His Tyr Ala Ala Gln Ile 585 590 595 cct gca gat att gat tca gac act ctt gat cag ctg gtg gaa acc acc 1939 Pro Ala Asp Ile Asp Ser Asp Thr Leu Asp Gln Leu Val Glu Thr Thr 600 605 610 ttt atc tca gat ttt ggt gca cgt cct gct gca cgc acc atc gaa gac 1987 Phe Ile Ser Asp Phe Gly Ala Arg Pro Ala Ala Arg Thr Ile Glu Asp 615 620 625 cac atc gca tcc ttg ctg atg tgaccaacct tttaggagta catcatgatt 2038 His Ile Ala Ser Leu Leu Met 630 635 <210> 108 <211> 636 <212> PRT <213> Corynebacterium glutamicum <400> 108 Val Pro Phe His Asp Phe Thr Asp Pro Asp Ser Asp Pro Arg Gln Asn 1 5 10 15 Ala Pro Ala Asn Pro Thr Ala Gln Pro Pro Ser Ala Pro Thr Ser His 20 25 30 Ser Ser Gln Gln Gly Leu Pro Pro Gly Ala Ile Met Ile Pro Phe Pro 35 40 45 Gly Gln Pro Gln Gln Gln Ser Ala Pro Asn Asp Glu Thr Arg Phe Ile 50 55 60 Asp Leu Asn Glu Arg His Lys Asp Asp Glu Pro Ala Leu Phe Arg Asp 65 70 75 80 Asp Val Ile Asp Gln Thr Leu Ala Ile Leu Ile Ser Lys Asn Lys Pro 85 90 95 Asn Ala Leu Leu Val Gly Pro Ala Gly Thr Gly Lys Ser Arg Ile Ala 100 105 110 Glu Asp Ile Ala Arg Arg Leu Ala Asn Asp Asp Val Ser Ile Pro Asp 115 120 125 Gln Leu Val Gly His Arg Ile Leu Asp Val Ser Ile Ala Glu Leu Val 130 135 140 Ala Gly Ala Gly Val Val Gly Gln Leu Glu Glu Arg Ile Leu Asp Leu 145 150 155 160 Ile Lys Tyr Ala Thr Asp Pro Ser Asn Lys Val Ile Ile Phe Ile Asp 165 170 175 Glu Ile His Gln Ile Ala Gly Asp Gln Ser Ser His Ser Gly Ser Gln 180 185 190 Ala Lys Val Ala Gln Ile Leu Lys Pro Tyr Leu Ala Arg Gly Asp Leu 195 200 205 Arg Val Ile Gly Ala Thr Thr Thr Gln Glu Ala Arg Asp Phe Asp His 210 215 220 Asp Pro Ala Leu Lys Arg Arg Phe Ser Arg Val Asn Val Asp Glu Phe 225 230 235 240 Asp Arg Asp Gln Thr Leu Thr Ile Leu His Ala Ala Arg Asp Gly Tyr 245 250 255 Leu Lys His Phe Asn Asn Ala Val Thr Val Ser Asp Asp Val Leu Gly 260 265 270 Tyr Val Tyr Thr Tyr Ser Gln Gln Phe Asn Pro Gly Asn Thr Ala Gln 275 280 285 Pro Asp Ala Ala Leu Thr Leu Phe Asp Lys Ala Leu Ala Ser Leu Thr 290 295 300 Met Glu Lys Gln Arg Leu Ile Asn Asn His Val Ile Ala Pro Ser Leu 305 310 315 320 Lys Phe Pro Val Ser Glu Arg His Ile His Asn Thr Ala Arg Lys Leu 325 330 335 Ala Phe Gly Ser Gln Val Pro Ala Ser Ile Asn Thr Asp Asp Ala Arg 340 345 350 Asp Lys Leu Glu Thr Leu Phe Gly Gln Asp His Ile Ile Glu Pro Val 355 360 365 Leu Thr Ala Ile Lys Arg Glu Gln Leu Gly Ile Phe Pro Arg Thr Lys 370 375 380 Pro Leu Ser Trp Val Phe Ala Gly Ser Ser Gly Val Gly Lys Thr Glu 385 390 395 400 Met Ala Arg Ile Leu Ser Arg Ala Ile Asn Gly Gly Asp Pro Ile Ile 405 410 415 Ile Asn Gly Pro Glu Tyr Ile Ser Pro Glu Ser Ile Thr Gly Leu Ile 420 425 430 Gly Ser Ser Asp Gly Tyr Ile Gly Ser Asn Ser Lys Arg Ala Lys Pro 435 440 445 Leu Asp Pro Leu Ile Ser Asn Pro Arg Gln Val Ile Val Leu Asp Glu 450 455 460 Phe Glu Lys Ser His Pro His Phe Gln Gln Leu Phe Met Ala Ala Leu 465 470 475 480 Asp Thr Gly Thr Met Ala Met Ala Asn Gly Thr Thr Leu Asn Phe Ser 485 490 495 Gln Ala Ile Ile Ile Ala Thr Thr Asn Ala Ala Arg Asp Lys Ile Gly 500 505 510 Arg Asp Ser Phe Gly Phe Asp Ser Asp Asn Ser Gly Val Leu Gly Ser 515 520 525 Ala Gln Ala Ala Thr Asp Pro Arg Ala Gln Glu Arg Leu Lys Ser Leu 530 535 540 Met Ser Lys Asp Phe Pro Val Glu Leu Leu Asn Arg Phe Gln Asn Ile 545 550 555 560 Phe Ala Phe Asn Arg Ile Asp Ala Gly Thr Tyr Arg Glu Ile Leu Asp 565 570 575 Asn Leu Tyr Gln Arg Arg Arg Asp Ala Val Leu Leu Ser His Pro His 580 585 590 Tyr Ala Ala Gln Ile Pro Ala Asp Ile Asp Ser Asp Thr Leu Asp Gln 595 600 605 Leu Val Glu Thr Thr Phe Ile Ser Asp Phe Gly Ala Arg Pro Ala Ala 610 615 620 Arg Thr Ile Glu Asp His Ile Ala Ser Leu Leu Met 625 630 635 <210> 109 <211> 772 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(742) <223> RXA01109 <400> 109 gggtcgtcag ctagattgct ttgctagggt aatctgcgtg aaccgtccgg gaatttttaa 60 gttttccgga gcatgtcgat gatttatcag gagcagaact ttg tct att agc ctt 115 Leu Ser Ile Ser Leu 1 5 tcc tca aag aag gtt gct ttc gca gca ctc atg gtc acc cca ctt ctc 163 Ser Ser Lys Lys Val Ala Phe Ala Ala Leu Met Val Thr Pro Leu Leu 10 15 20 ttg acc gca tgt ggc agt gat tca tct gat act gaa gca gcc tca tcc 211 Leu Thr Ala Cys Gly Ser Asp Ser Ser Asp Thr Glu Ala Ala Ser Ser 25 30 35 agc gca gcg acg acg aca aat tct tcc tca tcc agc gca gcg acc tcg 259 Ser Ala Ala Thr Thr Thr Asn Ser Ser Ser Ser Ser Ala Ala Thr Ser 40 45 50 gcg gaa gca gca gaa acc acc tcg tcc gaa tct gaa tct tcc gaa gca 307 Ala Glu Ala Ala Glu Thr Thr Ser Ser Glu Ser Glu Ser Ser Glu Ala 55 60 65 aca acc atc aac gaa gag cag caa gca cag ctt gat gta ctg tct caa 355 Thr Thr Ile Asn Glu Glu Gln Gln Ala Gln Leu Asp Val Leu Ser Gln 70 75 80 85 gag ctg tct gag aac cca att acc ttc gct gaa gct gcg cca gtt gaa 403 Glu Leu Ser Glu Asn Pro Ile Thr Phe Ala Glu Ala Ala Pro Val Glu 90 95 100 aac ggc gag acc gct tcc cca gaa gac aca gct gcc atc gag gct ctg 451 Asn Gly Glu Thr Ala Ser Pro Glu Asp Thr Ala Ala Ile Glu Ala Leu 105 110 115 gtt cgc gga tac act gac acc aac acc ttg cgt agc tcc ctt gcg tac 499 Val Arg Gly Tyr Thr Asp Thr Asn Thr Leu Arg Ser Ser Leu Ala Tyr 120 125 130 acc atc aac aac acc tgc acc cgc gtt ctt gaa gcc agc ggc gct gac 547 Thr Ile Asn Asn Thr Cys Thr Arg Val Leu Glu Ala Ser Gly Ala Asp 135 140 145 gct acc cag ctt gat ctc aac acc atc cct gat atc cca ctg ggt ggc 595 Ala Thr Gln Leu Asp Leu Asn Thr Ile Pro Asp Ile Pro Leu Gly Gly 150 155 160 165 gaa ggc acc gga act gtt gat tcc atc acc gat gtt gtg gtc aac ggc 643 Glu Gly Thr Gly Thr Val Asp Ser Ile Thr Asp Val Val Val Asn Gly 170 175 180 cag gaa gca tcc gca tgg gtc gta gca acc gcc ggt gga acc acc gac 691 Gln Glu Ala Ser Ala Trp Val Val Ala Thr Ala Gly Gly Thr Thr Asp 185 190 195 tct gca acc cag cgc ttc ttc aac gaa ggt ggc cag tgg aag ttc tgc 739 Ser Ala Thr Gln Arg Phe Phe Asn Glu Gly Gly Gln Trp Lys Phe Cys 200 205 210 gac taatccacag agcttaaaac tccggttgtc 772 Asp <210> 110 <211> 214 <212> PRT <213> Corynebacterium glutamicum <400> 110 Leu Ser Ile Ser Leu Ser Ser Lys Lys Val Ala Phe Ala Ala Leu Met 1 5 10 15 Val Thr Pro Leu Leu Leu Thr Ala Cys Gly Ser Asp Ser Ser Asp Thr 20 25 30 Glu Ala Ala Ser Ser Ser Ala Ala Thr Thr Thr Asn Ser Ser Ser Ser 35 40 45 Ser Ala Ala Thr Ser Ala Glu Ala Ala Glu Thr Thr Ser Ser Glu Ser 50 55 60 Glu Ser Ser Glu Ala Thr Thr Ile Asn Glu Glu Gln Gln Ala Gln Leu 65 70 75 80 Asp Val Leu Ser Gln Glu Leu Ser Glu Asn Pro Ile Thr Phe Ala Glu 85 90 95 Ala Ala Pro Val Glu Asn Gly Glu Thr Ala Ser Pro Glu Asp Thr Ala 100 105 110 Ala Ile Glu Ala Leu Val Arg Gly Tyr Thr Asp Thr Asn Thr Leu Arg 115 120 125 Ser Ser Leu Ala Tyr Thr Ile Asn Asn Thr Cys Thr Arg Val Leu Glu 130 135 140 Ala Ser Gly Ala Asp Ala Thr Gln Leu Asp Leu Asn Thr Ile Pro Asp 145 150 155 160 Ile Pro Leu Gly Gly Glu Gly Thr Gly Thr Val Asp Ser Ile Thr Asp 165 170 175 Val Val Val Asn Gly Gln Glu Ala Ser Ala Trp Val Val Ala Thr Ala 180 185 190 Gly Gly Thr Thr Asp Ser Ala Thr Gln Arg Phe Phe Asn Glu Gly Gly 195 200 205 Gln Trp Lys Phe Cys Asp 210 <210> 111 <211> 652 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(622) <223> RXA01122 <400> 111 tattcgacca aggctgagca aaaaggcgct aagctgtggg gagatcgcaa gcccctatcc 60 ggcctctact aagccccgaa gttgaaggga aactccccca atg ccg ttt cca gca 115 Met Pro Phe Pro Ala 1 5 ctg ttg ttg ccg ctg att ttc tgg aca gga att gca gct ttg tcc tct 163 Leu Leu Leu Pro Leu Ile Phe Trp Thr Gly Ile Ala Ala Leu Ser Ser 10 15 20 tgg gcg gtc agc cgt gca ctt ccg ctg cgc gcc gat aat tcc att gag 211 Trp Ala Val Ser Arg Ala Leu Pro Leu Arg Ala Asp Asn Ser Ile Glu 25 30 35 att gat gcg ccg gtg gaa aag gtc tgg gat ttc atc gag gag acc aac 259 Ile Asp Ala Pro Val Glu Lys Val Trp Asp Phe Ile Glu Glu Thr Asn 40 45 50 cgc gtg ccg gag tgg aat gag cac att ctg tac gtg cag gcg cct ggt 307 Arg Val Pro Glu Trp Asn Glu His Ile Leu Tyr Val Gln Ala Pro Gly 55 60 65 gag atc gag cag ggc atg aag ctc aag atg aaa aca agg cac cca gag 355 Glu Ile Glu Gln Gly Met Lys Leu Lys Met Lys Thr Arg His Pro Glu 70 75 80 85 acc aat cgc ctc act ttg aag ttt cgc ccc acc atc gac gtg ctg cgt 403 Thr Asn Arg Leu Thr Leu Lys Phe Arg Pro Thr Ile Asp Val Leu Arg 90 95 100 cca cac cgt gaa ttg acg tgg tcc acc aaa att gtt gcg cgt tgg ctg 451 Pro His Arg Glu Leu Thr Trp Ser Thr Lys Ile Val Ala Arg Trp Leu 105 110 115 ctc acc gtc acc gac acg atc gag ctg aag cct ttg gaa gat ggt cgc 499 Leu Thr Val Thr Asp Thr Ile Glu Leu Lys Pro Leu Glu Asp Gly Arg 120 125 130 act gag gtg gat caa tca atg tcc ttt agt ggc gta cta tcc ccc gga 547 Thr Glu Val Asp Gln Ser Met Ser Phe Ser Gly Val Leu Ser Pro Gly 135 140 145 gtg ccc ttt ttg gcc agc atc agc agg atc aaa gag aac tca aac cgc 595 Val Pro Phe Leu Ala Ser Ile Ser Arg Ile Lys Glu Asn Ser Asn Arg 150 155 160 165 cag ttg aaa gca ctg atc gaa gcc gag taaacctcca acccctacat 642 Gln Leu Lys Ala Leu Ile Glu Ala Glu 170 aacgtggggg 652 <210> 112 <211> 174 <212> PRT <213> Corynebacterium glutamicum <400> 112 Met Pro Phe Pro Ala Leu Leu Leu Pro Leu Ile Phe Trp Thr Gly Ile 1 5 10 15 Ala Ala Leu Ser Ser Trp Ala Val Ser Arg Ala Leu Pro Leu Arg Ala 20 25 30 Asp Asn Ser Ile Glu Ile Asp Ala Pro Val Glu Lys Val Trp Asp Phe 35 40 45 Ile Glu Glu Thr Asn Arg Val Pro Glu Trp Asn Glu His Ile Leu Tyr 50 55 60 Val Gln Ala Pro Gly Glu Ile Glu Gln Gly Met Lys Leu Lys Met Lys 65 70 75 80 Thr Arg His Pro Glu Thr Asn Arg Leu Thr Leu Lys Phe Arg Pro Thr 85 90 95 Ile Asp Val Leu Arg Pro His Arg Glu Leu Thr Trp Ser Thr Lys Ile 100 105 110 Val Ala Arg Trp Leu Leu Thr Val Thr Asp Thr Ile Glu Leu Lys Pro 115 120 125 Leu Glu Asp Gly Arg Thr Glu Val Asp Gln Ser Met Ser Phe Ser Gly 130 135 140 Val Leu Ser Pro Gly Val Pro Phe Leu Ala Ser Ile Ser Arg Ile Lys 145 150 155 160 Glu Asn Ser Asn Arg Gln Leu Lys Ala Leu Ile Glu Ala Glu 165 170 <210> 113 <211> 1171 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1141) <223> RXA01127 <400> 113 aacgatttcc agttgagtca agccctgcat gatggggtag tgggggttgt tgggcaggta 60 cgagctgtga tcaatcagct acactagtga agtccatata gtg aga agg gaa tcc 115 Val Arg Arg Glu Ser 1 5 cac aac atg aaa ctt gct gtt att ggt gga gat ggt atc ggc cca gag 163 His Asn Met Lys Leu Ala Val Ile Gly Gly Asp Gly Ile Gly Pro Glu 10 15 20 gtt act gca gaa gcc ctc aag gtt cta aac gct gtc cgc gac gac atc 211 Val Thr Ala Glu Ala Leu Lys Val Leu Asn Ala Val Arg Asp Asp Ile 25 30 35 gag acc acc gat tat gac ctt ggc gca cgc cgt tac ctc aaa aat ggc 259 Glu Thr Thr Asp Tyr Asp Leu Gly Ala Arg Arg Tyr Leu Lys Asn Gly 40 45 50 gag ctg ctc acc gac gag gat ctg gca tcc ctg cgc gag cat gac gcg 307 Glu Leu Leu Thr Asp Glu Asp Leu Ala Ser Leu Arg Glu His Asp Ala 55 60 65 atc ctt ctt ggc gct atc ggt gca cca ggt tcc gtc cct cca gga att 355 Ile Leu Leu Gly Ala Ile Gly Ala Pro Gly Ser Val Pro Pro Gly Ile 70 75 80 85 ctc gag cgt ggt ttg ctg ctg aag atg cga ttc gca ctg gat cac cac 403 Leu Glu Arg Gly Leu Leu Leu Lys Met Arg Phe Ala Leu Asp His His 90 95 100 gtg aac ctg cgc cca tcc aag ctg tac gac ggc gtg gag tcc cca ctg 451 Val Asn Leu Arg Pro Ser Lys Leu Tyr Asp Gly Val Glu Ser Pro Leu 105 110 115 cgt aac cca ggc aag att gat ttc gtt gtg gtc cgc gaa ggt acc gaa 499 Arg Asn Pro Gly Lys Ile Asp Phe Val Val Val Arg Glu Gly Thr Glu 120 125 130 ggc gcc tac act ggc aac ggt gga gca atc cgc gtg gga acc cct cac 547 Gly Ala Tyr Thr Gly Asn Gly Gly Ala Ile Arg Val Gly Thr Pro His 135 140 145 gag att gcc aat gaa acc tcc gtg aac act cgc tac ggc gct gag cgc 595 Glu Ile Ala Asn Glu Thr Ser Val Asn Thr Arg Tyr Gly Ala Glu Arg 150 155 160 165 gtt att cgc tac gca ttc gag ctg gca cag agc cgc cgc aag aag ctc 643 Val Ile Arg Tyr Ala Phe Glu Leu Ala Gln Ser Arg Arg Lys Lys Leu 170 175 180 acc ctc gtg cac aag acc aac gtc ctg gtt cac ggt ggt ggc ctg tgg 691 Thr Leu Val His Lys Thr Asn Val Leu Val His Gly Gly Gly Leu Trp 185 190 195 cag cgc acc gta gat gag gtt gca aag gaa tac cca gag gta gcc gtc 739 Gln Arg Thr Val Asp Glu Val Ala Lys Glu Tyr Pro Glu Val Ala Val 200 205 210 gat tac aac cac atc gat gca gca acc atc tat ctg gtc act gat cct 787 Asp Tyr Asn His Ile Asp Ala Ala Thr Ile Tyr Leu Val Thr Asp Pro 215 220 225 tcc cgc ttc gat gtg att gtt acc gat aac ctc ttc ggc gac atc ctc 835 Ser Arg Phe Asp Val Ile Val Thr Asp Asn Leu Phe Gly Asp Ile Leu 230 235 240 245 acc gat gag gca ggc gca gtc tct ggc gga att ggc ctc gca gca tcc 883 Thr Asp Glu Ala Gly Ala Val Ser Gly Gly Ile Gly Leu Ala Ala Ser 250 255 260 ggc aac atc gat gcc acg ggc acc aac cct tcc atg ttc gag cca gtc 931 Gly Asn Ile Asp Ala Thr Gly Thr Asn Pro Ser Met Phe Glu Pro Val 265 270 275 cac ggc tct gca cca gat atc gca ggc cag gga atc gca gac cca acg 979 His Gly Ser Ala Pro Asp Ile Ala Gly Gln Gly Ile Ala Asp Pro Thr 280 285 290 gca gca atc cta tcc gct gcg atg ctg ctg cgt cac tta ggt gat gaa 1027 Ala Ala Ile Leu Ser Ala Ala Met Leu Leu Arg His Leu Gly Asp Glu 295 300 305 gac aac gca gta cgt att gaa aca gcc atc gca gct gat gtg gct ggc 1075 Asp Asn Ala Val Arg Ile Glu Thr Ala Ile Ala Ala Asp Val Ala Gly 310 315 320 325 cga gat aac tct cag ccg att tct acc act gag gtg gga gac cgc atc 1123 Arg Asp Asn Ser Gln Pro Ile Ser Thr Thr Glu Val Gly Asp Arg Ile 330 335 340 gtc aag gcg ctg caa agc taaatttcaa cgccgacccc cttgcctttt 1171 Val Lys Ala Leu Gln Ser 345 <210> 114 <211> 347 <212> PRT <213> Corynebacterium glutamicum <400> 114 Val Arg Arg Glu Ser His Asn Met Lys Leu Ala Val Ile Gly Gly Asp 1 5 10 15 Gly Ile Gly Pro Glu Val Thr Ala Glu Ala Leu Lys Val Leu Asn Ala 20 25 30 Val Arg Asp Asp Ile Glu Thr Thr Asp Tyr Asp Leu Gly Ala Arg Arg 35 40 45 Tyr Leu Lys Asn Gly Glu Leu Leu Thr Asp Glu Asp Leu Ala Ser Leu 50 55 60 Arg Glu His Asp Ala Ile Leu Leu Gly Ala Ile Gly Ala Pro Gly Ser 65 70 75 80 Val Pro Pro Gly Ile Leu Glu Arg Gly Leu Leu Leu Lys Met Arg Phe 85 90 95 Ala Leu Asp His His Val Asn Leu Arg Pro Ser Lys Leu Tyr Asp Gly 100 105 110 Val Glu Ser Pro Leu Arg Asn Pro Gly Lys Ile Asp Phe Val Val Val 115 120 125 Arg Glu Gly Thr Glu Gly Ala Tyr Thr Gly Asn Gly Gly Ala Ile Arg 130 135 140 Val Gly Thr Pro His Glu Ile Ala Asn Glu Thr Ser Val Asn Thr Arg 145 150 155 160 Tyr Gly Ala Glu Arg Val Ile Arg Tyr Ala Phe Glu Leu Ala Gln Ser 165 170 175 Arg Arg Lys Lys Leu Thr Leu Val His Lys Thr Asn Val Leu Val His 180 185 190 Gly Gly Gly Leu Trp Gln Arg Thr Val Asp Glu Val Ala Lys Glu Tyr 195 200 205 Pro Glu Val Ala Val Asp Tyr Asn His Ile Asp Ala Ala Thr Ile Tyr 210 215 220 Leu Val Thr Asp Pro Ser Arg Phe Asp Val Ile Val Thr Asp Asn Leu 225 230 235 240 Phe Gly Asp Ile Leu Thr Asp Glu Ala Gly Ala Val Ser Gly Gly Ile 245 250 255 Gly Leu Ala Ala Ser Gly Asn Ile Asp Ala Thr Gly Thr Asn Pro Ser 260 265 270 Met Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Gln Gly 275 280 285 Ile Ala Asp Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Leu Leu Arg 290 295 300 His Leu Gly Asp Glu Asp Asn Ala Val Arg Ile Glu Thr Ala Ile Ala 305 310 315 320 Ala Asp Val Ala Gly Arg Asp Asn Ser Gln Pro Ile Ser Thr Thr Glu 325 330 335 Val Gly Asp Arg Ile Val Lys Ala Leu Gln Ser 340 345 <210> 115 <211> 1192 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1162) <223> RXA01128 <400> 115 tgagattaac cataaaagaa aaactgcctc attgtctcga aatcctgcat tcgagtacaa 60 ataaatttga gaacaaaaag atggggggaa atatgttaaa gtg cgt tat att gct 115 Val Arg Tyr Ile Ala 1 5 tta gcg aaa gta act tcc atg cat caa cgt tcg atg agc ttc act ttc 163 Leu Ala Lys Val Thr Ser Met His Gln Arg Ser Met Ser Phe Thr Phe 10 15 20 att cgt act ttt ttc gta ctt ttt ggc atc acg ttg tta gtg tca tgc 211 Ile Arg Thr Phe Phe Val Leu Phe Gly Ile Thr Leu Leu Val Ser Cys 25 30 35 gtt cca gag cct cct gac tcc tac act aaa gaa tcc act gtg ctg cgg 259 Val Pro Glu Pro Pro Asp Ser Tyr Thr Lys Glu Ser Thr Val Leu Arg 40 45 50 tat cag gtc tct gat ttc aat cta aac ttc gtg gaa tta gca gtt gcg 307 Tyr Gln Val Ser Asp Phe Asn Leu Asn Phe Val Glu Leu Ala Val Ala 55 60 65 ctt ggg tat ttg aac aac att gag ctc caa gta gtc gga tct gta caa 355 Leu Gly Tyr Leu Asn Asn Ile Glu Leu Gln Val Val Gly Ser Val Gln 70 75 80 85 ggc ggc gtt gag tcc att gaa tcg ctc aaa aag gat gac att gac ttc 403 Gly Gly Val Glu Ser Ile Glu Ser Leu Lys Lys Asp Asp Ile Asp Phe 90 95 100 gcg gca gtc ccc ttc att ggc ctt gtt gca gga gag ata gcc acc ggt 451 Ala Ala Val Pro Phe Ile Gly Leu Val Ala Gly Glu Ile Ala Thr Gly 105 110 115 gcg ccc atc aaa gca gtg gcc gca agt tac gga att tcc cac gat tct 499 Ala Pro Ile Lys Ala Val Ala Ala Ser Tyr Gly Ile Ser His Asp Ser 120 125 130 tct tct gca ctt cta gtc ctt aaa gac agt gag ata cac gaa gtg cac 547 Ser Ser Ala Leu Leu Val Leu Lys Asp Ser Glu Ile His Glu Val His 135 140 145 gat ctc att ggc aaa aca gtt ggc ata aac acc ctc ggt gct ctg gga 595 Asp Leu Ile Gly Lys Thr Val Gly Ile Asn Thr Leu Gly Ala Leu Gly 150 155 160 165 tct gcg atg gtt gag cgt cat cta ttc gac gcc ggt ctc acc gaa cct 643 Ser Ala Met Val Glu Arg His Leu Phe Asp Ala Gly Leu Thr Glu Pro 170 175 180 gag atc gtg agc gtc act caa cgt gca tta ccc ggt gag tac tta gaa 691 Glu Ile Val Ser Val Thr Gln Arg Ala Leu Pro Gly Glu Tyr Leu Glu 185 190 195 caa cgc ctc tac cag ggg caa gtt gat gca att tgg gtc acc gat agc 739 Gln Arg Leu Tyr Gln Gly Gln Val Asp Ala Ile Trp Val Thr Asp Ser 200 205 210 gct aaa cac caa gcg ctt gaa act gga gat ttt cgg atc ttg gca gag 787 Ala Lys His Gln Ala Leu Glu Thr Gly Asp Phe Arg Ile Leu Ala Glu 215 220 225 gat tca gac ctt gtg cag gaa ctc aac act ggc tgc atg gtg gtg tcg 835 Asp Ser Asp Leu Val Gln Glu Leu Asn Thr Gly Cys Met Val Val Ser 230 235 240 245 caa aaa ctc atc gac gag cac ccc gca gtg gtt gga gaa tta gtg gat 883 Gln Lys Leu Ile Asp Glu His Pro Ala Val Val Gly Glu Leu Val Asp 250 255 260 gga gta gct cag gca atc gag ttt gaa cga tcc cac tcc cct gaa gaa 931 Gly Val Ala Gln Ala Ile Glu Phe Glu Arg Ser His Ser Pro Glu Glu 265 270 275 gtg cgc gaa gtt tat ttc aac tac ctc gaa gcc cat ggt cag agt gat 979 Val Arg Glu Val Tyr Phe Asn Tyr Leu Glu Ala His Gly Gln Ser Asp 280 285 290 aga ata tcc agc ttt aga tat tgg gag cat tcg ggc atc gca acc cga 1027 Arg Ile Ser Ser Phe Arg Tyr Trp Glu His Ser Gly Ile Ala Thr Arg 295 300 305 ggt gga gtg ctc agt gat agg gag ttc agc atg tgg tcc cac tgg att 1075 Gly Gly Val Leu Ser Asp Arg Glu Phe Ser Met Trp Ser His Trp Ile 310 315 320 325 gac cgc caa tac gac gtc ccc gat atc aat cca gca agt att tac acc 1123 Asp Arg Gln Tyr Asp Val Pro Asp Ile Asn Pro Ala Ser Ile Tyr Thr 330 335 340 aac caa ttc aac cca tac cga aaa gta aac ccc tcg cca taaaaggcaa 1172 Asn Gln Phe Asn Pro Tyr Arg Lys Val Asn Pro Ser Pro 345 350 gggggtcggc gttgaaattt 1192 <210> 116 <211> 354 <212> PRT <213> Corynebacterium glutamicum <400> 116 Val Arg Tyr Ile Ala Leu Ala Lys Val Thr Ser Met His Gln Arg Ser 1 5 10 15 Met Ser Phe Thr Phe Ile Arg Thr Phe Phe Val Leu Phe Gly Ile Thr 20 25 30 Leu Leu Val Ser Cys Val Pro Glu Pro Pro Asp Ser Tyr Thr Lys Glu 35 40 45 Ser Thr Val Leu Arg Tyr Gln Val Ser Asp Phe Asn Leu Asn Phe Val 50 55 60 Glu Leu Ala Val Ala Leu Gly Tyr Leu Asn Asn Ile Glu Leu Gln Val 65 70 75 80 Val Gly Ser Val Gln Gly Gly Val Glu Ser Ile Glu Ser Leu Lys Lys 85 90 95 Asp Asp Ile Asp Phe Ala Ala Val Pro Phe Ile Gly Leu Val Ala Gly 100 105 110 Glu Ile Ala Thr Gly Ala Pro Ile Lys Ala Val Ala Ala Ser Tyr Gly 115 120 125 Ile Ser His Asp Ser Ser Ser Ala Leu Leu Val Leu Lys Asp Ser Glu 130 135 140 Ile His Glu Val His Asp Leu Ile Gly Lys Thr Val Gly Ile Asn Thr 145 150 155 160 Leu Gly Ala Leu Gly Ser Ala Met Val Glu Arg His Leu Phe Asp Ala 165 170 175 Gly Leu Thr Glu Pro Glu Ile Val Ser Val Thr Gln Arg Ala Leu Pro 180 185 190 Gly Glu Tyr Leu Glu Gln Arg Leu Tyr Gln Gly Gln Val Asp Ala Ile 195 200 205 Trp Val Thr Asp Ser Ala Lys His Gln Ala Leu Glu Thr Gly Asp Phe 210 215 220 Arg Ile Leu Ala Glu Asp Ser Asp Leu Val Gln Glu Leu Asn Thr Gly 225 230 235 240 Cys Met Val Val Ser Gln Lys Leu Ile Asp Glu His Pro Ala Val Val 245 250 255 Gly Glu Leu Val Asp Gly Val Ala Gln Ala Ile Glu Phe Glu Arg Ser 260 265 270 His Ser Pro Glu Glu Val Arg Glu Val Tyr Phe Asn Tyr Leu Glu Ala 275 280 285 His Gly Gln Ser Asp Arg Ile Ser Ser Phe Arg Tyr Trp Glu His Ser 290 295 300 Gly Ile Ala Thr Arg Gly Gly Val Leu Ser Asp Arg Glu Phe Ser Met 305 310 315 320 Trp Ser His Trp Ile Asp Arg Gln Tyr Asp Val Pro Asp Ile Asn Pro 325 330 335 Ala Ser Ile Tyr Thr Asn Gln Phe Asn Pro Tyr Arg Lys Val Asn Pro 340 345 350 Ser Pro <210> 117 <211> 1996 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1966) <223> RXA01129 <400> 117 caatataacg cactttaaca tatttccccc catctttttg ttctcaaatt tatttgtact 60 cgaatgcagg atttcgagac aatgaggcag tttttctttt atg gtt aat ctc atg 115 Met Val Asn Leu Met 1 5 tcg gtc gaa ctc gaa gaa atc cgc gat ttc tta gca gga ttt gaa cct 163 Ser Val Glu Leu Glu Glu Ile Arg Asp Phe Leu Ala Gly Phe Glu Pro 10 15 20 ttc gcg cag cta cca gcc gag gaa cta gat cag tta cct gga aaa atg 211 Phe Ala Gln Leu Pro Ala Glu Glu Leu Asp Gln Leu Pro Gly Lys Met 25 30 35 agc ttg cgc tat ttt cgg cgt ggg gaa gag atc atc cca att ggt gtg 259 Ser Leu Arg Tyr Phe Arg Arg Gly Glu Glu Ile Ile Pro Ile Gly Val 40 45 50 ccc aat cat tac atg ggg gta atc aga tcg ggt gcc att gat gtt ctt 307 Pro Asn His Tyr Met Gly Val Ile Arg Ser Gly Ala Ile Asp Val Leu 55 60 65 gat cag gag ggc gta ctg ctg gat cgc cgt gac gcg ggg cgc tcg ttt 355 Asp Gln Glu Gly Val Leu Leu Asp Arg Arg Asp Ala Gly Arg Ser Phe 70 75 80 85 ggc tat tcc acg atg ggg cca gaa cga aat tct cgg tac cgt atg gtt 403 Gly Tyr Ser Thr Met Gly Pro Glu Arg Asn Ser Arg Tyr Arg Met Val 90 95 100 gcc gtg gaa gat tcc ttg gtg ttg cgt ctg ggg cgt gat gat ttt gat 451 Ala Val Glu Asp Ser Leu Val Leu Arg Leu Gly Arg Asp Asp Phe Asp 105 110 115 gag tta gcc aag cgc aac cct gat ctg aac cgt tac tac tcc agc tgg 499 Glu Leu Ala Lys Arg Asn Pro Asp Leu Asn Arg Tyr Tyr Ser Ser Trp 120 125 130 tcg aag cgt atc cgc gcc gct gct gat caa ttg cgc caa gaa tct agt 547 Ser Lys Arg Ile Arg Ala Ala Ala Asp Gln Leu Arg Gln Glu Ser Ser 135 140 145 tcg aag gtg ctg cgc acg aag ttg ggg gag ttc aag atc gcc aac ccg 595 Ser Lys Val Leu Arg Thr Lys Leu Gly Glu Phe Lys Ile Ala Asn Pro 150 155 160 165 att tcc tgc agc ccg gac acc acg atc atg gat gct gcc atc aag atg 643 Ile Ser Cys Ser Pro Asp Thr Thr Ile Met Asp Ala Ala Ile Lys Met 170 175 180 gat gag ttc ggg gtg tct tcg ttg ctg gtg cag atc gat ggg gaa ctc 691 Asp Glu Phe Gly Val Ser Ser Leu Leu Val Gln Ile Asp Gly Glu Leu 185 190 195 aaa ggc atc atc acc gat cgc gat atg cgc agc agg gtg gtg gcg aag 739 Lys Gly Ile Ile Thr Asp Arg Asp Met Arg Ser Arg Val Val Ala Lys 200 205 210 gat ttg gat att cag ctg ccg gtc tct gag gtc atg acg gtg gat ccg 787 Asp Leu Asp Ile Gln Leu Pro Val Ser Glu Val Met Thr Val Asp Pro 215 220 225 cgt tgc gcg acc tcg cag ggg ttg gct ttt gag gcc atg ttg ttg atg 835 Arg Cys Ala Thr Ser Gln Gly Leu Ala Phe Glu Ala Met Leu Leu Met 230 235 240 245 tcg gag ctg cgc att cac cac ttg ccg att gtg gat gat ggc caa atc 883 Ser Glu Leu Arg Ile His His Leu Pro Ile Val Asp Asp Gly Gln Ile 250 255 260 tcc ggc atc gtc act gca gct gac atc atg cgc ttg ctg cgc cac gat 931 Ser Gly Ile Val Thr Ala Ala Asp Ile Met Arg Leu Leu Arg His Asp 265 270 275 ccg att tac ctc act gcg gat ctg tcg cga aaa aat acc gtg gag gaa 979 Pro Ile Tyr Leu Thr Ala Asp Leu Ser Arg Lys Asn Thr Val Glu Glu 280 285 290 ttg gcc aac acc ttc cag tcg gca gcg gag gtg gct tcg aga ttt att 1027 Leu Ala Asn Thr Phe Gln Ser Ala Ala Glu Val Ala Ser Arg Phe Ile 295 300 305 gat cgg gga gct tct gcg gaa gaa gtc agt agc ttg ctc acc gtg gct 1075 Asp Arg Gly Ala Ser Ala Glu Glu Val Ser Ser Leu Leu Thr Val Ala 310 315 320 325 gcg gat tct ttg gca aga agg ctc ctt gtg ctg gcg gag cgg aaa ttt 1123 Ala Asp Ser Leu Ala Arg Arg Leu Leu Val Leu Ala Glu Arg Lys Phe 330 335 340 ggt gca ccg cca gtt ccg tat tgc ttt gtg gtg gtg ggc tcg cag ggc 1171 Gly Ala Pro Pro Val Pro Tyr Cys Phe Val Val Val Gly Ser Gln Gly 345 350 355 agg aaa gaa atg gga ctg gcc tct gat caa gac aat gcc ctt gtt ctg 1219 Arg Lys Glu Met Gly Leu Ala Ser Asp Gln Asp Asn Ala Leu Val Leu 360 365 370 gac aat tcc tac aat gac cgc gag cat gga cag tat ttt gca gcg ctg 1267 Asp Asn Ser Tyr Asn Asp Arg Glu His Gly Gln Tyr Phe Ala Ala Leu 375 380 385 agt gaa ttc gtg tgc cag ggc ctc gac cgc gca gga cag gtg ctg tgt 1315 Ser Glu Phe Val Cys Gln Gly Leu Asp Arg Ala Gly Gln Val Leu Cys 390 395 400 405 ccg ggt gac atg atg gca tcc aat ccg gag tgg cgg aaa act gct gac 1363 Pro Gly Asp Met Met Ala Ser Asn Pro Glu Trp Arg Lys Thr Ala Asp 410 415 420 cag tgg atc tcc acc ttc cat tcc tgg att act gcg ccg gag ccg gat 1411 Gln Trp Ile Ser Thr Phe His Ser Trp Ile Thr Ala Pro Glu Pro Asp 425 430 435 gcg ttg ctg cat gcc cag aca ttc ttt gat ttc agg gga att tac ggc 1459 Ala Leu Leu His Ala Gln Thr Phe Phe Asp Phe Arg Gly Ile Tyr Gly 440 445 450 gac acc gag atg gct aag gat gtc cac caa aat gcg gtg aat atg gcc 1507 Asp Thr Glu Met Ala Lys Asp Val His Gln Asn Ala Val Asn Met Ala 455 460 465 agg ggt gcg cgt cgc atg cat gca cac ttg gct agt ctt gcg gcc cgg 1555 Arg Gly Ala Arg Arg Met His Ala His Leu Ala Ser Leu Ala Ala Arg 470 475 480 485 cgc gat cct ccg ctg ggg ttt ttc cgt ggt ctt gtg gtg gag cgt tct 1603 Arg Asp Pro Pro Leu Gly Phe Phe Arg Gly Leu Val Val Glu Arg Ser 490 495 500 ggt gaa tac ggc gcg acg atg gat att aag aag ggt ggc acc gcg ggc 1651 Gly Glu Tyr Gly Ala Thr Met Asp Ile Lys Lys Gly Gly Thr Ala Gly 505 510 515 atc gtg cag atg gcg agg ctg tat gcg ctg gcc acg ggt agt gat gcg 1699 Ile Val Gln Met Ala Arg Leu Tyr Ala Leu Ala Thr Gly Ser Asp Ala 520 525 530 att ggg act cgg gag cgg ttg att gct gcg tcg ggc cat ggt cag gtg 1747 Ile Gly Thr Arg Glu Arg Leu Ile Ala Ala Ser Gly His Gly Gln Val 535 540 545 tcg cgt aag ggt gcg cag gat ttg ttg gat gcc ttt gat ttc tta gcg 1795 Ser Arg Lys Gly Ala Gln Asp Leu Leu Asp Ala Phe Asp Phe Leu Ala 550 555 560 565 gcg atg gcg ttc cag cac cag gcg cgg ttg atc aag gtg ggg gag aag 1843 Ala Met Ala Phe Gln His Gln Ala Arg Leu Ile Lys Val Gly Glu Lys 570 575 580 ccg aac tat cac att gat ccc aag acg ttg ggc aag atg gat cgg gag 1891 Pro Asn Tyr His Ile Asp Pro Lys Thr Leu Gly Lys Met Asp Arg Glu 585 590 595 cat ttg cgc gat gca ttt tcc att att aaa gat atg cag tcg gcg tta 1939 His Leu Arg Asp Ala Phe Ser Ile Ile Lys Asp Met Gln Ser Ala Leu 600 605 610 gct act aaa tat ccg gtg agg aac atc tagtgttggg gcgtcgaaaa 1986 Ala Thr Lys Tyr Pro Val Arg Asn Ile 615 620 gcgaaaatac 1996 <210> 118 <211> 622 <212> PRT <213> Corynebacterium glutamicum <400> 118 Met Val Asn Leu Met Ser Val Glu Leu Glu Glu Ile Arg Asp Phe Leu 1 5 10 15 Ala Gly Phe Glu Pro Phe Ala Gln Leu Pro Ala Glu Glu Leu Asp Gln 20 25 30 Leu Pro Gly Lys Met Ser Leu Arg Tyr Phe Arg Arg Gly Glu Glu Ile 35 40 45 Ile Pro Ile Gly Val Pro Asn His Tyr Met Gly Val Ile Arg Ser Gly 50 55 60 Ala Ile Asp Val Leu Asp Gln Glu Gly Val Leu Leu Asp Arg Arg Asp 65 70 75 80 Ala Gly Arg Ser Phe Gly Tyr Ser Thr Met Gly Pro Glu Arg Asn Ser 85 90 95 Arg Tyr Arg Met Val Ala Val Glu Asp Ser Leu Val Leu Arg Leu Gly 100 105 110 Arg Asp Asp Phe Asp Glu Leu Ala Lys Arg Asn Pro Asp Leu Asn Arg 115 120 125 Tyr Tyr Ser Ser Trp Ser Lys Arg Ile Arg Ala Ala Ala Asp Gln Leu 130 135 140 Arg Gln Glu Ser Ser Ser Lys Val Leu Arg Thr Lys Leu Gly Glu Phe 145 150 155 160 Lys Ile Ala Asn Pro Ile Ser Cys Ser Pro Asp Thr Thr Ile Met Asp 165 170 175 Ala Ala Ile Lys Met Asp Glu Phe Gly Val Ser Ser Leu Leu Val Gln 180 185 190 Ile Asp Gly Glu Leu Lys Gly Ile Ile Thr Asp Arg Asp Met Arg Ser 195 200 205 Arg Val Val Ala Lys Asp Leu Asp Ile Gln Leu Pro Val Ser Glu Val 210 215 220 Met Thr Val Asp Pro Arg Cys Ala Thr Ser Gln Gly Leu Ala Phe Glu 225 230 235 240 Ala Met Leu Leu Met Ser Glu Leu Arg Ile His His Leu Pro Ile Val 245 250 255 Asp Asp Gly Gln Ile Ser Gly Ile Val Thr Ala Ala Asp Ile Met Arg 260 265 270 Leu Leu Arg His Asp Pro Ile Tyr Leu Thr Ala Asp Leu Ser Arg Lys 275 280 285 Asn Thr Val Glu Glu Leu Ala Asn Thr Phe Gln Ser Ala Ala Glu Val 290 295 300 Ala Ser Arg Phe Ile Asp Arg Gly Ala Ser Ala Glu Glu Val Ser Ser 305 310 315 320 Leu Leu Thr Val Ala Ala Asp Ser Leu Ala Arg Arg Leu Leu Val Leu 325 330 335 Ala Glu Arg Lys Phe Gly Ala Pro Pro Val Pro Tyr Cys Phe Val Val 340 345 350 Val Gly Ser Gln Gly Arg Lys Glu Met Gly Leu Ala Ser Asp Gln Asp 355 360 365 Asn Ala Leu Val Leu Asp Asn Ser Tyr Asn Asp Arg Glu His Gly Gln 370 375 380 Tyr Phe Ala Ala Leu Ser Glu Phe Val Cys Gln Gly Leu Asp Arg Ala 385 390 395 400 Gly Gln Val Leu Cys Pro Gly Asp Met Met Ala Ser Asn Pro Glu Trp 405 410 415 Arg Lys Thr Ala Asp Gln Trp Ile Ser Thr Phe His Ser Trp Ile Thr 420 425 430 Ala Pro Glu Pro Asp Ala Leu Leu His Ala Gln Thr Phe Phe Asp Phe 435 440 445 Arg Gly Ile Tyr Gly Asp Thr Glu Met Ala Lys Asp Val His Gln Asn 450 455 460 Ala Val Asn Met Ala Arg Gly Ala Arg Arg Met His Ala His Leu Ala 465 470 475 480 Ser Leu Ala Ala Arg Arg Asp Pro Pro Leu Gly Phe Phe Arg Gly Leu 485 490 495 Val Val Glu Arg Ser Gly Glu Tyr Gly Ala Thr Met Asp Ile Lys Lys 500 505 510 Gly Gly Thr Ala Gly Ile Val Gln Met Ala Arg Leu Tyr Ala Leu Ala 515 520 525 Thr Gly Ser Asp Ala Ile Gly Thr Arg Glu Arg Leu Ile Ala Ala Ser 530 535 540 Gly His Gly Gln Val Ser Arg Lys Gly Ala Gln Asp Leu Leu Asp Ala 545 550 555 560 Phe Asp Phe Leu Ala Ala Met Ala Phe Gln His Gln Ala Arg Leu Ile 565 570 575 Lys Val Gly Glu Lys Pro Asn Tyr His Ile Asp Pro Lys Thr Leu Gly 580 585 590 Lys Met Asp Arg Glu His Leu Arg Asp Ala Phe Ser Ile Ile Lys Asp 595 600 605 Met Gln Ser Ala Leu Ala Thr Lys Tyr Pro Val Arg Asn Ile 610 615 620 <210> 119 <211> 745 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(715) <223> RXA01173 <400> 119 agatctgttt ctatgtatta aagatcacac cgagtggtgg aatttcctca agtgatttac 60 ccacaatgga ctttgttgat acccaattcg agaaaggcca atg cac gtg agc act 115 Met His Val Ser Thr 1 5 ctt cca aac aag aaa ctg cgt act cgc att ttc gca ggc acc gct gcc 163 Leu Pro Asn Lys Lys Leu Arg Thr Arg Ile Phe Ala Gly Thr Ala Ala 10 15 20 gtc gca ctg tca ctt ggt gtt gcg tct tgc tca aac gca gaa gat gct 211 Val Ala Leu Ser Leu Gly Val Ala Ser Cys Ser Asn Ala Glu Asp Ala 25 30 35 gtg gat agc gca aca gat gct gcc aac tct gca acc tcc gcc gcg gga 259 Val Asp Ser Ala Thr Asp Ala Ala Asn Ser Ala Thr Ser Ala Ala Gly 40 45 50 tct gca att aac gat gcc acc ggc act tcc agc gca tcc acc aca gag 307 Ser Ala Ile Asn Asp Ala Thr Gly Thr Ser Ser Ala Ser Thr Thr Glu 55 60 65 cct tcc gga acc tct gga tcc gac tcc ggg tct gac tct gct gga gga 355 Pro Ser Gly Thr Ser Gly Ser Asp Ser Gly Ser Asp Ser Ala Gly Gly 70 75 80 85 gac acc act gaa gta gaa agc gcc gat ggg tcc acc atc agc atc cca 403 Asp Thr Thr Glu Val Glu Ser Ala Asp Gly Ser Thr Ile Ser Ile Pro 90 95 100 act gcc gtc gtc acc gct gca aat gct gca gga ttc agt acc ccg gaa 451 Thr Ala Val Val Thr Ala Ala Asn Ala Ala Gly Phe Ser Thr Pro Glu 105 110 115 tcc gtg gaa gaa ggc ccg aat ggt gag tca ttg gtg acg ttc cct gaa 499 Ser Val Glu Glu Gly Pro Asn Gly Glu Ser Leu Val Thr Phe Pro Glu 120 125 130 ggc tac att gtt aac tct gca gaa ggt ggt gca caa gca ctg gtc ggc 547 Gly Tyr Ile Val Asn Ser Ala Glu Gly Gly Ala Gln Ala Leu Val Gly 135 140 145 atg atc ggt gaa acc tgg atc ggc gaa ggc gga cta tcc gcg gca gtg 595 Met Ile Gly Glu Thr Trp Ile Gly Glu Gly Gly Leu Ser Ala Ala Val 150 155 160 165 ggt ctc cca act ggg cct gaa gaa gca aca aca aat ggt tgg act caa 643 Gly Leu Pro Thr Gly Pro Glu Glu Ala Thr Thr Asn Gly Trp Thr Gln 170 175 180 cag ttc aca tct gga gta att agc tgg ctt gat gat gga tca gga cag 691 Gln Phe Thr Ser Gly Val Ile Ser Trp Leu Asp Asp Gly Ser Gly Gln 185 190 195 ttc gca gct tct gtt gaa cct gct taagggaatc tcacctggcc tcctttggca 745 Phe Ala Ala Ser Val Glu Pro Ala 200 205 <210> 120 <211> 205 <212> PRT <213> Corynebacterium glutamicum <400> 120 Met His Val Ser Thr Leu Pro Asn Lys Lys Leu Arg Thr Arg Ile Phe 1 5 10 15 Ala Gly Thr Ala Ala Val Ala Leu Ser Leu Gly Val Ala Ser Cys Ser 20 25 30 Asn Ala Glu Asp Ala Val Asp Ser Ala Thr Asp Ala Ala Asn Ser Ala 35 40 45 Thr Ser Ala Ala Gly Ser Ala Ile Asn Asp Ala Thr Gly Thr Ser Ser 50 55 60 Ala Ser Thr Thr Glu Pro Ser Gly Thr Ser Gly Ser Asp Ser Gly Ser 65 70 75 80 Asp Ser Ala Gly Gly Asp Thr Thr Glu Val Glu Ser Ala Asp Gly Ser 85 90 95 Thr Ile Ser Ile Pro Thr Ala Val Val Thr Ala Ala Asn Ala Ala Gly 100 105 110 Phe Ser Thr Pro Glu Ser Val Glu Glu Gly Pro Asn Gly Glu Ser Leu 115 120 125 Val Thr Phe Pro Glu Gly Tyr Ile Val Asn Ser Ala Glu Gly Gly Ala 130 135 140 Gln Ala Leu Val Gly Met Ile Gly Glu Thr Trp Ile Gly Glu Gly Gly 145 150 155 160 Leu Ser Ala Ala Val Gly Leu Pro Thr Gly Pro Glu Glu Ala Thr Thr 165 170 175 Asn Gly Trp Thr Gln Gln Phe Thr Ser Gly Val Ile Ser Trp Leu Asp 180 185 190 Asp Gly Ser Gly Gln Phe Ala Ala Ser Val Glu Pro Ala 195 200 205 <210> 121 <211> 880 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(850) <223> RXA01174 <400> 121 atatcgcaac cgctgttaat gaagaggaag aggctcgcga tatcgcgaag ctgtgccagg 60 agatggtgga attagctcgg aatattgaga agttgaggta atg agc aac atg cag 115 Met Ser Asn Met Gln 1 5 gga aac gat tcc aag aaa tct agc ggc gcg agt cgt gcg gag agc cca 163 Gly Asn Asp Ser Lys Lys Ser Ser Gly Ala Ser Arg Ala Glu Ser Pro 10 15 20 ctg atc aag ttc cgg aca ttg att atc gtc atc ttt gtc atc ttg atc 211 Leu Ile Lys Phe Arg Thr Leu Ile Ile Val Ile Phe Val Ile Leu Ile 25 30 35 gtt ggt ttg gca tct att gca gtg gga cct gtc gtg tac cag ctc atc 259 Val Gly Leu Ala Ser Ile Ala Val Gly Pro Val Val Tyr Gln Leu Ile 40 45 50 atg gga cct ggt gtg aaa acc gaa gga atc cag gct gat ggc gca gca 307 Met Gly Pro Gly Val Lys Thr Glu Gly Ile Gln Ala Asp Gly Ala Ala 55 60 65 cct gcg tcc acc gac atg aac ggc acc tgg gat gtt gcc cca ggg agt 355 Pro Ala Ser Thr Asp Met Asn Gly Thr Trp Asp Val Ala Pro Gly Ser 70 75 80 85 att cca aac acc acc tca gct gga ttc acc ttc gct gag atc ctg cca 403 Ile Pro Asn Thr Thr Ser Ala Gly Phe Thr Phe Ala Glu Ile Leu Pro 90 95 100 ggc gaa gaa aag atc acc tcc ggc tca acc act ggt gtc act ggc gaa 451 Gly Glu Glu Lys Ile Thr Ser Gly Ser Thr Thr Gly Val Thr Gly Glu 105 110 115 gtg gtc atc gag gat aac tcc ctg atc tct ggt ctg att acc gtc aac 499 Val Val Ile Glu Asp Asn Ser Leu Ile Ser Gly Leu Ile Thr Val Asn 120 125 130 atg act cac atc acc acc gat cag gaa aag cgc gac atc aac gtg cgc 547 Met Thr His Ile Thr Thr Asp Gln Glu Lys Arg Asp Ile Asn Val Arg 135 140 145 act aag ctc ttc cac acc gat cag tac cca gaa gca acc ttt gag gtt 595 Thr Lys Leu Phe His Thr Asp Gln Tyr Pro Glu Ala Thr Phe Glu Val 150 155 160 165 acc gat tcc gtt gat ctt tct gcg ctc cca gac acc gga tcc att gct 643 Thr Asp Ser Val Asp Leu Ser Ala Leu Pro Asp Thr Gly Ser Ile Ala 170 175 180 cag gtt gtc atc cca ggc gag ttg acc atc cac ggt gaa acc aag gct 691 Gln Val Val Ile Pro Gly Glu Leu Thr Ile His Gly Glu Thr Lys Ala 185 190 195 gtg gag cct acc ttt gat gta ctt cgt act ggt gac caa gtt atc gtg 739 Val Glu Pro Thr Phe Asp Val Leu Arg Thr Gly Asp Gln Val Ile Val 200 205 210 gct tcc gat atc gaa atc aac cgc ctc gac ttc ggt gta gaa acc cca 787 Ala Ser Asp Ile Glu Ile Asn Arg Leu Asp Phe Gly Val Glu Thr Pro 215 220 225 gag ttc atc gcc gca aag atc aat gag acc ggc gag atc aac gtc cga 835 Glu Phe Ile Ala Ala Lys Ile Asn Glu Thr Gly Glu Ile Asn Val Arg 230 235 240 245 atc gta ttg gag aaa taaaccatga tggcatcacg gatgatccca 880 Ile Val Leu Glu Lys 250 <210> 122 <211> 250 <212> PRT <213> Corynebacterium glutamicum <400> 122 Met Ser Asn Met Gln Gly Asn Asp Ser Lys Lys Ser Ser Gly Ala Ser 1 5 10 15 Arg Ala Glu Ser Pro Leu Ile Lys Phe Arg Thr Leu Ile Ile Val Ile 20 25 30 Phe Val Ile Leu Ile Val Gly Leu Ala Ser Ile Ala Val Gly Pro Val 35 40 45 Val Tyr Gln Leu Ile Met Gly Pro Gly Val Lys Thr Glu Gly Ile Gln 50 55 60 Ala Asp Gly Ala Ala Pro Ala Ser Thr Asp Met Asn Gly Thr Trp Asp 65 70 75 80 Val Ala Pro Gly Ser Ile Pro Asn Thr Thr Ser Ala Gly Phe Thr Phe 85 90 95 Ala Glu Ile Leu Pro Gly Glu Glu Lys Ile Thr Ser Gly Ser Thr Thr 100 105 110 Gly Val Thr Gly Glu Val Val Ile Glu Asp Asn Ser Leu Ile Ser Gly 115 120 125 Leu Ile Thr Val Asn Met Thr His Ile Thr Thr Asp Gln Glu Lys Arg 130 135 140 Asp Ile Asn Val Arg Thr Lys Leu Phe His Thr Asp Gln Tyr Pro Glu 145 150 155 160 Ala Thr Phe Glu Val Thr Asp Ser Val Asp Leu Ser Ala Leu Pro Asp 165 170 175 Thr Gly Ser Ile Ala Gln Val Val Ile Pro Gly Glu Leu Thr Ile His 180 185 190 Gly Glu Thr Lys Ala Val Glu Pro Thr Phe Asp Val Leu Arg Thr Gly 195 200 205 Asp Gln Val Ile Val Ala Ser Asp Ile Glu Ile Asn Arg Leu Asp Phe 210 215 220 Gly Val Glu Thr Pro Glu Phe Ile Ala Ala Lys Ile Asn Glu Thr Gly 225 230 235 240 Glu Ile Asn Val Arg Ile Val Leu Glu Lys 245 250 <210> 123 <211> 1675 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1645) <223> RXA01184 <400> 123 atcttggttg ggtgcgtccg aaggccatag cgaaggccaa aatcagaacg aggatcgggc 60 tgagtaaatg actaaaacac ttctgaaact acagctgacg ttg tgg gga aga act 115 Leu Trp Gly Arg Thr 1 5 att aaa gga aat aaa gcg gca ata gtg atg atg tcg ctg ata tct ttt 163 Ile Lys Gly Asn Lys Ala Ala Ile Val Met Met Ser Leu Ile Ser Phe 10 15 20 tac gcc ttg atg ggt ttg ttt ggt ttc ggc atc ttt ttg gct ctt ggg 211 Tyr Ala Leu Met Gly Leu Phe Gly Phe Gly Ile Phe Leu Ala Leu Gly 25 30 35 ctt ggg caa gac cac atg ggc atc ctt gct ggt gtt gtc tcg gtc ggc 259 Leu Gly Gln Asp His Met Gly Ile Leu Ala Gly Val Val Ser Val Gly 40 45 50 atg gtg gct tat tgc att gct gcg ttt atg tgg ccg tca ggt gag ggg 307 Met Val Ala Tyr Cys Ile Ala Ala Phe Met Trp Pro Ser Gly Glu Gly 55 60 65 cag ctg gat ccg act gca ttt tcc acc atg ccg cta tcg gcg aag caa 355 Gln Leu Asp Pro Thr Ala Phe Ser Thr Met Pro Leu Ser Ala Lys Gln 70 75 80 85 tta ttg cct gga ttc gct atc ggt acg ctc ctg cag tca cgg ggg att 403 Leu Leu Pro Gly Phe Ala Ile Gly Thr Leu Leu Gln Ser Arg Gly Ile 90 95 100 att gcg gtg att tgt acg gtg gcg aca tcc att att gct gcg gtg ttt 451 Ile Ala Val Ile Cys Thr Val Ala Thr Ser Ile Ile Ala Ala Val Phe 105 110 115 tta cct gtt ggt tcg tgg ccg atg atc gtg ttc atg atg gcg gta tcg 499 Leu Pro Val Gly Ser Trp Pro Met Ile Val Phe Met Met Ala Val Ser 120 125 130 ctg gtt act acg ttg ctt ttg ggt gag ttg ctt ggg gcg ttg acc tcg 547 Leu Val Thr Thr Leu Leu Leu Gly Glu Leu Leu Gly Ala Leu Thr Ser 135 140 145 ggt tct tct tct agg gtg agt aat gat cgc cgt aca gtt ctt act tcc 595 Gly Ser Ser Ser Arg Val Ser Asn Asp Arg Arg Thr Val Leu Thr Ser 150 155 160 165 gtt gtc ttc atg gtg ttt gtt gtt ggc tat aac atg ctg att ggc gcg 643 Val Val Phe Met Val Phe Val Val Gly Tyr Asn Met Leu Ile Gly Ala 170 175 180 gat gga atg agt cga atc gat gcc att ggg gct tat aca aag tgg aca 691 Asp Gly Met Ser Arg Ile Asp Ala Ile Gly Ala Tyr Thr Lys Trp Thr 185 190 195 cca ttt ggg gcg ggt gca ggt gct att gag gct ttt gct gtt ggt ttg 739 Pro Phe Gly Ala Gly Ala Gly Ala Ile Glu Ala Phe Ala Val Gly Leu 200 205 210 tgg ggt gag gca ggc ctg tta aca ttg ctg gct ttt gtt tat gtt gct 787 Trp Gly Glu Ala Gly Leu Leu Thr Leu Leu Ala Phe Val Tyr Val Ala 215 220 225 gct ggt ttc tgg tta tgg tca cag ctg att aat cgc gcg ctc act gcg 835 Ala Gly Phe Trp Leu Trp Ser Gln Leu Ile Asn Arg Ala Leu Thr Ala 230 235 240 245 ccg ctg gac caa ggt ggg caa ggg caa agc gct aaa gac agc gcc ggt 883 Pro Leu Asp Gln Gly Gly Gln Gly Gln Ser Ala Lys Asp Ser Ala Gly 250 255 260 gaa ggc aag aag gtt ctc ttt ctg cca ggt att cct tgg tca gtt gga 931 Glu Gly Lys Lys Val Leu Phe Leu Pro Gly Ile Pro Trp Ser Val Gly 265 270 275 ggt gcc att ttc tcg agg tcg ctg cgt tat atg ttc agg gac tcc agg 979 Gly Ala Ile Phe Ser Arg Ser Leu Arg Tyr Met Phe Arg Asp Ser Arg 280 285 290 ttg ttg gga tca atg att gtg ttc ccg ctt ctt ggc gtg ctg ttt att 1027 Leu Leu Gly Ser Met Ile Val Phe Pro Leu Leu Gly Val Leu Phe Ile 295 300 305 ttc cag agc ttc acc gtt gag ttt ttc atg atc tat gtt ggg ttg atc 1075 Phe Gln Ser Phe Thr Val Glu Phe Phe Met Ile Tyr Val Gly Leu Ile 310 315 320 325 atg atg gca gtg ttc gca gga tcc gtt gct acc aat gat ttt ggc tat 1123 Met Met Ala Val Phe Ala Gly Ser Val Ala Thr Asn Asp Phe Gly Tyr 330 335 340 gac ggc cct tcg ttg tgg cta aat atc gtt gct ggt gtc aaa gcc cga 1171 Asp Gly Pro Ser Leu Trp Leu Asn Ile Val Ala Gly Val Lys Ala Arg 345 350 355 acg ttg ttg atg ccc agg cac tgg gca tca atg ctg ccg gga agt gtg 1219 Thr Leu Leu Met Pro Arg His Trp Ala Ser Met Leu Pro Gly Ser Val 360 365 370 tca att gtg gtg ttt atg atc atc acc att gtg ctc gcg gag aat aag 1267 Ser Ile Val Val Phe Met Ile Ile Thr Ile Val Leu Ala Glu Asn Lys 375 380 385 acc acc gct gtg ctg atc tgt ttt att ggc ctg ggg atc ttt atc tcc 1315 Thr Thr Ala Val Leu Ile Cys Phe Ile Gly Leu Gly Ile Phe Ile Ser 390 395 400 405 agt gcg gct gta gcg ttg ttg gtc acc aca ttt aat ccg tat ccg act 1363 Ser Ala Ala Val Ala Leu Leu Val Thr Thr Phe Asn Pro Tyr Pro Thr 410 415 420 tct aag cca ggc acg agt cct tgg ggc gat cga agt ggc tat tcc ggt 1411 Ser Lys Pro Gly Thr Ser Pro Trp Gly Asp Arg Ser Gly Tyr Ser Gly 425 430 435 gct gcg ttc gtg gga gca ttt gcc gca ctg tta ctg gga tgg atc ccg 1459 Ala Ala Phe Val Gly Ala Phe Ala Ala Leu Leu Leu Gly Trp Ile Pro 440 445 450 acg att cct act atc gca ttg ggt atc ttt ggt ctg gtt acc gat cag 1507 Thr Ile Pro Thr Ile Ala Leu Gly Ile Phe Gly Leu Val Thr Asp Gln 455 460 465 atg tgg atg atc atc ctc gcg gag gtg ctg gcc att att ctc cca gta 1555 Met Trp Met Ile Ile Leu Ala Glu Val Leu Ala Ile Ile Leu Pro Val 470 475 480 485 gct gtg tac atc ggc gtt gct aag gtg tgt att cgc aag gtg gag aag 1603 Ala Val Tyr Ile Gly Val Ala Lys Val Cys Ile Arg Lys Val Glu Lys 490 495 500 gat ctt ccg gag atc ttc gac aag gtg aaa act cac gtg aaa 1645 Asp Leu Pro Glu Ile Phe Asp Lys Val Lys Thr His Val Lys 505 510 515 tagaaaaatg cgggtgcttc gagaaaatct 1675 <210> 124 <211> 515 <212> PRT <213> Corynebacterium glutamicum <400> 124 Leu Trp Gly Arg Thr Ile Lys Gly Asn Lys Ala Ala Ile Val Met Met 1 5 10 15 Ser Leu Ile Ser Phe Tyr Ala Leu Met Gly Leu Phe Gly Phe Gly Ile 20 25 30 Phe Leu Ala Leu Gly Leu Gly Gln Asp His Met Gly Ile Leu Ala Gly 35 40 45 Val Val Ser Val Gly Met Val Ala Tyr Cys Ile Ala Ala Phe Met Trp 50 55 60 Pro Ser Gly Glu Gly Gln Leu Asp Pro Thr Ala Phe Ser Thr Met Pro 65 70 75 80 Leu Ser Ala Lys Gln Leu Leu Pro Gly Phe Ala Ile Gly Thr Leu Leu 85 90 95 Gln Ser Arg Gly Ile Ile Ala Val Ile Cys Thr Val Ala Thr Ser Ile 100 105 110 Ile Ala Ala Val Phe Leu Pro Val Gly Ser Trp Pro Met Ile Val Phe 115 120 125 Met Met Ala Val Ser Leu Val Thr Thr Leu Leu Leu Gly Glu Leu Leu 130 135 140 Gly Ala Leu Thr Ser Gly Ser Ser Ser Arg Val Ser Asn Asp Arg Arg 145 150 155 160 Thr Val Leu Thr Ser Val Val Phe Met Val Phe Val Val Gly Tyr Asn 165 170 175 Met Leu Ile Gly Ala Asp Gly Met Ser Arg Ile Asp Ala Ile Gly Ala 180 185 190 Tyr Thr Lys Trp Thr Pro Phe Gly Ala Gly Ala Gly Ala Ile Glu Ala 195 200 205 Phe Ala Val Gly Leu Trp Gly Glu Ala Gly Leu Leu Thr Leu Leu Ala 210 215 220 Phe Val Tyr Val Ala Ala Gly Phe Trp Leu Trp Ser Gln Leu Ile Asn 225 230 235 240 Arg Ala Leu Thr Ala Pro Leu Asp Gln Gly Gly Gln Gly Gln Ser Ala 245 250 255 Lys Asp Ser Ala Gly Glu Gly Lys Lys Val Leu Phe Leu Pro Gly Ile 260 265 270 Pro Trp Ser Val Gly Gly Ala Ile Phe Ser Arg Ser Leu Arg Tyr Met 275 280 285 Phe Arg Asp Ser Arg Leu Leu Gly Ser Met Ile Val Phe Pro Leu Leu 290 295 300 Gly Val Leu Phe Ile Phe Gln Ser Phe Thr Val Glu Phe Phe Met Ile 305 310 315 320 Tyr Val Gly Leu Ile Met Met Ala Val Phe Ala Gly Ser Val Ala Thr 325 330 335 Asn Asp Phe Gly Tyr Asp Gly Pro Ser Leu Trp Leu Asn Ile Val Ala 340 345 350 Gly Val Lys Ala Arg Thr Leu Leu Met Pro Arg His Trp Ala Ser Met 355 360 365 Leu Pro Gly Ser Val Ser Ile Val Val Phe Met Ile Ile Thr Ile Val 370 375 380 Leu Ala Glu Asn Lys Thr Thr Ala Val Leu Ile Cys Phe Ile Gly Leu 385 390 395 400 Gly Ile Phe Ile Ser Ser Ala Ala Val Ala Leu Leu Val Thr Thr Phe 405 410 415 Asn Pro Tyr Pro Thr Ser Lys Pro Gly Thr Ser Pro Trp Gly Asp Arg 420 425 430 Ser Gly Tyr Ser Gly Ala Ala Phe Val Gly Ala Phe Ala Ala Leu Leu 435 440 445 Leu Gly Trp Ile Pro Thr Ile Pro Thr Ile Ala Leu Gly Ile Phe Gly 450 455 460 Leu Val Thr Asp Gln Met Trp Met Ile Ile Leu Ala Glu Val Leu Ala 465 470 475 480 Ile Ile Leu Pro Val Ala Val Tyr Ile Gly Val Ala Lys Val Cys Ile 485 490 495 Arg Lys Val Glu Lys Asp Leu Pro Glu Ile Phe Asp Lys Val Lys Thr 500 505 510 His Val Lys 515 <210> 125 <211> 820 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(790) <223> RXA01196 <400> 125 gggcggagca ttcattgaat ccacgtgatt tcaaccgctt tcgagccagc aaagacaccc 60 gcaaaaaccg ctaagtagac gtcattgtta tggtgggtgc atg cgt tta gtc atc 115 Met Arg Leu Val Ile 1 5 gcc cgt tgc tca gtt gat tat gtt ggc cgt ttg gaa gct cat ctt ccg 163 Ala Arg Cys Ser Val Asp Tyr Val Gly Arg Leu Glu Ala His Leu Pro 10 15 20 tcc gcc gat cgc ctt ttg atg gtt aag gcg gat ggt tct gta tcc atc 211 Ser Ala Asp Arg Leu Leu Met Val Lys Ala Asp Gly Ser Val Ser Ile 25 30 35 cat gcc gat gac cgt gcc tat aag cca ctg aac tgg atg aca cct cca 259 His Ala Asp Asp Arg Ala Tyr Lys Pro Leu Asn Trp Met Thr Pro Pro 40 45 50 tgt tct tta gtt gaa act ccc atc act gat gaa gat ggt gaa gca aca 307 Cys Ser Leu Val Glu Thr Pro Ile Thr Asp Glu Asp Gly Glu Ala Thr 55 60 65 ggg gaa agc ctg tgg gtg gtg gaa aac aaa aag ggc gag cag ctt cga 355 Gly Glu Ser Leu Trp Val Val Glu Asn Lys Lys Gly Glu Gln Leu Arg 70 75 80 85 att act gtg gaa gaa att cat tcg gaa caa aac ttc gat cta ggc caa 403 Ile Thr Val Glu Glu Ile His Ser Glu Gln Asn Phe Asp Leu Gly Gln 90 95 100 gac cca ggt ttg gtg aaa gac gga gtg gaa gat cat ctc caa gag ctt 451 Asp Pro Gly Leu Val Lys Asp Gly Val Glu Asp His Leu Gln Glu Leu 105 110 115 ctt gca gag cac atc act acg ttg ggt gat ggg tac aca ttg att cgt 499 Leu Ala Glu His Ile Thr Thr Leu Gly Asp Gly Tyr Thr Leu Ile Arg 120 125 130 cgg gag tat cca aca gct att ggg cct gtc gat att ttg tgt cgc aac 547 Arg Glu Tyr Pro Thr Ala Ile Gly Pro Val Asp Ile Leu Cys Arg Asn 135 140 145 tct gac ggc gag act gtc gct gtg gag atc aag cgt cgt ggt ggc atc 595 Ser Asp Gly Glu Thr Val Ala Val Glu Ile Lys Arg Arg Gly Gly Ile 150 155 160 165 gac ggc gtt gag cag ttg acc agg tat ttg gaa ttg ctc aac cgt gat 643 Asp Gly Val Glu Gln Leu Thr Arg Tyr Leu Glu Leu Leu Asn Arg Asp 170 175 180 gaa ttg ctc aag cct gtt cat gga gtg ttt gca gcc cag gag att aag 691 Glu Leu Leu Lys Pro Val His Gly Val Phe Ala Ala Gln Glu Ile Lys 185 190 195 cct cag gca aag act ctc gcg gag gat cgt ggc atc aag tgc gtg acg 739 Pro Gln Ala Lys Thr Leu Ala Glu Asp Arg Gly Ile Lys Cys Val Thr 200 205 210 ttg gat tat caa gcg ctt cgt ggc att gag tcc aat gag ctg aca ttg 787 Leu Asp Tyr Gln Ala Leu Arg Gly Ile Glu Ser Asn Glu Leu Thr Leu 215 220 225 ttc taagaacatg ggccgaaaaa atagaagaac 820 Phe 230 <210> 126 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 126 Met Arg Leu Val Ile Ala Arg Cys Ser Val Asp Tyr Val Gly Arg Leu 1 5 10 15 Glu Ala His Leu Pro Ser Ala Asp Arg Leu Leu Met Val Lys Ala Asp 20 25 30 Gly Ser Val Ser Ile His Ala Asp Asp Arg Ala Tyr Lys Pro Leu Asn 35 40 45 Trp Met Thr Pro Pro Cys Ser Leu Val Glu Thr Pro Ile Thr Asp Glu 50 55 60 Asp Gly Glu Ala Thr Gly Glu Ser Leu Trp Val Val Glu Asn Lys Lys 65 70 75 80 Gly Glu Gln Leu Arg Ile Thr Val Glu Glu Ile His Ser Glu Gln Asn 85 90 95 Phe Asp Leu Gly Gln Asp Pro Gly Leu Val Lys Asp Gly Val Glu Asp 100 105 110 His Leu Gln Glu Leu Leu Ala Glu His Ile Thr Thr Leu Gly Asp Gly 115 120 125 Tyr Thr Leu Ile Arg Arg Glu Tyr Pro Thr Ala Ile Gly Pro Val Asp 130 135 140 Ile Leu Cys Arg Asn Ser Asp Gly Glu Thr Val Ala Val Glu Ile Lys 145 150 155 160 Arg Arg Gly Gly Ile Asp Gly Val Glu Gln Leu Thr Arg Tyr Leu Glu 165 170 175 Leu Leu Asn Arg Asp Glu Leu Leu Lys Pro Val His Gly Val Phe Ala 180 185 190 Ala Gln Glu Ile Lys Pro Gln Ala Lys Thr Leu Ala Glu Asp Arg Gly 195 200 205 Ile Lys Cys Val Thr Leu Asp Tyr Gln Ala Leu Arg Gly Ile Glu Ser 210 215 220 Asn Glu Leu Thr Leu Phe 225 230 <210> 127 <211> 1300 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1270) <223> RXA01263 <400> 127 gggaggtcgt gcggaaaaag gtgtaggtgt acttctaaaa gttaaaccta tgcgttggat 60 cggagatctt tcctattcgc tttatctata gcattggcca ttg atc gtt gta ggg 115 Leu Ile Val Val Gly 1 5 att tat tat ttc aat gga gaa atg cac ttt tgg caa ggt ctc cta att 163 Ile Tyr Tyr Phe Asn Gly Glu Met His Phe Trp Gln Gly Leu Leu Ile 10 15 20 atc ggg ttc tct ttc atc cct gct tgg cta agt tat cat ttc att gag 211 Ile Gly Phe Ser Phe Ile Pro Ala Trp Leu Ser Tyr His Phe Ile Glu 25 30 35 aat cca atg cgt aat tgg tca gca atc aag gct gac gca aga aaa gca 259 Asn Pro Met Arg Asn Trp Ser Ala Ile Lys Ala Asp Ala Arg Lys Ala 40 45 50 gtg gcc ttt gga gtt att ttg atg acg gta tcg gcg act gct ggg atc 307 Val Ala Phe Gly Val Ile Leu Met Thr Val Ser Ala Thr Ala Gly Ile 55 60 65 ctc ctc ttt tta tct cca aat aga agc caa gct gcg cca ccc caa ttt 355 Leu Leu Phe Leu Ser Pro Asn Arg Ser Gln Ala Ala Pro Pro Gln Phe 70 75 80 85 agt ttg acc ccg tat gat cca acc gct gta aat aag gag tcg gaa aaa 403 Ser Leu Thr Pro Tyr Asp Pro Thr Ala Val Asn Lys Glu Ser Glu Lys 90 95 100 gaa gca gca aag aat ctg ttt ggc gct gag gcg ttg aca gtg gat ccg 451 Glu Ala Ala Lys Asn Leu Phe Gly Ala Glu Ala Leu Thr Val Asp Pro 105 110 115 gat gcc ggt gag gtt gtt gat cga gta gat aat ttt tat ccg acg act 499 Asp Ala Gly Glu Val Val Asp Arg Val Asp Asn Phe Tyr Pro Thr Thr 120 125 130 gct aag gca aaa cga gat tac cca agt aac tat gca gcg ggt tgt cac 547 Ala Lys Ala Lys Arg Asp Tyr Pro Ser Asn Tyr Ala Ala Gly Cys His 135 140 145 caa gaa gtc aat gag act agt cct gag tca tgt gtt tat ggt gat aaa 595 Gln Glu Val Asn Glu Thr Ser Pro Glu Ser Cys Val Tyr Gly Asp Lys 150 155 160 165 aat tct gat ttt tct gta gca ctt gtc ggt gac tcc cac gct ggt cat 643 Asn Ser Asp Phe Ser Val Ala Leu Val Gly Asp Ser His Ala Gly His 170 175 180 tgg ctt cct gcc ttg gaa cca att gct gaa gca cag ggg tgg aga ttg 691 Trp Leu Pro Ala Leu Glu Pro Ile Ala Glu Ala Gln Gly Trp Arg Leu 185 190 195 gaa gtt tat aca aag tca cag tgt cca ctc ata agc act gcg atc aaa 739 Glu Val Tyr Thr Lys Ser Gln Cys Pro Leu Ile Ser Thr Ala Ile Lys 200 205 210 ctt ggt gaa act ttt tat gca gaa tgc tat gag tgg aat gaa aaa tta 787 Leu Gly Glu Thr Phe Tyr Ala Glu Cys Tyr Glu Trp Asn Glu Lys Leu 215 220 225 ctt gct aag cta act gga cct tct gca cca aat cat gtg att gta agt 835 Leu Ala Lys Leu Thr Gly Pro Ser Ala Pro Asn His Val Ile Val Ser 230 235 240 245 agc caa cgt tac gct tct gca aat ccg tta atc gat agt gtc gcg acg 883 Ser Gln Arg Tyr Ala Ser Ala Asn Pro Leu Ile Asp Ser Val Ala Thr 250 255 260 gga acc gtt tcc gaa gga tat gaa atg gca tgg aat tca tta aaa gat 931 Gly Thr Val Ser Glu Gly Tyr Glu Met Ala Trp Asn Ser Leu Lys Asp 265 270 275 gca ggt gtt tct att tct gta ctt ctt gat act cct cgg ccg caa att 979 Ala Gly Val Ser Ile Ser Val Leu Leu Asp Thr Pro Arg Pro Gln Ile 280 285 290 gat atc cca gaa tgt gta gca tca aac cgc gat aat ctc tca gaa tgt 1027 Asp Ile Pro Glu Cys Val Ala Ser Asn Arg Asp Asn Leu Ser Glu Cys 295 300 305 tca gtt cac cgg agc gtt gcg ctt ggg act gaa gct cat cct cag caa 1075 Ser Val His Arg Ser Val Ala Leu Gly Thr Glu Ala His Pro Gln Gln 310 315 320 325 aaa act gca gct caa aat ata gac gtg cct gta ttg gat ttg agt aat 1123 Lys Thr Ala Ala Gln Asn Ile Asp Val Pro Val Leu Asp Leu Ser Asn 330 335 340 tgg att tgt ccg gaa gaa tat tgc tcc gct gtt atc gga aat gtt ttg 1171 Trp Ile Cys Pro Glu Glu Tyr Cys Ser Ala Val Ile Gly Asn Val Leu 345 350 355 gta tac agg gat tca cat cat ttg acc gct acg tat gct cgt agt ctc 1219 Val Tyr Arg Asp Ser His His Leu Thr Ala Thr Tyr Ala Arg Ser Leu 360 365 370 tct agc gca tta tgg aat gag ttg gtt gcc tca aat ggt gag cct ttt 1267 Ser Ser Ala Leu Trp Asn Glu Leu Val Ala Ser Asn Gly Glu Pro Phe 375 380 385 aag taagaggtag ttgttcaagt agcgctttgt 1300 Lys 390 <210> 128 <211> 390 <212> PRT <213> Corynebacterium glutamicum <400> 128 Leu Ile Val Val Gly Ile Tyr Tyr Phe Asn Gly Glu Met His Phe Trp 1 5 10 15 Gln Gly Leu Leu Ile Ile Gly Phe Ser Phe Ile Pro Ala Trp Leu Ser 20 25 30 Tyr His Phe Ile Glu Asn Pro Met Arg Asn Trp Ser Ala Ile Lys Ala 35 40 45 Asp Ala Arg Lys Ala Val Ala Phe Gly Val Ile Leu Met Thr Val Ser 50 55 60 Ala Thr Ala Gly Ile Leu Leu Phe Leu Ser Pro Asn Arg Ser Gln Ala 65 70 75 80 Ala Pro Pro Gln Phe Ser Leu Thr Pro Tyr Asp Pro Thr Ala Val Asn 85 90 95 Lys Glu Ser Glu Lys Glu Ala Ala Lys Asn Leu Phe Gly Ala Glu Ala 100 105 110 Leu Thr Val Asp Pro Asp Ala Gly Glu Val Val Asp Arg Val Asp Asn 115 120 125 Phe Tyr Pro Thr Thr Ala Lys Ala Lys Arg Asp Tyr Pro Ser Asn Tyr 130 135 140 Ala Ala Gly Cys His Gln Glu Val Asn Glu Thr Ser Pro Glu Ser Cys 145 150 155 160 Val Tyr Gly Asp Lys Asn Ser Asp Phe Ser Val Ala Leu Val Gly Asp 165 170 175 Ser His Ala Gly His Trp Leu Pro Ala Leu Glu Pro Ile Ala Glu Ala 180 185 190 Gln Gly Trp Arg Leu Glu Val Tyr Thr Lys Ser Gln Cys Pro Leu Ile 195 200 205 Ser Thr Ala Ile Lys Leu Gly Glu Thr Phe Tyr Ala Glu Cys Tyr Glu 210 215 220 Trp Asn Glu Lys Leu Leu Ala Lys Leu Thr Gly Pro Ser Ala Pro Asn 225 230 235 240 His Val Ile Val Ser Ser Gln Arg Tyr Ala Ser Ala Asn Pro Leu Ile 245 250 255 Asp Ser Val Ala Thr Gly Thr Val Ser Glu Gly Tyr Glu Met Ala Trp 260 265 270 Asn Ser Leu Lys Asp Ala Gly Val Ser Ile Ser Val Leu Leu Asp Thr 275 280 285 Pro Arg Pro Gln Ile Asp Ile Pro Glu Cys Val Ala Ser Asn Arg Asp 290 295 300 Asn Leu Ser Glu Cys Ser Val His Arg Ser Val Ala Leu Gly Thr Glu 305 310 315 320 Ala His Pro Gln Gln Lys Thr Ala Ala Gln Asn Ile Asp Val Pro Val 325 330 335 Leu Asp Leu Ser Asn Trp Ile Cys Pro Glu Glu Tyr Cys Ser Ala Val 340 345 350 Ile Gly Asn Val Leu Val Tyr Arg Asp Ser His His Leu Thr Ala Thr 355 360 365 Tyr Ala Arg Ser Leu Ser Ser Ala Leu Trp Asn Glu Leu Val Ala Ser 370 375 380 Asn Gly Glu Pro Phe Lys 385 390 <210> 129 <211> 1246 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1216) <223> RXA01268 <400> 129 gtagtaaccg atacgattta ttgaagctat ttagtaattg aggacaggtg tgtcaatgat 60 actaagaaat aggtcacgtt gtagatcttc tagagagaat gtg att ctc ttt ggg 115 Val Ile Leu Phe Gly 1 5 gct acg aca gac atg tca aat att ttt tat gaa ggg atc ctg cag aat 163 Ala Thr Thr Asp Met Ser Asn Ile Phe Tyr Glu Gly Ile Leu Gln Asn 10 15 20 cta att caa gat ggg tgg gat gtg cac ctt gtt tca aat cca ggc cca 211 Leu Ile Gln Asp Gly Trp Asp Val His Leu Val Ser Asn Pro Gly Pro 25 30 35 gtt ggg aag aaa tta ctg aat ggt aaa gct cat act atc gag atg tct 259 Val Gly Lys Lys Leu Leu Asn Gly Lys Ala His Thr Ile Glu Met Ser 40 45 50 aga gag att tca ata ggt acc gat gtt aaa tca tta ttt aat tgg gtg 307 Arg Glu Ile Ser Ile Gly Thr Asp Val Lys Ser Leu Phe Asn Trp Val 55 60 65 cta ttg ctt agg aaa att cgt cca aga gtg ctg ata gtt gga act ccg 355 Leu Leu Leu Arg Lys Ile Arg Pro Arg Val Leu Ile Val Gly Thr Pro 70 75 80 85 aaa gct tca ttg ctg gga gtc gtg gca gca cga att gct cga gtg cca 403 Lys Ala Ser Leu Leu Gly Val Val Ala Ala Arg Ile Ala Arg Val Pro 90 95 100 cga att gtc tat gtg gca cat ggg ctg cgc tct gaa act gtt tta ggc 451 Arg Ile Val Tyr Val Ala His Gly Leu Arg Ser Glu Thr Val Leu Gly 105 110 115 tta aaa aag aag att cta gtg ttt ttg gaa tat ttg acc cag ttg ttt 499 Leu Lys Lys Lys Ile Leu Val Phe Leu Glu Tyr Leu Thr Gln Leu Phe 120 125 130 gca cat caa act ttg gct gta agt cat tct ctg aag aaa gca att gaa 547 Ala His Gln Thr Leu Ala Val Ser His Ser Leu Lys Lys Ala Ile Glu 135 140 145 gat gcg cac cct cgt ttt aaa gga aga gtg caa gtc tta ggt tat ggc 595 Asp Ala His Pro Arg Phe Lys Gly Arg Val Gln Val Leu Gly Tyr Gly 150 155 160 165 agt atg aat gga gtt gag ctt gat cgc ttt aga gtt cca tcc ctt gaa 643 Ser Met Asn Gly Val Glu Leu Asp Arg Phe Arg Val Pro Ser Leu Glu 170 175 180 gag aaa tta tct gct cgt aat gct tta aac ctg cct agt aaa tct gtc 691 Glu Lys Leu Ser Ala Arg Asn Ala Leu Asn Leu Pro Ser Lys Ser Val 185 190 195 att gtt ggt ttt gtc ggc aga ata aat aaa gat aag gga gga gat ctt 739 Ile Val Gly Phe Val Gly Arg Ile Asn Lys Asp Lys Gly Gly Asp Leu 200 205 210 ctc gct gct ctt aca aaa cat gag gct ttt acc cga ttg cga ctg cat 787 Leu Ala Ala Leu Thr Lys His Glu Ala Phe Thr Arg Leu Arg Leu His 215 220 225 ctc tta att att ggt gaa ttg gaa gac gat gac ttg cga gaa gca ttc 835 Leu Leu Ile Ile Gly Glu Leu Glu Asp Asp Asp Leu Arg Glu Ala Phe 230 235 240 245 att aaa tta gtt aat gaa ggg cag gtt acg att aca gga tgg att gat 883 Ile Lys Leu Val Asn Glu Gly Gln Val Thr Ile Thr Gly Trp Ile Asp 250 255 260 ttc cct gaa gaa cca tta gct gca gtt gat gtt ttg ctt cac cca act 931 Phe Pro Glu Glu Pro Leu Ala Ala Val Asp Val Leu Leu His Pro Thr 265 270 275 cag cga gaa ggt tta ggt atg tct ttg ctg gaa gct cag gct atg gga 979 Gln Arg Glu Gly Leu Gly Met Ser Leu Leu Glu Ala Gln Ala Met Gly 280 285 290 gtg cct gta ttg acg aat gct gtg act gga aca gtt gat gca gta aca 1027 Val Pro Val Leu Thr Asn Ala Val Thr Gly Thr Val Asp Ala Val Thr 295 300 305 agt gga gaa ggt ggc ttt ttt gcc gat gac gat tct gtt gag tcc tgg 1075 Ser Gly Glu Gly Gly Phe Phe Ala Asp Asp Asp Ser Val Glu Ser Trp 310 315 320 325 gtt tct aag att gat tta tta gtt tcc gat cct aag tta aga gac cgg 1123 Val Ser Lys Ile Asp Leu Leu Val Ser Asp Pro Lys Leu Arg Asp Arg 330 335 340 atg gga cgt gct ggt cgc cag ttt gtg tca gct cgt ttc aat cgt gat 1171 Met Gly Arg Ala Gly Arg Gln Phe Val Ser Ala Arg Phe Asn Arg Asp 345 350 355 gat gtc gca gct cgt ttc agt cat ttc gtg gaa caa ttc aaa aaa 1216 Asp Val Ala Ala Arg Phe Ser His Phe Val Glu Gln Phe Lys Lys 360 365 370 tagggctcat tcaatttcaa tattcagata 1246 <210> 130 <211> 372 <212> PRT <213> Corynebacterium glutamicum <400> 130 Val Ile Leu Phe Gly Ala Thr Thr Asp Met Ser Asn Ile Phe Tyr Glu 1 5 10 15 Gly Ile Leu Gln Asn Leu Ile Gln Asp Gly Trp Asp Val His Leu Val 20 25 30 Ser Asn Pro Gly Pro Val Gly Lys Lys Leu Leu Asn Gly Lys Ala His 35 40 45 Thr Ile Glu Met Ser Arg Glu Ile Ser Ile Gly Thr Asp Val Lys Ser 50 55 60 Leu Phe Asn Trp Val Leu Leu Leu Arg Lys Ile Arg Pro Arg Val Leu 65 70 75 80 Ile Val Gly Thr Pro Lys Ala Ser Leu Leu Gly Val Val Ala Ala Arg 85 90 95 Ile Ala Arg Val Pro Arg Ile Val Tyr Val Ala His Gly Leu Arg Ser 100 105 110 Glu Thr Val Leu Gly Leu Lys Lys Lys Ile Leu Val Phe Leu Glu Tyr 115 120 125 Leu Thr Gln Leu Phe Ala His Gln Thr Leu Ala Val Ser His Ser Leu 130 135 140 Lys Lys Ala Ile Glu Asp Ala His Pro Arg Phe Lys Gly Arg Val Gln 145 150 155 160 Val Leu Gly Tyr Gly Ser Met Asn Gly Val Glu Leu Asp Arg Phe Arg 165 170 175 Val Pro Ser Leu Glu Glu Lys Leu Ser Ala Arg Asn Ala Leu Asn Leu 180 185 190 Pro Ser Lys Ser Val Ile Val Gly Phe Val Gly Arg Ile Asn Lys Asp 195 200 205 Lys Gly Gly Asp Leu Leu Ala Ala Leu Thr Lys His Glu Ala Phe Thr 210 215 220 Arg Leu Arg Leu His Leu Leu Ile Ile Gly Glu Leu Glu Asp Asp Asp 225 230 235 240 Leu Arg Glu Ala Phe Ile Lys Leu Val Asn Glu Gly Gln Val Thr Ile 245 250 255 Thr Gly Trp Ile Asp Phe Pro Glu Glu Pro Leu Ala Ala Val Asp Val 260 265 270 Leu Leu His Pro Thr Gln Arg Glu Gly Leu Gly Met Ser Leu Leu Glu 275 280 285 Ala Gln Ala Met Gly Val Pro Val Leu Thr Asn Ala Val Thr Gly Thr 290 295 300 Val Asp Ala Val Thr Ser Gly Glu Gly Gly Phe Phe Ala Asp Asp Asp 305 310 315 320 Ser Val Glu Ser Trp Val Ser Lys Ile Asp Leu Leu Val Ser Asp Pro 325 330 335 Lys Leu Arg Asp Arg Met Gly Arg Ala Gly Arg Gln Phe Val Ser Ala 340 345 350 Arg Phe Asn Arg Asp Asp Val Ala Ala Arg Phe Ser His Phe Val Glu 355 360 365 Gln Phe Lys Lys 370 <210> 131 <211> 1942 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1912) <223> RXA01271 <400> 131 gtgaatccga tgccggacag atcgcagcaa ctcaatttgg agattcagtt ttagcctggg 60 ttggcgaaac ccaatttatt tcaaaagatg gtggacaaac atg gca ata agc att 115 Met Ala Ile Ser Ile 1 5 ggt aaa gca gga cag aac tta aaa ggg tca gtg cct atc gga aaa gtc 163 Gly Lys Ala Gly Gln Asn Leu Lys Gly Ser Val Pro Ile Gly Lys Val 10 15 20 ctt ttt ctc att gat gcc ctt gcc tgg att tct gca cta ttt atc ggt 211 Leu Phe Leu Ile Asp Ala Leu Ala Trp Ile Ser Ala Leu Phe Ile Gly 25 30 35 gtg gtt ttg cgg tat gaa ttc aat ctg agt tct atc aac tgg agt gcg 259 Val Val Leu Arg Tyr Glu Phe Asn Leu Ser Ser Ile Asn Trp Ser Ala 40 45 50 ttt gca tgg ttc ggg ctt gct gca gtt att ttg cag ttt gtt ctc gga 307 Phe Ala Trp Phe Gly Leu Ala Ala Val Ile Leu Gln Phe Val Leu Gly 55 60 65 ctt tct ctc cat ctt tac cgc aag gga tta cgt cac ctt ttc ggt agc 355 Leu Ser Leu His Leu Tyr Arg Lys Gly Leu Arg His Leu Phe Gly Ser 70 75 80 85 ttc gaa gat aca cta aac gtt tct atc tcg gtc att gtt gtc ggt gtt 403 Phe Glu Asp Thr Leu Asn Val Ser Ile Ser Val Ile Val Val Gly Val 90 95 100 gtc ctt tgg atc gcc tca cta ttt gtt ggt cag cgt tgg gaa atc tca 451 Val Leu Trp Ile Ala Ser Leu Phe Val Gly Gln Arg Trp Glu Ile Ser 105 110 115 cgc ggt gtc atg ctg cta gtt atc ccg ctt gct ctc gta ttc gta ttg 499 Arg Gly Val Met Leu Leu Val Ile Pro Leu Ala Leu Val Phe Val Leu 120 125 130 gca gtg cgt tat ctc gcg cgt atg cga gtt gag cgt ctt cgt cgt ccg 547 Ala Val Arg Tyr Leu Ala Arg Met Arg Val Glu Arg Leu Arg Arg Pro 135 140 145 gct gcg gat tcc aca cca gca ttg att ctt ggt ggt gga tac atc ggt 595 Ala Ala Asp Ser Thr Pro Ala Leu Ile Leu Gly Gly Gly Tyr Ile Gly 150 155 160 165 acc aac ctg atc cag tgg atg atg tcc gat cct aag tcg cct ttc cgc 643 Thr Asn Leu Ile Gln Trp Met Met Ser Asp Pro Lys Ser Pro Phe Arg 170 175 180 cca gtc ggc gtt att gat gat aac cct gaa tta gca tgg caa cgc gta 691 Pro Val Gly Val Ile Asp Asp Asn Pro Glu Leu Ala Trp Gln Arg Val 185 190 195 cgt ggt gtg ccg gtt ctt ggc aag ttt gat gat atc gcc caa gtt gca 739 Arg Gly Val Pro Val Leu Gly Lys Phe Asp Asp Ile Ala Gln Val Ala 200 205 210 tca gac act ggc gca gaa ctt ctt atc gtt gct att ggt gat gcc gac 787 Ser Asp Thr Gly Ala Glu Leu Leu Ile Val Ala Ile Gly Asp Ala Asp 215 220 225 tct gca ctt tta agg cgt gtc caa gat acc gct aat aaa aat ggt ctt 835 Ser Ala Leu Leu Arg Arg Val Gln Asp Thr Ala Asn Lys Asn Gly Leu 230 235 240 245 tca gta aag gta atg ccg gct att gac cgc gtc gtt tct aag ggc gtt 883 Ser Val Lys Val Met Pro Ala Ile Asp Arg Val Val Ser Lys Gly Val 250 255 260 cgt gga aac gat ttg cgt gat ctc tct att gaa gat ttg ctt gga cgt 931 Arg Gly Asn Asp Leu Arg Asp Leu Ser Ile Glu Asp Leu Leu Gly Arg 265 270 275 caa cct gtt gaa acc aat gtt tca gaa att act ggc tat cta aca ggt 979 Gln Pro Val Glu Thr Asn Val Ser Glu Ile Thr Gly Tyr Leu Thr Gly 280 285 290 aag cgt gtt ctt gtt acc ggt gca ggt ggg tca att ggt tcc cag cta 1027 Lys Arg Val Leu Val Thr Gly Ala Gly Gly Ser Ile Gly Ser Gln Leu 295 300 305 tgt acg gaa att gcc aaa tac gga cct gct gag ctt atg atg ctt gat 1075 Cys Thr Glu Ile Ala Lys Tyr Gly Pro Ala Glu Leu Met Met Leu Asp 310 315 320 325 cgc gat gag act ggt ttg cag cag gtt ctg att aac gtt gct ggt aac 1123 Arg Asp Glu Thr Gly Leu Gln Gln Val Leu Ile Asn Val Ala Gly Asn 330 335 340 ggt ttg ttg gat acg gat gct gtg gtt ctt gcg gat atc cgc gaa gca 1171 Gly Leu Leu Asp Thr Asp Ala Val Val Leu Ala Asp Ile Arg Glu Ala 345 350 355 gac gcg atg aaa gag att ttt ctc aag cgt aaa cca gaa gtt gtc ttc 1219 Asp Ala Met Lys Glu Ile Phe Leu Lys Arg Lys Pro Glu Val Val Phe 360 365 370 cat gca gca gca tta aag cac ttg cca atg ctg gag cag tat cca gat 1267 His Ala Ala Ala Leu Lys His Leu Pro Met Leu Glu Gln Tyr Pro Asp 375 380 385 gag ggc tgg aaa aca aac gtt cta gga act ctt aac gtt ctt gct gcc 1315 Glu Gly Trp Lys Thr Asn Val Leu Gly Thr Leu Asn Val Leu Ala Ala 390 395 400 405 gca gaa gct gtt ggt gtt gag act ttc gtc aat att tcc acc gat aag 1363 Ala Glu Ala Val Gly Val Glu Thr Phe Val Asn Ile Ser Thr Asp Lys 410 415 420 gca gct aat cca acc agc gtc tta ggg cac tca aag cga gtc gct gaa 1411 Ala Ala Asn Pro Thr Ser Val Leu Gly His Ser Lys Arg Val Ala Glu 425 430 435 aag ctg act gcc tgg tat gga cag aat tcc acc agc aag tac cta tcg 1459 Lys Leu Thr Ala Trp Tyr Gly Gln Asn Ser Thr Ser Lys Tyr Leu Ser 440 445 450 gtt cga ttt gga aac gtc att ggt agc cgt gga tcg atg ctc ccg act 1507 Val Arg Phe Gly Asn Val Ile Gly Ser Arg Gly Ser Met Leu Pro Thr 455 460 465 ttc acc agg cta atc atg gaa gat aaa ccg cta aca gtg acg cac ccg 1555 Phe Thr Arg Leu Ile Met Glu Asp Lys Pro Leu Thr Val Thr His Pro 470 475 480 485 gat gtc act agg ttc ttc atg aca att cct gaa gct tgc caa ttg gtc 1603 Asp Val Thr Arg Phe Phe Met Thr Ile Pro Glu Ala Cys Gln Leu Val 490 495 500 ctg caa gcc ggt ggt att gga cgt tcc ggc gag gtt ctc atc ctt gac 1651 Leu Gln Ala Gly Gly Ile Gly Arg Ser Gly Glu Val Leu Ile Leu Asp 505 510 515 atg ggt gag cct gta agc atc ctt gaa att gca cag cgc atg atc gca 1699 Met Gly Glu Pro Val Ser Ile Leu Glu Ile Ala Gln Arg Met Ile Ala 520 525 530 atg tcc ggt aaa gat att gac atc gtg ttc acc ggc ctt cgc gag ggc 1747 Met Ser Gly Lys Asp Ile Asp Ile Val Phe Thr Gly Leu Arg Glu Gly 535 540 545 gaa aag atg cac gaa gag ctg gtt ggt gat ggt gaa acc gaa gat cgt 1795 Glu Lys Met His Glu Glu Leu Val Gly Asp Gly Glu Thr Glu Asp Arg 550 555 560 565 cca ttc cac tca aag att tcg cat gca cat gca gaa agc ctc gct cct 1843 Pro Phe His Ser Lys Ile Ser His Ala His Ala Glu Ser Leu Ala Pro 570 575 580 aat aat ctc gat aga gat cga ttt atg caa cgt gct gga aaa cta gct 1891 Asn Asn Leu Asp Arg Asp Arg Phe Met Gln Arg Ala Gly Lys Leu Ala 585 590 595 tca aca gat tcg gag atc atc taaatgacta atgaacgaat ttttctatca 1942 Ser Thr Asp Ser Glu Ile Ile 600 <210> 132 <211> 604 <212> PRT <213> Corynebacterium glutamicum <400> 132 Met Ala Ile Ser Ile Gly Lys Ala Gly Gln Asn Leu Lys Gly Ser Val 1 5 10 15 Pro Ile Gly Lys Val Leu Phe Leu Ile Asp Ala Leu Ala Trp Ile Ser 20 25 30 Ala Leu Phe Ile Gly Val Val Leu Arg Tyr Glu Phe Asn Leu Ser Ser 35 40 45 Ile Asn Trp Ser Ala Phe Ala Trp Phe Gly Leu Ala Ala Val Ile Leu 50 55 60 Gln Phe Val Leu Gly Leu Ser Leu His Leu Tyr Arg Lys Gly Leu Arg 65 70 75 80 His Leu Phe Gly Ser Phe Glu Asp Thr Leu Asn Val Ser Ile Ser Val 85 90 95 Ile Val Val Gly Val Val Leu Trp Ile Ala Ser Leu Phe Val Gly Gln 100 105 110 Arg Trp Glu Ile Ser Arg Gly Val Met Leu Leu Val Ile Pro Leu Ala 115 120 125 Leu Val Phe Val Leu Ala Val Arg Tyr Leu Ala Arg Met Arg Val Glu 130 135 140 Arg Leu Arg Arg Pro Ala Ala Asp Ser Thr Pro Ala Leu Ile Leu Gly 145 150 155 160 Gly Gly Tyr Ile Gly Thr Asn Leu Ile Gln Trp Met Met Ser Asp Pro 165 170 175 Lys Ser Pro Phe Arg Pro Val Gly Val Ile Asp Asp Asn Pro Glu Leu 180 185 190 Ala Trp Gln Arg Val Arg Gly Val Pro Val Leu Gly Lys Phe Asp Asp 195 200 205 Ile Ala Gln Val Ala Ser Asp Thr Gly Ala Glu Leu Leu Ile Val Ala 210 215 220 Ile Gly Asp Ala Asp Ser Ala Leu Leu Arg Arg Val Gln Asp Thr Ala 225 230 235 240 Asn Lys Asn Gly Leu Ser Val Lys Val Met Pro Ala Ile Asp Arg Val 245 250 255 Val Ser Lys Gly Val Arg Gly Asn Asp Leu Arg Asp Leu Ser Ile Glu 260 265 270 Asp Leu Leu Gly Arg Gln Pro Val Glu Thr Asn Val Ser Glu Ile Thr 275 280 285 Gly Tyr Leu Thr Gly Lys Arg Val Leu Val Thr Gly Ala Gly Gly Ser 290 295 300 Ile Gly Ser Gln Leu Cys Thr Glu Ile Ala Lys Tyr Gly Pro Ala Glu 305 310 315 320 Leu Met Met Leu Asp Arg Asp Glu Thr Gly Leu Gln Gln Val Leu Ile 325 330 335 Asn Val Ala Gly Asn Gly Leu Leu Asp Thr Asp Ala Val Val Leu Ala 340 345 350 Asp Ile Arg Glu Ala Asp Ala Met Lys Glu Ile Phe Leu Lys Arg Lys 355 360 365 Pro Glu Val Val Phe His Ala Ala Ala Leu Lys His Leu Pro Met Leu 370 375 380 Glu Gln Tyr Pro Asp Glu Gly Trp Lys Thr Asn Val Leu Gly Thr Leu 385 390 395 400 Asn Val Leu Ala Ala Ala Glu Ala Val Gly Val Glu Thr Phe Val Asn 405 410 415 Ile Ser Thr Asp Lys Ala Ala Asn Pro Thr Ser Val Leu Gly His Ser 420 425 430 Lys Arg Val Ala Glu Lys Leu Thr Ala Trp Tyr Gly Gln Asn Ser Thr 435 440 445 Ser Lys Tyr Leu Ser Val Arg Phe Gly Asn Val Ile Gly Ser Arg Gly 450 455 460 Ser Met Leu Pro Thr Phe Thr Arg Leu Ile Met Glu Asp Lys Pro Leu 465 470 475 480 Thr Val Thr His Pro Asp Val Thr Arg Phe Phe Met Thr Ile Pro Glu 485 490 495 Ala Cys Gln Leu Val Leu Gln Ala Gly Gly Ile Gly Arg Ser Gly Glu 500 505 510 Val Leu Ile Leu Asp Met Gly Glu Pro Val Ser Ile Leu Glu Ile Ala 515 520 525 Gln Arg Met Ile Ala Met Ser Gly Lys Asp Ile Asp Ile Val Phe Thr 530 535 540 Gly Leu Arg Glu Gly Glu Lys Met His Glu Glu Leu Val Gly Asp Gly 545 550 555 560 Glu Thr Glu Asp Arg Pro Phe His Ser Lys Ile Ser His Ala His Ala 565 570 575 Glu Ser Leu Ala Pro Asn Asn Leu Asp Arg Asp Arg Phe Met Gln Arg 580 585 590 Ala Gly Lys Leu Ala Ser Thr Asp Ser Glu Ile Ile 595 600 <210> 133 <211> 1564 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1534) <223> RXA01273 <400> 133 gacctattca gcgctggatt ttttctggca ttttcttggc agtcagtgag ttgctaacgt 60 tctattggtt aaaaattgat ctgcaagagg actgcaaaat atg gaa tta agg gaa 115 Met Glu Leu Arg Glu 1 5 tac gcg aca atc ctg atg aag aat tgg gtg ttg atc gtt atc gca tcc 163 Tyr Ala Thr Ile Leu Met Lys Asn Trp Val Leu Ile Val Ile Ala Ser 10 15 20 att ctt gga att gca gcg ggc gct ggt ttt tcc ctt cta gct aca ccg 211 Ile Leu Gly Ile Ala Ala Gly Ala Gly Phe Ser Leu Leu Ala Thr Pro 25 30 35 gag tat cag tca cgt act cag ttg tat gta tcg gtg cgg tcg ggg gct 259 Glu Tyr Gln Ser Arg Thr Gln Leu Tyr Val Ser Val Arg Ser Gly Ala 40 45 50 ggg aca acc tct gac atg gtt cag ggt gct aac ttt tcg cgt cag att 307 Gly Thr Thr Ser Asp Met Val Gln Gly Ala Asn Phe Ser Arg Gln Ile 55 60 65 gtg aat agt tat gtt gat gtc att aag acg ggt gtt gtt cta gag ccg 355 Val Asn Ser Tyr Val Asp Val Ile Lys Thr Gly Val Val Leu Glu Pro 70 75 80 85 gtt gtt gat gag ctt ggt ctg gag ttg acg gct aac cag ttg agt tct 403 Val Val Asp Glu Leu Gly Leu Glu Leu Thr Ala Asn Gln Leu Ser Ser 90 95 100 cat atc agt gcg gct tct cct gct gat act gcg ttg atc aac atc act 451 His Ile Ser Ala Ala Ser Pro Ala Asp Thr Ala Leu Ile Asn Ile Thr 105 110 115 gct tct agt cct tct cct cag cag gcg gct gag atc gcc aat gca gtg 499 Ala Ser Ser Pro Ser Pro Gln Gln Ala Ala Glu Ile Ala Asn Ala Val 120 125 130 ggg gag agt ttc aag aat gtg att cag act gaa ttg gaa cca gac tcc 547 Gly Glu Ser Phe Lys Asn Val Ile Gln Thr Glu Leu Glu Pro Asp Ser 135 140 145 ggc gat ggc atg agc ccg att aac ctg act act act cag gtg gct ctg 595 Gly Asp Gly Met Ser Pro Ile Asn Leu Thr Thr Thr Gln Val Ala Leu 150 155 160 165 gaa cca tct tct ccg gtc agt cct aat gtg atg atg aat atc ctc ctc 643 Glu Pro Ser Ser Pro Val Ser Pro Asn Val Met Met Asn Ile Leu Leu 170 175 180 ggc cta ctt gta ggt ctt gca ata ggt gtt ggt att gca gtg ctt cgc 691 Gly Leu Leu Val Gly Leu Ala Ile Gly Val Gly Ile Ala Val Leu Arg 185 190 195 gcg gct ttg gat act cgt att cat tcc ttg cgc gat att gaa gag gtt 739 Ala Ala Leu Asp Thr Arg Ile His Ser Leu Arg Asp Ile Glu Glu Val 200 205 210 act gat aag cca ctt ttg ggc gga atc att gcg gat tct gaa gtt gag 787 Thr Asp Lys Pro Leu Leu Gly Gly Ile Ile Ala Asp Ser Glu Val Glu 215 220 225 aag cac ccg ttg atc att aag cac aag ccg cat agt cct att gcg gag 835 Lys His Pro Leu Ile Ile Lys His Lys Pro His Ser Pro Ile Ala Glu 230 235 240 245 tcc ttt cgt gcg tta cgt act aac ctg cag ttc ctt aac gtc ggc ggc 883 Ser Phe Arg Ala Leu Arg Thr Asn Leu Gln Phe Leu Asn Val Gly Gly 250 255 260 tca tct tca gta ttt gtt atc tcc tct gct aat cct ggt gag ggt aag 931 Ser Ser Ser Val Phe Val Ile Ser Ser Ala Asn Pro Gly Glu Gly Lys 265 270 275 tca acc act tct gta aac cta gct ttg gcg ctt gca gag gcc ggc tcc 979 Ser Thr Thr Ser Val Asn Leu Ala Leu Ala Leu Ala Glu Ala Gly Ser 280 285 290 cgt gta gcg ctg atc gaa gct gat ctt cgc ttg cca cga gtg agc aag 1027 Arg Val Ala Leu Ile Glu Ala Asp Leu Arg Leu Pro Arg Val Ser Lys 295 300 305 tac ctc gga gtt gag ggc aac gca ggt ctg act gac att ctc att ggc 1075 Tyr Leu Gly Val Glu Gly Asn Ala Gly Leu Thr Asp Ile Leu Ile Gly 310 315 320 325 aag gcc gag gtt aat gat gtg ttg cag cgt tgg ggt agg act cag ttg 1123 Lys Ala Glu Val Asn Asp Val Leu Gln Arg Trp Gly Arg Thr Gln Leu 330 335 340 tac tat ctc ccg gca ggg cgc att ccg ccg aac ccg agt gag ttg ctt 1171 Tyr Tyr Leu Pro Ala Gly Arg Ile Pro Pro Asn Pro Ser Glu Leu Leu 345 350 355 ggt tca gct gag atg gac aag gtc att gcg gag ctt gag gaa agc ttt 1219 Gly Ser Ala Glu Met Asp Lys Val Ile Ala Glu Leu Glu Glu Ser Phe 360 365 370 gat tat gtg atc atc gat gcc cct ccg gcg ttg gcg gtt acc gat gct 1267 Asp Tyr Val Ile Ile Asp Ala Pro Pro Ala Leu Ala Val Thr Asp Ala 375 380 385 gca gtt att ggt cat ggc aag gct ggc atc ctg att gcg gtc tcc gca 1315 Ala Val Ile Gly His Gly Lys Ala Gly Ile Leu Ile Ala Val Ser Ala 390 395 400 405 ggt tct aca aag aag cct gag ttg gaa gct acg ctg tcc acg ctt gag 1363 Gly Ser Thr Lys Lys Pro Glu Leu Glu Ala Thr Leu Ser Thr Leu Glu 410 415 420 aat gcg gat gcc aat gtt gtt ggc gtt gtc gct acg atg ctc ccg cct 1411 Asn Ala Asp Ala Asn Val Val Gly Val Val Ala Thr Met Leu Pro Pro 425 430 435 aag tct gtg gct ggt tat ggc tac gga aat tac ggc tac ggc gac acc 1459 Lys Ser Val Ala Gly Tyr Gly Tyr Gly Asn Tyr Gly Tyr Gly Asp Thr 440 445 450 tcc aaa atc aat gcc cct aag ccc gac aac acc gaa cta acc acc acc 1507 Ser Lys Ile Asn Ala Pro Lys Pro Asp Asn Thr Glu Leu Thr Thr Thr 455 460 465 gat gct tcc aag gcc aac aat gag caa tagcttcact attctcactg 1554 Asp Ala Ser Lys Ala Asn Asn Glu Gln 470 475 tctgtactgg 1564 <210> 134 <211> 478 <212> PRT <213> Corynebacterium glutamicum <400> 134 Met Glu Leu Arg Glu Tyr Ala Thr Ile Leu Met Lys Asn Trp Val Leu 1 5 10 15 Ile Val Ile Ala Ser Ile Leu Gly Ile Ala Ala Gly Ala Gly Phe Ser 20 25 30 Leu Leu Ala Thr Pro Glu Tyr Gln Ser Arg Thr Gln Leu Tyr Val Ser 35 40 45 Val Arg Ser Gly Ala Gly Thr Thr Ser Asp Met Val Gln Gly Ala Asn 50 55 60 Phe Ser Arg Gln Ile Val Asn Ser Tyr Val Asp Val Ile Lys Thr Gly 65 70 75 80 Val Val Leu Glu Pro Val Val Asp Glu Leu Gly Leu Glu Leu Thr Ala 85 90 95 Asn Gln Leu Ser Ser His Ile Ser Ala Ala Ser Pro Ala Asp Thr Ala 100 105 110 Leu Ile Asn Ile Thr Ala Ser Ser Pro Ser Pro Gln Gln Ala Ala Glu 115 120 125 Ile Ala Asn Ala Val Gly Glu Ser Phe Lys Asn Val Ile Gln Thr Glu 130 135 140 Leu Glu Pro Asp Ser Gly Asp Gly Met Ser Pro Ile Asn Leu Thr Thr 145 150 155 160 Thr Gln Val Ala Leu Glu Pro Ser Ser Pro Val Ser Pro Asn Val Met 165 170 175 Met Asn Ile Leu Leu Gly Leu Leu Val Gly Leu Ala Ile Gly Val Gly 180 185 190 Ile Ala Val Leu Arg Ala Ala Leu Asp Thr Arg Ile His Ser Leu Arg 195 200 205 Asp Ile Glu Glu Val Thr Asp Lys Pro Leu Leu Gly Gly Ile Ile Ala 210 215 220 Asp Ser Glu Val Glu Lys His Pro Leu Ile Ile Lys His Lys Pro His 225 230 235 240 Ser Pro Ile Ala Glu Ser Phe Arg Ala Leu Arg Thr Asn Leu Gln Phe 245 250 255 Leu Asn Val Gly Gly Ser Ser Ser Val Phe Val Ile Ser Ser Ala Asn 260 265 270 Pro Gly Glu Gly Lys Ser Thr Thr Ser Val Asn Leu Ala Leu Ala Leu 275 280 285 Ala Glu Ala Gly Ser Arg Val Ala Leu Ile Glu Ala Asp Leu Arg Leu 290 295 300 Pro Arg Val Ser Lys Tyr Leu Gly Val Glu Gly Asn Ala Gly Leu Thr 305 310 315 320 Asp Ile Leu Ile Gly Lys Ala Glu Val Asn Asp Val Leu Gln Arg Trp 325 330 335 Gly Arg Thr Gln Leu Tyr Tyr Leu Pro Ala Gly Arg Ile Pro Pro Asn 340 345 350 Pro Ser Glu Leu Leu Gly Ser Ala Glu Met Asp Lys Val Ile Ala Glu 355 360 365 Leu Glu Glu Ser Phe Asp Tyr Val Ile Ile Asp Ala Pro Pro Ala Leu 370 375 380 Ala Val Thr Asp Ala Ala Val Ile Gly His Gly Lys Ala Gly Ile Leu 385 390 395 400 Ile Ala Val Ser Ala Gly Ser Thr Lys Lys Pro Glu Leu Glu Ala Thr 405 410 415 Leu Ser Thr Leu Glu Asn Ala Asp Ala Asn Val Val Gly Val Val Ala 420 425 430 Thr Met Leu Pro Pro Lys Ser Val Ala Gly Tyr Gly Tyr Gly Asn Tyr 435 440 445 Gly Tyr Gly Asp Thr Ser Lys Ile Asn Ala Pro Lys Pro Asp Asn Thr 450 455 460 Glu Leu Thr Thr Thr Asp Ala Ser Lys Ala Asn Asn Glu Gln 465 470 475 <210> 135 <211> 781 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(751) <223> RXA01315 <400> 135 catgtgcggt tgtgtcctaa gtcattgatg tcacctaacg cccctaagtt cactcggtgc 60 aatattgcac tgagtgcaag tttacactag gtttacttca gtg gat att gaa gag 115 Val Asp Ile Glu Glu 1 5 cag ccc tcg tta aga gaa atc aag cgc caa atg acc ctg gaa gcg ata 163 Gln Pro Ser Leu Arg Glu Ile Lys Arg Gln Met Thr Leu Glu Ala Ile 10 15 20 gaa gat aac gca acc agg ctc att ctg gag cgt ggc ttc gac aat gtc 211 Glu Asp Asn Ala Thr Arg Leu Ile Leu Glu Arg Gly Phe Asp Asn Val 25 30 35 aca atc gaa gac atc tgc gca gag gca ggg ata tcc aag cgc aca ttc 259 Thr Ile Glu Asp Ile Cys Ala Glu Ala Gly Ile Ser Lys Arg Thr Phe 40 45 50 ttt aac tac gtg gag tcc aaa gag tct gtg gcc atc ggg cac aca gcc 307 Phe Asn Tyr Val Glu Ser Lys Glu Ser Val Ala Ile Gly His Thr Ala 55 60 65 aag ctc cca acg gat gaa gaa cgt gaa gca ttc ctg gct acg cgt cat 355 Lys Leu Pro Thr Asp Glu Glu Arg Glu Ala Phe Leu Ala Thr Arg His 70 75 80 85 gaa aat att atc gat act gta ttt gac ctg gta atc aac ctc ttt ggc 403 Glu Asn Ile Ile Asp Thr Val Phe Asp Leu Val Ile Asn Leu Phe Gly 90 95 100 aac cac gac aac tcc aag tct gga gtt gca ggc gac att atg cgt cga 451 Asn His Asp Asn Ser Lys Ser Gly Val Ala Gly Asp Ile Met Arg Arg 105 110 115 cgc aaa gag atc cgg gtg aag cat cca gaa ctg gca gtg caa cat ttc 499 Arg Lys Glu Ile Arg Val Lys His Pro Glu Leu Ala Val Gln His Phe 120 125 130 gcc agg ttc cac caa gca cgc gaa ggg cta gaa cac cta att gtt gag 547 Ala Arg Phe His Gln Ala Arg Glu Gly Leu Glu His Leu Ile Val Glu 135 140 145 tac ttc gaa aaa tgg cca ggc tcc caa cat cta gat gag cct gca gat 595 Tyr Phe Glu Lys Trp Pro Gly Ser Gln His Leu Asp Glu Pro Ala Asp 150 155 160 165 cga gaa gca atc gcc ata gtt ggc ctg ctg atc tcg gtc atg ctt caa 643 Arg Glu Ala Ile Ala Ile Val Gly Leu Leu Ile Ser Val Met Leu Gln 170 175 180 ggt tct cgt gaa tgg cac gac atg cca caa ggc acg caa gct gat ttc 691 Gly Ser Arg Glu Trp His Asp Met Pro Gln Gly Thr Gln Ala Asp Phe 185 190 195 caa gcc tgc tgt cgc aaa gca att aaa aat act ttt ctt ctt aga ggt 739 Gln Ala Cys Cys Arg Lys Ala Ile Lys Asn Thr Phe Leu Leu Arg Gly 200 205 210 gga ttt tca gaa tgacatcaca ggtcaagccg gacgacgaac 781 Gly Phe Ser Glu 215 <210> 136 <211> 217 <212> PRT <213> Corynebacterium glutamicum <400> 136 Val Asp Ile Glu Glu Gln Pro Ser Leu Arg Glu Ile Lys Arg Gln Met 1 5 10 15 Thr Leu Glu Ala Ile Glu Asp Asn Ala Thr Arg Leu Ile Leu Glu Arg 20 25 30 Gly Phe Asp Asn Val Thr Ile Glu Asp Ile Cys Ala Glu Ala Gly Ile 35 40 45 Ser Lys Arg Thr Phe Phe Asn Tyr Val Glu Ser Lys Glu Ser Val Ala 50 55 60 Ile Gly His Thr Ala Lys Leu Pro Thr Asp Glu Glu Arg Glu Ala Phe 65 70 75 80 Leu Ala Thr Arg His Glu Asn Ile Ile Asp Thr Val Phe Asp Leu Val 85 90 95 Ile Asn Leu Phe Gly Asn His Asp Asn Ser Lys Ser Gly Val Ala Gly 100 105 110 Asp Ile Met Arg Arg Arg Lys Glu Ile Arg Val Lys His Pro Glu Leu 115 120 125 Ala Val Gln His Phe Ala Arg Phe His Gln Ala Arg Glu Gly Leu Glu 130 135 140 His Leu Ile Val Glu Tyr Phe Glu Lys Trp Pro Gly Ser Gln His Leu 145 150 155 160 Asp Glu Pro Ala Asp Arg Glu Ala Ile Ala Ile Val Gly Leu Leu Ile 165 170 175 Ser Val Met Leu Gln Gly Ser Arg Glu Trp His Asp Met Pro Gln Gly 180 185 190 Thr Gln Ala Asp Phe Gln Ala Cys Cys Arg Lys Ala Ile Lys Asn Thr 195 200 205 Phe Leu Leu Arg Gly Gly Phe Ser Glu 210 215 <210> 137 <211> 1432 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1402) <223> RXA01318 <400> 137 cggacgcgtt ccagagaaag tgcaggcata acccctaaaa taccctgatc ttcccccgtg 60 tcctgccccc gtgtccaccc ctgcgtacat aataggacgc atg gga aaa cat gag 115 Met Gly Lys His Glu 1 5 gtt gct cag cag acg gtt ccg ggt cct tcg ccg gaa atg gaa gcg cag 163 Val Ala Gln Gln Thr Val Pro Gly Pro Ser Pro Glu Met Glu Ala Gln 10 15 20 cgg cgt aaa gag ttg cgc aag cac aag gcc att gcc act ggc ctg ttg 211 Arg Arg Lys Glu Leu Arg Lys His Lys Ala Ile Ala Thr Gly Leu Leu 25 30 35 att ttt gct gcc gct gta tat ttt ctt tgc cgt ttc gtg gag acc cgt 259 Ile Phe Ala Ala Ala Val Tyr Phe Leu Cys Arg Phe Val Glu Thr Arg 40 45 50 ccg ggt gaa act gca gcg tgg gta ggt ttt gtg cgc gct gcg gca gag 307 Pro Gly Glu Thr Ala Ala Trp Val Gly Phe Val Arg Ala Ala Ala Glu 55 60 65 gcc gga atg att ggc ggg ttg gcc gac tgg ttc gcg gtc acc gcg ctg 355 Ala Gly Met Ile Gly Gly Leu Ala Asp Trp Phe Ala Val Thr Ala Leu 70 75 80 85 ttc cgt cat cca ttg tgg ctg cct att ccg cac act gcg att atc ccg 403 Phe Arg His Pro Leu Trp Leu Pro Ile Pro His Thr Ala Ile Ile Pro 90 95 100 cgc aag aaa gac cag tta ggt gag gcc tta agc ggg ttt gtg ggg gat 451 Arg Lys Lys Asp Gln Leu Gly Glu Ala Leu Ser Gly Phe Val Gly Asp 105 110 115 aac ttc cta aat gcc cag ctc att acg gaa aaa gtc tct cag gcg cgg 499 Asn Phe Leu Asn Ala Gln Leu Ile Thr Glu Lys Val Ser Gln Ala Arg 120 125 130 atc cca gag cgc gcc ggg gag tgg ctc gcc cag ccg gaa aac ggg gag 547 Ile Pro Glu Arg Ala Gly Glu Trp Leu Ala Gln Pro Glu Asn Gly Glu 135 140 145 aaa gtt tcg cgc gaa gtc ggc aaa ttg acc gct aat att gtg cgc gca 595 Lys Val Ser Arg Glu Val Gly Lys Leu Thr Ala Asn Ile Val Arg Ala 150 155 160 165 atc gat ccg tca gat gct gaa gcg gtg att aaa tct gcg gtg atc gac 643 Ile Asp Pro Ser Asp Ala Glu Ala Val Ile Lys Ser Ala Val Ile Asp 170 175 180 aag ctt gcg gaa ccc acc tgg ggc cca cca gct ggg cgg ttg ctg gaa 691 Lys Leu Ala Glu Pro Thr Trp Gly Pro Pro Ala Gly Arg Leu Leu Glu 185 190 195 caa ctc ctc gcc gaa ggc aaa gcc gaa cca gtt gtc cag gaa ctc gcg 739 Gln Leu Leu Ala Glu Gly Lys Ala Glu Pro Val Val Gln Glu Leu Ala 200 205 210 cag tgg ctg cac aaa aag gcg ttg ggc tcc gag ccg ctg att gat cgc 787 Gln Trp Leu His Lys Lys Ala Leu Gly Ser Glu Pro Leu Ile Asp Arg 215 220 225 ctg ctc aac gag cgc cgc ccg att tgg gcg ccg aaa ttc act gcg cag 835 Leu Leu Asn Glu Arg Arg Pro Ile Trp Ala Pro Lys Phe Thr Ala Gln 230 235 240 245 ctg gtc agc ggc aaa gtc tat gac gag gtc ata aaa ttc act gaa gcc 883 Leu Val Ser Gly Lys Val Tyr Asp Glu Val Ile Lys Phe Thr Glu Ala 250 255 260 gtc gct gcc gat cct aac cac gag gcc cgc aaa tcg ctg cgc cga ttc 931 Val Ala Ala Asp Pro Asn His Glu Ala Arg Lys Ser Leu Arg Arg Phe 265 270 275 ctt aat aaa ttg gcg caa gac ctg cag cat gac cca ggc atg att att 979 Leu Asn Lys Leu Ala Gln Asp Leu Gln His Asp Pro Gly Met Ile Ile 280 285 290 aaa gtt gaa gaa atc aaa cgc gac atc atg ggc tcc ggc gcc atc gcg 1027 Lys Val Glu Glu Ile Lys Arg Asp Ile Met Gly Ser Gly Ala Ile Ala 295 300 305 caa gcc gcg cca acc atc tgg gcg tca gcc tcc gag tcg ctc att gaa 1075 Gln Ala Ala Pro Thr Ile Trp Ala Ser Ala Ser Glu Ser Leu Ile Glu 310 315 320 325 tcc gca gaa gat gag tca tca att ctg cgt cgc aaa att gcc gaa gca 1123 Ser Ala Glu Asp Glu Ser Ser Ile Leu Arg Arg Lys Ile Ala Glu Ala 330 335 340 gct acc agc tgg ggt caa aga ttg ctt gtc gac gac tcc ctc cgg cat 1171 Ala Thr Ser Trp Gly Gln Arg Leu Leu Val Asp Asp Ser Leu Arg His 345 350 355 tca ctc gac acc cgg att acc ggc gcc gct gct ttc ctc gcc gac aat 1219 Ser Leu Asp Thr Arg Ile Thr Gly Ala Ala Ala Phe Leu Ala Asp Asn 360 365 370 tac gcc ccc gaa gtc acc ggc att atc tcc gaa acc att gaa cga tgg 1267 Tyr Ala Pro Glu Val Thr Gly Ile Ile Ser Glu Thr Ile Glu Arg Trp 375 380 385 gac gct gaa gaa gct tca gag aaa atc gaa ctc atg gtg ggc aaa gac 1315 Asp Ala Glu Glu Ala Ser Glu Lys Ile Glu Leu Met Val Gly Lys Asp 390 395 400 405 ctc caa tac atc cgc ctt aat ggc aca att gta ggt gca tta gca gga 1363 Leu Gln Tyr Ile Arg Leu Asn Gly Thr Ile Val Gly Ala Leu Ala Gly 410 415 420 ctg gcc att tac gct att tcc cat atc ctc ttc gga gct taactaggag 1412 Leu Ala Ile Tyr Ala Ile Ser His Ile Leu Phe Gly Ala 425 430 taaccatcat gtccgatgca 1432 <210> 138 <211> 434 <212> PRT <213> Corynebacterium glutamicum <400> 138 Met Gly Lys His Glu Val Ala Gln Gln Thr Val Pro Gly Pro Ser Pro 1 5 10 15 Glu Met Glu Ala Gln Arg Arg Lys Glu Leu Arg Lys His Lys Ala Ile 20 25 30 Ala Thr Gly Leu Leu Ile Phe Ala Ala Ala Val Tyr Phe Leu Cys Arg 35 40 45 Phe Val Glu Thr Arg Pro Gly Glu Thr Ala Ala Trp Val Gly Phe Val 50 55 60 Arg Ala Ala Ala Glu Ala Gly Met Ile Gly Gly Leu Ala Asp Trp Phe 65 70 75 80 Ala Val Thr Ala Leu Phe Arg His Pro Leu Trp Leu Pro Ile Pro His 85 90 95 Thr Ala Ile Ile Pro Arg Lys Lys Asp Gln Leu Gly Glu Ala Leu Ser 100 105 110 Gly Phe Val Gly Asp Asn Phe Leu Asn Ala Gln Leu Ile Thr Glu Lys 115 120 125 Val Ser Gln Ala Arg Ile Pro Glu Arg Ala Gly Glu Trp Leu Ala Gln 130 135 140 Pro Glu Asn Gly Glu Lys Val Ser Arg Glu Val Gly Lys Leu Thr Ala 145 150 155 160 Asn Ile Val Arg Ala Ile Asp Pro Ser Asp Ala Glu Ala Val Ile Lys 165 170 175 Ser Ala Val Ile Asp Lys Leu Ala Glu Pro Thr Trp Gly Pro Pro Ala 180 185 190 Gly Arg Leu Leu Glu Gln Leu Leu Ala Glu Gly Lys Ala Glu Pro Val 195 200 205 Val Gln Glu Leu Ala Gln Trp Leu His Lys Lys Ala Leu Gly Ser Glu 210 215 220 Pro Leu Ile Asp Arg Leu Leu Asn Glu Arg Arg Pro Ile Trp Ala Pro 225 230 235 240 Lys Phe Thr Ala Gln Leu Val Ser Gly Lys Val Tyr Asp Glu Val Ile 245 250 255 Lys Phe Thr Glu Ala Val Ala Ala Asp Pro Asn His Glu Ala Arg Lys 260 265 270 Ser Leu Arg Arg Phe Leu Asn Lys Leu Ala Gln Asp Leu Gln His Asp 275 280 285 Pro Gly Met Ile Ile Lys Val Glu Glu Ile Lys Arg Asp Ile Met Gly 290 295 300 Ser Gly Ala Ile Ala Gln Ala Ala Pro Thr Ile Trp Ala Ser Ala Ser 305 310 315 320 Glu Ser Leu Ile Glu Ser Ala Glu Asp Glu Ser Ser Ile Leu Arg Arg 325 330 335 Lys Ile Ala Glu Ala Ala Thr Ser Trp Gly Gln Arg Leu Leu Val Asp 340 345 350 Asp Ser Leu Arg His Ser Leu Asp Thr Arg Ile Thr Gly Ala Ala Ala 355 360 365 Phe Leu Ala Asp Asn Tyr Ala Pro Glu Val Thr Gly Ile Ile Ser Glu 370 375 380 Thr Ile Glu Arg Trp Asp Ala Glu Glu Ala Ser Glu Lys Ile Glu Leu 385 390 395 400 Met Val Gly Lys Asp Leu Gln Tyr Ile Arg Leu Asn Gly Thr Ile Val 405 410 415 Gly Ala Leu Ala Gly Leu Ala Ile Tyr Ala Ile Ser His Ile Leu Phe 420 425 430 Gly Ala <210> 139 <211> 496 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(466) <223> RXA01326 <400> 139 gtccttgagg ctgcttacac tctacttatt gtagaaatgg gagggtcgtg gcgtcgaaaa 60 gcaaacatct tttaacgctt ttggcccgta ttatggtggc atg gct ttc ccc gtg 115 Met Ala Phe Pro Val 1 5 aca gaa gac aaa atc ctg gca gct gag gaa acc ctt ggc agg cgc ctc 163 Thr Glu Asp Lys Ile Leu Ala Ala Glu Glu Thr Leu Gly Arg Arg Leu 10 15 20 ccc gaa act ttg cgc gaa cga cta ctt caa aac aat ggt ggc gaa gtc 211 Pro Glu Thr Leu Arg Glu Arg Leu Leu Gln Asn Asn Gly Gly Glu Val 25 30 35 atc gac aat gaa aac aac gac tgg att ctc cat cca gtt cgt gat gac 259 Ile Asp Asn Glu Asn Asn Asp Trp Ile Leu His Pro Val Arg Asp Asp 40 45 50 agc gac cga aaa agg ctt gtc cga act gcc aac gac atc atc cgc gag 307 Ser Asp Arg Lys Arg Leu Val Arg Thr Ala Asn Asp Ile Ile Arg Glu 55 60 65 acc gaa tct gca cgt gaa tgg gac aat ttc ccc gaa aat gcg atc gca 355 Thr Glu Ser Ala Arg Glu Trp Asp Asn Phe Pro Glu Asn Ala Ile Ala 70 75 80 85 att gca aat gac gga acg ggc gac tta ata att ctg ctt ccc gac gat 403 Ile Ala Asn Asp Gly Thr Gly Asp Leu Ile Ile Leu Leu Pro Asp Asp 90 95 100 gat gct ttc tac atc tgg tcg cac gaa gat gaa ccc ctg atc gaa act 451 Asp Ala Phe Tyr Ile Trp Ser His Glu Asp Glu Pro Leu Ile Glu Thr 105 110 115 gaa ctt gag gat gcc taaaacagct ggacagaatt cgacttggaa 496 Glu Leu Glu Asp Ala 120 <210> 140 <211> 122 <212> PRT <213> Corynebacterium glutamicum <400> 140 Met Ala Phe Pro Val Thr Glu Asp Lys Ile Leu Ala Ala Glu Glu Thr 1 5 10 15 Leu Gly Arg Arg Leu Pro Glu Thr Leu Arg Glu Arg Leu Leu Gln Asn 20 25 30 Asn Gly Gly Glu Val Ile Asp Asn Glu Asn Asn Asp Trp Ile Leu His 35 40 45 Pro Val Arg Asp Asp Ser Asp Arg Lys Arg Leu Val Arg Thr Ala Asn 50 55 60 Asp Ile Ile Arg Glu Thr Glu Ser Ala Arg Glu Trp Asp Asn Phe Pro 65 70 75 80 Glu Asn Ala Ile Ala Ile Ala Asn Asp Gly Thr Gly Asp Leu Ile Ile 85 90 95 Leu Leu Pro Asp Asp Asp Ala Phe Tyr Ile Trp Ser His Glu Asp Glu 100 105 110 Pro Leu Ile Glu Thr Glu Leu Glu Asp Ala 115 120 <210> 141 <211> 2527 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2497) <223> RXA01331 <400> 141 ctaaactcgt ctctcgtatc tttcagtcat ttatgtctga taagcaggcg cgtgcgccac 60 acaattggca caatcacaag aaagtgaagt gggaacctag atg ctg acg aca cta 115 Met Leu Thr Thr Leu 1 5 tgg att gcg gtg ttg gta ttt acc gtt cca gga ttg gtc gtc tcg tgg 163 Trp Ile Ala Val Leu Val Phe Thr Val Pro Gly Leu Val Val Ser Trp 10 15 20 gtt tct ggc ctt aaa gtg ccc tgg gct atc gca gcc tcc atc cca gcc 211 Val Ser Gly Leu Lys Val Pro Trp Ala Ile Ala Ala Ser Ile Pro Ala 25 30 35 acc ttc ggt att tac ggc ctg tcc gcc tgg ttg ctg ggc ttg tgg gag 259 Thr Phe Gly Ile Tyr Gly Leu Ser Ala Trp Leu Leu Gly Leu Trp Glu 40 45 50 atg cgt ttt gat ctc cat tct gta gtt att tcc aca ttg gtt ttc gct 307 Met Arg Phe Asp Leu His Ser Val Val Ile Ser Thr Leu Val Phe Ala 55 60 65 gcg gtt gct ttg gta tgg cgc ttg ttt ttt gtc ggt ggt tgg ctt gta 355 Ala Val Ala Leu Val Trp Arg Leu Phe Phe Val Gly Gly Trp Leu Val 70 75 80 85 cgt cgg cgt aaa gca cgt atc cgc agg cag acg ctc gcg gat gaa gag 403 Arg Arg Arg Lys Ala Arg Ile Arg Arg Gln Thr Leu Ala Asp Glu Glu 90 95 100 cgg gca gaa aat gct gag gta tct gca ggg gag cct gcc gaa tcg agc 451 Arg Ala Glu Asn Ala Glu Val Ser Ala Gly Glu Pro Ala Glu Ser Ser 105 110 115 aca aac gaa gca gcc gaa tct gaa tct gaa acc tcg gag cgt cgc gga 499 Thr Asn Glu Ala Ala Glu Ser Glu Ser Glu Thr Ser Glu Arg Arg Gly 120 125 130 atc tgg cgc gtg atc ttt gat tac atg cgc gac ggt ggc atc ttg gat 547 Ile Trp Arg Val Ile Phe Asp Tyr Met Arg Asp Gly Gly Ile Leu Asp 135 140 145 cac cgt tgg ctg ctg cct gcc gca ggt gct atc act ggt gcg tgg ctg 595 His Arg Trp Leu Leu Pro Ala Ala Gly Ala Ile Thr Gly Ala Trp Leu 150 155 160 165 atc att gat cgt gcc gtt gat ctg ctc ttg agc acc gag cat ggt ttg 643 Ile Ile Asp Arg Ala Val Asp Leu Leu Leu Ser Thr Glu His Gly Leu 170 175 180 ggc gat atc gtc caa ggc tgg gat gtc cat tgg cat gct tcg act gtc 691 Gly Asp Ile Val Gln Gly Trp Asp Val His Trp His Ala Ser Thr Val 185 190 195 cgt ttt ata gat gag acc ggc att gcg tca tcc acg atg atg ggg cag 739 Arg Phe Ile Asp Glu Thr Gly Ile Ala Ser Ser Thr Met Met Gly Gln 200 205 210 ctg cgc aat att gaa acg cag caa gat ctg ttc tac cca agc gca tgg 787 Leu Arg Asn Ile Glu Thr Gln Gln Asp Leu Phe Tyr Pro Ser Ala Trp 215 220 225 cat gct ggt gca tgg gtg ctg tcg gat gtc gga aat ctg acg att gtt 835 His Ala Gly Ala Trp Val Leu Ser Asp Val Gly Asn Leu Thr Ile Val 230 235 240 245 gaa gcc acc aac ctc act ggc att gtg ctg tcc gga ttg ttg ctg ccg 883 Glu Ala Thr Asn Leu Thr Gly Ile Val Leu Ser Gly Leu Leu Leu Pro 250 255 260 tta gct gtt gca ctg att gca tgg cgg atg atc aac aat cgt gga ctg 931 Leu Ala Val Ala Leu Ile Ala Trp Arg Met Ile Asn Asn Arg Gly Leu 265 270 275 acc gcg cag att ggt gcg ggc ttt gct gga ctg atc acc att gcc tct 979 Thr Ala Gln Ile Gly Ala Gly Phe Ala Gly Leu Ile Thr Ile Ala Ser 280 285 290 ccg gta ctg ttc tgg gtt ggt aac tac gtg ggt gcg tgg cct tat gtt 1027 Pro Val Leu Phe Trp Val Gly Asn Tyr Val Gly Ala Trp Pro Tyr Val 295 300 305 gct gcg atc ggt gct tca ggt gtg gtg ctt gcg ctg ttt atg tcc act 1075 Ala Ala Ile Gly Ala Ser Gly Val Val Leu Ala Leu Phe Met Ser Thr 310 315 320 325 ccg tct gtg ccg gta aga atc ttt gcc gca gca ttg gcg ttc atg ggt 1123 Pro Ser Val Pro Val Arg Ile Phe Ala Ala Ala Leu Ala Phe Met Gly 330 335 340 atg ttc cag ctg cat cca gcc cca tcc acc atc gtg atc atg gtg ttg 1171 Met Phe Gln Leu His Pro Ala Pro Ser Thr Ile Val Ile Met Val Leu 345 350 355 ctg ctg tgg tgg ctg ctc aaa ctc gtg gtg gtt cca agc cag aaa gtg 1219 Leu Leu Trp Trp Leu Leu Lys Leu Val Val Val Pro Ser Gln Lys Val 360 365 370 aag ggc tgg aag gcg ggc atc ggt atc cgt ttg aag gat gtc ggc atc 1267 Lys Gly Trp Lys Ala Gly Ile Gly Ile Arg Leu Lys Asp Val Gly Ile 375 380 385 ctg gcc atc acg ggc atc atc ggt gtg ctc ttc atg ctg cct cag gtg 1315 Leu Ala Ile Thr Gly Ile Ile Gly Val Leu Phe Met Leu Pro Gln Val 390 395 400 405 att tca ggt tcc gaa caa acc gaa gat gtg ctg tca tat tct gct gag 1363 Ile Ser Gly Ser Glu Gln Thr Glu Asp Val Leu Ser Tyr Ser Ala Glu 410 415 420 gaa caa gtc acc cgc agc gag tcc tgg ttg gtg tct att ttc atg gag 1411 Glu Gln Val Thr Arg Ser Glu Ser Trp Leu Val Ser Ile Phe Met Glu 425 430 435 acc cgc cat gtt gat ttc ttc gga aat att gac atc gtc cca gtg ctg 1459 Thr Arg His Val Asp Phe Phe Gly Asn Ile Asp Ile Val Pro Val Leu 440 445 450 gta ttc gca gca atc ggt ggc gtg gtt gct ttg gtg tgg cgc gga aac 1507 Val Phe Ala Ala Ile Gly Gly Val Val Ala Leu Val Trp Arg Gly Asn 455 460 465 ttg tgg gcg ccg gtg ttt tac ttc gcc agc gtt gcg ttg acc gct aac 1555 Leu Trp Ala Pro Val Phe Tyr Phe Ala Ser Val Ala Leu Thr Ala Asn 470 475 480 485 tcg ctg aag cct ttt gaa gag ccg tgg ggt gat tgg ctc aac atc gtg 1603 Ser Leu Lys Pro Phe Glu Glu Pro Trp Gly Asp Trp Leu Asn Ile Val 490 495 500 ggc ggt ctg cat tac tcc aca gga cac cgt ttg atc atg cct gtc gcc 1651 Gly Gly Leu His Tyr Ser Thr Gly His Arg Leu Ile Met Pro Val Ala 505 510 515 atg ttc act ttt gct gcc gca ggt atc ggc gct gcc gca gtg atc cgt 1699 Met Phe Thr Phe Ala Ala Ala Gly Ile Gly Ala Ala Ala Val Ile Arg 520 525 530 ttg atc tgc ttg gga cca ata aag aag ttc acc act gtt tcc ggt gtt 1747 Leu Ile Cys Leu Gly Pro Ile Lys Lys Phe Thr Thr Val Ser Gly Val 535 540 545 gtt tct gtg gtg atg gct ctt gtt gtg gct gtg cca ttg cag act tgg 1795 Val Ser Val Val Met Ala Leu Val Val Ala Val Pro Leu Gln Thr Trp 550 555 560 565 gcg aag gat ttt gta gag gaa gga tcc gaa acc aca atc ctt gcg cca 1843 Ala Lys Asp Phe Val Glu Glu Gly Ser Glu Thr Thr Ile Leu Ala Pro 570 575 580 cac aat gat gaa cgt atg gtg agc aac aac gac ttg gct gcc tgg gac 1891 His Asn Asp Glu Arg Met Val Ser Asn Asn Asp Leu Ala Ala Trp Asp 585 590 595 tgg tta atc caa cag cca ggt gga gct gac atg aac atc atg ggt gac 1939 Trp Leu Ile Gln Gln Pro Gly Gly Ala Asp Met Asn Ile Met Gly Asp 600 605 610 ccc gca gat ggt aac ggc tgg atg tat gcc tac aac ggc ttg cac tcc 1987 Pro Ala Asp Gly Asn Gly Trp Met Tyr Ala Tyr Asn Gly Leu His Ser 615 620 625 gtg gcc cgc cac tat gca tgg cca gca gca ggc gaa ggc tct gcc acc 2035 Val Ala Arg His Tyr Ala Trp Pro Ala Ala Gly Glu Gly Ser Ala Thr 630 635 640 645 gcg atg ctg ttc tgg tgg cct caa ctt cta ggt gtg ggc acc gat gaa 2083 Ala Met Leu Phe Trp Trp Pro Gln Leu Leu Gly Val Gly Thr Asp Glu 650 655 660 aac cca gat caa gtc aac gat gtg gat cag gct gct cgt gat ctc aac 2131 Asn Pro Asp Gln Val Asn Asp Val Asp Gln Ala Ala Arg Asp Leu Asn 665 670 675 gtc ggc tac ttc atg atc agt ccg tgg acg ttc tgg gat ttc cag atc 2179 Val Gly Tyr Phe Met Ile Ser Pro Trp Thr Phe Trp Asp Phe Gln Ile 680 685 690 ccc aac ttc cgc cag atc gat ctg ctg tgg caa acc cca ggc gtg aca 2227 Pro Asn Phe Arg Gln Ile Asp Leu Leu Trp Gln Thr Pro Gly Val Thr 695 700 705 ccg gtg tac aag aag ggc gac tcg gtg atc ttc gca gtc aac gat atg 2275 Pro Val Tyr Lys Lys Gly Asp Ser Val Ile Phe Ala Val Asn Asp Met 710 715 720 725 ttc act gac gcc gaa ctg gat cag atg cgt gca cct ggt aat tct cca 2323 Phe Thr Asp Ala Glu Leu Asp Gln Met Arg Ala Pro Gly Asn Ser Pro 730 735 740 gaa cca ctg cca gag ctt cct acc ttg ggc gag ctt ggg ttg gct gaa 2371 Glu Pro Leu Pro Glu Leu Pro Thr Leu Gly Glu Leu Gly Leu Ala Glu 745 750 755 act gaa gac gag gta gat cag act tat tac cat cgt cca acg gtt cct 2419 Thr Glu Asp Glu Val Asp Gln Thr Tyr Tyr His Arg Pro Thr Val Pro 760 765 770 gct ggt gtg aac tca gag atg cct tca gcc gaa act ctg tat gca ccg 2467 Ala Gly Val Asn Ser Glu Met Pro Ser Ala Glu Thr Leu Tyr Ala Pro 775 780 785 gat cca acg aag ccg cat acg gtc cct aac taatcacaaa gagtattcag 2517 Asp Pro Thr Lys Pro His Thr Val Pro Asn 790 795 taaatcgacc 2527 <210> 142 <211> 799 <212> PRT <213> Corynebacterium glutamicum <400> 142 Met Leu Thr Thr Leu Trp Ile Ala Val Leu Val Phe Thr Val Pro Gly 1 5 10 15 Leu Val Val Ser Trp Val Ser Gly Leu Lys Val Pro Trp Ala Ile Ala 20 25 30 Ala Ser Ile Pro Ala Thr Phe Gly Ile Tyr Gly Leu Ser Ala Trp Leu 35 40 45 Leu Gly Leu Trp Glu Met Arg Phe Asp Leu His Ser Val Val Ile Ser 50 55 60 Thr Leu Val Phe Ala Ala Val Ala Leu Val Trp Arg Leu Phe Phe Val 65 70 75 80 Gly Gly Trp Leu Val Arg Arg Arg Lys Ala Arg Ile Arg Arg Gln Thr 85 90 95 Leu Ala Asp Glu Glu Arg Ala Glu Asn Ala Glu Val Ser Ala Gly Glu 100 105 110 Pro Ala Glu Ser Ser Thr Asn Glu Ala Ala Glu Ser Glu Ser Glu Thr 115 120 125 Ser Glu Arg Arg Gly Ile Trp Arg Val Ile Phe Asp Tyr Met Arg Asp 130 135 140 Gly Gly Ile Leu Asp His Arg Trp Leu Leu Pro Ala Ala Gly Ala Ile 145 150 155 160 Thr Gly Ala Trp Leu Ile Ile Asp Arg Ala Val Asp Leu Leu Leu Ser 165 170 175 Thr Glu His Gly Leu Gly Asp Ile Val Gln Gly Trp Asp Val His Trp 180 185 190 His Ala Ser Thr Val Arg Phe Ile Asp Glu Thr Gly Ile Ala Ser Ser 195 200 205 Thr Met Met Gly Gln Leu Arg Asn Ile Glu Thr Gln Gln Asp Leu Phe 210 215 220 Tyr Pro Ser Ala Trp His Ala Gly Ala Trp Val Leu Ser Asp Val Gly 225 230 235 240 Asn Leu Thr Ile Val Glu Ala Thr Asn Leu Thr Gly Ile Val Leu Ser 245 250 255 Gly Leu Leu Leu Pro Leu Ala Val Ala Leu Ile Ala Trp Arg Met Ile 260 265 270 Asn Asn Arg Gly Leu Thr Ala Gln Ile Gly Ala Gly Phe Ala Gly Leu 275 280 285 Ile Thr Ile Ala Ser Pro Val Leu Phe Trp Val Gly Asn Tyr Val Gly 290 295 300 Ala Trp Pro Tyr Val Ala Ala Ile Gly Ala Ser Gly Val Val Leu Ala 305 310 315 320 Leu Phe Met Ser Thr Pro Ser Val Pro Val Arg Ile Phe Ala Ala Ala 325 330 335 Leu Ala Phe Met Gly Met Phe Gln Leu His Pro Ala Pro Ser Thr Ile 340 345 350 Val Ile Met Val Leu Leu Leu Trp Trp Leu Leu Lys Leu Val Val Val 355 360 365 Pro Ser Gln Lys Val Lys Gly Trp Lys Ala Gly Ile Gly Ile Arg Leu 370 375 380 Lys Asp Val Gly Ile Leu Ala Ile Thr Gly Ile Ile Gly Val Leu Phe 385 390 395 400 Met Leu Pro Gln Val Ile Ser Gly Ser Glu Gln Thr Glu Asp Val Leu 405 410 415 Ser Tyr Ser Ala Glu Glu Gln Val Thr Arg Ser Glu Ser Trp Leu Val 420 425 430 Ser Ile Phe Met Glu Thr Arg His Val Asp Phe Phe Gly Asn Ile Asp 435 440 445 Ile Val Pro Val Leu Val Phe Ala Ala Ile Gly Gly Val Val Ala Leu 450 455 460 Val Trp Arg Gly Asn Leu Trp Ala Pro Val Phe Tyr Phe Ala Ser Val 465 470 475 480 Ala Leu Thr Ala Asn Ser Leu Lys Pro Phe Glu Glu Pro Trp Gly Asp 485 490 495 Trp Leu Asn Ile Val Gly Gly Leu His Tyr Ser Thr Gly His Arg Leu 500 505 510 Ile Met Pro Val Ala Met Phe Thr Phe Ala Ala Ala Gly Ile Gly Ala 515 520 525 Ala Ala Val Ile Arg Leu Ile Cys Leu Gly Pro Ile Lys Lys Phe Thr 530 535 540 Thr Val Ser Gly Val Val Ser Val Val Met Ala Leu Val Val Ala Val 545 550 555 560 Pro Leu Gln Thr Trp Ala Lys Asp Phe Val Glu Glu Gly Ser Glu Thr 565 570 575 Thr Ile Leu Ala Pro His Asn Asp Glu Arg Met Val Ser Asn Asn Asp 580 585 590 Leu Ala Ala Trp Asp Trp Leu Ile Gln Gln Pro Gly Gly Ala Asp Met 595 600 605 Asn Ile Met Gly Asp Pro Ala Asp Gly Asn Gly Trp Met Tyr Ala Tyr 610 615 620 Asn Gly Leu His Ser Val Ala Arg His Tyr Ala Trp Pro Ala Ala Gly 625 630 635 640 Glu Gly Ser Ala Thr Ala Met Leu Phe Trp Trp Pro Gln Leu Leu Gly 645 650 655 Val Gly Thr Asp Glu Asn Pro Asp Gln Val Asn Asp Val Asp Gln Ala 660 665 670 Ala Arg Asp Leu Asn Val Gly Tyr Phe Met Ile Ser Pro Trp Thr Phe 675 680 685 Trp Asp Phe Gln Ile Pro Asn Phe Arg Gln Ile Asp Leu Leu Trp Gln 690 695 700 Thr Pro Gly Val Thr Pro Val Tyr Lys Lys Gly Asp Ser Val Ile Phe 705 710 715 720 Ala Val Asn Asp Met Phe Thr Asp Ala Glu Leu Asp Gln Met Arg Ala 725 730 735 Pro Gly Asn Ser Pro Glu Pro Leu Pro Glu Leu Pro Thr Leu Gly Glu 740 745 750 Leu Gly Leu Ala Glu Thr Glu Asp Glu Val Asp Gln Thr Tyr Tyr His 755 760 765 Arg Pro Thr Val Pro Ala Gly Val Asn Ser Glu Met Pro Ser Ala Glu 770 775 780 Thr Leu Tyr Ala Pro Asp Pro Thr Lys Pro His Thr Val Pro Asn 785 790 795 <210> 143 <211> 1777 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1747) <223> RXA01400 <400> 143 cgccggggac ggggaaggcg ctgtgttgta ggggagagtt catggaaact tcctaaatta 60 ttttctatca atctatagat actaggtcta ttatagtgcc atg aga ctg aca cat 115 Met Arg Leu Thr His 1 5 gta gac caa tta aac ctt ccg ttt ggc acg ttg agc agc tat cac cct 163 Val Asp Gln Leu Asn Leu Pro Phe Gly Thr Leu Ser Ser Tyr His Pro 10 15 20 tat gca tcg gct ccg ggt gag gcg gtg ccg gtg tcc ttt gat cag caa 211 Tyr Ala Ser Ala Pro Gly Glu Ala Val Pro Val Ser Phe Asp Gln Gln 25 30 35 cga cat gtg ggt gcc ggc gag cga ccg ggt agt tgg atg gcg att agt 259 Arg His Val Gly Ala Gly Glu Arg Pro Gly Ser Trp Met Ala Ile Ser 40 45 50 gtt tct atg cct aag gcg atc agc cgt gag gaa ttg gag cgc gcg tgg 307 Val Ser Met Pro Lys Ala Ile Ser Arg Glu Glu Leu Glu Arg Ala Trp 55 60 65 ctt gaa gtg att gaa cgg cac ggc acc ttg cgc aca gta ttt agc acg 355 Leu Glu Val Ile Glu Arg His Gly Thr Leu Arg Thr Val Phe Ser Thr 70 75 80 85 gga atg ggt ggg gaa gtg cag caa cac cgc att gat gtg ggc ccg gga 403 Gly Met Gly Gly Glu Val Gln Gln His Arg Ile Asp Val Gly Pro Gly 90 95 100 aaa tgg att gac cac gcc gtt gcg cct ggt gag agc att aat gag gcg 451 Lys Trp Ile Asp His Ala Val Ala Pro Gly Glu Ser Ile Asn Glu Ala 105 110 115 ttg cgg gcg gtg ttg aat cgg cag tgt tcg ccg tac tcg agg cca tcg 499 Leu Arg Ala Val Leu Asn Arg Gln Cys Ser Pro Tyr Ser Arg Pro Ser 120 125 130 cat agt ttg tgc att att gat gcg cat ccg cgt ccc acg gtg att att 547 His Ser Leu Cys Ile Ile Asp Ala His Pro Arg Pro Thr Val Ile Ile 135 140 145 ggt agt gat cat tcg cat gtg gat atg tgg tcc atg ctg gtg att gtg 595 Gly Ser Asp His Ser His Val Asp Met Trp Ser Met Leu Val Ile Val 150 155 160 165 cgc gat ttg ttg gct gcg ctc gat atg gaa ctt ccc gtt gag ccg ccg 643 Arg Asp Leu Leu Ala Ala Leu Asp Met Glu Leu Pro Val Glu Pro Pro 170 175 180 ttg gcg ttt gaa tcg cac acc gcg gaa ctc ctc gcg gct cca cct gca 691 Leu Ala Phe Glu Ser His Thr Ala Glu Leu Leu Ala Ala Pro Pro Ala 185 190 195 ccg gag cgg att cac cag cgg tgg cgt gaa att ttg gaa gct ggt ggt 739 Pro Glu Arg Ile His Gln Arg Trp Arg Glu Ile Leu Glu Ala Gly Gly 200 205 210 gga aaa atg cct cag ttc ccg ctt ccg ctt ggc gat gcc atc tcc atg 787 Gly Lys Met Pro Gln Phe Pro Leu Pro Leu Gly Asp Ala Ile Ser Met 215 220 225 cct gaa cgc gtt gaa gtc cgc gac att ttc ggg gtc aat ggc ttg gcg 835 Pro Glu Arg Val Glu Val Arg Asp Ile Phe Gly Val Asn Gly Leu Ala 230 235 240 245 att tac tcg gca cgc gcc cgc gca caa cag gta agc tcc ctg gcc ttg 883 Ile Tyr Ser Ala Arg Ala Arg Ala Gln Gln Val Ser Ser Leu Ala Leu 250 255 260 act att tca gtg atg gct gat gtt acg gcg gcg ctg gcg gac ctt ccg 931 Thr Ile Ser Val Met Ala Asp Val Thr Ala Ala Leu Ala Asp Leu Pro 265 270 275 ttg cgt gct gta ttc cca gtc cat agc cgt ttc gat cag cgc tgg cac 979 Leu Arg Ala Val Phe Pro Val His Ser Arg Phe Asp Gln Arg Trp His 280 285 290 gat agt gtc ggg tgg ttt atc tcc aat tcg gtc att gag gtg cca gat 1027 Asp Ser Val Gly Trp Phe Ile Ser Asn Ser Val Ile Glu Val Pro Asp 295 300 305 tcc gat cct cac act gca gcc caa gct gtt cgc gag gct gtt tct ttg 1075 Ser Asp Pro His Thr Ala Ala Gln Ala Val Arg Glu Ala Val Ser Leu 310 315 320 325 gga agc tac ccg ctg gct gag ctg ctt gaa ccg tgg ggt ggc atg ccg 1123 Gly Ser Tyr Pro Leu Ala Glu Leu Leu Glu Pro Trp Gly Gly Met Pro 330 335 340 gaa acg cca gga atg ttt gct att tct tgg ctt gac ctg cgc cga ctc 1171 Glu Thr Pro Gly Met Phe Ala Ile Ser Trp Leu Asp Leu Arg Arg Leu 345 350 355 cca gtg agc att gac gat att ggc ctc caa gcc cag tat gtc agc gct 1219 Pro Val Ser Ile Asp Asp Ile Gly Leu Gln Ala Gln Tyr Val Ser Ala 360 365 370 tca ctg cgc acc gat ggt gtg atg ctg tgg ttt att ttg gat cgc tcc 1267 Ser Leu Arg Thr Asp Gly Val Met Leu Trp Phe Ile Leu Asp Arg Ser 375 380 385 ggc gcg cac ctt cgc tgt cgt tat cct gac tct ttg gtg gcg cgg gaa 1315 Gly Ala His Leu Arg Cys Arg Tyr Pro Asp Ser Leu Val Ala Arg Glu 390 395 400 405 aat gta ggc cgc tgg att gat gcg att gtt gct cag atg cgc gcc gaa 1363 Asn Val Gly Arg Trp Ile Asp Ala Ile Val Ala Gln Met Arg Ala Glu 410 415 420 gct ggg acg gtg aat ctg cag gcc ggc ggg gaa cag ctg aca ctt cgg 1411 Ala Gly Thr Val Asn Leu Gln Ala Gly Gly Glu Gln Leu Thr Leu Arg 425 430 435 cat gga act cgc gcc gat att tcc gag atc gcc ccg cta ctt gcc cga 1459 His Gly Thr Arg Ala Asp Ile Ser Glu Ile Ala Pro Leu Leu Ala Arg 440 445 450 aac gca gct gac cct tgt gag ctg gtg gat ctt gaa cat gcc ctt gac 1507 Asn Ala Ala Asp Pro Cys Glu Leu Val Asp Leu Glu His Ala Leu Asp 455 460 465 ctg ctg aca cac gag tct tcg cat ttc ctg gcg gtg gtt cga aac gct 1555 Leu Leu Thr His Glu Ser Ser His Phe Leu Ala Val Val Arg Asn Ala 470 475 480 485 cgt ggc aag ata atc gca gcg atg cag ttg act att gtt ccg gag ttt 1603 Arg Gly Lys Ile Ile Ala Ala Met Gln Leu Thr Ile Val Pro Glu Phe 490 495 500 tcc cgc ggt ggt gcg ctt cat ctt cac atc gag ggg ccg ttc att att 1651 Ser Arg Gly Gly Ala Leu His Leu His Ile Glu Gly Pro Phe Ile Ile 505 510 515 ccg gaa tat cgc acc acc gat ttg gat aaa aag ctg cgc gcc tgg gct 1699 Pro Glu Tyr Arg Thr Thr Asp Leu Asp Lys Lys Leu Arg Ala Trp Ala 520 525 530 gtg gag cat ggg cgt gcg cga ggg gtg aag gtt gag gag gtg gtg gga 1747 Val Glu His Gly Arg Ala Arg Gly Val Lys Val Glu Glu Val Val Gly 535 540 545 tagttggttt attggcgcct cgttgtggaa 1777 <210> 144 <211> 549 <212> PRT <213> Corynebacterium glutamicum <400> 144 Met Arg Leu Thr His Val Asp Gln Leu Asn Leu Pro Phe Gly Thr Leu 1 5 10 15 Ser Ser Tyr His Pro Tyr Ala Ser Ala Pro Gly Glu Ala Val Pro Val 20 25 30 Ser Phe Asp Gln Gln Arg His Val Gly Ala Gly Glu Arg Pro Gly Ser 35 40 45 Trp Met Ala Ile Ser Val Ser Met Pro Lys Ala Ile Ser Arg Glu Glu 50 55 60 Leu Glu Arg Ala Trp Leu Glu Val Ile Glu Arg His Gly Thr Leu Arg 65 70 75 80 Thr Val Phe Ser Thr Gly Met Gly Gly Glu Val Gln Gln His Arg Ile 85 90 95 Asp Val Gly Pro Gly Lys Trp Ile Asp His Ala Val Ala Pro Gly Glu 100 105 110 Ser Ile Asn Glu Ala Leu Arg Ala Val Leu Asn Arg Gln Cys Ser Pro 115 120 125 Tyr Ser Arg Pro Ser His Ser Leu Cys Ile Ile Asp Ala His Pro Arg 130 135 140 Pro Thr Val Ile Ile Gly Ser Asp His Ser His Val Asp Met Trp Ser 145 150 155 160 Met Leu Val Ile Val Arg Asp Leu Leu Ala Ala Leu Asp Met Glu Leu 165 170 175 Pro Val Glu Pro Pro Leu Ala Phe Glu Ser His Thr Ala Glu Leu Leu 180 185 190 Ala Ala Pro Pro Ala Pro Glu Arg Ile His Gln Arg Trp Arg Glu Ile 195 200 205 Leu Glu Ala Gly Gly Gly Lys Met Pro Gln Phe Pro Leu Pro Leu Gly 210 215 220 Asp Ala Ile Ser Met Pro Glu Arg Val Glu Val Arg Asp Ile Phe Gly 225 230 235 240 Val Asn Gly Leu Ala Ile Tyr Ser Ala Arg Ala Arg Ala Gln Gln Val 245 250 255 Ser Ser Leu Ala Leu Thr Ile Ser Val Met Ala Asp Val Thr Ala Ala 260 265 270 Leu Ala Asp Leu Pro Leu Arg Ala Val Phe Pro Val His Ser Arg Phe 275 280 285 Asp Gln Arg Trp His Asp Ser Val Gly Trp Phe Ile Ser Asn Ser Val 290 295 300 Ile Glu Val Pro Asp Ser Asp Pro His Thr Ala Ala Gln Ala Val Arg 305 310 315 320 Glu Ala Val Ser Leu Gly Ser Tyr Pro Leu Ala Glu Leu Leu Glu Pro 325 330 335 Trp Gly Gly Met Pro Glu Thr Pro Gly Met Phe Ala Ile Ser Trp Leu 340 345 350 Asp Leu Arg Arg Leu Pro Val Ser Ile Asp Asp Ile Gly Leu Gln Ala 355 360 365 Gln Tyr Val Ser Ala Ser Leu Arg Thr Asp Gly Val Met Leu Trp Phe 370 375 380 Ile Leu Asp Arg Ser Gly Ala His Leu Arg Cys Arg Tyr Pro Asp Ser 385 390 395 400 Leu Val Ala Arg Glu Asn Val Gly Arg Trp Ile Asp Ala Ile Val Ala 405 410 415 Gln Met Arg Ala Glu Ala Gly Thr Val Asn Leu Gln Ala Gly Gly Glu 420 425 430 Gln Leu Thr Leu Arg His Gly Thr Arg Ala Asp Ile Ser Glu Ile Ala 435 440 445 Pro Leu Leu Ala Arg Asn Ala Ala Asp Pro Cys Glu Leu Val Asp Leu 450 455 460 Glu His Ala Leu Asp Leu Leu Thr His Glu Ser Ser His Phe Leu Ala 465 470 475 480 Val Val Arg Asn Ala Arg Gly Lys Ile Ile Ala Ala Met Gln Leu Thr 485 490 495 Ile Val Pro Glu Phe Ser Arg Gly Gly Ala Leu His Leu His Ile Glu 500 505 510 Gly Pro Phe Ile Ile Pro Glu Tyr Arg Thr Thr Asp Leu Asp Lys Lys 515 520 525 Leu Arg Ala Trp Ala Val Glu His Gly Arg Ala Arg Gly Val Lys Val 530 535 540 Glu Glu Val Val Gly 545 <210> 145 <211> 1081 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1051) <223> RXA01425 <400> 145 ccggtgccga accatggatt ttggtccacc gaaacggtga catagaagtc ctgccaacaa 60 gtacatagtc cctattaatc ccaaggagtt tcgactcaca gtg ctc aat ttc att 115 Val Leu Asn Phe Ile 1 5 tat tgg cca att tcg gcc att ctg tgg ttc tgg cat aaa gcg ttc agc 163 Tyr Trp Pro Ile Ser Ala Ile Leu Trp Phe Trp His Lys Ala Phe Ser 10 15 20 ttt gtg ctg agc cca gat tcc gga att acc tgg gcc ttg tcg atc atg 211 Phe Val Leu Ser Pro Asp Ser Gly Ile Thr Trp Ala Leu Ser Ile Met 25 30 35 ttc ttg acc ttc acc gtg cgt atg gtt ctg gtc aag ccg atg gtc aac 259 Phe Leu Thr Phe Thr Val Arg Met Val Leu Val Lys Pro Met Val Asn 40 45 50 acc atg cgt tca cag cgc aag atg caa gac atg gct cca aag atg cag 307 Thr Met Arg Ser Gln Arg Lys Met Gln Asp Met Ala Pro Lys Met Gln 55 60 65 gcc atc cgc gag aag tac aaa aat gac cag cag aag atg atg gag gag 355 Ala Ile Arg Glu Lys Tyr Lys Asn Asp Gln Gln Lys Met Met Glu Glu 70 75 80 85 acc cgc aaa ctt caa aaa gaa gtg ggc gtt aac ccc atc gca ggc tgt 403 Thr Arg Lys Leu Gln Lys Glu Val Gly Val Asn Pro Ile Ala Gly Cys 90 95 100 ttg cca atg ttg gtg cag atc cca gtg ttc ctg ggt ctg ttc cac gtg 451 Leu Pro Met Leu Val Gln Ile Pro Val Phe Leu Gly Leu Phe His Val 105 110 115 ctg cgc tcc ttc aac cgc acc ggt tct ggc gtt ggc cag ctg gaa atg 499 Leu Arg Ser Phe Asn Arg Thr Gly Ser Gly Val Gly Gln Leu Glu Met 120 125 130 acc gtt gag caa aac gcg aac acc ccg aac tac atc ttc ggt gtc gac 547 Thr Val Glu Gln Asn Ala Asn Thr Pro Asn Tyr Ile Phe Gly Val Asp 135 140 145 gag gtt cag tcc ttc ctg cgt gca gac ctg ttc ggt gcg cca ctg tcg 595 Glu Val Gln Ser Phe Leu Arg Ala Asp Leu Phe Gly Ala Pro Leu Ser 150 155 160 165 tcc tac atc acc atg cct gct gac gcg ttc gac gcg ttc ctt ggc ctg 643 Ser Tyr Ile Thr Met Pro Ala Asp Ala Phe Asp Ala Phe Leu Gly Leu 170 175 180 gat gtc tcc cgc ctc aac atc gcg ctg gtt gca gct cca atg att ttg 691 Asp Val Ser Arg Leu Asn Ile Ala Leu Val Ala Ala Pro Met Ile Leu 185 190 195 atc att gtc gtg gca act cac atg aac gcg cgt ctg tcc gtc aac cgc 739 Ile Ile Val Val Ala Thr His Met Asn Ala Arg Leu Ser Val Asn Arg 200 205 210 cag gaa gct cgc aag gca gcc ggc aag cag cag gcc gct tcc agc gat 787 Gln Glu Ala Arg Lys Ala Ala Gly Lys Gln Gln Ala Ala Ser Ser Asp 215 220 225 cag atg gcc atg cag atg caa atg atg aac aag atg atg ctc tgg ttc 835 Gln Met Ala Met Gln Met Gln Met Met Asn Lys Met Met Leu Trp Phe 230 235 240 245 atg cca gcc acc att ttg ttc acc ggc ttc atc tgg acc atc ggt ctt 883 Met Pro Ala Thr Ile Leu Phe Thr Gly Phe Ile Trp Thr Ile Gly Leu 250 255 260 ctt gtc tac atg atg tcc aac aac gtg tgg acc ttc ttc cag cag cgc 931 Leu Val Tyr Met Met Ser Asn Asn Val Trp Thr Phe Phe Gln Gln Arg 265 270 275 tac atc ttc gcc aag atg gac gct gag gaa gca gct gag gag gag gaa 979 Tyr Ile Phe Ala Lys Met Asp Ala Glu Glu Ala Ala Glu Glu Glu Glu 280 285 290 aag cgc gca gca aag cgc act acc gct cca aag cct ggc gtg aag cca 1027 Lys Arg Ala Ala Lys Arg Thr Thr Ala Pro Lys Pro Gly Val Lys Pro 295 300 305 gaa aac ccc aag aag cgt aag aag taaaacttca ctaaaaaccg ccagcccacg 1081 Glu Asn Pro Lys Lys Arg Lys Lys 310 315 <210> 146 <211> 317 <212> PRT <213> Corynebacterium glutamicum <400> 146 Val Leu Asn Phe Ile Tyr Trp Pro Ile Ser Ala Ile Leu Trp Phe Trp 1 5 10 15 His Lys Ala Phe Ser Phe Val Leu Ser Pro Asp Ser Gly Ile Thr Trp 20 25 30 Ala Leu Ser Ile Met Phe Leu Thr Phe Thr Val Arg Met Val Leu Val 35 40 45 Lys Pro Met Val Asn Thr Met Arg Ser Gln Arg Lys Met Gln Asp Met 50 55 60 Ala Pro Lys Met Gln Ala Ile Arg Glu Lys Tyr Lys Asn Asp Gln Gln 65 70 75 80 Lys Met Met Glu Glu Thr Arg Lys Leu Gln Lys Glu Val Gly Val Asn 85 90 95 Pro Ile Ala Gly Cys Leu Pro Met Leu Val Gln Ile Pro Val Phe Leu 100 105 110 Gly Leu Phe His Val Leu Arg Ser Phe Asn Arg Thr Gly Ser Gly Val 115 120 125 Gly Gln Leu Glu Met Thr Val Glu Gln Asn Ala Asn Thr Pro Asn Tyr 130 135 140 Ile Phe Gly Val Asp Glu Val Gln Ser Phe Leu Arg Ala Asp Leu Phe 145 150 155 160 Gly Ala Pro Leu Ser Ser Tyr Ile Thr Met Pro Ala Asp Ala Phe Asp 165 170 175 Ala Phe Leu Gly Leu Asp Val Ser Arg Leu Asn Ile Ala Leu Val Ala 180 185 190 Ala Pro Met Ile Leu Ile Ile Val Val Ala Thr His Met Asn Ala Arg 195 200 205 Leu Ser Val Asn Arg Gln Glu Ala Arg Lys Ala Ala Gly Lys Gln Gln 210 215 220 Ala Ala Ser Ser Asp Gln Met Ala Met Gln Met Gln Met Met Asn Lys 225 230 235 240 Met Met Leu Trp Phe Met Pro Ala Thr Ile Leu Phe Thr Gly Phe Ile 245 250 255 Trp Thr Ile Gly Leu Leu Val Tyr Met Met Ser Asn Asn Val Trp Thr 260 265 270 Phe Phe Gln Gln Arg Tyr Ile Phe Ala Lys Met Asp Ala Glu Glu Ala 275 280 285 Ala Glu Glu Glu Glu Lys Arg Ala Ala Lys Arg Thr Thr Ala Pro Lys 290 295 300 Pro Gly Val Lys Pro Glu Asn Pro Lys Lys Arg Lys Lys 305 310 315 <210> 147 <211> 3457 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3427) <223> RXA01434 <400> 147 acgggatcgc ccaaaccgcc accaacccac taacgtatcg catagttatt ttcgccgtgc 60 tcgccgttaa ggcgcgcact cgtacatgaa tggtcaacaa gtg agt tct tcg ctt 115 Val Ser Ser Ser Leu 1 5 tcg aat aat tcg gag cag tcc ggc ctg cgt ggc agg atc gtt gct cca 163 Ser Asn Asn Ser Glu Gln Ser Gly Leu Arg Gly Arg Ile Val Ala Pro 10 15 20 gca ccg ccg gcg cct gtg ccc gag gcg cgc aag aag gct gtc gca cgc 211 Ala Pro Pro Ala Pro Val Pro Glu Ala Arg Lys Lys Ala Val Ala Arg 25 30 35 acg gat ggt gat cgc tcg agt ttg aaa aac tcg cct acg gca tcc gcc 259 Thr Asp Gly Asp Arg Ser Ser Leu Lys Asn Ser Pro Thr Ala Ser Ala 40 45 50 acc cag gca gcc cag acg cgc ccg gca gaa ccg gaa cca aaa aag cac 307 Thr Gln Ala Ala Gln Thr Arg Pro Ala Glu Pro Glu Pro Lys Lys His 55 60 65 acc tcc gat tct gat gtg gtg cgc tcg act ggc tcc atg gca ata gcc 355 Thr Ser Asp Ser Asp Val Val Arg Ser Thr Gly Ser Met Ala Ile Ala 70 75 80 85 acg ctg ctg agt cgt atc acc ggt ttc ctg cgc acc gtg atg att ggt 403 Thr Leu Leu Ser Arg Ile Thr Gly Phe Leu Arg Thr Val Met Ile Gly 90 95 100 gcg gcg ctg tcg ccg gcc atc gct tcg gcg ttc aac act gcc aac acg 451 Ala Ala Leu Ser Pro Ala Ile Ala Ser Ala Phe Asn Thr Ala Asn Thr 105 110 115 ctg ccc aac ctg atc act gaa atc gtg ttg ggt gcg gtg ctg aca tcg 499 Leu Pro Asn Leu Ile Thr Glu Ile Val Leu Gly Ala Val Leu Thr Ser 120 125 130 ctg gtt att ccg gtc ctt acc cgc gcg gaa aaa gaa gac gcc gac ggc 547 Leu Val Ile Pro Val Leu Thr Arg Ala Glu Lys Glu Asp Ala Asp Gly 135 140 145 ggt tcc ggg ttc ttc agg cgg ctg ctc acc ctg tcg gtg acg ctg ctg 595 Gly Ser Gly Phe Phe Arg Arg Leu Leu Thr Leu Ser Val Thr Leu Leu 150 155 160 165 ggt ggt gtc acc atc ctg tcg att atc ggc gcg ccg ctg ctg aca cgg 643 Gly Gly Val Thr Ile Leu Ser Ile Ile Gly Ala Pro Leu Leu Thr Arg 170 175 180 atg atg ctg tcc tct gag gga caa gtc aac gtg gtc atg tcc acg gcc 691 Met Met Leu Ser Ser Glu Gly Gln Val Asn Val Val Met Ser Thr Ala 185 190 195 ttt gcg tat tgg ctg ctg cca cag att ttc ttc tac ggc ctg ttt gcc 739 Phe Ala Tyr Trp Leu Leu Pro Gln Ile Phe Phe Tyr Gly Leu Phe Ala 200 205 210 ctg ttc atg gct gtg ttg aac acc cgt gaa gtg ttc aaa ccc ggc gcg 787 Leu Phe Met Ala Val Leu Asn Thr Arg Glu Val Phe Lys Pro Gly Ala 215 220 225 tgg gca cct gtt gtc aac aat gtg atc acc ttg acc gtg ctg ggc gtg 835 Trp Ala Pro Val Val Asn Asn Val Ile Thr Leu Thr Val Leu Gly Val 230 235 240 245 tac atg gtg ctg cct gcg cgt ttg cac ccg cat gag cag gtg ggc att 883 Tyr Met Val Leu Pro Ala Arg Leu His Pro His Glu Gln Val Gly Ile 250 255 260 ttt gat ccg cag atc att ttc ctc ggc gtg ggc acc acc ctt ggt gtg 931 Phe Asp Pro Gln Ile Ile Phe Leu Gly Val Gly Thr Thr Leu Gly Val 265 270 275 gtt gca cag tgt cta atc atg att ccg tac ctg cgt cgc gcg ggc att 979 Val Ala Gln Cys Leu Ile Met Ile Pro Tyr Leu Arg Arg Ala Gly Ile 280 285 290 gat atg cgc cct ctg tgg ggt atc gat gcg cgt ttg aag caa ttc ggt 1027 Asp Met Arg Pro Leu Trp Gly Ile Asp Ala Arg Leu Lys Gln Phe Gly 295 300 305 ggc atg gcg atg gcg atc atc gtg tac gtg gca atc tcc cag ttc ggt 1075 Gly Met Ala Met Ala Ile Ile Val Tyr Val Ala Ile Ser Gln Phe Gly 310 315 320 325 tac atc atc acc act cgc att gcg tcg att gca gac gat gct gcg ccg 1123 Tyr Ile Ile Thr Thr Arg Ile Ala Ser Ile Ala Asp Asp Ala Ala Pro 330 335 340 ttt att tat cag cag cac tgg atg ttg ctg caa gtt cct tat ggc atc 1171 Phe Ile Tyr Gln Gln His Trp Met Leu Leu Gln Val Pro Tyr Gly Ile 345 350 355 atc ggc gtc acc ttg ctc acc gcg att atg ccg cga ctg tcc cgc aac 1219 Ile Gly Val Thr Leu Leu Thr Ala Ile Met Pro Arg Leu Ser Arg Asn 360 365 370 gcg gca gac ggc gat gat agg gca gta gtc tct gac ctt cag ttg ggt 1267 Ala Ala Asp Gly Asp Asp Arg Ala Val Val Ser Asp Leu Gln Leu Gly 375 380 385 tcc aag cta acc ttc atc gca ctg atc ccc atc gtg gtg ttc ttc acc 1315 Ser Lys Leu Thr Phe Ile Ala Leu Ile Pro Ile Val Val Phe Phe Thr 390 395 400 405 gcc ttc ggt gtc cct att gcc aat ggc ctt ttt gcc tac ggc caa ttc 1363 Ala Phe Gly Val Pro Ile Ala Asn Gly Leu Phe Ala Tyr Gly Gln Phe 410 415 420 gat gcc aac gcc gcc aac atc ctt ggt tgg act ctg agc ttc tct gct 1411 Asp Ala Asn Ala Ala Asn Ile Leu Gly Trp Thr Leu Ser Phe Ser Ala 425 430 435 ttc acg ctg att cct tac gct ttg gtg ctg cta cat ctg cgt gtg ttt 1459 Phe Thr Leu Ile Pro Tyr Ala Leu Val Leu Leu His Leu Arg Val Phe 440 445 450 tat gcg cgt gaa gag gtc tgg acc cca acc ttc atc atc gcc ggc atc 1507 Tyr Ala Arg Glu Glu Val Trp Thr Pro Thr Phe Ile Ile Ala Gly Ile 455 460 465 acc gcc acc aag gtc gtg ctt tcc ctg ttg gca ccg ctg ctg tcg agc 1555 Thr Ala Thr Lys Val Val Leu Ser Leu Leu Ala Pro Leu Leu Ser Ser 470 475 480 485 tcc ccg gag cgt gtg gtg gtg ctt ctt ggt gcg gcc aac ggt ttc agt 1603 Ser Pro Glu Arg Val Val Val Leu Leu Gly Ala Ala Asn Gly Phe Ser 490 495 500 ttc atc acc ggc gcg gtc atc ggc gcg tat ctg ttg cgc aac aaa ctc 1651 Phe Ile Thr Gly Ala Val Ile Gly Ala Tyr Leu Leu Arg Asn Lys Leu 505 510 515 ggc ctg ttg ggt atg cgc tct ttg gct aaa acc tcc ctg tgg gcg ttg 1699 Gly Leu Leu Gly Met Arg Ser Leu Ala Lys Thr Ser Leu Trp Ala Leu 520 525 530 ggc tct gcg gcg gtt ggt gca gca gca gca tgg gcg ttg ggg tgg ctg 1747 Gly Ser Ala Ala Val Gly Ala Ala Ala Ala Trp Ala Leu Gly Trp Leu 535 540 545 att caa gcc gtc gtg ggc gat ttc ttg ctg ggc act cta agc tcc gta 1795 Ile Gln Ala Val Val Gly Asp Phe Leu Leu Gly Thr Leu Ser Ser Val 550 555 560 565 ggc tac ttg ttg aac ctg gct gtg ttg ggt gtc ttc ttc atc ttc gtc 1843 Gly Tyr Leu Leu Asn Leu Ala Val Leu Gly Val Phe Phe Ile Phe Val 570 575 580 acc ggc atc gtg ttg tca cgt tct ggt ttg ccg gag gtc caa aac ttg 1891 Thr Gly Ile Val Leu Ser Arg Ser Gly Leu Pro Glu Val Gln Asn Leu 585 590 595 ggc cag gca ctg acc cgc atc cca ggt ttg agc cgg ttt att cgc ccg 1939 Gly Gln Ala Leu Thr Arg Ile Pro Gly Leu Ser Arg Phe Ile Arg Pro 600 605 610 aat acc aag atc tct ttg gat gtc ggc gaa gtc tcc gag cag gat ttc 1987 Asn Thr Lys Ile Ser Leu Asp Val Gly Glu Val Ser Glu Gln Asp Phe 615 620 625 tcc acc cag ctg gtc gcg cca agc gag ttc gca gca acc cct gtg ccg 2035 Ser Thr Gln Leu Val Ala Pro Ser Glu Phe Ala Ala Thr Pro Val Pro 630 635 640 645 cca ccg atg tcc gcc ggt att gtc cgc gga cct cgc ctg gtt ccc ggc 2083 Pro Pro Met Ser Ala Gly Ile Val Arg Gly Pro Arg Leu Val Pro Gly 650 655 660 gcc cca gtc ggc gac ggt cgt ttc cgt ctg ctc gcc gat cac ggc ggc 2131 Ala Pro Val Gly Asp Gly Arg Phe Arg Leu Leu Ala Asp His Gly Gly 665 670 675 gtc caa ggc gcg cgt ttc tgg cag gcc cgc gag atc gcc acc ggc aag 2179 Val Gln Gly Ala Arg Phe Trp Gln Ala Arg Glu Ile Ala Thr Gly Lys 680 685 690 gaa gtc gcg ctg atc ttt gtg gat act tcc ggc aac gcc cca ttt gcg 2227 Glu Val Ala Leu Ile Phe Val Asp Thr Ser Gly Asn Ala Pro Phe Ala 695 700 705 cca ctg tct tcg gca gcc gca gcg ggc atc gcc tac gag gtg cag cgc 2275 Pro Leu Ser Ser Ala Ala Ala Ala Gly Ile Ala Tyr Glu Val Gln Arg 710 715 720 725 cgc acc aag aag ctg gcc agc ttg ggc agc ttg gcg gta gcc ccc aac 2323 Arg Thr Lys Lys Leu Ala Ser Leu Gly Ser Leu Ala Val Ala Pro Asn 730 735 740 atc cac tcc gag gcg tac cgc aac ggt tgc ctc att gtg gcc gat tgg 2371 Ile His Ser Glu Ala Tyr Arg Asn Gly Cys Leu Ile Val Ala Asp Trp 745 750 755 gtg cct ggc tcc agc ttg agc gcc gtc gcg gaa tcc ggt gcc gat ccc 2419 Val Pro Gly Ser Ser Leu Ser Ala Val Ala Glu Ser Gly Ala Asp Pro 760 765 770 cgc gcc gcc gcg ttc gcg ctc gcg gaa cta act gaa acc atc ggc gag 2467 Arg Ala Ala Ala Phe Ala Leu Ala Glu Leu Thr Glu Thr Ile Gly Glu 775 780 785 gcc cac gag atg ggt atc ccg gcc ggc ttg gac aac aag tgc cgc atc 2515 Ala His Glu Met Gly Ile Pro Ala Gly Leu Asp Asn Lys Cys Arg Ile 790 795 800 805 cgc atc aac acc gac ggc cat gcc gtc ctc gcc ttc ccg gcg att ttg 2563 Arg Ile Asn Thr Asp Gly His Ala Val Leu Ala Phe Pro Ala Ile Leu 810 815 820 ccc gat gcc tca gag ctc cgc gac gcc aag tcc ctg gcc tcg gcc gcc 2611 Pro Asp Ala Ser Glu Leu Arg Asp Ala Lys Ser Leu Ala Ser Ala Ala 825 830 835 gag atg ctt atc gac gcg acc ctc gct ccc agc gac gtc aag gca atg 2659 Glu Met Leu Ile Asp Ala Thr Leu Ala Pro Ser Asp Val Lys Ala Met 840 845 850 gtc act gaa gcc cag ggg cta gct aca gaa gac aat ccc gat tac gca 2707 Val Thr Glu Ala Gln Gly Leu Ala Thr Glu Asp Asn Pro Asp Tyr Ala 855 860 865 tca ctt gcc atg gcg atg cgc acc tgc gga ctg ttc acc gag gaa cca 2755 Ser Leu Ala Met Ala Met Arg Thr Cys Gly Leu Phe Thr Glu Glu Pro 870 875 880 885 acc cac ctt gtg gtg aag aag gaa aag aca cca aag cct gcg aca cgt 2803 Thr His Leu Val Val Lys Lys Glu Lys Thr Pro Lys Pro Ala Thr Arg 890 895 900 gat ggt ttc ggt gcc tcc gac tac acc gtc aag ggc atg gca gcc atc 2851 Asp Gly Phe Gly Ala Ser Asp Tyr Thr Val Lys Gly Met Ala Ala Ile 905 910 915 gcc gct gtg gtg atc atc ttg gtt tcc ctg gtg gcc gcc ggt acc gcg 2899 Ala Ala Val Val Ile Ile Leu Val Ser Leu Val Ala Ala Gly Thr Ala 920 925 930 ttc ctc acc agc ttc ttc ggc agc agc acc aac gaa caa tcc ccg ttg 2947 Phe Leu Thr Ser Phe Phe Gly Ser Ser Thr Asn Glu Gln Ser Pro Leu 935 940 945 gcc tct gtt gaa gcc acc acc tct gca aca cca gaa cct gtg ggg cca 2995 Ala Ser Val Glu Ala Thr Thr Ser Ala Thr Pro Glu Pro Val Gly Pro 950 955 960 965 ccg gtc tac ctg gat ctg gat caa gcc cgc acg tgg gat gac ggt gca 3043 Pro Val Tyr Leu Asp Leu Asp Gln Ala Arg Thr Trp Asp Asp Gly Ala 970 975 980 gga aca gat gtc acc gac gtc acc gac ggc aac acc tcc acc gca tgg 3091 Gly Thr Asp Val Thr Asp Val Thr Asp Gly Asn Thr Ser Thr Ala Trp 985 990 995 acc tcc acc ggc ggc gac ggc ctc cta gtt gac ctg tcc acg cct gcc 3139 Thr Ser Thr Gly Gly Asp Gly Leu Leu Val Asp Leu Ser Thr Pro Ala 1000 1005 1010 cgc ctc gac cgc gtc atc ttg acc acc ggc acc ggc tcc gac agc aac 3187 Arg Leu Asp Arg Val Ile Leu Thr Thr Gly Thr Gly Ser Asp Ser Asn 1015 1020 1025 gtg acc tcg acc gtg aag atc tac gca ttc aac gac gcc tca cca cac 3235 Val Thr Ser Thr Val Lys Ile Tyr Ala Phe Asn Asp Ala Ser Pro His 1030 1035 1040 1045 tcc ctg tcg gaa ggc atc gag atc ggc acc gtg gat tat tcc ggc cgc 3283 Ser Leu Ser Glu Gly Ile Glu Ile Gly Thr Val Asp Tyr Ser Gly Arg 1050 1055 1060 agt ctc agc cac agc atc cgc gat tcc tcc aag ctt ccg ggt cag gtg 3331 Ser Leu Ser His Ser Ile Arg Asp Ser Ser Lys Leu Pro Gly Gln Val 1065 1070 1075 gaa tcc gtg gtg att ctg gtc gat gag gtt cgt tcc tca caa acc tca 3379 Glu Ser Val Val Ile Leu Val Asp Glu Val Arg Ser Ser Gln Thr Ser 1080 1085 1090 gac acc aat cca cag atg cag atc gct gaa gta caa ctt gtt ggt tgg 3427 Asp Thr Asn Pro Gln Met Gln Ile Ala Glu Val Gln Leu Val Gly Trp 1095 1100 1105 taaattacgc gtttgtgatt gacccccatt 3457 <210> 148 <211> 1109 <212> PRT <213> Corynebacterium glutamicum <400> 148 Val Ser Ser Ser Leu Ser Asn Asn Ser Glu Gln Ser Gly Leu Arg Gly 1 5 10 15 Arg Ile Val Ala Pro Ala Pro Pro Ala Pro Val Pro Glu Ala Arg Lys 20 25 30 Lys Ala Val Ala Arg Thr Asp Gly Asp Arg Ser Ser Leu Lys Asn Ser 35 40 45 Pro Thr Ala Ser Ala Thr Gln Ala Ala Gln Thr Arg Pro Ala Glu Pro 50 55 60 Glu Pro Lys Lys His Thr Ser Asp Ser Asp Val Val Arg Ser Thr Gly 65 70 75 80 Ser Met Ala Ile Ala Thr Leu Leu Ser Arg Ile Thr Gly Phe Leu Arg 85 90 95 Thr Val Met Ile Gly Ala Ala Leu Ser Pro Ala Ile Ala Ser Ala Phe 100 105 110 Asn Thr Ala Asn Thr Leu Pro Asn Leu Ile Thr Glu Ile Val Leu Gly 115 120 125 Ala Val Leu Thr Ser Leu Val Ile Pro Val Leu Thr Arg Ala Glu Lys 130 135 140 Glu Asp Ala Asp Gly Gly Ser Gly Phe Phe Arg Arg Leu Leu Thr Leu 145 150 155 160 Ser Val Thr Leu Leu Gly Gly Val Thr Ile Leu Ser Ile Ile Gly Ala 165 170 175 Pro Leu Leu Thr Arg Met Met Leu Ser Ser Glu Gly Gln Val Asn Val 180 185 190 Val Met Ser Thr Ala Phe Ala Tyr Trp Leu Leu Pro Gln Ile Phe Phe 195 200 205 Tyr Gly Leu Phe Ala Leu Phe Met Ala Val Leu Asn Thr Arg Glu Val 210 215 220 Phe Lys Pro Gly Ala Trp Ala Pro Val Val Asn Asn Val Ile Thr Leu 225 230 235 240 Thr Val Leu Gly Val Tyr Met Val Leu Pro Ala Arg Leu His Pro His 245 250 255 Glu Gln Val Gly Ile Phe Asp Pro Gln Ile Ile Phe Leu Gly Val Gly 260 265 270 Thr Thr Leu Gly Val Val Ala Gln Cys Leu Ile Met Ile Pro Tyr Leu 275 280 285 Arg Arg Ala Gly Ile Asp Met Arg Pro Leu Trp Gly Ile Asp Ala Arg 290 295 300 Leu Lys Gln Phe Gly Gly Met Ala Met Ala Ile Ile Val Tyr Val Ala 305 310 315 320 Ile Ser Gln Phe Gly Tyr Ile Ile Thr Thr Arg Ile Ala Ser Ile Ala 325 330 335 Asp Asp Ala Ala Pro Phe Ile Tyr Gln Gln His Trp Met Leu Leu Gln 340 345 350 Val Pro Tyr Gly Ile Ile Gly Val Thr Leu Leu Thr Ala Ile Met Pro 355 360 365 Arg Leu Ser Arg Asn Ala Ala Asp Gly Asp Asp Arg Ala Val Val Ser 370 375 380 Asp Leu Gln Leu Gly Ser Lys Leu Thr Phe Ile Ala Leu Ile Pro Ile 385 390 395 400 Val Val Phe Phe Thr Ala Phe Gly Val Pro Ile Ala Asn Gly Leu Phe 405 410 415 Ala Tyr Gly Gln Phe Asp Ala Asn Ala Ala Asn Ile Leu Gly Trp Thr 420 425 430 Leu Ser Phe Ser Ala Phe Thr Leu Ile Pro Tyr Ala Leu Val Leu Leu 435 440 445 His Leu Arg Val Phe Tyr Ala Arg Glu Glu Val Trp Thr Pro Thr Phe 450 455 460 Ile Ile Ala Gly Ile Thr Ala Thr Lys Val Val Leu Ser Leu Leu Ala 465 470 475 480 Pro Leu Leu Ser Ser Ser Pro Glu Arg Val Val Val Leu Leu Gly Ala 485 490 495 Ala Asn Gly Phe Ser Phe Ile Thr Gly Ala Val Ile Gly Ala Tyr Leu 500 505 510 Leu Arg Asn Lys Leu Gly Leu Leu Gly Met Arg Ser Leu Ala Lys Thr 515 520 525 Ser Leu Trp Ala Leu Gly Ser Ala Ala Val Gly Ala Ala Ala Ala Trp 530 535 540 Ala Leu Gly Trp Leu Ile Gln Ala Val Val Gly Asp Phe Leu Leu Gly 545 550 555 560 Thr Leu Ser Ser Val Gly Tyr Leu Leu Asn Leu Ala Val Leu Gly Val 565 570 575 Phe Phe Ile Phe Val Thr Gly Ile Val Leu Ser Arg Ser Gly Leu Pro 580 585 590 Glu Val Gln Asn Leu Gly Gln Ala Leu Thr Arg Ile Pro Gly Leu Ser 595 600 605 Arg Phe Ile Arg Pro Asn Thr Lys Ile Ser Leu Asp Val Gly Glu Val 610 615 620 Ser Glu Gln Asp Phe Ser Thr Gln Leu Val Ala Pro Ser Glu Phe Ala 625 630 635 640 Ala Thr Pro Val Pro Pro Pro Met Ser Ala Gly Ile Val Arg Gly Pro 645 650 655 Arg Leu Val Pro Gly Ala Pro Val Gly Asp Gly Arg Phe Arg Leu Leu 660 665 670 Ala Asp His Gly Gly Val Gln Gly Ala Arg Phe Trp Gln Ala Arg Glu 675 680 685 Ile Ala Thr Gly Lys Glu Val Ala Leu Ile Phe Val Asp Thr Ser Gly 690 695 700 Asn Ala Pro Phe Ala Pro Leu Ser Ser Ala Ala Ala Ala Gly Ile Ala 705 710 715 720 Tyr Glu Val Gln Arg Arg Thr Lys Lys Leu Ala Ser Leu Gly Ser Leu 725 730 735 Ala Val Ala Pro Asn Ile His Ser Glu Ala Tyr Arg Asn Gly Cys Leu 740 745 750 Ile Val Ala Asp Trp Val Pro Gly Ser Ser Leu Ser Ala Val Ala Glu 755 760 765 Ser Gly Ala Asp Pro Arg Ala Ala Ala Phe Ala Leu Ala Glu Leu Thr 770 775 780 Glu Thr Ile Gly Glu Ala His Glu Met Gly Ile Pro Ala Gly Leu Asp 785 790 795 800 Asn Lys Cys Arg Ile Arg Ile Asn Thr Asp Gly His Ala Val Leu Ala 805 810 815 Phe Pro Ala Ile Leu Pro Asp Ala Ser Glu Leu Arg Asp Ala Lys Ser 820 825 830 Leu Ala Ser Ala Ala Glu Met Leu Ile Asp Ala Thr Leu Ala Pro Ser 835 840 845 Asp Val Lys Ala Met Val Thr Glu Ala Gln Gly Leu Ala Thr Glu Asp 850 855 860 Asn Pro Asp Tyr Ala Ser Leu Ala Met Ala Met Arg Thr Cys Gly Leu 865 870 875 880 Phe Thr Glu Glu Pro Thr His Leu Val Val Lys Lys Glu Lys Thr Pro 885 890 895 Lys Pro Ala Thr Arg Asp Gly Phe Gly Ala Ser Asp Tyr Thr Val Lys 900 905 910 Gly Met Ala Ala Ile Ala Ala Val Val Ile Ile Leu Val Ser Leu Val 915 920 925 Ala Ala Gly Thr Ala Phe Leu Thr Ser Phe Phe Gly Ser Ser Thr Asn 930 935 940 Glu Gln Ser Pro Leu Ala Ser Val Glu Ala Thr Thr Ser Ala Thr Pro 945 950 955 960 Glu Pro Val Gly Pro Pro Val Tyr Leu Asp Leu Asp Gln Ala Arg Thr 965 970 975 Trp Asp Asp Gly Ala Gly Thr Asp Val Thr Asp Val Thr Asp Gly Asn 980 985 990 Thr Ser Thr Ala Trp Thr Ser Thr Gly Gly Asp Gly Leu Leu Val Asp 995 1000 1005 Leu Ser Thr Pro Ala Arg Leu Asp Arg Val Ile Leu Thr Thr Gly Thr 1010 1015 1020 Gly Ser Asp Ser Asn Val Thr Ser Thr Val Lys Ile Tyr Ala Phe Asn 1025 1030 1035 1040 Asp Ala Ser Pro His Ser Leu Ser Glu Gly Ile Glu Ile Gly Thr Val 1045 1050 1055 Asp Tyr Ser Gly Arg Ser Leu Ser His Ser Ile Arg Asp Ser Ser Lys 1060 1065 1070 Leu Pro Gly Gln Val Glu Ser Val Val Ile Leu Val Asp Glu Val Arg 1075 1080 1085 Ser Ser Gln Thr Ser Asp Thr Asn Pro Gln Met Gln Ile Ala Glu Val 1090 1095 1100 Gln Leu Val Gly Trp 1105 <210> 149 <211> 676 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(646) <223> RXA01439 <400> 149 gttaatccac agcgccctgt gtgcactcta ttagtgaata tccggtgaat gctcgtccct 60 cgactgtcta cttagtaggt ttgcaggcta gtcttttgtc atg acc cga tac ttt 115 Met Thr Arg Tyr Phe 1 5 gca gtt tcc aat ctt cag gag ctt ggc tcc ctc gaa gta cac aaa ttg 163 Ala Val Ser Asn Leu Gln Glu Leu Gly Ser Leu Glu Val His Lys Leu 10 15 20 tac aaa ctt cgt gta gat att ttc gtc cac gag cag cag act ccg tac 211 Tyr Lys Leu Arg Val Asp Ile Phe Val His Glu Gln Gln Thr Pro Tyr 25 30 35 gcg gag atc gat gac acc gat gct gcc cca acc acc aat cac atc ctg 259 Ala Glu Ile Asp Asp Thr Asp Ala Ala Pro Thr Thr Asn His Ile Leu 40 45 50 gtt tgg gag cgc gcc gac gcc acc cca acc aac ctc atc ggc tgc gca 307 Val Trp Glu Arg Ala Asp Ala Thr Pro Thr Asn Leu Ile Gly Cys Ala 55 60 65 cgc ctc gcg ccc atc acc gcc gcc gag ctt aag gcg tac acc ggc aag 355 Arg Leu Ala Pro Ile Thr Ala Ala Glu Leu Lys Ala Tyr Thr Gly Lys 70 75 80 85 ggc att tcg ctt gac gac gcc acc ccg ctc tca caa ctc ggc cgc gta 403 Gly Ile Ser Leu Asp Asp Ala Thr Pro Leu Ser Gln Leu Gly Arg Val 90 95 100 gcg gtg gca cag gaa ggg cgg ggc tcg ggg ctc tca ggt gag ctc atg 451 Ala Val Ala Gln Glu Gly Arg Gly Ser Gly Leu Ser Gly Glu Leu Met 105 110 115 cgc aac gcg ctg cgt ctt gca tat gag cag tac ccc gac cgc gat gtt 499 Arg Asn Ala Leu Arg Leu Ala Tyr Glu Gln Tyr Pro Asp Arg Asp Val 120 125 130 gtc ctg acc gcg cag aag cct ttg gta gat ttc tac gca gaa tac ggc 547 Val Leu Thr Ala Gln Lys Pro Leu Val Asp Phe Tyr Ala Glu Tyr Gly 135 140 145 ttt gag gtc ttg ggt gag gaa tac ctt gac tcg ggt gtt cct cac ctt 595 Phe Glu Val Leu Gly Glu Glu Tyr Leu Asp Ser Gly Val Pro His Leu 150 155 160 165 ccg atg ttg ctc aag gct gat gag ctt gaa agg ttc tca gac cta gac 643 Pro Met Leu Leu Lys Ala Asp Glu Leu Glu Arg Phe Ser Asp Leu Asp 170 175 180 gcc taatccgtag tcactggaac tcacccacat 676 Ala <210> 150 <211> 182 <212> PRT <213> Corynebacterium glutamicum <400> 150 Met Thr Arg Tyr Phe Ala Val Ser Asn Leu Gln Glu Leu Gly Ser Leu 1 5 10 15 Glu Val His Lys Leu Tyr Lys Leu Arg Val Asp Ile Phe Val His Glu 20 25 30 Gln Gln Thr Pro Tyr Ala Glu Ile Asp Asp Thr Asp Ala Ala Pro Thr 35 40 45 Thr Asn His Ile Leu Val Trp Glu Arg Ala Asp Ala Thr Pro Thr Asn 50 55 60 Leu Ile Gly Cys Ala Arg Leu Ala Pro Ile Thr Ala Ala Glu Leu Lys 65 70 75 80 Ala Tyr Thr Gly Lys Gly Ile Ser Leu Asp Asp Ala Thr Pro Leu Ser 85 90 95 Gln Leu Gly Arg Val Ala Val Ala Gln Glu Gly Arg Gly Ser Gly Leu 100 105 110 Ser Gly Glu Leu Met Arg Asn Ala Leu Arg Leu Ala Tyr Glu Gln Tyr 115 120 125 Pro Asp Arg Asp Val Val Leu Thr Ala Gln Lys Pro Leu Val Asp Phe 130 135 140 Tyr Ala Glu Tyr Gly Phe Glu Val Leu Gly Glu Glu Tyr Leu Asp Ser 145 150 155 160 Gly Val Pro His Leu Pro Met Leu Leu Lys Ala Asp Glu Leu Glu Arg 165 170 175 Phe Ser Asp Leu Asp Ala 180 <210> 151 <211> 1159 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1129) <223> RXA01441 <400> 151 ttataacaat tagccgtgag ggtattaatc aaggtttcgg gagactaacg ttttagaaac 60 aagtggactc cagcacacct cgtgagatgg caggttcatc atg gct aga acg aca 115 Met Ala Arg Thr Thr 1 5 aca gcg cac gca gtt ctc atg gcg ctt agt tca gtc ggg ctt ttg atg 163 Thr Ala His Ala Val Leu Met Ala Leu Ser Ser Val Gly Leu Leu Met 10 15 20 ctc cag gcc tgc tcc gaa cag gaa caa acc cca gaa caa acg cca gcg 211 Leu Gln Ala Cys Ser Glu Gln Glu Gln Thr Pro Glu Gln Thr Pro Ala 25 30 35 ccc acc ctg act tcg cag gct ccc gag act cct caa gcc tca aca acc 259 Pro Thr Leu Thr Ser Gln Ala Pro Glu Thr Pro Gln Ala Ser Thr Thr 40 45 50 tcc tca gca agc tcc aca gca act ccc ata gca act ccc ata gca gcc 307 Ser Ser Ala Ser Ser Thr Ala Thr Pro Ile Ala Thr Pro Ile Ala Ala 55 60 65 acc gag ttg gat tat ctc cac atc gat cca gca acg tat gac atc ggt 355 Thr Glu Leu Asp Tyr Leu His Ile Asp Pro Ala Thr Tyr Asp Ile Gly 70 75 80 85 gtc caa gac caa gaa act gcc gta ttt acc act ggc gat ggg atc aca 403 Val Gln Asp Gln Glu Thr Ala Val Phe Thr Thr Gly Asp Gly Ile Thr 90 95 100 gcg cag tgt ttc ttc gag gca aca ccg ggg gag acc agc tat cag atc 451 Ala Gln Cys Phe Phe Glu Ala Thr Pro Gly Glu Thr Ser Tyr Gln Ile 105 110 115 aag gag ttt gat ttc gac gaa act gcg gga acg tgc gct ttt ggt gat 499 Lys Glu Phe Asp Phe Asp Glu Thr Ala Gly Thr Cys Ala Phe Gly Asp 120 125 130 caa cac atc agc gtc acc acg gat gaa aat gtc cgg gaa cgc ttt gcc 547 Gln His Ile Ser Val Thr Thr Asp Glu Asn Val Arg Glu Arg Phe Ala 135 140 145 gaa ttg agt gaa acc gaa gaa gaa tta cca gaa gcg caa gcg act ctc 595 Glu Leu Ser Glu Thr Glu Glu Glu Leu Pro Glu Ala Gln Ala Thr Leu 150 155 160 165 gat gtt ggt gag atg gtg cat ctt ggt cac atg ggt tgt tgg gcg ccg 643 Asp Val Gly Glu Met Val His Leu Gly His Met Gly Cys Trp Ala Pro 170 175 180 agt gta tcg gag ttt agt tgt ctc gat ttc gcc tcc aac cag gcg ttc 691 Ser Val Ser Glu Phe Ser Cys Leu Asp Phe Ala Ser Asn Gln Ala Phe 185 190 195 acc atg aat gaa cag ggc ttc cat gag ctt gat cct gca aaa gcc act 739 Thr Met Asn Glu Gln Gly Phe His Glu Leu Asp Pro Ala Lys Ala Thr 200 205 210 gag cag cta att aat tcg agt ggc cag gtt caa acg tta tcg aaa atg 787 Glu Gln Leu Ile Asn Ser Ser Gly Gln Val Gln Thr Leu Ser Lys Met 215 220 225 acg aat ttc cag ttc acc gat ggc acc agc atc acc tgt gtc agt gag 835 Thr Asn Phe Gln Phe Thr Asp Gly Thr Ser Ile Thr Cys Val Ser Glu 230 235 240 245 ttg cag gcg gaa gag ttc ttg tgc cac aac agt ggt cct gga ggc tgg 883 Leu Gln Ala Glu Glu Phe Leu Cys His Asn Ser Gly Pro Gly Gly Trp 250 255 260 tca act tca gct ggc cct gcc aac acc ctg tgg tgg aat ctg aac cag 931 Ser Thr Ser Ala Gly Pro Ala Asn Thr Leu Trp Trp Asn Leu Asn Gln 265 270 275 gcc gac tcc gag ttt gag ggt gct cgc ccc acg aat cca acg caa agc 979 Ala Asp Ser Glu Phe Glu Gly Ala Arg Pro Thr Asn Pro Thr Gln Ser 280 285 290 gtt tat aaa tct caa caa ata ttc ggt ccg gga tcg tat ctc ctc gcg 1027 Val Tyr Lys Ser Gln Gln Ile Phe Gly Pro Gly Ser Tyr Leu Leu Ala 295 300 305 aac ggt gtg agt gca gaa ttt gat gga acc acc ctc acg ctg acc acg 1075 Asn Gly Val Ser Ala Glu Phe Asp Gly Thr Thr Leu Thr Leu Thr Thr 310 315 320 325 cct cag ggg aat cag tat tgg gca aac aca cac gat ttt gga gcc ggc 1123 Pro Gln Gly Asn Gln Tyr Trp Ala Asn Thr His Asp Phe Gly Ala Gly 330 335 340 aca cac taattttagg agcactgatg aaaaccaagt 1159 Thr His <210> 152 <211> 343 <212> PRT <213> Corynebacterium glutamicum <400> 152 Met Ala Arg Thr Thr Thr Ala His Ala Val Leu Met Ala Leu Ser Ser 1 5 10 15 Val Gly Leu Leu Met Leu Gln Ala Cys Ser Glu Gln Glu Gln Thr Pro 20 25 30 Glu Gln Thr Pro Ala Pro Thr Leu Thr Ser Gln Ala Pro Glu Thr Pro 35 40 45 Gln Ala Ser Thr Thr Ser Ser Ala Ser Ser Thr Ala Thr Pro Ile Ala 50 55 60 Thr Pro Ile Ala Ala Thr Glu Leu Asp Tyr Leu His Ile Asp Pro Ala 65 70 75 80 Thr Tyr Asp Ile Gly Val Gln Asp Gln Glu Thr Ala Val Phe Thr Thr 85 90 95 Gly Asp Gly Ile Thr Ala Gln Cys Phe Phe Glu Ala Thr Pro Gly Glu 100 105 110 Thr Ser Tyr Gln Ile Lys Glu Phe Asp Phe Asp Glu Thr Ala Gly Thr 115 120 125 Cys Ala Phe Gly Asp Gln His Ile Ser Val Thr Thr Asp Glu Asn Val 130 135 140 Arg Glu Arg Phe Ala Glu Leu Ser Glu Thr Glu Glu Glu Leu Pro Glu 145 150 155 160 Ala Gln Ala Thr Leu Asp Val Gly Glu Met Val His Leu Gly His Met 165 170 175 Gly Cys Trp Ala Pro Ser Val Ser Glu Phe Ser Cys Leu Asp Phe Ala 180 185 190 Ser Asn Gln Ala Phe Thr Met Asn Glu Gln Gly Phe His Glu Leu Asp 195 200 205 Pro Ala Lys Ala Thr Glu Gln Leu Ile Asn Ser Ser Gly Gln Val Gln 210 215 220 Thr Leu Ser Lys Met Thr Asn Phe Gln Phe Thr Asp Gly Thr Ser Ile 225 230 235 240 Thr Cys Val Ser Glu Leu Gln Ala Glu Glu Phe Leu Cys His Asn Ser 245 250 255 Gly Pro Gly Gly Trp Ser Thr Ser Ala Gly Pro Ala Asn Thr Leu Trp 260 265 270 Trp Asn Leu Asn Gln Ala Asp Ser Glu Phe Glu Gly Ala Arg Pro Thr 275 280 285 Asn Pro Thr Gln Ser Val Tyr Lys Ser Gln Gln Ile Phe Gly Pro Gly 290 295 300 Ser Tyr Leu Leu Ala Asn Gly Val Ser Ala Glu Phe Asp Gly Thr Thr 305 310 315 320 Leu Thr Leu Thr Thr Pro Gln Gly Asn Gln Tyr Trp Ala Asn Thr His 325 330 335 Asp Phe Gly Ala Gly Thr His 340 <210> 153 <211> 1297 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1267) <223> RXA01448 <400> 153 gtaatctcag cagttaaaaa gggcagttcc gcatcagggg gactgccctt tttcgtgtct 60 tctcatgctc ttgtgaatat gcatagctaa tcttgaggcc atg gca aag aag aaa 115 Met Ala Lys Lys Lys 1 5 ctg ggg act gtc gcc aga ctg tct gaa ctg gat aag tcc ctg cgc aat 163 Leu Gly Thr Val Ala Arg Leu Ser Glu Leu Asp Lys Ser Leu Arg Asn 10 15 20 aga ttg ctg cgg gtt cgt tcc cga ctg ctg ttt att gtt cat tcc gca 211 Arg Leu Leu Arg Val Arg Ser Arg Leu Leu Phe Ile Val His Ser Ala 25 30 35 att ggt gcg ggt gtg gcg tat tgg atc gcc gtg gaa gtg atc aaa cac 259 Ile Gly Ala Gly Val Ala Tyr Trp Ile Ala Val Glu Val Ile Lys His 40 45 50 gga caa ccg ttt ttc gca ccg atg tcc gcg gtg att att ttg ggt ctc 307 Gly Gln Pro Phe Phe Ala Pro Met Ser Ala Val Ile Ile Leu Gly Leu 55 60 65 tcc gga gga gac cgc atc aaa aga gcc acg gaa ctc acc ctg ggc tgt 355 Ser Gly Gly Asp Arg Ile Lys Arg Ala Thr Glu Leu Thr Leu Gly Cys 70 75 80 85 gct tta ggc gtt ggt ttg ggt gat tta ctg atc atg caa atc ggc acg 403 Ala Leu Gly Val Gly Leu Gly Asp Leu Leu Ile Met Gln Ile Gly Thr 90 95 100 ggc tat tgg cag ata ttt gtg gta gtt gga tta gcg ctg ctg gtg gcc 451 Gly Tyr Trp Gln Ile Phe Val Val Val Gly Leu Ala Leu Leu Val Ala 105 110 115 tcg ttt gtt tca ccg gca ccg ttg gtg agt aat cag atg gcc att ggt 499 Ser Phe Val Ser Pro Ala Pro Leu Val Ser Asn Gln Met Ala Ile Gly 120 125 130 ggc att ttg att gcc acg atg ttc ccg cca ggt gat ggt gga agc att 547 Gly Ile Leu Ile Ala Thr Met Phe Pro Pro Gly Asp Gly Gly Ser Ile 135 140 145 gac cgt atg atc gac gcc ttc att ggt ggt ggc gtg gga att ttg gtc 595 Asp Arg Met Ile Asp Ala Phe Ile Gly Gly Gly Val Gly Ile Leu Val 150 155 160 165 atc gca ctt ctt ccc tca tct cct ctt gac gca ggc cgg cat caa gtg 643 Ile Ala Leu Leu Pro Ser Ser Pro Leu Asp Ala Gly Arg His Gln Val 170 175 180 gcc aac gtt ttg ggg atc gca gct agt gtg ctg gaa gac gtg gca gct 691 Ala Asn Val Leu Gly Ile Ala Ala Ser Val Leu Glu Asp Val Ala Ala 185 190 195 tcc cta aaa gcc aag gat gca gcc aaa ctc aac aat gct ttg gaa gca 739 Ser Leu Lys Ala Lys Asp Ala Ala Lys Leu Asn Asn Ala Leu Glu Ala 200 205 210 ttg aga agg tcg cag gcg tcg gtg aac aag ctg gaa act gcg gca tct 787 Leu Arg Arg Ser Gln Ala Ser Val Asn Lys Leu Glu Thr Ala Ala Ser 215 220 225 tca ggc aag gaa gca acc acc gta tcg cca ttt tta tgg gga gat agg 835 Ser Gly Lys Glu Ala Thr Thr Val Ser Pro Phe Leu Trp Gly Asp Arg 230 235 240 245 gcc cgc gtg aga tcg ctg tat cgc att ctg gcg cca gtg gac aac gtc 883 Ala Arg Val Arg Ser Leu Tyr Arg Ile Leu Ala Pro Val Asp Asn Val 250 255 260 atc cga aat gct cga gtc ctt gcg cga cgg gca gtg gtg ctg acc gaa 931 Ile Arg Asn Ala Arg Val Leu Ala Arg Arg Ala Val Val Leu Thr Glu 265 270 275 gac aat gac acc gtc agt gat gaa caa atc cac gtg att gag gaa atc 979 Asp Asn Asp Thr Val Ser Asp Glu Gln Ile His Val Ile Glu Glu Ile 280 285 290 gca gac att gca ctg cga ctg tca gac ctt tat gag cac cac aaa gaa 1027 Ala Asp Ile Ala Leu Arg Leu Ser Asp Leu Tyr Glu His His Lys Glu 295 300 305 atc agt gaa gca ctg gaa att cct gag ttg gtt aac cga ctg cgt caa 1075 Ile Ser Glu Ala Leu Glu Ile Pro Glu Leu Val Asn Arg Leu Arg Gln 310 315 320 325 ctg ggc agt gaa gtg ggc gag gac atc gcc gaa gat cga gtg cta tcc 1123 Leu Gly Ser Glu Val Gly Glu Asp Ile Ala Glu Asp Arg Val Leu Ser 330 335 340 gca caa gta att ttg gcg caa tcg cga tcc atc att gtg gac ctg ttg 1171 Ala Gln Val Ile Leu Ala Gln Ser Arg Ser Ile Ile Val Asp Leu Leu 345 350 355 cag atc tgc ggc atg tcc agg gaa tct gcg gtg gca gtg ttg gtt ccg 1219 Gln Ile Cys Gly Met Ser Arg Glu Ser Ala Val Ala Val Leu Val Pro 360 365 370 acc tca gag agt ccg gct tac cct ccg gag ctg tgg gat gac gaa gac 1267 Thr Ser Glu Ser Pro Ala Tyr Pro Pro Glu Leu Trp Asp Asp Glu Asp 375 380 385 tagcctttta tcgcggttcg gttttcacgg 1297 <210> 154 <211> 389 <212> PRT <213> Corynebacterium glutamicum <400> 154 Met Ala Lys Lys Lys Leu Gly Thr Val Ala Arg Leu Ser Glu Leu Asp 1 5 10 15 Lys Ser Leu Arg Asn Arg Leu Leu Arg Val Arg Ser Arg Leu Leu Phe 20 25 30 Ile Val His Ser Ala Ile Gly Ala Gly Val Ala Tyr Trp Ile Ala Val 35 40 45 Glu Val Ile Lys His Gly Gln Pro Phe Phe Ala Pro Met Ser Ala Val 50 55 60 Ile Ile Leu Gly Leu Ser Gly Gly Asp Arg Ile Lys Arg Ala Thr Glu 65 70 75 80 Leu Thr Leu Gly Cys Ala Leu Gly Val Gly Leu Gly Asp Leu Leu Ile 85 90 95 Met Gln Ile Gly Thr Gly Tyr Trp Gln Ile Phe Val Val Val Gly Leu 100 105 110 Ala Leu Leu Val Ala Ser Phe Val Ser Pro Ala Pro Leu Val Ser Asn 115 120 125 Gln Met Ala Ile Gly Gly Ile Leu Ile Ala Thr Met Phe Pro Pro Gly 130 135 140 Asp Gly Gly Ser Ile Asp Arg Met Ile Asp Ala Phe Ile Gly Gly Gly 145 150 155 160 Val Gly Ile Leu Val Ile Ala Leu Leu Pro Ser Ser Pro Leu Asp Ala 165 170 175 Gly Arg His Gln Val Ala Asn Val Leu Gly Ile Ala Ala Ser Val Leu 180 185 190 Glu Asp Val Ala Ala Ser Leu Lys Ala Lys Asp Ala Ala Lys Leu Asn 195 200 205 Asn Ala Leu Glu Ala Leu Arg Arg Ser Gln Ala Ser Val Asn Lys Leu 210 215 220 Glu Thr Ala Ala Ser Ser Gly Lys Glu Ala Thr Thr Val Ser Pro Phe 225 230 235 240 Leu Trp Gly Asp Arg Ala Arg Val Arg Ser Leu Tyr Arg Ile Leu Ala 245 250 255 Pro Val Asp Asn Val Ile Arg Asn Ala Arg Val Leu Ala Arg Arg Ala 260 265 270 Val Val Leu Thr Glu Asp Asn Asp Thr Val Ser Asp Glu Gln Ile His 275 280 285 Val Ile Glu Glu Ile Ala Asp Ile Ala Leu Arg Leu Ser Asp Leu Tyr 290 295 300 Glu His His Lys Glu Ile Ser Glu Ala Leu Glu Ile Pro Glu Leu Val 305 310 315 320 Asn Arg Leu Arg Gln Leu Gly Ser Glu Val Gly Glu Asp Ile Ala Glu 325 330 335 Asp Arg Val Leu Ser Ala Gln Val Ile Leu Ala Gln Ser Arg Ser Ile 340 345 350 Ile Val Asp Leu Leu Gln Ile Cys Gly Met Ser Arg Glu Ser Ala Val 355 360 365 Ala Val Leu Val Pro Thr Ser Glu Ser Pro Ala Tyr Pro Pro Glu Leu 370 375 380 Trp Asp Asp Glu Asp 385 <210> 155 <211> 604 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(574) <223> RXA01518 <400> 155 agcagaacct gatgccgtcc tgcacggcac gaccattgca gaacatgtgg ataatcttga 60 tcccacagac attgaaggtg tcaccaagat ttaaggagtc gtg gct ttc atg cag 115 Val Ala Phe Met Gln 1 5 aaa acg tca gcg ggt tgg ttg atc gca acg gga ggt ttc ctc gcc gct 163 Lys Thr Ser Ala Gly Trp Leu Ile Ala Thr Gly Gly Phe Leu Ala Ala 10 15 20 gtg tcc gcc att ttg acg tgg cgt ttt tat gga tcc atg acc tct att 211 Val Ser Ala Ile Leu Thr Trp Arg Phe Tyr Gly Ser Met Thr Ser Ile 25 30 35 tcc atc acg gta tcc atc act ttt tgg ttg ttg gcc gtg gtg tgt ggt 259 Ser Ile Thr Val Ser Ile Thr Phe Trp Leu Leu Ala Val Val Cys Gly 40 45 50 ttc gca ggt gtg aag gtc caa ggt cgc ctc gat gag ggg ctg atc ggc 307 Phe Ala Gly Val Lys Val Gln Gly Arg Leu Asp Glu Gly Leu Ile Gly 55 60 65 cag gac aaa tcc caa atg aac ccc gtg acc att gcc tat ctg gcc atg 355 Gln Asp Lys Ser Gln Met Asn Pro Val Thr Ile Ala Tyr Leu Ala Met 70 75 80 85 ctg ggt cga gcg tgt gcg tgg ggt ggc gca att ttc ggc ggc gtt tat 403 Leu Gly Arg Ala Cys Ala Trp Gly Gly Ala Ile Phe Gly Gly Val Tyr 90 95 100 gtg gga att ggc agt tat gta atc cca cgc gcc ggt gag ttg tcc gca 451 Val Gly Ile Gly Ser Tyr Val Ile Pro Arg Ala Gly Glu Leu Ser Ala 105 110 115 gca tcg aat gat ctt ccg gga gtt att gcc tgt gcg ctg ggc gga atc 499 Ala Ser Asn Asp Leu Pro Gly Val Ile Ala Cys Ala Leu Gly Gly Ile 120 125 130 gca ctc tca gct gcc gga ctt tat tta gag cga agc tgt gag gct ccg 547 Ala Leu Ser Ala Ala Gly Leu Tyr Leu Glu Arg Ser Cys Glu Ala Pro 135 140 145 cct ccc caa tct ggc gaa gcg atc agc tagattggaa ttcatgaatc 594 Pro Pro Gln Ser Gly Glu Ala Ile Ser 150 155 aagacctgtc 604 <210> 156 <211> 158 <212> PRT <213> Corynebacterium glutamicum <400> 156 Val Ala Phe Met Gln Lys Thr Ser Ala Gly Trp Leu Ile Ala Thr Gly 1 5 10 15 Gly Phe Leu Ala Ala Val Ser Ala Ile Leu Thr Trp Arg Phe Tyr Gly 20 25 30 Ser Met Thr Ser Ile Ser Ile Thr Val Ser Ile Thr Phe Trp Leu Leu 35 40 45 Ala Val Val Cys Gly Phe Ala Gly Val Lys Val Gln Gly Arg Leu Asp 50 55 60 Glu Gly Leu Ile Gly Gln Asp Lys Ser Gln Met Asn Pro Val Thr Ile 65 70 75 80 Ala Tyr Leu Ala Met Leu Gly Arg Ala Cys Ala Trp Gly Gly Ala Ile 85 90 95 Phe Gly Gly Val Tyr Val Gly Ile Gly Ser Tyr Val Ile Pro Arg Ala 100 105 110 Gly Glu Leu Ser Ala Ala Ser Asn Asp Leu Pro Gly Val Ile Ala Cys 115 120 125 Ala Leu Gly Gly Ile Ala Leu Ser Ala Ala Gly Leu Tyr Leu Glu Arg 130 135 140 Ser Cys Glu Ala Pro Pro Pro Gln Ser Gly Glu Ala Ile Ser 145 150 155 <210> 157 <211> 1372 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1342) <223> RXA01536 <400> 157 agcatagatg acttgacact gttgcagcag gcggttttca cctggcctct taggatttgg 60 tcaaatggtt gcaacgacgc cagggaagga ggcgcacccc atg gca ttt gga ttt 115 Met Ala Phe Gly Phe 1 5 ttt agt aga cgt aag aaa aag aac aaa gac aaa aac ccg aat gaa aat 163 Phe Ser Arg Arg Lys Lys Lys Asn Lys Asp Lys Asn Pro Asn Glu Asn 10 15 20 tca gca gtg ccc gca cac tct gaa gat tca cct cag gag gtt ttt gag 211 Ser Ala Val Pro Ala His Ser Glu Asp Ser Pro Gln Glu Val Phe Glu 25 30 35 ggt aat ggt cgt cag gta ggc gac ccc att gaa cag cag gtt gat cga 259 Gly Asn Gly Arg Gln Val Gly Asp Pro Ile Glu Gln Gln Val Asp Arg 40 45 50 gat gct aaa ggt cgt ctc aca gcg gcg gat ttc ttg ccg gac gct gat 307 Asp Ala Lys Gly Arg Leu Thr Ala Ala Asp Phe Leu Pro Asp Ala Asp 55 60 65 ctg cca cag ctg aat cgt tcg cgt gca aat atg ctg cgc cgt gaa ttg 355 Leu Pro Gln Leu Asn Arg Ser Arg Ala Asn Met Leu Arg Arg Glu Leu 70 75 80 85 gag tac cgt ttt tca ctc cag aat gcc cac att aat atc gat gga aac 403 Glu Tyr Arg Phe Ser Leu Gln Asn Ala His Ile Asn Ile Asp Gly Asn 90 95 100 acg gcc atg att cag cgt tca gat ggc ggg gca gca cat gtc tcg ttg 451 Thr Ala Met Ile Gln Arg Ser Asp Gly Gly Ala Ala His Val Ser Leu 105 110 115 cgc acc ctc gcg atg aat gca gct ggc ctt gat aac ttt gat caa ctc 499 Arg Thr Leu Ala Met Asn Ala Ala Gly Leu Asp Asn Phe Asp Gln Leu 120 125 130 cct gaa ctg gtg gaa agc ttc gtt cac ggc acg ctg gcc gat gca aca 547 Pro Glu Leu Val Glu Ser Phe Val His Gly Thr Leu Ala Asp Ala Thr 135 140 145 tta aac gat ctt tct act gct gac ctg tat aaa gca ctg cgc ctt cgc 595 Leu Asn Asp Leu Ser Thr Ala Asp Leu Tyr Lys Ala Leu Arg Leu Arg 150 155 160 165 ctg ctg cca aca cct ggc gaa ggc gac gat cta gtt gag cat gga ctc 643 Leu Leu Pro Thr Pro Gly Glu Gly Asp Asp Leu Val Glu His Gly Leu 170 175 180 gac cgg gaa agc cag atc cgc gac gat tca atc ctg cgc acc ttc acc 691 Asp Arg Glu Ser Gln Ile Arg Asp Asp Ser Ile Leu Arg Thr Phe Thr 185 190 195 tct gac atg tcg atc gcg ctg gtg ctc gat acc gag cat gcc atc cgc 739 Ser Asp Met Ser Ile Ala Leu Val Leu Asp Thr Glu His Ala Ile Arg 200 205 210 atc cag cca ctc aaa gag ctc gag gag ttc gat gac ctc agc gcc cta 787 Ile Gln Pro Leu Lys Glu Leu Glu Glu Phe Asp Asp Leu Ser Ala Leu 215 220 225 gag cgg gct gcg gac cgc aat acc tgg caa gag ctt tac gac gca aac 835 Glu Arg Ala Ala Asp Arg Asn Thr Trp Gln Glu Leu Tyr Asp Ala Asn 230 235 240 245 gtt gac gct tcc ttc gtc gac gct gaa tca gac agc gaa ggg tca tca 883 Val Asp Ala Ser Phe Val Asp Ala Glu Ser Asp Ser Glu Gly Ser Ser 250 255 260 ttt tgg gct ttc gaa tct aac tcg tac tac ttg ggt agt gca cca ctg 931 Phe Trp Ala Phe Glu Ser Asn Ser Tyr Tyr Leu Gly Ser Ala Pro Leu 265 270 275 ttc ctc aac gat ctg ttg gca aag tgg gca cct gac ctg gac caa agt 979 Phe Leu Asn Asp Leu Leu Ala Lys Trp Ala Pro Asp Leu Asp Gln Ser 280 285 290 gat ggc gtc atc ttt gct gtc cct gat cgt gat ctg ttg att gcg cgt 1027 Asp Gly Val Ile Phe Ala Val Pro Asp Arg Asp Leu Leu Ile Ala Arg 295 300 305 cct gtg acc acc ggc gaa gat ctg atg aac gga atc acc gcg atg gtg 1075 Pro Val Thr Thr Gly Glu Asp Leu Met Asn Gly Ile Thr Ala Met Val 310 315 320 325 agg atc gcg atg cgc ttt ggc ctc ggg aac ccg acg tcg ata agc ccg 1123 Arg Ile Ala Met Arg Phe Gly Leu Gly Asn Pro Thr Ser Ile Ser Pro 330 335 340 cgc ctg cac ctg ctg cgc gac aac cag gtg acc acc ttc acc gac ttc 1171 Arg Leu His Leu Leu Arg Asp Asn Gln Val Thr Thr Phe Thr Asp Phe 345 350 355 cgc gtc gtc tct cct gaa atg gaa gct gaa tgg gaa gac agc gcg ttt 1219 Arg Val Val Ser Pro Glu Met Glu Ala Glu Trp Glu Asp Ser Ala Phe 360 365 370 gac gcg cca ccg gcc ggc gcg atc ggc att gag gtg cgc cca gat ccg 1267 Asp Ala Pro Pro Ala Gly Ala Ile Gly Ile Glu Val Arg Pro Asp Pro 375 380 385 tat ctg atg gag cgc ctc caa cag ggc ggc ttt ggt gat ttc gga gat 1315 Tyr Leu Met Glu Arg Leu Gln Gln Gly Gly Phe Gly Asp Phe Gly Asp 390 395 400 405 ttc ggc aag ccc cgc gat cta gat atg tagcgaaaaa gggaccttca 1362 Phe Gly Lys Pro Arg Asp Leu Asp Met 410 cttcttaaga 1372 <210> 158 <211> 414 <212> PRT <213> Corynebacterium glutamicum <400> 158 Met Ala Phe Gly Phe Phe Ser Arg Arg Lys Lys Lys Asn Lys Asp Lys 1 5 10 15 Asn Pro Asn Glu Asn Ser Ala Val Pro Ala His Ser Glu Asp Ser Pro 20 25 30 Gln Glu Val Phe Glu Gly Asn Gly Arg Gln Val Gly Asp Pro Ile Glu 35 40 45 Gln Gln Val Asp Arg Asp Ala Lys Gly Arg Leu Thr Ala Ala Asp Phe 50 55 60 Leu Pro Asp Ala Asp Leu Pro Gln Leu Asn Arg Ser Arg Ala Asn Met 65 70 75 80 Leu Arg Arg Glu Leu Glu Tyr Arg Phe Ser Leu Gln Asn Ala His Ile 85 90 95 Asn Ile Asp Gly Asn Thr Ala Met Ile Gln Arg Ser Asp Gly Gly Ala 100 105 110 Ala His Val Ser Leu Arg Thr Leu Ala Met Asn Ala Ala Gly Leu Asp 115 120 125 Asn Phe Asp Gln Leu Pro Glu Leu Val Glu Ser Phe Val His Gly Thr 130 135 140 Leu Ala Asp Ala Thr Leu Asn Asp Leu Ser Thr Ala Asp Leu Tyr Lys 145 150 155 160 Ala Leu Arg Leu Arg Leu Leu Pro Thr Pro Gly Glu Gly Asp Asp Leu 165 170 175 Val Glu His Gly Leu Asp Arg Glu Ser Gln Ile Arg Asp Asp Ser Ile 180 185 190 Leu Arg Thr Phe Thr Ser Asp Met Ser Ile Ala Leu Val Leu Asp Thr 195 200 205 Glu His Ala Ile Arg Ile Gln Pro Leu Lys Glu Leu Glu Glu Phe Asp 210 215 220 Asp Leu Ser Ala Leu Glu Arg Ala Ala Asp Arg Asn Thr Trp Gln Glu 225 230 235 240 Leu Tyr Asp Ala Asn Val Asp Ala Ser Phe Val Asp Ala Glu Ser Asp 245 250 255 Ser Glu Gly Ser Ser Phe Trp Ala Phe Glu Ser Asn Ser Tyr Tyr Leu 260 265 270 Gly Ser Ala Pro Leu Phe Leu Asn Asp Leu Leu Ala Lys Trp Ala Pro 275 280 285 Asp Leu Asp Gln Ser Asp Gly Val Ile Phe Ala Val Pro Asp Arg Asp 290 295 300 Leu Leu Ile Ala Arg Pro Val Thr Thr Gly Glu Asp Leu Met Asn Gly 305 310 315 320 Ile Thr Ala Met Val Arg Ile Ala Met Arg Phe Gly Leu Gly Asn Pro 325 330 335 Thr Ser Ile Ser Pro Arg Leu His Leu Leu Arg Asp Asn Gln Val Thr 340 345 350 Thr Phe Thr Asp Phe Arg Val Val Ser Pro Glu Met Glu Ala Glu Trp 355 360 365 Glu Asp Ser Ala Phe Asp Ala Pro Pro Ala Gly Ala Ile Gly Ile Glu 370 375 380 Val Arg Pro Asp Pro Tyr Leu Met Glu Arg Leu Gln Gln Gly Gly Phe 385 390 395 400 Gly Asp Phe Gly Asp Phe Gly Lys Pro Arg Asp Leu Asp Met 405 410 <210> 159 <211> 730 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(700) <223> RXA01544 <400> 159 ctagatctat aacgaggatc ggcgctactt taagcatgtt tgtgctgttg gcgccgattt 60 tttcatagct gtacacacat aaggcaacag gagaaataca gtg aaa ctt gac gac 115 Val Lys Leu Asp Asp 1 5 gct atg gtc atg atc gaa cag cgc ctg gtc aaa ggt cgc ggc gca acc 163 Ala Met Val Met Ile Glu Gln Arg Leu Val Lys Gly Arg Gly Ala Thr 10 15 20 aag acg caa cta gca ccc tat gag cat atc cag cgc aat att gca gcc 211 Lys Thr Gln Leu Ala Pro Tyr Glu His Ile Gln Arg Asn Ile Ala Ala 25 30 35 cga ggg ttg aga gcc gat gac gga ggc tcg tgc ttc ggt tat ggg gat 259 Arg Gly Leu Arg Ala Asp Asp Gly Gly Ser Cys Phe Gly Tyr Gly Asp 40 45 50 gcg tcg ctg agt aat gac gat gta gca act gct gca gaa gat att cag 307 Ala Ser Leu Ser Asn Asp Asp Val Ala Thr Ala Ala Glu Asp Ile Gln 55 60 65 gat ttg ttt gcg tgc ggg cat acg gtt atc tca gcg att gtc gtt ttt 355 Asp Leu Phe Ala Cys Gly His Thr Val Ile Ser Ala Ile Val Val Phe 70 75 80 85 gat aag agc tat ctc agt gag cat gga atc atg agc ttt gat ccg aac 403 Asp Lys Ser Tyr Leu Ser Glu His Gly Ile Met Ser Phe Asp Pro Asn 90 95 100 tat ttt ggt cag gat att tat gcg gac acc cat cca gag att gat ctc 451 Tyr Phe Gly Gln Asp Ile Tyr Ala Asp Thr His Pro Glu Ile Asp Leu 105 110 115 atg gaa ttg cgt tta gcc gtg atg aat ggg ctc ttg ggg ctt gag gga 499 Met Glu Leu Arg Leu Ala Val Met Asn Gly Leu Leu Gly Leu Glu Gly 120 125 130 acg ttt ttt gag gat atg cgt tat gtc gca tct atc gag gtg agc cgg 547 Thr Phe Phe Glu Asp Met Arg Tyr Val Ala Ser Ile Glu Val Ser Arg 135 140 145 agc tat gtc tat gcg cac ata atg atg gcg gat gca ggc gtt gac gat 595 Ser Tyr Val Tyr Ala His Ile Met Met Ala Asp Ala Gly Val Asp Asp 150 155 160 165 gca cgc ggt aat gca cag gtg aag att acg gac acc gaa cga gtg ctg 643 Ala Arg Gly Asn Ala Gln Val Lys Ile Thr Asp Thr Glu Arg Val Leu 170 175 180 ttt aga cgt ggt gtt gaa tcc cgg ttt gtg gag caa gag gca cgc aac 691 Phe Arg Arg Gly Val Glu Ser Arg Phe Val Glu Gln Glu Ala Arg Asn 185 190 195 gtc gtg ctt tagccaaggt gaggcatcaa gagaagcaac 730 Val Val Leu 200 <210> 160 <211> 200 <212> PRT <213> Corynebacterium glutamicum <400> 160 Val Lys Leu Asp Asp Ala Met Val Met Ile Glu Gln Arg Leu Val Lys 1 5 10 15 Gly Arg Gly Ala Thr Lys Thr Gln Leu Ala Pro Tyr Glu His Ile Gln 20 25 30 Arg Asn Ile Ala Ala Arg Gly Leu Arg Ala Asp Asp Gly Gly Ser Cys 35 40 45 Phe Gly Tyr Gly Asp Ala Ser Leu Ser Asn Asp Asp Val Ala Thr Ala 50 55 60 Ala Glu Asp Ile Gln Asp Leu Phe Ala Cys Gly His Thr Val Ile Ser 65 70 75 80 Ala Ile Val Val Phe Asp Lys Ser Tyr Leu Ser Glu His Gly Ile Met 85 90 95 Ser Phe Asp Pro Asn Tyr Phe Gly Gln Asp Ile Tyr Ala Asp Thr His 100 105 110 Pro Glu Ile Asp Leu Met Glu Leu Arg Leu Ala Val Met Asn Gly Leu 115 120 125 Leu Gly Leu Glu Gly Thr Phe Phe Glu Asp Met Arg Tyr Val Ala Ser 130 135 140 Ile Glu Val Ser Arg Ser Tyr Val Tyr Ala His Ile Met Met Ala Asp 145 150 155 160 Ala Gly Val Asp Asp Ala Arg Gly Asn Ala Gln Val Lys Ile Thr Asp 165 170 175 Thr Glu Arg Val Leu Phe Arg Arg Gly Val Glu Ser Arg Phe Val Glu 180 185 190 Gln Glu Ala Arg Asn Val Val Leu 195 200 <210> 161 <211> 1138 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1108) <223> RXA01548 <400> 161 ggcgtgcgag ctgctggttg gcgcttgtgc accccgtttt tgtgtaataa cttatattct 60 agaaacttca ataacttagt aactttaaaa ggggtttaat atg gct gag aat aat 115 Met Ala Glu Asn Asn 1 5 ggc ggg tcg gat gac ctt aag ccc atc tct gtc gat ggg gtc gtc aat 163 Gly Gly Ser Asp Asp Leu Lys Pro Ile Ser Val Asp Gly Val Val Asn 10 15 20 ggg gaa gtg cgc agc gac aaa gaa aag cag gcg ttc gag aag att acc 211 Gly Glu Val Arg Ser Asp Lys Glu Lys Gln Ala Phe Glu Lys Ile Thr 25 30 35 ggt gat gat ctg cgt cgt cgt gca gaa caa atc cgt aaa cgt cgt tta 259 Gly Asp Asp Leu Arg Arg Arg Ala Glu Gln Ile Arg Lys Arg Arg Leu 40 45 50 gca aaa gcg caa gaa gat gca cgt aag cgt aag cca ttg ttt ggt ttg 307 Ala Lys Ala Gln Glu Asp Ala Arg Lys Arg Lys Pro Leu Phe Gly Leu 55 60 65 ggt cgt atc gct gtc aca gta ctg gct ggc gcc gta ttt att ggt aca 355 Gly Arg Ile Ala Val Thr Val Leu Ala Gly Ala Val Phe Ile Gly Thr 70 75 80 85 acg ttg tgg atc agt acc acc tcg ggc ggc ttt gac gac aag gtg agt 403 Thr Leu Trp Ile Ser Thr Thr Ser Gly Gly Phe Asp Asp Lys Val Ser 90 95 100 gca aac aat gag cag att gtc act ctg cgt aat gaa gtc aac gac tta 451 Ala Asn Asn Glu Gln Ile Val Thr Leu Arg Asn Glu Val Asn Asp Leu 105 110 115 aaa aac act gca gag aca atg ccc aaa aaa gag act ctt gct agt caa 499 Lys Asn Thr Ala Glu Thr Met Pro Lys Lys Glu Thr Leu Ala Ser Gln 120 125 130 ttt gac gca gca acc tca cgt gca cag aat gtg gct gac tta cag aat 547 Phe Asp Ala Ala Thr Ser Arg Ala Gln Asn Val Ala Asp Leu Gln Asn 135 140 145 cag tta gcc ggc att att acc agt gtt gat gat gat gcc gcg acc gag 595 Gln Leu Ala Gly Ile Ile Thr Ser Val Asp Asp Asp Ala Ala Thr Glu 150 155 160 165 cag ttc aag aca att gtt gat gag ctg aaa ccg aaa ttc acg gtc tct 643 Gln Phe Lys Thr Ile Val Asp Glu Leu Lys Pro Lys Phe Thr Val Ser 170 175 180 gct ggt acg aca ggt gaa ttt cct gcg gcg ggt cgt tgg tac cag cca 691 Ala Gly Thr Thr Gly Glu Phe Pro Ala Ala Gly Arg Trp Tyr Gln Pro 185 190 195 caa gaa gtt gtt gtc gga gat aac aac cga ccc acc tgg gcg ccg atg 739 Gln Glu Val Val Val Gly Asp Asn Asn Arg Pro Thr Trp Ala Pro Met 200 205 210 ggg gct gag tcc tgg gga tgg act gtg acc cct aca ctg tcg atg tca 787 Gly Ala Glu Ser Trp Gly Trp Thr Val Thr Pro Thr Leu Ser Met Ser 215 220 225 gat acc gag cac gtt gtg gtg atg tgg gag gcc cgc ttg acc gga ggt 835 Asp Thr Glu His Val Val Val Met Trp Glu Ala Arg Leu Thr Gly Gly 230 235 240 245 gag cgt gac ggt gcg ctg ttg gcg tgg gtg aca gcc gat tac aac atc 883 Glu Arg Asp Gly Ala Leu Leu Ala Trp Val Thr Ala Asp Tyr Asn Ile 250 255 260 aac acc ggc gtg ttt agc tcg ctg gcg ttg gcg cat acc tat gaa gga 931 Asn Thr Gly Val Phe Ser Ser Leu Ala Leu Ala His Thr Tyr Glu Gly 265 270 275 cac cag cgt att ggt gca acc acc tca cca agt gaa ttt ggt gcc cac 979 His Gln Arg Ile Gly Ala Thr Thr Ser Pro Ser Glu Phe Gly Ala His 280 285 290 ggc aca aat gca gag gcg agc gct gca cgt gct ggc agt gaa ggc ggg 1027 Gly Thr Asn Ala Glu Ala Ser Ala Ala Arg Ala Gly Ser Glu Gly Gly 295 300 305 ggg ctt gag ggc gag gct att ttc gtt gat gag ctg cag cgg gca cta 1075 Gly Leu Glu Gly Glu Ala Ile Phe Val Asp Glu Leu Gln Arg Ala Leu 310 315 320 325 gag atc gct cag ctg aac aaa cag gag aac aga taatgacgac acgaaatgta 1128 Glu Ile Ala Gln Leu Asn Lys Gln Glu Asn Arg 330 335 gataaccaga 1138 <210> 162 <211> 336 <212> PRT <213> Corynebacterium glutamicum <400> 162 Met Ala Glu Asn Asn Gly Gly Ser Asp Asp Leu Lys Pro Ile Ser Val 1 5 10 15 Asp Gly Val Val Asn Gly Glu Val Arg Ser Asp Lys Glu Lys Gln Ala 20 25 30 Phe Glu Lys Ile Thr Gly Asp Asp Leu Arg Arg Arg Ala Glu Gln Ile 35 40 45 Arg Lys Arg Arg Leu Ala Lys Ala Gln Glu Asp Ala Arg Lys Arg Lys 50 55 60 Pro Leu Phe Gly Leu Gly Arg Ile Ala Val Thr Val Leu Ala Gly Ala 65 70 75 80 Val Phe Ile Gly Thr Thr Leu Trp Ile Ser Thr Thr Ser Gly Gly Phe 85 90 95 Asp Asp Lys Val Ser Ala Asn Asn Glu Gln Ile Val Thr Leu Arg Asn 100 105 110 Glu Val Asn Asp Leu Lys Asn Thr Ala Glu Thr Met Pro Lys Lys Glu 115 120 125 Thr Leu Ala Ser Gln Phe Asp Ala Ala Thr Ser Arg Ala Gln Asn Val 130 135 140 Ala Asp Leu Gln Asn Gln Leu Ala Gly Ile Ile Thr Ser Val Asp Asp 145 150 155 160 Asp Ala Ala Thr Glu Gln Phe Lys Thr Ile Val Asp Glu Leu Lys Pro 165 170 175 Lys Phe Thr Val Ser Ala Gly Thr Thr Gly Glu Phe Pro Ala Ala Gly 180 185 190 Arg Trp Tyr Gln Pro Gln Glu Val Val Val Gly Asp Asn Asn Arg Pro 195 200 205 Thr Trp Ala Pro Met Gly Ala Glu Ser Trp Gly Trp Thr Val Thr Pro 210 215 220 Thr Leu Ser Met Ser Asp Thr Glu His Val Val Val Met Trp Glu Ala 225 230 235 240 Arg Leu Thr Gly Gly Glu Arg Asp Gly Ala Leu Leu Ala Trp Val Thr 245 250 255 Ala Asp Tyr Asn Ile Asn Thr Gly Val Phe Ser Ser Leu Ala Leu Ala 260 265 270 His Thr Tyr Glu Gly His Gln Arg Ile Gly Ala Thr Thr Ser Pro Ser 275 280 285 Glu Phe Gly Ala His Gly Thr Asn Ala Glu Ala Ser Ala Ala Arg Ala 290 295 300 Gly Ser Glu Gly Gly Gly Leu Glu Gly Glu Ala Ile Phe Val Asp Glu 305 310 315 320 Leu Gln Arg Ala Leu Glu Ile Ala Gln Leu Asn Lys Gln Glu Asn Arg 325 330 335 <210> 163 <211> 1789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1759) <223> RXA01549 <400> 163 cacagcttga tcaggcagtg gaaaatactc aggttgccca aggttccgat gctgttgaat 60 tccgtttcta gatttttttt attgattgtg agagtgcatt gtg gct aat gat ttt 115 Val Ala Asn Asp Phe 1 5 ata gaa cca aat gat gcc ccc gat gca cct gat aat ggt gac tcg gga 163 Ile Glu Pro Asn Asp Ala Pro Asp Ala Pro Asp Asn Gly Asp Ser Gly 10 15 20 agc tcg ggg ttt gtt gat gaa gca aaa gat aag acc cgc tca gct gca 211 Ser Ser Gly Phe Val Asp Glu Ala Lys Asp Lys Thr Arg Ser Ala Ala 25 30 35 caa ggc tta ggt tat ggc gca cta cgt gta ggt ttt ggt act gca gca 259 Gln Gly Leu Gly Tyr Gly Ala Leu Arg Val Gly Phe Gly Thr Ala Ala 40 45 50 ctt gca gcc aat ggt gct cgc tct atg ggt aat ttg gct aaa aac ctg 307 Leu Ala Ala Asn Gly Ala Arg Ser Met Gly Asn Leu Ala Lys Asn Leu 55 60 65 tgg aca cga atg atg ggg ctt gcc ctg tct gcc ggt act ggt atc tct 355 Trp Thr Arg Met Met Gly Leu Ala Leu Ser Ala Gly Thr Gly Ile Ser 70 75 80 85 gct gcc aca ggt ggc atg atc act gca cgt gta ggc gca atg ctg gca 403 Ala Ala Thr Gly Gly Met Ile Thr Ala Arg Val Gly Ala Met Leu Ala 90 95 100 ggt aca ggc tcg gtg ttg tcg tcg gtg acg act att gcg ttg att gtg 451 Gly Thr Gly Ser Val Leu Ser Ser Val Thr Thr Ile Ala Leu Ile Val 105 110 115 tcg atg att gtg gtg ccg gca ggt cga aaa gac ggc att atc gag ttg 499 Ser Met Ile Val Val Pro Ala Gly Arg Lys Asp Gly Ile Ile Glu Leu 120 125 130 tgt gag ccg cca gta acg gcc aac ccg ttt acc att gac gca ggt gat 547 Cys Glu Pro Pro Val Thr Ala Asn Pro Phe Thr Ile Asp Ala Gly Asp 135 140 145 atg act gag aac gcg aag ttg gtg tac ggt gcg ctg tcg tat ctt ggg 595 Met Thr Glu Asn Ala Lys Leu Val Tyr Gly Ala Leu Ser Tyr Leu Gly 150 155 160 165 atg aat gat caa aat atc gcc ggt gtc ttg ggc aac ttt gag aca gaa 643 Met Asn Asp Gln Asn Ile Ala Gly Val Leu Gly Asn Phe Glu Thr Glu 170 175 180 tca ggt atc gac ccg act gcg gtg gag ggt att ttt gat gaa cca aat 691 Ser Gly Ile Asp Pro Thr Ala Val Glu Gly Ile Phe Asp Glu Pro Asn 185 190 195 acc atc ggt cct cgg aag aga gct gcg tgg gat aag aac ttt gaa cct 739 Thr Ile Gly Pro Arg Lys Arg Ala Ala Trp Asp Lys Asn Phe Glu Pro 200 205 210 cag ccg atg ggt att ggg ctt ggg cag tgg aca gca ggg cgc aca cag 787 Gln Pro Met Gly Ile Gly Leu Gly Gln Trp Thr Ala Gly Arg Thr Gln 215 220 225 atg ttg cta gat ttt gcc gcc gat aga aac cga gac tgg cat tac atc 835 Met Leu Leu Asp Phe Ala Ala Asp Arg Asn Arg Asp Trp His Tyr Ile 230 235 240 245 gac gtg cag ctt gca ttt gct att agt ggc gat aat gaa agc gat cgc 883 Asp Val Gln Leu Ala Phe Ala Ile Ser Gly Asp Asn Glu Ser Asp Arg 250 255 260 aag gtt ttt ctg gaa atg gtt gat aat aaa aac tcc agt agc aat agc 931 Lys Val Phe Leu Glu Met Val Asp Asn Lys Asn Ser Ser Ser Asn Ser 265 270 275 ccc acc gca gcg tcc gag tac ttc ctg cgt gag tgg gag cgc ccg gca 979 Pro Thr Ala Ala Ser Glu Tyr Phe Leu Arg Glu Trp Glu Arg Pro Ala 280 285 290 gat gtc gca ggt aat gca ccc att cgt gca gag caa gca tct aag tgg 1027 Asp Val Ala Gly Asn Ala Pro Ile Arg Ala Glu Gln Ala Ser Lys Trp 295 300 305 tac gcg cag atg ggt ggt tgg caa aag aac tca acc ttg ggt gag tct 1075 Tyr Ala Gln Met Gly Gly Trp Gln Lys Asn Ser Thr Leu Gly Glu Ser 310 315 320 325 gtg atc gct atg gct gat ggt gca gca gca aaa tcc acg gcg cgt gat 1123 Val Ile Ala Met Ala Asp Gly Ala Ala Ala Lys Ser Thr Ala Arg Asp 330 335 340 gag cag gat gct ctt aat gat tgt cct gaa gag gac cgc acc tca ggt 1171 Glu Gln Asp Ala Leu Asn Asp Cys Pro Glu Glu Asp Arg Thr Ser Gly 345 350 355 gga aat acg tcc gct gca gaa gca atg gtg act att tca cat cct tat 1219 Gly Asn Thr Ser Ala Ala Glu Ala Met Val Thr Ile Ser His Pro Tyr 360 365 370 ctg gct gat tct cgt ggc aat gac ggt act gat att tac cgc tat atc 1267 Leu Ala Asp Ser Arg Gly Asn Asp Gly Thr Asp Ile Tyr Arg Tyr Ile 375 380 385 cat gat gaa gtg ctc acc ggt gat ccg tat tac gca tcc tgt gac cgt 1315 His Asp Glu Val Leu Thr Gly Asp Pro Tyr Tyr Ala Ser Cys Asp Arg 390 395 400 405 ggc gtt gct acc gct att cgc tgg tcg ggc acg gat gat acg ttc cca 1363 Gly Val Ala Thr Ala Ile Arg Trp Ser Gly Thr Asp Asp Thr Phe Pro 410 415 420 gca ggt cca aca gca gca cag tat gaa tac gtt gtg ggc aca gga tcg 1411 Ala Gly Pro Thr Ala Ala Gln Tyr Glu Tyr Val Val Gly Thr Gly Ser 425 430 435 ggc cgt tgg gag gaa atc ggc aat ctt gcc acc atg tca gag aac gat 1459 Gly Arg Trp Glu Glu Ile Gly Asn Leu Ala Thr Met Ser Glu Asn Asp 440 445 450 ttg tta cct ggc gat gtg ctt ctt ggt gca ccg aat cac gtt gcg atg 1507 Leu Leu Pro Gly Asp Val Leu Leu Gly Ala Pro Asn His Val Ala Met 455 460 465 tat gtc agc aat gag gtt gtt gtg gac atg ttg ggc cct ggt aat gca 1555 Tyr Val Ser Asn Glu Val Val Val Asp Met Leu Gly Pro Gly Asn Ala 470 475 480 485 gag cct aat gca gct att ggt cat gca tcg ttg aat gac cgc tca cct 1603 Glu Pro Asn Ala Ala Ile Gly His Ala Ser Leu Asn Asp Arg Ser Pro 490 495 500 ggt ctg gat acc ttg agt ctg gat gga tgg ggc gtg aac ttc aag gtg 1651 Gly Leu Asp Thr Leu Ser Leu Asp Gly Trp Gly Val Asn Phe Lys Val 505 510 515 ttc cgc aac acc cag gct gag aca aac tca gtg ttc tct ggt gta cag 1699 Phe Arg Asn Thr Gln Ala Glu Thr Asn Ser Val Phe Ser Gly Val Gln 520 525 530 att ccg gct ggt aaa gaa att ggc gaa atg act aac cca act cga act 1747 Ile Pro Ala Gly Lys Glu Ile Gly Glu Met Thr Asn Pro Thr Arg Thr 535 540 545 act cct gca gga taagtttttt tcatcgctgg gttggtgtga 1789 Thr Pro Ala Gly 550 <210> 164 <211> 553 <212> PRT <213> Corynebacterium glutamicum <400> 164 Val Ala Asn Asp Phe Ile Glu Pro Asn Asp Ala Pro Asp Ala Pro Asp 1 5 10 15 Asn Gly Asp Ser Gly Ser Ser Gly Phe Val Asp Glu Ala Lys Asp Lys 20 25 30 Thr Arg Ser Ala Ala Gln Gly Leu Gly Tyr Gly Ala Leu Arg Val Gly 35 40 45 Phe Gly Thr Ala Ala Leu Ala Ala Asn Gly Ala Arg Ser Met Gly Asn 50 55 60 Leu Ala Lys Asn Leu Trp Thr Arg Met Met Gly Leu Ala Leu Ser Ala 65 70 75 80 Gly Thr Gly Ile Ser Ala Ala Thr Gly Gly Met Ile Thr Ala Arg Val 85 90 95 Gly Ala Met Leu Ala Gly Thr Gly Ser Val Leu Ser Ser Val Thr Thr 100 105 110 Ile Ala Leu Ile Val Ser Met Ile Val Val Pro Ala Gly Arg Lys Asp 115 120 125 Gly Ile Ile Glu Leu Cys Glu Pro Pro Val Thr Ala Asn Pro Phe Thr 130 135 140 Ile Asp Ala Gly Asp Met Thr Glu Asn Ala Lys Leu Val Tyr Gly Ala 145 150 155 160 Leu Ser Tyr Leu Gly Met Asn Asp Gln Asn Ile Ala Gly Val Leu Gly 165 170 175 Asn Phe Glu Thr Glu Ser Gly Ile Asp Pro Thr Ala Val Glu Gly Ile 180 185 190 Phe Asp Glu Pro Asn Thr Ile Gly Pro Arg Lys Arg Ala Ala Trp Asp 195 200 205 Lys Asn Phe Glu Pro Gln Pro Met Gly Ile Gly Leu Gly Gln Trp Thr 210 215 220 Ala Gly Arg Thr Gln Met Leu Leu Asp Phe Ala Ala Asp Arg Asn Arg 225 230 235 240 Asp Trp His Tyr Ile Asp Val Gln Leu Ala Phe Ala Ile Ser Gly Asp 245 250 255 Asn Glu Ser Asp Arg Lys Val Phe Leu Glu Met Val Asp Asn Lys Asn 260 265 270 Ser Ser Ser Asn Ser Pro Thr Ala Ala Ser Glu Tyr Phe Leu Arg Glu 275 280 285 Trp Glu Arg Pro Ala Asp Val Ala Gly Asn Ala Pro Ile Arg Ala Glu 290 295 300 Gln Ala Ser Lys Trp Tyr Ala Gln Met Gly Gly Trp Gln Lys Asn Ser 305 310 315 320 Thr Leu Gly Glu Ser Val Ile Ala Met Ala Asp Gly Ala Ala Ala Lys 325 330 335 Ser Thr Ala Arg Asp Glu Gln Asp Ala Leu Asn Asp Cys Pro Glu Glu 340 345 350 Asp Arg Thr Ser Gly Gly Asn Thr Ser Ala Ala Glu Ala Met Val Thr 355 360 365 Ile Ser His Pro Tyr Leu Ala Asp Ser Arg Gly Asn Asp Gly Thr Asp 370 375 380 Ile Tyr Arg Tyr Ile His Asp Glu Val Leu Thr Gly Asp Pro Tyr Tyr 385 390 395 400 Ala Ser Cys Asp Arg Gly Val Ala Thr Ala Ile Arg Trp Ser Gly Thr 405 410 415 Asp Asp Thr Phe Pro Ala Gly Pro Thr Ala Ala Gln Tyr Glu Tyr Val 420 425 430 Val Gly Thr Gly Ser Gly Arg Trp Glu Glu Ile Gly Asn Leu Ala Thr 435 440 445 Met Ser Glu Asn Asp Leu Leu Pro Gly Asp Val Leu Leu Gly Ala Pro 450 455 460 Asn His Val Ala Met Tyr Val Ser Asn Glu Val Val Val Asp Met Leu 465 470 475 480 Gly Pro Gly Asn Ala Glu Pro Asn Ala Ala Ile Gly His Ala Ser Leu 485 490 495 Asn Asp Arg Ser Pro Gly Leu Asp Thr Leu Ser Leu Asp Gly Trp Gly 500 505 510 Val Asn Phe Lys Val Phe Arg Asn Thr Gln Ala Glu Thr Asn Ser Val 515 520 525 Phe Ser Gly Val Gln Ile Pro Ala Gly Lys Glu Ile Gly Glu Met Thr 530 535 540 Asn Pro Thr Arg Thr Thr Pro Ala Gly 545 550 <210> 165 <211> 2272 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2242) <223> RXA01554 <400> 165 tggcttaaac cttatttgta gttgtcaata aatatgaaat tccttagcaa cttgtttaaa 60 tagacgtata aacaagtttg aaaaaggaag gttatccatc ttg aaa aag cat gtg 115 Leu Lys Lys His Val 1 5 acc tca gcc gtt acc gcc gtg gtg acg gct ttt tca acg gct gcg ctt 163 Thr Ser Ala Val Thr Ala Val Val Thr Ala Phe Ser Thr Ala Ala Leu 10 15 20 ggt tta agt att gcc gtt tct cct gct gtt gcc caa gtg gct aat cca 211 Gly Leu Ser Ile Ala Val Ser Pro Ala Val Ala Gln Val Ala Asn Pro 25 30 35 gct cca gat ctt tct gcg ccg tat aca tgg gtg gaa gag ttt gat tcc 259 Ala Pro Asp Leu Ser Ala Pro Tyr Thr Trp Val Glu Glu Phe Asp Ser 40 45 50 gag gat gct ctc aaa ggg tgg aac att ttc cgc cag cca gat tat ggc 307 Glu Asp Ala Leu Lys Gly Trp Asn Ile Phe Arg Gln Pro Asp Tyr Gly 55 60 65 agc gac aaa gtt ctc tat acc gaa gat gct tta agt atc gaa gat ggc 355 Ser Asp Lys Val Leu Tyr Thr Glu Asp Ala Leu Ser Ile Glu Asp Gly 70 75 80 85 aag ctc acc atc acc act cag cgc cac tgc gtt gac gaa gac ttc gcg 403 Lys Leu Thr Ile Thr Thr Gln Arg His Cys Val Asp Glu Asp Phe Ala 90 95 100 atc agt gat cct gtc aac cgc gga aag ctc aat gac agc acc gcg caa 451 Ile Ser Asp Pro Val Asn Arg Gly Lys Leu Asn Asp Ser Thr Ala Gln 105 110 115 gtt gaa cct tgt gct cca ggt cag ttt gaa aag ttc acc agt gcg cgc 499 Val Glu Pro Cys Ala Pro Gly Gln Phe Glu Lys Phe Thr Ser Ala Arg 120 125 130 atc gtc act ccg aaa att gct cgt gga gag ttc gac ctt tct gtc act 547 Ile Val Thr Pro Lys Ile Ala Arg Gly Glu Phe Asp Leu Ser Val Thr 135 140 145 gca act ctt aac acc ggt ggc gtc gaa ggt gtc cga agt gcc att tgg 595 Ala Thr Leu Asn Thr Gly Gly Val Glu Gly Val Arg Ser Ala Ile Trp 150 155 160 165 atg caa aac ggt gaa cag gcg tgt tcc tca gca acc aac aat ggc ctc 643 Met Gln Asn Gly Glu Gln Ala Cys Ser Ser Ala Thr Asn Asn Gly Leu 170 175 180 tac gga gaa cta gac ctg gta gag cac ttt tct tac gat ctt cgc tcg 691 Tyr Gly Glu Leu Asp Leu Val Glu His Phe Ser Tyr Asp Leu Arg Ser 185 190 195 cca tgg tct cca tca aac acc cac ttg ggt tgt gat cct gaa agt gtc 739 Pro Trp Ser Pro Ser Asn Thr His Leu Gly Cys Asp Pro Glu Ser Val 200 205 210 aac ggc acc aac cgt gca cct cgt gaa ctt aaa cta gat gag tca ctc 787 Asn Gly Thr Asn Arg Ala Pro Arg Glu Leu Lys Leu Asp Glu Ser Leu 215 220 225 gat ggc gtg gag cac acc tgg act gtg agc acc acc cgc gac ggc gtt 835 Asp Gly Val Glu His Thr Trp Thr Val Ser Thr Thr Arg Asp Gly Val 230 235 240 245 gag tac ttc att gat gat gag gcg att aac cgc cag tca tgg cgc aac 883 Glu Tyr Phe Ile Asp Asp Glu Ala Ile Asn Arg Gln Ser Trp Arg Asn 250 255 260 gat gtc act ttg ggg cat gcc gaa att gat gat ttc ggg atc tcc gcg 931 Asp Val Thr Leu Gly His Ala Glu Ile Asp Asp Phe Gly Ile Ser Ala 265 270 275 cag acg ttt gat gag atc gtc gac cgc gaa tgg act ctc act ctt aat 979 Gln Thr Phe Asp Glu Ile Val Asp Arg Glu Trp Thr Leu Thr Leu Asn 280 285 290 caa aag gta gaa agc gcc gac tgg gca aaa cca cgt tcc tct gag gaa 1027 Gln Lys Val Glu Ser Ala Asp Trp Ala Lys Pro Arg Ser Ser Glu Glu 295 300 305 gat ttc cca gtc cgg tcc atg gtg att gac cgc atc gag gtc acc gga 1075 Asp Phe Pro Val Arg Ser Met Val Ile Asp Arg Ile Glu Val Thr Gly 310 315 320 325 tct ccc gca gta tct gaa gac acc ccc atg cca gat acc acc cag ctt 1123 Ser Pro Ala Val Ser Glu Asp Thr Pro Met Pro Asp Thr Thr Gln Leu 330 335 340 ttg acc caa gac act ctg gaa tac ctc ggt cgc atg cca gtg ctg gaa 1171 Leu Thr Gln Asp Thr Leu Glu Tyr Leu Gly Arg Met Pro Val Leu Glu 345 350 355 cgc tac gag cca gca agt gct gat ttt gcc gat ggc cgc agg cct tcc 1219 Arg Tyr Glu Pro Ala Ser Ala Asp Phe Ala Asp Gly Arg Arg Pro Ser 360 365 370 tgg aac tac ttc aat ttg aag gaa tcg tgg cag aat cca gaa ctc gag 1267 Trp Asn Tyr Phe Asn Leu Lys Glu Ser Trp Gln Asn Pro Glu Leu Glu 375 380 385 caa cgc cca gaa gct gtc gaa ttc gtt gat gga cgc atg gat atc gtg 1315 Gln Arg Pro Glu Ala Val Glu Phe Val Asp Gly Arg Met Asp Ile Val 390 395 400 405 acc cgt cgc cac tgt ctg gcc acc act gat gac atc gcc act ccg gaa 1363 Thr Arg Arg His Cys Leu Ala Thr Thr Asp Asp Ile Ala Thr Pro Glu 410 415 420 aac gca cag gag gaa ccg tgc gcg ccg ggt gag gtg aca cgc tac agc 1411 Asn Ala Gln Glu Glu Pro Cys Ala Pro Gly Glu Val Thr Arg Tyr Ser 425 430 435 tca gcg cgt gtc cac ctt cca gag atc ccc gcc ggc aac ttc cgg ctc 1459 Ser Ala Arg Val His Leu Pro Glu Ile Pro Ala Gly Asn Phe Arg Leu 440 445 450 acc gtg cgc gca cgg gcg cag tcc gaa gag ctt gtc gac ggc gtc cgc 1507 Thr Val Arg Ala Arg Ala Gln Ser Glu Glu Leu Val Asp Gly Val Arg 455 460 465 ccc gct atc tgg atg cag aac aat acc aac ttc tgt gct gac aac gat 1555 Pro Ala Ile Trp Met Gln Asn Asn Thr Asn Phe Cys Ala Asp Asn Asp 470 475 480 485 gga cgc cct tat ggt gaa ctg gat att act gag ttc tac agc tct cgt 1603 Gly Arg Pro Tyr Gly Glu Leu Asp Ile Thr Glu Phe Tyr Ser Ser Arg 490 495 500 gtg aac acc cag tac tcg gca gta cac ctt gga tgt gct ggc aac cgc 1651 Val Asn Thr Gln Tyr Ser Ala Val His Leu Gly Cys Ala Gly Asn Arg 505 510 515 cca gag atg aag ctt cgc caa atg gaa atg gaa gag tcc atg ttt ggg 1699 Pro Glu Met Lys Leu Arg Gln Met Glu Met Glu Glu Ser Met Phe Gly 520 525 530 gat tgg cat gac tgg ggc gtc gaa gtc ttc gac ggc cag atc gta ttc 1747 Asp Trp His Asp Trp Gly Val Glu Val Phe Asp Gly Gln Ile Val Phe 535 540 545 acc att gac ggc aag gca gta act tcc tct ggc aaa gat gtc ttt ggc 1795 Thr Ile Asp Gly Lys Ala Val Thr Ser Ser Gly Lys Asp Val Phe Gly 550 555 560 565 aac tct gtt acc cca gcc gct gca cct ctt cgc ccc gcg cac ttc aag 1843 Asn Ser Val Thr Pro Ala Ala Ala Pro Leu Arg Pro Ala His Phe Lys 570 575 580 ttg tcg gaa gag gaa tac cgt gaa gtc atc ggg cag cct tgg cac ctt 1891 Leu Ser Glu Glu Glu Tyr Arg Glu Val Ile Gly Gln Pro Trp His Leu 585 590 595 att ttg aac acc atg gtg gag cag tct ggc aaa gac agc tgg att aca 1939 Ile Leu Asn Thr Met Val Glu Gln Ser Gly Lys Asp Ser Trp Ile Thr 600 605 610 gcg gtc gac aat aac gag gcg ttc cca gaa cac cgc ttc caa att gac 1987 Ala Val Asp Asn Asn Glu Ala Phe Pro Glu His Arg Phe Gln Ile Asp 615 620 625 cat gtg gca gta gat atc gag tct gac tct gtg gac aat gta tgg cct 2035 His Val Ala Val Asp Ile Glu Ser Asp Ser Val Asp Asn Val Trp Pro 630 635 640 645 gac gct gcg aat gaa atc cca gac aat gtt ggt att gaa gac tct gat 2083 Asp Ala Ala Asn Glu Ile Pro Asp Asn Val Gly Ile Glu Asp Ser Asp 650 655 660 gat ggc agc gac ctg gag gtt ggt tcg acc gga agc tct aca gct gag 2131 Asp Gly Ser Asp Leu Glu Val Gly Ser Thr Gly Ser Ser Thr Ala Glu 665 670 675 acc gtg agc tgg atc tcg ttg ttc acc gcg ttg agc tcg ctg gtc ttc 2179 Thr Val Ser Trp Ile Ser Leu Phe Thr Ala Leu Ser Ser Leu Val Phe 680 685 690 aca ctg gct ctc aat caa gaa gca ttg cag aat ttg att aat cag ttc 2227 Thr Leu Ala Leu Asn Gln Glu Ala Leu Gln Asn Leu Ile Asn Gln Phe 695 700 705 atg aga cag ttc aag taatccttgt gggcgctttg tctacttcac 2272 Met Arg Gln Phe Lys 710 <210> 166 <211> 714 <212> PRT <213> Corynebacterium glutamicum <400> 166 Leu Lys Lys His Val Thr Ser Ala Val Thr Ala Val Val Thr Ala Phe 1 5 10 15 Ser Thr Ala Ala Leu Gly Leu Ser Ile Ala Val Ser Pro Ala Val Ala 20 25 30 Gln Val Ala Asn Pro Ala Pro Asp Leu Ser Ala Pro Tyr Thr Trp Val 35 40 45 Glu Glu Phe Asp Ser Glu Asp Ala Leu Lys Gly Trp Asn Ile Phe Arg 50 55 60 Gln Pro Asp Tyr Gly Ser Asp Lys Val Leu Tyr Thr Glu Asp Ala Leu 65 70 75 80 Ser Ile Glu Asp Gly Lys Leu Thr Ile Thr Thr Gln Arg His Cys Val 85 90 95 Asp Glu Asp Phe Ala Ile Ser Asp Pro Val Asn Arg Gly Lys Leu Asn 100 105 110 Asp Ser Thr Ala Gln Val Glu Pro Cys Ala Pro Gly Gln Phe Glu Lys 115 120 125 Phe Thr Ser Ala Arg Ile Val Thr Pro Lys Ile Ala Arg Gly Glu Phe 130 135 140 Asp Leu Ser Val Thr Ala Thr Leu Asn Thr Gly Gly Val Glu Gly Val 145 150 155 160 Arg Ser Ala Ile Trp Met Gln Asn Gly Glu Gln Ala Cys Ser Ser Ala 165 170 175 Thr Asn Asn Gly Leu Tyr Gly Glu Leu Asp Leu Val Glu His Phe Ser 180 185 190 Tyr Asp Leu Arg Ser Pro Trp Ser Pro Ser Asn Thr His Leu Gly Cys 195 200 205 Asp Pro Glu Ser Val Asn Gly Thr Asn Arg Ala Pro Arg Glu Leu Lys 210 215 220 Leu Asp Glu Ser Leu Asp Gly Val Glu His Thr Trp Thr Val Ser Thr 225 230 235 240 Thr Arg Asp Gly Val Glu Tyr Phe Ile Asp Asp Glu Ala Ile Asn Arg 245 250 255 Gln Ser Trp Arg Asn Asp Val Thr Leu Gly His Ala Glu Ile Asp Asp 260 265 270 Phe Gly Ile Ser Ala Gln Thr Phe Asp Glu Ile Val Asp Arg Glu Trp 275 280 285 Thr Leu Thr Leu Asn Gln Lys Val Glu Ser Ala Asp Trp Ala Lys Pro 290 295 300 Arg Ser Ser Glu Glu Asp Phe Pro Val Arg Ser Met Val Ile Asp Arg 305 310 315 320 Ile Glu Val Thr Gly Ser Pro Ala Val Ser Glu Asp Thr Pro Met Pro 325 330 335 Asp Thr Thr Gln Leu Leu Thr Gln Asp Thr Leu Glu Tyr Leu Gly Arg 340 345 350 Met Pro Val Leu Glu Arg Tyr Glu Pro Ala Ser Ala Asp Phe Ala Asp 355 360 365 Gly Arg Arg Pro Ser Trp Asn Tyr Phe Asn Leu Lys Glu Ser Trp Gln 370 375 380 Asn Pro Glu Leu Glu Gln Arg Pro Glu Ala Val Glu Phe Val Asp Gly 385 390 395 400 Arg Met Asp Ile Val Thr Arg Arg His Cys Leu Ala Thr Thr Asp Asp 405 410 415 Ile Ala Thr Pro Glu Asn Ala Gln Glu Glu Pro Cys Ala Pro Gly Glu 420 425 430 Val Thr Arg Tyr Ser Ser Ala Arg Val His Leu Pro Glu Ile Pro Ala 435 440 445 Gly Asn Phe Arg Leu Thr Val Arg Ala Arg Ala Gln Ser Glu Glu Leu 450 455 460 Val Asp Gly Val Arg Pro Ala Ile Trp Met Gln Asn Asn Thr Asn Phe 465 470 475 480 Cys Ala Asp Asn Asp Gly Arg Pro Tyr Gly Glu Leu Asp Ile Thr Glu 485 490 495 Phe Tyr Ser Ser Arg Val Asn Thr Gln Tyr Ser Ala Val His Leu Gly 500 505 510 Cys Ala Gly Asn Arg Pro Glu Met Lys Leu Arg Gln Met Glu Met Glu 515 520 525 Glu Ser Met Phe Gly Asp Trp His Asp Trp Gly Val Glu Val Phe Asp 530 535 540 Gly Gln Ile Val Phe Thr Ile Asp Gly Lys Ala Val Thr Ser Ser Gly 545 550 555 560 Lys Asp Val Phe Gly Asn Ser Val Thr Pro Ala Ala Ala Pro Leu Arg 565 570 575 Pro Ala His Phe Lys Leu Ser Glu Glu Glu Tyr Arg Glu Val Ile Gly 580 585 590 Gln Pro Trp His Leu Ile Leu Asn Thr Met Val Glu Gln Ser Gly Lys 595 600 605 Asp Ser Trp Ile Thr Ala Val Asp Asn Asn Glu Ala Phe Pro Glu His 610 615 620 Arg Phe Gln Ile Asp His Val Ala Val Asp Ile Glu Ser Asp Ser Val 625 630 635 640 Asp Asn Val Trp Pro Asp Ala Ala Asn Glu Ile Pro Asp Asn Val Gly 645 650 655 Ile Glu Asp Ser Asp Asp Gly Ser Asp Leu Glu Val Gly Ser Thr Gly 660 665 670 Ser Ser Thr Ala Glu Thr Val Ser Trp Ile Ser Leu Phe Thr Ala Leu 675 680 685 Ser Ser Leu Val Phe Thr Leu Ala Leu Asn Gln Glu Ala Leu Gln Asn 690 695 700 Leu Ile Asn Gln Phe Met Arg Gln Phe Lys 705 710 <210> 167 <211> 1165 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1135) <223> RXA01574 <400> 167 aaaaatccgc acaccccaca ttgctcaaag gaattgacaa ggcgcttcgc aaggccgagt 60 aaggtgggca acgagtcggt gagagtatga ggaatatttg atg agc aac aaa cgc 115 Met Ser Asn Lys Arg 1 5 atc ggt gta gtg atc gtt tcc tac gga cac gaa caa gat gtt gcc aac 163 Ile Gly Val Val Ile Val Ser Tyr Gly His Glu Gln Asp Val Ala Asn 10 15 20 ctg gta gac aca ttt gca gat cag ctg aaa act ggt gac cgc gta gtt 211 Leu Val Asp Thr Phe Ala Asp Gln Leu Lys Thr Gly Asp Arg Val Val 25 30 35 gtc gtg gac aac cgc aaa cct tgg gtg tta aaa gac gcc gtg ggg gag 259 Val Val Asp Asn Arg Lys Pro Trp Val Leu Lys Asp Ala Val Gly Glu 40 45 50 cgc ctg gaa aaa cac ggc gca gag atc atc aac cac gac aac ggt ggt 307 Arg Leu Glu Lys His Gly Ala Glu Ile Ile Asn His Asp Asn Gly Gly 55 60 65 ttc gcc gct ggc tgc aac gtg ggc gca gcg cac atc gtg gat gac gtt 355 Phe Ala Ala Gly Cys Asn Val Gly Ala Ala His Ile Val Asp Asp Val 70 75 80 85 gac ctg ctg ttc ttc ctc aac ccc gac aca gtg atc gac gat ccc acc 403 Asp Leu Leu Phe Phe Leu Asn Pro Asp Thr Val Ile Asp Asp Pro Thr 90 95 100 ctg ttc aat tcg ctg aga cgc gtc gat gaa cag tgg gca gca ttc atg 451 Leu Phe Asn Ser Leu Arg Arg Val Asp Glu Gln Trp Ala Ala Phe Met 105 110 115 ccg tac ctg ctg ctt cct gac agc acc att aac tcc gca ggc aac gcc 499 Pro Tyr Leu Leu Leu Pro Asp Ser Thr Ile Asn Ser Ala Gly Asn Ala 120 125 130 ctg cat att tcc gga ctg tcg tgg gtg act ggt ctg gat gaa aaa cca 547 Leu His Ile Ser Gly Leu Ser Trp Val Thr Gly Leu Asp Glu Lys Pro 135 140 145 gtt gaa ggc tca tct gaa gtt acc gat att tcc att gcc tct ggc gcc 595 Val Glu Gly Ser Ser Glu Val Thr Asp Ile Ser Ile Ala Ser Gly Ala 150 155 160 165 tgc ctt gcc gtg cgc gtg gac tgg tgg aaa cgc ctc ggt ggc atg gaa 643 Cys Leu Ala Val Arg Val Asp Trp Trp Lys Arg Leu Gly Gly Met Glu 170 175 180 gaa ctg tat ttc atg tac cac gaa gac act gac ttc tcc gcc cgc ttg 691 Glu Leu Tyr Phe Met Tyr His Glu Asp Thr Asp Phe Ser Ala Arg Leu 185 190 195 ctg ctg gcc ggc ggt cga att ggt ctc ctg cat tcc gcg tat gtc acc 739 Leu Leu Ala Gly Gly Arg Ile Gly Leu Leu His Ser Ala Tyr Val Thr 200 205 210 cac cat tac gac tac gcc aag ggt gac tac aag tgg att tac atc gaa 787 His His Tyr Asp Tyr Ala Lys Gly Asp Tyr Lys Trp Ile Tyr Ile Glu 215 220 225 cga aac cga cac gtt ttg ctg ctc agc gtg ctg ccg ctt cca ttg ctg 835 Arg Asn Arg His Val Leu Leu Leu Ser Val Leu Pro Leu Pro Leu Leu 230 235 240 245 ttc gtg ctg atc ccg cag atc ctc ggt gtg aac ctg gga ctg tgg gcg 883 Phe Val Leu Ile Pro Gln Ile Leu Gly Val Asn Leu Gly Leu Trp Ala 250 255 260 att gcc gca aag gaa aag agg gtc gga ctc aag gtg aag tcc ctt cgc 931 Ile Ala Ala Lys Glu Lys Arg Val Gly Leu Lys Val Lys Ser Leu Arg 265 270 275 ctc ctg atc cgc gat cta cca gcg att ttc aaa ctg cgt agg agc acg 979 Leu Leu Ile Arg Asp Leu Pro Ala Ile Phe Lys Leu Arg Arg Ser Thr 280 285 290 cag gag ctt gcc gaa ctc aca cca tcg caa tat ctg gca aaa atg gaa 1027 Gln Glu Leu Ala Glu Leu Thr Pro Ser Gln Tyr Leu Ala Lys Met Glu 295 300 305 tgg cgc cta gac aat ccc aac cta ggc aac att gga tcc aac aag att 1075 Trp Arg Leu Asp Asn Pro Asn Leu Gly Asn Ile Gly Ser Asn Lys Ile 310 315 320 325 gtt gcg act gga tat aag acc tat tac aag ttg tgt atg agt atc ctg 1123 Val Ala Thr Gly Tyr Lys Thr Tyr Tyr Lys Leu Cys Met Ser Ile Leu 330 335 340 aaa ttg ctc gct taacacccca taaagagggt gaagatttaa 1165 Lys Leu Leu Ala 345 <210> 168 <211> 345 <212> PRT <213> Corynebacterium glutamicum <400> 168 Met Ser Asn Lys Arg Ile Gly Val Val Ile Val Ser Tyr Gly His Glu 1 5 10 15 Gln Asp Val Ala Asn Leu Val Asp Thr Phe Ala Asp Gln Leu Lys Thr 20 25 30 Gly Asp Arg Val Val Val Val Asp Asn Arg Lys Pro Trp Val Leu Lys 35 40 45 Asp Ala Val Gly Glu Arg Leu Glu Lys His Gly Ala Glu Ile Ile Asn 50 55 60 His Asp Asn Gly Gly Phe Ala Ala Gly Cys Asn Val Gly Ala Ala His 65 70 75 80 Ile Val Asp Asp Val Asp Leu Leu Phe Phe Leu Asn Pro Asp Thr Val 85 90 95 Ile Asp Asp Pro Thr Leu Phe Asn Ser Leu Arg Arg Val Asp Glu Gln 100 105 110 Trp Ala Ala Phe Met Pro Tyr Leu Leu Leu Pro Asp Ser Thr Ile Asn 115 120 125 Ser Ala Gly Asn Ala Leu His Ile Ser Gly Leu Ser Trp Val Thr Gly 130 135 140 Leu Asp Glu Lys Pro Val Glu Gly Ser Ser Glu Val Thr Asp Ile Ser 145 150 155 160 Ile Ala Ser Gly Ala Cys Leu Ala Val Arg Val Asp Trp Trp Lys Arg 165 170 175 Leu Gly Gly Met Glu Glu Leu Tyr Phe Met Tyr His Glu Asp Thr Asp 180 185 190 Phe Ser Ala Arg Leu Leu Leu Ala Gly Gly Arg Ile Gly Leu Leu His 195 200 205 Ser Ala Tyr Val Thr His His Tyr Asp Tyr Ala Lys Gly Asp Tyr Lys 210 215 220 Trp Ile Tyr Ile Glu Arg Asn Arg His Val Leu Leu Leu Ser Val Leu 225 230 235 240 Pro Leu Pro Leu Leu Phe Val Leu Ile Pro Gln Ile Leu Gly Val Asn 245 250 255 Leu Gly Leu Trp Ala Ile Ala Ala Lys Glu Lys Arg Val Gly Leu Lys 260 265 270 Val Lys Ser Leu Arg Leu Leu Ile Arg Asp Leu Pro Ala Ile Phe Lys 275 280 285 Leu Arg Arg Ser Thr Gln Glu Leu Ala Glu Leu Thr Pro Ser Gln Tyr 290 295 300 Leu Ala Lys Met Glu Trp Arg Leu Asp Asn Pro Asn Leu Gly Asn Ile 305 310 315 320 Gly Ser Asn Lys Ile Val Ala Thr Gly Tyr Lys Thr Tyr Tyr Lys Leu 325 330 335 Cys Met Ser Ile Leu Lys Leu Leu Ala 340 345 <210> 169 <211> 757 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(727) <223> RXA01585 <400> 169 tgcagactgc tgcgccccgt tccatcagca aggtggagcg caaggtgctg accgctgtcg 60 ctactgatga ggtgcagtcg caggaagctc tagaaaagta gtg gtt gag act ctt 115 Val Val Glu Thr Leu 1 5 tct atc acc tca ggt gcg gct ggc ctg cag gcg ctt gtt gcg cgt gcg 163 Ser Ile Thr Ser Gly Ala Ala Gly Leu Gln Ala Leu Val Ala Arg Ala 10 15 20 gtt ggt ttg gat gag ttg gcg agc gcg cgt ttc cgc cag ctc acg cca 211 Val Gly Leu Asp Glu Leu Ala Ser Ala Arg Phe Arg Gln Leu Thr Pro 25 30 35 gag gtc gtt gat gtt ttt gtc acc act ccg ttc aac gtg acg gcg tcg 259 Glu Val Val Asp Val Phe Val Thr Thr Pro Phe Asn Val Thr Ala Ser 40 45 50 cgc cgg gta ttt ggt gtg gcg ggt cgc gat ggc gct gca gtt ggc gcg 307 Arg Arg Val Phe Gly Val Ala Gly Arg Asp Gly Ala Ala Val Gly Ala 55 60 65 aag gat ttg ctg cag gca ctc agc gag ggc cgg gaa gac gta ggc acc 355 Lys Asp Leu Leu Gln Ala Leu Ser Glu Gly Arg Glu Asp Val Gly Thr 70 75 80 85 tcc cgc gac gcc agc tgg ccg ggc tca ttg ccg cca gcc acg ggc ttt 403 Ser Arg Asp Ala Ser Trp Pro Gly Ser Leu Pro Pro Ala Thr Gly Phe 90 95 100 acg ctt gtc gac gaa ctc ccc acc cac gtg gtg cgc act ttg gct gat 451 Thr Leu Val Asp Glu Leu Pro Thr His Val Val Arg Thr Leu Ala Asp 105 110 115 cag ggt cag gca ttg gct cgc cag ttc tcc ggc ccg ctt ggc cct ccg 499 Gln Gly Gln Ala Leu Ala Arg Gln Phe Ser Gly Pro Leu Gly Pro Pro 120 125 130 gct tcg ttg atg gat cag gaa gtt att tca gca gaa ggc aat ggc aag 547 Ala Ser Leu Met Asp Gln Glu Val Ile Ser Ala Glu Gly Asn Gly Lys 135 140 145 aag gcc gga atc ccg atg cgc acg gta ttt acc tgc act tcg ctt ggt 595 Lys Ala Gly Ile Pro Met Arg Thr Val Phe Thr Cys Thr Ser Leu Gly 150 155 160 165 ttg atc cca ggt ttt gag gca gcc aat gat gtg ccg agg cac ctg cgg 643 Leu Ile Pro Gly Phe Glu Ala Ala Asn Asp Val Pro Arg His Leu Arg 170 175 180 gta tcg gtg aat ggt cgt tgg acc cgc gtt gat gct ccc tat ggc agt 691 Val Ser Val Asn Gly Arg Trp Thr Arg Val Asp Ala Pro Tyr Gly Ser 185 190 195 gtt tat cac tcg tca ggt ttg ggt ctg agc gtt ttc taaagcaaga 737 Val Tyr His Ser Ser Gly Leu Gly Leu Ser Val Phe 200 205 cccagcctgc aagggccgca 757 <210> 170 <211> 209 <212> PRT <213> Corynebacterium glutamicum <400> 170 Val Val Glu Thr Leu Ser Ile Thr Ser Gly Ala Ala Gly Leu Gln Ala 1 5 10 15 Leu Val Ala Arg Ala Val Gly Leu Asp Glu Leu Ala Ser Ala Arg Phe 20 25 30 Arg Gln Leu Thr Pro Glu Val Val Asp Val Phe Val Thr Thr Pro Phe 35 40 45 Asn Val Thr Ala Ser Arg Arg Val Phe Gly Val Ala Gly Arg Asp Gly 50 55 60 Ala Ala Val Gly Ala Lys Asp Leu Leu Gln Ala Leu Ser Glu Gly Arg 65 70 75 80 Glu Asp Val Gly Thr Ser Arg Asp Ala Ser Trp Pro Gly Ser Leu Pro 85 90 95 Pro Ala Thr Gly Phe Thr Leu Val Asp Glu Leu Pro Thr His Val Val 100 105 110 Arg Thr Leu Ala Asp Gln Gly Gln Ala Leu Ala Arg Gln Phe Ser Gly 115 120 125 Pro Leu Gly Pro Pro Ala Ser Leu Met Asp Gln Glu Val Ile Ser Ala 130 135 140 Glu Gly Asn Gly Lys Lys Ala Gly Ile Pro Met Arg Thr Val Phe Thr 145 150 155 160 Cys Thr Ser Leu Gly Leu Ile Pro Gly Phe Glu Ala Ala Asn Asp Val 165 170 175 Pro Arg His Leu Arg Val Ser Val Asn Gly Arg Trp Thr Arg Val Asp 180 185 190 Ala Pro Tyr Gly Ser Val Tyr His Ser Ser Gly Leu Gly Leu Ser Val 195 200 205 Phe <210> 171 <211> 6592 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(6562) <223> RXA01590 <400> 171 tccgcatgtc cattagtgat atgacaaaag aataaagaaa agggaggact ttagtatgtc 60 caaaacttta tttcgacacg cttttgaacg gtcgcttgag atg gcg cgc tca gag 115 Met Ala Arg Ser Glu 1 5 tgg ggt caa aaa gat cac tgg ggc aaa gct cca ctg ggt gat cac gat 163 Trp Gly Gln Lys Asp His Trp Gly Lys Ala Pro Leu Gly Asp His Asp 10 15 20 gct gtg cgt atc tat agg caa gca gaa gcc ttg atg aaa cag cgc gca 211 Ala Val Arg Ile Tyr Arg Gln Ala Glu Ala Leu Met Lys Gln Arg Ala 25 30 35 gca aac aat aag ggc tta gac ctc aat gat gaa gcg acc tat ggc gcc 259 Ala Asn Asn Lys Gly Leu Asp Leu Asn Asp Glu Ala Thr Tyr Gly Ala 40 45 50 atc atg ttt gcg tct ttc gat gat gcc ttc gcc gct gat gcc gaa gct 307 Ile Met Phe Ala Ser Phe Asp Asp Ala Phe Ala Ala Asp Ala Glu Ala 55 60 65 cat ggc tgt gta cac cga cca cag ttc gcg aag gta act agg cga aat 355 His Gly Cys Val His Arg Pro Gln Phe Ala Lys Val Thr Arg Arg Asn 70 75 80 85 att ctt aat tca ccg caa tac acg gcg att aag tca tct tat gac gcg 403 Ile Leu Asn Ser Pro Gln Tyr Thr Ala Ile Lys Ser Ser Tyr Asp Ala 90 95 100 ctg gtg cag cag gat ctc gtg gcc caa cag cag cag gca caa gcg cta 451 Leu Val Gln Gln Asp Leu Val Ala Gln Gln Gln Gln Ala Gln Ala Leu 105 110 115 cag caa gct gct tat gag caa gag cag gca gct att ttc cag gca cgt 499 Gln Gln Ala Ala Tyr Glu Gln Glu Gln Ala Ala Ile Phe Gln Ala Arg 120 125 130 gat caa gca aca ttc cag gct gaa caa acg ctc gcg caa gag tcc gtt 547 Asp Gln Ala Thr Phe Gln Ala Glu Gln Thr Leu Ala Gln Glu Ser Val 135 140 145 cgc caa tca gag ggt gtg ggt tta cct gtc att gat ccg atg gag agc 595 Arg Gln Ser Glu Gly Val Gly Leu Pro Val Ile Asp Pro Met Glu Ser 150 155 160 165 tat ttc cgg gag tac gcc ttc tat gaa ggt gtc gag atg ttt ggt acc 643 Tyr Phe Arg Glu Tyr Ala Phe Tyr Glu Gly Val Glu Met Phe Gly Thr 170 175 180 tgg ggt acg cac gtt gat gct ggt gtg tcg cag ttt agc acc tct gat 691 Trp Gly Thr His Val Asp Ala Gly Val Ser Gln Phe Ser Thr Ser Asp 185 190 195 ggc cgt gcg atc cga gcg ctt gtt gat gag cat ctc gca acc tat gaa 739 Gly Arg Ala Ile Arg Ala Leu Val Asp Glu His Leu Ala Thr Tyr Glu 200 205 210 cca gta gag cag cgg ggg agt act cag gca ttc ttc gcc tct gtc aat 787 Pro Val Glu Gln Arg Gly Ser Thr Gln Ala Phe Phe Ala Ser Val Asn 215 220 225 gct gcc ttt gct gag gtg gca cct cac gca gca ccc atg ttt agt gcg 835 Ala Ala Phe Ala Glu Val Ala Pro His Ala Ala Pro Met Phe Ser Ala 230 235 240 245 att gct cgc gag ggt gag ggt tca aag ggg tac cag gcg ctg cgt cac 883 Ile Ala Arg Glu Gly Glu Gly Ser Lys Gly Tyr Gln Ala Leu Arg His 250 255 260 cgt ttc gac aag atg gtc ggc act gca att gga cct aat ggt ttg cct 931 Arg Phe Asp Lys Met Val Gly Thr Ala Ile Gly Pro Asn Gly Leu Pro 265 270 275 gag gga cct gat ctg ggt ggt cgt cgt tta cct att tcg cct tat gat 979 Glu Gly Pro Asp Leu Gly Gly Arg Arg Leu Pro Ile Ser Pro Tyr Asp 280 285 290 cca cgc tgg tca gac cgc gaa gta gtc cgt gtg cac ggt acc aag ctg 1027 Pro Arg Trp Ser Asp Arg Glu Val Val Arg Val His Gly Thr Lys Leu 295 300 305 cta tca ctg tcc gaa gag agt gtt ggc atg atc agg gac ctt gat cta 1075 Leu Ser Leu Ser Glu Glu Ser Val Gly Met Ile Arg Asp Leu Asp Leu 310 315 320 325 gca acg atc cac cta caa gat aat gat gtt tac gag ggc act cat cga 1123 Ala Thr Ile His Leu Gln Asp Asn Asp Val Tyr Glu Gly Thr His Arg 330 335 340 gaa gac gac act aaa ggc ggt gtg cga ccg ttg act caa tgg gtc aat 1171 Glu Asp Asp Thr Lys Gly Gly Val Arg Pro Leu Thr Gln Trp Val Asn 345 350 355 ggt gaa gct att gcc tgg cgc act atc acc gag aat gac cag atg cga 1219 Gly Glu Ala Ile Ala Trp Arg Thr Ile Thr Glu Asn Asp Gln Met Arg 360 365 370 ctg ccc aat att ggt cag ttt atg acg gct aaa gaa tac cgt gcc gca 1267 Leu Pro Asn Ile Gly Gln Phe Met Thr Ala Lys Glu Tyr Arg Ala Ala 375 380 385 gcg tca tgg ctg cgt gct gga ctc att gat acc gca gat gtt gcg agt 1315 Ala Ser Trp Leu Arg Ala Gly Leu Ile Asp Thr Ala Asp Val Ala Ser 390 395 400 405 cag aaa att gac ccc aac aag gtc atg tct gat gag ggt atc gcg cgc 1363 Gln Lys Ile Asp Pro Asn Lys Val Met Ser Asp Glu Gly Ile Ala Arg 410 415 420 tcg gaa gct att ttg acg tat ctg tcg gat gag ggt gtg gat ttt agg 1411 Ser Glu Ala Ile Leu Thr Tyr Leu Ser Asp Glu Gly Val Asp Phe Arg 425 430 435 atc gag cca gat cgt gag ccg gga cag ctt aaa gtg cgt att gag ggc 1459 Ile Glu Pro Asp Arg Glu Pro Gly Gln Leu Lys Val Arg Ile Glu Gly 440 445 450 acc cgt att gat att cgt ctc act gat act cgc gcc aat gaa cag tgg 1507 Thr Arg Ile Asp Ile Arg Leu Thr Asp Thr Arg Ala Asn Glu Gln Trp 455 460 465 gtg ggt cgt gtc tat gat tct ggc act gtg att aag tat tcc gcc gaa 1555 Val Gly Arg Val Tyr Asp Ser Gly Thr Val Ile Lys Tyr Ser Ala Glu 470 475 480 485 caa aca gcg gaa gaa cgt cta cga gct cgt gag cgc atg gag aac ggt 1603 Gln Thr Ala Glu Glu Arg Leu Arg Ala Arg Glu Arg Met Glu Asn Gly 490 495 500 gat gga acg tgg aca ccg gct act gat tat gaa cca agc cca act gaa 1651 Asp Gly Thr Trp Thr Pro Ala Thr Asp Tyr Glu Pro Ser Pro Thr Glu 505 510 515 gtt gtc gat ctc gtg aaa ttt gct ctc ggt cga gag gtt gag cga cag 1699 Val Val Asp Leu Val Lys Phe Ala Leu Gly Arg Glu Val Glu Arg Gln 520 525 530 gat ggc aaa ggt ctt gtt ggt gtg cct aat gct cga cac cca cgt gct 1747 Asp Gly Lys Gly Leu Val Gly Val Pro Asn Ala Arg His Pro Arg Ala 535 540 545 tta gag cag gca cag gat gca tat ttc act aag aat cgt tcc gca ttc 1795 Leu Glu Gln Ala Gln Asp Ala Tyr Phe Thr Lys Asn Arg Ser Ala Phe 550 555 560 565 atg gtg cgt gaa ggg ctc tcg atc gtt cag gat gca cgt gat cga agt 1843 Met Val Arg Glu Gly Leu Ser Ile Val Gln Asp Ala Arg Asp Arg Ser 570 575 580 gct ggt cct gga aag tgg ttt gat aat gaa gcg aaa gca tcg gag tgg 1891 Ala Gly Pro Gly Lys Trp Phe Asp Asn Glu Ala Lys Ala Ser Glu Trp 585 590 595 ctt ggt aac aat atc gcc ctt act cgt gcg cgt gtg gcc gaa gag ctc 1939 Leu Gly Asn Asn Ile Ala Leu Thr Arg Ala Arg Val Ala Glu Glu Leu 600 605 610 ggc gtt gaa gaa ctg att gcg ctt tct gca cag tac gcc gat gat cct 1987 Gly Val Glu Glu Leu Ile Ala Leu Ser Ala Gln Tyr Ala Asp Asp Pro 615 620 625 gac ttc atg ccg gct ttt gct ggt gag gat gag ctc atg gcg ata aag 2035 Asp Phe Met Pro Ala Phe Ala Gly Glu Asp Glu Leu Met Ala Ile Lys 630 635 640 645 cag gac tat tgg gcg atg ctg cga ggt gag gaa acc gat ctg ctt aac 2083 Gln Asp Tyr Trp Ala Met Leu Arg Gly Glu Glu Thr Asp Leu Leu Asn 650 655 660 cct ggg gtt aac cgc gat gat tat atg gct gct atc cgc gat ggt gat 2131 Pro Gly Val Asn Arg Asp Asp Tyr Met Ala Ala Ile Arg Asp Gly Asp 665 670 675 cat gag cag att gct gcg atg acc tca gca atg aat gct gtg acc gtg 2179 His Glu Gln Ile Ala Ala Met Thr Ser Ala Met Asn Ala Val Thr Val 680 685 690 gag gat cgt gtg cgt cag cac gcg gcc ctt gtt ctt gat gat tat gtc 2227 Glu Asp Arg Val Arg Gln His Ala Ala Leu Val Leu Asp Asp Tyr Val 695 700 705 ggc acg gtg gag cct gat cct gtt acc ggc ttg cgt ttt aat ccg gtg 2275 Gly Thr Val Glu Pro Asp Pro Val Thr Gly Leu Arg Phe Asn Pro Val 710 715 720 725 aca gtt gct cag cac atg ccg agt gct aaa tcc ctg tgg tca aac cat 2323 Thr Val Ala Gln His Met Pro Ser Ala Lys Ser Leu Trp Ser Asn His 730 735 740 gac gat att att gcc gcg ttg cga gcg act tcg att act ggc gat gaa 2371 Asp Asp Ile Ile Ala Ala Leu Arg Ala Thr Ser Ile Thr Gly Asp Glu 745 750 755 ctg cgc ggt gac gaa ttc tat aac gat gtt att aat caa cag ttg ctc 2419 Leu Arg Gly Asp Glu Phe Tyr Asn Asp Val Ile Asn Gln Gln Leu Leu 760 765 770 aaa ttt aat cct gag acc gcg cag aaa atg gtt aat aac cct gat ctt 2467 Lys Phe Asn Pro Glu Thr Ala Gln Lys Met Val Asn Asn Pro Asp Leu 775 780 785 gac ccg cag ttg gct cga ttt ggc act gtc att gcc gag act att tcc 2515 Asp Pro Gln Leu Ala Arg Phe Gly Thr Val Ile Ala Glu Thr Ile Ser 790 795 800 805 cgc aat ggt gct gat gtg gtc gat att gct gtt gac gat aac ggt gtg 2563 Arg Asn Gly Ala Asp Val Val Asp Ile Ala Val Asp Asp Asn Gly Val 810 815 820 gtg cgg tgg acc gca cag cga cgt gtt ggt gcg aag gat agt cgt gca 2611 Val Arg Trp Thr Ala Gln Arg Arg Val Gly Ala Lys Asp Ser Arg Ala 825 830 835 gta gat agt aag ggg cag gtt cgc ggt gaa cgc acc cgt cat gtg cag 2659 Val Asp Ser Lys Gly Gln Val Arg Gly Glu Arg Thr Arg His Val Gln 840 845 850 ggt gag ata ggt cag att ttt act cgc ggt gag cat ggt gaa att gtc 2707 Gly Glu Ile Gly Gln Ile Phe Thr Arg Gly Glu His Gly Glu Ile Val 855 860 865 acc aaa ttt aat ggt ggc gag aac tat atg ttt gcc cct ggc tac acc 2755 Thr Lys Phe Asn Gly Gly Glu Asn Tyr Met Phe Ala Pro Gly Tyr Thr 870 875 880 885 gcg tct gtg gta cca caa aag cct ggt gag aca aag agt tta gaa gag 2803 Ala Ser Val Val Pro Gln Lys Pro Gly Glu Thr Lys Ser Leu Glu Glu 890 895 900 cgt acc aag ctc aaa ggc tat gag cag gtg atg tca gag gcg ttg gtg 2851 Arg Thr Lys Leu Lys Gly Tyr Glu Gln Val Met Ser Glu Ala Leu Val 905 910 915 tac cgt gtg cga gaa gat ttg atg ttc act gag cga tcc cga gtg ggt 2899 Tyr Arg Val Arg Glu Asp Leu Met Phe Thr Glu Arg Ser Arg Val Gly 920 925 930 gct aca acc agc atc aac agt gca tat aag cga ctg tat gac aat cgc 2947 Ala Thr Thr Ser Ile Asn Ser Ala Tyr Lys Arg Leu Tyr Asp Asn Arg 935 940 945 ttc cct gtg gac ttc ttc gag cgc agc gcc gaa gaa ggt ttg agc gat 2995 Phe Pro Val Asp Phe Phe Glu Arg Ser Ala Glu Glu Gly Leu Ser Asp 950 955 960 965 gag tgg cgt gct gcg ttg ctt gag act gcg agt ttg cgt gtg cgc tac 3043 Glu Trp Arg Ala Ala Leu Leu Glu Thr Ala Ser Leu Arg Val Arg Tyr 970 975 980 gac aac tct att cgt gat ggt gcg aat gtg atg gag gat att cga gca 3091 Asp Asn Ser Ile Arg Asp Gly Ala Asn Val Met Glu Asp Ile Arg Ala 985 990 995 cag cag cgt ggt ttt gat gcg cgt aat gat aac tcc cgt gat gcg ctg 3139 Gln Gln Arg Gly Phe Asp Ala Arg Asn Asp Asn Ser Arg Asp Ala Leu 1000 1005 1010 gtg ctt acc ggt ggg cgt aac att tct gta ctt gat gtt gat gcg ggt 3187 Val Leu Thr Gly Gly Arg Asn Ile Ser Val Leu Asp Val Asp Ala Gly 1015 1020 1025 aaa ggt ttc ttt gat ccc atg atg act ggt atg gcg gcg aac cag ggt 3235 Lys Gly Phe Phe Asp Pro Met Met Thr Gly Met Ala Ala Asn Gln Gly 1030 1035 1040 1045 tct gtt cgc tat ttg ttg cct tct gcg aag gtg ggc gct gat ggc atg 3283 Ser Val Arg Tyr Leu Leu Pro Ser Ala Lys Val Gly Ala Asp Gly Met 1050 1055 1060 att acc cct ggt gat ccg gct gat cga gta cct gtt gca gcg cat cca 3331 Ile Thr Pro Gly Asp Pro Ala Asp Arg Val Pro Val Ala Ala His Pro 1065 1070 1075 gaa tca tgg gcg atg ggc ttt gac cca cat gac cgt cag aac atg act 3379 Glu Ser Trp Ala Met Gly Phe Asp Pro His Asp Arg Gln Asn Met Thr 1080 1085 1090 ttc tcg aac atc atg cag gct agc gct gtg act ggt ggt gca cgc act 3427 Phe Ser Asn Ile Met Gln Ala Ser Ala Val Thr Gly Gly Ala Arg Thr 1095 1100 1105 gcg atg ata cag ctg ggc ggt tgg aac ttt gaa gat ggc att att gtc 3475 Ala Met Ile Gln Leu Gly Gly Trp Asn Phe Glu Asp Gly Ile Ile Val 1110 1115 1120 1125 tct gcc gat ttt gcg aat acc cat gtt att cgc gat acg gaa gat gag 3523 Ser Ala Asp Phe Ala Asn Thr His Val Ile Arg Asp Thr Glu Asp Glu 1130 1135 1140 atg cgc ccc ttg gtt gcc ggc gat aag ctg tct gat ttt cac ggt aat 3571 Met Arg Pro Leu Val Ala Gly Asp Lys Leu Ser Asp Phe His Gly Asn 1145 1150 1155 aag ggt gtg atc gct ctt gtt gtt gat cca gcg atg agt gat gct gat 3619 Lys Gly Val Ile Ala Leu Val Val Asp Pro Ala Met Ser Asp Ala Asp 1160 1165 1170 gca cgt gca gca ggg ctg gaa tca gag gtg gcg ttt ttc cga gac aac 3667 Ala Arg Ala Ala Gly Leu Glu Ser Glu Val Ala Phe Phe Arg Asp Asn 1175 1180 1185 cct gat cta gag gtt gtc atg agt ccg ttt tct gcc att tct cgt ttt 3715 Pro Asp Leu Glu Val Val Met Ser Pro Phe Ser Ala Ile Ser Arg Phe 1190 1195 1200 1205 aat ggt ggc acg gca cgt gag ctc atg aac aac ccg cag gat gtg gtg 3763 Asn Gly Gly Thr Ala Arg Glu Leu Met Asn Asn Pro Gln Asp Val Val 1210 1215 1220 ttc agg aat aat gat ggt tct act cgt gtt caa cca ggt gcc tct ggt 3811 Phe Arg Asn Asn Asp Gly Ser Thr Arg Val Gln Pro Gly Ala Ser Gly 1225 1230 1235 gat ctc aac ttc atc gtc acg cat atg gct gtt gat gcg aaa acc aat 3859 Asp Leu Asn Phe Ile Val Thr His Met Ala Val Asp Ala Lys Thr Asn 1240 1245 1250 gtc tat gat gaa gaa gct gtt cgt gag ggc caa gga cgt aaa gcg tct 3907 Val Tyr Asp Glu Glu Ala Val Arg Glu Gly Gln Gly Arg Lys Ala Ser 1255 1260 1265 tct cag ctg gcg tgg gtg ctc caa gcc cag gaa tgt cat gag att atg 3955 Ser Gln Leu Ala Trp Val Leu Gln Ala Gln Glu Cys His Glu Ile Met 1270 1275 1280 1285 gag cac ttt tat ggc aac aac gtc tct gca ttg gct aac ttc cag gaa 4003 Glu His Phe Tyr Gly Asn Asn Val Ser Ala Leu Ala Asn Phe Gln Glu 1290 1295 1300 tat ctt cgc gtc acg ggg ctt gat gtc acc ccg tat ggt gag ttg cgc 4051 Tyr Leu Arg Val Thr Gly Leu Asp Val Thr Pro Tyr Gly Glu Leu Arg 1305 1310 1315 gag ggg ttc agc gag tcc aat gag cag cgc aat atc atc gag atg cca 4099 Glu Gly Phe Ser Glu Ser Asn Glu Gln Arg Asn Ile Ile Glu Met Pro 1320 1325 1330 agc att tac gat gag aac ggt gag ctg aat aat cgt gtt aat cgt gca 4147 Ser Ile Tyr Asp Glu Asn Gly Glu Leu Asn Asn Arg Val Asn Arg Ala 1335 1340 1345 cag gtg cgc gaa gct ttt gtt gag cag atc agt cgc gct ggt ggt gtt 4195 Gln Val Arg Glu Ala Phe Val Glu Gln Ile Ser Arg Ala Gly Gly Val 1350 1355 1360 1365 atg gag att cct ttc cag tta cag ttg cgc aat ggt gca cag cta gaa 4243 Met Glu Ile Pro Phe Gln Leu Gln Leu Arg Asn Gly Ala Gln Leu Glu 1370 1375 1380 gag tca cct aat aat cca gac atg tat cag ttg cca cta ctg agc ccg 4291 Glu Ser Pro Asn Asn Pro Asp Met Tyr Gln Leu Pro Leu Leu Ser Pro 1385 1390 1395 cat ttg cgc agt gat gag gat tta gcg gac ggt agt acc tct cga cat 4339 His Leu Arg Ser Asp Glu Asp Leu Ala Asp Gly Ser Thr Ser Arg His 1400 1405 1410 gag tac acc acg cgg tat atg gct att ttt gat acg tgc tac aag ctg 4387 Glu Tyr Thr Thr Arg Tyr Met Ala Ile Phe Asp Thr Cys Tyr Lys Leu 1415 1420 1425 gca gaa gag caa gcc aag att gac gca ttg cgc cag gag gaa gcg cag 4435 Ala Glu Glu Gln Ala Lys Ile Asp Ala Leu Arg Gln Glu Glu Ala Gln 1430 1435 1440 1445 cac ggc acg ttg cct cgt gct gcg gaa aag cga ctg agc gag tca cag 4483 His Gly Thr Leu Pro Arg Ala Ala Glu Lys Arg Leu Ser Glu Ser Gln 1450 1455 1460 aag ttt gtt gat caa gca cag aaa aag gtg cag gca agc ttt gat gga 4531 Lys Phe Val Asp Gln Ala Gln Lys Lys Val Gln Ala Ser Phe Asp Gly 1465 1470 1475 att gct aat gat att gtc gcc agc cgg atc gag acc aag aac aat gtg 4579 Ile Ala Asn Asp Ile Val Ala Ser Arg Ile Glu Thr Lys Asn Asn Val 1480 1485 1490 ttc aag gac ggc ttt atg tcg gcg cga cag tca cac tcc gct act gct 4627 Phe Lys Asp Gly Phe Met Ser Ala Arg Gln Ser His Ser Ala Thr Ala 1495 1500 1505 gtg tgg aca ggt gat cca cgc ctg tca gtt gat gaa gta gcc atg aac 4675 Val Trp Thr Gly Asp Pro Arg Leu Ser Val Asp Glu Val Ala Met Asn 1510 1515 1520 1525 tct tcg atg gca cgt gaa ctc ggc gtt ctc gat aac ggt tat gca atg 4723 Ser Ser Met Ala Arg Glu Leu Gly Val Leu Asp Asn Gly Tyr Ala Met 1530 1535 1540 gtg tgg cgt gat ccg gtg atc cgc gat ggt ggt gtg cgc tat ttg cgt 4771 Val Trp Arg Asp Pro Val Ile Arg Asp Gly Gly Val Arg Tyr Leu Arg 1545 1550 1555 gtg gtt att aat gat gat ctg cac ggt gtg gca gtc aac cct gtg tcg 4819 Val Val Ile Asn Asp Asp Leu His Gly Val Ala Val Asn Pro Val Ser 1560 1565 1570 gtg aag agc ttt gac ggt gac ttc gat ggt gac tct gta ggt ctg gtc 4867 Val Lys Ser Phe Asp Gly Asp Phe Asp Gly Asp Ser Val Gly Leu Val 1575 1580 1585 ggc aat ctg ccg aaa aag gcg cat gag gag gca ttg tcc agg ctc aca 4915 Gly Asn Leu Pro Lys Lys Ala His Glu Glu Ala Leu Ser Arg Leu Thr 1590 1595 1600 1605 gtt gag gca aac atg ctt gat ctt ggt gat ggt aag cgt atg gag gac 4963 Val Glu Ala Asn Met Leu Asp Leu Gly Asp Gly Lys Arg Met Glu Asp 1610 1615 1620 ggc act atg ttt tat ggg cta act ctg cat gac agc ctc gat gta cag 5011 Gly Thr Met Phe Tyr Gly Leu Thr Leu His Asp Ser Leu Asp Val Gln 1625 1630 1635 gta gcg cag cac cat gat ccg gca atg gcc gag aac atg aag gtt att 5059 Val Ala Gln His His Asp Pro Ala Met Ala Glu Asn Met Lys Val Ile 1640 1645 1650 gtc tct gag ctt aac cgc tac cag cgt gaa tac gag gcc ggc gag att 5107 Val Ser Glu Leu Asn Arg Tyr Gln Arg Glu Tyr Glu Ala Gly Glu Ile 1655 1660 1665 agc cgc gaa gaa ttg cta gag gtc aac cgt gca cac atg gat gat ctc 5155 Ser Arg Glu Glu Leu Leu Glu Val Asn Arg Ala His Met Asp Asp Leu 1670 1675 1680 1685 aat gag cac tat gca cag gct ttt gcc aac cgc gat ggt ttg gtg acc 5203 Asn Glu His Tyr Ala Gln Ala Phe Ala Asn Arg Asp Gly Leu Val Thr 1690 1695 1700 ttg cgt ttt gac ggt atg gaa aac cat atg gct tct gtt gcg cag tgc 5251 Leu Arg Phe Asp Gly Met Glu Asn His Met Ala Ser Val Ala Gln Cys 1705 1710 1715 ttc gag acg ggt gcg aaa ggt tcg cct ggc aag ctg aag gaa tat gcc 5299 Phe Glu Thr Gly Ala Lys Gly Ser Pro Gly Lys Leu Lys Glu Tyr Ala 1720 1725 1730 acc tat atc ggc gct gat ccg gcg cag ggt ttt aaa gac gta ggt caa 5347 Thr Tyr Ile Gly Ala Asp Pro Ala Gln Gly Phe Lys Asp Val Gly Gln 1735 1740 1745 cca acg cca gaa gcg ctg cgt agc cac tat gag ggt tcg cag aag gcg 5395 Pro Thr Pro Glu Ala Leu Arg Ser His Tyr Glu Gly Ser Gln Lys Ala 1750 1755 1760 1765 act gca att aag gtg ctc ttt acc ggt gtg gct ggt aaa aaa gag cag 5443 Thr Ala Ile Lys Val Leu Phe Thr Gly Val Ala Gly Lys Lys Glu Gln 1770 1775 1780 gaa atg gtg gca ttg tgc cgc aat ctt ggt ctg acc aag gaa gct atg 5491 Glu Met Val Ala Leu Cys Arg Asn Leu Gly Leu Thr Lys Glu Ala Met 1785 1790 1795 gct gca tca gca ccg gca cag cag tcg att ctg cag gcg aag cac gac 5539 Ala Ala Ser Ala Pro Ala Gln Gln Ser Ile Leu Gln Ala Lys His Asp 1800 1805 1810 ccg att gac gcg ctc tat cgt gca gaa act ctt atg gga cca gta ggt 5587 Pro Ile Asp Ala Leu Tyr Arg Ala Glu Thr Leu Met Gly Pro Val Gly 1815 1820 1825 gat ctc tac caa ggt cgc aag atg cgt cgt ggt gag aat gag caa ggt 5635 Asp Leu Tyr Gln Gly Arg Lys Met Arg Arg Gly Glu Asn Glu Gln Gly 1830 1835 1840 1845 cgc tat gag tgg gaa gtc gtt agg gac gag aac cac cag cct atc cag 5683 Arg Tyr Glu Trp Glu Val Val Arg Asp Glu Asn His Gln Pro Ile Gln 1850 1855 1860 gcc acc aag gat gaa tgg gta cag cag tac atg gag atg tac gcc gat 5731 Ala Thr Lys Asp Glu Trp Val Gln Gln Tyr Met Glu Met Tyr Ala Asp 1865 1870 1875 gac aag ggt atg ggt gtc tcg gtt ggc gtt gac cag gtg gag aag atc 5779 Asp Lys Gly Met Gly Val Ser Val Gly Val Asp Gln Val Glu Lys Ile 1880 1885 1890 gcg gaa gaa ttc tct gat gag cag ggt tat atg cgt gtg ctt agc cat 5827 Ala Glu Glu Phe Ser Asp Glu Gln Gly Tyr Met Arg Val Leu Ser His 1895 1900 1905 gat gag cta ccc act gag att aag cca cta gca ctt gat cag ctt gcc 5875 Asp Glu Leu Pro Thr Glu Ile Lys Pro Leu Ala Leu Asp Gln Leu Ala 1910 1915 1920 1925 tat ggc gat aag aag aac cgc ttt gat ttg ttg tgc gag atg gca aag 5923 Tyr Gly Asp Lys Lys Asn Arg Phe Asp Leu Leu Cys Glu Met Ala Lys 1930 1935 1940 cag cag gtc aac atc tac gac ggt gat gct tat gac ttt gcc cct cgt 5971 Gln Gln Val Asn Ile Tyr Asp Gly Asp Ala Tyr Asp Phe Ala Pro Arg 1945 1950 1955 gtg gtg cgc gcc aat atg aag gca atg gag gat gca gcg cgt ttt ggt 6019 Val Val Arg Ala Asn Met Lys Ala Met Glu Asp Ala Ala Arg Phe Gly 1960 1965 1970 atc cct gat gtg gag att cag tcg att tct gca cag cag tca ttg gcg 6067 Ile Pro Asp Val Glu Ile Gln Ser Ile Ser Ala Gln Gln Ser Leu Ala 1975 1980 1985 agc ttt gag cga gtc cca caa cgt tct ggt ttc cgt att gag cgt cgt 6115 Ser Phe Glu Arg Val Pro Gln Arg Ser Gly Phe Arg Ile Glu Arg Arg 1990 1995 2000 2005 gtg ccg gca gaa gta ggt aca ggg att gct gca cca gca ccg tta cct 6163 Val Pro Ala Glu Val Gly Thr Gly Ile Ala Ala Pro Ala Pro Leu Pro 2010 2015 2020 gat gca ggt gta cag ggg aat tat gtt cag cag cag gtg cct gcg acc 6211 Asp Ala Gly Val Gln Gly Asn Tyr Val Gln Gln Gln Val Pro Ala Thr 2025 2030 2035 ccg cca gtt atg cct gtc aca cct ccg gca cag caa cct gtt tcg cct 6259 Pro Pro Val Met Pro Val Thr Pro Pro Ala Gln Gln Pro Val Ser Pro 2040 2045 2050 gct cag acg gac ttc cgg ggc gtt ggt cag cca ctc gac cag ggc gga 6307 Ala Gln Thr Asp Phe Arg Gly Val Gly Gln Pro Leu Asp Gln Gly Gly 2055 2060 2065 aaa atc ggg aat tat gga cat cag gga cct gca atg ggg gcg caa cag 6355 Lys Ile Gly Asn Tyr Gly His Gln Gly Pro Ala Met Gly Ala Gln Gln 2070 2075 2080 2085 cca gtt gtg cct cag cag cag aat att ccg cct gtg cat aat ccg gta 6403 Pro Val Val Pro Gln Gln Gln Asn Ile Pro Pro Val His Asn Pro Val 2090 2095 2100 cca cag aat tct gtt ccg cct act ccg gtt gtg ccg aag cca ggt aca 6451 Pro Gln Asn Ser Val Pro Pro Thr Pro Val Val Pro Lys Pro Gly Thr 2105 2110 2115 gga aac ccg ttt act cat ggt ggt gcg aac aat cag ttt atg ggt cga 6499 Gly Asn Pro Phe Thr His Gly Gly Ala Asn Asn Gln Phe Met Gly Arg 2120 2125 2130 ttt gat aca agc cgt tac aac caa cag gaa cca cca caa cga cag gat 6547 Phe Asp Thr Ser Arg Tyr Asn Gln Gln Glu Pro Pro Gln Arg Gln Asp 2135 2140 2145 ggc ggg ttt gag ctc taaataatgg cagtagattt cagcagaaaa 6592 Gly Gly Phe Glu Leu 2150 <210> 172 <211> 2154 <212> PRT <213> Corynebacterium glutamicum <400> 172 Met Ala Arg Ser Glu Trp Gly Gln Lys Asp His Trp Gly Lys Ala Pro 1 5 10 15 Leu Gly Asp His Asp Ala Val Arg Ile Tyr Arg Gln Ala Glu Ala Leu 20 25 30 Met Lys Gln Arg Ala Ala Asn Asn Lys Gly Leu Asp Leu Asn Asp Glu 35 40 45 Ala Thr Tyr Gly Ala Ile Met Phe Ala Ser Phe Asp Asp Ala Phe Ala 50 55 60 Ala Asp Ala Glu Ala His Gly Cys Val His Arg Pro Gln Phe Ala Lys 65 70 75 80 Val Thr Arg Arg Asn Ile Leu Asn Ser Pro Gln Tyr Thr Ala Ile Lys 85 90 95 Ser Ser Tyr Asp Ala Leu Val Gln Gln Asp Leu Val Ala Gln Gln Gln 100 105 110 Gln Ala Gln Ala Leu Gln Gln Ala Ala Tyr Glu Gln Glu Gln Ala Ala 115 120 125 Ile Phe Gln Ala Arg Asp Gln Ala Thr Phe Gln Ala Glu Gln Thr Leu 130 135 140 Ala Gln Glu Ser Val Arg Gln Ser Glu Gly Val Gly Leu Pro Val Ile 145 150 155 160 Asp Pro Met Glu Ser Tyr Phe Arg Glu Tyr Ala Phe Tyr Glu Gly Val 165 170 175 Glu Met Phe Gly Thr Trp Gly Thr His Val Asp Ala Gly Val Ser Gln 180 185 190 Phe Ser Thr Ser Asp Gly Arg Ala Ile Arg Ala Leu Val Asp Glu His 195 200 205 Leu Ala Thr Tyr Glu Pro Val Glu Gln Arg Gly Ser Thr Gln Ala Phe 210 215 220 Phe Ala Ser Val Asn Ala Ala Phe Ala Glu Val Ala Pro His Ala Ala 225 230 235 240 Pro Met Phe Ser Ala Ile Ala Arg Glu Gly Glu Gly Ser Lys Gly Tyr 245 250 255 Gln Ala Leu Arg His Arg Phe Asp Lys Met Val Gly Thr Ala Ile Gly 260 265 270 Pro Asn Gly Leu Pro Glu Gly Pro Asp Leu Gly Gly Arg Arg Leu Pro 275 280 285 Ile Ser Pro Tyr Asp Pro Arg Trp Ser Asp Arg Glu Val Val Arg Val 290 295 300 His Gly Thr Lys Leu Leu Ser Leu Ser Glu Glu Ser Val Gly Met Ile 305 310 315 320 Arg Asp Leu Asp Leu Ala Thr Ile His Leu Gln Asp Asn Asp Val Tyr 325 330 335 Glu Gly Thr His Arg Glu Asp Asp Thr Lys Gly Gly Val Arg Pro Leu 340 345 350 Thr Gln Trp Val Asn Gly Glu Ala Ile Ala Trp Arg Thr Ile Thr Glu 355 360 365 Asn Asp Gln Met Arg Leu Pro Asn Ile Gly Gln Phe Met Thr Ala Lys 370 375 380 Glu Tyr Arg Ala Ala Ala Ser Trp Leu Arg Ala Gly Leu Ile Asp Thr 385 390 395 400 Ala Asp Val Ala Ser Gln Lys Ile Asp Pro Asn Lys Val Met Ser Asp 405 410 415 Glu Gly Ile Ala Arg Ser Glu Ala Ile Leu Thr Tyr Leu Ser Asp Glu 420 425 430 Gly Val Asp Phe Arg Ile Glu Pro Asp Arg Glu Pro Gly Gln Leu Lys 435 440 445 Val Arg Ile Glu Gly Thr Arg Ile Asp Ile Arg Leu Thr Asp Thr Arg 450 455 460 Ala Asn Glu Gln Trp Val Gly Arg Val Tyr Asp Ser Gly Thr Val Ile 465 470 475 480 Lys Tyr Ser Ala Glu Gln Thr Ala Glu Glu Arg Leu Arg Ala Arg Glu 485 490 495 Arg Met Glu Asn Gly Asp Gly Thr Trp Thr Pro Ala Thr Asp Tyr Glu 500 505 510 Pro Ser Pro Thr Glu Val Val Asp Leu Val Lys Phe Ala Leu Gly Arg 515 520 525 Glu Val Glu Arg Gln Asp Gly Lys Gly Leu Val Gly Val Pro Asn Ala 530 535 540 Arg His Pro Arg Ala Leu Glu Gln Ala Gln Asp Ala Tyr Phe Thr Lys 545 550 555 560 Asn Arg Ser Ala Phe Met Val Arg Glu Gly Leu Ser Ile Val Gln Asp 565 570 575 Ala Arg Asp Arg Ser Ala Gly Pro Gly Lys Trp Phe Asp Asn Glu Ala 580 585 590 Lys Ala Ser Glu Trp Leu Gly Asn Asn Ile Ala Leu Thr Arg Ala Arg 595 600 605 Val Ala Glu Glu Leu Gly Val Glu Glu Leu Ile Ala Leu Ser Ala Gln 610 615 620 Tyr Ala Asp Asp Pro Asp Phe Met Pro Ala Phe Ala Gly Glu Asp Glu 625 630 635 640 Leu Met Ala Ile Lys Gln Asp Tyr Trp Ala Met Leu Arg Gly Glu Glu 645 650 655 Thr Asp Leu Leu Asn Pro Gly Val Asn Arg Asp Asp Tyr Met Ala Ala 660 665 670 Ile Arg Asp Gly Asp His Glu Gln Ile Ala Ala Met Thr Ser Ala Met 675 680 685 Asn Ala Val Thr Val Glu Asp Arg Val Arg Gln His Ala Ala Leu Val 690 695 700 Leu Asp Asp Tyr Val Gly Thr Val Glu Pro Asp Pro Val Thr Gly Leu 705 710 715 720 Arg Phe Asn Pro Val Thr Val Ala Gln His Met Pro Ser Ala Lys Ser 725 730 735 Leu Trp Ser Asn His Asp Asp Ile Ile Ala Ala Leu Arg Ala Thr Ser 740 745 750 Ile Thr Gly Asp Glu Leu Arg Gly Asp Glu Phe Tyr Asn Asp Val Ile 755 760 765 Asn Gln Gln Leu Leu Lys Phe Asn Pro Glu Thr Ala Gln Lys Met Val 770 775 780 Asn Asn Pro Asp Leu Asp Pro Gln Leu Ala Arg Phe Gly Thr Val Ile 785 790 795 800 Ala Glu Thr Ile Ser Arg Asn Gly Ala Asp Val Val Asp Ile Ala Val 805 810 815 Asp Asp Asn Gly Val Val Arg Trp Thr Ala Gln Arg Arg Val Gly Ala 820 825 830 Lys Asp Ser Arg Ala Val Asp Ser Lys Gly Gln Val Arg Gly Glu Arg 835 840 845 Thr Arg His Val Gln Gly Glu Ile Gly Gln Ile Phe Thr Arg Gly Glu 850 855 860 His Gly Glu Ile Val Thr Lys Phe Asn Gly Gly Glu Asn Tyr Met Phe 865 870 875 880 Ala Pro Gly Tyr Thr Ala Ser Val Val Pro Gln Lys Pro Gly Glu Thr 885 890 895 Lys Ser Leu Glu Glu Arg Thr Lys Leu Lys Gly Tyr Glu Gln Val Met 900 905 910 Ser Glu Ala Leu Val Tyr Arg Val Arg Glu Asp Leu Met Phe Thr Glu 915 920 925 Arg Ser Arg Val Gly Ala Thr Thr Ser Ile Asn Ser Ala Tyr Lys Arg 930 935 940 Leu Tyr Asp Asn Arg Phe Pro Val Asp Phe Phe Glu Arg Ser Ala Glu 945 950 955 960 Glu Gly Leu Ser Asp Glu Trp Arg Ala Ala Leu Leu Glu Thr Ala Ser 965 970 975 Leu Arg Val Arg Tyr Asp Asn Ser Ile Arg Asp Gly Ala Asn Val Met 980 985 990 Glu Asp Ile Arg Ala Gln Gln Arg Gly Phe Asp Ala Arg Asn Asp Asn 995 1000 1005 Ser Arg Asp Ala Leu Val Leu Thr Gly Gly Arg Asn Ile Ser Val Leu 1010 1015 1020 Asp Val Asp Ala Gly Lys Gly Phe Phe Asp Pro Met Met Thr Gly Met 1025 1030 1035 1040 Ala Ala Asn Gln Gly Ser Val Arg Tyr Leu Leu Pro Ser Ala Lys Val 1045 1050 1055 Gly Ala Asp Gly Met Ile Thr Pro Gly Asp Pro Ala Asp Arg Val Pro 1060 1065 1070 Val Ala Ala His Pro Glu Ser Trp Ala Met Gly Phe Asp Pro His Asp 1075 1080 1085 Arg Gln Asn Met Thr Phe Ser Asn Ile Met Gln Ala Ser Ala Val Thr 1090 1095 1100 Gly Gly Ala Arg Thr Ala Met Ile Gln Leu Gly Gly Trp Asn Phe Glu 1105 1110 1115 1120 Asp Gly Ile Ile Val Ser Ala Asp Phe Ala Asn Thr His Val Ile Arg 1125 1130 1135 Asp Thr Glu Asp Glu Met Arg Pro Leu Val Ala Gly Asp Lys Leu Ser 1140 1145 1150 Asp Phe His Gly Asn Lys Gly Val Ile Ala Leu Val Val Asp Pro Ala 1155 1160 1165 Met Ser Asp Ala Asp Ala Arg Ala Ala Gly Leu Glu Ser Glu Val Ala 1170 1175 1180 Phe Phe Arg Asp Asn Pro Asp Leu Glu Val Val Met Ser Pro Phe Ser 1185 1190 1195 1200 Ala Ile Ser Arg Phe Asn Gly Gly Thr Ala Arg Glu Leu Met Asn Asn 1205 1210 1215 Pro Gln Asp Val Val Phe Arg Asn Asn Asp Gly Ser Thr Arg Val Gln 1220 1225 1230 Pro Gly Ala Ser Gly Asp Leu Asn Phe Ile Val Thr His Met Ala Val 1235 1240 1245 Asp Ala Lys Thr Asn Val Tyr Asp Glu Glu Ala Val Arg Glu Gly Gln 1250 1255 1260 Gly Arg Lys Ala Ser Ser Gln Leu Ala Trp Val Leu Gln Ala Gln Glu 1265 1270 1275 1280 Cys His Glu Ile Met Glu His Phe Tyr Gly Asn Asn Val Ser Ala Leu 1285 1290 1295 Ala Asn Phe Gln Glu Tyr Leu Arg Val Thr Gly Leu Asp Val Thr Pro 1300 1305 1310 Tyr Gly Glu Leu Arg Glu Gly Phe Ser Glu Ser Asn Glu Gln Arg Asn 1315 1320 1325 Ile Ile Glu Met Pro Ser Ile Tyr Asp Glu Asn Gly Glu Leu Asn Asn 1330 1335 1340 Arg Val Asn Arg Ala Gln Val Arg Glu Ala Phe Val Glu Gln Ile Ser 1345 1350 1355 1360 Arg Ala Gly Gly Val Met Glu Ile Pro Phe Gln Leu Gln Leu Arg Asn 1365 1370 1375 Gly Ala Gln Leu Glu Glu Ser Pro Asn Asn Pro Asp Met Tyr Gln Leu 1380 1385 1390 Pro Leu Leu Ser Pro His Leu Arg Ser Asp Glu Asp Leu Ala Asp Gly 1395 1400 1405 Ser Thr Ser Arg His Glu Tyr Thr Thr Arg Tyr Met Ala Ile Phe Asp 1410 1415 1420 Thr Cys Tyr Lys Leu Ala Glu Glu Gln Ala Lys Ile Asp Ala Leu Arg 1425 1430 1435 1440 Gln Glu Glu Ala Gln His Gly Thr Leu Pro Arg Ala Ala Glu Lys Arg 1445 1450 1455 Leu Ser Glu Ser Gln Lys Phe Val Asp Gln Ala Gln Lys Lys Val Gln 1460 1465 1470 Ala Ser Phe Asp Gly Ile Ala Asn Asp Ile Val Ala Ser Arg Ile Glu 1475 1480 1485 Thr Lys Asn Asn Val Phe Lys Asp Gly Phe Met Ser Ala Arg Gln Ser 1490 1495 1500 His Ser Ala Thr Ala Val Trp Thr Gly Asp Pro Arg Leu Ser Val Asp 1505 1510 1515 1520 Glu Val Ala Met Asn Ser Ser Met Ala Arg Glu Leu Gly Val Leu Asp 1525 1530 1535 Asn Gly Tyr Ala Met Val Trp Arg Asp Pro Val Ile Arg Asp Gly Gly 1540 1545 1550 Val Arg Tyr Leu Arg Val Val Ile Asn Asp Asp Leu His Gly Val Ala 1555 1560 1565 Val Asn Pro Val Ser Val Lys Ser Phe Asp Gly Asp Phe Asp Gly Asp 1570 1575 1580 Ser Val Gly Leu Val Gly Asn Leu Pro Lys Lys Ala His Glu Glu Ala 1585 1590 1595 1600 Leu Ser Arg Leu Thr Val Glu Ala Asn Met Leu Asp Leu Gly Asp Gly 1605 1610 1615 Lys Arg Met Glu Asp Gly Thr Met Phe Tyr Gly Leu Thr Leu His Asp 1620 1625 1630 Ser Leu Asp Val Gln Val Ala Gln His His Asp Pro Ala Met Ala Glu 1635 1640 1645 Asn Met Lys Val Ile Val Ser Glu Leu Asn Arg Tyr Gln Arg Glu Tyr 1650 1655 1660 Glu Ala Gly Glu Ile Ser Arg Glu Glu Leu Leu Glu Val Asn Arg Ala 1665 1670 1675 1680 His Met Asp Asp Leu Asn Glu His Tyr Ala Gln Ala Phe Ala Asn Arg 1685 1690 1695 Asp Gly Leu Val Thr Leu Arg Phe Asp Gly Met Glu Asn His Met Ala 1700 1705 1710 Ser Val Ala Gln Cys Phe Glu Thr Gly Ala Lys Gly Ser Pro Gly Lys 1715 1720 1725 Leu Lys Glu Tyr Ala Thr Tyr Ile Gly Ala Asp Pro Ala Gln Gly Phe 1730 1735 1740 Lys Asp Val Gly Gln Pro Thr Pro Glu Ala Leu Arg Ser His Tyr Glu 1745 1750 1755 1760 Gly Ser Gln Lys Ala Thr Ala Ile Lys Val Leu Phe Thr Gly Val Ala 1765 1770 1775 Gly Lys Lys Glu Gln Glu Met Val Ala Leu Cys Arg Asn Leu Gly Leu 1780 1785 1790 Thr Lys Glu Ala Met Ala Ala Ser Ala Pro Ala Gln Gln Ser Ile Leu 1795 1800 1805 Gln Ala Lys His Asp Pro Ile Asp Ala Leu Tyr Arg Ala Glu Thr Leu 1810 1815 1820 Met Gly Pro Val Gly Asp Leu Tyr Gln Gly Arg Lys Met Arg Arg Gly 1825 1830 1835 1840 Glu Asn Glu Gln Gly Arg Tyr Glu Trp Glu Val Val Arg Asp Glu Asn 1845 1850 1855 His Gln Pro Ile Gln Ala Thr Lys Asp Glu Trp Val Gln Gln Tyr Met 1860 1865 1870 Glu Met Tyr Ala Asp Asp Lys Gly Met Gly Val Ser Val Gly Val Asp 1875 1880 1885 Gln Val Glu Lys Ile Ala Glu Glu Phe Ser Asp Glu Gln Gly Tyr Met 1890 1895 1900 Arg Val Leu Ser His Asp Glu Leu Pro Thr Glu Ile Lys Pro Leu Ala 1905 1910 1915 1920 Leu Asp Gln Leu Ala Tyr Gly Asp Lys Lys Asn Arg Phe Asp Leu Leu 1925 1930 1935 Cys Glu Met Ala Lys Gln Gln Val Asn Ile Tyr Asp Gly Asp Ala Tyr 1940 1945 1950 Asp Phe Ala Pro Arg Val Val Arg Ala Asn Met Lys Ala Met Glu Asp 1955 1960 1965 Ala Ala Arg Phe Gly Ile Pro Asp Val Glu Ile Gln Ser Ile Ser Ala 1970 1975 1980 Gln Gln Ser Leu Ala Ser Phe Glu Arg Val Pro Gln Arg Ser Gly Phe 1985 1990 1995 2000 Arg Ile Glu Arg Arg Val Pro Ala Glu Val Gly Thr Gly Ile Ala Ala 2005 2010 2015 Pro Ala Pro Leu Pro Asp Ala Gly Val Gln Gly Asn Tyr Val Gln Gln 2020 2025 2030 Gln Val Pro Ala Thr Pro Pro Val Met Pro Val Thr Pro Pro Ala Gln 2035 2040 2045 Gln Pro Val Ser Pro Ala Gln Thr Asp Phe Arg Gly Val Gly Gln Pro 2050 2055 2060 Leu Asp Gln Gly Gly Lys Ile Gly Asn Tyr Gly His Gln Gly Pro Ala 2065 2070 2075 2080 Met Gly Ala Gln Gln Pro Val Val Pro Gln Gln Gln Asn Ile Pro Pro 2085 2090 2095 Val His Asn Pro Val Pro Gln Asn Ser Val Pro Pro Thr Pro Val Val 2100 2105 2110 Pro Lys Pro Gly Thr Gly Asn Pro Phe Thr His Gly Gly Ala Asn Asn 2115 2120 2125 Gln Phe Met Gly Arg Phe Asp Thr Ser Arg Tyr Asn Gln Gln Glu Pro 2130 2135 2140 Pro Gln Arg Gln Asp Gly Gly Phe Glu Leu 2145 2150 <210> 173 <211> 1216 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1186) <223> RXA01628 <400> 173 attaagaaaa aatgaattaa accaaaactt cttaatcgca ggggttaagg taagttcagc 60 taatcaatga aacttcccct ttcagcccgt tgaagaacca atg agc cct gcc cgc 115 Met Ser Pro Ala Arg 1 5 acc cag ccc cga gcg gct ttc cta agg aag ctc cga ccc atc aca tgt 163 Thr Gln Pro Arg Ala Ala Phe Leu Arg Lys Leu Arg Pro Ile Thr Cys 10 15 20 agc ctt tcc ttg gtt ctc gta ggg tgc agc aac acg gca gag tcc acg 211 Ser Leu Ser Leu Val Leu Val Gly Cys Ser Asn Thr Ala Glu Ser Thr 25 30 35 acc acc gat acg gca ggc tcc act gaa act tca tca cag att tca ccc 259 Thr Thr Asp Thr Ala Gly Ser Thr Glu Thr Ser Ser Gln Ile Ser Pro 40 45 50 acc act cca gtc agc acc acc gaa gca gcg ccg cct gaa gat cca agc 307 Thr Thr Pro Val Ser Thr Thr Glu Ala Ala Pro Pro Glu Asp Pro Ser 55 60 65 gca aac gct ttg gaa gag tat gct cag atc ctt gcc aat cca agc atc 355 Ala Asn Ala Leu Glu Glu Tyr Ala Gln Ile Leu Ala Asn Pro Ser Ile 70 75 80 85 tac ccc tta acc gaa att tca caa ttc gtc ccc aca ggc aca tat gcc 403 Tyr Pro Leu Thr Glu Ile Ser Gln Phe Val Pro Thr Gly Thr Tyr Ala 90 95 100 tac aca ctt gtt gaa gca act tcc gat tcc atc cca gaa cta cta ctc 451 Tyr Thr Leu Val Glu Ala Thr Ser Asp Ser Ile Pro Glu Leu Leu Leu 105 110 115 cgc gcc gat agt cac gaa ttc gcg cca att ttg gtt ttc acc tat gac 499 Arg Ala Asp Ser His Glu Phe Ala Pro Ile Leu Val Phe Thr Tyr Asp 120 125 130 gaa aac aca caa tcc gca acc caa gct gga gga gtc cta att gac ggt 547 Glu Asn Thr Gln Ser Ala Thr Gln Ala Gly Gly Val Leu Ile Asp Gly 135 140 145 gtc gcc agc gcc ggc ggt tca cga gtc aag gtc aga gct tca aat tca 595 Val Ala Ser Ala Gly Gly Ser Arg Val Lys Val Arg Ala Ser Asn Ser 150 155 160 165 gga gca gga atc tac caa ttg aat tgg tac tcg ata caa cca gtt ggc 643 Gly Ala Gly Ile Tyr Gln Leu Asn Trp Tyr Ser Ile Gln Pro Val Gly 170 175 180 gaa agc tct ttg tac gga atc caa gga aac tcc ctg aca caa atc gca 691 Glu Ser Ser Leu Tyr Gly Ile Gln Gly Asn Ser Leu Thr Gln Ile Ala 185 190 195 gac ccc gag gat ttc atg gtc cgt gaa cta tta cct gac cac cac gaa 739 Asp Pro Glu Asp Phe Met Val Arg Glu Leu Leu Pro Asp His His Glu 200 205 210 att acc tgg gtt gat tcc aac gac ccc tcc ggc cta tca acc gtt cag 787 Ile Thr Trp Val Asp Ser Asn Asp Pro Ser Gly Leu Ser Thr Val Gln 215 220 225 act ggt gga gcc aac att caa caa gca gcc cca act ccc gtt caa cag 835 Thr Gly Gly Ala Asn Ile Gln Gln Ala Ala Pro Thr Pro Val Gln Gln 230 235 240 245 cct gcg tca aac ctg cac tac ttc tct ggt gta gta acg atg cag acc 883 Pro Ala Ser Asn Leu His Tyr Phe Ser Gly Val Val Thr Met Gln Thr 250 255 260 gcc ggc gaa ctc atg cga ggt gaa cga act ccc aat ggt gag cct gcc 931 Ala Gly Glu Leu Met Arg Gly Glu Arg Thr Pro Asn Gly Glu Pro Ala 265 270 275 act gat ctc tat ctc gta ctg gtc ctt gat tcc cca att gaa atc aca 979 Thr Asp Leu Tyr Leu Val Leu Val Leu Asp Ser Pro Ile Glu Ile Thr 280 285 290 gca cga aac gca gct aca gac cct cag act cgt acc att tcc gaa gtc 1027 Ala Arg Asn Ala Ala Thr Asp Pro Gln Thr Arg Thr Ile Ser Glu Val 295 300 305 agc ctc ggc cga tac atc ccc gct gat ggt gac aat gat tgg ata ggc 1075 Ser Leu Gly Arg Tyr Ile Pro Ala Asp Gly Asp Asn Asp Trp Ile Gly 310 315 320 325 tac ctc gac acc cac gtg gaa atc act gca aca acg gat cag gtc tgg 1123 Tyr Leu Asp Thr His Val Glu Ile Thr Ala Thr Thr Asp Gln Val Trp 330 335 340 ttc cca acc gac acc ggt cta cct ctt gga atg ctt cgt cta gcg gac 1171 Phe Pro Thr Asp Thr Gly Leu Pro Leu Gly Met Leu Arg Leu Ala Asp 345 350 355 tac aaa agc atc tca taaaccgacg cagcactcgt cgataagcac 1216 Tyr Lys Ser Ile Ser 360 <210> 174 <211> 362 <212> PRT <213> Corynebacterium glutamicum <400> 174 Met Ser Pro Ala Arg Thr Gln Pro Arg Ala Ala Phe Leu Arg Lys Leu 1 5 10 15 Arg Pro Ile Thr Cys Ser Leu Ser Leu Val Leu Val Gly Cys Ser Asn 20 25 30 Thr Ala Glu Ser Thr Thr Thr Asp Thr Ala Gly Ser Thr Glu Thr Ser 35 40 45 Ser Gln Ile Ser Pro Thr Thr Pro Val Ser Thr Thr Glu Ala Ala Pro 50 55 60 Pro Glu Asp Pro Ser Ala Asn Ala Leu Glu Glu Tyr Ala Gln Ile Leu 65 70 75 80 Ala Asn Pro Ser Ile Tyr Pro Leu Thr Glu Ile Ser Gln Phe Val Pro 85 90 95 Thr Gly Thr Tyr Ala Tyr Thr Leu Val Glu Ala Thr Ser Asp Ser Ile 100 105 110 Pro Glu Leu Leu Leu Arg Ala Asp Ser His Glu Phe Ala Pro Ile Leu 115 120 125 Val Phe Thr Tyr Asp Glu Asn Thr Gln Ser Ala Thr Gln Ala Gly Gly 130 135 140 Val Leu Ile Asp Gly Val Ala Ser Ala Gly Gly Ser Arg Val Lys Val 145 150 155 160 Arg Ala Ser Asn Ser Gly Ala Gly Ile Tyr Gln Leu Asn Trp Tyr Ser 165 170 175 Ile Gln Pro Val Gly Glu Ser Ser Leu Tyr Gly Ile Gln Gly Asn Ser 180 185 190 Leu Thr Gln Ile Ala Asp Pro Glu Asp Phe Met Val Arg Glu Leu Leu 195 200 205 Pro Asp His His Glu Ile Thr Trp Val Asp Ser Asn Asp Pro Ser Gly 210 215 220 Leu Ser Thr Val Gln Thr Gly Gly Ala Asn Ile Gln Gln Ala Ala Pro 225 230 235 240 Thr Pro Val Gln Gln Pro Ala Ser Asn Leu His Tyr Phe Ser Gly Val 245 250 255 Val Thr Met Gln Thr Ala Gly Glu Leu Met Arg Gly Glu Arg Thr Pro 260 265 270 Asn Gly Glu Pro Ala Thr Asp Leu Tyr Leu Val Leu Val Leu Asp Ser 275 280 285 Pro Ile Glu Ile Thr Ala Arg Asn Ala Ala Thr Asp Pro Gln Thr Arg 290 295 300 Thr Ile Ser Glu Val Ser Leu Gly Arg Tyr Ile Pro Ala Asp Gly Asp 305 310 315 320 Asn Asp Trp Ile Gly Tyr Leu Asp Thr His Val Glu Ile Thr Ala Thr 325 330 335 Thr Asp Gln Val Trp Phe Pro Thr Asp Thr Gly Leu Pro Leu Gly Met 340 345 350 Leu Arg Leu Ala Asp Tyr Lys Ser Ile Ser 355 360 <210> 175 <211> 1381 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1351) <223> RXA01642 <400> 175 cttgaaaggt tggaatcact gtgtcttgca gctagtctgc cactcgcact gcatttgctg 60 gatgtatttg gaatgctgcg cggtcttgat attggattcg gtg gat aag atg cgc 115 Val Asp Lys Met Arg 1 5 aga ctc atc gcg gtt agc ttg gcc gct ctg ttt atg ttg gct tcc act 163 Arg Leu Ile Ala Val Ser Leu Ala Ala Leu Phe Met Leu Ala Ser Thr 10 15 20 cca gcg acg agg gca cag gaa gta gaa gct ctc gct tgc ccc gag gta 211 Pro Ala Thr Arg Ala Gln Glu Val Glu Ala Leu Ala Cys Pro Glu Val 25 30 35 gcg atc gcc gat cct tcc tcc gca gtt tta gat gaa cac ctt tcg cag 259 Ala Ile Ala Asp Pro Ser Ser Ala Val Leu Asp Glu His Leu Ser Gln 40 45 50 tca tta tcc caa gct cac caa cta gca act ggc gcc ggt gtg atg gtg 307 Ser Leu Ser Gln Ala His Gln Leu Ala Thr Gly Ala Gly Val Met Val 55 60 65 gca gtc atc gac acc gga gta tcc ctg cat cca cgt ctg ccc cac tta 355 Ala Val Ile Asp Thr Gly Val Ser Leu His Pro Arg Leu Pro His Leu 70 75 80 85 att ccc ggc ggt gat ttc gtg ggc gcc cac caa agc ccc gat gtg cca 403 Ile Pro Gly Gly Asp Phe Val Gly Ala His Gln Ser Pro Asp Val Pro 90 95 100 ggt gaa ctt atc gat tgc gac ggc cac ggc acc atc gtc gcc gga atc 451 Gly Glu Leu Ile Asp Cys Asp Gly His Gly Thr Ile Val Ala Gly Ile 105 110 115 atc gcc tcc caa gga aac ccc ggc acc ggc tgg cca tat gac ggc agc 499 Ile Ala Ser Gln Gly Asn Pro Gly Thr Gly Trp Pro Tyr Asp Gly Ser 120 125 130 tcc gat cct tat atc ggt gtc gcc cca gat tcc gga atc atc tcc att 547 Ser Asp Pro Tyr Ile Gly Val Ala Pro Asp Ser Gly Ile Ile Ser Ile 135 140 145 aaa caa acc agc tca tat gtg cgt act cgt gaa gat tcc aac gtc gga 595 Lys Gln Thr Ser Ser Tyr Val Arg Thr Arg Glu Asp Ser Asn Val Gly 150 155 160 165 acg ctg agc acc ctg gcg gaa tcc atc cac cga gct ctc gat tcc ggt 643 Thr Leu Ser Thr Leu Ala Glu Ser Ile His Arg Ala Leu Asp Ser Gly 170 175 180 gcc cac gtg atc aat att tcc gtg gtg tcc tgt ttg ccc caa tca ccc 691 Ala His Val Ile Asn Ile Ser Val Val Ser Cys Leu Pro Gln Ser Pro 185 190 195 gac gag gcc gca tcg ttc cag cct ctg acg gat gct ctt aac aga gca 739 Asp Glu Ala Ala Ser Phe Gln Pro Leu Thr Asp Ala Leu Asn Arg Ala 200 205 210 gaa ctt caa ggg gtg ata gtg gtg gca gca gca gga aac ctc ggg cag 787 Glu Leu Gln Gly Val Ile Val Val Ala Ala Ala Gly Asn Leu Gly Gln 215 220 225 gat tgt cca gtt gga tct acc gtt tat cct gca cat tca gac act gtg 835 Asp Cys Pro Val Gly Ser Thr Val Tyr Pro Ala His Ser Asp Thr Val 230 235 240 245 ctc tct gtg tcg gca cgt ttt gat tct cac acg ctt gca gaa tat tcc 883 Leu Ser Val Ser Ala Arg Phe Asp Ser His Thr Leu Ala Glu Tyr Ser 250 255 260 atg cct ggc aac caa caa atc ctc tct gca cca agc cac att cag gct 931 Met Pro Gly Asn Gln Gln Ile Leu Ser Ala Pro Ser His Ile Gln Ala 265 270 275 ggt cta tca ccg cgt ggc gac ggc ttc gcc agc cac atg atc acc acc 979 Gly Leu Ser Pro Arg Gly Asp Gly Phe Ala Ser His Met Ile Thr Thr 280 285 290 gct ggc gaa agc ccc ttc gag ggc acc agt ttt gcc gct cca gtt gtc 1027 Ala Gly Glu Ser Pro Phe Glu Gly Thr Ser Phe Ala Ala Pro Val Val 295 300 305 agc gcc aca gct gca ctg ctt cgc cag cat ttt ccc ttt gcc aca ccc 1075 Ser Ala Thr Ala Ala Leu Leu Arg Gln His Phe Pro Phe Ala Thr Pro 310 315 320 325 tat gaa att cgt gca cga atc ttc aac agc atc gac cct gca aga ggc 1123 Tyr Glu Ile Arg Ala Arg Ile Phe Asn Ser Ile Asp Pro Ala Arg Gly 330 335 340 gct att gat ccc tac ctg gca ctt act caa gaa atc tat ccc acc act 1171 Ala Ile Asp Pro Tyr Leu Ala Leu Thr Gln Glu Ile Tyr Pro Thr Thr 345 350 355 ccc ctg gtt cat gag atc gca cta agt gtt ccc acg ccg ccg gat gat 1219 Pro Leu Val His Glu Ile Ala Leu Ser Val Pro Thr Pro Pro Asp Asp 360 365 370 tct cca cgg gag cgg ggc atc cta gtt acc gca atc att gtt ggg ttg 1267 Ser Pro Arg Glu Arg Gly Ile Leu Val Thr Ala Ile Ile Val Gly Leu 375 380 385 ctc gca gtg tta gct gtg ctg atg gga cta cgc cga att cat cat cac 1315 Leu Ala Val Leu Ala Val Leu Met Gly Leu Arg Arg Ile His His His 390 395 400 405 tcg gcc ttt caa aaa gct agc tca agt gtt atc act taatctatga 1361 Ser Ala Phe Gln Lys Ala Ser Ser Ser Val Ile Thr 410 415 ggcaccgttc agaatcccat 1381 <210> 176 <211> 417 <212> PRT <213> Corynebacterium glutamicum <400> 176 Val Asp Lys Met Arg Arg Leu Ile Ala Val Ser Leu Ala Ala Leu Phe 1 5 10 15 Met Leu Ala Ser Thr Pro Ala Thr Arg Ala Gln Glu Val Glu Ala Leu 20 25 30 Ala Cys Pro Glu Val Ala Ile Ala Asp Pro Ser Ser Ala Val Leu Asp 35 40 45 Glu His Leu Ser Gln Ser Leu Ser Gln Ala His Gln Leu Ala Thr Gly 50 55 60 Ala Gly Val Met Val Ala Val Ile Asp Thr Gly Val Ser Leu His Pro 65 70 75 80 Arg Leu Pro His Leu Ile Pro Gly Gly Asp Phe Val Gly Ala His Gln 85 90 95 Ser Pro Asp Val Pro Gly Glu Leu Ile Asp Cys Asp Gly His Gly Thr 100 105 110 Ile Val Ala Gly Ile Ile Ala Ser Gln Gly Asn Pro Gly Thr Gly Trp 115 120 125 Pro Tyr Asp Gly Ser Ser Asp Pro Tyr Ile Gly Val Ala Pro Asp Ser 130 135 140 Gly Ile Ile Ser Ile Lys Gln Thr Ser Ser Tyr Val Arg Thr Arg Glu 145 150 155 160 Asp Ser Asn Val Gly Thr Leu Ser Thr Leu Ala Glu Ser Ile His Arg 165 170 175 Ala Leu Asp Ser Gly Ala His Val Ile Asn Ile Ser Val Val Ser Cys 180 185 190 Leu Pro Gln Ser Pro Asp Glu Ala Ala Ser Phe Gln Pro Leu Thr Asp 195 200 205 Ala Leu Asn Arg Ala Glu Leu Gln Gly Val Ile Val Val Ala Ala Ala 210 215 220 Gly Asn Leu Gly Gln Asp Cys Pro Val Gly Ser Thr Val Tyr Pro Ala 225 230 235 240 His Ser Asp Thr Val Leu Ser Val Ser Ala Arg Phe Asp Ser His Thr 245 250 255 Leu Ala Glu Tyr Ser Met Pro Gly Asn Gln Gln Ile Leu Ser Ala Pro 260 265 270 Ser His Ile Gln Ala Gly Leu Ser Pro Arg Gly Asp Gly Phe Ala Ser 275 280 285 His Met Ile Thr Thr Ala Gly Glu Ser Pro Phe Glu Gly Thr Ser Phe 290 295 300 Ala Ala Pro Val Val Ser Ala Thr Ala Ala Leu Leu Arg Gln His Phe 305 310 315 320 Pro Phe Ala Thr Pro Tyr Glu Ile Arg Ala Arg Ile Phe Asn Ser Ile 325 330 335 Asp Pro Ala Arg Gly Ala Ile Asp Pro Tyr Leu Ala Leu Thr Gln Glu 340 345 350 Ile Tyr Pro Thr Thr Pro Leu Val His Glu Ile Ala Leu Ser Val Pro 355 360 365 Thr Pro Pro Asp Asp Ser Pro Arg Glu Arg Gly Ile Leu Val Thr Ala 370 375 380 Ile Ile Val Gly Leu Leu Ala Val Leu Ala Val Leu Met Gly Leu Arg 385 390 395 400 Arg Ile His His His Ser Ala Phe Gln Lys Ala Ser Ser Ser Val Ile 405 410 415 Thr <210> 177 <211> 1387 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1357) <223> RXA01647 <400> 177 gcaaatctga gaatcttccc actttcacta gtcttatccc ggaccagcgc actacagttc 60 ctggattagg ggatgtaaag atctaaagct gggggaatac atg gct gaa ggc atg 115 Met Ala Glu Gly Met 1 5 ttg atg ccc acg aca tcg gcg cag gtg tcg ggg cat aaa ttt ctg gtg 163 Leu Met Pro Thr Thr Ser Ala Gln Val Ser Gly His Lys Phe Leu Val 10 15 20 cgg cgc atc gaa cat ggg ttg gtg atg ggc gat gtg cgc atg att cat 211 Arg Arg Ile Glu His Gly Leu Val Met Gly Asp Val Arg Met Ile His 25 30 35 gat cca ctt ggt agg cgc cgg cgg gcg ttg gtg ttt ggg gtg gtg gcg 259 Asp Pro Leu Gly Arg Arg Arg Arg Ala Leu Val Phe Gly Val Val Ala 40 45 50 tgc gtg atg ttg gcg gtg gga tca ttg gcg ttg gct att ttt cga ccc 307 Cys Val Met Leu Ala Val Gly Ser Leu Ala Leu Ala Ile Phe Arg Pro 55 60 65 gcg aag gat ccg gcc gat gcg ccg ttg atc cgc tct gaa tcc ggc gcg 355 Ala Lys Asp Pro Ala Asp Ala Pro Leu Ile Arg Ser Glu Ser Gly Ala 70 75 80 85 ctc ttt gtg cag ctg gat ggg tcg gtg cat ccg gtg gct aat gtg gcc 403 Leu Phe Val Gln Leu Asp Gly Ser Val His Pro Val Ala Asn Val Ala 90 95 100 tcg gct cgg ttg att gtg ggg gag ccg gtg gat ccg gtg aac gcc agc 451 Ser Ala Arg Leu Ile Val Gly Glu Pro Val Asp Pro Val Asn Ala Ser 105 110 115 gat gcg atc atc gcg ggc atg ccg cgc gga gtg ccg gtg ggg gtt cct 499 Asp Ala Ile Ile Ala Gly Met Pro Arg Gly Val Pro Val Gly Val Pro 120 125 130 gat gcg ccg ggg ctt ttc agc agc acc gaa gaa ccc gag caa gat tgg 547 Asp Ala Pro Gly Leu Phe Ser Ser Thr Glu Glu Pro Glu Gln Asp Trp 135 140 145 ttt gtg tgc cag gat gtc ggc act ggg gat cta cac att acg gtt cct 595 Phe Val Cys Gln Asp Val Gly Thr Gly Asp Leu His Ile Thr Val Pro 150 155 160 165 agg ggc gga cta ggg ccc acc ctg att gcg gaa gga aat ggg tgg ctg 643 Arg Gly Gly Leu Gly Pro Thr Leu Ile Ala Glu Gly Asn Gly Trp Leu 170 175 180 ggg gcg tcg aaa agc gaa acc ggc gag gtc acc tgg aac ctg att acc 691 Gly Ala Ser Lys Ser Glu Thr Gly Glu Val Thr Trp Asn Leu Ile Thr 185 190 195 gcg gac ggg cgc cgc gaa ctg ccg gcg tgg ggc agc gaa cat ggg cgc 739 Ala Asp Gly Arg Arg Glu Leu Pro Ala Trp Gly Ser Glu His Gly Arg 200 205 210 att atg cgc cgc cac ctg ggg att tcc gag gac acc ccg cgc gta tac 787 Ile Met Arg Arg His Leu Gly Ile Ser Glu Asp Thr Pro Arg Val Tyr 215 220 225 ctg acc act gag ctg ctc aac gcg atc ccc gag cac gac gcg gtc cgc 835 Leu Thr Thr Glu Leu Leu Asn Ala Ile Pro Glu His Asp Ala Val Arg 230 235 240 245 ttc cca gcc ccg ctg ccc gag ctt gtc gac gcc tcc acc cgc aac tgg 883 Phe Pro Ala Pro Leu Pro Glu Leu Val Asp Ala Ser Thr Arg Asn Trp 250 255 260 tta cgg ctc gac ggg gcg ctc gcc gaa atc acg ccg cta cag cgc ggg 931 Leu Arg Leu Asp Gly Ala Leu Ala Glu Ile Thr Pro Leu Gln Arg Gly 265 270 275 ttg ctt atc gac gcc ggt tcc ggt gtt ttc ccc gac ccc acc gcg ctt 979 Leu Leu Ile Asp Ala Gly Ser Gly Val Phe Pro Asp Pro Thr Ala Leu 280 285 290 ctt ggt gtg cat gaa gaa aca gcc aac acc ttg acg ctg ccc gag caa 1027 Leu Gly Val His Glu Glu Thr Ala Asn Thr Leu Thr Leu Pro Glu Gln 295 300 305 aca gtt tct tgg caa gat ctg gac ggt ggt ttt gcc tgc gcg gat ggt 1075 Thr Val Ser Trp Gln Asp Leu Asp Gly Gly Phe Ala Cys Ala Asp Gly 310 315 320 325 gaa ggc cag atc ggt ttc ctg gaa act ctg gaa tcg ggg gtg gcg cta 1123 Glu Gly Gln Ile Gly Phe Leu Glu Thr Leu Glu Ser Gly Val Ala Leu 330 335 340 tct ggt gat tcc agg gcg aaa agt ttc agc aca aac gct ggt ggg gca 1171 Ser Gly Asp Ser Arg Ala Lys Ser Phe Ser Thr Asn Ala Gly Gly Ala 345 350 355 gtg ggc gtg gac agt ggc ttt ggc tac tat gtg gtc tct gat ttt ggg 1219 Val Gly Val Asp Ser Gly Phe Gly Tyr Tyr Val Val Ser Asp Phe Gly 360 365 370 ctg atg cac cct gtt tct act ggt gaa tcg atg gtt gcc cta gga atc 1267 Leu Met His Pro Val Ser Thr Gly Glu Ser Met Val Ala Leu Gly Ile 375 380 385 act gac gtg cag gtc gtg ccg tgg agc gtg ctg cga ttg ttg ccg cag 1315 Thr Asp Val Gln Val Val Pro Trp Ser Val Leu Arg Leu Leu Pro Gln 390 395 400 405 gga agt gaa tta gca aaa gag aca gcg ctc gcg ccc acc tat 1357 Gly Ser Glu Leu Ala Lys Glu Thr Ala Leu Ala Pro Thr Tyr 410 415 taaggagtat ggtggcctta catgagcgga 1387 <210> 178 <211> 419 <212> PRT <213> Corynebacterium glutamicum <400> 178 Met Ala Glu Gly Met Leu Met Pro Thr Thr Ser Ala Gln Val Ser Gly 1 5 10 15 His Lys Phe Leu Val Arg Arg Ile Glu His Gly Leu Val Met Gly Asp 20 25 30 Val Arg Met Ile His Asp Pro Leu Gly Arg Arg Arg Arg Ala Leu Val 35 40 45 Phe Gly Val Val Ala Cys Val Met Leu Ala Val Gly Ser Leu Ala Leu 50 55 60 Ala Ile Phe Arg Pro Ala Lys Asp Pro Ala Asp Ala Pro Leu Ile Arg 65 70 75 80 Ser Glu Ser Gly Ala Leu Phe Val Gln Leu Asp Gly Ser Val His Pro 85 90 95 Val Ala Asn Val Ala Ser Ala Arg Leu Ile Val Gly Glu Pro Val Asp 100 105 110 Pro Val Asn Ala Ser Asp Ala Ile Ile Ala Gly Met Pro Arg Gly Val 115 120 125 Pro Val Gly Val Pro Asp Ala Pro Gly Leu Phe Ser Ser Thr Glu Glu 130 135 140 Pro Glu Gln Asp Trp Phe Val Cys Gln Asp Val Gly Thr Gly Asp Leu 145 150 155 160 His Ile Thr Val Pro Arg Gly Gly Leu Gly Pro Thr Leu Ile Ala Glu 165 170 175 Gly Asn Gly Trp Leu Gly Ala Ser Lys Ser Glu Thr Gly Glu Val Thr 180 185 190 Trp Asn Leu Ile Thr Ala Asp Gly Arg Arg Glu Leu Pro Ala Trp Gly 195 200 205 Ser Glu His Gly Arg Ile Met Arg Arg His Leu Gly Ile Ser Glu Asp 210 215 220 Thr Pro Arg Val Tyr Leu Thr Thr Glu Leu Leu Asn Ala Ile Pro Glu 225 230 235 240 His Asp Ala Val Arg Phe Pro Ala Pro Leu Pro Glu Leu Val Asp Ala 245 250 255 Ser Thr Arg Asn Trp Leu Arg Leu Asp Gly Ala Leu Ala Glu Ile Thr 260 265 270 Pro Leu Gln Arg Gly Leu Leu Ile Asp Ala Gly Ser Gly Val Phe Pro 275 280 285 Asp Pro Thr Ala Leu Leu Gly Val His Glu Glu Thr Ala Asn Thr Leu 290 295 300 Thr Leu Pro Glu Gln Thr Val Ser Trp Gln Asp Leu Asp Gly Gly Phe 305 310 315 320 Ala Cys Ala Asp Gly Glu Gly Gln Ile Gly Phe Leu Glu Thr Leu Glu 325 330 335 Ser Gly Val Ala Leu Ser Gly Asp Ser Arg Ala Lys Ser Phe Ser Thr 340 345 350 Asn Ala Gly Gly Ala Val Gly Val Asp Ser Gly Phe Gly Tyr Tyr Val 355 360 365 Val Ser Asp Phe Gly Leu Met His Pro Val Ser Thr Gly Glu Ser Met 370 375 380 Val Ala Leu Gly Ile Thr Asp Val Gln Val Val Pro Trp Ser Val Leu 385 390 395 400 Arg Leu Leu Pro Gln Gly Ser Glu Leu Ala Lys Glu Thr Ala Leu Ala 405 410 415 Pro Thr Tyr <210> 179 <211> 472 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(442) <223> RXA01672 <400> 179 agtagcaaag ggtgcagtcg aaggaccagc atccaagact gctgccgaag aaaccgactc 60 cgttgacaac ggatccgacg aaaacggcga ggaataattt atg gca tcc cga gaa 115 Met Ala Ser Arg Glu 1 5 gta tcc atc acc cga atc tca cca cta gca acc ttc cga gtt gca ctg 163 Val Ser Ile Thr Arg Ile Ser Pro Leu Ala Thr Phe Arg Val Ala Leu 10 15 20 gca atg tcc atc atc gga ctc gtg gcg tgg atc atc tgc gta acc gtc 211 Ala Met Ser Ile Ile Gly Leu Val Ala Trp Ile Ile Cys Val Thr Val 25 30 35 ctc tat ttc gga ctt aac gtg gct ggc gtc tgg cag aac ttc aac gat 259 Leu Tyr Phe Gly Leu Asn Val Ala Gly Val Trp Gln Asn Phe Asn Asp 40 45 50 gtc atc ggc ggt gtt ggt gca gaa caa acc atc acc ttc ggg ctc gtc 307 Val Ile Gly Gly Val Gly Ala Glu Gln Thr Ile Thr Phe Gly Leu Val 55 60 65 ctg agc att tcc gca ctt ctg gga gct atc gga gcg att acc gtc gct 355 Leu Ser Ile Ser Ala Leu Leu Gly Ala Ile Gly Ala Ile Thr Val Ala 70 75 80 85 gtg ctt gca cca ttg tgt gca atc atc tac aac tcg att gtt gac ctc 403 Val Leu Ala Pro Leu Cys Ala Ile Ile Tyr Asn Ser Ile Val Asp Leu 90 95 100 ttc ggt gga ctg cag att caa ctg caa gaa gaa gta gac taacctctga 452 Phe Gly Gly Leu Gln Ile Gln Leu Gln Glu Glu Val Asp 105 110 aacacaaacc cctagacact 472 <210> 180 <211> 114 <212> PRT <213> Corynebacterium glutamicum <400> 180 Met Ala Ser Arg Glu Val Ser Ile Thr Arg Ile Ser Pro Leu Ala Thr 1 5 10 15 Phe Arg Val Ala Leu Ala Met Ser Ile Ile Gly Leu Val Ala Trp Ile 20 25 30 Ile Cys Val Thr Val Leu Tyr Phe Gly Leu Asn Val Ala Gly Val Trp 35 40 45 Gln Asn Phe Asn Asp Val Ile Gly Gly Val Gly Ala Glu Gln Thr Ile 50 55 60 Thr Phe Gly Leu Val Leu Ser Ile Ser Ala Leu Leu Gly Ala Ile Gly 65 70 75 80 Ala Ile Thr Val Ala Val Leu Ala Pro Leu Cys Ala Ile Ile Tyr Asn 85 90 95 Ser Ile Val Asp Leu Phe Gly Gly Leu Gln Ile Gln Leu Gln Glu Glu 100 105 110 Val Asp <210> 181 <211> 874 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(844) <223> RXA01677 <400> 181 gtcgccatag ttgagtttta ttcatggctt ttagctaggc gactttagtt gagggctttt 60 agttgagggc ttcccagcag ggatggttaa ggagaattca gtg aac caa cag agt 115 Val Asn Gln Gln Ser 1 5 aaa aag tgg ctc gta ccg aca ctg gtc gtc atc att gca gtg ctc ctc 163 Lys Lys Trp Leu Val Pro Thr Leu Val Val Ile Ile Ala Val Leu Leu 10 15 20 atc gca gtt gtt ctg ttg atg tac cga gga aat gcg agt gat acg gcc 211 Ile Ala Val Val Leu Leu Met Tyr Arg Gly Asn Ala Ser Asp Thr Ala 25 30 35 gag ggc gtt tca gcc gct gcg act tcg gac tcg gct gct gct tcg act 259 Glu Gly Val Ser Ala Ala Ala Thr Ser Asp Ser Ala Ala Ala Ser Thr 40 45 50 gct gct tcg ggt tcc gct tct ggt gct gcg gac tcc gat ctg acc agc 307 Ala Ala Ser Gly Ser Ala Ser Gly Ala Ala Asp Ser Asp Leu Thr Ser 55 60 65 gtg gaa gca cgc gac cct tcc gac cct gtt gcg gtg gga gac gtt gat 355 Val Glu Ala Arg Asp Pro Ser Asp Pro Val Ala Val Gly Asp Val Asp 70 75 80 85 gca cct gtt ggg tta gtg gtg ttt tcc gac tac caa tgc ccg ttc tgt 403 Ala Pro Val Gly Leu Val Val Phe Ser Asp Tyr Gln Cys Pro Phe Cys 90 95 100 gca aag tgg agc gat gaa acc ctg cca cag atg atg aag cat gtg gaa 451 Ala Lys Trp Ser Asp Glu Thr Leu Pro Gln Met Met Lys His Val Glu 105 110 115 gat gga aac ctc cgc att gaa tgg cgt gaa gtg aac atc ttt gga gaa 499 Asp Gly Asn Leu Arg Ile Glu Trp Arg Glu Val Asn Ile Phe Gly Glu 120 125 130 cca tct gag cgt gga gct cgc gcg gca tac gct gcg ggt ttg cag gac 547 Pro Ser Glu Arg Gly Ala Arg Ala Ala Tyr Ala Ala Gly Leu Gln Asp 135 140 145 gca tac ttg gaa tac cac aac gca ctc ttt gcc aac ggt gaa aaa ccc 595 Ala Tyr Leu Glu Tyr His Asn Ala Leu Phe Ala Asn Gly Glu Lys Pro 150 155 160 165 agc gaa gac ctg ctc agc gaa gag gga ctt att aag ctt gct ggt gac 643 Ser Glu Asp Leu Leu Ser Glu Glu Gly Leu Ile Lys Leu Ala Gly Asp 170 175 180 ctt gga cta gac gaa tcg aaa ttc act gcc gat ttc caa tcc cct gaa 691 Leu Gly Leu Asp Glu Ser Lys Phe Thr Ala Asp Phe Gln Ser Pro Glu 185 190 195 act gca gtc gca att gcg caa cat caa cag ctg gga atc gat ctt ggc 739 Thr Ala Val Ala Ile Ala Gln His Gln Gln Leu Gly Ile Asp Leu Gly 200 205 210 gcc tac tcc acc cca gct ttc ctc cta ggt ggc cag cca atc atg ggc 787 Ala Tyr Ser Thr Pro Ala Phe Leu Leu Gly Gly Gln Pro Ile Met Gly 215 220 225 gct cag cct gct tct gta ttt gaa gcc gcc ttc gag caa gca ctg gca 835 Ala Gln Pro Ala Ser Val Phe Glu Ala Ala Phe Glu Gln Ala Leu Ala 230 235 240 245 gcg aaa gaa taaaccgtgg atgtcggcct agttacagct 874 Ala Lys Glu <210> 182 <211> 248 <212> PRT <213> Corynebacterium glutamicum <400> 182 Val Asn Gln Gln Ser Lys Lys Trp Leu Val Pro Thr Leu Val Val Ile 1 5 10 15 Ile Ala Val Leu Leu Ile Ala Val Val Leu Leu Met Tyr Arg Gly Asn 20 25 30 Ala Ser Asp Thr Ala Glu Gly Val Ser Ala Ala Ala Thr Ser Asp Ser 35 40 45 Ala Ala Ala Ser Thr Ala Ala Ser Gly Ser Ala Ser Gly Ala Ala Asp 50 55 60 Ser Asp Leu Thr Ser Val Glu Ala Arg Asp Pro Ser Asp Pro Val Ala 65 70 75 80 Val Gly Asp Val Asp Ala Pro Val Gly Leu Val Val Phe Ser Asp Tyr 85 90 95 Gln Cys Pro Phe Cys Ala Lys Trp Ser Asp Glu Thr Leu Pro Gln Met 100 105 110 Met Lys His Val Glu Asp Gly Asn Leu Arg Ile Glu Trp Arg Glu Val 115 120 125 Asn Ile Phe Gly Glu Pro Ser Glu Arg Gly Ala Arg Ala Ala Tyr Ala 130 135 140 Ala Gly Leu Gln Asp Ala Tyr Leu Glu Tyr His Asn Ala Leu Phe Ala 145 150 155 160 Asn Gly Glu Lys Pro Ser Glu Asp Leu Leu Ser Glu Glu Gly Leu Ile 165 170 175 Lys Leu Ala Gly Asp Leu Gly Leu Asp Glu Ser Lys Phe Thr Ala Asp 180 185 190 Phe Gln Ser Pro Glu Thr Ala Val Ala Ile Ala Gln His Gln Gln Leu 195 200 205 Gly Ile Asp Leu Gly Ala Tyr Ser Thr Pro Ala Phe Leu Leu Gly Gly 210 215 220 Gln Pro Ile Met Gly Ala Gln Pro Ala Ser Val Phe Glu Ala Ala Phe 225 230 235 240 Glu Gln Ala Leu Ala Ala Lys Glu 245 <210> 183 <211> 1552 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1522) <223> RXA01693 <400> 183 aggagactgg ctggattatt ggctggtttt cttgggaaat cgtcatgggc attaatccta 60 gtcccaacaa ttgccagaac ccgaacacta ggcttgaacc atg aat act gca cct 115 Met Asn Thr Ala Pro 1 5 ttc aaa ctc gaa gct gac ttc gca tca gcc ctg ccc acc atg gca gcc 163 Phe Lys Leu Glu Ala Asp Phe Ala Ser Ala Leu Pro Thr Met Ala Ala 10 15 20 ccc tgg caa ggt gag gaa gcc ccc aac cct gag ctc gtg att tta aat 211 Pro Trp Gln Gly Glu Glu Ala Pro Asn Pro Glu Leu Val Ile Leu Asn 25 30 35 gac gac ctc gcc tac agc ctc ggg ctt gat ccg aca tgg ctt cgc aca 259 Asp Asp Leu Ala Tyr Ser Leu Gly Leu Asp Pro Thr Trp Leu Arg Thr 40 45 50 cct gag ggc gtt caa ttt ctt ctc gga ctc aac ccc gag ccc tta aca 307 Pro Glu Gly Val Gln Phe Leu Leu Gly Leu Asn Pro Glu Pro Leu Thr 55 60 65 aaa gca gtt gcg cag gcc tat tcc ggc cac caa ttc gga cag ttt gtg 355 Lys Ala Val Ala Gln Ala Tyr Ser Gly His Gln Phe Gly Gln Phe Val 70 75 80 85 gca agc ctt ggt gat ggc cga gcg ctt ctt ctc ggc gaa gcc cgc tca 403 Ala Ser Leu Gly Asp Gly Arg Ala Leu Leu Leu Gly Glu Ala Arg Ser 90 95 100 gct gac ggc gta ctg cat gat atc cac ctc aaa gga tct gga cga acc 451 Ala Asp Gly Val Leu His Asp Ile His Leu Lys Gly Ser Gly Arg Thr 105 110 115 caa ttc tcc cga gga gcc gat gga cgc gcc gtc ctt ggc ccc gtc tta 499 Gln Phe Ser Arg Gly Ala Asp Gly Arg Ala Val Leu Gly Pro Val Leu 120 125 130 cgc gaa tac atc atc tcc gaa gcg atg cat gca ctt ggt gtt ccc acc 547 Arg Glu Tyr Ile Ile Ser Glu Ala Met His Ala Leu Gly Val Pro Thr 135 140 145 acc agg tca ctt gca gta att agc acc ggt agg aaa atc caa cga gga 595 Thr Arg Ser Leu Ala Val Ile Ser Thr Gly Arg Lys Ile Gln Arg Gly 150 155 160 165 agc gta gcc cca ggc gca gtc ctt gtt cga gta gca acc agc ctc att 643 Ser Val Ala Pro Gly Ala Val Leu Val Arg Val Ala Thr Ser Leu Ile 170 175 180 cga gtc gga tcc ttc caa tac tcc aac atc tct ggt ggc atc gaa cta 691 Arg Val Gly Ser Phe Gln Tyr Ser Asn Ile Ser Gly Gly Ile Glu Leu 185 190 195 tct caa cac ctg gcg aac tat acg atc acc agg cat ttc cct tcg ttg 739 Ser Gln His Leu Ala Asn Tyr Thr Ile Thr Arg His Phe Pro Ser Leu 200 205 210 gta gct gaa cta tcc gca cca acc ccc gca act tat gta tca ctg ttt 787 Val Ala Glu Leu Ser Ala Pro Thr Pro Ala Thr Tyr Val Ser Leu Phe 215 220 225 aaa gcg att ctt cag cgc caa gca gac acc gtt gga aaa tgg acc agg 835 Lys Ala Ile Leu Gln Arg Gln Ala Asp Thr Val Gly Lys Trp Thr Arg 230 235 240 245 ctg ggt ttc gtt cac gga gcc ctc aac aca gac aac acg ttg ata tcc 883 Leu Gly Phe Val His Gly Ala Leu Asn Thr Asp Asn Thr Leu Ile Ser 250 255 260 gga gaa act gtt gac tac ggc cca tgc gct ttc atg gag cgc tac cgt 931 Gly Glu Thr Val Asp Tyr Gly Pro Cys Ala Phe Met Glu Arg Tyr Arg 265 270 275 ggc gac gcg aaa ttt agc tcc atc gac act tat ggt cgc tac aaa ttt 979 Gly Asp Ala Lys Phe Ser Ser Ile Asp Thr Tyr Gly Arg Tyr Lys Phe 280 285 290 gaa aac caa cct atg atc ctc gga tgg aac atg gcc cgc ctc gta gaa 1027 Glu Asn Gln Pro Met Ile Leu Gly Trp Asn Met Ala Arg Leu Val Glu 295 300 305 acc ctc ctc cca ctc ctg ggc gcc aca cca gac gaa ggc atg aca gca 1075 Thr Leu Leu Pro Leu Leu Gly Ala Thr Pro Asp Glu Gly Met Thr Ala 310 315 320 325 gcc caa gaa gct ctc gta gaa ttc gat gac ctc tgc gaa caa gca atc 1123 Ala Gln Glu Ala Leu Val Glu Phe Asp Asp Leu Cys Glu Gln Ala Ile 330 335 340 cga aaa gaa ttc gcc act gca ctg ggc ctt gac gag tca gac acc ggc 1171 Arg Lys Glu Phe Ala Thr Ala Leu Gly Leu Asp Glu Ser Asp Thr Gly 345 350 355 acg gta gag cag ttc cgt gaa ctg ctc tac ctc cat aac ccc gac atc 1219 Thr Val Glu Gln Phe Arg Glu Leu Leu Tyr Leu His Asn Pro Asp Ile 360 365 370 acc acg ctg ctg cgc gca ctc acc gac aac acc gca cca ccg agt ggc 1267 Thr Thr Leu Leu Arg Ala Leu Thr Asp Asn Thr Ala Pro Pro Ser Gly 375 380 385 ttt gaa gca ttc gtt cac gac tgg aaa acc caa gac cca gat atc gaa 1315 Phe Glu Ala Phe Val His Asp Trp Lys Thr Gln Asp Pro Asp Ile Glu 390 395 400 405 gca atg cga gca gta aat cca ctt ttc att cca cgc aat cac ctc gtg 1363 Ala Met Arg Ala Val Asn Pro Leu Phe Ile Pro Arg Asn His Leu Val 410 415 420 gaa gct gct ctc gca gac gca gtt gaa ggg aat cta gaa aag ttc cac 1411 Glu Ala Ala Leu Ala Asp Ala Val Glu Gly Asn Leu Glu Lys Phe His 425 430 435 gaa ctc ctc gct gct gtc acc aat cct ttt gat cca act gcg ggc ccc 1459 Glu Leu Leu Ala Ala Val Thr Asn Pro Phe Asp Pro Thr Ala Gly Pro 440 445 450 gat gaa cta cgc ctg cca agc gaa gaa gga ttt gaa gaa gac tac atg 1507 Asp Glu Leu Arg Leu Pro Ser Glu Glu Gly Phe Glu Glu Asp Tyr Met 455 460 465 acc ttc tgc ggt acc taggacagat ggtggggcag acgtcggggt 1552 Thr Phe Cys Gly Thr 470 <210> 184 <211> 474 <212> PRT <213> Corynebacterium glutamicum <400> 184 Met Asn Thr Ala Pro Phe Lys Leu Glu Ala Asp Phe Ala Ser Ala Leu 1 5 10 15 Pro Thr Met Ala Ala Pro Trp Gln Gly Glu Glu Ala Pro Asn Pro Glu 20 25 30 Leu Val Ile Leu Asn Asp Asp Leu Ala Tyr Ser Leu Gly Leu Asp Pro 35 40 45 Thr Trp Leu Arg Thr Pro Glu Gly Val Gln Phe Leu Leu Gly Leu Asn 50 55 60 Pro Glu Pro Leu Thr Lys Ala Val Ala Gln Ala Tyr Ser Gly His Gln 65 70 75 80 Phe Gly Gln Phe Val Ala Ser Leu Gly Asp Gly Arg Ala Leu Leu Leu 85 90 95 Gly Glu Ala Arg Ser Ala Asp Gly Val Leu His Asp Ile His Leu Lys 100 105 110 Gly Ser Gly Arg Thr Gln Phe Ser Arg Gly Ala Asp Gly Arg Ala Val 115 120 125 Leu Gly Pro Val Leu Arg Glu Tyr Ile Ile Ser Glu Ala Met His Ala 130 135 140 Leu Gly Val Pro Thr Thr Arg Ser Leu Ala Val Ile Ser Thr Gly Arg 145 150 155 160 Lys Ile Gln Arg Gly Ser Val Ala Pro Gly Ala Val Leu Val Arg Val 165 170 175 Ala Thr Ser Leu Ile Arg Val Gly Ser Phe Gln Tyr Ser Asn Ile Ser 180 185 190 Gly Gly Ile Glu Leu Ser Gln His Leu Ala Asn Tyr Thr Ile Thr Arg 195 200 205 His Phe Pro Ser Leu Val Ala Glu Leu Ser Ala Pro Thr Pro Ala Thr 210 215 220 Tyr Val Ser Leu Phe Lys Ala Ile Leu Gln Arg Gln Ala Asp Thr Val 225 230 235 240 Gly Lys Trp Thr Arg Leu Gly Phe Val His Gly Ala Leu Asn Thr Asp 245 250 255 Asn Thr Leu Ile Ser Gly Glu Thr Val Asp Tyr Gly Pro Cys Ala Phe 260 265 270 Met Glu Arg Tyr Arg Gly Asp Ala Lys Phe Ser Ser Ile Asp Thr Tyr 275 280 285 Gly Arg Tyr Lys Phe Glu Asn Gln Pro Met Ile Leu Gly Trp Asn Met 290 295 300 Ala Arg Leu Val Glu Thr Leu Leu Pro Leu Leu Gly Ala Thr Pro Asp 305 310 315 320 Glu Gly Met Thr Ala Ala Gln Glu Ala Leu Val Glu Phe Asp Asp Leu 325 330 335 Cys Glu Gln Ala Ile Arg Lys Glu Phe Ala Thr Ala Leu Gly Leu Asp 340 345 350 Glu Ser Asp Thr Gly Thr Val Glu Gln Phe Arg Glu Leu Leu Tyr Leu 355 360 365 His Asn Pro Asp Ile Thr Thr Leu Leu Arg Ala Leu Thr Asp Asn Thr 370 375 380 Ala Pro Pro Ser Gly Phe Glu Ala Phe Val His Asp Trp Lys Thr Gln 385 390 395 400 Asp Pro Asp Ile Glu Ala Met Arg Ala Val Asn Pro Leu Phe Ile Pro 405 410 415 Arg Asn His Leu Val Glu Ala Ala Leu Ala Asp Ala Val Glu Gly Asn 420 425 430 Leu Glu Lys Phe His Glu Leu Leu Ala Ala Val Thr Asn Pro Phe Asp 435 440 445 Pro Thr Ala Gly Pro Asp Glu Leu Arg Leu Pro Ser Glu Glu Gly Phe 450 455 460 Glu Glu Asp Tyr Met Thr Phe Cys Gly Thr 465 470 <210> 185 <211> 928 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(898) <223> RXA01741 <400> 185 gcatctctgg cttttcctgc atgacagatg attgtaactg tgatgaaata aggccagatg 60 aagtaactgt gtcgattaag ttttggggga aatttttcag atg aca cac atc gct 115 Met Thr His Ile Ala 1 5 tta gcc aac tct gcc caa gtt ctg atc cgc ccg gat tct gcg att caa 163 Leu Ala Asn Ser Ala Gln Val Leu Ile Arg Pro Asp Ser Ala Ile Gln 10 15 20 ttc ggc atc gac gcc acc cgc gct ggc gtc tta aat atc gat cca tcg 211 Phe Gly Ile Asp Ala Thr Arg Ala Gly Val Leu Asn Ile Asp Pro Ser 25 30 35 ctg tcg tcg cga gtc gtc ccg gtg ctg cgg aat ctg cgg acc gcc cga 259 Leu Ser Ser Arg Val Val Pro Val Leu Arg Asn Leu Arg Thr Ala Arg 40 45 50 ccg atc gtt gat gtc atc gcc gac ctc acg act gca ggc ctc gca ccc 307 Pro Ile Val Asp Val Ile Ala Asp Leu Thr Thr Ala Gly Leu Ala Pro 55 60 65 acc gct gcg agc agt ttg ctc gag gac ctt tta gaa ttc ggt gtg gtc 355 Thr Ala Ala Ser Ser Leu Leu Glu Asp Leu Leu Glu Phe Gly Val Val 70 75 80 85 cgc gaa tcg gcg gcg gcg cag gtg ttg ctg ttc ggg gac ggt tcg ctt 403 Arg Glu Ser Ala Ala Ala Gln Val Leu Leu Phe Gly Asp Gly Ser Leu 90 95 100 gtc gac gtc acc tcc ttc ctt ttg gaa acc tcc ggc ttt gtt ccc aga 451 Val Asp Val Thr Ser Phe Leu Leu Glu Thr Ser Gly Phe Val Pro Arg 105 110 115 ccc cag atc atc gat gag tcg cct cga gag ttt ttc gag ctt ccc tcc 499 Pro Gln Ile Ile Asp Glu Ser Pro Arg Glu Phe Phe Glu Leu Pro Ser 120 125 130 agc cac att ttg gtt ctc aac aag ctc gca cat tcc caa cgt cta tcc 547 Ser His Ile Leu Val Leu Asn Lys Leu Ala His Ser Gln Arg Leu Ser 135 140 145 ccg ctg ctt cac aaa tat gcg ccg acg tat ctg tgc gcc gcg atc gtc 595 Pro Leu Leu His Lys Tyr Ala Pro Thr Tyr Leu Cys Ala Ala Ile Val 150 155 160 165 gat aat cgt ggc atc atc ggc ccg ggc cgg aga tca cga tcg ggg ccg 643 Asp Asn Arg Gly Ile Ile Gly Pro Gly Arg Arg Ser Arg Ser Gly Pro 170 175 180 tgt ttg atg tgt gtg gat ctg cat cgc tgc gat atc gat ccg cat tgg 691 Cys Leu Met Cys Val Asp Leu His Arg Cys Asp Ile Asp Pro His Trp 185 190 195 ctc tct att atc aat cag caa ccc aac ggt ccc acc ttt cct gat ccc 739 Leu Ser Ile Ile Asn Gln Gln Pro Asn Gly Pro Thr Phe Pro Asp Pro 200 205 210 gtc acg gag atg gcg acg gct gcc cga ctc gtc gcc tgg gtc act gcc 787 Val Thr Glu Met Ala Thr Ala Ala Arg Leu Val Ala Trp Val Thr Ala 215 220 225 gat aca tgg ttg ccc ggc gtt gtg gag gaa gta aac ccc cac gat cga 835 Asp Thr Trp Leu Pro Gly Val Val Glu Glu Val Asn Pro His Asp Arg 230 235 240 245 aca aac tcg gta cgc acc ctc cct gtg cat cca aaa tgt ccg atg tgt 883 Thr Asn Ser Val Arg Thr Leu Pro Val His Pro Lys Cys Pro Met Cys 250 255 260 tgg agt tta ggt tcc taaagtgctc ccaaaatcgc gagcacgtca 928 Trp Ser Leu Gly Ser 265 <210> 186 <211> 266 <212> PRT <213> Corynebacterium glutamicum <400> 186 Met Thr His Ile Ala Leu Ala Asn Ser Ala Gln Val Leu Ile Arg Pro 1 5 10 15 Asp Ser Ala Ile Gln Phe Gly Ile Asp Ala Thr Arg Ala Gly Val Leu 20 25 30 Asn Ile Asp Pro Ser Leu Ser Ser Arg Val Val Pro Val Leu Arg Asn 35 40 45 Leu Arg Thr Ala Arg Pro Ile Val Asp Val Ile Ala Asp Leu Thr Thr 50 55 60 Ala Gly Leu Ala Pro Thr Ala Ala Ser Ser Leu Leu Glu Asp Leu Leu 65 70 75 80 Glu Phe Gly Val Val Arg Glu Ser Ala Ala Ala Gln Val Leu Leu Phe 85 90 95 Gly Asp Gly Ser Leu Val Asp Val Thr Ser Phe Leu Leu Glu Thr Ser 100 105 110 Gly Phe Val Pro Arg Pro Gln Ile Ile Asp Glu Ser Pro Arg Glu Phe 115 120 125 Phe Glu Leu Pro Ser Ser His Ile Leu Val Leu Asn Lys Leu Ala His 130 135 140 Ser Gln Arg Leu Ser Pro Leu Leu His Lys Tyr Ala Pro Thr Tyr Leu 145 150 155 160 Cys Ala Ala Ile Val Asp Asn Arg Gly Ile Ile Gly Pro Gly Arg Arg 165 170 175 Ser Arg Ser Gly Pro Cys Leu Met Cys Val Asp Leu His Arg Cys Asp 180 185 190 Ile Asp Pro His Trp Leu Ser Ile Ile Asn Gln Gln Pro Asn Gly Pro 195 200 205 Thr Phe Pro Asp Pro Val Thr Glu Met Ala Thr Ala Ala Arg Leu Val 210 215 220 Ala Trp Val Thr Ala Asp Thr Trp Leu Pro Gly Val Val Glu Glu Val 225 230 235 240 Asn Pro His Asp Arg Thr Asn Ser Val Arg Thr Leu Pro Val His Pro 245 250 255 Lys Cys Pro Met Cys Trp Ser Leu Gly Ser 260 265 <210> 187 <211> 1747 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1717) <223> RXA01749 <400> 187 ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60 taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg agc ttc ctt gta 115 Val Ser Phe Leu Val 1 5 gaa aat caa tta ctc gcg ttg gtt gtc atc atg acg gtc gga cta ttg 163 Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met Thr Val Gly Leu Leu 10 15 20 ctc ggc cgc atc aaa att ttc ggg ttc cgt ctc ggc gtc gcc gct gta 211 Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu Gly Val Ala Ala Val 25 30 35 ctg ttt gta ggt cta gcg cta tcc acc att gag ccg gat att tcc gtc 259 Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu Pro Asp Ile Ser Val 40 45 50 cca tcc ctc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg atc 307 Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr Ile 55 60 65 ggt ctg gaa gcc ggc cct gga ttc ttc acc tcc atg aaa acc act ggt 355 Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser Met Lys Thr Thr Gly 70 75 80 85 ctg cgc aac aac gca ctg acc ttg ggc gcc atc atc gcc acc acg gca 403 Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile Ile Ala Thr Thr Ala 90 95 100 ctc gca tgg gca ctc atc aca gtt ttg aac atc gat gcc gcc tcc ggc 451 Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile Asp Ala Ala Ser Gly 105 110 115 gcc ggc atg ctc acc ggc gcg ctc acc aac acc cca gcc atg gcc gca 499 Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Ala Met Ala Ala 120 125 130 gtt gtt gac gca ctt cct tcg ctt atc gac gac acc ggc cag ctt cac 547 Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp Thr Gly Gln Leu His 135 140 145 ctc atc gcc gag ctg ccc gtc gtc gca tat tcc ttg gca tac ccc ctc 595 Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser Leu Ala Tyr Pro Leu 150 155 160 165 ggt gtg ctc atc gtt att ctc tcc atc gcc atc ttc agc tct gtg ttc 643 Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile Phe Ser Ser Val Phe 170 175 180 aaa gtc gac cac aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691 Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala Gly Val Ala Val Gln 185 190 195 gaa ctc aaa ggc cgt cgc atc cgc gtc acc gtc gct gat ctt cca gcc 739 Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val Ala Asp Leu Pro Ala 200 205 210 ctg gag aac atc cca gag ctg ctc aac ctc cac gtc att gtg tcc cga 787 Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His Val Ile Val Ser Arg 215 220 225 gtg gaa cga gac ggt gag caa ttc atc ccg ctt tat ggc gaa cac gca 835 Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu Tyr Gly Glu His Ala 230 235 240 245 cgc atc ggc gat gtc tta aca gtg gtg ggt gcc gat gaa gaa ctc aac 883 Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala Asp Glu Glu Leu Asn 250 255 260 cgc gcg gaa aaa gcc atc ggt gaa ctc att gac ggc gac ccc tac agc 931 Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp Gly Asp Pro Tyr Ser 265 270 275 aat gtg gaa ctt gat tac cga cgc atc ttc gtc tca aac aca gca gtc 979 Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val Ser Asn Thr Ala Val 280 285 290 gtg ggc act ccc cta tcc aag ctc cag cca ctg ttt aaa gac atg ctg 1027 Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu 295 300 305 atc acc cgc atc agg cgc ggc gac aca gat ttg gtg gcc tcc tcc gac 1075 Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu Val Ala Ser Ser Asp 310 315 320 325 atg act ttg cag ctc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123 Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Ala Pro Ala Glu 330 335 340 aaa ctc cgc gaa gca acc caa ttg ctc ggc gat tcc tac aag aaa ctc 1171 Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu 345 350 355 tcc gat ttc aac ctg ctc cca ctc gct gcc ggc ctc atg atc ggt gtg 1219 Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly Leu Met Ile Gly Val 360 365 370 ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga agc tcc ctg aaa 1267 Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys 375 380 385 ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg ctc ggc atg 1315 Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala Leu Leu Leu Gly Met 390 395 400 405 atc aat cgc aca ggc aag ttc gtc tgg caa atc ccc tac gga gca aac 1363 Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile Pro Tyr Gly Ala Asn 410 415 420 ctt gcc ctt cgc caa ctg ggc atc aca cta ttt ttg gct gcc atc ggt 1411 Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe Leu Ala Ala Ile Gly 425 430 435 acc tca gcg ggc gca gga ttt cga tca gcg atc agc gac ccc caa tca 1459 Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile Ser Asp Pro Gln Ser 440 445 450 ctc acc atc atc ggc ttc ggt gcg ctg ctc act ttg ttc atc tcc atc 1507 Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr Leu Phe Ile Ser Ile 455 460 465 acg gtg ctg ttc gtt ggc cac aaa ctg atg aaa atc ccc ttc ggt gaa 1555 Thr Val Leu Phe Val Gly His Lys Leu Met Lys Ile Pro Phe Gly Glu 470 475 480 485 acc gct ggc atc ctc gcc ggt acg caa acc cac cct gct gtg ctg agt 1603 Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His Pro Ala Val Leu Ser 490 495 500 tat gtg tca gat gcc tcc cgc aac gag ctc cct gcc atg ggt tat acc 1651 Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro Ala Met Gly Tyr Thr 505 510 515 tct gtg tat ccg ctg gcg atg atc gca aag atc ctg gcc gcc caa acg 1699 Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile Leu Ala Ala Gln Thr 520 525 530 ttg ttg ttc cta ctt atc tagcattgac cccttaagcg cagaaggcga 1747 Leu Leu Phe Leu Leu Ile 535 <210> 188 <211> 539 <212> PRT <213> Corynebacterium glutamicum <400> 188 Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met 1 5 10 15 Thr Val Gly Leu Leu Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu 20 25 30 Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu 35 40 45 Pro Asp Ile Ser Val Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu 50 55 60 Phe Val Tyr Thr Ile Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser 65 70 75 80 Met Lys Thr Thr Gly Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile 85 90 95 Ile Ala Thr Thr Ala Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile 100 105 110 Asp Ala Ala Ser Gly Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr 115 120 125 Pro Ala Met Ala Ala Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp 130 135 140 Thr Gly Gln Leu His Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser 145 150 155 160 Leu Ala Tyr Pro Leu Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile 165 170 175 Phe Ser Ser Val Phe Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala 180 185 190 Gly Val Ala Val Gln Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val 195 200 205 Ala Asp Leu Pro Ala Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His 210 215 220 Val Ile Val Ser Arg Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu 225 230 235 240 Tyr Gly Glu His Ala Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala 245 250 255 Asp Glu Glu Leu Asn Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp 260 265 270 Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val 275 280 285 Ser Asn Thr Ala Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu 290 295 300 Phe Lys Asp Met Leu Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu 305 310 315 320 Val Ala Ser Ser Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val 325 330 335 Val Ala Pro Ala Glu Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp 340 345 350 Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly 355 360 365 Leu Met Ile Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly 370 375 380 Gly Ser Ser Leu Lys Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala 385 390 395 400 Leu Leu Leu Gly Met Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile 405 410 415 Pro Tyr Gly Ala Asn Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe 420 425 430 Leu Ala Ala Ile Gly Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile 435 440 445 Ser Asp Pro Gln Ser Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr 450 455 460 Leu Phe Ile Ser Ile Thr Val Leu Phe Val Gly His Lys Leu Met Lys 465 470 475 480 Ile Pro Phe Gly Glu Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His 485 490 495 Pro Ala Val Leu Ser Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro 500 505 510 Ala Met Gly Tyr Thr Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile 515 520 525 Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu Ile 530 535 <210> 189 <211> 2071 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2041) <223> RXA01754 <400> 189 tgtggctgaa gacaagaatg aatagcattc atctcgtcga atttcatgta gaaatttgtc 60 cccctttttt ttgatgtgaa agttgaatcg gtaagctcct gtg aaa att aaa tcc 115 Val Lys Ile Lys Ser 1 5 gta ttt ttg agc acc gct tta agc gct tcc tta ctg ctc ggg atc acc 163 Val Phe Leu Ser Thr Ala Leu Ser Ala Ser Leu Leu Leu Gly Ile Thr 10 15 20 cca ccc gtg ctg gga gca acg atc aac ccc agt ttg cct ctt tct gcg 211 Pro Pro Val Leu Gly Ala Thr Ile Asn Pro Ser Leu Pro Leu Ser Ala 25 30 35 ttg agc tcc tcg gac gat atc gcc gta ccc aac ttc gcc aaa gaa tta 259 Leu Ser Ser Ser Asp Asp Ile Ala Val Pro Asn Phe Ala Lys Glu Leu 40 45 50 ccg tta gct ttt gat gta cca gca ggc act gtt ccc caa agc ttg agt 307 Pro Leu Ala Phe Asp Val Pro Ala Gly Thr Val Pro Gln Ser Leu Ser 55 60 65 gga acg ctg cag att cct gcc gag ttt tct ggc ggc gtc gtg gag ttt 355 Gly Thr Leu Gln Ile Pro Ala Glu Phe Ser Gly Gly Val Val Glu Phe 70 75 80 85 tat gac ggt gac cgg ctc ttt cac acc ctg cgc cta gaa gtt aat gat 403 Tyr Asp Gly Asp Arg Leu Phe His Thr Leu Arg Leu Glu Val Asn Asp 90 95 100 tcc cga gca cac att gag gtt ccg ctg caa agc gtt cct gtc gaa gac 451 Ser Arg Ala His Ile Glu Val Pro Leu Gln Ser Val Pro Val Glu Asp 105 110 115 ggc cgc gcc acc ttt tgg ttg cgc gcc atg ttg gat cct gta aac aac 499 Gly Arg Ala Thr Phe Trp Leu Arg Ala Met Leu Asp Pro Val Asn Asn 120 125 130 cag tgg tgc tac gag gag cag gaa gtc cgc ttc tta gac gga aac gtc 547 Gln Trp Cys Tyr Glu Glu Gln Glu Val Arg Phe Leu Asp Gly Asn Val 135 140 145 acc ttt gaa ggg gcg acg att aac cca gct gtg gtg gct gat tac ttc 595 Thr Phe Glu Gly Ala Thr Ile Asn Pro Ala Val Val Ala Asp Tyr Phe 150 155 160 165 ccg tca gtg ctg cgc gcg ttg aca att tac gtc ccg gaa aac ccc tct 643 Pro Ser Val Leu Arg Ala Leu Thr Ile Tyr Val Pro Glu Asn Pro Ser 170 175 180 gag gca gta caa gaa gcc acg tta gag gtt gcg acc tcc ctg gat tcg 691 Glu Ala Val Gln Glu Ala Thr Leu Glu Val Ala Thr Ser Leu Asp Ser 185 190 195 gtg tac cga aga tca ggt ctg gat gtc aac gta gaa acg ctt cca acc 739 Val Tyr Arg Arg Ser Gly Leu Asp Val Asn Val Glu Thr Leu Pro Thr 200 205 210 ggc acc gat gct cct cct aca cgt cct caa gat ttt gaa cgc cag att 787 Gly Thr Asp Ala Pro Pro Thr Arg Pro Gln Asp Phe Glu Arg Gln Ile 215 220 225 gtg ctg gtt gac gag gca aca gaa agt aac acg caa aaa acc gaa ttg 835 Val Leu Val Asp Glu Ala Thr Glu Ser Asn Thr Gln Lys Thr Glu Leu 230 235 240 245 gtc aat ccc ggc caa gac aat gca ttc ttg cgc ctg aac ggc aac gcc 883 Val Asn Pro Gly Gln Asp Asn Ala Phe Leu Arg Leu Asn Gly Asn Ala 250 255 260 gac gag ctt tac gat caa gcg cgc ttg ctt acc gac gca acc ctg cca 931 Asp Glu Leu Tyr Asp Gln Ala Arg Leu Leu Thr Asp Ala Thr Leu Pro 265 270 275 ctt gcc gta gac acc gaa gta acg gcc tca ggt ttt ggt gat gtg ccc 979 Leu Ala Val Asp Thr Glu Val Thr Ala Ser Gly Phe Gly Asp Val Pro 280 285 290 aac ctt tct aca gat gtg gcc acc ctc caa gaa ctg ggt atc acg cag 1027 Asn Leu Ser Thr Asp Val Ala Thr Leu Gln Glu Leu Gly Ile Thr Gln 295 300 305 ctc acc tct gaa tca gtt gcg cgc aca agc gtc acc ttg ggc att gaa 1075 Leu Thr Ser Glu Ser Val Ala Arg Thr Ser Val Thr Leu Gly Ile Glu 310 315 320 325 cgc tcc cgc ctg cgg acc tac tcg cag tcc atg gac ctg cac ata acg 1123 Arg Ser Arg Leu Arg Thr Tyr Ser Gln Ser Met Asp Leu His Ile Thr 330 335 340 gga acc tac acc cca ttg cca ccc caa aat gca gga cag atc acg ttc 1171 Gly Thr Tyr Thr Pro Leu Pro Pro Gln Asn Ala Gly Gln Ile Thr Phe 345 350 355 tcc att ggt gac acc gtg ttg gac tcc ttg acc acc gat gac act ggc 1219 Ser Ile Gly Asp Thr Val Leu Asp Ser Leu Thr Thr Asp Asp Thr Gly 360 365 370 atc att gac cgt gag ttc aac gtt cct gga gac ttg gtc aac cgc tac 1267 Ile Ile Asp Arg Glu Phe Asn Val Pro Gly Asp Leu Val Asn Arg Tyr 375 380 385 acg gcg atc gtc gtg gaa ttc acc agc acc ggc gac gtt aat tgt ggg 1315 Thr Ala Ile Val Val Glu Phe Thr Ser Thr Gly Asp Val Asn Cys Gly 390 395 400 405 gtc acc cag ccc gta ggc ctc aac att gat tcc gac agc ctt gtc acc 1363 Val Thr Gln Pro Val Gly Leu Asn Ile Asp Ser Asp Ser Leu Val Thr 410 415 420 tcc caa cat tca gat gtt cct gta ctc aac ggc ttc cgg tcc cta ccg 1411 Ser Gln His Ser Asp Val Pro Val Leu Asn Gly Phe Arg Ser Leu Pro 425 430 435 cag tcc ttc caa cct cgt gtg gac gtg gcg ttt gct gat ccc agc gtg 1459 Gln Ser Phe Gln Pro Arg Val Asp Val Ala Phe Ala Asp Pro Ser Val 440 445 450 cag gaa ctc tcc cgc gct gtc agc gta gtg ttg gga att caa tct atg 1507 Gln Glu Leu Ser Arg Ala Val Ser Val Val Leu Gly Ile Gln Ser Met 455 460 465 agc tcc cag cgc atc cgc cca cac ctg gtt aac tgg gat gaa gcc gta 1555 Ser Ser Gln Arg Ile Arg Pro His Leu Val Asn Trp Asp Glu Ala Val 470 475 480 485 gcc agc gag cgc cca aca att ttc att gat gct gcg ggc gca aag act 1603 Ala Ser Glu Arg Pro Thr Ile Phe Ile Asp Ala Ala Gly Ala Lys Thr 490 495 500 gat caa gtg cca agc tac ctc gcc caa caa ggc caa acc cta gag atc 1651 Asp Gln Val Pro Ser Tyr Leu Ala Gln Gln Gly Gln Thr Leu Glu Ile 505 510 515 acc agc aag aac gac caa aat gcg gac ggc gaa caa ctc acc cga tcc 1699 Thr Ser Lys Asn Asp Gln Asn Ala Asp Gly Glu Gln Leu Thr Arg Ser 520 525 530 ctg caa acc aac gct gcg ctt gtt gtc ggt tcc att cag gcc gtg tgg 1747 Leu Gln Thr Asn Ala Ala Leu Val Val Gly Ser Ile Gln Ala Val Trp 535 540 545 gat gcc gat aag aag cgc acg gtg att gtg gca agt tcc cag gac aac 1795 Asp Ala Asp Lys Lys Arg Thr Val Ile Val Ala Ser Ser Gln Asp Asn 550 555 560 565 ccc gcc gat ttg gat gcc ttg att tcg tgg atg gga gaa gac cgc gaa 1843 Pro Ala Asp Leu Asp Ala Leu Ile Ser Trp Met Gly Glu Asp Arg Glu 570 575 580 cgc tgg agt gat ctc aac ggc gac ctg att gtc aaa gtc cga gac cgc 1891 Arg Trp Ser Asp Leu Asn Gly Asp Leu Ile Val Lys Val Arg Asp Arg 585 590 595 gaa cct gtg caa ttg acc acc gtg gaa gcc cca gat cag cct ggt cga 1939 Glu Pro Val Gln Leu Thr Thr Val Glu Ala Pro Asp Gln Pro Gly Arg 600 605 610 tcg gcc aca gcc ttt att gcg atc ggc gtc agc ctt gtg gtc att gcc 1987 Ser Ala Thr Ala Phe Ile Ala Ile Gly Val Ser Leu Val Val Ile Ala 615 620 625 ctg att gtc gca gcc gtg gtg tca gtg tcc agg cgt tcg caa aaa gga 2035 Leu Ile Val Ala Ala Val Val Ser Val Ser Arg Arg Ser Gln Lys Gly 630 635 640 645 tac aaa tgatttcttc tttacccagt agaacgcagg 2071 Tyr Lys <210> 190 <211> 647 <212> PRT <213> Corynebacterium glutamicum <400> 190 Val Lys Ile Lys Ser Val Phe Leu Ser Thr Ala Leu Ser Ala Ser Leu 1 5 10 15 Leu Leu Gly Ile Thr Pro Pro Val Leu Gly Ala Thr Ile Asn Pro Ser 20 25 30 Leu Pro Leu Ser Ala Leu Ser Ser Ser Asp Asp Ile Ala Val Pro Asn 35 40 45 Phe Ala Lys Glu Leu Pro Leu Ala Phe Asp Val Pro Ala Gly Thr Val 50 55 60 Pro Gln Ser Leu Ser Gly Thr Leu Gln Ile Pro Ala Glu Phe Ser Gly 65 70 75 80 Gly Val Val Glu Phe Tyr Asp Gly Asp Arg Leu Phe His Thr Leu Arg 85 90 95 Leu Glu Val Asn Asp Ser Arg Ala His Ile Glu Val Pro Leu Gln Ser 100 105 110 Val Pro Val Glu Asp Gly Arg Ala Thr Phe Trp Leu Arg Ala Met Leu 115 120 125 Asp Pro Val Asn Asn Gln Trp Cys Tyr Glu Glu Gln Glu Val Arg Phe 130 135 140 Leu Asp Gly Asn Val Thr Phe Glu Gly Ala Thr Ile Asn Pro Ala Val 145 150 155 160 Val Ala Asp Tyr Phe Pro Ser Val Leu Arg Ala Leu Thr Ile Tyr Val 165 170 175 Pro Glu Asn Pro Ser Glu Ala Val Gln Glu Ala Thr Leu Glu Val Ala 180 185 190 Thr Ser Leu Asp Ser Val Tyr Arg Arg Ser Gly Leu Asp Val Asn Val 195 200 205 Glu Thr Leu Pro Thr Gly Thr Asp Ala Pro Pro Thr Arg Pro Gln Asp 210 215 220 Phe Glu Arg Gln Ile Val Leu Val Asp Glu Ala Thr Glu Ser Asn Thr 225 230 235 240 Gln Lys Thr Glu Leu Val Asn Pro Gly Gln Asp Asn Ala Phe Leu Arg 245 250 255 Leu Asn Gly Asn Ala Asp Glu Leu Tyr Asp Gln Ala Arg Leu Leu Thr 260 265 270 Asp Ala Thr Leu Pro Leu Ala Val Asp Thr Glu Val Thr Ala Ser Gly 275 280 285 Phe Gly Asp Val Pro Asn Leu Ser Thr Asp Val Ala Thr Leu Gln Glu 290 295 300 Leu Gly Ile Thr Gln Leu Thr Ser Glu Ser Val Ala Arg Thr Ser Val 305 310 315 320 Thr Leu Gly Ile Glu Arg Ser Arg Leu Arg Thr Tyr Ser Gln Ser Met 325 330 335 Asp Leu His Ile Thr Gly Thr Tyr Thr Pro Leu Pro Pro Gln Asn Ala 340 345 350 Gly Gln Ile Thr Phe Ser Ile Gly Asp Thr Val Leu Asp Ser Leu Thr 355 360 365 Thr Asp Asp Thr Gly Ile Ile Asp Arg Glu Phe Asn Val Pro Gly Asp 370 375 380 Leu Val Asn Arg Tyr Thr Ala Ile Val Val Glu Phe Thr Ser Thr Gly 385 390 395 400 Asp Val Asn Cys Gly Val Thr Gln Pro Val Gly Leu Asn Ile Asp Ser 405 410 415 Asp Ser Leu Val Thr Ser Gln His Ser Asp Val Pro Val Leu Asn Gly 420 425 430 Phe Arg Ser Leu Pro Gln Ser Phe Gln Pro Arg Val Asp Val Ala Phe 435 440 445 Ala Asp Pro Ser Val Gln Glu Leu Ser Arg Ala Val Ser Val Val Leu 450 455 460 Gly Ile Gln Ser Met Ser Ser Gln Arg Ile Arg Pro His Leu Val Asn 465 470 475 480 Trp Asp Glu Ala Val Ala Ser Glu Arg Pro Thr Ile Phe Ile Asp Ala 485 490 495 Ala Gly Ala Lys Thr Asp Gln Val Pro Ser Tyr Leu Ala Gln Gln Gly 500 505 510 Gln Thr Leu Glu Ile Thr Ser Lys Asn Asp Gln Asn Ala Asp Gly Glu 515 520 525 Gln Leu Thr Arg Ser Leu Gln Thr Asn Ala Ala Leu Val Val Gly Ser 530 535 540 Ile Gln Ala Val Trp Asp Ala Asp Lys Lys Arg Thr Val Ile Val Ala 545 550 555 560 Ser Ser Gln Asp Asn Pro Ala Asp Leu Asp Ala Leu Ile Ser Trp Met 565 570 575 Gly Glu Asp Arg Glu Arg Trp Ser Asp Leu Asn Gly Asp Leu Ile Val 580 585 590 Lys Val Arg Asp Arg Glu Pro Val Gln Leu Thr Thr Val Glu Ala Pro 595 600 605 Asp Gln Pro Gly Arg Ser Ala Thr Ala Phe Ile Ala Ile Gly Val Ser 610 615 620 Leu Val Val Ile Ala Leu Ile Val Ala Ala Val Val Ser Val Ser Arg 625 630 635 640 Arg Ser Gln Lys Gly Tyr Lys 645 <210> 191 <211> 4594 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(4564) <223> RXA01761 <400> 191 ttaaagtttc tatattccat tctaaaataa ctttgaattg gggattaatg aaacttttta 60 agcaattgtt taaaacgaat attgaggggg tggcgggcaa gtg act gcg aca gtt 115 Val Thr Ala Thr Val 1 5 tta gaa ccg caa cct gta cag ctt agt gag cag gac gta gat gct gag 163 Leu Glu Pro Gln Pro Val Gln Leu Ser Glu Gln Asp Val Asp Ala Glu 10 15 20 att gcg cgc atg gag ctt aaa cac aac cga cac aag acg tgg cga cgc 211 Ile Ala Arg Met Glu Leu Lys His Asn Arg His Lys Thr Trp Arg Arg 25 30 35 cga acg atg gct gtt gtc atg acg ctc ttg atc tca gtg ggt ttg agc 259 Arg Thr Met Ala Val Val Met Thr Leu Leu Ile Ser Val Gly Leu Ser 40 45 50 ttt ggt gcg ttt ggt aac aag gaa cgt gaa gct aat gct ttc gcc agc 307 Phe Gly Ala Phe Gly Asn Lys Glu Arg Glu Ala Asn Ala Phe Ala Ser 55 60 65 gct att att gcc cag gtt gtc ggt gct atg ggc gag gtt gcc ttt gaa 355 Ala Ile Ile Ala Gln Val Val Gly Ala Met Gly Glu Val Ala Phe Glu 70 75 80 85 gcg att tgt ccc agt gat ggt gac acc gag atg ctt ctt aag tgc atc 403 Ala Ile Cys Pro Ser Asp Gly Asp Thr Glu Met Leu Leu Lys Cys Ile 90 95 100 acc gag aac tta ggt gaa atg cac att atc gag aag tgt ctc gaa gca 451 Thr Glu Asn Leu Gly Glu Met His Ile Ile Glu Lys Cys Leu Glu Ala 105 110 115 gaa gat gtc ttg aag tgc ttc tac gat gcg aaa aac gaa gag caa cgt 499 Glu Asp Val Leu Lys Cys Phe Tyr Asp Ala Lys Asn Glu Glu Gln Arg 120 125 130 aaa gaa cag aac ctt gat aaa gcc cct gat tac tcc atg tac cgt atg 547 Lys Glu Gln Asn Leu Asp Lys Ala Pro Asp Tyr Ser Met Tyr Arg Met 135 140 145 gcc tct gcg atg gca tcg ttc tat ggc aat ggt cgg gca gct act gcc 595 Ala Ser Ala Met Ala Ser Phe Tyr Gly Asn Gly Arg Ala Ala Thr Ala 150 155 160 165 ggt gta gag gaa ggc gga ccg aac gag ttc ctc gat tct gag gac gcc 643 Gly Val Glu Glu Gly Gly Pro Asn Glu Phe Leu Asp Ser Glu Asp Ala 170 175 180 ggt ctt aag gtg tgg gag ggc att ctc agt aag gcc gcc aac gga ggc 691 Gly Leu Lys Val Trp Glu Gly Ile Leu Ser Lys Ala Ala Asn Gly Gly 185 190 195 aat gtc ctt ggt tat gct gac gcg aaa cac aac gag gac tct ggt tgg 739 Asn Val Leu Gly Tyr Ala Asp Ala Lys His Asn Glu Asp Ser Gly Trp 200 205 210 ttc ttt ggt aat ggt gtt gcc aac aac gag aaa acg tac tcc tat gat 787 Phe Phe Gly Asn Gly Val Ala Asn Asn Glu Lys Thr Tyr Ser Tyr Asp 215 220 225 tct cta gct gat cat gcc ttt caa ggg cct tat cac ttt gca tta ttt 835 Ser Leu Ala Asp His Ala Phe Gln Gly Pro Tyr His Phe Ala Leu Phe 230 235 240 245 ggc gcg aca ctg agt ggc tta ggc ttt gat agc tca aag gcg gag gat 883 Gly Ala Thr Leu Ser Gly Leu Gly Phe Asp Ser Ser Lys Ala Glu Asp 250 255 260 tcg cag act gat ttt gct cag cgt aag ggc atg ggg tac gcg atg atg 931 Ser Gln Thr Asp Phe Ala Gln Arg Lys Gly Met Gly Tyr Ala Met Met 265 270 275 atc gcg tac atc atc tcc gga ggc att gat ctg gtt ttt aac act gtg 979 Ile Ala Tyr Ile Ile Ser Gly Gly Ile Asp Leu Val Phe Asn Thr Val 280 285 290 ctg aat atc ttg agc acc ata aac cca ttt aga ctg ctc gtt gga cca 1027 Leu Asn Ile Leu Ser Thr Ile Asn Pro Phe Arg Leu Leu Val Gly Pro 295 300 305 gta tct cag aat act aac aag aca ttc act gag aat atg gct ggt ggg 1075 Val Ser Gln Asn Thr Asn Lys Thr Phe Thr Glu Asn Met Ala Gly Gly 310 315 320 325 cag acc aca gaa gga aca ccg ttt gaa gga atg act gat ttc ttc ggg 1123 Gln Thr Thr Glu Gly Thr Pro Phe Glu Gly Met Thr Asp Phe Phe Gly 330 335 340 ttg atc tat aac tgg tca gtg act gtg ggc tgg ctc atc gtt att cct 1171 Leu Ile Tyr Asn Trp Ser Val Thr Val Gly Trp Leu Ile Val Ile Pro 345 350 355 gtc tcc att ggt ctg ttt atg atg ggt gcg ttg atg ttt cga cgc atg 1219 Val Ser Ile Gly Leu Phe Met Met Gly Ala Leu Met Phe Arg Arg Met 360 365 370 gac aag gga tca gcg ttt aaa aag gtt gtt atc cgc gtc gtg tac ggt 1267 Asp Lys Gly Ser Ala Phe Lys Lys Val Val Ile Arg Val Val Tyr Gly 375 380 385 gtc gtt ggc ctg cca ctg ctt ggt gtc tct tat acc ggt gcg ctg gat 1315 Val Val Gly Leu Pro Leu Leu Gly Val Ser Tyr Thr Gly Ala Leu Asp 390 395 400 405 tcc ttc ctc gac agc ggt agt tcc aca agt gct gga tca aat gcg aca 1363 Ser Phe Leu Asp Ser Gly Ser Ser Thr Ser Ala Gly Ser Asn Ala Thr 410 415 420 aag att gtg ttg tcc acc tac gtg gat ttc caa tca tgg gca gaa aac 1411 Lys Ile Val Leu Ser Thr Tyr Val Asp Phe Gln Ser Trp Ala Glu Asn 425 430 435 acc cgt atg cgt gtt cct gac aaa gta aca ctg gcg tgg agt ctg gag 1459 Thr Arg Met Arg Val Pro Asp Lys Val Thr Leu Ala Trp Ser Leu Glu 440 445 450 gat cag gcg cca aca ggg cag tcc atg cgg atg gta cgc aat tcg gcg 1507 Asp Gln Ala Pro Thr Gly Gln Ser Met Arg Met Val Arg Asn Ser Ala 455 460 465 ttg gaa att aat gct caa tca aat gag agt ttt act act ttt aag aat 1555 Leu Glu Ile Asn Ala Gln Ser Asn Glu Ser Phe Thr Thr Phe Lys Asn 470 475 480 485 cca ggt tcc atg gat cta ggc tat agc atg gac tgg atg gaa aag atg 1603 Pro Gly Ser Met Asp Leu Gly Tyr Ser Met Asp Trp Met Glu Lys Met 490 495 500 gcg gat cca gcc aat tct ggc acc gat ggg acc tca tca agt tcg gcg 1651 Ala Asp Pro Ala Asn Ser Gly Thr Asp Gly Thr Ser Ser Ser Ser Ala 505 510 515 acg act att ttc cag gga acc atc gcg cta ctg agt cgt tat atc gac 1699 Thr Thr Ile Phe Gln Gly Thr Ile Ala Leu Leu Ser Arg Tyr Ile Asp 520 525 530 aac gac agt atc tcc tct ggc agt ttc gaa acc tct att cga agt gcg 1747 Asn Asp Ser Ile Ser Ser Gly Ser Phe Glu Thr Ser Ile Arg Ser Ala 535 540 545 atg gaa tct ttg acc tcg aaa gag gga agt ggc gaa gct gtt gcc ggt 1795 Met Glu Ser Leu Thr Ser Lys Glu Gly Ser Gly Glu Ala Val Ala Gly 550 555 560 565 ggt gat gta atg gcc tgg gtt act ggt tac aac aca gcc tct ggt ctt 1843 Gly Asp Val Met Ala Trp Val Thr Gly Tyr Asn Thr Ala Ser Gly Leu 570 575 580 aat gag atc act gct gct gaa tta gct gat gcg aac aat cca ttg ctt 1891 Asn Glu Ile Thr Ala Ala Glu Leu Ala Asp Ala Asn Asn Pro Leu Leu 585 590 595 gag gtc agc gac tca gct ggt ctg cag gga cga cct att gac cgc aat 1939 Glu Val Ser Asp Ser Ala Gly Leu Gln Gly Arg Pro Ile Asp Arg Asn 600 605 610 gcg gtg tca ttt aaa tct ggt gat gcg aca gcg tca tgc aac aac tca 1987 Ala Val Ser Phe Lys Ser Gly Asp Ala Thr Ala Ser Cys Asn Asn Ser 615 620 625 gtc gtg aca ggt tct cgt gct gtg gtc ggg gac tac cga agt gac tgc 2035 Val Val Thr Gly Ser Arg Ala Val Val Gly Asp Tyr Arg Ser Asp Cys 630 635 640 645 aat atg tcg ccc ttg acg atg tac aac ttc ctc aac acc tca ttc cat 2083 Asn Met Ser Pro Leu Thr Met Tyr Asn Phe Leu Asn Thr Ser Phe His 650 655 660 cca gct gat gca agt gtc ttt tct acg tcc act tct gcg tca agc tac 2131 Pro Ala Asp Ala Ser Val Phe Ser Thr Ser Thr Ser Ala Ser Ser Tyr 665 670 675 acc cgt gca tcg cat agc gca gtg agt ctt atc ggt tct ggt gcc atg 2179 Thr Arg Ala Ser His Ser Ala Val Ser Leu Ile Gly Ser Gly Ala Met 680 685 690 aac ttt gtg tac tgg ttc tct gca atg tcc ctg atg ggt agc ttc atc 2227 Asn Phe Val Tyr Trp Phe Ser Ala Met Ser Leu Met Gly Ser Phe Ile 695 700 705 gtg atc ggt atc ggt tac gcc ggt gcc atg ctg ttt aat acg att cga 2275 Val Ile Gly Ile Gly Tyr Ala Gly Ala Met Leu Phe Asn Thr Ile Arg 710 715 720 725 cgc acg ctg tcg ctc att ggt gcc gtt cct ttt gct gcg atg ggc ttt 2323 Arg Thr Leu Ser Leu Ile Gly Ala Val Pro Phe Ala Ala Met Gly Phe 730 735 740 att gct ggt gtt gcc aag gtc att gtg tac acc atc gct atg ctc gta 2371 Ile Ala Gly Val Ala Lys Val Ile Val Tyr Thr Ile Ala Met Leu Val 745 750 755 gag gtt atc gga acg atc att ttg tac cag ctc att acc cgg ttc ttg 2419 Glu Val Ile Gly Thr Ile Ile Leu Tyr Gln Leu Ile Thr Arg Phe Leu 760 765 770 atg gct gta cca gca ctc ttt gaa caa cct ttg gct gat tcc tta agt 2467 Met Ala Val Pro Ala Leu Phe Glu Gln Pro Leu Ala Asp Ser Leu Ser 775 780 785 agt aac gag agt gct gag ctg gtt gcc ggt gct ggt atg ggg cta gtc 2515 Ser Asn Glu Ser Ala Glu Leu Val Ala Gly Ala Gly Met Gly Leu Val 790 795 800 805 ggt atg gca cta gct acc tca ggc aac tgg gcg att gcc ggc atg gtg 2563 Gly Met Ala Leu Ala Thr Ser Gly Asn Trp Ala Ile Ala Gly Met Val 810 815 820 atc aca gtg gcc tca tcc atg ggg gtc atc atc ttc acg att att gcg 2611 Ile Thr Val Ala Ser Ser Met Gly Val Ile Ile Phe Thr Ile Ile Ala 825 830 835 atg aag gtg cgc gga tct ttg gta tca ggt gtc gat gaa gcc gtg acc 2659 Met Lys Val Arg Gly Ser Leu Val Ser Gly Val Asp Glu Ala Val Thr 840 845 850 agt gtt att aac cgc ttc ttg gat aca cag gtc tct tct gca ggt gct 2707 Ser Val Ile Asn Arg Phe Leu Asp Thr Gln Val Ser Ser Ala Gly Ala 855 860 865 acc tct ggt gac ggc atg atg cgt cgt gca gcc gca acg ggt ctt ggt 2755 Thr Ser Gly Asp Gly Met Met Arg Arg Ala Ala Ala Thr Gly Leu Gly 870 875 880 885 att ggt gcg aca cat atg gta ctc aac cgt gat ggt gac ggt ggt gga 2803 Ile Gly Ala Thr His Met Val Leu Asn Arg Asp Gly Asp Gly Gly Gly 890 895 900 tct gat tca ggc tct ggt gga tca ggt ggc ggt agc gat tca ggc ttg 2851 Ser Asp Ser Gly Ser Gly Gly Ser Gly Gly Gly Ser Asp Ser Gly Leu 905 910 915 ggt gag aag gct gct ggt ctg gcg aag gtt gtc aca act gtg gct ggt 2899 Gly Glu Lys Ala Ala Gly Leu Ala Lys Val Val Thr Thr Val Ala Gly 920 925 930 gcc gga tta gtc ggt aag tat gct acg gat gcg ctc gat aat tat gca 2947 Ala Gly Leu Val Gly Lys Tyr Ala Thr Asp Ala Leu Asp Asn Tyr Ala 935 940 945 gat ggc gtt atc aac ggc gac ggt gat ggt gcg ttc gca gca ggt ggt 2995 Asp Gly Val Ile Asn Gly Asp Gly Asp Gly Ala Phe Ala Ala Gly Gly 950 955 960 965 gac gct acc gtt gat ggc gac tat gta gca gat gga gat gca att gct 3043 Asp Ala Thr Val Asp Gly Asp Tyr Val Ala Asp Gly Asp Ala Ile Ala 970 975 980 tct gct gat gct aac gct gat ttt gta gac ggt gtt gtt gat ggt gct 3091 Ser Ala Asp Ala Asn Ala Asp Phe Val Asp Gly Val Val Asp Gly Ala 985 990 995 ggt cgc gcg tca ttt agc aat gct gcg tat agc tcc gat gga acc act 3139 Gly Arg Ala Ser Phe Ser Asn Ala Ala Tyr Ser Ser Asp Gly Thr Thr 1000 1005 1010 ctc gac ggt gag ggt gcg agc gtt gat gca cag ggt aac ccg ctt cat 3187 Leu Asp Gly Glu Gly Ala Ser Val Asp Ala Gln Gly Asn Pro Leu His 1015 1020 1025 gct gat ggc aca cca atg agt gct gct gaa gct gaa atg aag atg gct 3235 Ala Asp Gly Thr Pro Met Ser Ala Ala Glu Ala Glu Met Lys Met Ala 1030 1035 1040 1045 ggt ctg agc tcg tca gga acc atg atg gag aaa tct ggt gtg aaa tcg 3283 Gly Leu Ser Ser Ser Gly Thr Met Met Glu Lys Ser Gly Val Lys Ser 1050 1055 1060 agt ggc att acc act gca gcg gat gtc atg gac gat cag tct ctg gca 3331 Ser Gly Ile Thr Thr Ala Ala Asp Val Met Asp Asp Gln Ser Leu Ala 1065 1070 1075 agc agt gtc act gag tct ggt ctg tcc aag att cca gac acc tat ggt 3379 Ser Ser Val Thr Glu Ser Gly Leu Ser Lys Ile Pro Asp Thr Tyr Gly 1080 1085 1090 gca gat gtc tcg ggt gct gcg ggc aca gtc gga act acc ggt gct gat 3427 Ala Asp Val Ser Gly Ala Ala Gly Thr Val Gly Thr Thr Gly Ala Asp 1095 1100 1105 tac agt gcg acc gat tca agc gca ggt ctg aac atg agc gag gct gca 3475 Tyr Ser Ala Thr Asp Ser Ser Ala Gly Leu Asn Met Ser Glu Ala Ala 1110 1115 1120 1125 ttg cag agt ggc acc cca atg ggc gct ctc gct ggt gga tct gtg tcg 3523 Leu Gln Ser Gly Thr Pro Met Gly Ala Leu Ala Gly Gly Ser Val Ser 1130 1135 1140 agt tcc gat cag gcc atg aat gac gca gct ctt cag att gca gcg tct 3571 Ser Ser Asp Gln Ala Met Asn Asp Ala Ala Leu Gln Ile Ala Ala Ser 1145 1150 1155 cag ggt ctt gca cca gca ggt tcc ata gct ggt atg gag caa ctt agt 3619 Gln Gly Leu Ala Pro Ala Gly Ser Ile Ala Gly Met Glu Gln Leu Ser 1160 1165 1170 gct caa gcc act gaa gca cct gct gga aag gcc ggc aag cag ctt ggc 3667 Ala Gln Ala Thr Glu Ala Pro Ala Gly Lys Ala Gly Lys Gln Leu Gly 1175 1180 1185 gat ctt tct ggc tca gcg ctc aat act cag ctg gcg tcc atg gga cag 3715 Asp Leu Ser Gly Ser Ala Leu Asn Thr Gln Leu Ala Ser Met Gly Gln 1190 1195 1200 1205 cag gta ggt gac agt gtg aac agc gct tat gct gca ggc ggt atg ggt 3763 Gln Val Gly Asp Ser Val Asn Ser Ala Tyr Ala Ala Gly Gly Met Gly 1210 1215 1220 ggt gtt gat gtg gct ggc aag gtc acc gag gca gca cag cac ttg tct 3811 Gly Val Asp Val Ala Gly Lys Val Thr Glu Ala Ala Gln His Leu Ser 1225 1230 1235 cag gtt cca ggt cag att cag aat gct gtg acc aat gcg gat gct ggt 3859 Gln Val Pro Gly Gln Ile Gln Asn Ala Val Thr Asn Ala Asp Ala Gly 1240 1245 1250 tcc tct ggc gca agc ttt ggt cag atg gca cag ggg gca gct ggt att 3907 Ser Ser Gly Ala Ser Phe Gly Gln Met Ala Gln Gly Ala Ala Gly Ile 1255 1260 1265 gcc ggt gtc gca ggt gtg atc ggt gca gcg ggc gca gca agc tct gca 3955 Ala Gly Val Ala Gly Val Ile Gly Ala Ala Gly Ala Ala Ser Ser Ala 1270 1275 1280 1285 gca caa ggc gca ggt act gtc cag ggt gcg atg ggt aat gct gca gct 4003 Ala Gln Gly Ala Gly Thr Val Gln Gly Ala Met Gly Asn Ala Ala Ala 1290 1295 1300 ggt gcg gga atg atc aac aac gct gtt tcc ggt gga gct act ggc tca 4051 Gly Ala Gly Met Ile Asn Asn Ala Val Ser Gly Gly Ala Thr Gly Ser 1305 1310 1315 aca ggt gcc gca cat gtg gtc aat gca tca cat gga cca gtg gcg cct 4099 Thr Gly Ala Ala His Val Val Asn Ala Ser His Gly Pro Val Ala Pro 1320 1325 1330 ggt cag gct cac tac caa gag tct ggt cat gca caa gca ttt gtg cag 4147 Gly Gln Ala His Tyr Gln Glu Ser Gly His Ala Gln Ala Phe Val Gln 1335 1340 1345 aac aac cag gcc aac acc gcg cac aca gca aac acg cgt gca ccg tca 4195 Asn Asn Gln Ala Asn Thr Ala His Thr Ala Asn Thr Arg Ala Pro Ser 1350 1355 1360 1365 tca gct caa att atg ggc gcg aac gtt gct ggc tca ctg gca tca cag 4243 Ser Ala Gln Ile Met Gly Ala Asn Val Ala Gly Ser Leu Ala Ser Gln 1370 1375 1380 gct gta cga gga atc ggt cag cct ggt cag atg ggt gct aat gtt cgc 4291 Ala Val Arg Gly Ile Gly Gln Pro Gly Gln Met Gly Ala Asn Val Arg 1385 1390 1395 gac gcg atg ggt ggc agc gga cgc tct ggt ggc cgt ggt gga gca act 4339 Asp Ala Met Gly Gly Ser Gly Arg Ser Gly Gly Arg Gly Gly Ala Thr 1400 1405 1410 caa ggc ggt cga ggc gca cag cgc agc ggt gtc agt gct aag aac ggt 4387 Gln Gly Gly Arg Gly Ala Gln Arg Ser Gly Val Ser Ala Lys Asn Gly 1415 1420 1425 atc cgt gca cag cga ggt cag aag cct tct gtg acc ggc cag gcg atg 4435 Ile Arg Ala Gln Arg Gly Gln Lys Pro Ser Val Thr Gly Gln Ala Met 1430 1435 1440 1445 aat gca gca atg cgt tca gca gcg gta agc ggt cgc atg gca aac atg 4483 Asn Ala Ala Met Arg Ser Ala Ala Val Ser Gly Arg Met Ala Asn Met 1450 1455 1460 gac ggc aac agt gta ggt ggc act gaa gca gat cca cag cag ggg agt 4531 Asp Gly Asn Ser Val Gly Gly Thr Glu Ala Asp Pro Gln Gln Gly Ser 1465 1470 1475 ggc gta acc gag aag ggt gat aaa ggc gtt aaa tagcgtgtaa aacacaatga 4584 Gly Val Thr Glu Lys Gly Asp Lys Gly Val Lys 1480 1485 ccgtggagag 4594 <210> 192 <211> 1488 <212> PRT <213> Corynebacterium glutamicum <400> 192 Val Thr Ala Thr Val Leu Glu Pro Gln Pro Val Gln Leu Ser Glu Gln 1 5 10 15 Asp Val Asp Ala Glu Ile Ala Arg Met Glu Leu Lys His Asn Arg His 20 25 30 Lys Thr Trp Arg Arg Arg Thr Met Ala Val Val Met Thr Leu Leu Ile 35 40 45 Ser Val Gly Leu Ser Phe Gly Ala Phe Gly Asn Lys Glu Arg Glu Ala 50 55 60 Asn Ala Phe Ala Ser Ala Ile Ile Ala Gln Val Val Gly Ala Met Gly 65 70 75 80 Glu Val Ala Phe Glu Ala Ile Cys Pro Ser Asp Gly Asp Thr Glu Met 85 90 95 Leu Leu Lys Cys Ile Thr Glu Asn Leu Gly Glu Met His Ile Ile Glu 100 105 110 Lys Cys Leu Glu Ala Glu Asp Val Leu Lys Cys Phe Tyr Asp Ala Lys 115 120 125 Asn Glu Glu Gln Arg Lys Glu Gln Asn Leu Asp Lys Ala Pro Asp Tyr 130 135 140 Ser Met Tyr Arg Met Ala Ser Ala Met Ala Ser Phe Tyr Gly Asn Gly 145 150 155 160 Arg Ala Ala Thr Ala Gly Val Glu Glu Gly Gly Pro Asn Glu Phe Leu 165 170 175 Asp Ser Glu Asp Ala Gly Leu Lys Val Trp Glu Gly Ile Leu Ser Lys 180 185 190 Ala Ala Asn Gly Gly Asn Val Leu Gly Tyr Ala Asp Ala Lys His Asn 195 200 205 Glu Asp Ser Gly Trp Phe Phe Gly Asn Gly Val Ala Asn Asn Glu Lys 210 215 220 Thr Tyr Ser Tyr Asp Ser Leu Ala Asp His Ala Phe Gln Gly Pro Tyr 225 230 235 240 His Phe Ala Leu Phe Gly Ala Thr Leu Ser Gly Leu Gly Phe Asp Ser 245 250 255 Ser Lys Ala Glu Asp Ser Gln Thr Asp Phe Ala Gln Arg Lys Gly Met 260 265 270 Gly Tyr Ala Met Met Ile Ala Tyr Ile Ile Ser Gly Gly Ile Asp Leu 275 280 285 Val Phe Asn Thr Val Leu Asn Ile Leu Ser Thr Ile Asn Pro Phe Arg 290 295 300 Leu Leu Val Gly Pro Val Ser Gln Asn Thr Asn Lys Thr Phe Thr Glu 305 310 315 320 Asn Met Ala Gly Gly Gln Thr Thr Glu Gly Thr Pro Phe Glu Gly Met 325 330 335 Thr Asp Phe Phe Gly Leu Ile Tyr Asn Trp Ser Val Thr Val Gly Trp 340 345 350 Leu Ile Val Ile Pro Val Ser Ile Gly Leu Phe Met Met Gly Ala Leu 355 360 365 Met Phe Arg Arg Met Asp Lys Gly Ser Ala Phe Lys Lys Val Val Ile 370 375 380 Arg Val Val Tyr Gly Val Val Gly Leu Pro Leu Leu Gly Val Ser Tyr 385 390 395 400 Thr Gly Ala Leu Asp Ser Phe Leu Asp Ser Gly Ser Ser Thr Ser Ala 405 410 415 Gly Ser Asn Ala Thr Lys Ile Val Leu Ser Thr Tyr Val Asp Phe Gln 420 425 430 Ser Trp Ala Glu Asn Thr Arg Met Arg Val Pro Asp Lys Val Thr Leu 435 440 445 Ala Trp Ser Leu Glu Asp Gln Ala Pro Thr Gly Gln Ser Met Arg Met 450 455 460 Val Arg Asn Ser Ala Leu Glu Ile Asn Ala Gln Ser Asn Glu Ser Phe 465 470 475 480 Thr Thr Phe Lys Asn Pro Gly Ser Met Asp Leu Gly Tyr Ser Met Asp 485 490 495 Trp Met Glu Lys Met Ala Asp Pro Ala Asn Ser Gly Thr Asp Gly Thr 500 505 510 Ser Ser Ser Ser Ala Thr Thr Ile Phe Gln Gly Thr Ile Ala Leu Leu 515 520 525 Ser Arg Tyr Ile Asp Asn Asp Ser Ile Ser Ser Gly Ser Phe Glu Thr 530 535 540 Ser Ile Arg Ser Ala Met Glu Ser Leu Thr Ser Lys Glu Gly Ser Gly 545 550 555 560 Glu Ala Val Ala Gly Gly Asp Val Met Ala Trp Val Thr Gly Tyr Asn 565 570 575 Thr Ala Ser Gly Leu Asn Glu Ile Thr Ala Ala Glu Leu Ala Asp Ala 580 585 590 Asn Asn Pro Leu Leu Glu Val Ser Asp Ser Ala Gly Leu Gln Gly Arg 595 600 605 Pro Ile Asp Arg Asn Ala Val Ser Phe Lys Ser Gly Asp Ala Thr Ala 610 615 620 Ser Cys Asn Asn Ser Val Val Thr Gly Ser Arg Ala Val Val Gly Asp 625 630 635 640 Tyr Arg Ser Asp Cys Asn Met Ser Pro Leu Thr Met Tyr Asn Phe Leu 645 650 655 Asn Thr Ser Phe His Pro Ala Asp Ala Ser Val Phe Ser Thr Ser Thr 660 665 670 Ser Ala Ser Ser Tyr Thr Arg Ala Ser His Ser Ala Val Ser Leu Ile 675 680 685 Gly Ser Gly Ala Met Asn Phe Val Tyr Trp Phe Ser Ala Met Ser Leu 690 695 700 Met Gly Ser Phe Ile Val Ile Gly Ile Gly Tyr Ala Gly Ala Met Leu 705 710 715 720 Phe Asn Thr Ile Arg Arg Thr Leu Ser Leu Ile Gly Ala Val Pro Phe 725 730 735 Ala Ala Met Gly Phe Ile Ala Gly Val Ala Lys Val Ile Val Tyr Thr 740 745 750 Ile Ala Met Leu Val Glu Val Ile Gly Thr Ile Ile Leu Tyr Gln Leu 755 760 765 Ile Thr Arg Phe Leu Met Ala Val Pro Ala Leu Phe Glu Gln Pro Leu 770 775 780 Ala Asp Ser Leu Ser Ser Asn Glu Ser Ala Glu Leu Val Ala Gly Ala 785 790 795 800 Gly Met Gly Leu Val Gly Met Ala Leu Ala Thr Ser Gly Asn Trp Ala 805 810 815 Ile Ala Gly Met Val Ile Thr Val Ala Ser Ser Met Gly Val Ile Ile 820 825 830 Phe Thr Ile Ile Ala Met Lys Val Arg Gly Ser Leu Val Ser Gly Val 835 840 845 Asp Glu Ala Val Thr Ser Val Ile Asn Arg Phe Leu Asp Thr Gln Val 850 855 860 Ser Ser Ala Gly Ala Thr Ser Gly Asp Gly Met Met Arg Arg Ala Ala 865 870 875 880 Ala Thr Gly Leu Gly Ile Gly Ala Thr His Met Val Leu Asn Arg Asp 885 890 895 Gly Asp Gly Gly Gly Ser Asp Ser Gly Ser Gly Gly Ser Gly Gly Gly 900 905 910 Ser Asp Ser Gly Leu Gly Glu Lys Ala Ala Gly Leu Ala Lys Val Val 915 920 925 Thr Thr Val Ala Gly Ala Gly Leu Val Gly Lys Tyr Ala Thr Asp Ala 930 935 940 Leu Asp Asn Tyr Ala Asp Gly Val Ile Asn Gly Asp Gly Asp Gly Ala 945 950 955 960 Phe Ala Ala Gly Gly Asp Ala Thr Val Asp Gly Asp Tyr Val Ala Asp 965 970 975 Gly Asp Ala Ile Ala Ser Ala Asp Ala Asn Ala Asp Phe Val Asp Gly 980 985 990 Val Val Asp Gly Ala Gly Arg Ala Ser Phe Ser Asn Ala Ala Tyr Ser 995 1000 1005 Ser Asp Gly Thr Thr Leu Asp Gly Glu Gly Ala Ser Val Asp Ala Gln 1010 1015 1020 Gly Asn Pro Leu His Ala Asp Gly Thr Pro Met Ser Ala Ala Glu Ala 1025 1030 1035 1040 Glu Met Lys Met Ala Gly Leu Ser Ser Ser Gly Thr Met Met Glu Lys 1045 1050 1055 Ser Gly Val Lys Ser Ser Gly Ile Thr Thr Ala Ala Asp Val Met Asp 1060 1065 1070 Asp Gln Ser Leu Ala Ser Ser Val Thr Glu Ser Gly Leu Ser Lys Ile 1075 1080 1085 Pro Asp Thr Tyr Gly Ala Asp Val Ser Gly Ala Ala Gly Thr Val Gly 1090 1095 1100 Thr Thr Gly Ala Asp Tyr Ser Ala Thr Asp Ser Ser Ala Gly Leu Asn 1105 1110 1115 1120 Met Ser Glu Ala Ala Leu Gln Ser Gly Thr Pro Met Gly Ala Leu Ala 1125 1130 1135 Gly Gly Ser Val Ser Ser Ser Asp Gln Ala Met Asn Asp Ala Ala Leu 1140 1145 1150 Gln Ile Ala Ala Ser Gln Gly Leu Ala Pro Ala Gly Ser Ile Ala Gly 1155 1160 1165 Met Glu Gln Leu Ser Ala Gln Ala Thr Glu Ala Pro Ala Gly Lys Ala 1170 1175 1180 Gly Lys Gln Leu Gly Asp Leu Ser Gly Ser Ala Leu Asn Thr Gln Leu 1185 1190 1195 1200 Ala Ser Met Gly Gln Gln Val Gly Asp Ser Val Asn Ser Ala Tyr Ala 1205 1210 1215 Ala Gly Gly Met Gly Gly Val Asp Val Ala Gly Lys Val Thr Glu Ala 1220 1225 1230 Ala Gln His Leu Ser Gln Val Pro Gly Gln Ile Gln Asn Ala Val Thr 1235 1240 1245 Asn Ala Asp Ala Gly Ser Ser Gly Ala Ser Phe Gly Gln Met Ala Gln 1250 1255 1260 Gly Ala Ala Gly Ile Ala Gly Val Ala Gly Val Ile Gly Ala Ala Gly 1265 1270 1275 1280 Ala Ala Ser Ser Ala Ala Gln Gly Ala Gly Thr Val Gln Gly Ala Met 1285 1290 1295 Gly Asn Ala Ala Ala Gly Ala Gly Met Ile Asn Asn Ala Val Ser Gly 1300 1305 1310 Gly Ala Thr Gly Ser Thr Gly Ala Ala His Val Val Asn Ala Ser His 1315 1320 1325 Gly Pro Val Ala Pro Gly Gln Ala His Tyr Gln Glu Ser Gly His Ala 1330 1335 1340 Gln Ala Phe Val Gln Asn Asn Gln Ala Asn Thr Ala His Thr Ala Asn 1345 1350 1355 1360 Thr Arg Ala Pro Ser Ser Ala Gln Ile Met Gly Ala Asn Val Ala Gly 1365 1370 1375 Ser Leu Ala Ser Gln Ala Val Arg Gly Ile Gly Gln Pro Gly Gln Met 1380 1385 1390 Gly Ala Asn Val Arg Asp Ala Met Gly Gly Ser Gly Arg Ser Gly Gly 1395 1400 1405 Arg Gly Gly Ala Thr Gln Gly Gly Arg Gly Ala Gln Arg Ser Gly Val 1410 1415 1420 Ser Ala Lys Asn Gly Ile Arg Ala Gln Arg Gly Gln Lys Pro Ser Val 1425 1430 1435 1440 Thr Gly Gln Ala Met Asn Ala Ala Met Arg Ser Ala Ala Val Ser Gly 1445 1450 1455 Arg Met Ala Asn Met Asp Gly Asn Ser Val Gly Gly Thr Glu Ala Asp 1460 1465 1470 Pro Gln Gln Gly Ser Gly Val Thr Glu Lys Gly Asp Lys Gly Val Lys 1475 1480 1485 <210> 193 <211> 3895 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3865) <223> RXA01770 <400> 193 tgctcatgac aggtaattca acgcgttacc ctgctgcagc ataaaagaac ctgcctcaac 60 acacctccac tttttctact tttaagaaag ccacattctc atg cca att atc att 115 Met Pro Ile Ile Ile 1 5 gat aac ctc aat tct gac gac gac tcc acc atc ggc act gcc acc gaa 163 Asp Asn Leu Asn Ser Asp Asp Asp Ser Thr Ile Gly Thr Ala Thr Glu 10 15 20 tac aac cct gac act gac gcc gat tta ctt gat gct att aac gct gat 211 Tyr Asn Pro Asp Thr Asp Ala Asp Leu Leu Asp Ala Ile Asn Ala Asp 25 30 35 gct gac ctt gat ggc gac gcc acc atc agc act aac gcg aca gaa gaa 259 Ala Asp Leu Asp Gly Asp Ala Thr Ile Ser Thr Asn Ala Thr Glu Glu 40 45 50 ggt gta gac gca gca gct gaa aaa cct aag aaa aag cgt aaa gcc cct 307 Gly Val Asp Ala Ala Ala Glu Lys Pro Lys Lys Lys Arg Lys Ala Pro 55 60 65 gct ctg aag cct aaa gga ctc acg gca aag ttc ttc cac cgt gat ctt 355 Ala Leu Lys Pro Lys Gly Leu Thr Ala Lys Phe Phe His Arg Asp Leu 70 75 80 85 act ggc gta ggt ggt agg acc ggt cgc ctc aac aag aac gta cac ccg 403 Thr Gly Val Gly Gly Arg Thr Gly Arg Leu Asn Lys Asn Val His Pro 90 95 100 acc aac cca gat ctg tcc tac cag cca gtc tct gat gtc tac acc cca 451 Thr Asn Pro Asp Leu Ser Tyr Gln Pro Val Ser Asp Val Tyr Thr Pro 105 110 115 caa tca gca gat cac aag ggt att aag acc cgc tac atc ctt acc cat 499 Gln Ser Ala Asp His Lys Gly Ile Lys Thr Arg Tyr Ile Leu Thr His 120 125 130 cca acc ccc gct gtt gtt ctc agt gag tcc atc agc aac gcg ttt cat 547 Pro Thr Pro Ala Val Val Leu Ser Glu Ser Ile Ser Asn Ala Phe His 135 140 145 gtc tct acc ctg cgt cgc aac aat aat gtc aac aac tct gat tcg gaa 595 Val Ser Thr Leu Arg Arg Asn Asn Asn Val Asn Asn Ser Asp Ser Glu 150 155 160 165 ttg gct gcc tgg ccg tac ctc tac caa ctc gat att ccg cag ctg gac 643 Leu Ala Ala Trp Pro Tyr Leu Tyr Gln Leu Asp Ile Pro Gln Leu Asp 170 175 180 cag atg att aat gtc gct gac atc tgt gat tac cat ttc cac gga tat 691 Gln Met Ile Asn Val Ala Asp Ile Cys Asp Tyr His Phe His Gly Tyr 185 190 195 aac ctg tgg gtg gat ttt acc ccg cag act atc gct cta cga tcc ggt 739 Asn Leu Trp Val Asp Phe Thr Pro Gln Thr Ile Ala Leu Arg Ser Gly 200 205 210 aag acg gta ctc gat gac ggt acc acc gcc tct gat aac acc act cat 787 Lys Thr Val Leu Asp Asp Gly Thr Thr Ala Ser Asp Asn Thr Thr His 215 220 225 gtc tat tac cgc gtc acc gtt cac gtt att gcc ggt caa gat cat gga 835 Val Tyr Tyr Arg Val Thr Val His Val Ile Ala Gly Gln Asp His Gly 230 235 240 245 tct act ctg ctt gat gac cag ggc aac cag gtg ctt gat agg gat gat 883 Ser Thr Leu Leu Asp Asp Gln Gly Asn Gln Val Leu Asp Arg Asp Asp 250 255 260 aat cct att tct acc cca agt atc aag cgt att ggc gct gtc act gat 931 Asn Pro Ile Ser Thr Pro Ser Ile Lys Arg Ile Gly Ala Val Thr Asp 265 270 275 ctt ttc gat cac aat cct ttt ggc ttc gct agt gta aac tct ttc gca 979 Leu Phe Asp His Asn Pro Phe Gly Phe Ala Ser Val Asn Ser Phe Ala 280 285 290 ttt gtc gat ttc tca tgg gac cca gcc acc acc ttg gtc gat atg ctc 1027 Phe Val Asp Phe Ser Trp Asp Pro Ala Thr Thr Leu Val Asp Met Leu 295 300 305 aac aac ctt gat tca tat ctc tct aat cac atc aat att gcc agc tcc 1075 Asn Asn Leu Asp Ser Tyr Leu Ser Asn His Ile Asn Ile Ala Ser Ser 310 315 320 325 cca acc ccc att gcc ctc gat atg gtt gtg ctc aat gaa tgg tct gaa 1123 Pro Thr Pro Ile Ala Leu Asp Met Val Val Leu Asn Glu Trp Ser Glu 330 335 340 aag tcc tat cag ctg tgc gaa cgc gtt gtt gca cag gca aag ctc atc 1171 Lys Ser Tyr Gln Leu Cys Glu Arg Val Val Ala Gln Ala Lys Leu Ile 345 350 355 aac agc aac aag atc acc gca cat gtg agt gat gtc atc aag caa aat 1219 Asn Ser Asn Lys Ile Thr Ala His Val Ser Asp Val Ile Lys Gln Asn 360 365 370 gcc cac aat atc ttg tgg ttt acc gaa cag atg aac cct ggc acc acc 1267 Ala His Asn Ile Leu Trp Phe Thr Glu Gln Met Asn Pro Gly Thr Thr 375 380 385 aac ctc agc gag gta cct atc tcc aag aag tct atg ctg ccg atg tct 1315 Asn Leu Ser Glu Val Pro Ile Ser Lys Lys Ser Met Leu Pro Met Ser 390 395 400 405 cgc cag cta cgt att ttg gag cac tac gat gta cca ctg acc gcg tac 1363 Arg Gln Leu Arg Ile Leu Glu His Tyr Asp Val Pro Leu Thr Ala Tyr 410 415 420 tct gct ctt ttc tgg act gtc agc gcc att aag aat gaa tct atg gtg 1411 Ser Ala Leu Phe Trp Thr Val Ser Ala Ile Lys Asn Glu Ser Met Val 425 430 435 cag tac ctt gtg cga cag aat atg cag ctc acc ttg agc tca aat ctg 1459 Gln Tyr Leu Val Arg Gln Asn Met Gln Leu Thr Leu Ser Ser Asn Leu 440 445 450 gat gca ctc aac tcc att gtc tcc cag ctc cct gta cca gat aag gac 1507 Asp Ala Leu Asn Ser Ile Val Ser Gln Leu Pro Val Pro Asp Lys Asp 455 460 465 gtt gtg gct gct tct ggc tac cag att cag cca cac ttc tcc acg cag 1555 Val Val Ala Ala Ser Gly Tyr Gln Ile Gln Pro His Phe Ser Thr Gln 470 475 480 485 cag cgt gaa gca atc acc act gat aat cct ctc gcg att att cag gcc 1603 Gln Arg Glu Ala Ile Thr Thr Asp Asn Pro Leu Ala Ile Ile Gln Ala 490 495 500 ggt gct ggt acc ggt aaa tcc acc gtg att ctg gaa cgc att gag tac 1651 Gly Ala Gly Thr Gly Lys Ser Thr Val Ile Leu Glu Arg Ile Glu Tyr 505 510 515 ttg tgc gct gca ggc acc aac cct gaa gag att gct gtg ctg tct ttt 1699 Leu Cys Ala Ala Gly Thr Asn Pro Glu Glu Ile Ala Val Leu Ser Phe 520 525 530 act aat gct gcc gcc gat aac atc aca gca aaa aat gac aag gtg acc 1747 Thr Asn Ala Ala Ala Asp Asn Ile Thr Ala Lys Asn Asp Lys Val Thr 535 540 545 tct atg acc atc tcc aag atg gtt cat gag att tac gca cac aat ttc 1795 Ser Met Thr Ile Ser Lys Met Val His Glu Ile Tyr Ala His Asn Phe 550 555 560 565 cct gat cat gag atc tcc acc atc gac acc att atc aat acg ctt gat 1843 Pro Asp His Glu Ile Ser Thr Ile Asp Thr Ile Ile Asn Thr Leu Asp 570 575 580 att gaa tac ggc gat caa atg gtg acc tcc gat tac atg att cag ctc 1891 Ile Glu Tyr Gly Asp Gln Met Val Thr Ser Asp Tyr Met Ile Gln Leu 585 590 595 cgt gac ctg ctc tat aag gtc atg acg cag ggt ggc aac gcc aac ctg 1939 Arg Asp Leu Leu Tyr Lys Val Met Thr Gln Gly Gly Asn Ala Asn Leu 600 605 610 aca gcg ttg agc atc ttc atg gaa tcc cat atc gag gcg ttc atc tcg 1987 Thr Ala Leu Ser Ile Phe Met Glu Ser His Ile Glu Ala Phe Ile Ser 615 620 625 gtg ttg gat cag atc aag cag act tct ctt gag ctg gaa atc atc atc 2035 Val Leu Asp Gln Ile Lys Gln Thr Ser Leu Glu Leu Glu Ile Ile Ile 630 635 640 645 tgc tac ctg ctc ttg gat aag ctg atc gag cct cat gca tcg ccg aag 2083 Cys Tyr Leu Leu Leu Asp Lys Leu Ile Glu Pro His Ala Ser Pro Lys 650 655 660 tac ctc att att gat gag gtg cag gac aac tcg gtc ttc gag ttc gtc 2131 Tyr Leu Ile Ile Asp Glu Val Gln Asp Asn Ser Val Phe Glu Phe Val 665 670 675 ttt gca ctt cgt ttt gcg gca aag cac aat acg agt ctg tac ttg gtg 2179 Phe Ala Leu Arg Phe Ala Ala Lys His Asn Thr Ser Leu Tyr Leu Val 680 685 690 ggt gac tcg tca cag acc ttg tat gag ttc cgt tct gct aac cct aag 2227 Gly Asp Ser Ser Gln Thr Leu Tyr Glu Phe Arg Ser Ala Asn Pro Lys 695 700 705 gct ctg aac tcc ctg gaa gca tct ggt gtt ttc ggt acc tac cgt ttg 2275 Ala Leu Asn Ser Leu Glu Ala Ser Gly Val Phe Gly Thr Tyr Arg Leu 710 715 720 725 acc acc aat tac cgt tcc aac cag gaa att ctt gac ttc gct aat atc 2323 Thr Thr Asn Tyr Arg Ser Asn Gln Glu Ile Leu Asp Phe Ala Asn Ile 730 735 740 cac ctc tcg gat att gaa gct aac cag ttc gca ggt att cag ctc tac 2371 His Leu Ser Asp Ile Glu Ala Asn Gln Phe Ala Gly Ile Gln Leu Tyr 745 750 755 gcc aac tct ttt gat gca cct act gcg gac agc ttc aaa gaa aag gtt 2419 Ala Asn Ser Phe Asp Ala Pro Thr Ala Asp Ser Phe Lys Glu Lys Val 760 765 770 gaa ctg gac atg cac cat gtg tct aag cag tct gag ttt acc gac agc 2467 Glu Leu Asp Met His His Val Ser Lys Gln Ser Glu Phe Thr Asp Ser 775 780 785 att cct tat ttc atg gag tcc aat aaa gct cgc ttt gat gct gcg atc 2515 Ile Pro Tyr Phe Met Glu Ser Asn Lys Ala Arg Phe Asp Ala Ala Ile 790 795 800 805 ttg aac aat gag caa acc att gtg ctt gct cat tct ggt cgt gaa att 2563 Leu Asn Asn Glu Gln Thr Ile Val Leu Ala His Ser Gly Arg Glu Ile 810 815 820 cgt gca gcg cag caa gcg cta gcc gag atg tac ccc agc atc acg gtg 2611 Arg Ala Ala Gln Gln Ala Leu Ala Glu Met Tyr Pro Ser Ile Thr Val 825 830 835 cgt aac ttg cag tcc gat aag ggt ttc aac aac acg gta ttt tcg acc 2659 Arg Asn Leu Gln Ser Asp Lys Gly Phe Asn Asn Thr Val Phe Ser Thr 840 845 850 ttt att aag gat ttc tgg ttt gag gtc acc gct gta gac cca gct cat 2707 Phe Ile Lys Asp Phe Trp Phe Glu Val Thr Ala Val Asp Pro Ala His 855 860 865 gcc gca ttt acc ttt acc agc caa gtc acc gct cat cta gat aag ttg 2755 Ala Ala Phe Thr Phe Thr Ser Gln Val Thr Ala His Leu Asp Lys Leu 870 875 880 885 gta cgc gga aag cgt gag cag atg gag gat cgc gtt atc cgg tct atg 2803 Val Arg Gly Lys Arg Glu Gln Met Glu Asp Arg Val Ile Arg Ser Met 890 895 900 gct gca tgg tgg cgt gaa aat gag cgt gac atc cag ggt tgg gtg cag 2851 Ala Ala Trp Trp Arg Glu Asn Glu Arg Asp Ile Gln Gly Trp Val Gln 905 910 915 caa act cag tcc ggt gcg atc acc aac gaa gag ttc ttc tac cgt ctt 2899 Gln Thr Gln Ser Gly Ala Ile Thr Asn Glu Glu Phe Phe Tyr Arg Leu 920 925 930 cgt cag tgc att ctt gac tat gaa atc agg aat aac cga gca cgt cag 2947 Arg Gln Cys Ile Leu Asp Tyr Glu Ile Arg Asn Asn Arg Ala Arg Gln 935 940 945 tcc atg ctc aat gcg cgc aac aac gct aac aag gag gct gtc gca cag 2995 Ser Met Leu Asn Ala Arg Asn Asn Ala Asn Lys Glu Ala Val Ala Gln 950 955 960 965 gag aaa cca ctg ctc atg gtc tcc acc att cac agt gca aag ggt ctg 3043 Glu Lys Pro Leu Leu Met Val Ser Thr Ile His Ser Ala Lys Gly Leu 970 975 980 gaa ttc gat aat gtc atc gtg ctt caa aaa cca agc tcc gat gca gag 3091 Glu Phe Asp Asn Val Ile Val Leu Gln Lys Pro Ser Ser Asp Ala Glu 985 990 995 atg acc gaa gaa ggt aag cgc gca acc tat gtg gcg ctg acc cgt gca 3139 Met Thr Glu Glu Gly Lys Arg Ala Thr Tyr Val Ala Leu Thr Arg Ala 1000 1005 1010 aaa aag cgt gaa ctc att att gct ggt tct act cgc gca tac cca cgc 3187 Lys Lys Arg Glu Leu Ile Ile Ala Gly Ser Thr Arg Ala Tyr Pro Arg 1015 1020 1025 atc gtc acc gat tat gag caa atc gtt gat ctt ctt gaa aag cgc gat 3235 Ile Val Thr Asp Tyr Glu Gln Ile Val Asp Leu Leu Glu Lys Arg Asp 1030 1035 1040 1045 gag gag cgc aaa att aag gag gaa gag gct gca gca ctc gcc acc ctt 3283 Glu Glu Arg Lys Ile Lys Glu Glu Glu Ala Ala Ala Leu Ala Thr Leu 1050 1055 1060 gaa gct gaa cag gag acg cgc gcc ctt gct gct gct gag gcg cag gct 3331 Glu Ala Glu Gln Glu Thr Arg Ala Leu Ala Ala Ala Glu Ala Gln Ala 1065 1070 1075 cag gcg ttg ttg ctt gag cac aac ccg tgg ttg cgt gat ctc agc gat 3379 Gln Ala Leu Leu Leu Glu His Asn Pro Trp Leu Arg Asp Leu Ser Asp 1080 1085 1090 gaa gaa gtc act gct cta act gag caa gag atc atc aac aat gtt gag 3427 Glu Glu Val Thr Ala Leu Thr Glu Gln Glu Ile Ile Asn Asn Val Glu 1095 1100 1105 gca gcc cta cag att gaa gaa gag gag gaa gag gct cgt gca ctc gct 3475 Ala Ala Leu Gln Ile Glu Glu Glu Glu Glu Glu Ala Arg Ala Leu Ala 1110 1115 1120 1125 gca gca gag cca gca att cag cag tac ttg tct cag ttt gct ttc gat 3523 Ala Ala Glu Pro Ala Ile Gln Gln Tyr Leu Ser Gln Phe Ala Phe Asp 1130 1135 1140 gag ttc ccg gac gac gac aat gta gcc aac act gtc gta cat gta gca 3571 Glu Phe Pro Asp Asp Asp Asn Val Ala Asn Thr Val Val His Val Ala 1145 1150 1155 cca cag cct att ctc cac cag gca gtg cct gca gat gtg act gta caa 3619 Pro Gln Pro Ile Leu His Gln Ala Val Pro Ala Asp Val Thr Val Gln 1160 1165 1170 tca agc acc gcc ccc gta aca cct gtt gtt gcg gat ctt gag gta acc 3667 Ser Ser Thr Ala Pro Val Thr Pro Val Val Ala Asp Leu Glu Val Thr 1175 1180 1185 act gtt gca gct gat cca gtc gaa ccg act atc gtt gct gca cag cct 3715 Thr Val Ala Ala Asp Pro Val Glu Pro Thr Ile Val Ala Ala Gln Pro 1190 1195 1200 1205 gag gtg gac gac aac ctt gtc tac agc acg tcc acc cct aat agt cac 3763 Glu Val Asp Asp Asn Leu Val Tyr Ser Thr Ser Thr Pro Asn Ser His 1210 1215 1220 agt gac gtt att gca gtg aac tct gat acc tca gaa aac gct gct gtt 3811 Ser Asp Val Ile Ala Val Asn Ser Asp Thr Ser Glu Asn Ala Ala Val 1225 1230 1235 aat cca gtt ctg tcc gat att gag gca ctc cga gca att ttc aac aac 3859 Asn Pro Val Leu Ser Asp Ile Glu Ala Leu Arg Ala Ile Phe Asn Asn 1240 1245 1250 cag gac taaaacacct gctgctgttg agcgcttctc 3895 Gln Asp 1255 <210> 194 <211> 1255 <212> PRT <213> Corynebacterium glutamicum <400> 194 Met Pro Ile Ile Ile Asp Asn Leu Asn Ser Asp Asp Asp Ser Thr Ile 1 5 10 15 Gly Thr Ala Thr Glu Tyr Asn Pro Asp Thr Asp Ala Asp Leu Leu Asp 20 25 30 Ala Ile Asn Ala Asp Ala Asp Leu Asp Gly Asp Ala Thr Ile Ser Thr 35 40 45 Asn Ala Thr Glu Glu Gly Val Asp Ala Ala Ala Glu Lys Pro Lys Lys 50 55 60 Lys Arg Lys Ala Pro Ala Leu Lys Pro Lys Gly Leu Thr Ala Lys Phe 65 70 75 80 Phe His Arg Asp Leu Thr Gly Val Gly Gly Arg Thr Gly Arg Leu Asn 85 90 95 Lys Asn Val His Pro Thr Asn Pro Asp Leu Ser Tyr Gln Pro Val Ser 100 105 110 Asp Val Tyr Thr Pro Gln Ser Ala Asp His Lys Gly Ile Lys Thr Arg 115 120 125 Tyr Ile Leu Thr His Pro Thr Pro Ala Val Val Leu Ser Glu Ser Ile 130 135 140 Ser Asn Ala Phe His Val Ser Thr Leu Arg Arg Asn Asn Asn Val Asn 145 150 155 160 Asn Ser Asp Ser Glu Leu Ala Ala Trp Pro Tyr Leu Tyr Gln Leu Asp 165 170 175 Ile Pro Gln Leu Asp Gln Met Ile Asn Val Ala Asp Ile Cys Asp Tyr 180 185 190 His Phe His Gly Tyr Asn Leu Trp Val Asp Phe Thr Pro Gln Thr Ile 195 200 205 Ala Leu Arg Ser Gly Lys Thr Val Leu Asp Asp Gly Thr Thr Ala Ser 210 215 220 Asp Asn Thr Thr His Val Tyr Tyr Arg Val Thr Val His Val Ile Ala 225 230 235 240 Gly Gln Asp His Gly Ser Thr Leu Leu Asp Asp Gln Gly Asn Gln Val 245 250 255 Leu Asp Arg Asp Asp Asn Pro Ile Ser Thr Pro Ser Ile Lys Arg Ile 260 265 270 Gly Ala Val Thr Asp Leu Phe Asp His Asn Pro Phe Gly Phe Ala Ser 275 280 285 Val Asn Ser Phe Ala Phe Val Asp Phe Ser Trp Asp Pro Ala Thr Thr 290 295 300 Leu Val Asp Met Leu Asn Asn Leu Asp Ser Tyr Leu Ser Asn His Ile 305 310 315 320 Asn Ile Ala Ser Ser Pro Thr Pro Ile Ala Leu Asp Met Val Val Leu 325 330 335 Asn Glu Trp Ser Glu Lys Ser Tyr Gln Leu Cys Glu Arg Val Val Ala 340 345 350 Gln Ala Lys Leu Ile Asn Ser Asn Lys Ile Thr Ala His Val Ser Asp 355 360 365 Val Ile Lys Gln Asn Ala His Asn Ile Leu Trp Phe Thr Glu Gln Met 370 375 380 Asn Pro Gly Thr Thr Asn Leu Ser Glu Val Pro Ile Ser Lys Lys Ser 385 390 395 400 Met Leu Pro Met Ser Arg Gln Leu Arg Ile Leu Glu His Tyr Asp Val 405 410 415 Pro Leu Thr Ala Tyr Ser Ala Leu Phe Trp Thr Val Ser Ala Ile Lys 420 425 430 Asn Glu Ser Met Val Gln Tyr Leu Val Arg Gln Asn Met Gln Leu Thr 435 440 445 Leu Ser Ser Asn Leu Asp Ala Leu Asn Ser Ile Val Ser Gln Leu Pro 450 455 460 Val Pro Asp Lys Asp Val Val Ala Ala Ser Gly Tyr Gln Ile Gln Pro 465 470 475 480 His Phe Ser Thr Gln Gln Arg Glu Ala Ile Thr Thr Asp Asn Pro Leu 485 490 495 Ala Ile Ile Gln Ala Gly Ala Gly Thr Gly Lys Ser Thr Val Ile Leu 500 505 510 Glu Arg Ile Glu Tyr Leu Cys Ala Ala Gly Thr Asn Pro Glu Glu Ile 515 520 525 Ala Val Leu Ser Phe Thr Asn Ala Ala Ala Asp Asn Ile Thr Ala Lys 530 535 540 Asn Asp Lys Val Thr Ser Met Thr Ile Ser Lys Met Val His Glu Ile 545 550 555 560 Tyr Ala His Asn Phe Pro Asp His Glu Ile Ser Thr Ile Asp Thr Ile 565 570 575 Ile Asn Thr Leu Asp Ile Glu Tyr Gly Asp Gln Met Val Thr Ser Asp 580 585 590 Tyr Met Ile Gln Leu Arg Asp Leu Leu Tyr Lys Val Met Thr Gln Gly 595 600 605 Gly Asn Ala Asn Leu Thr Ala Leu Ser Ile Phe Met Glu Ser His Ile 610 615 620 Glu Ala Phe Ile Ser Val Leu Asp Gln Ile Lys Gln Thr Ser Leu Glu 625 630 635 640 Leu Glu Ile Ile Ile Cys Tyr Leu Leu Leu Asp Lys Leu Ile Glu Pro 645 650 655 His Ala Ser Pro Lys Tyr Leu Ile Ile Asp Glu Val Gln Asp Asn Ser 660 665 670 Val Phe Glu Phe Val Phe Ala Leu Arg Phe Ala Ala Lys His Asn Thr 675 680 685 Ser Leu Tyr Leu Val Gly Asp Ser Ser Gln Thr Leu Tyr Glu Phe Arg 690 695 700 Ser Ala Asn Pro Lys Ala Leu Asn Ser Leu Glu Ala Ser Gly Val Phe 705 710 715 720 Gly Thr Tyr Arg Leu Thr Thr Asn Tyr Arg Ser Asn Gln Glu Ile Leu 725 730 735 Asp Phe Ala Asn Ile His Leu Ser Asp Ile Glu Ala Asn Gln Phe Ala 740 745 750 Gly Ile Gln Leu Tyr Ala Asn Ser Phe Asp Ala Pro Thr Ala Asp Ser 755 760 765 Phe Lys Glu Lys Val Glu Leu Asp Met His His Val Ser Lys Gln Ser 770 775 780 Glu Phe Thr Asp Ser Ile Pro Tyr Phe Met Glu Ser Asn Lys Ala Arg 785 790 795 800 Phe Asp Ala Ala Ile Leu Asn Asn Glu Gln Thr Ile Val Leu Ala His 805 810 815 Ser Gly Arg Glu Ile Arg Ala Ala Gln Gln Ala Leu Ala Glu Met Tyr 820 825 830 Pro Ser Ile Thr Val Arg Asn Leu Gln Ser Asp Lys Gly Phe Asn Asn 835 840 845 Thr Val Phe Ser Thr Phe Ile Lys Asp Phe Trp Phe Glu Val Thr Ala 850 855 860 Val Asp Pro Ala His Ala Ala Phe Thr Phe Thr Ser Gln Val Thr Ala 865 870 875 880 His Leu Asp Lys Leu Val Arg Gly Lys Arg Glu Gln Met Glu Asp Arg 885 890 895 Val Ile Arg Ser Met Ala Ala Trp Trp Arg Glu Asn Glu Arg Asp Ile 900 905 910 Gln Gly Trp Val Gln Gln Thr Gln Ser Gly Ala Ile Thr Asn Glu Glu 915 920 925 Phe Phe Tyr Arg Leu Arg Gln Cys Ile Leu Asp Tyr Glu Ile Arg Asn 930 935 940 Asn Arg Ala Arg Gln Ser Met Leu Asn Ala Arg Asn Asn Ala Asn Lys 945 950 955 960 Glu Ala Val Ala Gln Glu Lys Pro Leu Leu Met Val Ser Thr Ile His 965 970 975 Ser Ala Lys Gly Leu Glu Phe Asp Asn Val Ile Val Leu Gln Lys Pro 980 985 990 Ser Ser Asp Ala Glu Met Thr Glu Glu Gly Lys Arg Ala Thr Tyr Val 995 1000 1005 Ala Leu Thr Arg Ala Lys Lys Arg Glu Leu Ile Ile Ala Gly Ser Thr 1010 1015 1020 Arg Ala Tyr Pro Arg Ile Val Thr Asp Tyr Glu Gln Ile Val Asp Leu 1025 1030 1035 1040 Leu Glu Lys Arg Asp Glu Glu Arg Lys Ile Lys Glu Glu Glu Ala Ala 1045 1050 1055 Ala Leu Ala Thr Leu Glu Ala Glu Gln Glu Thr Arg Ala Leu Ala Ala 1060 1065 1070 Ala Glu Ala Gln Ala Gln Ala Leu Leu Leu Glu His Asn Pro Trp Leu 1075 1080 1085 Arg Asp Leu Ser Asp Glu Glu Val Thr Ala Leu Thr Glu Gln Glu Ile 1090 1095 1100 Ile Asn Asn Val Glu Ala Ala Leu Gln Ile Glu Glu Glu Glu Glu Glu 1105 1110 1115 1120 Ala Arg Ala Leu Ala Ala Ala Glu Pro Ala Ile Gln Gln Tyr Leu Ser 1125 1130 1135 Gln Phe Ala Phe Asp Glu Phe Pro Asp Asp Asp Asn Val Ala Asn Thr 1140 1145 1150 Val Val His Val Ala Pro Gln Pro Ile Leu His Gln Ala Val Pro Ala 1155 1160 1165 Asp Val Thr Val Gln Ser Ser Thr Ala Pro Val Thr Pro Val Val Ala 1170 1175 1180 Asp Leu Glu Val Thr Thr Val Ala Ala Asp Pro Val Glu Pro Thr Ile 1185 1190 1195 1200 Val Ala Ala Gln Pro Glu Val Asp Asp Asn Leu Val Tyr Ser Thr Ser 1205 1210 1215 Thr Pro Asn Ser His Ser Asp Val Ile Ala Val Asn Ser Asp Thr Ser 1220 1225 1230 Glu Asn Ala Ala Val Asn Pro Val Leu Ser Asp Ile Glu Ala Leu Arg 1235 1240 1245 Ala Ile Phe Asn Asn Gln Asp 1250 1255 <210> 195 <211> 874 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(844) <223> RXA01771 <400> 195 ccggcccgat cctaaaacta taagttttgg gggacgcacc gctgccccgc tgttggtggt 60 tccggagcgg cgataatcgc taaacgtttg aggtgattgt atg ggt att ttc agg 115 Met Gly Ile Phe Arg 1 5 tcg cgg tcg cag gat ttt ggg tgg agc atg cac cag gct ggc cag ctc 163 Ser Arg Ser Gln Asp Phe Gly Trp Ser Met His Gln Ala Gly Gln Leu 10 15 20 atc aat gat ccc agt cag ggt ctg tgg cgc act tct gcc ctg cgc tcg 211 Ile Asn Asp Pro Ser Gln Gly Leu Trp Arg Thr Ser Ala Leu Arg Ser 25 30 35 ccg gtt gct cgg gtt gga cat gcc gtg ttg cgc cag cgt gcc ggt gag 259 Pro Val Ala Arg Val Gly His Ala Val Leu Arg Gln Arg Ala Gly Glu 40 45 50 atc tcg cgc atg caa ggt cgt gag ttt tct cgc cct ggg gat cag ttc 307 Ile Ser Arg Met Gln Gly Arg Glu Phe Ser Arg Pro Gly Asp Gln Phe 55 60 65 cga cag gta gat ttg cgc agg cga ctg att cag gtc cat ccc caa tca 355 Arg Gln Val Asp Leu Arg Arg Arg Leu Ile Gln Val His Pro Gln Ser 70 75 80 85 att cct aca gcg gat gcg atg gcc gta acc atc acc atg gcg ctc acc 403 Ile Pro Thr Ala Asp Ala Met Ala Val Thr Ile Thr Met Ala Leu Thr 90 95 100 gct gcc acg att gat ccg gtg aag ttc gtc gcg gat tca cag aac ccg 451 Ala Ala Thr Ile Asp Pro Val Lys Phe Val Ala Asp Ser Gln Asn Pro 105 110 115 gat gaa gag att tat ttg gca gct cag atc gca ttg cgg gaa atg gtt 499 Asp Glu Glu Ile Tyr Leu Ala Ala Gln Ile Ala Leu Arg Glu Met Val 120 125 130 atc gct atg cct ttg gag gat ttc atc ggg gtg cgc att gat cta gag 547 Ile Ala Met Pro Leu Glu Asp Phe Ile Gly Val Arg Ile Asp Leu Glu 135 140 145 cct gtt ttg gtg gct gct caa gct gct gcg aag aat gtg ggc gtg gaa 595 Pro Val Leu Val Ala Ala Gln Ala Ala Ala Lys Asn Val Gly Val Glu 150 155 160 165 gtc tcg tca atc ttg ctg aag gat ctg aat ctt ccc cag gag tac tcg 643 Val Ser Ser Ile Leu Leu Lys Asp Leu Asn Leu Pro Gln Glu Tyr Ser 170 175 180 gga gcg ttg cag gaa tcg atc gtt gcg aaa att caa gcc gaa act gat 691 Gly Ala Leu Gln Glu Ser Ile Val Ala Lys Ile Gln Ala Glu Thr Asp 185 190 195 ctg gaa cgt gca cga aat gaa gtg aaa act acc cgt gct cga ctt gcc 739 Leu Glu Arg Ala Arg Asn Glu Val Lys Thr Thr Arg Ala Arg Leu Ala 200 205 210 agc gcg aaa gtg ttg gag caa aat ccg att ctt gcc aaa att cgg atg 787 Ser Ala Lys Val Leu Glu Gln Asn Pro Ile Leu Ala Lys Ile Arg Met 215 220 225 att gaa gcg ctc cca ccg gga tcc aca att gag gtt cgg gag ggt gac 835 Ile Glu Ala Leu Pro Pro Gly Ser Thr Ile Glu Val Arg Glu Gly Asp 230 235 240 245 tca aag gca taaagttgcc catttcggtg ccctccacgg 874 Ser Lys Ala <210> 196 <211> 248 <212> PRT <213> Corynebacterium glutamicum <400> 196 Met Gly Ile Phe Arg Ser Arg Ser Gln Asp Phe Gly Trp Ser Met His 1 5 10 15 Gln Ala Gly Gln Leu Ile Asn Asp Pro Ser Gln Gly Leu Trp Arg Thr 20 25 30 Ser Ala Leu Arg Ser Pro Val Ala Arg Val Gly His Ala Val Leu Arg 35 40 45 Gln Arg Ala Gly Glu Ile Ser Arg Met Gln Gly Arg Glu Phe Ser Arg 50 55 60 Pro Gly Asp Gln Phe Arg Gln Val Asp Leu Arg Arg Arg Leu Ile Gln 65 70 75 80 Val His Pro Gln Ser Ile Pro Thr Ala Asp Ala Met Ala Val Thr Ile 85 90 95 Thr Met Ala Leu Thr Ala Ala Thr Ile Asp Pro Val Lys Phe Val Ala 100 105 110 Asp Ser Gln Asn Pro Asp Glu Glu Ile Tyr Leu Ala Ala Gln Ile Ala 115 120 125 Leu Arg Glu Met Val Ile Ala Met Pro Leu Glu Asp Phe Ile Gly Val 130 135 140 Arg Ile Asp Leu Glu Pro Val Leu Val Ala Ala Gln Ala Ala Ala Lys 145 150 155 160 Asn Val Gly Val Glu Val Ser Ser Ile Leu Leu Lys Asp Leu Asn Leu 165 170 175 Pro Gln Glu Tyr Ser Gly Ala Leu Gln Glu Ser Ile Val Ala Lys Ile 180 185 190 Gln Ala Glu Thr Asp Leu Glu Arg Ala Arg Asn Glu Val Lys Thr Thr 195 200 205 Arg Ala Arg Leu Ala Ser Ala Lys Val Leu Glu Gln Asn Pro Ile Leu 210 215 220 Ala Lys Ile Arg Met Ile Glu Ala Leu Pro Pro Gly Ser Thr Ile Glu 225 230 235 240 Val Arg Glu Gly Asp Ser Lys Ala 245 <210> 197 <211> 1582 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1552) <223> RXA01776 <400> 197 cgtataacca cacacgccac agatactcag ctatctgtgg cgtgttgttt tacatcaacc 60 tctcacccat cccccatcac tattaaagaa aatcaccatc atg acc cac act gat 115 Met Thr His Thr Asp 1 5 acc cca gcc cct gca cac ggc gta aca ccg agt gaa ttc gct gtt acc 163 Thr Pro Ala Pro Ala His Gly Val Thr Pro Ser Glu Phe Ala Val Thr 10 15 20 tca cac gaa ctc acc acc tca cca aca cct agt ccg aca cag gtc gct 211 Ser His Glu Leu Thr Thr Ser Pro Thr Pro Ser Pro Thr Gln Val Ala 25 30 35 att gca gcc cag gaa aaa att cgc cag cgc aag ctc gaa gag ctt aaa 259 Ile Ala Ala Gln Glu Lys Ile Arg Gln Arg Lys Leu Glu Glu Leu Lys 40 45 50 gca aaa aag cgc aca gac acg aca gct caa cca ctt cta cct gca cct 307 Ala Lys Lys Arg Thr Asp Thr Thr Ala Gln Pro Leu Leu Pro Ala Pro 55 60 65 gtg ctg cat aca cgc cca ctc ccc tca ccg aat cca ccg cga cca tct 355 Val Leu His Thr Arg Pro Leu Pro Ser Pro Asn Pro Pro Arg Pro Ser 70 75 80 85 cca ccg gca cct acc act gga cac tgg gaa ctt ctt att gtc agg tca 403 Pro Pro Ala Pro Thr Thr Gly His Trp Glu Leu Leu Ile Val Arg Ser 90 95 100 cag cag aag aaa atg acc gca gcc aat ccc ttt ctc aaa ttc ctt cat 451 Gln Gln Lys Lys Met Thr Ala Ala Asn Pro Phe Leu Lys Phe Leu His 105 110 115 ctc ggt aaa gcc ttc aac gtg aaa gac cta ggg ctc acc tgc gat cgc 499 Leu Gly Lys Ala Phe Asn Val Lys Asp Leu Gly Leu Thr Cys Asp Arg 120 125 130 acc act gat gtt gac ctc tca cgg cta ggc aag ctc aat ccg ccc agc 547 Thr Thr Asp Val Asp Leu Ser Arg Leu Gly Lys Leu Asn Pro Pro Ser 135 140 145 tca ctt atc ctt gaa cta gca acg gca ctt gac ctg cat cca ttc ctc 595 Ser Leu Ile Leu Glu Leu Ala Thr Ala Leu Asp Leu His Pro Phe Leu 150 155 160 165 tca gtc gca ctc tct tcg cac agt gcg gtc aac gcc cgt cgc aac caa 643 Ser Val Ala Leu Ser Ser His Ser Ala Val Asn Ala Arg Arg Asn Gln 170 175 180 ctt gaa tta acc ctg cac aac cat gac act cag ggc aca gca tta ggt 691 Leu Glu Leu Thr Leu His Asn His Asp Thr Gln Gly Thr Ala Leu Gly 185 190 195 cac agc gtt act atg gtc cag cta ccc gag gtc att aat cga gct gct 739 His Ser Val Thr Met Val Gln Leu Pro Glu Val Ile Asn Arg Ala Ala 200 205 210 gta gag ccc tat atc aaa ccc aag ggc tcg ggc aat gac ccg ctt gac 787 Val Glu Pro Tyr Ile Lys Pro Lys Gly Ser Gly Asn Asp Pro Leu Asp 215 220 225 caa agc ctg aac cac cgc gca ccc acc gta agt gac gtg caa aaa gcc 835 Gln Ser Leu Asn His Arg Ala Pro Thr Val Ser Asp Val Gln Lys Ala 230 235 240 245 ctt gtg cag gaa aac aca ggc acg gca aca gac agc aac aac tac ctg 883 Leu Val Gln Glu Asn Thr Gly Thr Ala Thr Asp Ser Asn Asn Tyr Leu 250 255 260 ctt cct ttt gat cct gat tct ggt gca cca aaa acc acc gcg ctt aat 931 Leu Pro Phe Asp Pro Asp Ser Gly Ala Pro Lys Thr Thr Ala Leu Asn 265 270 275 gcg cct aat aag gat ctc cta cag gcc agg cat gag ctt gcc tat att 979 Ala Pro Asn Lys Asp Leu Leu Gln Ala Arg His Glu Leu Ala Tyr Ile 280 285 290 ccc gag atc ccc gcc att gca tcg tgg ctc gat cac ctt gac ccc atc 1027 Pro Glu Ile Pro Ala Ile Ala Ser Trp Leu Asp His Leu Asp Pro Ile 295 300 305 atg cgt gtg cac cgt agt ctt gcg ctt tca att ttc cca gtg cag ctt 1075 Met Arg Val His Arg Ser Leu Ala Leu Ser Ile Phe Pro Val Gln Leu 310 315 320 325 cta cgt gct gcc gtt gag aat ctc cct cat aac gta acc gat ctg cat 1123 Leu Arg Ala Ala Val Glu Asn Leu Pro His Asn Val Thr Asp Leu His 330 335 340 aat cac ctt gat cct gag gat ctg ctc cct gag gaa ctc acc acc tgg 1171 Asn His Leu Asp Pro Glu Asp Leu Leu Pro Glu Glu Leu Thr Thr Trp 345 350 355 ctc gat cac ctc ttc gat gca gac tta acc gct ctc gct tca tgc cca 1219 Leu Asp His Leu Phe Asp Ala Asp Leu Thr Ala Leu Ala Ser Cys Pro 360 365 370 cag ctt gca cca cct atc gtg cgc agc cac aat cac gcc aaa gcg atc 1267 Gln Leu Ala Pro Pro Ile Val Arg Ser His Asn His Ala Lys Ala Ile 375 380 385 gca gct atc acc gtg acc tct gtc atg gac gct ctc atc gcc aaa act 1315 Ala Ala Ile Thr Val Thr Ser Val Met Asp Ala Leu Ile Ala Lys Thr 390 395 400 405 ctt gat gcg cat gac gat cca ctg ccc tca cta ccg gag ttt gta gaa 1363 Leu Asp Ala His Asp Asp Pro Leu Pro Ser Leu Pro Glu Phe Val Glu 410 415 420 cta ctg cgt gac gct gta gcc cag ctc gca gcg cat ttt aag cag cag 1411 Leu Leu Arg Asp Ala Val Ala Gln Leu Ala Ala His Phe Lys Gln Gln 425 430 435 cgc ggc gag gta cta ccg cag ccc aat ggc ttg cga tac gcc acc gac 1459 Arg Gly Glu Val Leu Pro Gln Pro Asn Gly Leu Arg Tyr Ala Thr Asp 440 445 450 ttt ggc ctg ctc tct tat att gcc gat ggc tta cat gaa tat gca ctt 1507 Phe Gly Leu Leu Ser Tyr Ile Ala Asp Gly Leu His Glu Tyr Ala Leu 455 460 465 gcc atc gac ttc ggg ctg atc tac ccg aat gaa ctc atc acc gag 1552 Ala Ile Asp Phe Gly Leu Ile Tyr Pro Asn Glu Leu Ile Thr Glu 470 475 480 taaacccact cctagaaagg tctttaccca 1582 <210> 198 <211> 484 <212> PRT <213> Corynebacterium glutamicum <400> 198 Met Thr His Thr Asp Thr Pro Ala Pro Ala His Gly Val Thr Pro Ser 1 5 10 15 Glu Phe Ala Val Thr Ser His Glu Leu Thr Thr Ser Pro Thr Pro Ser 20 25 30 Pro Thr Gln Val Ala Ile Ala Ala Gln Glu Lys Ile Arg Gln Arg Lys 35 40 45 Leu Glu Glu Leu Lys Ala Lys Lys Arg Thr Asp Thr Thr Ala Gln Pro 50 55 60 Leu Leu Pro Ala Pro Val Leu His Thr Arg Pro Leu Pro Ser Pro Asn 65 70 75 80 Pro Pro Arg Pro Ser Pro Pro Ala Pro Thr Thr Gly His Trp Glu Leu 85 90 95 Leu Ile Val Arg Ser Gln Gln Lys Lys Met Thr Ala Ala Asn Pro Phe 100 105 110 Leu Lys Phe Leu His Leu Gly Lys Ala Phe Asn Val Lys Asp Leu Gly 115 120 125 Leu Thr Cys Asp Arg Thr Thr Asp Val Asp Leu Ser Arg Leu Gly Lys 130 135 140 Leu Asn Pro Pro Ser Ser Leu Ile Leu Glu Leu Ala Thr Ala Leu Asp 145 150 155 160 Leu His Pro Phe Leu Ser Val Ala Leu Ser Ser His Ser Ala Val Asn 165 170 175 Ala Arg Arg Asn Gln Leu Glu Leu Thr Leu His Asn His Asp Thr Gln 180 185 190 Gly Thr Ala Leu Gly His Ser Val Thr Met Val Gln Leu Pro Glu Val 195 200 205 Ile Asn Arg Ala Ala Val Glu Pro Tyr Ile Lys Pro Lys Gly Ser Gly 210 215 220 Asn Asp Pro Leu Asp Gln Ser Leu Asn His Arg Ala Pro Thr Val Ser 225 230 235 240 Asp Val Gln Lys Ala Leu Val Gln Glu Asn Thr Gly Thr Ala Thr Asp 245 250 255 Ser Asn Asn Tyr Leu Leu Pro Phe Asp Pro Asp Ser Gly Ala Pro Lys 260 265 270 Thr Thr Ala Leu Asn Ala Pro Asn Lys Asp Leu Leu Gln Ala Arg His 275 280 285 Glu Leu Ala Tyr Ile Pro Glu Ile Pro Ala Ile Ala Ser Trp Leu Asp 290 295 300 His Leu Asp Pro Ile Met Arg Val His Arg Ser Leu Ala Leu Ser Ile 305 310 315 320 Phe Pro Val Gln Leu Leu Arg Ala Ala Val Glu Asn Leu Pro His Asn 325 330 335 Val Thr Asp Leu His Asn His Leu Asp Pro Glu Asp Leu Leu Pro Glu 340 345 350 Glu Leu Thr Thr Trp Leu Asp His Leu Phe Asp Ala Asp Leu Thr Ala 355 360 365 Leu Ala Ser Cys Pro Gln Leu Ala Pro Pro Ile Val Arg Ser His Asn 370 375 380 His Ala Lys Ala Ile Ala Ala Ile Thr Val Thr Ser Val Met Asp Ala 385 390 395 400 Leu Ile Ala Lys Thr Leu Asp Ala His Asp Asp Pro Leu Pro Ser Leu 405 410 415 Pro Glu Phe Val Glu Leu Leu Arg Asp Ala Val Ala Gln Leu Ala Ala 420 425 430 His Phe Lys Gln Gln Arg Gly Glu Val Leu Pro Gln Pro Asn Gly Leu 435 440 445 Arg Tyr Ala Thr Asp Phe Gly Leu Leu Ser Tyr Ile Ala Asp Gly Leu 450 455 460 His Glu Tyr Ala Leu Ala Ile Asp Phe Gly Leu Ile Tyr Pro Asn Glu 465 470 475 480 Leu Ile Thr Glu <210> 199 <211> 1267 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1237) <223> RXA01778 <400> 199 ctactacccc ctccgggtgt ggggtagctg taacaactac cccacaatct cagccggtct 60 tccatacata actgcgaaat tggttagagt ctttttcatg atg ctc tac caa cac 115 Met Leu Tyr Gln His 1 5 acc aca cgc ggg ctg atc att agt gac gcg atc atc gcg aaa atc agc 163 Thr Thr Arg Gly Leu Ile Ile Ser Asp Ala Ile Ile Ala Lys Ile Ser 10 15 20 caa gtc aac caa ctg ctg cta cta aga ccc acg ctg ttg caa gac aaa 211 Gln Val Asn Gln Leu Leu Leu Leu Arg Pro Thr Leu Leu Gln Asp Lys 25 30 35 gat atg cac cat gcg aca ttg agt agc gac acc cca tca att cgc agt 259 Asp Met His His Ala Thr Leu Ser Ser Asp Thr Pro Ser Ile Arg Ser 40 45 50 cgc cgt cgc tcc tat cgc gag aat aaa gcc gcc tat gcg acc acg agc 307 Arg Arg Arg Ser Tyr Arg Glu Asn Lys Ala Ala Tyr Ala Thr Thr Ser 55 60 65 acc atc aga aac cgt gag acc ttt ttc agc aca tct gat att gat ttc 355 Thr Ile Arg Asn Arg Glu Thr Phe Phe Ser Thr Ser Asp Ile Asp Phe 70 75 80 85 gcc ata ctc atg att cag gac gta caa gaa tct ctc gta tct ttt gac 403 Ala Ile Leu Met Ile Gln Asp Val Gln Glu Ser Leu Val Ser Phe Asp 90 95 100 ccc acc ttg gct caa gat atg aag cca aga acc aac gca gtc att tct 451 Pro Thr Leu Ala Gln Asp Met Lys Pro Arg Thr Asn Ala Val Ile Ser 105 110 115 gca ctc aat gag cta cgc gag cca ctg gat acc ttc tac cgt gcc cat 499 Ala Leu Asn Glu Leu Arg Glu Pro Leu Asp Thr Phe Tyr Arg Ala His 120 125 130 gaa tac ggt gac atc atc agc gat ggt gct tat gag ttc gat cat gct 547 Glu Tyr Gly Asp Ile Ile Ser Asp Gly Ala Tyr Glu Phe Asp His Ala 135 140 145 gcc att gat gca caa cac agc ctt agt gaa ctc gtt gcc ggt ctg cat 595 Ala Ile Asp Ala Gln His Ser Leu Ser Glu Leu Val Ala Gly Leu His 150 155 160 165 aat tat gac aac ctc atg ttt ccc cag gaa acc gct ccg ttg atg agt 643 Asn Tyr Asp Asn Leu Met Phe Pro Gln Glu Thr Ala Pro Leu Met Ser 170 175 180 gaa tcc aat ggc att cag ctg gct cag tac tat aag tcc acc aaa ctc 691 Glu Ser Asn Gly Ile Gln Leu Ala Gln Tyr Tyr Lys Ser Thr Lys Leu 185 190 195 gat gag tca caa ttg acg gtg gaa cct aat gag cct ggt atc agc att 739 Asp Glu Ser Gln Leu Thr Val Glu Pro Asn Glu Pro Gly Ile Ser Ile 200 205 210 atg tgg cac gcc cat gat ttc acc tgg tct tgc cta gtg cgc tat gac 787 Met Trp His Ala His Asp Phe Thr Trp Ser Cys Leu Val Arg Tyr Asp 215 220 225 gac atg aac cgt tac cct gag cat ttc agc att tct ttt aaa gac atg 835 Asp Met Asn Arg Tyr Pro Glu His Phe Ser Ile Ser Phe Lys Asp Met 230 235 240 245 ctg atc cct gaa cag atc tat act ttc cac ttc acc cca cgt gag gca 883 Leu Ile Pro Glu Gln Ile Tyr Thr Phe His Phe Thr Pro Arg Glu Ala 250 255 260 atg caa ctg cgc aag gta ctt ttt aat gcc atc gct gcc tac aag tct 931 Met Gln Leu Arg Lys Val Leu Phe Asn Ala Ile Ala Ala Tyr Lys Ser 265 270 275 cag aca tgg ggt gat gag aac act gat ctc acc aag gct gaa ctc gaa 979 Gln Thr Trp Gly Asp Glu Asn Thr Asp Leu Thr Lys Ala Glu Leu Glu 280 285 290 ttt ggt ggc acc tcc atg acc ttc cgc gcc ggc ctc tca cag ctt agc 1027 Phe Gly Gly Thr Ser Met Thr Phe Arg Ala Gly Leu Ser Gln Leu Ser 295 300 305 gtc acc gga cct cct gat cac cgc cag gtg ttc tgc ttg tcg tct tct 1075 Val Thr Gly Pro Pro Asp His Arg Gln Val Phe Cys Leu Ser Ser Ser 310 315 320 325 ggt cgt gag gat cac aac acc ccg cca aac atg cga gac gga cat gtc 1123 Gly Arg Glu Asp His Asn Thr Pro Pro Asn Met Arg Asp Gly His Val 330 335 340 att gat att gcg gtt act caa ttg tcc acc ctg cgt aac ctc att cgg 1171 Ile Asp Ile Ala Val Thr Gln Leu Ser Thr Leu Arg Asn Leu Ile Arg 345 350 355 gta ctg tgc acc act cac ccg gat cat tca cca gca ctg cta cct tat 1219 Val Leu Cys Thr Thr His Pro Asp His Ser Pro Ala Leu Leu Pro Tyr 360 365 370 ggt cag cag tac acc atc taacatgctc taactcgacc ccgaaacacc 1267 Gly Gln Gln Tyr Thr Ile 375 <210> 200 <211> 379 <212> PRT <213> Corynebacterium glutamicum <400> 200 Met Leu Tyr Gln His Thr Thr Arg Gly Leu Ile Ile Ser Asp Ala Ile 1 5 10 15 Ile Ala Lys Ile Ser Gln Val Asn Gln Leu Leu Leu Leu Arg Pro Thr 20 25 30 Leu Leu Gln Asp Lys Asp Met His His Ala Thr Leu Ser Ser Asp Thr 35 40 45 Pro Ser Ile Arg Ser Arg Arg Arg Ser Tyr Arg Glu Asn Lys Ala Ala 50 55 60 Tyr Ala Thr Thr Ser Thr Ile Arg Asn Arg Glu Thr Phe Phe Ser Thr 65 70 75 80 Ser Asp Ile Asp Phe Ala Ile Leu Met Ile Gln Asp Val Gln Glu Ser 85 90 95 Leu Val Ser Phe Asp Pro Thr Leu Ala Gln Asp Met Lys Pro Arg Thr 100 105 110 Asn Ala Val Ile Ser Ala Leu Asn Glu Leu Arg Glu Pro Leu Asp Thr 115 120 125 Phe Tyr Arg Ala His Glu Tyr Gly Asp Ile Ile Ser Asp Gly Ala Tyr 130 135 140 Glu Phe Asp His Ala Ala Ile Asp Ala Gln His Ser Leu Ser Glu Leu 145 150 155 160 Val Ala Gly Leu His Asn Tyr Asp Asn Leu Met Phe Pro Gln Glu Thr 165 170 175 Ala Pro Leu Met Ser Glu Ser Asn Gly Ile Gln Leu Ala Gln Tyr Tyr 180 185 190 Lys Ser Thr Lys Leu Asp Glu Ser Gln Leu Thr Val Glu Pro Asn Glu 195 200 205 Pro Gly Ile Ser Ile Met Trp His Ala His Asp Phe Thr Trp Ser Cys 210 215 220 Leu Val Arg Tyr Asp Asp Met Asn Arg Tyr Pro Glu His Phe Ser Ile 225 230 235 240 Ser Phe Lys Asp Met Leu Ile Pro Glu Gln Ile Tyr Thr Phe His Phe 245 250 255 Thr Pro Arg Glu Ala Met Gln Leu Arg Lys Val Leu Phe Asn Ala Ile 260 265 270 Ala Ala Tyr Lys Ser Gln Thr Trp Gly Asp Glu Asn Thr Asp Leu Thr 275 280 285 Lys Ala Glu Leu Glu Phe Gly Gly Thr Ser Met Thr Phe Arg Ala Gly 290 295 300 Leu Ser Gln Leu Ser Val Thr Gly Pro Pro Asp His Arg Gln Val Phe 305 310 315 320 Cys Leu Ser Ser Ser Gly Arg Glu Asp His Asn Thr Pro Pro Asn Met 325 330 335 Arg Asp Gly His Val Ile Asp Ile Ala Val Thr Gln Leu Ser Thr Leu 340 345 350 Arg Asn Leu Ile Arg Val Leu Cys Thr Thr His Pro Asp His Ser Pro 355 360 365 Ala Leu Leu Pro Tyr Gly Gln Gln Tyr Thr Ile 370 375 <210> 201 <211> 1549 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1519) <223> RXA01779 <400> 201 ttagtattta gtcaattagc caactacgat aaaactagtg aataaacata ctagttcact 60 ttgtcgcgct taaaatacta gaaagtaata taaaaaactc atg cgt tat act ccc 115 Met Arg Tyr Thr Pro 1 5 cgt acc cac cgc gca ctc gga ctt gct gca ctt acc gct aca gct ctc 163 Arg Thr His Arg Ala Leu Gly Leu Ala Ala Leu Thr Ala Thr Ala Leu 10 15 20 cta ctg agc tca tgc tcg acc acc gct gac ctt ctc ggc gcc gat tct 211 Leu Leu Ser Ser Cys Ser Thr Thr Ala Asp Leu Leu Gly Ala Asp Ser 25 30 35 gtg gcg cag gct gtc acc gat ggt ggc tct gcc ctt gat ccc act gca 259 Val Ala Gln Ala Val Thr Asp Gly Gly Ser Ala Leu Asp Pro Thr Ala 40 45 50 gct cat gtg ctc acc atc acc aat gcc act gca atg act ctt gct gag 307 Ala His Val Leu Thr Ile Thr Asn Ala Thr Ala Met Thr Leu Ala Glu 55 60 65 cta cca gaa aac acc gac cct gac gca gcc aat aac acg gag cca aca 355 Leu Pro Glu Asn Thr Asp Pro Asp Ala Ala Asn Asn Thr Glu Pro Thr 70 75 80 85 atg gcc caa agc gcc ctc aag cgt att tac ggt ctc gaa att gcc gcc 403 Met Ala Gln Ser Ala Leu Lys Arg Ile Tyr Gly Leu Glu Ile Ala Ala 90 95 100 gat ggc act ctg att gct gtc gca gcg cca tta acc tcg cga aat agt 451 Asp Gly Thr Leu Ile Ala Val Ala Ala Pro Leu Thr Ser Arg Asn Ser 105 110 115 ggt tct gag cag cct act gtc gca gca atg gct gat cca gaa aac aat 499 Gly Ser Glu Gln Pro Thr Val Ala Ala Met Ala Asp Pro Glu Asn Asn 120 125 130 gct gaa ctc acc aca gca cat att ctt gag atc gac cca gcc aca gga 547 Ala Glu Leu Thr Thr Ala His Ile Leu Glu Ile Asp Pro Ala Thr Gly 135 140 145 act gcc aca cca cgt caa gat att gct ctg act gaa gat ttt cag acc 595 Thr Ala Thr Pro Arg Gln Asp Ile Ala Leu Thr Glu Asp Phe Gln Thr 150 155 160 165 atg gct agc tct ttt agc cag atc cgt aat ggc tgg ggt act acc caa 643 Met Ala Ser Ser Phe Ser Gln Ile Arg Asn Gly Trp Gly Thr Thr Gln 170 175 180 ctc atc gga caa cac cct gat gat ccc aag caa cct att cgt tca gct 691 Leu Ile Gly Gln His Pro Asp Asp Pro Lys Gln Pro Ile Arg Ser Ala 185 190 195 gat acc tgg act gtc acc ggc tcc act cag atc acc ggc ttt aac acc 739 Asp Thr Trp Thr Val Thr Gly Ser Thr Gln Ile Thr Gly Phe Asn Thr 200 205 210 aac acc cca acg gga acc gaa gat gct gcc tac acc atg ccg gcg act 787 Asn Thr Pro Thr Gly Thr Glu Asp Ala Ala Tyr Thr Met Pro Ala Thr 215 220 225 gag cca gct gtg gga ctg tgc gct cta gaa tca ggc tcc gat gca cca 835 Glu Pro Ala Val Gly Leu Cys Ala Leu Glu Ser Gly Ser Asp Ala Pro 230 235 240 245 ctg gat gaa cac cgt gag ctc agc acc agt gca ttg cgt acc gca tca 883 Leu Asp Glu His Arg Glu Leu Ser Thr Ser Ala Leu Arg Thr Ala Ser 250 255 260 gta ttg tcg agc tct gga tct gcc acc ctc aag ctg cat gat cct atg 931 Val Leu Ser Ser Ser Gly Ser Ala Thr Leu Lys Leu His Asp Pro Met 265 270 275 gtc atg tct gct act ggc att gtc caa gca cgc gcc tat gtc gat ggc 979 Val Met Ser Ala Thr Gly Ile Val Gln Ala Arg Ala Tyr Val Asp Gly 280 285 290 gaa gtc att aac cag cac gag att ggc gat ctc cgc gag cag ctc ggt 1027 Glu Val Ile Asn Gln His Glu Ile Gly Asp Leu Arg Glu Gln Leu Gly 295 300 305 atc aac atc gaa gaa tct gag gct gct caa gca gaa tcg gat gcc caa 1075 Ile Asn Ile Glu Glu Ser Glu Ala Ala Gln Ala Glu Ser Asp Ala Gln 310 315 320 325 gca gcc acc gat cac cca ctt gca gcc ctg ggc tta agc aac ccc acc 1123 Ala Ala Thr Asp His Pro Leu Ala Ala Leu Gly Leu Ser Asn Pro Thr 330 335 340 agc tca gcg ttg gtt cca ggt ctt gct gag ctt gat tgt ctc agt gct 1171 Ser Ser Ala Leu Val Pro Gly Leu Ala Glu Leu Asp Cys Leu Ser Ala 345 350 355 gac cag gct gcc acc tgg cat aac cgc gac acc agc att ggc acc ggt 1219 Asp Gln Ala Ala Thr Trp His Asn Arg Asp Thr Ser Ile Gly Thr Gly 360 365 370 aag ccc agc gtg ctt gct gtc atc aac gcg gaa atg gcc gat gac ttt 1267 Lys Pro Ser Val Leu Ala Val Ile Asn Ala Glu Met Ala Asp Asp Phe 375 380 385 acc ctg cag ctg ttg agc tca ggt gcc acc act gcc gaa acg cag ctt 1315 Thr Leu Gln Leu Leu Ser Ser Gly Ala Thr Thr Ala Glu Thr Gln Leu 390 395 400 405 gcc cag ctg ccg gat gaa acc gcg ttc gtg ctc att gac cca tca tct 1363 Ala Gln Leu Pro Asp Glu Thr Ala Phe Val Leu Ile Asp Pro Ser Ser 410 415 420 ggt gct gtt act gac ctg ttc ttt atc caa agt ctc aac act gat ctg 1411 Gly Ala Val Thr Asp Leu Phe Phe Ile Gln Ser Leu Asn Thr Asp Leu 425 430 435 ccg gca cca aca acc cag att aat tct att gct gtt gat gag cgc gac 1459 Pro Ala Pro Thr Thr Gln Ile Asn Ser Ile Ala Val Asp Glu Arg Asp 440 445 450 ccc aac atc atc tac gcc act ttt agc ggc gat gac cac ctg tac caa 1507 Pro Asn Ile Ile Tyr Ala Thr Phe Ser Gly Asp Asp His Leu Tyr Gln 455 460 465 atg atg ctg ggt tagttacaca actaactaac caggcaccaa 1549 Met Met Leu Gly 470 <210> 202 <211> 473 <212> PRT <213> Corynebacterium glutamicum <400> 202 Met Arg Tyr Thr Pro Arg Thr His Arg Ala Leu Gly Leu Ala Ala Leu 1 5 10 15 Thr Ala Thr Ala Leu Leu Leu Ser Ser Cys Ser Thr Thr Ala Asp Leu 20 25 30 Leu Gly Ala Asp Ser Val Ala Gln Ala Val Thr Asp Gly Gly Ser Ala 35 40 45 Leu Asp Pro Thr Ala Ala His Val Leu Thr Ile Thr Asn Ala Thr Ala 50 55 60 Met Thr Leu Ala Glu Leu Pro Glu Asn Thr Asp Pro Asp Ala Ala Asn 65 70 75 80 Asn Thr Glu Pro Thr Met Ala Gln Ser Ala Leu Lys Arg Ile Tyr Gly 85 90 95 Leu Glu Ile Ala Ala Asp Gly Thr Leu Ile Ala Val Ala Ala Pro Leu 100 105 110 Thr Ser Arg Asn Ser Gly Ser Glu Gln Pro Thr Val Ala Ala Met Ala 115 120 125 Asp Pro Glu Asn Asn Ala Glu Leu Thr Thr Ala His Ile Leu Glu Ile 130 135 140 Asp Pro Ala Thr Gly Thr Ala Thr Pro Arg Gln Asp Ile Ala Leu Thr 145 150 155 160 Glu Asp Phe Gln Thr Met Ala Ser Ser Phe Ser Gln Ile Arg Asn Gly 165 170 175 Trp Gly Thr Thr Gln Leu Ile Gly Gln His Pro Asp Asp Pro Lys Gln 180 185 190 Pro Ile Arg Ser Ala Asp Thr Trp Thr Val Thr Gly Ser Thr Gln Ile 195 200 205 Thr Gly Phe Asn Thr Asn Thr Pro Thr Gly Thr Glu Asp Ala Ala Tyr 210 215 220 Thr Met Pro Ala Thr Glu Pro Ala Val Gly Leu Cys Ala Leu Glu Ser 225 230 235 240 Gly Ser Asp Ala Pro Leu Asp Glu His Arg Glu Leu Ser Thr Ser Ala 245 250 255 Leu Arg Thr Ala Ser Val Leu Ser Ser Ser Gly Ser Ala Thr Leu Lys 260 265 270 Leu His Asp Pro Met Val Met Ser Ala Thr Gly Ile Val Gln Ala Arg 275 280 285 Ala Tyr Val Asp Gly Glu Val Ile Asn Gln His Glu Ile Gly Asp Leu 290 295 300 Arg Glu Gln Leu Gly Ile Asn Ile Glu Glu Ser Glu Ala Ala Gln Ala 305 310 315 320 Glu Ser Asp Ala Gln Ala Ala Thr Asp His Pro Leu Ala Ala Leu Gly 325 330 335 Leu Ser Asn Pro Thr Ser Ser Ala Leu Val Pro Gly Leu Ala Glu Leu 340 345 350 Asp Cys Leu Ser Ala Asp Gln Ala Ala Thr Trp His Asn Arg Asp Thr 355 360 365 Ser Ile Gly Thr Gly Lys Pro Ser Val Leu Ala Val Ile Asn Ala Glu 370 375 380 Met Ala Asp Asp Phe Thr Leu Gln Leu Leu Ser Ser Gly Ala Thr Thr 385 390 395 400 Ala Glu Thr Gln Leu Ala Gln Leu Pro Asp Glu Thr Ala Phe Val Leu 405 410 415 Ile Asp Pro Ser Ser Gly Ala Val Thr Asp Leu Phe Phe Ile Gln Ser 420 425 430 Leu Asn Thr Asp Leu Pro Ala Pro Thr Thr Gln Ile Asn Ser Ile Ala 435 440 445 Val Asp Glu Arg Asp Pro Asn Ile Ile Tyr Ala Thr Phe Ser Gly Asp 450 455 460 Asp His Leu Tyr Gln Met Met Leu Gly 465 470 <210> 203 <211> 772 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(742) <223> RXA01789 <400> 203 tgcatcccaa caccacaaca ccgcccctag tgccataaat gctaggggtg tttttttcat 60 acccacaaca ccgttcttct ctagaaagag actcgatact atg cct cat aac ccc 115 Met Pro His Asn Pro 1 5 atc gaa ctt cac act aat gat gta ctc gat gct ctc gac att gac gcc 163 Ile Glu Leu His Thr Asn Asp Val Leu Asp Ala Leu Asp Ile Asp Ala 10 15 20 atc tgc gac gat gtg ttt ctc tac acc gac ttc gag cac acc cca ggt 211 Ile Cys Asp Asp Val Phe Leu Tyr Thr Asp Phe Glu His Thr Pro Gly 25 30 35 cag ctt gat cgc ttc gag caa ctc gcc ttc aca aaa atc tac gac atg 259 Gln Leu Asp Arg Phe Glu Gln Leu Ala Phe Thr Lys Ile Tyr Asp Met 40 45 50 ctg gaa aca gct gct gaa aaa ttc cca gat gta gca att aat gac act 307 Leu Glu Thr Ala Ala Glu Lys Phe Pro Asp Val Ala Ile Asn Asp Thr 55 60 65 tta agc act ggc aac cac gct gct gaa cag tac ttt ctt gcc aat ccc 355 Leu Ser Thr Gly Asn His Ala Ala Glu Gln Tyr Phe Leu Ala Asn Pro 70 75 80 85 ggc aac atc atc gtg ctg acc agc ttc gcg ctc aat cag acc gat ctc 403 Gly Asn Ile Ile Val Leu Thr Ser Phe Ala Leu Asn Gln Thr Asp Leu 90 95 100 cgc gac ctc ata atc tca ccg tgc att aag tac aca gca cat gca cga 451 Arg Asp Leu Ile Ile Ser Pro Cys Ile Lys Tyr Thr Ala His Ala Arg 105 110 115 gca ctc atg cgt gcg gtg aca cga aca ttg tgc act gca aac aac cct 499 Ala Leu Met Arg Ala Val Thr Arg Thr Leu Cys Thr Ala Asn Asn Pro 120 125 130 gta gaa cgc gcg act atc ttc cct gtg tct gtc gct aat gcc tta agc 547 Val Glu Arg Ala Thr Ile Phe Pro Val Ser Val Ala Asn Ala Leu Ser 135 140 145 atc gaa gcg ctg tgt tcc gaa tat cat gcg ttc cgc acc aag cag gtg 595 Ile Glu Ala Leu Cys Ser Glu Tyr His Ala Phe Arg Thr Lys Gln Val 150 155 160 165 ctc aac act gct gca ctc atc aat cct gat aac act ctt ata ccc atg 643 Leu Asn Thr Ala Ala Leu Ile Asn Pro Asp Asn Thr Leu Ile Pro Met 170 175 180 ttg ttg agc aaa gcg tat gag gca tac gcc tgg cac aag ggt gtc gaa 691 Leu Leu Ser Lys Ala Tyr Glu Ala Tyr Ala Trp His Lys Gly Val Glu 185 190 195 tcc gcg caa cga ggt agc aac cta gct cgt gag tac tac gca gga ctt 739 Ser Ala Gln Arg Gly Ser Asn Leu Ala Arg Glu Tyr Tyr Ala Gly Leu 200 205 210 atc tgaaaattca ctactcaact ctggccccaa 772 Ile <210> 204 <211> 214 <212> PRT <213> Corynebacterium glutamicum <400> 204 Met Pro His Asn Pro Ile Glu Leu His Thr Asn Asp Val Leu Asp Ala 1 5 10 15 Leu Asp Ile Asp Ala Ile Cys Asp Asp Val Phe Leu Tyr Thr Asp Phe 20 25 30 Glu His Thr Pro Gly Gln Leu Asp Arg Phe Glu Gln Leu Ala Phe Thr 35 40 45 Lys Ile Tyr Asp Met Leu Glu Thr Ala Ala Glu Lys Phe Pro Asp Val 50 55 60 Ala Ile Asn Asp Thr Leu Ser Thr Gly Asn His Ala Ala Glu Gln Tyr 65 70 75 80 Phe Leu Ala Asn Pro Gly Asn Ile Ile Val Leu Thr Ser Phe Ala Leu 85 90 95 Asn Gln Thr Asp Leu Arg Asp Leu Ile Ile Ser Pro Cys Ile Lys Tyr 100 105 110 Thr Ala His Ala Arg Ala Leu Met Arg Ala Val Thr Arg Thr Leu Cys 115 120 125 Thr Ala Asn Asn Pro Val Glu Arg Ala Thr Ile Phe Pro Val Ser Val 130 135 140 Ala Asn Ala Leu Ser Ile Glu Ala Leu Cys Ser Glu Tyr His Ala Phe 145 150 155 160 Arg Thr Lys Gln Val Leu Asn Thr Ala Ala Leu Ile Asn Pro Asp Asn 165 170 175 Thr Leu Ile Pro Met Leu Leu Ser Lys Ala Tyr Glu Ala Tyr Ala Trp 180 185 190 His Lys Gly Val Glu Ser Ala Gln Arg Gly Ser Asn Leu Ala Arg Glu 195 200 205 Tyr Tyr Ala Gly Leu Ile 210 <210> 205 <211> 493 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(463) <223> RXA01791 <400> 205 ccgcctgtgc aactaaccct gttgtgcagg cggttttctc tatctacacc aacaactcca 60 caacactatc cggtccaaat ctagaaaaga gacaaccccc atg acc tcc ccc acc 115 Met Thr Ser Pro Thr 1 5 acg tta aag ccc tgg tct att cgc gga ccc atc gac ggt gaa tac acc 163 Thr Leu Lys Pro Trp Ser Ile Arg Gly Pro Ile Asp Gly Glu Tyr Thr 10 15 20 atg ctt gag gca tat ccg ttt cag tat gta gca aat act cgc ccg gcc 211 Met Leu Glu Ala Tyr Pro Phe Gln Tyr Val Ala Asn Thr Arg Pro Ala 25 30 35 atc atg ctc tac gca ctc gat gaa aac ggt gta ccg gaa caa tat gcc 259 Ile Met Leu Tyr Ala Leu Asp Glu Asn Gly Val Pro Glu Gln Tyr Ala 40 45 50 gac ctc acc atc aac ctt gcc gat gtg gag ctc aag caa ctt aac cac 307 Asp Leu Thr Ile Asn Leu Ala Asp Val Glu Leu Lys Gln Leu Asn His 55 60 65 gtc atc att aac cca gat ctg cac gct gat gtt acc gaa ctg tgc att 355 Val Ile Ile Asn Pro Asp Leu His Ala Asp Val Thr Glu Leu Cys Ile 70 75 80 85 agc gcc ggc ctg ctg cga cct ggt gtt ctg ggc cag cac caa gtc ggt 403 Ser Ala Gly Leu Leu Arg Pro Gly Val Leu Gly Gln His Gln Val Gly 90 95 100 agc acc acc gcc aag gtc tac cga ctc act gag cgt gct gat ggc tgg 451 Ser Thr Thr Ala Lys Val Tyr Arg Leu Thr Glu Arg Ala Asp Gly Trp 105 110 115 cta cag ctg ttt tagcagctac ctgcgcctaa tccccccacc 493 Leu Gln Leu Phe 120 <210> 206 <211> 121 <212> PRT <213> Corynebacterium glutamicum <400> 206 Met Thr Ser Pro Thr Thr Leu Lys Pro Trp Ser Ile Arg Gly Pro Ile 1 5 10 15 Asp Gly Glu Tyr Thr Met Leu Glu Ala Tyr Pro Phe Gln Tyr Val Ala 20 25 30 Asn Thr Arg Pro Ala Ile Met Leu Tyr Ala Leu Asp Glu Asn Gly Val 35 40 45 Pro Glu Gln Tyr Ala Asp Leu Thr Ile Asn Leu Ala Asp Val Glu Leu 50 55 60 Lys Gln Leu Asn His Val Ile Ile Asn Pro Asp Leu His Ala Asp Val 65 70 75 80 Thr Glu Leu Cys Ile Ser Ala Gly Leu Leu Arg Pro Gly Val Leu Gly 85 90 95 Gln His Gln Val Gly Ser Thr Thr Ala Lys Val Tyr Arg Leu Thr Glu 100 105 110 Arg Ala Asp Gly Trp Leu Gln Leu Phe 115 120 <210> 207 <211> 1306 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1276) <223> RXA01809 <400> 207 acaacacgac agttgtaact agtggtttca acaccattat cggtatgact cgtggcgact 60 cgtatctctc tgatgatctc gatgacctgg gttaaacccg atg aac gag cag gaa 115 Met Asn Glu Gln Glu 1 5 cga gaa gcc tta gag gat gct gcc ctt gag gaa gct gcc tta gcc gat 163 Arg Glu Ala Leu Glu Asp Ala Ala Leu Glu Glu Ala Ala Leu Ala Asp 10 15 20 gaa tta gct gca tta gag gct gaa gct ggc gta caa ggg tca gtc gag 211 Glu Leu Ala Ala Leu Glu Ala Glu Ala Gly Val Gln Gly Ser Val Glu 25 30 35 cct tat gac tat gca gca gac ctt gat gat gag gac gag ttt gat gag 259 Pro Tyr Asp Tyr Ala Ala Asp Leu Asp Asp Glu Asp Glu Phe Asp Glu 40 45 50 gac cct ttt gct cag gat gaa ccc cgt gac gct ggt ccg cta ggt gag 307 Asp Pro Phe Ala Gln Asp Glu Pro Arg Asp Ala Gly Pro Leu Gly Glu 55 60 65 ttg agc agt gat aac cat gtc tct gag gct gtt gct gaa gac act ggg 355 Leu Ser Ser Asp Asn His Val Ser Glu Ala Val Ala Glu Asp Thr Gly 70 75 80 85 aca agt aca gaa gag tct gca caa gag ggc agt cac gaa gag tcg gta 403 Thr Ser Thr Glu Glu Ser Ala Gln Glu Gly Ser His Glu Glu Ser Val 90 95 100 gac aat ccc cgt gat ttc acc ggc act gcg aca gcg gtg cga tct ttt 451 Asp Asn Pro Arg Asp Phe Thr Gly Thr Ala Thr Ala Val Arg Ser Phe 105 110 115 cga ccc aga ctt ccc gta ccc aat gca ctg cga cca gga cca ccc atc 499 Arg Pro Arg Leu Pro Val Pro Asn Ala Leu Arg Pro Gly Pro Pro Ile 120 125 130 cga aca caa ccg gca gtg aac acc gac ata gat gat ggc ggg caa gag 547 Arg Thr Gln Pro Ala Val Asn Thr Asp Ile Asp Asp Gly Gly Gln Glu 135 140 145 aat aca gct ggc gcg act gcc gca gat gtg ggg gcg gga gtg ttt ttt 595 Asn Thr Ala Gly Ala Thr Ala Ala Asp Val Gly Ala Gly Val Phe Phe 150 155 160 165 ggt acg cat ttt gag ctg gct ttt ggg cag gtt gat gtt cac cgc cac 643 Gly Thr His Phe Glu Leu Ala Phe Gly Gln Val Asp Val His Arg His 170 175 180 ata agg cat gag cag gct atg cga gat gga cac cag gat ctc agc gtc 691 Ile Arg His Glu Gln Ala Met Arg Asp Gly His Gln Asp Leu Ser Val 185 190 195 ttt gtc ggt gct gat ggg gcg atc atg ctg gaa gaa ctt aaa aat cgt 739 Phe Val Gly Ala Asp Gly Ala Ile Met Leu Glu Glu Leu Lys Asn Arg 200 205 210 tac cag cgc cca ccg gag aac gag ccc cat gat gat gat gtc acc gaa 787 Tyr Gln Arg Pro Pro Glu Asn Glu Pro His Asp Asp Asp Val Thr Glu 215 220 225 atg ata aag acc acc gag gaa aca gag aag gag aac gta gag atg gat 835 Met Ile Lys Thr Thr Glu Glu Thr Glu Lys Glu Asn Val Glu Met Asp 230 235 240 245 cag gat ata gct gta gta gac aac gtt gat gaa cag gtt gtg gtg aca 883 Gln Asp Ile Ala Val Val Asp Asn Val Asp Glu Gln Val Val Val Thr 250 255 260 cct gct cat gac gct gac agc gta gcg gtt gtt gct gaa cag gtc gtt 931 Pro Ala His Asp Ala Asp Ser Val Ala Val Val Ala Glu Gln Val Val 265 270 275 gcg tca gaa cca acg cca gag ccg gta ccc aag gtt gag cac gta gag 979 Ala Ser Glu Pro Thr Pro Glu Pro Val Pro Lys Val Glu His Val Glu 280 285 290 atg agt gtc gat cta gcg ggt gag act att aca ccg att gat cag gca 1027 Met Ser Val Asp Leu Ala Gly Glu Thr Ile Thr Pro Ile Asp Gln Ala 295 300 305 att cgg tct ttt atg cag ctc aac ggt att gag cac agc gtg gtg ttg 1075 Ile Arg Ser Phe Met Gln Leu Asn Gly Ile Glu His Ser Val Val Leu 310 315 320 325 cga cgc ttg ggg ctg atg act cag gtg gca cat aat aag gaa ctt gat 1123 Arg Arg Leu Gly Leu Met Thr Gln Val Ala His Asn Lys Glu Leu Asp 330 335 340 gag gtc tac gct aag gca ctt gcc gag ggt gaa tcc cat gct cag cag 1171 Glu Val Tyr Ala Lys Ala Leu Ala Glu Gly Glu Ser His Ala Gln Gln 345 350 355 cag cat gaa tta gaa gca gaa aat gaa cgg ctt aaa aaa gaa gtt gat 1219 Gln His Glu Leu Glu Ala Glu Asn Glu Arg Leu Lys Lys Glu Val Asp 360 365 370 gcg ctc gct gca gag ctt agt gct gcg ttg atg ggc gag ggt ggt ggt 1267 Ala Leu Ala Ala Glu Leu Ser Ala Ala Leu Met Gly Glu Gly Gly Gly 375 380 385 gat cat gac taaggccgtg acaccaattg tggtgaccga 1306 Asp His Asp 390 <210> 208 <211> 392 <212> PRT <213> Corynebacterium glutamicum <400> 208 Met Asn Glu Gln Glu Arg Glu Ala Leu Glu Asp Ala Ala Leu Glu Glu 1 5 10 15 Ala Ala Leu Ala Asp Glu Leu Ala Ala Leu Glu Ala Glu Ala Gly Val 20 25 30 Gln Gly Ser Val Glu Pro Tyr Asp Tyr Ala Ala Asp Leu Asp Asp Glu 35 40 45 Asp Glu Phe Asp Glu Asp Pro Phe Ala Gln Asp Glu Pro Arg Asp Ala 50 55 60 Gly Pro Leu Gly Glu Leu Ser Ser Asp Asn His Val Ser Glu Ala Val 65 70 75 80 Ala Glu Asp Thr Gly Thr Ser Thr Glu Glu Ser Ala Gln Glu Gly Ser 85 90 95 His Glu Glu Ser Val Asp Asn Pro Arg Asp Phe Thr Gly Thr Ala Thr 100 105 110 Ala Val Arg Ser Phe Arg Pro Arg Leu Pro Val Pro Asn Ala Leu Arg 115 120 125 Pro Gly Pro Pro Ile Arg Thr Gln Pro Ala Val Asn Thr Asp Ile Asp 130 135 140 Asp Gly Gly Gln Glu Asn Thr Ala Gly Ala Thr Ala Ala Asp Val Gly 145 150 155 160 Ala Gly Val Phe Phe Gly Thr His Phe Glu Leu Ala Phe Gly Gln Val 165 170 175 Asp Val His Arg His Ile Arg His Glu Gln Ala Met Arg Asp Gly His 180 185 190 Gln Asp Leu Ser Val Phe Val Gly Ala Asp Gly Ala Ile Met Leu Glu 195 200 205 Glu Leu Lys Asn Arg Tyr Gln Arg Pro Pro Glu Asn Glu Pro His Asp 210 215 220 Asp Asp Val Thr Glu Met Ile Lys Thr Thr Glu Glu Thr Glu Lys Glu 225 230 235 240 Asn Val Glu Met Asp Gln Asp Ile Ala Val Val Asp Asn Val Asp Glu 245 250 255 Gln Val Val Val Thr Pro Ala His Asp Ala Asp Ser Val Ala Val Val 260 265 270 Ala Glu Gln Val Val Ala Ser Glu Pro Thr Pro Glu Pro Val Pro Lys 275 280 285 Val Glu His Val Glu Met Ser Val Asp Leu Ala Gly Glu Thr Ile Thr 290 295 300 Pro Ile Asp Gln Ala Ile Arg Ser Phe Met Gln Leu Asn Gly Ile Glu 305 310 315 320 His Ser Val Val Leu Arg Arg Leu Gly Leu Met Thr Gln Val Ala His 325 330 335 Asn Lys Glu Leu Asp Glu Val Tyr Ala Lys Ala Leu Ala Glu Gly Glu 340 345 350 Ser His Ala Gln Gln Gln His Glu Leu Glu Ala Glu Asn Glu Arg Leu 355 360 365 Lys Lys Glu Val Asp Ala Leu Ala Ala Glu Leu Ser Ala Ala Leu Met 370 375 380 Gly Glu Gly Gly Gly Asp His Asp 385 390 <210> 209 <211> 400 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(370) <223> RXA01825 <400> 209 gtcaaggtag ctggcccggc aactgatacg ttaagctcaa acaagataag taccagttgc 60 tggggttttt ccaagacaat aaattatgaa ggtgtgaaca atg cca aag gca aga 115 Met Pro Lys Ala Arg 1 5 gta act aaa aac gag acc gca ccg gtt tca agc aac cca agc gca aac 163 Val Thr Lys Asn Glu Thr Ala Pro Val Ser Ser Asn Pro Ser Ala Asn 10 15 20 cgc acc ccg gtt aag atc aat tcc gcc gga acc cca atg tgg tac aag 211 Arg Thr Pro Val Lys Ile Asn Ser Ala Gly Thr Pro Met Trp Tyr Lys 25 30 35 gtc atc atg ttt gcc ttc atg atc gtc ggc cta gcc tgg ttg atc att 259 Val Ile Met Phe Ala Phe Met Ile Val Gly Leu Ala Trp Leu Ile Ile 40 45 50 aac tac ctc gtg ggc cca cag atc cca ttc atg gct gat ctt ggt gca 307 Asn Tyr Leu Val Gly Pro Gln Ile Pro Phe Met Ala Asp Leu Gly Ala 55 60 65 tgg aac tat ggc atc ggc ttc ggt ctg atg atc atc ggc cta ctc atg 355 Trp Asn Tyr Gly Ile Gly Phe Gly Leu Met Ile Ile Gly Leu Leu Met 70 75 80 85 acc atg ggt tgg cgt taatccttca aaaaagtgac tgccgcagca 400 Thr Met Gly Trp Arg 90 <210> 210 <211> 90 <212> PRT <213> Corynebacterium glutamicum <400> 210 Met Pro Lys Ala Arg Val Thr Lys Asn Glu Thr Ala Pro Val Ser Ser 1 5 10 15 Asn Pro Ser Ala Asn Arg Thr Pro Val Lys Ile Asn Ser Ala Gly Thr 20 25 30 Pro Met Trp Tyr Lys Val Ile Met Phe Ala Phe Met Ile Val Gly Leu 35 40 45 Ala Trp Leu Ile Ile Asn Tyr Leu Val Gly Pro Gln Ile Pro Phe Met 50 55 60 Ala Asp Leu Gly Ala Trp Asn Tyr Gly Ile Gly Phe Gly Leu Met Ile 65 70 75 80 Ile Gly Leu Leu Met Thr Met Gly Trp Arg 85 90 <210> 211 <211> 1114 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1084) <223> RXA01842 <400> 211 ggcctgcgcg atagatcccc caatgtcggt ggggtccttc gtgatcactt ctttcactct 60 ttgatccacg tcatggtctc gcggtgatca tcttcctacc gtg aca ggc aag gcc 115 Val Thr Gly Lys Ala 1 5 gca aac ggc cgt gac cac agg aaa gaa att cac gag gag agg aag cac 163 Ala Asn Gly Arg Asp His Arg Lys Glu Ile His Glu Glu Arg Lys His 10 15 20 acg atg tcg aag gta tac gtg tcc aac gag tac ggc ggc ccg gaa aac 211 Thr Met Ser Lys Val Tyr Val Ser Asn Glu Tyr Gly Gly Pro Glu Asn 25 30 35 cag gaa ctg atc acc cgc aac acc ccc cag cca ggc ccg gga gaa ctc 259 Gln Glu Leu Ile Thr Arg Asn Thr Pro Gln Pro Gly Pro Gly Glu Leu 40 45 50 ggg gtc aag gtc cac gcg gcc ggg gtc aac ccg ctt gat tgg aag gtc 307 Gly Val Lys Val His Ala Ala Gly Val Asn Pro Leu Asp Trp Lys Val 55 60 65 cgt tcc ggg gtt gcc gga acc ccg cga gag ctt ccg gca ccc ctg ggc 355 Arg Ser Gly Val Ala Gly Thr Pro Arg Glu Leu Pro Ala Pro Leu Gly 70 75 80 85 gag gag gcc tcc ggg atc gtc acc gcc gtt gga gac ggt gtg gag ggc 403 Glu Glu Ala Ser Gly Ile Val Thr Ala Val Gly Asp Gly Val Glu Gly 90 95 100 ttc gcg gcc ggg gat ccg gtg ctc ggc ctg gtg gcc ccc ggc gtc ggc 451 Phe Ala Ala Gly Asp Pro Val Leu Gly Leu Val Ala Pro Gly Val Gly 105 110 115 gga tat gcc gag gac acc ctg ctg gtg gca gag agt acc gtg cta aag 499 Gly Tyr Ala Glu Asp Thr Leu Leu Val Ala Glu Ser Thr Val Leu Lys 120 125 130 ccg gag gag atc tcg ttc acc gac gcc gcc gcg atc ccg gtc gct ggg 547 Pro Glu Glu Ile Ser Phe Thr Asp Ala Ala Ala Ile Pro Val Ala Gly 135 140 145 gcg agc gcc tac gcc ggc act cac cag gtc gag ctt gaa cca ggc cag 595 Ala Ser Ala Tyr Ala Gly Thr His Gln Val Glu Leu Glu Pro Gly Gln 150 155 160 165 tcg ttg ctg atc aat ggg gcc ggt ggt ggg gtc ggg ctg atg gcc gcg 643 Ser Leu Leu Ile Asn Gly Ala Gly Gly Gly Val Gly Leu Met Ala Ala 170 175 180 cag atc gga cgg gtc cac aag ttc cag gtc gtc ggc gtt gac cac gag 691 Gln Ile Gly Arg Val His Lys Phe Gln Val Val Gly Val Asp His Glu 185 190 195 gac aag cgc gag ctc atc gaa tcc acc ggt gct atc ttc gtc gcc acc 739 Asp Lys Arg Glu Leu Ile Glu Ser Thr Gly Ala Ile Phe Val Ala Thr 200 205 210 ggc gac gcc gtc gcg gag cag gtg cgt gcg ctg ctc cct gac ggt gtg 787 Gly Asp Ala Val Ala Glu Gln Val Arg Ala Leu Leu Pro Asp Gly Val 215 220 225 gac gta gtc ttc gac cta gtc ggc ggg gag gcg ttg cgg gtg gtt gct 835 Asp Val Val Phe Asp Leu Val Gly Gly Glu Ala Leu Arg Val Val Ala 230 235 240 245 ccc tta gcg aag aat ccg gcg cac gtg atc tcg gcg gct gat gct gcc 883 Pro Leu Ala Lys Asn Pro Ala His Val Ile Ser Ala Ala Asp Ala Ala 250 255 260 acc gtg gga gaa ctc ggt gga cag gtg ctg cgc cgc acc ccg gaa atg 931 Thr Val Gly Glu Leu Gly Gly Gln Val Leu Arg Arg Thr Pro Glu Met 265 270 275 gtc gga cag atc acc ggg gtg gtc cag tac ggg ctg gtc gac ccg aag 979 Val Gly Gln Ile Thr Gly Val Val Gln Tyr Gly Leu Val Asp Pro Lys 280 285 290 gtc gat acg acc tac ccg ctg gaa cag gcc ggt aag gcc ctg gcc cac 1027 Val Asp Thr Thr Tyr Pro Leu Glu Gln Ala Gly Lys Ala Leu Ala His 295 300 305 gtt gag cag ggc cac gcc cgc ggc aag atc gtc ctc gag ctc atc acc 1075 Val Glu Gln Gly His Ala Arg Gly Lys Ile Val Leu Glu Leu Ile Thr 310 315 320 325 tcc cag gac taaccagaca acgcggtgac ctccctcagg 1114 Ser Gln Asp <210> 212 <211> 328 <212> PRT <213> Corynebacterium glutamicum <400> 212 Val Thr Gly Lys Ala Ala Asn Gly Arg Asp His Arg Lys Glu Ile His 1 5 10 15 Glu Glu Arg Lys His Thr Met Ser Lys Val Tyr Val Ser Asn Glu Tyr 20 25 30 Gly Gly Pro Glu Asn Gln Glu Leu Ile Thr Arg Asn Thr Pro Gln Pro 35 40 45 Gly Pro Gly Glu Leu Gly Val Lys Val His Ala Ala Gly Val Asn Pro 50 55 60 Leu Asp Trp Lys Val Arg Ser Gly Val Ala Gly Thr Pro Arg Glu Leu 65 70 75 80 Pro Ala Pro Leu Gly Glu Glu Ala Ser Gly Ile Val Thr Ala Val Gly 85 90 95 Asp Gly Val Glu Gly Phe Ala Ala Gly Asp Pro Val Leu Gly Leu Val 100 105 110 Ala Pro Gly Val Gly Gly Tyr Ala Glu Asp Thr Leu Leu Val Ala Glu 115 120 125 Ser Thr Val Leu Lys Pro Glu Glu Ile Ser Phe Thr Asp Ala Ala Ala 130 135 140 Ile Pro Val Ala Gly Ala Ser Ala Tyr Ala Gly Thr His Gln Val Glu 145 150 155 160 Leu Glu Pro Gly Gln Ser Leu Leu Ile Asn Gly Ala Gly Gly Gly Val 165 170 175 Gly Leu Met Ala Ala Gln Ile Gly Arg Val His Lys Phe Gln Val Val 180 185 190 Gly Val Asp His Glu Asp Lys Arg Glu Leu Ile Glu Ser Thr Gly Ala 195 200 205 Ile Phe Val Ala Thr Gly Asp Ala Val Ala Glu Gln Val Arg Ala Leu 210 215 220 Leu Pro Asp Gly Val Asp Val Val Phe Asp Leu Val Gly Gly Glu Ala 225 230 235 240 Leu Arg Val Val Ala Pro Leu Ala Lys Asn Pro Ala His Val Ile Ser 245 250 255 Ala Ala Asp Ala Ala Thr Val Gly Glu Leu Gly Gly Gln Val Leu Arg 260 265 270 Arg Thr Pro Glu Met Val Gly Gln Ile Thr Gly Val Val Gln Tyr Gly 275 280 285 Leu Val Asp Pro Lys Val Asp Thr Thr Tyr Pro Leu Glu Gln Ala Gly 290 295 300 Lys Ala Leu Ala His Val Glu Gln Gly His Ala Arg Gly Lys Ile Val 305 310 315 320 Leu Glu Leu Ile Thr Ser Gln Asp 325 <210> 213 <211> 916 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(886) <223> RXA01899 <400> 213 cctcgcagca cttcgcgcag gcgaatccac agtggccgca accttgatca aagaacacat 60 cgaaggctac tacgaagaaa ccgctgccgc cgaggcctaa atg tcc cgc act ctg 115 Met Ser Arg Thr Leu 1 5 tgg gcg gtt tca gat cta cac gtc acc ttc gcc caa aac caa aac acc 163 Trp Ala Val Ser Asp Leu His Val Thr Phe Ala Gln Asn Gln Asn Thr 10 15 20 gtt gat gcc ctc atg ccg cag gac ccc ggc gac tgg ctg atc gtc gct 211 Val Asp Ala Leu Met Pro Gln Asp Pro Gly Asp Trp Leu Ile Val Ala 25 30 35 ggc gat gta gca gag aaa atc ccc gat gtg gta cgt acc tta tcc gcg 259 Gly Asp Val Ala Glu Lys Ile Pro Asp Val Val Arg Thr Leu Ser Ala 40 45 50 ctg gtc aaa cgc ttt gac acc gtg att tgg gtg ccg ggc aac cac gaa 307 Leu Val Lys Arg Phe Asp Thr Val Ile Trp Val Pro Gly Asn His Glu 55 60 65 ctc ttc aac cgg aaa aca gac cgc gtc aac ggc aaa gcc cgc tac cga 355 Leu Phe Asn Arg Lys Thr Asp Arg Val Asn Gly Lys Ala Arg Tyr Arg 70 75 80 85 gca tta gtc gga caa ctc cga gcc atc ggc gtg atc acc ccc gaa gat 403 Ala Leu Val Gly Gln Leu Arg Ala Ile Gly Val Ile Thr Pro Glu Asp 90 95 100 ccc tat ccg atc ttt ggt ggc gtc acc atc tgc cca ctt ttc aca ctt 451 Pro Tyr Pro Ile Phe Gly Gly Val Thr Ile Cys Pro Leu Phe Thr Leu 105 110 115 tac gat tac tct ttc cgt ccc ctc ggc ctc acc gcg aaa caa gcc ctc 499 Tyr Asp Tyr Ser Phe Arg Pro Leu Gly Leu Thr Ala Lys Gln Ala Leu 120 125 130 gcc caa gca aaa ata aag cta gac gac gaa cta gcc atc gcc ccc tac 547 Ala Gln Ala Lys Ile Lys Leu Asp Asp Glu Leu Ala Ile Ala Pro Tyr 135 140 145 gta gac atc ccc gcc tgg tgc gcc gaa cga gtc acc tac aca gaa gac 595 Val Asp Ile Pro Ala Trp Cys Ala Glu Arg Val Thr Tyr Thr Glu Asp 150 155 160 165 cgc cta aaa gcc acc aaa ggc cca aaa gtc ctg gtc aat cac tgg ccg 643 Arg Leu Lys Ala Thr Lys Gly Pro Lys Val Leu Val Asn His Trp Pro 170 175 180 ctg gtc att gag ccc acc cac cgg ctc ttc caa aaa gac atc gcg ctg 691 Leu Val Ile Glu Pro Thr His Arg Leu Phe Gln Lys Asp Ile Ala Leu 185 190 195 tgg tgt gga acc acc gcc acc agg gat tgg gcc gta cga ttc aac gct 739 Trp Cys Gly Thr Thr Ala Thr Arg Asp Trp Ala Val Arg Phe Asn Ala 200 205 210 ctc atg gcc att cac ggt cac cta cat att cct gcc gaa acc cgc gtt 787 Leu Met Ala Ile His Gly His Leu His Ile Pro Ala Glu Thr Arg Val 215 220 225 gat ggg gta agc cac gtg gag gtt tct ttg ggt tac ccc ttt gaa aaa 835 Asp Gly Val Ser His Val Glu Val Ser Leu Gly Tyr Pro Phe Glu Lys 230 235 240 245 cac cca cct cac atg aag cgt ccg tgg ccg ttt ccg gtc atg cag att 883 His Pro Pro His Met Lys Arg Pro Trp Pro Phe Pro Val Met Gln Ile 250 255 260 aac taactctgtt gcttaaatgg gggtaattgg 916 Asn <210> 214 <211> 262 <212> PRT <213> Corynebacterium glutamicum <400> 214 Met Ser Arg Thr Leu Trp Ala Val Ser Asp Leu His Val Thr Phe Ala 1 5 10 15 Gln Asn Gln Asn Thr Val Asp Ala Leu Met Pro Gln Asp Pro Gly Asp 20 25 30 Trp Leu Ile Val Ala Gly Asp Val Ala Glu Lys Ile Pro Asp Val Val 35 40 45 Arg Thr Leu Ser Ala Leu Val Lys Arg Phe Asp Thr Val Ile Trp Val 50 55 60 Pro Gly Asn His Glu Leu Phe Asn Arg Lys Thr Asp Arg Val Asn Gly 65 70 75 80 Lys Ala Arg Tyr Arg Ala Leu Val Gly Gln Leu Arg Ala Ile Gly Val 85 90 95 Ile Thr Pro Glu Asp Pro Tyr Pro Ile Phe Gly Gly Val Thr Ile Cys 100 105 110 Pro Leu Phe Thr Leu Tyr Asp Tyr Ser Phe Arg Pro Leu Gly Leu Thr 115 120 125 Ala Lys Gln Ala Leu Ala Gln Ala Lys Ile Lys Leu Asp Asp Glu Leu 130 135 140 Ala Ile Ala Pro Tyr Val Asp Ile Pro Ala Trp Cys Ala Glu Arg Val 145 150 155 160 Thr Tyr Thr Glu Asp Arg Leu Lys Ala Thr Lys Gly Pro Lys Val Leu 165 170 175 Val Asn His Trp Pro Leu Val Ile Glu Pro Thr His Arg Leu Phe Gln 180 185 190 Lys Asp Ile Ala Leu Trp Cys Gly Thr Thr Ala Thr Arg Asp Trp Ala 195 200 205 Val Arg Phe Asn Ala Leu Met Ala Ile His Gly His Leu His Ile Pro 210 215 220 Ala Glu Thr Arg Val Asp Gly Val Ser His Val Glu Val Ser Leu Gly 225 230 235 240 Tyr Pro Phe Glu Lys His Pro Pro His Met Lys Arg Pro Trp Pro Phe 245 250 255 Pro Val Met Gln Ile Asn 260 <210> 215 <211> 661 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(631) <223> RXA01905 <400> 215 aaatgaaagt cacaaacttt gttggggttt ctttaaagta aaatacagaa gtttctctgg 60 caaaaaacct cactactttc tacagaaagg cgtcttcctc atg aag gct tct cag 115 Met Lys Ala Ser Gln 1 5 acc ctc acc cgc aac act cgt gca cgc aag ctc ggc atg ggt att ctc 163 Thr Leu Thr Arg Asn Thr Arg Ala Arg Lys Leu Gly Met Gly Ile Leu 10 15 20 gca gca act att atg gct acc ggt gca ctt gct ggc act gct cca cag 211 Ala Ala Thr Ile Met Ala Thr Gly Ala Leu Ala Gly Thr Ala Pro Gln 25 30 35 gcg aca gca gca gta gat acc act gcg cca tac gtg tcc tat gtc gtt 259 Ala Thr Ala Ala Val Asp Thr Thr Ala Pro Tyr Val Ser Tyr Val Val 40 45 50 gac att cct ggc aag gtt ggt gaa cca atc aag cct cag tac ctc acc 307 Asp Ile Pro Gly Lys Val Gly Glu Pro Ile Lys Pro Gln Tyr Leu Thr 55 60 65 atc tcc gat cag tcc gcc tac acc gtg acc ttc aag tac atg cca tcc 355 Ile Ser Asp Gln Ser Ala Tyr Thr Val Thr Phe Lys Tyr Met Pro Ser 70 75 80 85 tgg ttg aag tac gac gca aac aag aag atg ctg tac ggt acc cca acc 403 Trp Leu Lys Tyr Asp Ala Asn Lys Lys Met Leu Tyr Gly Thr Pro Thr 90 95 100 gag gtt gat gtc tgg act cct gag gta cat gtt gtt gat gct cat ggc 451 Glu Val Asp Val Trp Thr Pro Glu Val His Val Val Asp Ala His Gly 105 110 115 aac aag act gtc cgt tac ttc acc gtt gta gca gtc cca gca aac act 499 Asn Lys Thr Val Arg Tyr Phe Thr Val Val Ala Val Pro Ala Asn Thr 120 125 130 gca cca acc acc acc acg cca tct act cca aag cca tct acc ccg cag 547 Ala Pro Thr Thr Thr Thr Pro Ser Thr Pro Lys Pro Ser Thr Pro Gln 135 140 145 gtg acc acc cca act act ccg aag gcg cct acc ttg cca aag tcc acc 595 Val Thr Thr Pro Thr Thr Pro Lys Ala Pro Thr Leu Pro Lys Ser Thr 150 155 160 165 ttc gac tgg acc ttg tgg ggc tcc atc ttt ggt ttc tagttctcac 641 Phe Asp Trp Thr Leu Trp Gly Ser Ile Phe Gly Phe 170 175 tagcacctca aaaagcacca 661 <210> 216 <211> 177 <212> PRT <213> Corynebacterium glutamicum <400> 216 Met Lys Ala Ser Gln Thr Leu Thr Arg Asn Thr Arg Ala Arg Lys Leu 1 5 10 15 Gly Met Gly Ile Leu Ala Ala Thr Ile Met Ala Thr Gly Ala Leu Ala 20 25 30 Gly Thr Ala Pro Gln Ala Thr Ala Ala Val Asp Thr Thr Ala Pro Tyr 35 40 45 Val Ser Tyr Val Val Asp Ile Pro Gly Lys Val Gly Glu Pro Ile Lys 50 55 60 Pro Gln Tyr Leu Thr Ile Ser Asp Gln Ser Ala Tyr Thr Val Thr Phe 65 70 75 80 Lys Tyr Met Pro Ser Trp Leu Lys Tyr Asp Ala Asn Lys Lys Met Leu 85 90 95 Tyr Gly Thr Pro Thr Glu Val Asp Val Trp Thr Pro Glu Val His Val 100 105 110 Val Asp Ala His Gly Asn Lys Thr Val Arg Tyr Phe Thr Val Val Ala 115 120 125 Val Pro Ala Asn Thr Ala Pro Thr Thr Thr Thr Pro Ser Thr Pro Lys 130 135 140 Pro Ser Thr Pro Gln Val Thr Thr Pro Thr Thr Pro Lys Ala Pro Thr 145 150 155 160 Leu Pro Lys Ser Thr Phe Asp Trp Thr Leu Trp Gly Ser Ile Phe Gly 165 170 175 Phe <210> 217 <211> 976 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(946) <223> RXA01910 <400> 217 accgttttaa aaggcgcaat acaccacacc ccaacaaact ttttgattgt tggggtgttt 60 gtctcagatc atgaacagca caatgtagga gaagattgat atg gca ttt ccg ctt 115 Met Ala Phe Pro Leu 1 5 cta gcg gtt gct ggc aca gtt gcc ccc gtt gca gca gga tgg gca aaa 163 Leu Ala Val Ala Gly Thr Val Ala Pro Val Ala Ala Gly Trp Ala Lys 10 15 20 gat aag ttt ctc agc aac tct cag aat aat cag cag gcc cag aat cag 211 Asp Lys Phe Leu Ser Asn Ser Gln Asn Asn Gln Gln Ala Gln Asn Gln 25 30 35 cag atg agt ttt gga cag gtc aac aac agc gca cag aat tct gga tca 259 Gln Met Ser Phe Gly Gln Val Asn Asn Ser Ala Gln Asn Ser Gly Ser 40 45 50 gaa aac agc ggt ttc atg ggt caa tac ggc aat ctg ggt gca ggt ttg 307 Glu Asn Ser Gly Phe Met Gly Gln Tyr Gly Asn Leu Gly Ala Gly Leu 55 60 65 gca ggt gct gct aca ggc gca ggg ctt gcg tat agc gat ttt gaa gat 355 Ala Gly Ala Ala Thr Gly Ala Gly Leu Ala Tyr Ser Asp Phe Glu Asp 70 75 80 85 ggt caa agt ttg tcc tcg aag gcc cgc aac atg gtc ggc aaa ggg ctc 403 Gly Gln Ser Leu Ser Ser Lys Ala Arg Asn Met Val Gly Lys Gly Leu 90 95 100 gct ggt gcc gga gct ggt gtg ttc acc aag ctt gcc aat gat gca att 451 Ala Gly Ala Gly Ala Gly Val Phe Thr Lys Leu Ala Asn Asp Ala Ile 105 110 115 cag gcc gag ggt ggc tcg atg aag gct agt gct tat tct gcc att gca 499 Gln Ala Glu Gly Gly Ser Met Lys Ala Ser Ala Tyr Ser Ala Ile Ala 120 125 130 ggc ggc ttg gga tcg tat ctc aaa gac ggc ggt ccg ggt gtg att aaa 547 Gly Gly Leu Gly Ser Tyr Leu Lys Asp Gly Gly Pro Gly Val Ile Lys 135 140 145 tcc gcg atg gcc agc ggt gca gcc ggt ttt ggt gcg gat aaa gtg cac 595 Ser Ala Met Ala Ser Gly Ala Ala Gly Phe Gly Ala Asp Lys Val His 150 155 160 165 gat aaa tta gct gag tct ggt cat gag ggg ttg gct gat tcc ttg tcg 643 Asp Lys Leu Ala Glu Ser Gly His Glu Gly Leu Ala Asp Ser Leu Ser 170 175 180 ggc gct att caa gga ggt ggt ctt ggt tac tcc acg ctt ggc ggt gtc 691 Gly Ala Ile Gln Gly Gly Gly Leu Gly Tyr Ser Thr Leu Gly Gly Val 185 190 195 act ggt gct ggt att ggc ggt gcg acg ggc ggt ctc gca gga cta gca 739 Thr Gly Ala Gly Ile Gly Gly Ala Thr Gly Gly Leu Ala Gly Leu Ala 200 205 210 caa aac tac ttt ggt ggt ggc gat gac tac agc aac gct ggg gca tct 787 Gln Asn Tyr Phe Gly Gly Gly Asp Asp Tyr Ser Asn Ala Gly Ala Ser 215 220 225 gca tcg ggg ttt agt gcc aac cag gtt aat agt gag atc agc acc gag 835 Ala Ser Gly Phe Ser Ala Asn Gln Val Asn Ser Glu Ile Ser Thr Glu 230 235 240 245 att ccg cag ttt gcg aat ctt ggt caa cca cag cga tcc gag ctt gaa 883 Ile Pro Gln Phe Ala Asn Leu Gly Gln Pro Gln Arg Ser Glu Leu Glu 250 255 260 caa tta gcg cta cct caa gaa tca cgg tct gta gat aag agc tac gac 931 Gln Leu Ala Leu Pro Gln Glu Ser Arg Ser Val Asp Lys Ser Tyr Asp 265 270 275 caa ggc tac gaa gcg taagcgcttt ataacaaccc cgttttcagc 976 Gln Gly Tyr Glu Ala 280 <210> 218 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 218 Met Ala Phe Pro Leu Leu Ala Val Ala Gly Thr Val Ala Pro Val Ala 1 5 10 15 Ala Gly Trp Ala Lys Asp Lys Phe Leu Ser Asn Ser Gln Asn Asn Gln 20 25 30 Gln Ala Gln Asn Gln Gln Met Ser Phe Gly Gln Val Asn Asn Ser Ala 35 40 45 Gln Asn Ser Gly Ser Glu Asn Ser Gly Phe Met Gly Gln Tyr Gly Asn 50 55 60 Leu Gly Ala Gly Leu Ala Gly Ala Ala Thr Gly Ala Gly Leu Ala Tyr 65 70 75 80 Ser Asp Phe Glu Asp Gly Gln Ser Leu Ser Ser Lys Ala Arg Asn Met 85 90 95 Val Gly Lys Gly Leu Ala Gly Ala Gly Ala Gly Val Phe Thr Lys Leu 100 105 110 Ala Asn Asp Ala Ile Gln Ala Glu Gly Gly Ser Met Lys Ala Ser Ala 115 120 125 Tyr Ser Ala Ile Ala Gly Gly Leu Gly Ser Tyr Leu Lys Asp Gly Gly 130 135 140 Pro Gly Val Ile Lys Ser Ala Met Ala Ser Gly Ala Ala Gly Phe Gly 145 150 155 160 Ala Asp Lys Val His Asp Lys Leu Ala Glu Ser Gly His Glu Gly Leu 165 170 175 Ala Asp Ser Leu Ser Gly Ala Ile Gln Gly Gly Gly Leu Gly Tyr Ser 180 185 190 Thr Leu Gly Gly Val Thr Gly Ala Gly Ile Gly Gly Ala Thr Gly Gly 195 200 205 Leu Ala Gly Leu Ala Gln Asn Tyr Phe Gly Gly Gly Asp Asp Tyr Ser 210 215 220 Asn Ala Gly Ala Ser Ala Ser Gly Phe Ser Ala Asn Gln Val Asn Ser 225 230 235 240 Glu Ile Ser Thr Glu Ile Pro Gln Phe Ala Asn Leu Gly Gln Pro Gln 245 250 255 Arg Ser Glu Leu Glu Gln Leu Ala Leu Pro Gln Glu Ser Arg Ser Val 260 265 270 Asp Lys Ser Tyr Asp Gln Gly Tyr Glu Ala 275 280 <210> 219 <211> 4432 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(4402) <223> RXA01945 <400> 219 attggatcta ggaaaaatta tgaacatctc aaagctcgga ctgaggatcg cggtcacagc 60 aacggcgacc acaacggcgc ttgccctcgg tggcacgcac atg gca gtt ggt caa 115 Met Ala Val Gly Gln 1 5 gaa act gat ctg ctc aac gct atg gaa aca ctc gct ggg gtt ccc tca 163 Glu Thr Asp Leu Leu Asn Ala Met Glu Thr Leu Ala Gly Val Pro Ser 10 15 20 gac ttg gtg gtc act gaa atc ctc ccc gat acc acc agc tat gac aat 211 Asp Leu Val Val Thr Glu Ile Leu Pro Asp Thr Thr Ser Tyr Asp Asn 25 30 35 ttt gaa ttc ttt gaa gtt cac aac acc ggc agt gca ccc gtg acc att 259 Phe Glu Phe Phe Glu Val His Asn Thr Gly Ser Ala Pro Val Thr Ile 40 45 50 ggg gaa ggg gag tac acc ttc gcc tat tcc ttt gac gat tcc gcc gat 307 Gly Glu Gly Glu Tyr Thr Phe Ala Tyr Ser Phe Asp Asp Ser Ala Asp 55 60 65 acg tcc cgc gac aag gca ctg gat ctt ggc ggg gaa gtc acg gta gat 355 Thr Ser Arg Asp Lys Ala Leu Asp Leu Gly Gly Glu Val Thr Val Asp 70 75 80 85 gca ggc gaa acc att gtg gtg tgg att gag tac tcc agt tca act gtt 403 Ala Gly Glu Thr Ile Val Val Trp Ile Glu Tyr Ser Ser Ser Thr Val 90 95 100 gat acc gct gcg ttt agt gag caa gac ttc cgt gat ttc tac ggc atg 451 Asp Thr Ala Ala Phe Ser Glu Gln Asp Phe Arg Asp Phe Tyr Gly Met 105 110 115 gat tcc tca gcc cgc atc ttc cga gca act ggc cag gcg ggt ctc gct 499 Asp Ser Ser Ala Arg Ile Phe Arg Ala Thr Gly Gln Ala Gly Leu Ala 120 125 130 aac ggt ggt gat cgt ggc atc cga gtt ctg tac aat ggt gaa gtt tct 547 Asn Gly Gly Asp Arg Gly Ile Arg Val Leu Tyr Asn Gly Glu Val Ser 135 140 145 ggt tgg tcc cac tac cca tca gat agc gca gcg gtt caa aag gga att 595 Gly Trp Ser His Tyr Pro Ser Asp Ser Ala Ala Val Gln Lys Gly Ile 150 155 160 165 gac ttc gcg ctg cca aaa gta ggg gag cag gcc agc att gca gtg cgc 643 Asp Phe Ala Leu Pro Lys Val Gly Glu Gln Ala Ser Ile Ala Val Arg 170 175 180 acc aaa act gat cca act cca gga tca att act tct gat cag ttg att 691 Thr Lys Thr Asp Pro Thr Pro Gly Ser Ile Thr Ser Asp Gln Leu Ile 185 190 195 cct ggc gga ttg gac act cca gaa gag cct gaa gcc cct gaa gac tct 739 Pro Gly Gly Leu Asp Thr Pro Glu Glu Pro Glu Ala Pro Glu Asp Ser 200 205 210 ctt ttt gaa ggg cgc act ccc cct agg gat gca gca ccg ctg atc ctc 787 Leu Phe Glu Gly Arg Thr Pro Pro Arg Asp Ala Ala Pro Leu Ile Leu 215 220 225 act gaa cta atg gtc aac tcc acc aac atg ggc agt tct gat ggt ttt 835 Thr Glu Leu Met Val Asn Ser Thr Asn Met Gly Ser Ser Asp Gly Phe 230 235 240 245 gag tat gtg gaa atc acc aac act act gcc gaa ccc atc gat ttt tcc 883 Glu Tyr Val Glu Ile Thr Asn Thr Thr Ala Glu Pro Ile Asp Phe Ser 250 255 260 gat tac acc ttg aac tac ctg tac ccg cag gat gag ttc acc aac acc 931 Asp Tyr Thr Leu Asn Tyr Leu Tyr Pro Gln Asp Glu Phe Thr Asn Thr 265 270 275 aac gaa gcc gtc tgg gct gcg gaa cct ggt gat gtc att att cag cct 979 Asn Glu Ala Val Trp Ala Ala Glu Pro Gly Asp Val Ile Ile Gln Pro 280 285 290 gga aaa tct ctc gtg ttt tgg atc aaa aat ggc ccc aat gat gag gca 1027 Gly Lys Ser Leu Val Phe Trp Ile Lys Asn Gly Pro Asn Asp Glu Ala 295 300 305 acc gca gca gat ttc aat gca gaa tat ggc acc aac ctg gag gct gga 1075 Thr Ala Ala Asp Phe Asn Ala Glu Tyr Gly Thr Asn Leu Glu Ala Gly 310 315 320 325 aaa gac ctt gtt gaa atc tcc tca ggt ggg atg gcc aat ggt act gcc 1123 Lys Asp Leu Val Glu Ile Ser Ser Gly Gly Met Ala Asn Gly Thr Ala 330 335 340 aga gga atg cag att cag acc aac act ggc cac ata gtc aac cgt ggt 1171 Arg Gly Met Gln Ile Gln Thr Asn Thr Gly His Ile Val Asn Arg Gly 345 350 355 ttc tac aac atg gct ggc gct tct gat gtg aaa gcc aac gag ggt ctt 1219 Phe Tyr Asn Met Ala Gly Ala Ser Asp Val Lys Ala Asn Glu Gly Leu 360 365 370 cat ttc gca gtg gat gag tct gat ctt ctg aag caa acg ctt gtc ggc 1267 His Phe Ala Val Asp Glu Ser Asp Leu Leu Lys Gln Thr Leu Val Gly 375 380 385 agc ggt gcg cca acc ccg ggc act gtg tac act tcg cag att cct aat 1315 Ser Gly Ala Pro Thr Pro Gly Thr Val Tyr Thr Ser Gln Ile Pro Asn 390 395 400 405 cca ctg tct gcc gtt atc gct gat tct tct gta cca ctc atc aca gat 1363 Pro Leu Ser Ala Val Ile Ala Asp Ser Ser Val Pro Leu Ile Thr Asp 410 415 420 aat acc gca acc agt atc aac cct gcg gag ccg ttt acc ttc gcc ttc 1411 Asn Thr Ala Thr Ser Ile Asn Pro Ala Glu Pro Phe Thr Phe Ala Phe 425 430 435 aat atc acc gat gat gtc cag gtg cgc acg gca aca ctg cat gtt act 1459 Asn Ile Thr Asp Asp Val Gln Val Arg Thr Ala Thr Leu His Val Thr 440 445 450 tcc agt gct ggc gaa gcc gcg aca acc atc aac ctc acc gag gat gac 1507 Ser Ser Ala Gly Glu Ala Ala Thr Thr Ile Asn Leu Thr Glu Asp Asp 455 460 465 ggc tct ttc aat tgg gct ctg cct gca gcg gat ctc acc gga aaa tcc 1555 Gly Ser Phe Asn Trp Ala Leu Pro Ala Ala Asp Leu Thr Gly Lys Ser 470 475 480 485 tgg ttc gaa tac acc gta acc gcc acc gac gga ttc aac agc gtt acc 1603 Trp Phe Glu Tyr Thr Val Thr Ala Thr Asp Gly Phe Asn Ser Val Thr 490 495 500 acc gag ccg gta cgc gtc acc gtc gac ggc gcc aac acc gac ccg ctg 1651 Thr Glu Pro Val Arg Val Thr Val Asp Gly Ala Asn Thr Asp Pro Leu 505 510 515 cgc ctc aac ctg gaa gaa aac caa tgg gtc agt ggc acc acc gat gtt 1699 Arg Leu Asn Leu Glu Glu Asn Gln Trp Val Ser Gly Thr Thr Asp Val 520 525 530 atc ggt gct tca gat gtc ttc ggc gac aag ctt gaa ttg ctt atc gac 1747 Ile Gly Ala Ser Asp Val Phe Gly Asp Lys Leu Glu Leu Leu Ile Asp 535 540 545 gac gcg cct gca gtc acc aac tcc agc ctg tct gcg gcc ccg acg ttt 1795 Asp Ala Pro Ala Val Thr Asn Ser Ser Leu Ser Ala Ala Pro Thr Phe 550 555 560 565 gcg atg gaa gta acc caa act gat gtg ttc ttc cgc aac ggc atc ctt 1843 Ala Met Glu Val Thr Gln Thr Asp Val Phe Phe Arg Asn Gly Ile Leu 570 575 580 gcc ggt ggg gaa gaa ctc cgc att ttc gat caa gga act tac gcc aac 1891 Ala Gly Gly Glu Glu Leu Arg Ile Phe Asp Gln Gly Thr Tyr Ala Asn 585 590 595 acc gaa acc atc tcc aca cca gtc ccg ctg tat cac atc aat gag gac 1939 Thr Glu Thr Ile Ser Thr Pro Val Pro Leu Tyr His Ile Asn Glu Asp 600 605 610 ggt acc ctc aca gtc agt gtg tat gcg gga act aaa gca gca cca gaa 1987 Gly Thr Leu Thr Val Ser Val Tyr Ala Gly Thr Lys Ala Ala Pro Glu 615 620 625 att gac ctc aac gag aac aat gac gat ttc cag atc aga aac ctt cga 2035 Ile Asp Leu Asn Glu Asn Asn Asp Asp Phe Gln Ile Arg Asn Leu Arg 630 635 640 645 cta att ctg cct gat ggc cgg acc ctc acc cct gcc gga att tcc gat 2083 Leu Ile Leu Pro Asp Gly Arg Thr Leu Thr Pro Ala Gly Ile Ser Asp 650 655 660 tct aat gcg tgg ctc aac atg gga gac agc gct gga aaa ctc gat ttc 2131 Ser Asn Ala Trp Leu Asn Met Gly Asp Ser Ala Gly Lys Leu Asp Phe 665 670 675 ttc gat gcc acc ttc gcc ctc cct gag gat gct ttc acc ggt gtg gca 2179 Phe Asp Ala Thr Phe Ala Leu Pro Glu Asp Ala Phe Thr Gly Val Ala 680 685 690 cac gca tgg gat acc acc caa agc aca gat gga gaa cac cac atc acc 2227 His Ala Trp Asp Thr Thr Gln Ser Thr Asp Gly Glu His His Ile Thr 695 700 705 att tcc cgc gaa gac ggc ggg gaa atc agc cgc acc atc cgg gtt gat 2275 Ile Ser Arg Glu Asp Gly Gly Glu Ile Ser Arg Thr Ile Arg Val Asp 710 715 720 725 aat act gcc cca gaa ctc acc gtt tct gga gtt gaa gaa gga caa gaa 2323 Asn Thr Ala Pro Glu Leu Thr Val Ser Gly Val Glu Glu Gly Gln Glu 730 735 740 ctg cgc ggc acc gta gaa att gat gcc cag gca acc gat gcg ggt gcg 2371 Leu Arg Gly Thr Val Glu Ile Asp Ala Gln Ala Thr Asp Ala Gly Ala 745 750 755 ggc gtg aag agc gtc gag acg ctt ctc gac ggc gaa cgc gtg caa ctt 2419 Gly Val Lys Ser Val Glu Thr Leu Leu Asp Gly Glu Arg Val Gln Leu 760 765 770 cca cta acc acc ggt tcc atc gct ttg gat aaa ggt gaa cac acc ttg 2467 Pro Leu Thr Thr Gly Ser Ile Ala Leu Asp Lys Gly Glu His Thr Leu 775 780 785 gtt atc cgt gca gaa gat gaa gta gga aac cgc acc gag aaa acc atc 2515 Val Ile Arg Ala Glu Asp Glu Val Gly Asn Arg Thr Glu Lys Thr Ile 790 795 800 805 acg ttt agc act ccg gat gaa aac ccc atc agt ggt gac tac gct cca 2563 Thr Phe Ser Thr Pro Asp Glu Asn Pro Ile Ser Gly Asp Tyr Ala Pro 810 815 820 agc aat ggg gcc acc gtg ggc gtc ggt gac gtt aag tta tct gca cga 2611 Ser Asn Gly Ala Thr Val Gly Val Gly Asp Val Lys Leu Ser Ala Arg 825 830 835 gca agt gat cca agt ggc gat act gtc aag atg acg ttc ctg gaa gcc 2659 Ala Ser Asp Pro Ser Gly Asp Thr Val Lys Met Thr Phe Leu Glu Ala 840 845 850 gat tca cca aaa tta gat agt ggt cgc gtc cga atg tca tca gga acg 2707 Asp Ser Pro Lys Leu Asp Ser Gly Arg Val Arg Met Ser Ser Gly Thr 855 860 865 gta gaa gat gcc gga agt gtc tcg cgc gcc gag gcg aaa atg ttg gag 2755 Val Glu Asp Ala Gly Ser Val Ser Arg Ala Glu Ala Lys Met Leu Glu 870 875 880 885 agg gga gac gtc gag aag cta tcc agc ctg gat ggg ctg ggc atg gaa 2803 Arg Gly Asp Val Glu Lys Leu Ser Ser Leu Asp Gly Leu Gly Met Glu 890 895 900 gtt acc tcc gac gcc gca ctg ccg tac cag ctt ttt gaa gtc gat gcg 2851 Val Thr Ser Asp Ala Ala Leu Pro Tyr Gln Leu Phe Glu Val Asp Ala 905 910 915 gcg gat gca ctc gcg gcc gac act gaa gtg cgc ctg aat tgg gcg gga 2899 Ala Asp Ala Leu Ala Ala Asp Thr Glu Val Arg Leu Asn Trp Ala Gly 920 925 930 tcc gcc gat ggt cgc gcg cag gtg atc atg tat gtt ttc gat ggc gag 2947 Ser Ala Asp Gly Arg Ala Gln Val Ile Met Tyr Val Phe Asp Gly Glu 935 940 945 gcg tgg gtt gag gtg gat cgt cac ttg acc ggc gat gag ctg gaa gag 2995 Ala Trp Val Glu Val Asp Arg His Leu Thr Gly Asp Glu Leu Glu Glu 950 955 960 965 ttt acg ctg cag ggc gtc gtc aat gcg gaa aaa ttt gca atc ggc ggc 3043 Phe Thr Leu Gln Gly Val Val Asn Ala Glu Lys Phe Ala Ile Gly Gly 970 975 980 act gtc acc gta ttg att cag cac tcc gaa ggc ttc gcc ggt gcg gat 3091 Thr Val Thr Val Leu Ile Gln His Ser Glu Gly Phe Ala Gly Ala Asp 985 990 995 cat tca act aga aat tcc gac gtg acc gca gcg cac ccg gat gat gtg 3139 His Ser Thr Arg Asn Ser Asp Val Thr Ala Ala His Pro Asp Asp Val 1000 1005 1010 gct cgc tct gag tac gat ttc acc ctc gcg tgg gaa tct gac acc cag 3187 Ala Arg Ser Glu Tyr Asp Phe Thr Leu Ala Trp Glu Ser Asp Thr Gln 1015 1020 1025 tac tac aac gag gaa ttc cac gag cac caa acc aac atc cat gac tac 3235 Tyr Tyr Asn Glu Glu Phe His Glu His Gln Thr Asn Ile His Asp Tyr 1030 1035 1040 1045 gtg ctc gcc gaa cgg gag aac aag aat att cag ttc atg ttc cac act 3283 Val Leu Ala Glu Arg Glu Asn Lys Asn Ile Gln Phe Met Phe His Thr 1050 1055 1060 ggc gat gtt gtc gac gac tgg gat cag ccc gcg cag tgg gcc aca gcc 3331 Gly Asp Val Val Asp Asp Trp Asp Gln Pro Ala Gln Trp Ala Thr Ala 1065 1070 1075 aac ccc gaa tac cag cgc ctc gac gac gcc ggc ctg cca tat tct gtc 3379 Asn Pro Glu Tyr Gln Arg Leu Asp Asp Ala Gly Leu Pro Tyr Ser Val 1080 1085 1090 ctt gcc gga aac cac gat gtt ggc cac acc agc aat gac tac acc gaa 3427 Leu Ala Gly Asn His Asp Val Gly His Thr Ser Asn Asp Tyr Thr Glu 1095 1100 1105 ttc agc cga cac ttc ggc gaa cag cgc tac gta gac aac ccg tgg tac 3475 Phe Ser Arg His Phe Gly Glu Gln Arg Tyr Val Asp Asn Pro Trp Tyr 1110 1115 1120 1125 ggc gaa tcc tac caa gac aac cga ggg cac tac gat cta ttt tct gcc 3523 Gly Glu Ser Tyr Gln Asp Asn Arg Gly His Tyr Asp Leu Phe Ser Ala 1130 1135 1140 ggc gga att gac ttc att aac gta gcg atg ggc tgg ggt cca gac gac 3571 Gly Gly Ile Asp Phe Ile Asn Val Ala Met Gly Trp Gly Pro Asp Asp 1145 1150 1155 gaa gaa atc gcg tgg atg aac gag gtc ctg gcc aag cat ccc gag cgt 3619 Glu Glu Ile Ala Trp Met Asn Glu Val Leu Ala Lys His Pro Glu Arg 1160 1165 1170 gtg gcg atc ctc aac ctc cac gaa ttc atg ctc acc acc ggc gga ctt 3667 Val Ala Ile Leu Asn Leu His Glu Phe Met Leu Thr Thr Gly Gly Leu 1175 1180 1185 ggc ccg atc ccg cag cgc att ctc gac gag gtc gca gcc acc aac cca 3715 Gly Pro Ile Pro Gln Arg Ile Leu Asp Glu Val Ala Ala Thr Asn Pro 1190 1195 1200 1205 aat gtc agc atg atc atg tcc ggc cac tac cac gac gca ttc caa cgc 3763 Asn Val Ser Met Ile Met Ser Gly His Tyr His Asp Ala Phe Gln Arg 1210 1215 1220 acc gac tcc ttt gac gac gat ggt gat gga gta gat gac cgc acc gtc 3811 Thr Asp Ser Phe Asp Asp Asp Gly Asp Gly Val Asp Asp Arg Thr Val 1225 1230 1235 acc tct atg ctt ttc gat tac caa ggc cta ccg gag ggc gga cag ggg 3859 Thr Ser Met Leu Phe Asp Tyr Gln Gly Leu Pro Glu Gly Gly Gln Gly 1240 1245 1250 tac ctc cga ctt ctc cac ttt gat aac caa ggc caa aag atg atg gtg 3907 Tyr Leu Arg Leu Leu His Phe Asp Asn Gln Gly Gln Lys Met Met Val 1255 1260 1265 cgc acc tat tca cca tcc ctg aag gat tac aac tct gat gaa ccc tca 3955 Arg Thr Tyr Ser Pro Ser Leu Lys Asp Tyr Asn Ser Asp Glu Pro Ser 1270 1275 1280 1285 ctg ttg ggg cct gca gaa gac ccc aac atg tat caa gaa ttc gaa gtg 4003 Leu Leu Gly Pro Ala Glu Asp Pro Asn Met Tyr Gln Glu Phe Glu Val 1290 1295 1300 tcc tac gag cag ctc ggc atc aaa cca gag ggc cgc acc ctg atc ggc 4051 Ser Tyr Glu Gln Leu Gly Ile Lys Pro Glu Gly Arg Thr Leu Ile Gly 1305 1310 1315 gat tcc ttc agc gcc gat ttc ttg acc tcc aat gaa att gga ata gtt 4099 Asp Ser Phe Ser Ala Asp Phe Leu Thr Ser Asn Glu Ile Gly Ile Val 1320 1325 1330 gat gag gtt cct tct gga acg atc gct ttc acg aac tgg aag gac gta 4147 Asp Glu Val Pro Ser Gly Thr Ile Ala Phe Thr Asn Trp Lys Asp Val 1335 1340 1345 acc gaa ggt cgc cac agt tgg tat gtt cgc tcc gag gat cct ttc ggc 4195 Thr Glu Gly Arg His Ser Trp Tyr Val Arg Ser Glu Asp Pro Phe Gly 1350 1355 1360 1365 ggc gtc gag att tca ccc gtg cag tcc ttc att gcc ggg gaa gag gct 4243 Gly Val Glu Ile Ser Pro Val Gln Ser Phe Ile Ala Gly Glu Glu Ala 1370 1375 1380 ggc ggg aac gcg ccc ggc act gga agc tcc aat ggc ggt tca tcc cac 4291 Gly Gly Asn Ala Pro Gly Thr Gly Ser Ser Asn Gly Gly Ser Ser His 1385 1390 1395 gga tta tgg ggt gcg ctt gcg gga ttc ttt gcc gga gcg gca gcc ctg 4339 Gly Leu Trp Gly Ala Leu Ala Gly Phe Phe Ala Gly Ala Ala Ala Leu 1400 1405 1410 gct gga gct gcg atc gca ttt gtc ccc gga att tgg gac tat gtg acc 4387 Ala Gly Ala Ala Ile Ala Phe Val Pro Gly Ile Trp Asp Tyr Val Thr 1415 1420 1425 aac gca ttc aag cga taattatgga taggtaaacg ctctacacgg 4432 Asn Ala Phe Lys Arg 1430 <210> 220 <211> 1434 <212> PRT <213> Corynebacterium glutamicum <400> 220 Met Ala Val Gly Gln Glu Thr Asp Leu Leu Asn Ala Met Glu Thr Leu 1 5 10 15 Ala Gly Val Pro Ser Asp Leu Val Val Thr Glu Ile Leu Pro Asp Thr 20 25 30 Thr Ser Tyr Asp Asn Phe Glu Phe Phe Glu Val His Asn Thr Gly Ser 35 40 45 Ala Pro Val Thr Ile Gly Glu Gly Glu Tyr Thr Phe Ala Tyr Ser Phe 50 55 60 Asp Asp Ser Ala Asp Thr Ser Arg Asp Lys Ala Leu Asp Leu Gly Gly 65 70 75 80 Glu Val Thr Val Asp Ala Gly Glu Thr Ile Val Val Trp Ile Glu Tyr 85 90 95 Ser Ser Ser Thr Val Asp Thr Ala Ala Phe Ser Glu Gln Asp Phe Arg 100 105 110 Asp Phe Tyr Gly Met Asp Ser Ser Ala Arg Ile Phe Arg Ala Thr Gly 115 120 125 Gln Ala Gly Leu Ala Asn Gly Gly Asp Arg Gly Ile Arg Val Leu Tyr 130 135 140 Asn Gly Glu Val Ser Gly Trp Ser His Tyr Pro Ser Asp Ser Ala Ala 145 150 155 160 Val Gln Lys Gly Ile Asp Phe Ala Leu Pro Lys Val Gly Glu Gln Ala 165 170 175 Ser Ile Ala Val Arg Thr Lys Thr Asp Pro Thr Pro Gly Ser Ile Thr 180 185 190 Ser Asp Gln Leu Ile Pro Gly Gly Leu Asp Thr Pro Glu Glu Pro Glu 195 200 205 Ala Pro Glu Asp Ser Leu Phe Glu Gly Arg Thr Pro Pro Arg Asp Ala 210 215 220 Ala Pro Leu Ile Leu Thr Glu Leu Met Val Asn Ser Thr Asn Met Gly 225 230 235 240 Ser Ser Asp Gly Phe Glu Tyr Val Glu Ile Thr Asn Thr Thr Ala Glu 245 250 255 Pro Ile Asp Phe Ser Asp Tyr Thr Leu Asn Tyr Leu Tyr Pro Gln Asp 260 265 270 Glu Phe Thr Asn Thr Asn Glu Ala Val Trp Ala Ala Glu Pro Gly Asp 275 280 285 Val Ile Ile Gln Pro Gly Lys Ser Leu Val Phe Trp Ile Lys Asn Gly 290 295 300 Pro Asn Asp Glu Ala Thr Ala Ala Asp Phe Asn Ala Glu Tyr Gly Thr 305 310 315 320 Asn Leu Glu Ala Gly Lys Asp Leu Val Glu Ile Ser Ser Gly Gly Met 325 330 335 Ala Asn Gly Thr Ala Arg Gly Met Gln Ile Gln Thr Asn Thr Gly His 340 345 350 Ile Val Asn Arg Gly Phe Tyr Asn Met Ala Gly Ala Ser Asp Val Lys 355 360 365 Ala Asn Glu Gly Leu His Phe Ala Val Asp Glu Ser Asp Leu Leu Lys 370 375 380 Gln Thr Leu Val Gly Ser Gly Ala Pro Thr Pro Gly Thr Val Tyr Thr 385 390 395 400 Ser Gln Ile Pro Asn Pro Leu Ser Ala Val Ile Ala Asp Ser Ser Val 405 410 415 Pro Leu Ile Thr Asp Asn Thr Ala Thr Ser Ile Asn Pro Ala Glu Pro 420 425 430 Phe Thr Phe Ala Phe Asn Ile Thr Asp Asp Val Gln Val Arg Thr Ala 435 440 445 Thr Leu His Val Thr Ser Ser Ala Gly Glu Ala Ala Thr Thr Ile Asn 450 455 460 Leu Thr Glu Asp Asp Gly Ser Phe Asn Trp Ala Leu Pro Ala Ala Asp 465 470 475 480 Leu Thr Gly Lys Ser Trp Phe Glu Tyr Thr Val Thr Ala Thr Asp Gly 485 490 495 Phe Asn Ser Val Thr Thr Glu Pro Val Arg Val Thr Val Asp Gly Ala 500 505 510 Asn Thr Asp Pro Leu Arg Leu Asn Leu Glu Glu Asn Gln Trp Val Ser 515 520 525 Gly Thr Thr Asp Val Ile Gly Ala Ser Asp Val Phe Gly Asp Lys Leu 530 535 540 Glu Leu Leu Ile Asp Asp Ala Pro Ala Val Thr Asn Ser Ser Leu Ser 545 550 555 560 Ala Ala Pro Thr Phe Ala Met Glu Val Thr Gln Thr Asp Val Phe Phe 565 570 575 Arg Asn Gly Ile Leu Ala Gly Gly Glu Glu Leu Arg Ile Phe Asp Gln 580 585 590 Gly Thr Tyr Ala Asn Thr Glu Thr Ile Ser Thr Pro Val Pro Leu Tyr 595 600 605 His Ile Asn Glu Asp Gly Thr Leu Thr Val Ser Val Tyr Ala Gly Thr 610 615 620 Lys Ala Ala Pro Glu Ile Asp Leu Asn Glu Asn Asn Asp Asp Phe Gln 625 630 635 640 Ile Arg Asn Leu Arg Leu Ile Leu Pro Asp Gly Arg Thr Leu Thr Pro 645 650 655 Ala Gly Ile Ser Asp Ser Asn Ala Trp Leu Asn Met Gly Asp Ser Ala 660 665 670 Gly Lys Leu Asp Phe Phe Asp Ala Thr Phe Ala Leu Pro Glu Asp Ala 675 680 685 Phe Thr Gly Val Ala His Ala Trp Asp Thr Thr Gln Ser Thr Asp Gly 690 695 700 Glu His His Ile Thr Ile Ser Arg Glu Asp Gly Gly Glu Ile Ser Arg 705 710 715 720 Thr Ile Arg Val Asp Asn Thr Ala Pro Glu Leu Thr Val Ser Gly Val 725 730 735 Glu Glu Gly Gln Glu Leu Arg Gly Thr Val Glu Ile Asp Ala Gln Ala 740 745 750 Thr Asp Ala Gly Ala Gly Val Lys Ser Val Glu Thr Leu Leu Asp Gly 755 760 765 Glu Arg Val Gln Leu Pro Leu Thr Thr Gly Ser Ile Ala Leu Asp Lys 770 775 780 Gly Glu His Thr Leu Val Ile Arg Ala Glu Asp Glu Val Gly Asn Arg 785 790 795 800 Thr Glu Lys Thr Ile Thr Phe Ser Thr Pro Asp Glu Asn Pro Ile Ser 805 810 815 Gly Asp Tyr Ala Pro Ser Asn Gly Ala Thr Val Gly Val Gly Asp Val 820 825 830 Lys Leu Ser Ala Arg Ala Ser Asp Pro Ser Gly Asp Thr Val Lys Met 835 840 845 Thr Phe Leu Glu Ala Asp Ser Pro Lys Leu Asp Ser Gly Arg Val Arg 850 855 860 Met Ser Ser Gly Thr Val Glu Asp Ala Gly Ser Val Ser Arg Ala Glu 865 870 875 880 Ala Lys Met Leu Glu Arg Gly Asp Val Glu Lys Leu Ser Ser Leu Asp 885 890 895 Gly Leu Gly Met Glu Val Thr Ser Asp Ala Ala Leu Pro Tyr Gln Leu 900 905 910 Phe Glu Val Asp Ala Ala Asp Ala Leu Ala Ala Asp Thr Glu Val Arg 915 920 925 Leu Asn Trp Ala Gly Ser Ala Asp Gly Arg Ala Gln Val Ile Met Tyr 930 935 940 Val Phe Asp Gly Glu Ala Trp Val Glu Val Asp Arg His Leu Thr Gly 945 950 955 960 Asp Glu Leu Glu Glu Phe Thr Leu Gln Gly Val Val Asn Ala Glu Lys 965 970 975 Phe Ala Ile Gly Gly Thr Val Thr Val Leu Ile Gln His Ser Glu Gly 980 985 990 Phe Ala Gly Ala Asp His Ser Thr Arg Asn Ser Asp Val Thr Ala Ala 995 1000 1005 His Pro Asp Asp Val Ala Arg Ser Glu Tyr Asp Phe Thr Leu Ala Trp 1010 1015 1020 Glu Ser Asp Thr Gln Tyr Tyr Asn Glu Glu Phe His Glu His Gln Thr 1025 1030 1035 1040 Asn Ile His Asp Tyr Val Leu Ala Glu Arg Glu Asn Lys Asn Ile Gln 1045 1050 1055 Phe Met Phe His Thr Gly Asp Val Val Asp Asp Trp Asp Gln Pro Ala 1060 1065 1070 Gln Trp Ala Thr Ala Asn Pro Glu Tyr Gln Arg Leu Asp Asp Ala Gly 1075 1080 1085 Leu Pro Tyr Ser Val Leu Ala Gly Asn His Asp Val Gly His Thr Ser 1090 1095 1100 Asn Asp Tyr Thr Glu Phe Ser Arg His Phe Gly Glu Gln Arg Tyr Val 1105 1110 1115 1120 Asp Asn Pro Trp Tyr Gly Glu Ser Tyr Gln Asp Asn Arg Gly His Tyr 1125 1130 1135 Asp Leu Phe Ser Ala Gly Gly Ile Asp Phe Ile Asn Val Ala Met Gly 1140 1145 1150 Trp Gly Pro Asp Asp Glu Glu Ile Ala Trp Met Asn Glu Val Leu Ala 1155 1160 1165 Lys His Pro Glu Arg Val Ala Ile Leu Asn Leu His Glu Phe Met Leu 1170 1175 1180 Thr Thr Gly Gly Leu Gly Pro Ile Pro Gln Arg Ile Leu Asp Glu Val 1185 1190 1195 1200 Ala Ala Thr Asn Pro Asn Val Ser Met Ile Met Ser Gly His Tyr His 1205 1210 1215 Asp Ala Phe Gln Arg Thr Asp Ser Phe Asp Asp Asp Gly Asp Gly Val 1220 1225 1230 Asp Asp Arg Thr Val Thr Ser Met Leu Phe Asp Tyr Gln Gly Leu Pro 1235 1240 1245 Glu Gly Gly Gln Gly Tyr Leu Arg Leu Leu His Phe Asp Asn Gln Gly 1250 1255 1260 Gln Lys Met Met Val Arg Thr Tyr Ser Pro Ser Leu Lys Asp Tyr Asn 1265 1270 1275 1280 Ser Asp Glu Pro Ser Leu Leu Gly Pro Ala Glu Asp Pro Asn Met Tyr 1285 1290 1295 Gln Glu Phe Glu Val Ser Tyr Glu Gln Leu Gly Ile Lys Pro Glu Gly 1300 1305 1310 Arg Thr Leu Ile Gly Asp Ser Phe Ser Ala Asp Phe Leu Thr Ser Asn 1315 1320 1325 Glu Ile Gly Ile Val Asp Glu Val Pro Ser Gly Thr Ile Ala Phe Thr 1330 1335 1340 Asn Trp Lys Asp Val Thr Glu Gly Arg His Ser Trp Tyr Val Arg Ser 1345 1350 1355 1360 Glu Asp Pro Phe Gly Gly Val Glu Ile Ser Pro Val Gln Ser Phe Ile 1365 1370 1375 Ala Gly Glu Glu Ala Gly Gly Asn Ala Pro Gly Thr Gly Ser Ser Asn 1380 1385 1390 Gly Gly Ser Ser His Gly Leu Trp Gly Ala Leu Ala Gly Phe Phe Ala 1395 1400 1405 Gly Ala Ala Ala Leu Ala Gly Ala Ala Ile Ala Phe Val Pro Gly Ile 1410 1415 1420 Trp Asp Tyr Val Thr Asn Ala Phe Lys Arg 1425 1430 <210> 221 <211> 787 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(757) <223> RXA01966 <400> 221 gctgtccaag gccatgaatt ttgtgtcctc tgttgctcca accgctgtgc tctcccctgt 60 tatgggctgg gtttataaga agatgggtta gtttttaaaa gtg tct gaa tct gaa 115 Val Ser Glu Ser Glu 1 5 aac aac aca aca cca gca gtc gca gct cgc gat gac cgt ctg gtc tgg 163 Asn Asn Thr Thr Pro Ala Val Ala Ala Arg Asp Asp Arg Leu Val Trp 10 15 20 gtc gat ctg gaa atg act ggt cta gat ttg aag cgc cac gtg atc gtg 211 Val Asp Leu Glu Met Thr Gly Leu Asp Leu Lys Arg His Val Ile Val 25 30 35 gag gtt gcg gcg ttg gtc act gac gct aac ctc aac gtt ttg ggc gag 259 Glu Val Ala Ala Leu Val Thr Asp Ala Asn Leu Asn Val Leu Gly Glu 40 45 50 ggc gtg gac ttg gtt gtt cac gca act gaa gaa gag ctc gcg cag atg 307 Gly Val Asp Leu Val Val His Ala Thr Glu Glu Glu Leu Ala Gln Met 55 60 65 gat gat ttt gtc acc aac atg cac gaa tcc tct ggg ctg act gag cag 355 Asp Asp Phe Val Thr Asn Met His Glu Ser Ser Gly Leu Thr Glu Gln 70 75 80 85 atc cgg gaa tcc gcg gtc acg ttg aag gaa gcc gaa gat gct gtg ctc 403 Ile Arg Glu Ser Ala Val Thr Leu Lys Glu Ala Glu Asp Ala Val Leu 90 95 100 gca ttg att gaa aag cac tgc gat cca gcc cat cct gca ccg cta gct 451 Ala Leu Ile Glu Lys His Cys Asp Pro Ala His Pro Ala Pro Leu Ala 105 110 115 ggt aac tcc att gcc act gac cgc gcg ttt atc cgc gaa cat atg cca 499 Gly Asn Ser Ile Ala Thr Asp Arg Ala Phe Ile Arg Glu His Met Pro 120 125 130 cgt ctt gat gag gcc ctg cat tac cgc atg gtg gat gtg tcc tcg gtg 547 Arg Leu Asp Glu Ala Leu His Tyr Arg Met Val Asp Val Ser Ser Val 135 140 145 aag gaa ttg gcg cgt cgc tgg tac cca cgc gtg tac tac aag cag ccg 595 Lys Glu Leu Ala Arg Arg Trp Tyr Pro Arg Val Tyr Tyr Lys Gln Pro 150 155 160 165 gag aag ggt ttg gcg cac cgc gcg ttg gcg gac att gtg gag tcg att 643 Glu Lys Gly Leu Ala His Arg Ala Leu Ala Asp Ile Val Glu Ser Ile 170 175 180 cgg gag ttg gat tac tac cgt cgc tca ttt ttt gtt gca gag cct ggt 691 Arg Glu Leu Asp Tyr Tyr Arg Arg Ser Phe Phe Val Ala Glu Pro Gly 185 190 195 cct acc tct gag cag tgc gca gat gat gcg cag gca gcg gtg gac cgt 739 Pro Thr Ser Glu Gln Cys Ala Asp Asp Ala Gln Ala Ala Val Asp Arg 200 205 210 ttt gca ccc tac ttt gat tagagggttt taagcagcct ggtgagttcg 787 Phe Ala Pro Tyr Phe Asp 215 <210> 222 <211> 219 <212> PRT <213> Corynebacterium glutamicum <400> 222 Val Ser Glu Ser Glu Asn Asn Thr Thr Pro Ala Val Ala Ala Arg Asp 1 5 10 15 Asp Arg Leu Val Trp Val Asp Leu Glu Met Thr Gly Leu Asp Leu Lys 20 25 30 Arg His Val Ile Val Glu Val Ala Ala Leu Val Thr Asp Ala Asn Leu 35 40 45 Asn Val Leu Gly Glu Gly Val Asp Leu Val Val His Ala Thr Glu Glu 50 55 60 Glu Leu Ala Gln Met Asp Asp Phe Val Thr Asn Met His Glu Ser Ser 65 70 75 80 Gly Leu Thr Glu Gln Ile Arg Glu Ser Ala Val Thr Leu Lys Glu Ala 85 90 95 Glu Asp Ala Val Leu Ala Leu Ile Glu Lys His Cys Asp Pro Ala His 100 105 110 Pro Ala Pro Leu Ala Gly Asn Ser Ile Ala Thr Asp Arg Ala Phe Ile 115 120 125 Arg Glu His Met Pro Arg Leu Asp Glu Ala Leu His Tyr Arg Met Val 130 135 140 Asp Val Ser Ser Val Lys Glu Leu Ala Arg Arg Trp Tyr Pro Arg Val 145 150 155 160 Tyr Tyr Lys Gln Pro Glu Lys Gly Leu Ala His Arg Ala Leu Ala Asp 165 170 175 Ile Val Glu Ser Ile Arg Glu Leu Asp Tyr Tyr Arg Arg Ser Phe Phe 180 185 190 Val Ala Glu Pro Gly Pro Thr Ser Glu Gln Cys Ala Asp Asp Ala Gln 195 200 205 Ala Ala Val Asp Arg Phe Ala Pro Tyr Phe Asp 210 215 <210> 223 <211> 1288 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1258) <223> RXA01982 <400> 223 tgccgccgac catgagatga tcaagcgctt tttcaccctg caccttcgct aagactctac 60 cttcacccaa ctcatcatct actgaaagaa ggcttctgct atg gct acc acc agc 115 Met Ala Thr Thr Ser 1 5 ctc ccc acg acg att aca ccg gat tcc gag gag acc gta gaa aag cgt 163 Leu Pro Thr Thr Ile Thr Pro Asp Ser Glu Glu Thr Val Glu Lys Arg 10 15 20 cac tcc ctg acc ccg atc ctg gat tca ctt ccc tgc gag tca gtt ccc 211 His Ser Leu Thr Pro Ile Leu Asp Ser Leu Pro Cys Glu Ser Val Pro 25 30 35 tat gct ctg gct gca ggt gag gga caa caa cac cag ctt ggc ccc tac 259 Tyr Ala Leu Ala Ala Gly Glu Gly Gln Gln His Gln Leu Gly Pro Tyr 40 45 50 cat ctc aca gtt atg tcc cgt ccc gaa gac aac ggt gga ata ttt tcg 307 His Leu Thr Val Met Ser Arg Pro Glu Asp Asn Gly Gly Ile Phe Ser 55 60 65 ctg gct cgt gtg agc gca ggc aag act ccc gcc acc cgg ttc ttc tct 355 Leu Ala Arg Val Ser Ala Gly Lys Thr Pro Ala Thr Arg Phe Phe Ser 70 75 80 85 gtc gca gga ccg acg ttc ctc tac atg atg gag ggg cgg ttg act ctc 403 Val Ala Gly Pro Thr Phe Leu Tyr Met Met Glu Gly Arg Leu Thr Leu 90 95 100 tgg ttc gct gat gga cgt caa gag atc atc gct ggc ggc agt gcc acc 451 Trp Phe Ala Asp Gly Arg Gln Glu Ile Ile Ala Gly Gly Ser Ala Thr 105 110 115 att cct acg aat acg ccc tgg tcc ttc gcc tgt gag ggc cta gta aat 499 Ile Pro Thr Asn Thr Pro Trp Ser Phe Ala Cys Glu Gly Leu Val Asn 120 125 130 tca gct cta gtg tac tac tca tcc tcg aat gca ttc cta cac gcg gca 547 Ser Ala Leu Val Tyr Tyr Ser Ser Ser Asn Ala Phe Leu His Ala Ala 135 140 145 gag aaa ctt ggc acg tcc tcg ttc tcc cac acc ttc cgc gtc agt ggc 595 Glu Lys Leu Gly Thr Ser Ser Phe Ser His Thr Phe Arg Val Ser Gly 150 155 160 165 gag gtc aca ggg att ccc tac gag gaa ctg gag gat tgc gga ttc aca 643 Glu Val Thr Gly Ile Pro Tyr Glu Glu Leu Glu Asp Cys Gly Phe Thr 170 175 180 ttc tat gag cgg gac cac ctt gcc gag ctc ggg ccg cat ttc gat cgc 691 Phe Tyr Glu Arg Asp His Leu Ala Glu Leu Gly Pro His Phe Asp Arg 185 190 195 ctc cca gaa gat atg aag gcg ttt gcc ctg aac gat ggt gag ggg gac 739 Leu Pro Glu Asp Met Lys Ala Phe Ala Leu Asn Asp Gly Glu Gly Asp 200 205 210 cgg ctt gag cag ttc gag cag atc aac agc ttc gtc tgc cgt ccg aga 787 Arg Leu Glu Gln Phe Glu Gln Ile Asn Ser Phe Val Cys Arg Pro Arg 215 220 225 cac acc gga aat cag ttc ctc gct atg cag acc aag ggt gcc aag acg 835 His Thr Gly Asn Gln Phe Leu Ala Met Gln Thr Lys Gly Ala Lys Thr 230 235 240 245 cct tat ata cct cgt cat ttc cac cgc ctt cac acc gaa aac ttc atc 883 Pro Tyr Ile Pro Arg His Phe His Arg Leu His Thr Glu Asn Phe Ile 250 255 260 tgt ctg gac ggg cgc gtc aaa ctg cac gtc aac ggt caa gag atc atc 931 Cys Leu Asp Gly Arg Val Lys Leu His Val Asn Gly Gln Glu Ile Ile 265 270 275 ctc tcc cgt ggg gat tac gtt cat gcc cca gcc gga acc atc cac tct 979 Leu Ser Arg Gly Asp Tyr Val His Ala Pro Ala Gly Thr Ile His Ser 280 285 290 ttc gcc ttc gca ggg cac aat acc cag atg ctg gga gtg ctc acc aca 1027 Phe Ala Phe Ala Gly His Asn Thr Gln Met Leu Gly Val Leu Thr Thr 295 300 305 gag gta ttc gag aag ttc ttt gac tac ata aac act ccg act aat gct 1075 Glu Val Phe Glu Lys Phe Phe Asp Tyr Ile Asn Thr Pro Thr Asn Ala 310 315 320 325 cga gtt cag ctg gag gac ggg ggg aag cca ttt ttt cct gct gaa gca 1123 Arg Val Gln Leu Glu Asp Gly Gly Lys Pro Phe Phe Pro Ala Glu Ala 330 335 340 ttc gcg aaa gtc caa gct gaa ctc gat gtc gtg gtg gtc ggc ccc cca 1171 Phe Ala Lys Val Gln Ala Glu Leu Asp Val Val Val Val Gly Pro Pro 345 350 355 cga att agt acc ctg gat gtt gtt aca aac tcg cgt ttc gaa cca att 1219 Arg Ile Ser Thr Leu Asp Val Val Thr Asn Ser Arg Phe Glu Pro Ile 360 365 370 aac aga act atc acc tat cgt gcg ctg gac gct aac caa tagtgagtga 1268 Asn Arg Thr Ile Thr Tyr Arg Ala Leu Asp Ala Asn Gln 375 380 385 gccgaaatcc ctgtttgtaa 1288 <210> 224 <211> 386 <212> PRT <213> Corynebacterium glutamicum <400> 224 Met Ala Thr Thr Ser Leu Pro Thr Thr Ile Thr Pro Asp Ser Glu Glu 1 5 10 15 Thr Val Glu Lys Arg His Ser Leu Thr Pro Ile Leu Asp Ser Leu Pro 20 25 30 Cys Glu Ser Val Pro Tyr Ala Leu Ala Ala Gly Glu Gly Gln Gln His 35 40 45 Gln Leu Gly Pro Tyr His Leu Thr Val Met Ser Arg Pro Glu Asp Asn 50 55 60 Gly Gly Ile Phe Ser Leu Ala Arg Val Ser Ala Gly Lys Thr Pro Ala 65 70 75 80 Thr Arg Phe Phe Ser Val Ala Gly Pro Thr Phe Leu Tyr Met Met Glu 85 90 95 Gly Arg Leu Thr Leu Trp Phe Ala Asp Gly Arg Gln Glu Ile Ile Ala 100 105 110 Gly Gly Ser Ala Thr Ile Pro Thr Asn Thr Pro Trp Ser Phe Ala Cys 115 120 125 Glu Gly Leu Val Asn Ser Ala Leu Val Tyr Tyr Ser Ser Ser Asn Ala 130 135 140 Phe Leu His Ala Ala Glu Lys Leu Gly Thr Ser Ser Phe Ser His Thr 145 150 155 160 Phe Arg Val Ser Gly Glu Val Thr Gly Ile Pro Tyr Glu Glu Leu Glu 165 170 175 Asp Cys Gly Phe Thr Phe Tyr Glu Arg Asp His Leu Ala Glu Leu Gly 180 185 190 Pro His Phe Asp Arg Leu Pro Glu Asp Met Lys Ala Phe Ala Leu Asn 195 200 205 Asp Gly Glu Gly Asp Arg Leu Glu Gln Phe Glu Gln Ile Asn Ser Phe 210 215 220 Val Cys Arg Pro Arg His Thr Gly Asn Gln Phe Leu Ala Met Gln Thr 225 230 235 240 Lys Gly Ala Lys Thr Pro Tyr Ile Pro Arg His Phe His Arg Leu His 245 250 255 Thr Glu Asn Phe Ile Cys Leu Asp Gly Arg Val Lys Leu His Val Asn 260 265 270 Gly Gln Glu Ile Ile Leu Ser Arg Gly Asp Tyr Val His Ala Pro Ala 275 280 285 Gly Thr Ile His Ser Phe Ala Phe Ala Gly His Asn Thr Gln Met Leu 290 295 300 Gly Val Leu Thr Thr Glu Val Phe Glu Lys Phe Phe Asp Tyr Ile Asn 305 310 315 320 Thr Pro Thr Asn Ala Arg Val Gln Leu Glu Asp Gly Gly Lys Pro Phe 325 330 335 Phe Pro Ala Glu Ala Phe Ala Lys Val Gln Ala Glu Leu Asp Val Val 340 345 350 Val Val Gly Pro Pro Arg Ile Ser Thr Leu Asp Val Val Thr Asn Ser 355 360 365 Arg Phe Glu Pro Ile Asn Arg Thr Ile Thr Tyr Arg Ala Leu Asp Ala 370 375 380 Asn Gln 385 <210> 225 <211> 1078 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1048) <223> RXA02021 <400> 225 ttgggtcgcc gaggagatct aatcctggtt tgagttcaga gttcacaggt ttaagcctac 60 aaaccttagt taaaacatga tggaagcggt cgattaaaaa atg agt gaa aac att 115 Met Ser Glu Asn Ile 1 5 cgc gga gcc caa gca gtt gga atc gca aat atc gcc atg gac ggg acc 163 Arg Gly Ala Gln Ala Val Gly Ile Ala Asn Ile Ala Met Asp Gly Thr 10 15 20 atc ctg gac acg tgg tac cca gaa ccc caa att ttc aac ccg gat cag 211 Ile Leu Asp Thr Trp Tyr Pro Glu Pro Gln Ile Phe Asn Pro Asp Gln 25 30 35 tgg gct gaa cgc tac cca ttg gaa gtg ggc acc aca cgc ctc gga gca 259 Trp Ala Glu Arg Tyr Pro Leu Glu Val Gly Thr Thr Arg Leu Gly Ala 40 45 50 aac gaa ctc acc cca cgg atg ctg cag ttg gta aaa ctg gac caa gat 307 Asn Glu Leu Thr Pro Arg Met Leu Gln Leu Val Lys Leu Asp Gln Asp 55 60 65 cgc ctc gtc gaa cag gta gca gtc cgc acc gtt atc ccc gat ctg tct 355 Arg Leu Val Glu Gln Val Ala Val Arg Thr Val Ile Pro Asp Leu Ser 70 75 80 85 caa cct cca gta gac gcg cac gat gtt tac ctg cgc ctc cac ctg ctt 403 Gln Pro Pro Val Asp Ala His Asp Val Tyr Leu Arg Leu His Leu Leu 90 95 100 tcc cac cgc ctg gtc cgc ccc cac gaa atg cac atg caa aac acc ttg 451 Ser His Arg Leu Val Arg Pro His Glu Met His Met Gln Asn Thr Leu 105 110 115 gag ctg ctg tcc gac gtg gtg tgg aca aac aag ggc cct tgc ctt cct 499 Glu Leu Leu Ser Asp Val Val Trp Thr Asn Lys Gly Pro Cys Leu Pro 120 125 130 gaa aac ttt gag tgg gtg cgt ggt gct ctg cgg tcc cgc gga ctc atc 547 Glu Asn Phe Glu Trp Val Arg Gly Ala Leu Arg Ser Arg Gly Leu Ile 135 140 145 cac gtc tac tgt gtg gac cgt ctt ccc cgc atg gtc gac tat gtg gtt 595 His Val Tyr Cys Val Asp Arg Leu Pro Arg Met Val Asp Tyr Val Val 150 155 160 165 ccc cct gga gtc cgc atc tcc gaa gca gaa cgc gtg cgc cta ggt gca 643 Pro Pro Gly Val Arg Ile Ser Glu Ala Glu Arg Val Arg Leu Gly Ala 170 175 180 tac ctt gct ccg ggt acc tct gtg ctg cgt gaa ggt ttc gtg tct ttc 691 Tyr Leu Ala Pro Gly Thr Ser Val Leu Arg Glu Gly Phe Val Ser Phe 185 190 195 aac tcc ggc acc ttg ggt gcc gca aag gtg gaa ggc cgc ctg agt tcc 739 Asn Ser Gly Thr Leu Gly Ala Ala Lys Val Glu Gly Arg Leu Ser Ser 200 205 210 ggt gtg gtc atc ggt gaa ggt tcc gag att gga ctg tct tct act att 787 Gly Val Val Ile Gly Glu Gly Ser Glu Ile Gly Leu Ser Ser Thr Ile 215 220 225 cag tcc ccg aga gat gaa cag cgc cgc cgt ttg ccg ttg agc atc ggc 835 Gln Ser Pro Arg Asp Glu Gln Arg Arg Arg Leu Pro Leu Ser Ile Gly 230 235 240 245 caa aac tgc aac ttt ggt gtc agc tcc gga atc atc gga gtc agt ctg 883 Gln Asn Cys Asn Phe Gly Val Ser Ser Gly Ile Ile Gly Val Ser Leu 250 255 260 gga gac aat tgc gac atc gga aat aac att gtc ttg gat gga gat acc 931 Gly Asp Asn Cys Asp Ile Gly Asn Asn Ile Val Leu Asp Gly Asp Thr 265 270 275 ccc att tgg ttc gca gcc gat gag gag tta cgc act atc gac tcc atc 979 Pro Ile Trp Phe Ala Ala Asp Glu Glu Leu Arg Thr Ile Asp Ser Ile 280 285 290 gaa ggc caa gca aat tgg tca atc aag cgt gaa tcc ggc ttc cat gag 1027 Glu Gly Gln Ala Asn Trp Ser Ile Lys Arg Glu Ser Gly Phe His Glu 295 300 305 cca gtt gcc cgc ctc aaa gct tgacccattt tcataaccag tgccatgtgg 1078 Pro Val Ala Arg Leu Lys Ala 310 315 <210> 226 <211> 316 <212> PRT <213> Corynebacterium glutamicum <400> 226 Met Ser Glu Asn Ile Arg Gly Ala Gln Ala Val Gly Ile Ala Asn Ile 1 5 10 15 Ala Met Asp Gly Thr Ile Leu Asp Thr Trp Tyr Pro Glu Pro Gln Ile 20 25 30 Phe Asn Pro Asp Gln Trp Ala Glu Arg Tyr Pro Leu Glu Val Gly Thr 35 40 45 Thr Arg Leu Gly Ala Asn Glu Leu Thr Pro Arg Met Leu Gln Leu Val 50 55 60 Lys Leu Asp Gln Asp Arg Leu Val Glu Gln Val Ala Val Arg Thr Val 65 70 75 80 Ile Pro Asp Leu Ser Gln Pro Pro Val Asp Ala His Asp Val Tyr Leu 85 90 95 Arg Leu His Leu Leu Ser His Arg Leu Val Arg Pro His Glu Met His 100 105 110 Met Gln Asn Thr Leu Glu Leu Leu Ser Asp Val Val Trp Thr Asn Lys 115 120 125 Gly Pro Cys Leu Pro Glu Asn Phe Glu Trp Val Arg Gly Ala Leu Arg 130 135 140 Ser Arg Gly Leu Ile His Val Tyr Cys Val Asp Arg Leu Pro Arg Met 145 150 155 160 Val Asp Tyr Val Val Pro Pro Gly Val Arg Ile Ser Glu Ala Glu Arg 165 170 175 Val Arg Leu Gly Ala Tyr Leu Ala Pro Gly Thr Ser Val Leu Arg Glu 180 185 190 Gly Phe Val Ser Phe Asn Ser Gly Thr Leu Gly Ala Ala Lys Val Glu 195 200 205 Gly Arg Leu Ser Ser Gly Val Val Ile Gly Glu Gly Ser Glu Ile Gly 210 215 220 Leu Ser Ser Thr Ile Gln Ser Pro Arg Asp Glu Gln Arg Arg Arg Leu 225 230 235 240 Pro Leu Ser Ile Gly Gln Asn Cys Asn Phe Gly Val Ser Ser Gly Ile 245 250 255 Ile Gly Val Ser Leu Gly Asp Asn Cys Asp Ile Gly Asn Asn Ile Val 260 265 270 Leu Asp Gly Asp Thr Pro Ile Trp Phe Ala Ala Asp Glu Glu Leu Arg 275 280 285 Thr Ile Asp Ser Ile Glu Gly Gln Ala Asn Trp Ser Ile Lys Arg Glu 290 295 300 Ser Gly Phe His Glu Pro Val Ala Arg Leu Lys Ala 305 310 315 <210> 227 <211> 829 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(799) <223> RXA02032 <400> 227 tggcgcaacc acttccattt cgaaggggag tagttccaca caaaggcgat ctgactcgtt 60 tttgtttgag gtatgttcga catactggag caagttcacc ttg cac ccg gca tac 115 Leu His Pro Ala Tyr 1 5 cac ctg aac aag gcc tta aaa agg ggc ttt atc ggt tca ggc gag cga 163 His Leu Asn Lys Ala Leu Lys Arg Gly Phe Ile Gly Ser Gly Glu Arg 10 15 20 gac ctt cgg cgt tca cac ttc gcc ggg gtc tat ttt tta tgc cca ggc 211 Asp Leu Arg Arg Ser His Phe Ala Gly Val Tyr Phe Leu Cys Pro Gly 25 30 35 acg gct cat agg aga acc atg ccc ttt cta caa atc tct ctg ctt tcc 259 Thr Ala His Arg Arg Thr Met Pro Phe Leu Gln Ile Ser Leu Leu Ser 40 45 50 atc ggt gtc gcc gcc gat gcg ttt gct tgt tcc gtt gtc cgc ggc acc 307 Ile Gly Val Ala Ala Asp Ala Phe Ala Cys Ser Val Val Arg Gly Thr 55 60 65 gcc att caa gtc aac ctt ttc aaa cgc gca ctt gtt ctc gcg ggc atc 355 Ala Ile Gln Val Asn Leu Phe Lys Arg Ala Leu Val Leu Ala Gly Ile 70 75 80 85 ttt ggt gtc ttc caa gcg gca atg cct tta atc ggc tgg ttc att ggc 403 Phe Gly Val Phe Gln Ala Ala Met Pro Leu Ile Gly Trp Phe Ile Gly 90 95 100 cgt ttc ttt gct gga atc acc ttc atc gct gaa att gat cac tgg atc 451 Arg Phe Phe Ala Gly Ile Thr Phe Ile Ala Glu Ile Asp His Trp Ile 105 110 115 gct ttt gca cta ttg ggt att gtc ggc acc aaa atg atc tgg gat gcc 499 Ala Phe Ala Leu Leu Gly Ile Val Gly Thr Lys Met Ile Trp Asp Ala 120 125 130 ttc caa cct gaa gat gat gaa acc att gtc gat gac ggc cgc gtt caa 547 Phe Gln Pro Glu Asp Asp Glu Thr Ile Val Asp Asp Gly Arg Val Gln 135 140 145 ttt aga cca gca att atc ctg ggg cta gcc acc agc att gac gca tta 595 Phe Arg Pro Ala Ile Ile Leu Gly Leu Ala Thr Ser Ile Asp Ala Leu 150 155 160 165 gcc gta ggc atg ggc ctg gca ttc gtg gaa gtt tcc atc ctc aaa gtg 643 Ala Val Gly Met Gly Leu Ala Phe Val Glu Val Ser Ile Leu Lys Val 170 175 180 gca ctg tcc atg ggc agc atc acc ttc gca ctt tcg ctt gct ggc gcc 691 Ala Leu Ser Met Gly Ser Ile Thr Phe Ala Leu Ser Leu Ala Gly Ala 185 190 195 tgg atc gga cac cat ggt gga gga aag ttt ggc aag tgg gct acg att 739 Trp Ile Gly His His Gly Gly Gly Lys Phe Gly Lys Trp Ala Thr Ile 200 205 210 ctt ggc gga ata atc ttg atc gga atc ggc gca aac atc gtc tac gaa 787 Leu Gly Gly Ile Ile Leu Ile Gly Ile Gly Ala Asn Ile Val Tyr Glu 215 220 225 cac ctc agc gcg taaccctcgg cgcattatcc tcagacagct 829 His Leu Ser Ala 230 <210> 228 <211> 233 <212> PRT <213> Corynebacterium glutamicum <400> 228 Leu His Pro Ala Tyr His Leu Asn Lys Ala Leu Lys Arg Gly Phe Ile 1 5 10 15 Gly Ser Gly Glu Arg Asp Leu Arg Arg Ser His Phe Ala Gly Val Tyr 20 25 30 Phe Leu Cys Pro Gly Thr Ala His Arg Arg Thr Met Pro Phe Leu Gln 35 40 45 Ile Ser Leu Leu Ser Ile Gly Val Ala Ala Asp Ala Phe Ala Cys Ser 50 55 60 Val Val Arg Gly Thr Ala Ile Gln Val Asn Leu Phe Lys Arg Ala Leu 65 70 75 80 Val Leu Ala Gly Ile Phe Gly Val Phe Gln Ala Ala Met Pro Leu Ile 85 90 95 Gly Trp Phe Ile Gly Arg Phe Phe Ala Gly Ile Thr Phe Ile Ala Glu 100 105 110 Ile Asp His Trp Ile Ala Phe Ala Leu Leu Gly Ile Val Gly Thr Lys 115 120 125 Met Ile Trp Asp Ala Phe Gln Pro Glu Asp Asp Glu Thr Ile Val Asp 130 135 140 Asp Gly Arg Val Gln Phe Arg Pro Ala Ile Ile Leu Gly Leu Ala Thr 145 150 155 160 Ser Ile Asp Ala Leu Ala Val Gly Met Gly Leu Ala Phe Val Glu Val 165 170 175 Ser Ile Leu Lys Val Ala Leu Ser Met Gly Ser Ile Thr Phe Ala Leu 180 185 190 Ser Leu Ala Gly Ala Trp Ile Gly His His Gly Gly Gly Lys Phe Gly 195 200 205 Lys Trp Ala Thr Ile Leu Gly Gly Ile Ile Leu Ile Gly Ile Gly Ala 210 215 220 Asn Ile Val Tyr Glu His Leu Ser Ala 225 230 <210> 229 <211> 709 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(679) <223> RXA02053 <400> 229 aaccagccag aaactatctc caaaagctaa taaaaccctt gcactgacaa ataaggcgac 60 ctaccatgac tctgtttcca acacataaaa aggataaaaa atg tca ctt tca gtc 115 Met Ser Leu Ser Val 1 5 gtc gag gcg att acc aac cgc cgc gcc acc cgc aaa tac acc gat gaa 163 Val Glu Ala Ile Thr Asn Arg Arg Ala Thr Arg Lys Tyr Thr Asp Glu 10 15 20 gct cct acc cct gag ctg atc gac aaa atc gtt gac ctt gcc ctg gag 211 Ala Pro Thr Pro Glu Leu Ile Asp Lys Ile Val Asp Leu Ala Leu Glu 25 30 35 gca ccc agt gcg ttc aat gcg cag caa cgt gaa att gtt gtg att act 259 Ala Pro Ser Ala Phe Asn Ala Gln Gln Arg Glu Ile Val Val Ile Thr 40 45 50 gat ccc gca cag aag cag aag ctt tac gag gcc tcc cat cag aaa caa 307 Asp Pro Ala Gln Lys Gln Lys Leu Tyr Glu Ala Ser His Gln Lys Gln 55 60 65 ttc ctc acc gca cct gta act ttc att gcg gtt gcc cgc gtg gaa aac 355 Phe Leu Thr Ala Pro Val Thr Phe Ile Ala Val Ala Arg Val Glu Asn 70 75 80 85 gag cct gag gat ttg gaa gag att ctt ggt acg gaa agg gct gaa cgt 403 Glu Pro Glu Asp Leu Glu Glu Ile Leu Gly Thr Glu Arg Ala Glu Arg 90 95 100 gtc gcg gga ttc atc aac ggt cgc agc att cag cag gca cgc gaa gca 451 Val Ala Gly Phe Ile Asn Gly Arg Ser Ile Gln Gln Ala Arg Glu Ala 105 110 115 acg ttg agg gat gcc agc ctc gcg gcg gct ttt cta att ctg gct gcc 499 Thr Leu Arg Asp Ala Ser Leu Ala Ala Ala Phe Leu Ile Leu Ala Ala 120 125 130 cag gcg gag ggt ttg agt acc agc ccg act act ggt tgg gat gag gaa 547 Gln Ala Glu Gly Leu Ser Thr Ser Pro Thr Thr Gly Trp Asp Glu Glu 135 140 145 aaa gtg aag gaa gca atc ggt ctc ggc ggg cgt gag gat cgt gca atc 595 Lys Val Lys Glu Ala Ile Gly Leu Gly Gly Arg Glu Asp Arg Ala Ile 150 155 160 165 gcc ctt gtt att gct acc gga ttc cct aat gaa cag ccg gag cac cct 643 Ala Leu Val Ile Ala Thr Gly Phe Pro Asn Glu Gln Pro Glu His Pro 170 175 180 ggt cgt ttg cag aat agg cgc atc gac aac agc tac taactctgcc 689 Gly Arg Leu Gln Asn Arg Arg Ile Asp Asn Ser Tyr 185 190 agctcgcccg gacgaactaa 709 <210> 230 <211> 193 <212> PRT <213> Corynebacterium glutamicum <400> 230 Met Ser Leu Ser Val Val Glu Ala Ile Thr Asn Arg Arg Ala Thr Arg 1 5 10 15 Lys Tyr Thr Asp Glu Ala Pro Thr Pro Glu Leu Ile Asp Lys Ile Val 20 25 30 Asp Leu Ala Leu Glu Ala Pro Ser Ala Phe Asn Ala Gln Gln Arg Glu 35 40 45 Ile Val Val Ile Thr Asp Pro Ala Gln Lys Gln Lys Leu Tyr Glu Ala 50 55 60 Ser His Gln Lys Gln Phe Leu Thr Ala Pro Val Thr Phe Ile Ala Val 65 70 75 80 Ala Arg Val Glu Asn Glu Pro Glu Asp Leu Glu Glu Ile Leu Gly Thr 85 90 95 Glu Arg Ala Glu Arg Val Ala Gly Phe Ile Asn Gly Arg Ser Ile Gln 100 105 110 Gln Ala Arg Glu Ala Thr Leu Arg Asp Ala Ser Leu Ala Ala Ala Phe 115 120 125 Leu Ile Leu Ala Ala Gln Ala Glu Gly Leu Ser Thr Ser Pro Thr Thr 130 135 140 Gly Trp Asp Glu Glu Lys Val Lys Glu Ala Ile Gly Leu Gly Gly Arg 145 150 155 160 Glu Asp Arg Ala Ile Ala Leu Val Ile Ala Thr Gly Phe Pro Asn Glu 165 170 175 Gln Pro Glu His Pro Gly Arg Leu Gln Asn Arg Arg Ile Asp Asn Ser 180 185 190 Tyr <210> 231 <211> 796 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(766) <223> RXA02058 <400> 231 gcgctatgat gtgatttgtt ccccagaacg tgctcgggaa gctcgagaca tgattgccct 60 gaaaactcga gatctccgcc aataagttaa actaacgcct atg aaa aat gtg ggg 115 Met Lys Asn Val Gly 1 5 aag cgg att tta gtc ctt gcg ctt ggt gcc tcg gta gcg gga tgc tca 163 Lys Arg Ile Leu Val Leu Ala Leu Gly Ala Ser Val Ala Gly Cys Ser 10 15 20 acg ctt tcc caa gaa cct tca cca cct gtt ccg ttg gga aac gtt gat 211 Thr Leu Ser Gln Glu Pro Ser Pro Pro Val Pro Leu Gly Asn Val Asp 25 30 35 act gtg cag att gtc tct ccc aat ggg gag att gag tct ttt gtg ctg 259 Thr Val Gln Ile Val Ser Pro Asn Gly Glu Ile Glu Ser Phe Val Leu 40 45 50 ggg aag ctg tat gag acc gca tta gtg gaa cgt ggc aga tct gca tca 307 Gly Lys Leu Tyr Glu Thr Ala Leu Val Glu Arg Gly Arg Ser Ala Ser 55 60 65 gtt cag ctg att gac ggc gac ttg gat gag caa cta tct atg ctg cga 355 Val Gln Leu Ile Asp Gly Asp Leu Asp Glu Gln Leu Ser Met Leu Arg 70 75 80 85 gat gac agc act gat ttg gtg att gct tgc tca gga caa tta ctg gaa 403 Asp Asp Ser Thr Asp Leu Val Ile Ala Cys Ser Gly Gln Leu Leu Glu 90 95 100 tat tac aac cca gat tta gcc tcc gag ttt gcc gtc gaa tac gct aat 451 Tyr Tyr Asn Pro Asp Leu Ala Ser Glu Phe Ala Val Glu Tyr Ala Asn 105 110 115 cag aca gcc ttt gat aaa aac tct ggt gaa tgg cgc gaa aaa gtc tac 499 Gln Thr Ala Phe Asp Lys Asn Ser Gly Glu Trp Arg Glu Lys Val Tyr 120 125 130 gat gct ctc caa gga tcg ctg ccg gac tcc atc gtg gcc acc gat cct 547 Asp Ala Leu Gln Gly Ser Leu Pro Asp Ser Ile Val Ala Thr Asp Pro 135 140 145 tcc aat gct att ggt tgt aag gac gat acg tcg ctg cct caa aac atc 595 Ser Asn Ala Ile Gly Cys Lys Asp Asp Thr Ser Leu Pro Gln Asn Ile 150 155 160 165 gtg cca att tat aga aag ccc aat ctg gat agg gac aat cgg gac acc 643 Val Pro Ile Tyr Arg Lys Pro Asn Leu Asp Arg Asp Asn Arg Asp Thr 170 175 180 ctg aac ttt gtg agc ggt tct ttg ggt aca agc gat ttg gaa gca ttg 691 Leu Asn Phe Val Ser Gly Ser Leu Gly Thr Ser Asp Leu Glu Ala Leu 185 190 195 gtc aag gac gcc caa aca aca ggc aca acc tct gaa act gcg ctg gat 739 Val Lys Asp Ala Gln Thr Thr Gly Thr Thr Ser Glu Thr Ala Leu Asp 200 205 210 ttc tta ttg tct aaa gga ttt tca cgc tagttcagcc gtggtgatgc 786 Phe Leu Leu Ser Lys Gly Phe Ser Arg 215 220 acgtgggggc 796 <210> 232 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 232 Met Lys Asn Val Gly Lys Arg Ile Leu Val Leu Ala Leu Gly Ala Ser 1 5 10 15 Val Ala Gly Cys Ser Thr Leu Ser Gln Glu Pro Ser Pro Pro Val Pro 20 25 30 Leu Gly Asn Val Asp Thr Val Gln Ile Val Ser Pro Asn Gly Glu Ile 35 40 45 Glu Ser Phe Val Leu Gly Lys Leu Tyr Glu Thr Ala Leu Val Glu Arg 50 55 60 Gly Arg Ser Ala Ser Val Gln Leu Ile Asp Gly Asp Leu Asp Glu Gln 65 70 75 80 Leu Ser Met Leu Arg Asp Asp Ser Thr Asp Leu Val Ile Ala Cys Ser 85 90 95 Gly Gln Leu Leu Glu Tyr Tyr Asn Pro Asp Leu Ala Ser Glu Phe Ala 100 105 110 Val Glu Tyr Ala Asn Gln Thr Ala Phe Asp Lys Asn Ser Gly Glu Trp 115 120 125 Arg Glu Lys Val Tyr Asp Ala Leu Gln Gly Ser Leu Pro Asp Ser Ile 130 135 140 Val Ala Thr Asp Pro Ser Asn Ala Ile Gly Cys Lys Asp Asp Thr Ser 145 150 155 160 Leu Pro Gln Asn Ile Val Pro Ile Tyr Arg Lys Pro Asn Leu Asp Arg 165 170 175 Asp Asn Arg Asp Thr Leu Asn Phe Val Ser Gly Ser Leu Gly Thr Ser 180 185 190 Asp Leu Glu Ala Leu Val Lys Asp Ala Gln Thr Thr Gly Thr Thr Ser 195 200 205 Glu Thr Ala Leu Asp Phe Leu Leu Ser Lys Gly Phe Ser Arg 210 215 220 <210> 233 <211> 625 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(595) <223> RXA02059 <400> 233 tcgggaaatt ccactcatga acgcctagtc tacgggaacc atttcaccag cgtgtacgtt 60 gtaaatgtga actgaaaaag tgaaaaggaa gatgataaag atg act caa cca cgg 115 Met Thr Gln Pro Arg 1 5 ccc gat gcc gca tct gtg tcg ctg gaa aag aag cgc cca gaa gga tgg 163 Pro Asp Ala Ala Ser Val Ser Leu Glu Lys Lys Arg Pro Glu Gly Trp 10 15 20 cca gtg gga agc ttt gaa aca tac cca gaa gcc caa gca gca gtg gat 211 Pro Val Gly Ser Phe Glu Thr Tyr Pro Glu Ala Gln Ala Ala Val Asp 25 30 35 ttg ctc agt gat aat gca ttc ccc gtc acc gaa ttg acc att gtt ggt 259 Leu Leu Ser Asp Asn Ala Phe Pro Val Thr Glu Leu Thr Ile Val Gly 40 45 50 gtg gac ctg att gaa gtg gaa cgc gtt aca ggt cgt ctc acg tgg ggt 307 Val Asp Leu Ile Glu Val Glu Arg Val Thr Gly Arg Leu Thr Trp Gly 55 60 65 cgt gtg att gcc gga gga atg gca tct ggc gca tgg ttg ggt ctg ttc 355 Arg Val Ile Ala Gly Gly Met Ala Ser Gly Ala Trp Leu Gly Leu Phe 70 75 80 85 ttt ggc att gtc atg gcc ttg atg tct gga ttc tgg ttc tct tcc atc 403 Phe Gly Ile Val Met Ala Leu Met Ser Gly Phe Trp Phe Ser Ser Ile 90 95 100 gca gcg gga ata ggt atg ggt ttg gtg ttt ggc att gtc ggt gca gca 451 Ala Ala Gly Ile Gly Met Gly Leu Val Phe Gly Ile Val Gly Ala Ala 105 110 115 gtt cct tat gct gct tcc aaa ggc aag cgg gac ttt acc tct tca act 499 Val Pro Tyr Ala Ala Ser Lys Gly Lys Arg Asp Phe Thr Ser Ser Thr 120 125 130 caa att gtg gcg ggg cgc tat gat gtg att tgt tcc cca gaa cgt gct 547 Gln Ile Val Ala Gly Arg Tyr Asp Val Ile Cys Ser Pro Glu Arg Ala 135 140 145 cgg gaa gct cga gac atg att gcc ctg aaa act cga gat ctc cgc caa 595 Arg Glu Ala Arg Asp Met Ile Ala Leu Lys Thr Arg Asp Leu Arg Gln 150 155 160 165 taagttaaac taacgcctat gaaaaatgtg 625 <210> 234 <211> 165 <212> PRT <213> Corynebacterium glutamicum <400> 234 Met Thr Gln Pro Arg Pro Asp Ala Ala Ser Val Ser Leu Glu Lys Lys 1 5 10 15 Arg Pro Glu Gly Trp Pro Val Gly Ser Phe Glu Thr Tyr Pro Glu Ala 20 25 30 Gln Ala Ala Val Asp Leu Leu Ser Asp Asn Ala Phe Pro Val Thr Glu 35 40 45 Leu Thr Ile Val Gly Val Asp Leu Ile Glu Val Glu Arg Val Thr Gly 50 55 60 Arg Leu Thr Trp Gly Arg Val Ile Ala Gly Gly Met Ala Ser Gly Ala 65 70 75 80 Trp Leu Gly Leu Phe Phe Gly Ile Val Met Ala Leu Met Ser Gly Phe 85 90 95 Trp Phe Ser Ser Ile Ala Ala Gly Ile Gly Met Gly Leu Val Phe Gly 100 105 110 Ile Val Gly Ala Ala Val Pro Tyr Ala Ala Ser Lys Gly Lys Arg Asp 115 120 125 Phe Thr Ser Ser Thr Gln Ile Val Ala Gly Arg Tyr Asp Val Ile Cys 130 135 140 Ser Pro Glu Arg Ala Arg Glu Ala Arg Asp Met Ile Ala Leu Lys Thr 145 150 155 160 Arg Asp Leu Arg Gln 165 <210> 235 <211> 1255 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1225) <223> RXA02070 <400> 235 aacagcacgg atcaggacct caagatttgt ctgaccccac tcagggtgat gttgcagacg 60 aattttaggg agtatcaaaa cttgggacta ctatcgatac gtg atg act caa gta 115 Val Met Thr Gln Val 1 5 acc gaa tcc gct gtc cgc agc gcg cta tcc cgc gta gag gat cca gag 163 Thr Glu Ser Ala Val Arg Ser Ala Leu Ser Arg Val Glu Asp Pro Glu 10 15 20 atc ggt aag ccc atc aca gag ctc ggc atg gtc aaa tca gtg tcc atc 211 Ile Gly Lys Pro Ile Thr Glu Leu Gly Met Val Lys Ser Val Ser Ile 25 30 35 gac ggc tct gat gtc cag gtg gag gtc tac ctg acg atc gcg gct tgc 259 Asp Gly Ser Asp Val Gln Val Glu Val Tyr Leu Thr Ile Ala Ala Cys 40 45 50 ccg atg aaa acc acc att gtc acc aac act gaa gca gct ctc aaa gac 307 Pro Met Lys Thr Thr Ile Val Thr Asn Thr Glu Ala Ala Leu Lys Asp 55 60 65 atc gac ggg gtt ggc caa gtt cat gtc acc acc gat gtc atg agt gat 355 Ile Asp Gly Val Gly Gln Val His Val Thr Thr Asp Val Met Ser Asp 70 75 80 85 gaa cag cgc cgt gcg ctc cgc gtc tcc ctg cgc ggt gaa act tct gag 403 Glu Gln Arg Arg Ala Leu Arg Val Ser Leu Arg Gly Glu Thr Ser Glu 90 95 100 cca gtg att cca ttc gct cag cct ggt tcc act acc cgc gtt tac gct 451 Pro Val Ile Pro Phe Ala Gln Pro Gly Ser Thr Thr Arg Val Tyr Ala 105 110 115 gtt gct tcc ggc aaa ggt ggc gta gga aaa tcc tcc atg acg gtg aac 499 Val Ala Ser Gly Lys Gly Gly Val Gly Lys Ser Ser Met Thr Val Asn 120 125 130 ttg gct gca gcc cta gcc aag cgc ggg ctg tct gtg gga att ttg gat 547 Leu Ala Ala Ala Leu Ala Lys Arg Gly Leu Ser Val Gly Ile Leu Asp 135 140 145 gcc gat att tac gga cac tca gtg ccc gga atg ctc ggc tcg gac caa 595 Ala Asp Ile Tyr Gly His Ser Val Pro Gly Met Leu Gly Ser Asp Gln 150 155 160 165 cgc cca cac cag gtc gat gac atg atc atg cct ccc cag gcg cac ggc 643 Arg Pro His Gln Val Asp Asp Met Ile Met Pro Pro Gln Ala His Gly 170 175 180 gtg aag atg ata tcc att gct cac ttc acc gaa gga aat gct cct gtg 691 Val Lys Met Ile Ser Ile Ala His Phe Thr Glu Gly Asn Ala Pro Val 185 190 195 gtg tgg cgt gga cca atg ctg cac cgt gcc atc cag caa ttc ctc act 739 Val Trp Arg Gly Pro Met Leu His Arg Ala Ile Gln Gln Phe Leu Thr 200 205 210 gac gtg ttc tgg ggc gac ctg gat att ttg ctg ctg gat ctt cct cca 787 Asp Val Phe Trp Gly Asp Leu Asp Ile Leu Leu Leu Asp Leu Pro Pro 215 220 225 gga act ggt gac atc gcc atc acc gtt gcc caa ttg atc ccg aat gct 835 Gly Thr Gly Asp Ile Ala Ile Thr Val Ala Gln Leu Ile Pro Asn Ala 230 235 240 245 gag ttg ctc att gtg acc act cct cag gct gcc gca gct gag gtt gcc 883 Glu Leu Leu Ile Val Thr Thr Pro Gln Ala Ala Ala Ala Glu Val Ala 250 255 260 gag cga gca gga acg atc tct gtg cag acc aac cag aag gtt gct ggc 931 Glu Arg Ala Gly Thr Ile Ser Val Gln Thr Asn Gln Lys Val Ala Gly 265 270 275 gtg att gaa aac atg tct gcc atg gtg ctt cct gat ggc acc acc atg 979 Val Ile Glu Asn Met Ser Ala Met Val Leu Pro Asp Gly Thr Thr Met 280 285 290 gat gtt ttc ggc acc ggc ggc ggt caa aag att gct gat cgt ctt acc 1027 Asp Val Phe Gly Thr Gly Gly Gly Gln Lys Ile Ala Asp Arg Leu Thr 295 300 305 gct gtg aca ggt gaa gag gtc aag gtt atc gga tct gtt cca ttg gat 1075 Ala Val Thr Gly Glu Glu Val Lys Val Ile Gly Ser Val Pro Leu Asp 310 315 320 325 ccg aac ctg cgt atc ggt ggc gat gtg gga aat cct att gcg att tct 1123 Pro Asn Leu Arg Ile Gly Gly Asp Val Gly Asn Pro Ile Ala Ile Ser 330 335 340 gaa cca cac tcc cca acc gct gca gcg atc aat gag atc gct gaa cac 1171 Glu Pro His Ser Pro Thr Ala Ala Ala Ile Asn Glu Ile Ala Glu His 345 350 355 cta gct cac cgc aag gta tcg ctg gtg ggt aaa acg ctt ggg ctt ggc 1219 Leu Ala His Arg Lys Val Ser Leu Val Gly Lys Thr Leu Gly Leu Gly 360 365 370 gtt aaa taaaagctaa ataatatcgg tccaagagac 1255 Val Lys 375 <210> 236 <211> 375 <212> PRT <213> Corynebacterium glutamicum <400> 236 Val Met Thr Gln Val Thr Glu Ser Ala Val Arg Ser Ala Leu Ser Arg 1 5 10 15 Val Glu Asp Pro Glu Ile Gly Lys Pro Ile Thr Glu Leu Gly Met Val 20 25 30 Lys Ser Val Ser Ile Asp Gly Ser Asp Val Gln Val Glu Val Tyr Leu 35 40 45 Thr Ile Ala Ala Cys Pro Met Lys Thr Thr Ile Val Thr Asn Thr Glu 50 55 60 Ala Ala Leu Lys Asp Ile Asp Gly Val Gly Gln Val His Val Thr Thr 65 70 75 80 Asp Val Met Ser Asp Glu Gln Arg Arg Ala Leu Arg Val Ser Leu Arg 85 90 95 Gly Glu Thr Ser Glu Pro Val Ile Pro Phe Ala Gln Pro Gly Ser Thr 100 105 110 Thr Arg Val Tyr Ala Val Ala Ser Gly Lys Gly Gly Val Gly Lys Ser 115 120 125 Ser Met Thr Val Asn Leu Ala Ala Ala Leu Ala Lys Arg Gly Leu Ser 130 135 140 Val Gly Ile Leu Asp Ala Asp Ile Tyr Gly His Ser Val Pro Gly Met 145 150 155 160 Leu Gly Ser Asp Gln Arg Pro His Gln Val Asp Asp Met Ile Met Pro 165 170 175 Pro Gln Ala His Gly Val Lys Met Ile Ser Ile Ala His Phe Thr Glu 180 185 190 Gly Asn Ala Pro Val Val Trp Arg Gly Pro Met Leu His Arg Ala Ile 195 200 205 Gln Gln Phe Leu Thr Asp Val Phe Trp Gly Asp Leu Asp Ile Leu Leu 210 215 220 Leu Asp Leu Pro Pro Gly Thr Gly Asp Ile Ala Ile Thr Val Ala Gln 225 230 235 240 Leu Ile Pro Asn Ala Glu Leu Leu Ile Val Thr Thr Pro Gln Ala Ala 245 250 255 Ala Ala Glu Val Ala Glu Arg Ala Gly Thr Ile Ser Val Gln Thr Asn 260 265 270 Gln Lys Val Ala Gly Val Ile Glu Asn Met Ser Ala Met Val Leu Pro 275 280 285 Asp Gly Thr Thr Met Asp Val Phe Gly Thr Gly Gly Gly Gln Lys Ile 290 295 300 Ala Asp Arg Leu Thr Ala Val Thr Gly Glu Glu Val Lys Val Ile Gly 305 310 315 320 Ser Val Pro Leu Asp Pro Asn Leu Arg Ile Gly Gly Asp Val Gly Asn 325 330 335 Pro Ile Ala Ile Ser Glu Pro His Ser Pro Thr Ala Ala Ala Ile Asn 340 345 350 Glu Ile Ala Glu His Leu Ala His Arg Lys Val Ser Leu Val Gly Lys 355 360 365 Thr Leu Gly Leu Gly Val Lys 370 375 <210> 237 <211> 475 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(445) <223> RXA02084 <400> 237 cgttgatggt tgggtggtgg gtcacagttt agaaaaagtg acttcaaatc acgtcgaaaa 60 gaaattgaaa gtacttaaga aacatgtcac gctaggagac gtg ata atc att gca 115 Val Ile Ile Ile Ala 1 5 agc gtt gtt ttc ctc ctc gtt ggc gca atg ttg gcg aat gct gcc gct 163 Ser Val Val Phe Leu Leu Val Gly Ala Met Leu Ala Asn Ala Ala Ala 10 15 20 gcg ctc ttt agt gcc agc gag cca ttc gga cga att tcc tac ctc att 211 Ala Leu Phe Ser Ala Ser Glu Pro Phe Gly Arg Ile Ser Tyr Leu Ile 25 30 35 ggc cta cct aac gaa gac gac ttc gtg ccg tac tca cta cgg ttc gtg 259 Gly Leu Pro Asn Glu Asp Asp Phe Val Pro Tyr Ser Leu Arg Phe Val 40 45 50 gcc ttt ttc cca ctg atg ctc tcc gca tcg atg gca gca tcc ttc ttc 307 Ala Phe Phe Pro Leu Met Leu Ser Ala Ser Met Ala Ala Ser Phe Phe 55 60 65 ggg gtg tgg gca gta cta atc att cct ttc ggt tac ttc cca tca ctg 355 Gly Val Trp Ala Val Leu Ile Ile Pro Phe Gly Tyr Phe Pro Ser Leu 70 75 80 85 atg atg gtt cat aag cac aac aag cag gta cag cga acc tgg gat tcc 403 Met Met Val His Lys His Asn Lys Gln Val Gln Arg Thr Trp Asp Ser 90 95 100 gtc acc gtt gct gac ttc tac gag gat tcc acc cct ctg gtc 445 Val Thr Val Ala Asp Phe Tyr Glu Asp Ser Thr Pro Leu Val 105 110 115 taatttcgat ttctaaatgt catattggcc 475 <210> 238 <211> 115 <212> PRT <213> Corynebacterium glutamicum <400> 238 Val Ile Ile Ile Ala Ser Val Val Phe Leu Leu Val Gly Ala Met Leu 1 5 10 15 Ala Asn Ala Ala Ala Ala Leu Phe Ser Ala Ser Glu Pro Phe Gly Arg 20 25 30 Ile Ser Tyr Leu Ile Gly Leu Pro Asn Glu Asp Asp Phe Val Pro Tyr 35 40 45 Ser Leu Arg Phe Val Ala Phe Phe Pro Leu Met Leu Ser Ala Ser Met 50 55 60 Ala Ala Ser Phe Phe Gly Val Trp Ala Val Leu Ile Ile Pro Phe Gly 65 70 75 80 Tyr Phe Pro Ser Leu Met Met Val His Lys His Asn Lys Gln Val Gln 85 90 95 Arg Thr Trp Asp Ser Val Thr Val Ala Asp Phe Tyr Glu Asp Ser Thr 100 105 110 Pro Leu Val 115 <210> 239 <211> 781 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(751) <223> RXA02091 <400> 239 agatctagcc aacgaacttg atttcatcga gccggaagag acagaagaag agcagcaatt 60 gaagtggctt agccttatgc agttttttgg aagtagataa atg agc atc tgg aaa 115 Met Ser Ile Trp Lys 1 5 cgt ctg tta gtg cag tac ccg cgc ttc gcc gac acc ctc aca gcc ggc 163 Arg Leu Leu Val Gln Tyr Pro Arg Phe Ala Asp Thr Leu Thr Ala Gly 10 15 20 caa ccc atc acg ctc gag gaa tta gca acc ccg gaa gtg atc ttg gaa 211 Gln Pro Ile Thr Leu Glu Glu Leu Ala Thr Pro Glu Val Ile Leu Glu 25 30 35 gct gtt gcc aaa ggc caa gaa att ttc ggc att gag cag cca aaa cat 259 Ala Val Ala Lys Gly Gln Glu Ile Phe Gly Ile Glu Gln Pro Lys His 40 45 50 gca gca caa ctc tgg ttt cac tcc ctg tgc acc gca att gtc ggc ccc 307 Ala Ala Gln Leu Trp Phe His Ser Leu Cys Thr Ala Ile Val Gly Pro 55 60 65 gcc gtc acc gcc atg gtg gaa ttc gat gtc atc ccc agc ctc gac ata 355 Ala Val Thr Ala Met Val Glu Phe Asp Val Ile Pro Ser Leu Asp Ile 70 75 80 85 cgt cga ggt cag ctg cat aac atc gac ggt tac tgg ttc ggc ttc agg 403 Arg Arg Gly Gln Leu His Asn Ile Asp Gly Tyr Trp Phe Gly Phe Arg 90 95 100 ccg gag gag atg ctt gtc gac gcc tcc ctc cac ctg tcg ggc acc caa 451 Pro Glu Glu Met Leu Val Asp Ala Ser Leu His Leu Ser Gly Thr Gln 105 110 115 ttc ggc gag agt atc cgc gtg gtg att gat gca tta tgc gct gcc acg 499 Phe Gly Glu Ser Ile Arg Val Val Ile Asp Ala Leu Cys Ala Ala Thr 120 125 130 gat ctg cga ccg gca ccc ctg tgg gcg gtt gcc tca gat gcg ttg gga 547 Asp Leu Arg Pro Ala Pro Leu Trp Ala Val Ala Ser Asp Ala Leu Gly 135 140 145 atc gca gct agc ggc gca ggt gtc gag gcc ttt gaa gaa gaa cat gcc 595 Ile Ala Ala Ser Gly Ala Gly Val Glu Ala Phe Glu Glu Glu His Ala 150 155 160 165 cgc gag gtg gcg gaa gcc ctc att gaa gga atg aat agt gtg aac tca 643 Arg Glu Val Ala Glu Ala Leu Ile Glu Gly Met Asn Ser Val Asn Ser 170 175 180 gtt cca tcg ccg cgg ttt aac gac gac gat tat ttc att cga gct gga 691 Val Pro Ser Pro Arg Phe Asn Asp Asp Asp Tyr Phe Ile Arg Ala Gly 185 190 195 tgc tgc atg att ttc cac tca cca cga gct gat ttt tgc acg tcg tgc 739 Cys Cys Met Ile Phe His Ser Pro Arg Ala Asp Phe Cys Thr Ser Cys 200 205 210 cca cag aag agg tgaaaggcta ggcgcggatt cgttgtggac 781 Pro Gln Lys Arg 215 <210> 240 <211> 217 <212> PRT <213> Corynebacterium glutamicum <400> 240 Met Ser Ile Trp Lys Arg Leu Leu Val Gln Tyr Pro Arg Phe Ala Asp 1 5 10 15 Thr Leu Thr Ala Gly Gln Pro Ile Thr Leu Glu Glu Leu Ala Thr Pro 20 25 30 Glu Val Ile Leu Glu Ala Val Ala Lys Gly Gln Glu Ile Phe Gly Ile 35 40 45 Glu Gln Pro Lys His Ala Ala Gln Leu Trp Phe His Ser Leu Cys Thr 50 55 60 Ala Ile Val Gly Pro Ala Val Thr Ala Met Val Glu Phe Asp Val Ile 65 70 75 80 Pro Ser Leu Asp Ile Arg Arg Gly Gln Leu His Asn Ile Asp Gly Tyr 85 90 95 Trp Phe Gly Phe Arg Pro Glu Glu Met Leu Val Asp Ala Ser Leu His 100 105 110 Leu Ser Gly Thr Gln Phe Gly Glu Ser Ile Arg Val Val Ile Asp Ala 115 120 125 Leu Cys Ala Ala Thr Asp Leu Arg Pro Ala Pro Leu Trp Ala Val Ala 130 135 140 Ser Asp Ala Leu Gly Ile Ala Ala Ser Gly Ala Gly Val Glu Ala Phe 145 150 155 160 Glu Glu Glu His Ala Arg Glu Val Ala Glu Ala Leu Ile Glu Gly Met 165 170 175 Asn Ser Val Asn Ser Val Pro Ser Pro Arg Phe Asn Asp Asp Asp Tyr 180 185 190 Phe Ile Arg Ala Gly Cys Cys Met Ile Phe His Ser Pro Arg Ala Asp 195 200 205 Phe Cys Thr Ser Cys Pro Gln Lys Arg 210 215 <210> 241 <211> 3502 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3472) <223> RXA02097 <400> 241 ttggctacag atgtttcagc gcttgcagtg gggtagtgtg tttaaacatc acaattagtt 60 ctagaggaaa acgcattttt tgcgcgggga gagtgtatac atg ccg gct ggc atc 115 Met Pro Ala Gly Ile 1 5 gca gac atg aca gat tca ttg ctc gga tgg gca tca caa act gag ctg 163 Ala Asp Met Thr Asp Ser Leu Leu Gly Trp Ala Ser Gln Thr Glu Leu 10 15 20 gat ctg aac cag cgt ctt gca ggg gta gag tac ttt cca caa att cag 211 Asp Leu Asn Gln Arg Leu Ala Gly Val Glu Tyr Phe Pro Gln Ile Gln 25 30 35 ctg cga cac gat gag ctc gag cgc att cat cgg ttt tac ggc acc ttt 259 Leu Arg His Asp Glu Leu Glu Arg Ile His Arg Phe Tyr Gly Thr Phe 40 45 50 ttg tcc cgc cag gta ggc gcg ggc gca agc ctt ggg gat ctt ttt gaa 307 Leu Ser Arg Gln Val Gly Ala Gly Ala Ser Leu Gly Asp Leu Phe Glu 55 60 65 atg acc cca tgc ctg aca gtc acc acc ttg gtg tct cgg gcg tca cgg 355 Met Thr Pro Cys Leu Thr Val Thr Thr Leu Val Ser Arg Ala Ser Arg 70 75 80 85 atc agc gat cca gca gat ttc ttc ggt gaa tac atc gga gga ctg gga 403 Ile Ser Asp Pro Ala Asp Phe Phe Gly Glu Tyr Ile Gly Gly Leu Gly 90 95 100 ctt agc gca gaa cac gca gca gtt gtt gaa ggg ttg acc gaa aag ctc 451 Leu Ser Ala Glu His Ala Ala Val Val Glu Gly Leu Thr Glu Lys Leu 105 110 115 ttc gca cag gct ggc ctg ctc gtt cct gag gga att gca tct cca ttg 499 Phe Ala Gln Ala Gly Leu Leu Val Pro Glu Gly Ile Ala Ser Pro Leu 120 125 130 gag ttg tta tcc atc cac gca ggc att agt aac cac gaa gtg gcc gca 547 Glu Leu Leu Ser Ile His Ala Gly Ile Ser Asn His Glu Val Ala Ala 135 140 145 gtg ctg acc gaa gtg gaa aac ggc acc acc gaa tat cca ttc atg ttc 595 Val Leu Thr Glu Val Glu Asn Gly Thr Thr Glu Tyr Pro Phe Met Phe 150 155 160 165 gac gct gtc ctg cgc cta acc cct gag tgg gca cag acc ctt atc ggc 643 Asp Ala Val Leu Arg Leu Thr Pro Glu Trp Ala Gln Thr Leu Ile Gly 170 175 180 gga gtt caa gaa ctc att gaa ttt gcc acc acc cac cga act tct tgg 691 Gly Val Gln Glu Leu Ile Glu Phe Ala Thr Thr His Arg Thr Ser Trp 185 190 195 tca gac cgc cag cgc gaa tcc tca ctg cca gcc atg atc gat gag atc 739 Ser Asp Arg Gln Arg Glu Ser Ser Leu Pro Ala Met Ile Asp Glu Ile 200 205 210 gtt gtg gcg gaa ctt cgg gaa cgc cca gtt ggt act gcc gac cgt gaa 787 Val Val Ala Glu Leu Arg Glu Arg Pro Val Gly Thr Ala Asp Arg Glu 215 220 225 aac tcc gtt ggt gtg gca ctt cgt gag ctt cgc cca cgc ctc atc ctg 835 Asn Ser Val Gly Val Ala Leu Arg Glu Leu Arg Pro Arg Leu Ile Leu 230 235 240 245 gat gca gaa cgc cgc aaa gtc tgc ctg cgt cta cct gaa cag cgc gtc 883 Asp Ala Glu Arg Arg Lys Val Cys Leu Arg Leu Pro Glu Gln Arg Val 250 255 260 agc gac gat gaa atc aac tgg cga gtc agc cta gaa ggc acc acc cgg 931 Ser Asp Asp Glu Ile Asn Trp Arg Val Ser Leu Glu Gly Thr Thr Arg 265 270 275 att ttc tcc acc cgc cga gca tgg ggc gat act tct gga tac tcc gaa 979 Ile Phe Ser Thr Arg Arg Ala Trp Gly Asp Thr Ser Gly Tyr Ser Glu 280 285 290 gcc ctc gac atc act gtc gag cgt caa atc cgc gaa acc acc gtc acc 1027 Ala Leu Asp Ile Thr Val Glu Arg Gln Ile Arg Glu Thr Thr Val Thr 295 300 305 gac acc tca aac caa atc acc tgg gtt gtc cca gtc gtg gac ttc aac 1075 Asp Thr Ser Asn Gln Ile Thr Trp Val Val Pro Val Val Asp Phe Asn 310 315 320 325 gac cca gtg ctg gtg ttt tcc gcg cgc ggt gaa aac ctc acc gac aag 1123 Asp Pro Val Leu Val Phe Ser Ala Arg Gly Glu Asn Leu Thr Asp Lys 330 335 340 gtc tcc ctg cac cat caa gag att tac gtt ctc gcg cca gcg gaa gca 1171 Val Ser Leu His His Gln Glu Ile Tyr Val Leu Ala Pro Ala Glu Ala 345 350 355 aaa ctc gaa gac atg gtc act ggc cag cca gta cca gtt att gag caa 1219 Lys Leu Glu Asp Met Val Thr Gly Gln Pro Val Pro Val Ile Glu Gln 360 365 370 ttc ctc gta gag ggc tgg aac tca tgg gtg tgc tcc cgc gtg gac gcc 1267 Phe Leu Val Glu Gly Trp Asn Ser Trp Val Cys Ser Arg Val Asp Ala 375 380 385 cgt ggc ctg tcc tct ctg aag gtc aac aaa gaa gtc cga tgc att gac 1315 Arg Gly Leu Ser Ser Leu Lys Val Asn Lys Glu Val Arg Cys Ile Asp 390 395 400 405 cca cgt cga cgc gtt gcc ttc cac cac cca gcc gaa ttg gtc cct cac 1363 Pro Arg Arg Arg Val Ala Phe His His Pro Ala Glu Leu Val Pro His 410 415 420 gta cga tcc att tcc gga ctc ccc gta cac gcg cag tcc ctg atc gcc 1411 Val Arg Ser Ile Ser Gly Leu Pro Val His Ala Gln Ser Leu Ile Ala 425 430 435 gag ttc cca cca acc ctg agc gga caa gac gaa acc tgg atg ctc tcc 1459 Glu Phe Pro Pro Thr Leu Ser Gly Gln Asp Glu Thr Trp Met Leu Ser 440 445 450 atc tcg gct ttc gca ggt gta ggc gct gct ggt gaa gaa atc gcc gag 1507 Ile Ser Ala Phe Ala Gly Val Gly Ala Ala Gly Glu Glu Ile Ala Glu 455 460 465 cca gag cct ttg gaa gtc cct gcc gac ggt ggc ctt ttc gcc atc ttc 1555 Pro Glu Pro Leu Glu Val Pro Ala Asp Gly Gly Leu Phe Ala Ile Phe 470 475 480 485 gac cca gaa ata tac gac gcc cca tgg gtg ggt gaa tac ctg gtc cga 1603 Asp Pro Glu Ile Tyr Asp Ala Pro Trp Val Gly Glu Tyr Leu Val Arg 490 495 500 ctc cgc ggc cca cgc aat gaa tcc ttc cga ccc gaa ttc gcc atc gtc 1651 Leu Arg Gly Pro Arg Asn Glu Ser Phe Arg Pro Glu Phe Ala Ile Val 505 510 515 gaa gac atg acc acc gaa ttc gaa gtc gcc tca ggt gca tca ttt cga 1699 Glu Asp Met Thr Thr Glu Phe Glu Val Ala Ser Gly Ala Ser Phe Arg 520 525 530 atc cca acc acc act ggt ctc agc gaa gcc agc cta cgc gtg cgt tcc 1747 Ile Pro Thr Thr Thr Gly Leu Ser Glu Ala Ser Leu Arg Val Arg Ser 535 540 545 ggt gaa aag cac ttc acc gca gag cca cgc ctg gtc acc gtt gaa gca 1795 Gly Glu Lys His Phe Thr Ala Glu Pro Arg Leu Val Thr Val Glu Ala 550 555 560 565 acc gac ccc aac gca tca ttc gtg gtc acc acc gat gaa ggc gat caa 1843 Thr Asp Pro Asn Ala Ser Phe Val Val Thr Thr Asp Glu Gly Asp Gln 570 575 580 atg cca ttg cga ttt gtg cca cca caa atc gcc atc gaa ctt cca ctg 1891 Met Pro Leu Arg Phe Val Pro Pro Gln Ile Ala Ile Glu Leu Pro Leu 585 590 595 acc acc gag cca cca acc tgg cgc gtc acc cgt act gtc tgt gga cca 1939 Thr Thr Glu Pro Pro Thr Trp Arg Val Thr Arg Thr Val Cys Gly Pro 600 605 610 cgc gac ctc gac ggt gca ggc gaa ctc cgc atc cgc acc ggt gtc gat 1987 Arg Asp Leu Asp Gly Ala Gly Glu Leu Arg Ile Arg Thr Gly Val Asp 615 620 625 gtc ggc gat cca aag gtc agt gtg cgc aac cac cac ggt tca cca ctg 2035 Val Gly Asp Pro Lys Val Ser Val Arg Asn His His Gly Ser Pro Leu 630 635 640 645 cga acc gtg aaa atg gtc acc cct gac aac ggc cgt acc tgg att gcc 2083 Arg Thr Val Lys Met Val Thr Pro Asp Asn Gly Arg Thr Trp Ile Ala 650 655 660 agc atg aag gaa atc gca gcc agt acc ttt gtg atg cca cgc gga tcc 2131 Ser Met Lys Glu Ile Ala Ala Ser Thr Phe Val Met Pro Arg Gly Ser 665 670 675 atc gaa ttt gag tgg act gac cgc aag gtt gac cgt cgc gtt tcc gtg 2179 Ile Glu Phe Glu Trp Thr Asp Arg Lys Val Asp Arg Arg Val Ser Val 680 685 690 acg att gct gtc att gac aaa act gag aac ttt act ggc atc acc atc 2227 Thr Ile Ala Val Ile Asp Lys Thr Glu Asn Phe Thr Gly Ile Thr Ile 695 700 705 gaa gat gga aag ctc gta ttc gaa gaa ctc gca gcc ggt cgc caa ctc 2275 Glu Asp Gly Lys Leu Val Phe Glu Glu Leu Ala Ala Gly Arg Gln Leu 710 715 720 725 gct gca tgg gtg tgg cca caa acc gca ccg tgg gta agc gca gtg gaa 2323 Ala Ala Trp Val Trp Pro Gln Thr Ala Pro Trp Val Ser Ala Val Glu 730 735 740 ctt gct gtc acc gga cca gag ctg gaa ctc cct gaa gtt ctc gtc ggc 2371 Leu Ala Val Thr Gly Pro Glu Leu Glu Leu Pro Glu Val Leu Val Gly 745 750 755 gca ggc aac ctg att gtt caa ctc cac acc gct gac cca ttc act acc 2419 Ala Gly Asn Leu Ile Val Gln Leu His Thr Ala Asp Pro Phe Thr Thr 760 765 770 tcc gtg acc cca ctg tca cca gga aaa gct gcg gtc acc gtt gag caa 2467 Ser Val Thr Pro Leu Ser Pro Gly Lys Ala Ala Val Thr Val Glu Gln 775 780 785 gaa ggc tac tac tca gca caa acc gaa gaa tat gca cag ctt tca gca 2515 Glu Gly Tyr Tyr Ser Ala Gln Thr Glu Glu Tyr Ala Gln Leu Ser Ala 790 795 800 805 ttc ttc ggt ggg gaa gta gaa gaa cca cca atc agt gac gct gtg gtc 2563 Phe Phe Gly Gly Glu Val Glu Glu Pro Pro Ile Ser Asp Ala Val Val 810 815 820 ccc gca ctt tgg gat gtt tcc cat atc tgg acc gaa cag gga aac acc 2611 Pro Ala Leu Trp Asp Val Ser His Ile Trp Thr Glu Gln Gly Asn Thr 825 830 835 gag cat ctt cca gta gtc cat gcc gcc ctg cgc tcc tca cca gcc gca 2659 Glu His Leu Pro Val Val His Ala Ala Leu Arg Ser Ser Pro Ala Ala 840 845 850 gca ctg aag ggt ctg tcc gct tcg ctg gtt ccc gca cag gca cta cct 2707 Ala Leu Lys Gly Leu Ser Ala Ser Leu Val Pro Ala Gln Ala Leu Pro 855 860 865 gga aaa gtc att tcc tcc gga ctg gca gcc tca ccg ttc acc acg gaa 2755 Gly Lys Val Ile Ser Ser Gly Leu Ala Ala Ser Pro Phe Thr Thr Glu 870 875 880 885 tca cca gca aca gaa gtg cac cgc acc gca tgg atc gga acc ctg caa 2803 Ser Pro Ala Thr Glu Val His Arg Thr Ala Trp Ile Gly Thr Leu Gln 890 895 900 ctc ctg ggt gca ctg cca agc gca ttc aag gaa gcc gaa gag ctt ggc 2851 Leu Leu Gly Ala Leu Pro Ser Ala Phe Lys Glu Ala Glu Glu Leu Gly 905 910 915 aac cgc aca cca ctg ctg cca atc ctc gga caa ctt gag gaa gtc gcc 2899 Asn Arg Thr Pro Leu Leu Pro Ile Leu Gly Gln Leu Glu Glu Val Ala 920 925 930 ggc aag aac atc ctg tcc acc ctt gca act ggc cgt gac tcc act ttg 2947 Gly Lys Asn Ile Leu Ser Thr Leu Ala Thr Gly Arg Asp Ser Thr Leu 935 940 945 gac acc gca tgc atc gac caa tcc acc gtt gcg att gcc ggc atg aac 2995 Asp Thr Ala Cys Ile Asp Gln Ser Thr Val Ala Ile Ala Gly Met Asn 950 955 960 965 gaa acc cag caa aaa gcc ctg ctg gac atg ttc ttc agc aac gcc gac 3043 Glu Thr Gln Gln Lys Ala Leu Leu Asp Met Phe Phe Ser Asn Ala Asp 970 975 980 atc gtt cct gga cca cta atg gaa gac aac acc cgc ctc atg gca gtg 3091 Ile Val Pro Gly Pro Leu Met Glu Asp Asn Thr Arg Leu Met Ala Val 985 990 995 ttc gaa acc ttc aag aag cgc gat gca ctc cgt gag gtt ctc cag act 3139 Phe Glu Thr Phe Lys Lys Arg Asp Ala Leu Arg Glu Val Leu Gln Thr 1000 1005 1010 gaa ggc ttg att aag acc gct gta gaa ctt ctt cgt gcc atg cgt gga 3187 Glu Gly Leu Ile Lys Thr Ala Val Glu Leu Leu Arg Ala Met Arg Gly 1015 1020 1025 acc cag cgt cag ctg tat tcc tcc gca cgt att cga ttc gac aag ctc 3235 Thr Gln Arg Gln Leu Tyr Ser Ser Ala Arg Ile Arg Phe Asp Lys Leu 1030 1035 1040 1045 gat ggt gtc aac act gac aac cca gaa aac atg tgg gca ctc acc cca 3283 Asp Gly Val Asn Thr Asp Asn Pro Glu Asn Met Trp Ala Leu Thr Pro 1050 1055 1060 gtt gtg tca ctg gtg ttc gcg ttg tca tcc cgt ttg cat gca cac gaa 3331 Val Val Ser Leu Val Phe Ala Leu Ser Ser Arg Leu His Ala His Glu 1065 1070 1075 ttg atc ggc aag acc cga act ctc gat cgt gca tct gcc ggt tgg ggt 3379 Leu Ile Gly Lys Thr Arg Thr Leu Asp Arg Ala Ser Ala Gly Trp Gly 1080 1085 1090 cga atc gct gat ctg gtg cca gac ctt gtc acc ggt gac ttg atc tcc 3427 Arg Ile Ala Asp Leu Val Pro Asp Leu Val Thr Gly Asp Leu Ile Ser 1095 1100 1105 gcg gag gca atg gtt ttg gga gct cga aac cca gga ctc gtc gat 3472 Ala Glu Ala Met Val Leu Gly Ala Arg Asn Pro Gly Leu Val Asp 1110 1115 1120 tagtccctga tttcatcgga gggcacctag 3502 <210> 242 <211> 1124 <212> PRT <213> Corynebacterium glutamicum <400> 242 Met Pro Ala Gly Ile Ala Asp Met Thr Asp Ser Leu Leu Gly Trp Ala 1 5 10 15 Ser Gln Thr Glu Leu Asp Leu Asn Gln Arg Leu Ala Gly Val Glu Tyr 20 25 30 Phe Pro Gln Ile Gln Leu Arg His Asp Glu Leu Glu Arg Ile His Arg 35 40 45 Phe Tyr Gly Thr Phe Leu Ser Arg Gln Val Gly Ala Gly Ala Ser Leu 50 55 60 Gly Asp Leu Phe Glu Met Thr Pro Cys Leu Thr Val Thr Thr Leu Val 65 70 75 80 Ser Arg Ala Ser Arg Ile Ser Asp Pro Ala Asp Phe Phe Gly Glu Tyr 85 90 95 Ile Gly Gly Leu Gly Leu Ser Ala Glu His Ala Ala Val Val Glu Gly 100 105 110 Leu Thr Glu Lys Leu Phe Ala Gln Ala Gly Leu Leu Val Pro Glu Gly 115 120 125 Ile Ala Ser Pro Leu Glu Leu Leu Ser Ile His Ala Gly Ile Ser Asn 130 135 140 His Glu Val Ala Ala Val Leu Thr Glu Val Glu Asn Gly Thr Thr Glu 145 150 155 160 Tyr Pro Phe Met Phe Asp Ala Val Leu Arg Leu Thr Pro Glu Trp Ala 165 170 175 Gln Thr Leu Ile Gly Gly Val Gln Glu Leu Ile Glu Phe Ala Thr Thr 180 185 190 His Arg Thr Ser Trp Ser Asp Arg Gln Arg Glu Ser Ser Leu Pro Ala 195 200 205 Met Ile Asp Glu Ile Val Val Ala Glu Leu Arg Glu Arg Pro Val Gly 210 215 220 Thr Ala Asp Arg Glu Asn Ser Val Gly Val Ala Leu Arg Glu Leu Arg 225 230 235 240 Pro Arg Leu Ile Leu Asp Ala Glu Arg Arg Lys Val Cys Leu Arg Leu 245 250 255 Pro Glu Gln Arg Val Ser Asp Asp Glu Ile Asn Trp Arg Val Ser Leu 260 265 270 Glu Gly Thr Thr Arg Ile Phe Ser Thr Arg Arg Ala Trp Gly Asp Thr 275 280 285 Ser Gly Tyr Ser Glu Ala Leu Asp Ile Thr Val Glu Arg Gln Ile Arg 290 295 300 Glu Thr Thr Val Thr Asp Thr Ser Asn Gln Ile Thr Trp Val Val Pro 305 310 315 320 Val Val Asp Phe Asn Asp Pro Val Leu Val Phe Ser Ala Arg Gly Glu 325 330 335 Asn Leu Thr Asp Lys Val Ser Leu His His Gln Glu Ile Tyr Val Leu 340 345 350 Ala Pro Ala Glu Ala Lys Leu Glu Asp Met Val Thr Gly Gln Pro Val 355 360 365 Pro Val Ile Glu Gln Phe Leu Val Glu Gly Trp Asn Ser Trp Val Cys 370 375 380 Ser Arg Val Asp Ala Arg Gly Leu Ser Ser Leu Lys Val Asn Lys Glu 385 390 395 400 Val Arg Cys Ile Asp Pro Arg Arg Arg Val Ala Phe His His Pro Ala 405 410 415 Glu Leu Val Pro His Val Arg Ser Ile Ser Gly Leu Pro Val His Ala 420 425 430 Gln Ser Leu Ile Ala Glu Phe Pro Pro Thr Leu Ser Gly Gln Asp Glu 435 440 445 Thr Trp Met Leu Ser Ile Ser Ala Phe Ala Gly Val Gly Ala Ala Gly 450 455 460 Glu Glu Ile Ala Glu Pro Glu Pro Leu Glu Val Pro Ala Asp Gly Gly 465 470 475 480 Leu Phe Ala Ile Phe Asp Pro Glu Ile Tyr Asp Ala Pro Trp Val Gly 485 490 495 Glu Tyr Leu Val Arg Leu Arg Gly Pro Arg Asn Glu Ser Phe Arg Pro 500 505 510 Glu Phe Ala Ile Val Glu Asp Met Thr Thr Glu Phe Glu Val Ala Ser 515 520 525 Gly Ala Ser Phe Arg Ile Pro Thr Thr Thr Gly Leu Ser Glu Ala Ser 530 535 540 Leu Arg Val Arg Ser Gly Glu Lys His Phe Thr Ala Glu Pro Arg Leu 545 550 555 560 Val Thr Val Glu Ala Thr Asp Pro Asn Ala Ser Phe Val Val Thr Thr 565 570 575 Asp Glu Gly Asp Gln Met Pro Leu Arg Phe Val Pro Pro Gln Ile Ala 580 585 590 Ile Glu Leu Pro Leu Thr Thr Glu Pro Pro Thr Trp Arg Val Thr Arg 595 600 605 Thr Val Cys Gly Pro Arg Asp Leu Asp Gly Ala Gly Glu Leu Arg Ile 610 615 620 Arg Thr Gly Val Asp Val Gly Asp Pro Lys Val Ser Val Arg Asn His 625 630 635 640 His Gly Ser Pro Leu Arg Thr Val Lys Met Val Thr Pro Asp Asn Gly 645 650 655 Arg Thr Trp Ile Ala Ser Met Lys Glu Ile Ala Ala Ser Thr Phe Val 660 665 670 Met Pro Arg Gly Ser Ile Glu Phe Glu Trp Thr Asp Arg Lys Val Asp 675 680 685 Arg Arg Val Ser Val Thr Ile Ala Val Ile Asp Lys Thr Glu Asn Phe 690 695 700 Thr Gly Ile Thr Ile Glu Asp Gly Lys Leu Val Phe Glu Glu Leu Ala 705 710 715 720 Ala Gly Arg Gln Leu Ala Ala Trp Val Trp Pro Gln Thr Ala Pro Trp 725 730 735 Val Ser Ala Val Glu Leu Ala Val Thr Gly Pro Glu Leu Glu Leu Pro 740 745 750 Glu Val Leu Val Gly Ala Gly Asn Leu Ile Val Gln Leu His Thr Ala 755 760 765 Asp Pro Phe Thr Thr Ser Val Thr Pro Leu Ser Pro Gly Lys Ala Ala 770 775 780 Val Thr Val Glu Gln Glu Gly Tyr Tyr Ser Ala Gln Thr Glu Glu Tyr 785 790 795 800 Ala Gln Leu Ser Ala Phe Phe Gly Gly Glu Val Glu Glu Pro Pro Ile 805 810 815 Ser Asp Ala Val Val Pro Ala Leu Trp Asp Val Ser His Ile Trp Thr 820 825 830 Glu Gln Gly Asn Thr Glu His Leu Pro Val Val His Ala Ala Leu Arg 835 840 845 Ser Ser Pro Ala Ala Ala Leu Lys Gly Leu Ser Ala Ser Leu Val Pro 850 855 860 Ala Gln Ala Leu Pro Gly Lys Val Ile Ser Ser Gly Leu Ala Ala Ser 865 870 875 880 Pro Phe Thr Thr Glu Ser Pro Ala Thr Glu Val His Arg Thr Ala Trp 885 890 895 Ile Gly Thr Leu Gln Leu Leu Gly Ala Leu Pro Ser Ala Phe Lys Glu 900 905 910 Ala Glu Glu Leu Gly Asn Arg Thr Pro Leu Leu Pro Ile Leu Gly Gln 915 920 925 Leu Glu Glu Val Ala Gly Lys Asn Ile Leu Ser Thr Leu Ala Thr Gly 930 935 940 Arg Asp Ser Thr Leu Asp Thr Ala Cys Ile Asp Gln Ser Thr Val Ala 945 950 955 960 Ile Ala Gly Met Asn Glu Thr Gln Gln Lys Ala Leu Leu Asp Met Phe 965 970 975 Phe Ser Asn Ala Asp Ile Val Pro Gly Pro Leu Met Glu Asp Asn Thr 980 985 990 Arg Leu Met Ala Val Phe Glu Thr Phe Lys Lys Arg Asp Ala Leu Arg 995 1000 1005 Glu Val Leu Gln Thr Glu Gly Leu Ile Lys Thr Ala Val Glu Leu Leu 1010 1015 1020 Arg Ala Met Arg Gly Thr Gln Arg Gln Leu Tyr Ser Ser Ala Arg Ile 1025 1030 1035 1040 Arg Phe Asp Lys Leu Asp Gly Val Asn Thr Asp Asn Pro Glu Asn Met 1045 1050 1055 Trp Ala Leu Thr Pro Val Val Ser Leu Val Phe Ala Leu Ser Ser Arg 1060 1065 1070 Leu His Ala His Glu Leu Ile Gly Lys Thr Arg Thr Leu Asp Arg Ala 1075 1080 1085 Ser Ala Gly Trp Gly Arg Ile Ala Asp Leu Val Pro Asp Leu Val Thr 1090 1095 1100 Gly Asp Leu Ile Ser Ala Glu Ala Met Val Leu Gly Ala Arg Asn Pro 1105 1110 1115 1120 Gly Leu Val Asp <210> 243 <211> 1351 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1321) <223> RXA02104 <400> 243 accttttcga tagccgtata tgccatggac ccactcctca attgggcgac cgttagactt 60 gaaacactaa ggctagagat tttaactaaa gagtctcctc atg gat tcc cat ttg 115 Met Asp Ser His Leu 1 5 gag cct tat tta cac agg cca cct ggc ttg ttt ccc acc gcg atg tgc 163 Glu Pro Tyr Leu His Arg Pro Pro Gly Leu Phe Pro Thr Ala Met Cys 10 15 20 cac aat aac gcc ata aca gaa agg cat act gac aca atg tcc aac tcc 211 His Asn Asn Ala Ile Thr Glu Arg His Thr Asp Thr Met Ser Asn Ser 25 30 35 ccc acc gac gtt tca acg agc gca cct cga att atg atc gcg cca gat 259 Pro Thr Asp Val Ser Thr Ser Ala Pro Arg Ile Met Ile Ala Pro Asp 40 45 50 tcc tac aaa gga acc gct acc gca tca gaa gct gcg caa tac tta ggc 307 Ser Tyr Lys Gly Thr Ala Thr Ala Ser Glu Ala Ala Gln Tyr Leu Gly 55 60 65 gaa ggc gtg ttg gaa att ttg ccc aac gcc tcc att acg ttg gca ccc 355 Glu Gly Val Leu Glu Ile Leu Pro Asn Ala Ser Ile Thr Leu Ala Pro 70 75 80 85 atg gcc gac ggt ggc gaa gga aca tcc tca gtt ttc ggc ggg cag gtc 403 Met Ala Asp Gly Gly Glu Gly Thr Ser Ser Val Phe Gly Gly Gln Val 90 95 100 ata aca tta ccc acg aca aat gcc gcg gga cgc ctc acc gaa gcc agc 451 Ile Thr Leu Pro Thr Thr Asn Ala Ala Gly Arg Leu Thr Glu Ala Ser 105 110 115 tac acc tta gat tcc gaa aca aac act gcc tac att gac atc gcc gca 499 Tyr Thr Leu Asp Ser Glu Thr Asn Thr Ala Tyr Ile Asp Ile Ala Ala 120 125 130 gcc tcc ggt ttg ccc gcc gtt gca gac gat cta gtc ccc acc acc ggc 547 Ala Ser Gly Leu Pro Ala Val Ala Asp Asp Leu Val Pro Thr Thr Gly 135 140 145 gat acc tac ggc acc ggc gtt ttg atc gca gac gcg gtc acc cgt ggc 595 Asp Thr Tyr Gly Thr Gly Val Leu Ile Ala Asp Ala Val Thr Arg Gly 150 155 160 165 gca act cgc att gct tta ggc ctt ggc gga tca gcc aca act gac gcc 643 Ala Thr Arg Ile Ala Leu Gly Leu Gly Gly Ser Ala Thr Thr Asp Ala 170 175 180 ggc tca gga att ctc atc gcc ctc ggc gcc gtc cca cgc aac aaa gag 691 Gly Ser Gly Ile Leu Ile Ala Leu Gly Ala Val Pro Arg Asn Lys Glu 185 190 195 ggc tac gca cta cga acc ggt ggc gcc gac ctc atc aac ctc gat tac 739 Gly Tyr Ala Leu Arg Thr Gly Gly Ala Asp Leu Ile Asn Leu Asp Tyr 200 205 210 atc gat acc gcc gaa ctc aac atc ccc gca gcc gcc gtc gaa tgg atc 787 Ile Asp Thr Ala Glu Leu Asn Ile Pro Ala Ala Ala Val Glu Trp Ile 215 220 225 ctg ctc acc gat gtc gac gcc ccc gcc acc ggc ccg cag ggc gcg gcc 835 Leu Leu Thr Asp Val Asp Ala Pro Ala Thr Gly Pro Gln Gly Ala Ala 230 235 240 245 acc gta ttc ggg ccc caa aaa ggt gcc acc gaa aaa gac att tcg ctt 883 Thr Val Phe Gly Pro Gln Lys Gly Ala Thr Glu Lys Asp Ile Ser Leu 250 255 260 ctc gac gcc gcc ctc cac cac gcc tgc gcc caa ctg gaa gtt gat ggc 931 Leu Asp Ala Ala Leu His His Ala Cys Ala Gln Leu Glu Val Asp Gly 265 270 275 aca aag cca ggt atg ggc gca gcc ggg ggc att gca atc gga ctg acg 979 Thr Lys Pro Gly Met Gly Ala Ala Gly Gly Ile Ala Ile Gly Leu Thr 280 285 290 tgg ctg tcc acc ctc atg cac ggc aac gac caa cag atc cat atc ctc 1027 Trp Leu Ser Thr Leu Met His Gly Asn Asp Gln Gln Ile His Ile Leu 295 300 305 ccc ggc gcg cca ctg att gcc cgc tcc aac gga atc gag gat gcg ctg 1075 Pro Gly Ala Pro Leu Ile Ala Arg Ser Asn Gly Ile Glu Asp Ala Leu 310 315 320 325 cca gaa act gac ttg ttg atc acc ggt gaa ggc cga cta gat tcc caa 1123 Pro Glu Thr Asp Leu Leu Ile Thr Gly Glu Gly Arg Leu Asp Ser Gln 330 335 340 tcg ttc acc gga aag gtt gtg ggc acc ctc cac ggt tta gct aaa gcc 1171 Ser Phe Thr Gly Lys Val Val Gly Thr Leu His Gly Leu Ala Lys Ala 345 350 355 cac gat gtg gat ctc gct gtt gcg gcc ggc atc gtg gaa ggc ggt att 1219 His Asp Val Asp Leu Ala Val Ala Ala Gly Ile Val Glu Gly Gly Ile 360 365 370 ccc gat gat ttc cta gcg gta gaa atg att aaa tcc tcc gac gtt gca 1267 Pro Asp Asp Phe Leu Ala Val Glu Met Ile Lys Ser Ser Asp Val Ala 375 380 385 gca caa tta cgt gat gca ggc cga agg atc gct caa gaa tac gta gct 1315 Ala Gln Leu Arg Asp Ala Gly Arg Arg Ile Ala Gln Glu Tyr Val Ala 390 395 400 405 caa aac tagcgaagga tctccacagt ccatgggtag 1351 Gln Asn <210> 244 <211> 407 <212> PRT <213> Corynebacterium glutamicum <400> 244 Met Asp Ser His Leu Glu Pro Tyr Leu His Arg Pro Pro Gly Leu Phe 1 5 10 15 Pro Thr Ala Met Cys His Asn Asn Ala Ile Thr Glu Arg His Thr Asp 20 25 30 Thr Met Ser Asn Ser Pro Thr Asp Val Ser Thr Ser Ala Pro Arg Ile 35 40 45 Met Ile Ala Pro Asp Ser Tyr Lys Gly Thr Ala Thr Ala Ser Glu Ala 50 55 60 Ala Gln Tyr Leu Gly Glu Gly Val Leu Glu Ile Leu Pro Asn Ala Ser 65 70 75 80 Ile Thr Leu Ala Pro Met Ala Asp Gly Gly Glu Gly Thr Ser Ser Val 85 90 95 Phe Gly Gly Gln Val Ile Thr Leu Pro Thr Thr Asn Ala Ala Gly Arg 100 105 110 Leu Thr Glu Ala Ser Tyr Thr Leu Asp Ser Glu Thr Asn Thr Ala Tyr 115 120 125 Ile Asp Ile Ala Ala Ala Ser Gly Leu Pro Ala Val Ala Asp Asp Leu 130 135 140 Val Pro Thr Thr Gly Asp Thr Tyr Gly Thr Gly Val Leu Ile Ala Asp 145 150 155 160 Ala Val Thr Arg Gly Ala Thr Arg Ile Ala Leu Gly Leu Gly Gly Ser 165 170 175 Ala Thr Thr Asp Ala Gly Ser Gly Ile Leu Ile Ala Leu Gly Ala Val 180 185 190 Pro Arg Asn Lys Glu Gly Tyr Ala Leu Arg Thr Gly Gly Ala Asp Leu 195 200 205 Ile Asn Leu Asp Tyr Ile Asp Thr Ala Glu Leu Asn Ile Pro Ala Ala 210 215 220 Ala Val Glu Trp Ile Leu Leu Thr Asp Val Asp Ala Pro Ala Thr Gly 225 230 235 240 Pro Gln Gly Ala Ala Thr Val Phe Gly Pro Gln Lys Gly Ala Thr Glu 245 250 255 Lys Asp Ile Ser Leu Leu Asp Ala Ala Leu His His Ala Cys Ala Gln 260 265 270 Leu Glu Val Asp Gly Thr Lys Pro Gly Met Gly Ala Ala Gly Gly Ile 275 280 285 Ala Ile Gly Leu Thr Trp Leu Ser Thr Leu Met His Gly Asn Asp Gln 290 295 300 Gln Ile His Ile Leu Pro Gly Ala Pro Leu Ile Ala Arg Ser Asn Gly 305 310 315 320 Ile Glu Asp Ala Leu Pro Glu Thr Asp Leu Leu Ile Thr Gly Glu Gly 325 330 335 Arg Leu Asp Ser Gln Ser Phe Thr Gly Lys Val Val Gly Thr Leu His 340 345 350 Gly Leu Ala Lys Ala His Asp Val Asp Leu Ala Val Ala Ala Gly Ile 355 360 365 Val Glu Gly Gly Ile Pro Asp Asp Phe Leu Ala Val Glu Met Ile Lys 370 375 380 Ser Ser Asp Val Ala Ala Gln Leu Arg Asp Ala Gly Arg Arg Ile Ala 385 390 395 400 Gln Glu Tyr Val Ala Gln Asn 405 <210> 245 <211> 1561 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1531) <223> RXA02123 <400> 245 accaggcaga acctgaccag ttgttggggt ttgcccatgc cgaatgagta aaaccacagt 60 ggattgagtc ttttcggcag ctgcgtgtga acccggcttc atg aca tgc agc ata 115 Met Thr Cys Ser Ile 1 5 cct gtg cga aaa att cct gac cgc cca ctt aaa aaa agg tct agg gtg 163 Pro Val Arg Lys Ile Pro Asp Arg Pro Leu Lys Lys Arg Ser Arg Val 10 15 20 tgg ggt gtg agt ctt cca cca aat gta caa act gtc ggt gag ctg aag 211 Trp Gly Val Ser Leu Pro Pro Asn Val Gln Thr Val Gly Glu Leu Lys 25 30 35 gcc gcc ggc cac atc tac cga cct ttg cgc gta gaa atc cgc gac aac 259 Ala Ala Gly His Ile Tyr Arg Pro Leu Arg Val Glu Ile Arg Asp Asn 40 45 50 ctc cta gcc aaa ctt cgc agc ggc gaa gat ccg tgg cca ggc ctg cac 307 Leu Leu Ala Lys Leu Arg Ser Gly Glu Asp Pro Trp Pro Gly Leu His 55 60 65 ggc ctg aac tac acg gtc atc ccg cag ctt gaa cgc gcg ctc atc gcc 355 Gly Leu Asn Tyr Thr Val Ile Pro Gln Leu Glu Arg Ala Leu Ile Ala 70 75 80 85 ggc cac gac atc gtg ctg ctc ggc gaa cgc ggc cag ggt aaa acc cgc 403 Gly His Asp Ile Val Leu Leu Gly Glu Arg Gly Gln Gly Lys Thr Arg 90 95 100 ctg ctc cgc acg tta ata acg ctt ctc gac gag tgg tcc ccg atc att 451 Leu Leu Arg Thr Leu Ile Thr Leu Leu Asp Glu Trp Ser Pro Ile Ile 105 110 115 ccc ggg cgc gac gtt cca gaa cac cct ctt gcg cca aac gta gag atc 499 Pro Gly Arg Asp Val Pro Glu His Pro Leu Ala Pro Asn Val Glu Ile 120 125 130 tcc gat gat cag ccc att gaa tgg gta cac cgc gat gcg cgc tat acc 547 Ser Asp Asp Gln Pro Ile Glu Trp Val His Arg Asp Ala Arg Tyr Thr 135 140 145 gag aaa ctt gcc acc cca gat act tcc gtg gct gat ctt atc ggt gat 595 Glu Lys Leu Ala Thr Pro Asp Thr Ser Val Ala Asp Leu Ile Gly Asp 150 155 160 165 gtt gac cca atg cgt gtt gct gaa ggc cgc agc ctc ggt gat cta gaa 643 Val Asp Pro Met Arg Val Ala Glu Gly Arg Ser Leu Gly Asp Leu Glu 170 175 180 acc att cac tac ggt ctg att cct cgc gcc aac cgt ggc atc gtg gcg 691 Thr Ile His Tyr Gly Leu Ile Pro Arg Ala Asn Arg Gly Ile Val Ala 185 190 195 atc aac gag ctt cct gac ctc gct gaa cgc atc cag gtt gcc atg ctc 739 Ile Asn Glu Leu Pro Asp Leu Ala Glu Arg Ile Gln Val Ala Met Leu 200 205 210 aac gtc atg gag gaa cgt gat gtg cag att cgt ggc tac aac att cgt 787 Asn Val Met Glu Glu Arg Asp Val Gln Ile Arg Gly Tyr Asn Ile Arg 215 220 225 ttg gac ttg gat gtg ctg gtt gtt gcc tca gcc aac cct gag gat tac 835 Leu Asp Leu Asp Val Leu Val Val Ala Ser Ala Asn Pro Glu Asp Tyr 230 235 240 245 acc aac cgt ggc cga att atc act ccg ctc aaa gac cgc ttc ggt gca 883 Thr Asn Arg Gly Arg Ile Ile Thr Pro Leu Lys Asp Arg Phe Gly Ala 250 255 260 gaa atc cgc acc cac tac cca ctt gag ttg gac gat gaa gtg gca att 931 Glu Ile Arg Thr His Tyr Pro Leu Glu Leu Asp Asp Glu Val Ala Ile 265 270 275 atc cgc cag gaa gca gag ctt gtt gcg caa gtc cct gat atc ttg gtt 979 Ile Arg Gln Glu Ala Glu Leu Val Ala Gln Val Pro Asp Ile Leu Val 280 285 290 gaa att ctt gcc cgc tac acc cga gcg ctt cgt gaa tcc tca tcg gtg 1027 Glu Ile Leu Ala Arg Tyr Thr Arg Ala Leu Arg Glu Ser Ser Ser Val 295 300 305 aat cag cgt tct ggt gtg tct gct cgt ttc tcc att gca ggt gca gaa 1075 Asn Gln Arg Ser Gly Val Ser Ala Arg Phe Ser Ile Ala Gly Ala Glu 310 315 320 325 act gtg gcc gca gca gct ctt cga cgc gca gca gtg ttc ggc gaa gat 1123 Thr Val Ala Ala Ala Ala Leu Arg Arg Ala Ala Val Phe Gly Glu Asp 330 335 340 gag gcc gtt gcc cgc ctg gtt gat ttg gaa gca gcc gtg gaa gtc ctc 1171 Glu Ala Val Ala Arg Leu Val Asp Leu Glu Ala Ala Val Glu Val Leu 345 350 355 ggc ggc aag att gaa ttt gaa tcc ggc gaa gaa gga cgc gaa tgg gaa 1219 Gly Gly Lys Ile Glu Phe Glu Ser Gly Glu Glu Gly Arg Glu Trp Glu 360 365 370 atc ctt gat tat ctc ctg cgc acc gca acc gca gaa gcg ctg cgt tcc 1267 Ile Leu Asp Tyr Leu Leu Arg Thr Ala Thr Ala Glu Ala Leu Arg Ser 375 380 385 act ctg cgc tcg ctg gat ctc acc ccg ctc atc gca gca tta gac ggc 1315 Thr Leu Arg Ser Leu Asp Leu Thr Pro Leu Ile Ala Ala Leu Asp Gly 390 395 400 405 agc atc acc gtt tcc act ggc acg aac atc acc gcg tca gaa ttt ttg 1363 Ser Ile Thr Val Ser Thr Gly Thr Asn Ile Thr Ala Ser Glu Phe Leu 410 415 420 gct tcg ctc ccc gaa ctc ggc gaa agc acg cta tat gac gac atc gct 1411 Ala Ser Leu Pro Glu Leu Gly Glu Ser Thr Leu Tyr Asp Asp Ile Ala 425 430 435 caa gct ttt ggt gcc acc aca cca agt act cgc gcg atg gcc att gag 1459 Gln Ala Phe Gly Ala Thr Thr Pro Ser Thr Arg Ala Met Ala Ile Glu 440 445 450 ctt gct ttg gaa ggt ctt tac ctt tcc cga aaa att gcc aag gat tct 1507 Leu Ala Leu Glu Gly Leu Tyr Leu Ser Arg Lys Ile Ala Lys Asp Ser 455 460 465 ggc gaa ggt gaa acc att tac ggt taactggttt taaggagcac cacagccatg 1561 Gly Glu Gly Glu Thr Ile Tyr Gly 470 475 <210> 246 <211> 477 <212> PRT <213> Corynebacterium glutamicum <400> 246 Met Thr Cys Ser Ile Pro Val Arg Lys Ile Pro Asp Arg Pro Leu Lys 1 5 10 15 Lys Arg Ser Arg Val Trp Gly Val Ser Leu Pro Pro Asn Val Gln Thr 20 25 30 Val Gly Glu Leu Lys Ala Ala Gly His Ile Tyr Arg Pro Leu Arg Val 35 40 45 Glu Ile Arg Asp Asn Leu Leu Ala Lys Leu Arg Ser Gly Glu Asp Pro 50 55 60 Trp Pro Gly Leu His Gly Leu Asn Tyr Thr Val Ile Pro Gln Leu Glu 65 70 75 80 Arg Ala Leu Ile Ala Gly His Asp Ile Val Leu Leu Gly Glu Arg Gly 85 90 95 Gln Gly Lys Thr Arg Leu Leu Arg Thr Leu Ile Thr Leu Leu Asp Glu 100 105 110 Trp Ser Pro Ile Ile Pro Gly Arg Asp Val Pro Glu His Pro Leu Ala 115 120 125 Pro Asn Val Glu Ile Ser Asp Asp Gln Pro Ile Glu Trp Val His Arg 130 135 140 Asp Ala Arg Tyr Thr Glu Lys Leu Ala Thr Pro Asp Thr Ser Val Ala 145 150 155 160 Asp Leu Ile Gly Asp Val Asp Pro Met Arg Val Ala Glu Gly Arg Ser 165 170 175 Leu Gly Asp Leu Glu Thr Ile His Tyr Gly Leu Ile Pro Arg Ala Asn 180 185 190 Arg Gly Ile Val Ala Ile Asn Glu Leu Pro Asp Leu Ala Glu Arg Ile 195 200 205 Gln Val Ala Met Leu Asn Val Met Glu Glu Arg Asp Val Gln Ile Arg 210 215 220 Gly Tyr Asn Ile Arg Leu Asp Leu Asp Val Leu Val Val Ala Ser Ala 225 230 235 240 Asn Pro Glu Asp Tyr Thr Asn Arg Gly Arg Ile Ile Thr Pro Leu Lys 245 250 255 Asp Arg Phe Gly Ala Glu Ile Arg Thr His Tyr Pro Leu Glu Leu Asp 260 265 270 Asp Glu Val Ala Ile Ile Arg Gln Glu Ala Glu Leu Val Ala Gln Val 275 280 285 Pro Asp Ile Leu Val Glu Ile Leu Ala Arg Tyr Thr Arg Ala Leu Arg 290 295 300 Glu Ser Ser Ser Val Asn Gln Arg Ser Gly Val Ser Ala Arg Phe Ser 305 310 315 320 Ile Ala Gly Ala Glu Thr Val Ala Ala Ala Ala Leu Arg Arg Ala Ala 325 330 335 Val Phe Gly Glu Asp Glu Ala Val Ala Arg Leu Val Asp Leu Glu Ala 340 345 350 Ala Val Glu Val Leu Gly Gly Lys Ile Glu Phe Glu Ser Gly Glu Glu 355 360 365 Gly Arg Glu Trp Glu Ile Leu Asp Tyr Leu Leu Arg Thr Ala Thr Ala 370 375 380 Glu Ala Leu Arg Ser Thr Leu Arg Ser Leu Asp Leu Thr Pro Leu Ile 385 390 395 400 Ala Ala Leu Asp Gly Ser Ile Thr Val Ser Thr Gly Thr Asn Ile Thr 405 410 415 Ala Ser Glu Phe Leu Ala Ser Leu Pro Glu Leu Gly Glu Ser Thr Leu 420 425 430 Tyr Asp Asp Ile Ala Gln Ala Phe Gly Ala Thr Thr Pro Ser Thr Arg 435 440 445 Ala Met Ala Ile Glu Leu Ala Leu Glu Gly Leu Tyr Leu Ser Arg Lys 450 455 460 Ile Ala Lys Asp Ser Gly Glu Gly Glu Thr Ile Tyr Gly 465 470 475 <210> 247 <211> 472 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(442) <223> RXA02138 <400> 247 tcactcgccg gagatccgta aaaaggggag tacactgcaa gcctatgatg tcccggccta 60 aaagtaattc aaagggccaa cagttaagga gactaaagcg atg acc gct cca tca 115 Met Thr Ala Pro Ser 1 5 acc aac acc ggt gtt atc ttg acc gag tcc gca gcg tcc aaa gct aag 163 Thr Asn Thr Gly Val Ile Leu Thr Glu Ser Ala Ala Ser Lys Ala Lys 10 15 20 gca ctc atc gat cag gaa ggc cgc gac gac ctc tct ctg cgt atc gcc 211 Ala Leu Ile Asp Gln Glu Gly Arg Asp Asp Leu Ser Leu Arg Ile Ala 25 30 35 gtt cag cct ggc ggc tgc tct ggc ctt cgt tac cag ctt tac ttc gac 259 Val Gln Pro Gly Gly Cys Ser Gly Leu Arg Tyr Gln Leu Tyr Phe Asp 40 45 50 gac cgc acc ctt gat ggc gat aag gaa gac atc gtc ggt ggc gtt cgc 307 Asp Arg Thr Leu Asp Gly Asp Lys Glu Asp Ile Val Gly Gly Val Arg 55 60 65 ctt gtc gtt gac aag atg agc acc cca tac ttg ctc ggc gct cag atc 355 Leu Val Val Asp Lys Met Ser Thr Pro Tyr Leu Leu Gly Ala Gln Ile 70 75 80 85 gac ttc gct gac acc atc gag cag cag ggc ttc acc atc gac aac cca 403 Asp Phe Ala Asp Thr Ile Glu Gln Gln Gly Phe Thr Ile Asp Asn Pro 90 95 100 aac gca ggc agc tct tgc gct tgt ggt gac tcc ttc aac taaagagatt 452 Asn Ala Gly Ser Ser Cys Ala Cys Gly Asp Ser Phe Asn 105 110 ccgttatgta ggaataaagg 472 <210> 248 <211> 114 <212> PRT <213> Corynebacterium glutamicum <400> 248 Met Thr Ala Pro Ser Thr Asn Thr Gly Val Ile Leu Thr Glu Ser Ala 1 5 10 15 Ala Ser Lys Ala Lys Ala Leu Ile Asp Gln Glu Gly Arg Asp Asp Leu 20 25 30 Ser Leu Arg Ile Ala Val Gln Pro Gly Gly Cys Ser Gly Leu Arg Tyr 35 40 45 Gln Leu Tyr Phe Asp Asp Arg Thr Leu Asp Gly Asp Lys Glu Asp Ile 50 55 60 Val Gly Gly Val Arg Leu Val Val Asp Lys Met Ser Thr Pro Tyr Leu 65 70 75 80 Leu Gly Ala Gln Ile Asp Phe Ala Asp Thr Ile Glu Gln Gln Gly Phe 85 90 95 Thr Ile Asp Asn Pro Asn Ala Gly Ser Ser Cys Ala Cys Gly Asp Ser 100 105 110 Phe Asn <210> 249 <211> 1381 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1351) <223> RXA02151 <400> 249 ttcaagattt aactaattgt taatcttttt ggcatacatc gagtcggacg gttgcgctgc 60 gaaatgagcg catcgtcttt tttaggagtt gtccgccacc gtg aaa act gga aac 115 Val Lys Thr Gly Asn 1 5 tta aac cca gcc cca cag cag gtg acg gct ccc cag aac aag gct cgt 163 Leu Asn Pro Ala Pro Gln Gln Val Thr Ala Pro Gln Asn Lys Ala Arg 10 15 20 atg gat tgg cca gac atc gcc aag gga ata tcc atc cta ggt gtc gtg 211 Met Asp Trp Pro Asp Ile Ala Lys Gly Ile Ser Ile Leu Gly Val Val 25 30 35 tta cta cac gtg tcg ttg gca att cca ggt ggc cag gac acc atg atg 259 Leu Leu His Val Ser Leu Ala Ile Pro Gly Gly Gln Asp Thr Met Met 40 45 50 tcc cac ctg aac gca ctg ctt gat cca ctt cgg atg cca tta ttt ttt 307 Ser His Leu Asn Ala Leu Leu Asp Pro Leu Arg Met Pro Leu Phe Phe 55 60 65 atg gtg agt gga ttt ttt gca gtt aaa gtt ctg aat caa agc ttt ggt 355 Met Val Ser Gly Phe Phe Ala Val Lys Val Leu Asn Gln Ser Phe Gly 70 75 80 85 gaa ctt ttc cgc ggg cga ctg tgg ttc tac ctg gtt cca tat ttg ctg 403 Glu Leu Phe Arg Gly Arg Leu Trp Phe Tyr Leu Val Pro Tyr Leu Leu 90 95 100 tgg act cca gtg aat ctt tat cta cac cgc ctc gag ggc aca gtt ttt 451 Trp Thr Pro Val Asn Leu Tyr Leu His Arg Leu Glu Gly Thr Val Phe 105 110 115 acc ggt aga gca ccg gga aca tgg gaa tgg tac agc ggc tcg atg ctc 499 Thr Gly Arg Ala Pro Gly Thr Trp Glu Trp Tyr Ser Gly Ser Met Leu 120 125 130 tcg gcc acc aat atg tac tgg ttc ctc tac ttc ttg gtc atc ttc aac 547 Ser Ala Thr Asn Met Tyr Trp Phe Leu Tyr Phe Leu Val Ile Phe Asn 135 140 145 cta ttt tta tgg gca acg aga aaa ctc cca gct tgg gca att gtg gcg 595 Leu Phe Leu Trp Ala Thr Arg Lys Leu Pro Ala Trp Ala Ile Val Ala 150 155 160 165 ttg gtg gcc tca ctg tgg cta ctt atg ccg gct tat agc gag att gag 643 Leu Val Ala Ser Leu Trp Leu Leu Met Pro Ala Tyr Ser Glu Ile Glu 170 175 180 att cta cgc aag tcc att att tac ttg cct aca ttc ctc att ggc gct 691 Ile Leu Arg Lys Ser Ile Ile Tyr Leu Pro Thr Phe Leu Ile Gly Ala 185 190 195 tac ttc cgc cca ctg att tcg cgt ttt gca gaa gcc gca aca agg cca 739 Tyr Phe Arg Pro Leu Ile Ser Arg Phe Ala Glu Ala Ala Thr Arg Pro 200 205 210 aaa gca ata gtg ttt gca gcg gtc ctt tat gtc tcg gga ctt gct ttg 787 Lys Ala Ile Val Phe Ala Ala Val Leu Tyr Val Ser Gly Leu Ala Leu 215 220 225 ggc gtg atc tca aat ggg ctg cgc gac agc gaa aac cat ggc gca agc 835 Gly Val Ile Ser Asn Gly Leu Arg Asp Ser Glu Asn His Gly Ala Ser 230 235 240 245 gtg ctg tgg ctg atg aac ctc cgc gat act ttt gct cat gca ctc ggc 883 Val Leu Trp Leu Met Asn Leu Arg Asp Thr Phe Ala His Ala Leu Gly 250 255 260 ggc aac ctc act gga ttc gat atg gat cac ctt cct gga atg atc att 931 Gly Asn Leu Thr Gly Phe Asp Met Asp His Leu Pro Gly Met Ile Ile 265 270 275 cgg att gtt tcc ctg cct gca gga att gtg ttg tgc gta tgg ctt ggc 979 Arg Ile Val Ser Leu Pro Ala Gly Ile Val Leu Cys Val Trp Leu Gly 280 285 290 cga ata aag cca gta ggg gag ttt ttg aaa ctt att ggt agg cac acc 1027 Arg Ile Lys Pro Val Gly Glu Phe Leu Lys Leu Ile Gly Arg His Thr 295 300 305 ctt ccc atc tac att ggg cat gca aca gga cta tcg ctg att ttt ggt 1075 Leu Pro Ile Tyr Ile Gly His Ala Thr Gly Leu Ser Leu Ile Phe Gly 310 315 320 325 ttc ggc ttg cgc tgg aat ttc atg gag att gat aac ttc tct gac agt 1123 Phe Gly Leu Arg Trp Asn Phe Met Glu Ile Asp Asn Phe Ser Asp Ser 330 335 340 ttg tgg cac cac acc aat acg tgg atg gtc atc gcg ttt gcc tgc gcg 1171 Leu Trp His His Thr Asn Thr Trp Met Val Ile Ala Phe Ala Cys Ala 345 350 355 atg ctc ggc ggg tac ctg acc tat ctg atc tcg cga gtt cca gtg ctg 1219 Met Leu Gly Gly Tyr Leu Thr Tyr Leu Ile Ser Arg Val Pro Val Leu 360 365 370 gga tgg act ctt gtt ccc cct aaa ctg cca gaa cca gat aaa act cca 1267 Gly Trp Thr Leu Val Pro Pro Lys Leu Pro Glu Pro Asp Lys Thr Pro 375 380 385 gct aaa gca caa gct gat tct cac gtt aaa gct cag tct gcg aag cct 1315 Ala Lys Ala Gln Ala Asp Ser His Val Lys Ala Gln Ser Ala Lys Pro 390 395 400 405 atg aat gct tct acc tct tct aag acg tac ggt ata taactgaagc 1361 Met Asn Ala Ser Thr Ser Ser Lys Thr Tyr Gly Ile 410 415 ataacctgtg tgattctgct 1381 <210> 250 <211> 417 <212> PRT <213> Corynebacterium glutamicum <400> 250 Val Lys Thr Gly Asn Leu Asn Pro Ala Pro Gln Gln Val Thr Ala Pro 1 5 10 15 Gln Asn Lys Ala Arg Met Asp Trp Pro Asp Ile Ala Lys Gly Ile Ser 20 25 30 Ile Leu Gly Val Val Leu Leu His Val Ser Leu Ala Ile Pro Gly Gly 35 40 45 Gln Asp Thr Met Met Ser His Leu Asn Ala Leu Leu Asp Pro Leu Arg 50 55 60 Met Pro Leu Phe Phe Met Val Ser Gly Phe Phe Ala Val Lys Val Leu 65 70 75 80 Asn Gln Ser Phe Gly Glu Leu Phe Arg Gly Arg Leu Trp Phe Tyr Leu 85 90 95 Val Pro Tyr Leu Leu Trp Thr Pro Val Asn Leu Tyr Leu His Arg Leu 100 105 110 Glu Gly Thr Val Phe Thr Gly Arg Ala Pro Gly Thr Trp Glu Trp Tyr 115 120 125 Ser Gly Ser Met Leu Ser Ala Thr Asn Met Tyr Trp Phe Leu Tyr Phe 130 135 140 Leu Val Ile Phe Asn Leu Phe Leu Trp Ala Thr Arg Lys Leu Pro Ala 145 150 155 160 Trp Ala Ile Val Ala Leu Val Ala Ser Leu Trp Leu Leu Met Pro Ala 165 170 175 Tyr Ser Glu Ile Glu Ile Leu Arg Lys Ser Ile Ile Tyr Leu Pro Thr 180 185 190 Phe Leu Ile Gly Ala Tyr Phe Arg Pro Leu Ile Ser Arg Phe Ala Glu 195 200 205 Ala Ala Thr Arg Pro Lys Ala Ile Val Phe Ala Ala Val Leu Tyr Val 210 215 220 Ser Gly Leu Ala Leu Gly Val Ile Ser Asn Gly Leu Arg Asp Ser Glu 225 230 235 240 Asn His Gly Ala Ser Val Leu Trp Leu Met Asn Leu Arg Asp Thr Phe 245 250 255 Ala His Ala Leu Gly Gly Asn Leu Thr Gly Phe Asp Met Asp His Leu 260 265 270 Pro Gly Met Ile Ile Arg Ile Val Ser Leu Pro Ala Gly Ile Val Leu 275 280 285 Cys Val Trp Leu Gly Arg Ile Lys Pro Val Gly Glu Phe Leu Lys Leu 290 295 300 Ile Gly Arg His Thr Leu Pro Ile Tyr Ile Gly His Ala Thr Gly Leu 305 310 315 320 Ser Leu Ile Phe Gly Phe Gly Leu Arg Trp Asn Phe Met Glu Ile Asp 325 330 335 Asn Phe Ser Asp Ser Leu Trp His His Thr Asn Thr Trp Met Val Ile 340 345 350 Ala Phe Ala Cys Ala Met Leu Gly Gly Tyr Leu Thr Tyr Leu Ile Ser 355 360 365 Arg Val Pro Val Leu Gly Trp Thr Leu Val Pro Pro Lys Leu Pro Glu 370 375 380 Pro Asp Lys Thr Pro Ala Lys Ala Gln Ala Asp Ser His Val Lys Ala 385 390 395 400 Gln Ser Ala Lys Pro Met Asn Ala Ser Thr Ser Ser Lys Thr Tyr Gly 405 410 415 Ile <210> 251 <211> 1027 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(997) <223> RXA02163 <400> 251 cttgaccgag gtcagagcag taattggctc ggaaaagaag gaattcttcg aagatccaga 60 agtcgttgaa gccttcgccg accacggctt tgaagttaac gtg gac acc gca gga 115 Val Asp Thr Ala Gly 1 5 tct cgt cgg atc gcc act gat gtg gac ttg agc ccg tac gat ttc gcg 163 Ser Arg Arg Ile Ala Thr Asp Val Asp Leu Ser Pro Tyr Asp Phe Ala 10 15 20 ttc cca tcc tct gca cca gct gcg cag aag atc tcc gaa gcc aac acc 211 Phe Pro Ser Ser Ala Pro Ala Ala Gln Lys Ile Ser Glu Ala Asn Thr 25 30 35 acg acg ggc cga ttc acc cca ttc tat tcg cct atg gcg gta gca aca 259 Thr Thr Gly Arg Phe Thr Pro Phe Tyr Ser Pro Met Ala Val Ala Thr 40 45 50 ttc gga acc atc acc gac atg ttg gaa acc aag ggg atc gtg agc aat 307 Phe Gly Thr Ile Thr Asp Met Leu Glu Thr Lys Gly Ile Val Ser Asn 55 60 65 gta ggc ggc acc gac acc atc gat ttg ggc gcg ttg ttg aat gaa acc 355 Val Gly Gly Thr Asp Thr Ile Asp Leu Gly Ala Leu Leu Asn Glu Thr 70 75 80 85 caa gcc gga acc cgc tgg agc gaa ctt agc ccc aac tat cag tcc aac 403 Gln Ala Gly Thr Arg Trp Ser Glu Leu Ser Pro Asn Tyr Gln Ser Asn 90 95 100 cgc gtc gtg cag att tct acc acc gat gtg cgc acc tct aac tcg gcg 451 Arg Val Val Gln Ile Ser Thr Thr Asp Val Arg Thr Ser Asn Ser Ala 105 110 115 gcc atg tac cta tca atg atg tcc tgg gtg aaa aat ggc gga aaa acg 499 Ala Met Tyr Leu Ser Met Met Ser Trp Val Lys Asn Gly Gly Lys Thr 120 125 130 gtg agc agc act gcg gaa gcc gat gcc atc atc cca gag ctt agc caa 547 Val Ser Ser Thr Ala Glu Ala Asp Ala Ile Ile Pro Glu Leu Ser Gln 135 140 145 ctg ttc gtg ggc cag ggc tat acc gaa agc acc tcc gcc ggc ccg ttt 595 Leu Phe Val Gly Gln Gly Tyr Thr Glu Ser Thr Ser Ala Gly Pro Phe 150 155 160 165 gat gaa tac ctc tcc caa gga atg ggt tct aaa cca atg gtg atg atc 643 Asp Glu Tyr Leu Ser Gln Gly Met Gly Ser Lys Pro Met Val Met Ile 170 175 180 tac gaa gcc cag ttc ctc gcg gaa caa aac aag gaa aac tca cgg att 691 Tyr Glu Ala Gln Phe Leu Ala Glu Gln Asn Lys Glu Asn Ser Arg Ile 185 190 195 tcc ggc gat atg gaa cta gtg tat cca agc ccc acc gtg tac agc acg 739 Ser Gly Asp Met Glu Leu Val Tyr Pro Ser Pro Thr Val Tyr Ser Thr 200 205 210 cat acg gtg gtt agc ttg agt gac gtc ggc gcg gag atc ggc gaa ctc 787 His Thr Val Val Ser Leu Ser Asp Val Gly Ala Glu Ile Gly Glu Leu 215 220 225 cta gaa acc gac gaa acc ctg cag cag ttg gca gtc aaa cac ggt ttt 835 Leu Glu Thr Asp Glu Thr Leu Gln Gln Leu Ala Val Lys His Gly Phe 230 235 240 245 agg cca aag aac tcc gca atg atc gcc gat gct ggc atg acc gac cgc 883 Arg Pro Lys Asn Ser Ala Met Ile Ala Asp Ala Gly Met Thr Asp Arg 250 255 260 atg ccc aac aac ctc aat gtc att gat ccg ccg gac tat gac ttc cta 931 Met Pro Asn Asn Leu Asn Val Ile Asp Pro Pro Asp Tyr Asp Phe Leu 265 270 275 gaa cga ctc att gat ggc gtg ggc gca tcg tac agt gcc acc cca gca 979 Glu Arg Leu Ile Asp Gly Val Gly Ala Ser Tyr Ser Ala Thr Pro Ala 280 285 290 gaa gag gac aca gat cta tgaaaaatct tgtaaaaggt acagcgctgg 1027 Glu Glu Asp Thr Asp Leu 295 <210> 252 <211> 299 <212> PRT <213> Corynebacterium glutamicum <400> 252 Val Asp Thr Ala Gly Ser Arg Arg Ile Ala Thr Asp Val Asp Leu Ser 1 5 10 15 Pro Tyr Asp Phe Ala Phe Pro Ser Ser Ala Pro Ala Ala Gln Lys Ile 20 25 30 Ser Glu Ala Asn Thr Thr Thr Gly Arg Phe Thr Pro Phe Tyr Ser Pro 35 40 45 Met Ala Val Ala Thr Phe Gly Thr Ile Thr Asp Met Leu Glu Thr Lys 50 55 60 Gly Ile Val Ser Asn Val Gly Gly Thr Asp Thr Ile Asp Leu Gly Ala 65 70 75 80 Leu Leu Asn Glu Thr Gln Ala Gly Thr Arg Trp Ser Glu Leu Ser Pro 85 90 95 Asn Tyr Gln Ser Asn Arg Val Val Gln Ile Ser Thr Thr Asp Val Arg 100 105 110 Thr Ser Asn Ser Ala Ala Met Tyr Leu Ser Met Met Ser Trp Val Lys 115 120 125 Asn Gly Gly Lys Thr Val Ser Ser Thr Ala Glu Ala Asp Ala Ile Ile 130 135 140 Pro Glu Leu Ser Gln Leu Phe Val Gly Gln Gly Tyr Thr Glu Ser Thr 145 150 155 160 Ser Ala Gly Pro Phe Asp Glu Tyr Leu Ser Gln Gly Met Gly Ser Lys 165 170 175 Pro Met Val Met Ile Tyr Glu Ala Gln Phe Leu Ala Glu Gln Asn Lys 180 185 190 Glu Asn Ser Arg Ile Ser Gly Asp Met Glu Leu Val Tyr Pro Ser Pro 195 200 205 Thr Val Tyr Ser Thr His Thr Val Val Ser Leu Ser Asp Val Gly Ala 210 215 220 Glu Ile Gly Glu Leu Leu Glu Thr Asp Glu Thr Leu Gln Gln Leu Ala 225 230 235 240 Val Lys His Gly Phe Arg Pro Lys Asn Ser Ala Met Ile Ala Asp Ala 245 250 255 Gly Met Thr Asp Arg Met Pro Asn Asn Leu Asn Val Ile Asp Pro Pro 260 265 270 Asp Tyr Asp Phe Leu Glu Arg Leu Ile Asp Gly Val Gly Ala Ser Tyr 275 280 285 Ser Ala Thr Pro Ala Glu Glu Asp Thr Asp Leu 290 295 <210> 253 <211> 709 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(679) <223> RXA02185 <400> 253 caactccttg gggtgaagcc agacatccac tggcagagca actcctccgc tctaacccga 60 cagctaacct cgacggcgac aaatgagagg aaaacttttc atg gga cgt cac tcc 115 Met Gly Arg His Ser 1 5 act aag act agc tcc gcg ttc acc aag ctc gca gct tcc acc atc gct 163 Thr Lys Thr Ser Ser Ala Phe Thr Lys Leu Ala Ala Ser Thr Ile Ala 10 15 20 ttc ggt gct gct gca acc atc atg gct cct tct gca tct gct gca cct 211 Phe Gly Ala Ala Ala Thr Ile Met Ala Pro Ser Ala Ser Ala Ala Pro 25 30 35 gat tcc gac tgg gat cgc ctc gca cag tgc gag tcc ggt ggt aac tgg 259 Asp Ser Asp Trp Asp Arg Leu Ala Gln Cys Glu Ser Gly Gly Asn Trp 40 45 50 gca atc aac acc ggt aac ggc tac cac ggt ggt ctg cag ttc tcc gct 307 Ala Ile Asn Thr Gly Asn Gly Tyr His Gly Gly Leu Gln Phe Ser Ala 55 60 65 agc acc tgg gct gct tac ggc ggc cag gag ttc gct acc tac gca tac 355 Ser Thr Trp Ala Ala Tyr Gly Gly Gln Glu Phe Ala Thr Tyr Ala Tyr 70 75 80 85 cag gca acc cgt gag cag cag atc gct gtt gca gag cgc acc ttg gct 403 Gln Ala Thr Arg Glu Gln Gln Ile Ala Val Ala Glu Arg Thr Leu Ala 90 95 100 ggt cag ggc tgg ggc gca tgg cct gct tgc tcc gct tcc ctt gga ctg 451 Gly Gln Gly Trp Gly Ala Trp Pro Ala Cys Ser Ala Ser Leu Gly Leu 105 110 115 aac tcc gct cca acc cag cgt gac ctc tcc gct acc acc tcc acc cca 499 Asn Ser Ala Pro Thr Gln Arg Asp Leu Ser Ala Thr Thr Ser Thr Pro 120 125 130 gag cca gct gca gct gca cca gct gtt gct gag tac aac gct cct gca 547 Glu Pro Ala Ala Ala Ala Pro Ala Val Ala Glu Tyr Asn Ala Pro Ala 135 140 145 gcc aac atc gca gtt ggc tcc acc gac ttg aac acc atc aag tcc acc 595 Ala Asn Ile Ala Val Gly Ser Thr Asp Leu Asn Thr Ile Lys Ser Thr 150 155 160 165 tac ggc gct gtc acc ggc acc ctc gct cag tac ggc atc acc gtt cca 643 Tyr Gly Ala Val Thr Gly Thr Leu Ala Gln Tyr Gly Ile Thr Val Pro 170 175 180 gct gag gtt gag tct tac tac aac gct ttc gtc ggc taaatctagc 689 Ala Glu Val Glu Ser Tyr Tyr Asn Ala Phe Val Gly 185 190 tgcacttttt aaaagggagg 709 <210> 254 <211> 193 <212> PRT <213> Corynebacterium glutamicum <400> 254 Met Gly Arg His Ser Thr Lys Thr Ser Ser Ala Phe Thr Lys Leu Ala 1 5 10 15 Ala Ser Thr Ile Ala Phe Gly Ala Ala Ala Thr Ile Met Ala Pro Ser 20 25 30 Ala Ser Ala Ala Pro Asp Ser Asp Trp Asp Arg Leu Ala Gln Cys Glu 35 40 45 Ser Gly Gly Asn Trp Ala Ile Asn Thr Gly Asn Gly Tyr His Gly Gly 50 55 60 Leu Gln Phe Ser Ala Ser Thr Trp Ala Ala Tyr Gly Gly Gln Glu Phe 65 70 75 80 Ala Thr Tyr Ala Tyr Gln Ala Thr Arg Glu Gln Gln Ile Ala Val Ala 85 90 95 Glu Arg Thr Leu Ala Gly Gln Gly Trp Gly Ala Trp Pro Ala Cys Ser 100 105 110 Ala Ser Leu Gly Leu Asn Ser Ala Pro Thr Gln Arg Asp Leu Ser Ala 115 120 125 Thr Thr Ser Thr Pro Glu Pro Ala Ala Ala Ala Pro Ala Val Ala Glu 130 135 140 Tyr Asn Ala Pro Ala Ala Asn Ile Ala Val Gly Ser Thr Asp Leu Asn 145 150 155 160 Thr Ile Lys Ser Thr Tyr Gly Ala Val Thr Gly Thr Leu Ala Gln Tyr 165 170 175 Gly Ile Thr Val Pro Ala Glu Val Glu Ser Tyr Tyr Asn Ala Phe Val 180 185 190 Gly <210> 255 <211> 328 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(298) <223> RXA02186 <400> 255 tccaaccacc ccttgagggt ggggatgggg gagtcttttt tcatgatgtt gttaagttta 60 agccttgttg aggtgacttt tgttcccaga gtttgaaaga atg tat gac atg gca 115 Met Tyr Asp Met Ala 1 5 aac gta gag aag aag cac ttc gtc gat ccg gca tgg ccg gag cac aat 163 Asn Val Glu Lys Lys His Phe Val Asp Pro Ala Trp Pro Glu His Asn 10 15 20 cca gct gac gga cac gtc gtt act gaa ctc atc tcc aag gtc gca ggc 211 Pro Ala Asp Gly His Val Val Thr Glu Leu Ile Ser Lys Val Ala Gly 25 30 35 gcg tcc agc cca tgg ggc gat gac aag gaa ttc cca gtt tct gca gaa 259 Ala Ser Ser Pro Trp Gly Asp Asp Lys Glu Phe Pro Val Ser Ala Glu 40 45 50 gag acc gga tac gtt cac ccg tac acc cgg atc aac cgc taagaaactt 308 Glu Thr Gly Tyr Val His Pro Tyr Thr Arg Ile Asn Arg 55 60 65 aaaaaagagg caacccgttt 328 <210> 256 <211> 66 <212> PRT <213> Corynebacterium glutamicum <400> 256 Met Tyr Asp Met Ala Asn Val Glu Lys Lys His Phe Val Asp Pro Ala 1 5 10 15 Trp Pro Glu His Asn Pro Ala Asp Gly His Val Val Thr Glu Leu Ile 20 25 30 Ser Lys Val Ala Gly Ala Ser Ser Pro Trp Gly Asp Asp Lys Glu Phe 35 40 45 Pro Val Ser Ala Glu Glu Thr Gly Tyr Val His Pro Tyr Thr Arg Ile 50 55 60 Asn Arg 65 <210> 257 <211> 508 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(478) <223> RXA02203 <400> 257 cgattcaaaa gagttcaccg aggtaggaaa catcgtggtc gcagccattg atgccctcct 60 gggcgtgcag ctctaggaaa tttcaggaac aatacatctc atg acc att cgc gcc 115 Met Thr Ile Arg Ala 1 5 act ttc cag cct tcc gta gat gaa ttc atc tcc act ctc gaa gag ttt 163 Thr Phe Gln Pro Ser Val Asp Glu Phe Ile Ser Thr Leu Glu Glu Phe 10 15 20 gca aca ggt tca tac ctt aaa gag gac gaa aag gaa ttc tgg gac gaa 211 Ala Thr Gly Ser Tyr Leu Lys Glu Asp Glu Lys Glu Phe Trp Asp Glu 25 30 35 cct ttc gat gtc aag gca ctt cca gat ctt cgt ttc atc ttg gaa aac 259 Pro Phe Asp Val Lys Ala Leu Pro Asp Leu Arg Phe Ile Leu Glu Asn 40 45 50 tac ctt gat tcc cta gat aag ctc ggt gaa gca cca gac ctt gat gct 307 Tyr Leu Asp Ser Leu Asp Lys Leu Gly Glu Ala Pro Asp Leu Asp Ala 55 60 65 gtt aac gcc tcc gct cag tcc acc ctt gat gag ctg gag aag ttc aac 355 Val Asn Ala Ser Ala Gln Ser Thr Leu Asp Glu Leu Glu Lys Phe Asn 70 75 80 85 aca aag cac cac ggt gct gtt gtt gag cct gaa gaa aaa gaa gag atc 403 Thr Lys His His Gly Ala Val Val Glu Pro Glu Glu Lys Glu Glu Ile 90 95 100 act aaa ttg atg ttt gat gct gca aag cag act ggt gca gat gat ctt 451 Thr Lys Leu Met Phe Asp Ala Ala Lys Gln Thr Gly Ala Asp Asp Leu 105 110 115 tct gca gag gct ttc cct gag ttt gag taaatttcag tagaagtttt 498 Ser Ala Glu Ala Phe Pro Glu Phe Glu 120 125 ttagcgccat 508 <210> 258 <211> 126 <212> PRT <213> Corynebacterium glutamicum <400> 258 Met Thr Ile Arg Ala Thr Phe Gln Pro Ser Val Asp Glu Phe Ile Ser 1 5 10 15 Thr Leu Glu Glu Phe Ala Thr Gly Ser Tyr Leu Lys Glu Asp Glu Lys 20 25 30 Glu Phe Trp Asp Glu Pro Phe Asp Val Lys Ala Leu Pro Asp Leu Arg 35 40 45 Phe Ile Leu Glu Asn Tyr Leu Asp Ser Leu Asp Lys Leu Gly Glu Ala 50 55 60 Pro Asp Leu Asp Ala Val Asn Ala Ser Ala Gln Ser Thr Leu Asp Glu 65 70 75 80 Leu Glu Lys Phe Asn Thr Lys His His Gly Ala Val Val Glu Pro Glu 85 90 95 Glu Lys Glu Glu Ile Thr Lys Leu Met Phe Asp Ala Ala Lys Gln Thr 100 105 110 Gly Ala Asp Asp Leu Ser Ala Glu Ala Phe Pro Glu Phe Glu 115 120 125 <210> 259 <211> 1198 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1168) <223> RXA02206 <400> 259 gccggcatcg gcaccccaga acagctcaga gatgattcgg aggtgtccgc tggagctgat 60 cggcaggaac tctgtgaggc cttgaacgat ggagagcaca atg gtt tgt acc cag 115 Met Val Cys Thr Gln 1 5 cca ata ttt tca gtt gcg gca gga tct gct gct gcg gct agg agg gtt 163 Pro Ile Phe Ser Val Ala Ala Gly Ser Ala Ala Ala Ala Arg Arg Val 10 15 20 atc tct tca ttc acc cga tct acc gta cta cct tat gac ctc agt agt 211 Ile Ser Ser Phe Thr Arg Ser Thr Val Leu Pro Tyr Asp Leu Ser Ser 25 30 35 gtg gtg ggc gtg aaa cag cga atg gtc ggt tca agt ggt ttg cgg gta 259 Val Val Gly Val Lys Gln Arg Met Val Gly Ser Ser Gly Leu Arg Val 40 45 50 tcc agg ctc ggt ttg ggc acc tca aca tgg ggc tcg ggc acc gag ctg 307 Ser Arg Leu Gly Leu Gly Thr Ser Thr Trp Gly Ser Gly Thr Glu Leu 55 60 65 gct gag gca ggc gat atc ttt aag gcg ttc atc aat tct ggt ggc acg 355 Ala Glu Ala Gly Asp Ile Phe Lys Ala Phe Ile Asn Ser Gly Gly Thr 70 75 80 85 ctt atc gac gtc tcc ccc aac tac acc acc ggc gtc gcg gaa gaa atg 403 Leu Ile Asp Val Ser Pro Asn Tyr Thr Thr Gly Val Ala Glu Glu Met 90 95 100 ctc ggc acg atg ttg gat gcg gaa gtc tct cgt tcg gct gtc gtc att 451 Leu Gly Thr Met Leu Asp Ala Glu Val Ser Arg Ser Ala Val Val Ile 105 110 115 tcc tcc agc gca ggt gtc aac ccc gct ctg ccg ctc ggc cga cgt gtg 499 Ser Ser Ser Ala Gly Val Asn Pro Ala Leu Pro Leu Gly Arg Arg Val 120 125 130 gat tgc tcc cgc cgc aat ttg att gcc caa tta gat gtc acc ctg cgg 547 Asp Cys Ser Arg Arg Asn Leu Ile Ala Gln Leu Asp Val Thr Leu Arg 135 140 145 gca tta aac act gac tat ttg gat ttg tgg tct gtg ggc tat tgg gat 595 Ala Leu Asn Thr Asp Tyr Leu Asp Leu Trp Ser Val Gly Tyr Trp Asp 150 155 160 165 gag ggc acc cca ccg cat gag gtg gcc gat act ttg gat tac gcc gtg 643 Glu Gly Thr Pro Pro His Glu Val Ala Asp Thr Leu Asp Tyr Ala Val 170 175 180 cgc acc ggc cga gtc cga tat gcc ggt gtc cga gga tat tcc ggt tgg 691 Arg Thr Gly Arg Val Arg Tyr Ala Gly Val Arg Gly Tyr Ser Gly Trp 185 190 195 cag tta gcg gtc acc cac gct gca tcc aat cat gca gcg gcc tcc gcc 739 Gln Leu Ala Val Thr His Ala Ala Ser Asn His Ala Ala Ala Ser Ala 200 205 210 cgc ccc gtg gtc gtt gca caa aat gaa tac agc ctg ctg gaa cgc cgc 787 Arg Pro Val Val Val Ala Gln Asn Glu Tyr Ser Leu Leu Glu Arg Arg 215 220 225 gca gaa caa gaa ctc ctc cct gcc acc caa cac cta ggt gtc gga ttc 835 Ala Glu Gln Glu Leu Leu Pro Ala Thr Gln His Leu Gly Val Gly Phe 230 235 240 245 ttt gct ggc gct ccg ctg ggg caa ggc gtg ctg act gct aaa tac cgc 883 Phe Ala Gly Ala Pro Leu Gly Gln Gly Val Leu Thr Ala Lys Tyr Arg 250 255 260 tcc gaa att ccc cat gat tcc aga gct gca tcc aca gga cgc gac gca 931 Ser Glu Ile Pro His Asp Ser Arg Ala Ala Ser Thr Gly Arg Asp Ala 265 270 275 gaa gtc caa agc tac cta gat aat cga ggc cgc atc att gtc gat gct 979 Glu Val Gln Ser Tyr Leu Asp Asn Arg Gly Arg Ile Ile Val Asp Ala 280 285 290 ctt gat act gca gcc aaa gga tta ggc att agc ccc gct gtc aca gcc 1027 Leu Asp Thr Ala Ala Lys Gly Leu Gly Ile Ser Pro Ala Val Thr Ala 295 300 305 acc acc tgg gtg cgt gat cgt ccc gga gtg aca gct gtc atc gtg ggc 1075 Thr Thr Trp Val Arg Asp Arg Pro Gly Val Thr Ala Val Ile Val Gly 310 315 320 325 gct cgc aca cat gaa cag ctg tca cat ctt ctc aag gcg gaa tcg gtg 1123 Ala Arg Thr His Glu Gln Leu Ser His Leu Leu Lys Ala Glu Ser Val 330 335 340 act ttg cca aca cca atc aca caa gcc ctt gat gat gtc tcc ctg 1168 Thr Leu Pro Thr Pro Ile Thr Gln Ala Leu Asp Asp Val Ser Leu 345 350 355 tgacttggtc caattacatt cactggtaat 1198 <210> 260 <211> 356 <212> PRT <213> Corynebacterium glutamicum <400> 260 Met Val Cys Thr Gln Pro Ile Phe Ser Val Ala Ala Gly Ser Ala Ala 1 5 10 15 Ala Ala Arg Arg Val Ile Ser Ser Phe Thr Arg Ser Thr Val Leu Pro 20 25 30 Tyr Asp Leu Ser Ser Val Val Gly Val Lys Gln Arg Met Val Gly Ser 35 40 45 Ser Gly Leu Arg Val Ser Arg Leu Gly Leu Gly Thr Ser Thr Trp Gly 50 55 60 Ser Gly Thr Glu Leu Ala Glu Ala Gly Asp Ile Phe Lys Ala Phe Ile 65 70 75 80 Asn Ser Gly Gly Thr Leu Ile Asp Val Ser Pro Asn Tyr Thr Thr Gly 85 90 95 Val Ala Glu Glu Met Leu Gly Thr Met Leu Asp Ala Glu Val Ser Arg 100 105 110 Ser Ala Val Val Ile Ser Ser Ser Ala Gly Val Asn Pro Ala Leu Pro 115 120 125 Leu Gly Arg Arg Val Asp Cys Ser Arg Arg Asn Leu Ile Ala Gln Leu 130 135 140 Asp Val Thr Leu Arg Ala Leu Asn Thr Asp Tyr Leu Asp Leu Trp Ser 145 150 155 160 Val Gly Tyr Trp Asp Glu Gly Thr Pro Pro His Glu Val Ala Asp Thr 165 170 175 Leu Asp Tyr Ala Val Arg Thr Gly Arg Val Arg Tyr Ala Gly Val Arg 180 185 190 Gly Tyr Ser Gly Trp Gln Leu Ala Val Thr His Ala Ala Ser Asn His 195 200 205 Ala Ala Ala Ser Ala Arg Pro Val Val Val Ala Gln Asn Glu Tyr Ser 210 215 220 Leu Leu Glu Arg Arg Ala Glu Gln Glu Leu Leu Pro Ala Thr Gln His 225 230 235 240 Leu Gly Val Gly Phe Phe Ala Gly Ala Pro Leu Gly Gln Gly Val Leu 245 250 255 Thr Ala Lys Tyr Arg Ser Glu Ile Pro His Asp Ser Arg Ala Ala Ser 260 265 270 Thr Gly Arg Asp Ala Glu Val Gln Ser Tyr Leu Asp Asn Arg Gly Arg 275 280 285 Ile Ile Val Asp Ala Leu Asp Thr Ala Ala Lys Gly Leu Gly Ile Ser 290 295 300 Pro Ala Val Thr Ala Thr Thr Trp Val Arg Asp Arg Pro Gly Val Thr 305 310 315 320 Ala Val Ile Val Gly Ala Arg Thr His Glu Gln Leu Ser His Leu Leu 325 330 335 Lys Ala Glu Ser Val Thr Leu Pro Thr Pro Ile Thr Gln Ala Leu Asp 340 345 350 Asp Val Ser Leu 355 <210> 261 <211> 802 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(772) <223> RXA02217 <400> 261 tccgcggccc caaatgggta tgggcgcttt tgaccatcgt caatggtgtt ggccccgctg 60 cctactgggc tttcggcagg aaaaactaag agttgttagg gtg gcg ctc atg act 115 Val Ala Leu Met Thr 1 5 aat aaa aca cga gct cta ctc att ggt ggc cac ggc aag gtg gcc ctc 163 Asn Lys Thr Arg Ala Leu Leu Ile Gly Gly His Gly Lys Val Ala Leu 10 15 20 cta gca acc ccc atg ctt atc gac gcc tcg gtg cag gtc act tcc atg 211 Leu Ala Thr Pro Met Leu Ile Asp Ala Ser Val Gln Val Thr Ser Met 25 30 35 tac cgc aat ccg gac cac agg tcc gaa att gag gcg ctg ggc gcc aca 259 Tyr Arg Asn Pro Asp His Arg Ser Glu Ile Glu Ala Leu Gly Ala Thr 40 45 50 act tta gag cgt gac gtc acc aca ctc agc gtg gag gat tgg gca gat 307 Thr Leu Glu Arg Asp Val Thr Thr Leu Ser Val Glu Asp Trp Ala Asp 55 60 65 ctg ctc aag gac ttc gac gta gtg gtg tgg agc gcc gga aac ggt ggc 355 Leu Leu Lys Asp Phe Asp Val Val Val Trp Ser Ala Gly Asn Gly Gly 70 75 80 85 aag aac ggc gcg gat gca act tat gcc att gat cgt gat gcc gcg atc 403 Lys Asn Gly Ala Asp Ala Thr Tyr Ala Ile Asp Arg Asp Ala Ala Ile 90 95 100 gca tcc att gat ggt gca gct agc cta ggg gag aag gca cct cgc tac 451 Ala Ser Ile Asp Gly Ala Ala Ser Leu Gly Glu Lys Ala Pro Arg Tyr 105 110 115 atc atg gtg agc tac att gga tcc tcc acg cac acc att gat cct tca 499 Ile Met Val Ser Tyr Ile Gly Ser Ser Thr His Thr Ile Asp Pro Ser 120 125 130 gca tcc ttc tac cca tat gca gaa tcc aaa aag gcc gct gat gag cac 547 Ala Ser Phe Tyr Pro Tyr Ala Glu Ser Lys Lys Ala Ala Asp Glu His 135 140 145 cta agc tcc acc aac ctg gat tac ctt atc ctc gca cca gca gcc tta 595 Leu Ser Ser Thr Asn Leu Asp Tyr Leu Ile Leu Ala Pro Ala Ala Leu 150 155 160 165 act ctg gat gaa gtc aat ggc gtt gag gtg atc gcc gat acc tac gaa 643 Thr Leu Asp Glu Val Asn Gly Val Glu Val Ile Ala Asp Thr Tyr Glu 170 175 180 gca gcc gca ggc cgc acc aca tca aga gtc ctc gtt gcg gaa gtt atc 691 Ala Ala Ala Gly Arg Thr Thr Ser Arg Val Leu Val Ala Glu Val Ile 185 190 195 acc gag ttg gtg gtt cgc gac ttc cca caa acc cgt gtg ctg cct ttc 739 Thr Glu Leu Val Val Arg Asp Phe Pro Gln Thr Arg Val Leu Pro Phe 200 205 210 gtg gat ggc gaa tca cca gtc tcc tcg att agt taagctttgg gagttggtgc 792 Val Asp Gly Glu Ser Pro Val Ser Ser Ile Ser 215 220 tcagcaccat 802 <210> 262 <211> 224 <212> PRT <213> Corynebacterium glutamicum <400> 262 Val Ala Leu Met Thr Asn Lys Thr Arg Ala Leu Leu Ile Gly Gly His 1 5 10 15 Gly Lys Val Ala Leu Leu Ala Thr Pro Met Leu Ile Asp Ala Ser Val 20 25 30 Gln Val Thr Ser Met Tyr Arg Asn Pro Asp His Arg Ser Glu Ile Glu 35 40 45 Ala Leu Gly Ala Thr Thr Leu Glu Arg Asp Val Thr Thr Leu Ser Val 50 55 60 Glu Asp Trp Ala Asp Leu Leu Lys Asp Phe Asp Val Val Val Trp Ser 65 70 75 80 Ala Gly Asn Gly Gly Lys Asn Gly Ala Asp Ala Thr Tyr Ala Ile Asp 85 90 95 Arg Asp Ala Ala Ile Ala Ser Ile Asp Gly Ala Ala Ser Leu Gly Glu 100 105 110 Lys Ala Pro Arg Tyr Ile Met Val Ser Tyr Ile Gly Ser Ser Thr His 115 120 125 Thr Ile Asp Pro Ser Ala Ser Phe Tyr Pro Tyr Ala Glu Ser Lys Lys 130 135 140 Ala Ala Asp Glu His Leu Ser Ser Thr Asn Leu Asp Tyr Leu Ile Leu 145 150 155 160 Ala Pro Ala Ala Leu Thr Leu Asp Glu Val Asn Gly Val Glu Val Ile 165 170 175 Ala Asp Thr Tyr Glu Ala Ala Ala Gly Arg Thr Thr Ser Arg Val Leu 180 185 190 Val Ala Glu Val Ile Thr Glu Leu Val Val Arg Asp Phe Pro Gln Thr 195 200 205 Arg Val Leu Pro Phe Val Asp Gly Glu Ser Pro Val Ser Ser Ile Ser 210 215 220 <210> 263 <211> 1516 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1486) <223> RXA02219 <400> 263 tcaggaacgc atgaagccag tggaaaagga acagggcttg gttattcgta tccagtctga 60 agccttgttc aacgcggtta atgagatcta gggggtgcac atg gat gat ttt tct 115 Met Asp Asp Phe Ser 1 5 gca tcg cta ggt ttt act gac cgt tcc tcg agg gga att ctg gac acc 163 Ala Ser Leu Gly Phe Thr Asp Arg Ser Ser Arg Gly Ile Leu Asp Thr 10 15 20 atc gag atg att gag aag tat cgt ctt gat att cgc acc gtg acc atg 211 Ile Glu Met Ile Glu Lys Tyr Arg Leu Asp Ile Arg Thr Val Thr Met 25 30 35 gga atc agc ctg ttg gaa tgc gcg cgt ggc tcg atg gaa gag acc gcg 259 Gly Ile Ser Leu Leu Glu Cys Ala Arg Gly Ser Met Glu Glu Thr Ala 40 45 50 acg gct gtt tat gat cgc gtg acg tca cag gct gca cgt ctg gtt gag 307 Thr Ala Val Tyr Asp Arg Val Thr Ser Gln Ala Ala Arg Leu Val Glu 55 60 65 gtt tgt gaa ggc att gag cgt gaa ttg ggc att ccc att gtg aat aag 355 Val Cys Glu Gly Ile Glu Arg Glu Leu Gly Ile Pro Ile Val Asn Lys 70 75 80 85 cgc atc tcg gtg act cca att gcc ctg gtg act gct ggt tgc agt ggc 403 Arg Ile Ser Val Thr Pro Ile Ala Leu Val Thr Ala Gly Cys Ser Gly 90 95 100 gat ccc gtt gac gtt gct cga gcc tta gat aag gca gca aaa gat gtc 451 Asp Pro Val Asp Val Ala Arg Ala Leu Asp Lys Ala Ala Lys Asp Val 105 110 115 gga gtg aac ttc atc ggc ggg tat tca gca ctg gtt gaa aaa ggt gga 499 Gly Val Asn Phe Ile Gly Gly Tyr Ser Ala Leu Val Glu Lys Gly Gly 120 125 130 acc acc tcc gat att cgg ctg atc cgc tcc att ccc gag gca ttg agc 547 Thr Thr Ser Asp Ile Arg Leu Ile Arg Ser Ile Pro Glu Ala Leu Ser 135 140 145 aca acc gat gtg gtg tgt gga tcc gtc aat gtg gcg tcg tct cgc gcg 595 Thr Thr Asp Val Val Cys Gly Ser Val Asn Val Ala Ser Ser Arg Ala 150 155 160 165 ggt atc aac atg aac gca gtc aat gag atg ggc aag gtg gtc aag caa 643 Gly Ile Asn Met Asn Ala Val Asn Glu Met Gly Lys Val Val Lys Gln 170 175 180 gca gct gaa ttg acc aaa gat cgc tcc gcc atc gca tgt gca aag cta 691 Ala Ala Glu Leu Thr Lys Asp Arg Ser Ala Ile Ala Cys Ala Lys Leu 185 190 195 gtg gtc ttt gcc aat tct gtg ggc gat aat cca ttc atg gct ggc gct 739 Val Val Phe Ala Asn Ser Val Gly Asp Asn Pro Phe Met Ala Gly Ala 200 205 210 ttc cac ggc att gag gag ccg gat tgt gtg gtc agc gtt ggt gtc tca 787 Phe His Gly Ile Glu Glu Pro Asp Cys Val Val Ser Val Gly Val Ser 215 220 225 gga cca ggc gtg gtt agt cgc gcg ctg ggc aat ctt caa ggt gcc acc 835 Gly Pro Gly Val Val Ser Arg Ala Leu Gly Asn Leu Gln Gly Ala Thr 230 235 240 245 ctt gat caa gtc gca gaa gag atc aag aaa gcg gcc ttc aag atc act 883 Leu Asp Gln Val Ala Glu Glu Ile Lys Lys Ala Ala Phe Lys Ile Thr 250 255 260 cgt act gga caa ctg gtt ggt gcg atg gcc tca gaa cgc cta gga gtt 931 Arg Thr Gly Gln Leu Val Gly Ala Met Ala Ser Glu Arg Leu Gly Val 265 270 275 cct ttc ggc atc gtt gat ctt tcg ctc gct ccc act gct gaa gtg ggc 979 Pro Phe Gly Ile Val Asp Leu Ser Leu Ala Pro Thr Ala Glu Val Gly 280 285 290 gat tcc gtg gca aat atc ctt gag gtc atg ggt ctt gac cag gtg ggc 1027 Asp Ser Val Ala Asn Ile Leu Glu Val Met Gly Leu Asp Gln Val Gly 295 300 305 aca cat ggc acc acc gcg gca ctc gca ctg ctc aac gac gcg gtg aaa 1075 Thr His Gly Thr Thr Ala Ala Leu Ala Leu Leu Asn Asp Ala Val Lys 310 315 320 325 aag ggt ggc atg atg gcc tgc tca cgt gtc ggc ggc ttg tcc gga tcc 1123 Lys Gly Gly Met Met Ala Cys Ser Arg Val Gly Gly Leu Ser Gly Ser 330 335 340 ttc att cca gtt tct gaa gat aaa ggc atg atc gat gcg gtt cgc aca 1171 Phe Ile Pro Val Ser Glu Asp Lys Gly Met Ile Asp Ala Val Arg Thr 345 350 355 gga gca att tct att gac aag ctc gaa gcg atg acc gcg atc tgc tca 1219 Gly Ala Ile Ser Ile Asp Lys Leu Glu Ala Met Thr Ala Ile Cys Ser 360 365 370 gtt ggt ttg gat atg att gcg atc cct ggc gac acc ccg gcg gaa act 1267 Val Gly Leu Asp Met Ile Ala Ile Pro Gly Asp Thr Pro Ala Glu Thr 375 380 385 att tcg ggc atg atc gcg gac gaa gca gcc atc ggt gtg atg aat cat 1315 Ile Ser Gly Met Ile Ala Asp Glu Ala Ala Ile Gly Val Met Asn His 390 395 400 405 aag act aca gct gtg cgt gtt att cct gtt cca gga act gtc cct ggc 1363 Lys Thr Thr Ala Val Arg Val Ile Pro Val Pro Gly Thr Val Pro Gly 410 415 420 gat gag gta gat ttc ggt ggc ttg ctg ggt tac gcg ccg gtc att cca 1411 Asp Glu Val Asp Phe Gly Gly Leu Leu Gly Tyr Ala Pro Val Ile Pro 425 430 435 gta aat acc gtg gga aat agt gag ttt att cac cgc ggc ggc ttc att 1459 Val Asn Thr Val Gly Asn Ser Glu Phe Ile His Arg Gly Gly Phe Ile 440 445 450 cca gca ccc gtt cac ggg ttt aga aac taggagatcc ggggccttta 1506 Pro Ala Pro Val His Gly Phe Arg Asn 455 460 cctgccattt 1516 <210> 264 <211> 462 <212> PRT <213> Corynebacterium glutamicum <400> 264 Met Asp Asp Phe Ser Ala Ser Leu Gly Phe Thr Asp Arg Ser Ser Arg 1 5 10 15 Gly Ile Leu Asp Thr Ile Glu Met Ile Glu Lys Tyr Arg Leu Asp Ile 20 25 30 Arg Thr Val Thr Met Gly Ile Ser Leu Leu Glu Cys Ala Arg Gly Ser 35 40 45 Met Glu Glu Thr Ala Thr Ala Val Tyr Asp Arg Val Thr Ser Gln Ala 50 55 60 Ala Arg Leu Val Glu Val Cys Glu Gly Ile Glu Arg Glu Leu Gly Ile 65 70 75 80 Pro Ile Val Asn Lys Arg Ile Ser Val Thr Pro Ile Ala Leu Val Thr 85 90 95 Ala Gly Cys Ser Gly Asp Pro Val Asp Val Ala Arg Ala Leu Asp Lys 100 105 110 Ala Ala Lys Asp Val Gly Val Asn Phe Ile Gly Gly Tyr Ser Ala Leu 115 120 125 Val Glu Lys Gly Gly Thr Thr Ser Asp Ile Arg Leu Ile Arg Ser Ile 130 135 140 Pro Glu Ala Leu Ser Thr Thr Asp Val Val Cys Gly Ser Val Asn Val 145 150 155 160 Ala Ser Ser Arg Ala Gly Ile Asn Met Asn Ala Val Asn Glu Met Gly 165 170 175 Lys Val Val Lys Gln Ala Ala Glu Leu Thr Lys Asp Arg Ser Ala Ile 180 185 190 Ala Cys Ala Lys Leu Val Val Phe Ala Asn Ser Val Gly Asp Asn Pro 195 200 205 Phe Met Ala Gly Ala Phe His Gly Ile Glu Glu Pro Asp Cys Val Val 210 215 220 Ser Val Gly Val Ser Gly Pro Gly Val Val Ser Arg Ala Leu Gly Asn 225 230 235 240 Leu Gln Gly Ala Thr Leu Asp Gln Val Ala Glu Glu Ile Lys Lys Ala 245 250 255 Ala Phe Lys Ile Thr Arg Thr Gly Gln Leu Val Gly Ala Met Ala Ser 260 265 270 Glu Arg Leu Gly Val Pro Phe Gly Ile Val Asp Leu Ser Leu Ala Pro 275 280 285 Thr Ala Glu Val Gly Asp Ser Val Ala Asn Ile Leu Glu Val Met Gly 290 295 300 Leu Asp Gln Val Gly Thr His Gly Thr Thr Ala Ala Leu Ala Leu Leu 305 310 315 320 Asn Asp Ala Val Lys Lys Gly Gly Met Met Ala Cys Ser Arg Val Gly 325 330 335 Gly Leu Ser Gly Ser Phe Ile Pro Val Ser Glu Asp Lys Gly Met Ile 340 345 350 Asp Ala Val Arg Thr Gly Ala Ile Ser Ile Asp Lys Leu Glu Ala Met 355 360 365 Thr Ala Ile Cys Ser Val Gly Leu Asp Met Ile Ala Ile Pro Gly Asp 370 375 380 Thr Pro Ala Glu Thr Ile Ser Gly Met Ile Ala Asp Glu Ala Ala Ile 385 390 395 400 Gly Val Met Asn His Lys Thr Thr Ala Val Arg Val Ile Pro Val Pro 405 410 415 Gly Thr Val Pro Gly Asp Glu Val Asp Phe Gly Gly Leu Leu Gly Tyr 420 425 430 Ala Pro Val Ile Pro Val Asn Thr Val Gly Asn Ser Glu Phe Ile His 435 440 445 Arg Gly Gly Phe Ile Pro Ala Pro Val His Gly Phe Arg Asn 450 455 460 <210> 265 <211> 1492 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1462) <223> RXA02221 <400> 265 ttcaatgata tttgctctga tttttggttc tcgtctaatt tcattatttt gtcacgccag 60 ccatcacgac ttcataccca ccaattgaaa gtaaagtcca atg ttt acc gca tcc 115 Met Phe Thr Ala Ser 1 5 att cct act tat gaa tta ggg tct ttc agc aag ggc tcc tac gtt gag 163 Ile Pro Thr Tyr Glu Leu Gly Ser Phe Ser Lys Gly Ser Tyr Val Glu 10 15 20 atc aaa gga act tac ttc tac cct gac acg cta aat act tta ttt aga 211 Ile Lys Gly Thr Tyr Phe Tyr Pro Asp Thr Leu Asn Thr Leu Phe Arg 25 30 35 aat tct ggg gca aaa gac aac gaa gag ttc ttt gta gac gta act ctt 259 Asn Ser Gly Ala Lys Asp Asn Glu Glu Phe Phe Val Asp Val Thr Leu 40 45 50 gtt cca gaa cca gat aat ccg cat agc act cga ggc cat gcc att tca 307 Val Pro Glu Pro Asp Asn Pro His Ser Thr Arg Gly His Ala Ile Ser 55 60 65 gtc cgc tgg aat gat ctc gta ata gga cat att gcc tcg gat atg act 355 Val Arg Trp Asn Asp Leu Val Ile Gly His Ile Ala Ser Asp Met Thr 70 75 80 85 gaa aaa ttc caa caa gtg cga cga gtt gca gct agt ggc tac gat gct 403 Glu Lys Phe Gln Gln Val Arg Arg Val Ala Ala Ser Gly Tyr Asp Ala 90 95 100 cga gtc tct gct cgg att tgg acg aat aca aac tat aag aat gaa cga 451 Arg Val Ser Ala Arg Ile Trp Thr Asn Thr Asn Tyr Lys Asn Glu Arg 105 110 115 gat ttt tgg gta tct gtt aag ctc ccc gat cca gat ttc ctt gtt cct 499 Asp Phe Trp Val Ser Val Lys Leu Pro Asp Pro Asp Phe Leu Val Pro 120 125 130 ctt aat gat cct ccc cat gac ggg ttt acc ctc ctc cct tat gga aca 547 Leu Asn Asp Pro Pro His Asp Gly Phe Thr Leu Leu Pro Tyr Gly Thr 135 140 145 gca atc caa gtc acc aag gaa tct gat cac atg gac gtg ctc tca gaa 595 Ala Ile Gln Val Thr Lys Glu Ser Asp His Met Asp Val Leu Ser Glu 150 155 160 165 ttc gtg cct cca tct gga caa ggt cag att ctc gta tcg cta cac atc 643 Phe Val Pro Pro Ser Gly Gln Gly Gln Ile Leu Val Ser Leu His Ile 170 175 180 att aac gca ggc gtg aga aaa gaa tgg gat ggc att gaa gtt cgg ctc 691 Ile Asn Ala Gly Val Arg Lys Glu Trp Asp Gly Ile Glu Val Arg Leu 185 190 195 gat aat caa cgg atc gga gag ctt aca aag gcc agt tca gaa aaa ttc 739 Asp Asn Gln Arg Ile Gly Glu Leu Thr Lys Ala Ser Ser Glu Lys Phe 200 205 210 gca ccc gta gtg cga cat ttc gat gac cta gga ctt agt aca cta tgt 787 Ala Pro Val Val Arg His Phe Asp Asp Leu Gly Leu Ser Thr Leu Cys 215 220 225 cgt gcg ctc atc aag ggg tca tca cta gct gct gaa gta act cta tat 835 Arg Ala Leu Ile Lys Gly Ser Ser Leu Ala Ala Glu Val Thr Leu Tyr 230 235 240 245 gga gct cgt gca cat gag ctt tcc gaa gaa gac tta gaa cct aaa agc 883 Gly Ala Arg Ala His Glu Leu Ser Glu Glu Asp Leu Glu Pro Lys Ser 250 255 260 tct tcc cca ttg ccc agg ttg gtt gaa tac cag tca aat ccg ttt aat 931 Ser Ser Pro Leu Pro Arg Leu Val Glu Tyr Gln Ser Asn Pro Phe Asn 265 270 275 tat caa gtc ccc aac agg tgg ccc ggc gag cag aat caa cgt gct cct 979 Tyr Gln Val Pro Asn Arg Trp Pro Gly Glu Gln Asn Gln Arg Ala Pro 280 285 290 aag tcg caa aag tct tct tca tca cct ttc gca gcg tat cgc ggg cca 1027 Lys Ser Gln Lys Ser Ser Ser Ser Pro Phe Ala Ala Tyr Arg Gly Pro 295 300 305 tcg caa cct agt aaa tca ctc aca ccg ttt gta gcg cag aca cct gcg 1075 Ser Gln Pro Ser Lys Ser Leu Thr Pro Phe Val Ala Gln Thr Pro Ala 310 315 320 325 cct cag cct agt gat cga ttt att gat tgg gat tca ttg ctt caa ccg 1123 Pro Gln Pro Ser Asp Arg Phe Ile Asp Trp Asp Ser Leu Leu Gln Pro 330 335 340 gac gga act cca aga gct acg cca ttc caa aga gga gta acc cgc ggg 1171 Asp Gly Thr Pro Arg Ala Thr Pro Phe Gln Arg Gly Val Thr Arg Gly 345 350 355 tta att ggc aag cat ttt tcg aat caa aaa tct cca aga att gac ttt 1219 Leu Ile Gly Lys His Phe Ser Asn Gln Lys Ser Pro Arg Ile Asp Phe 360 365 370 gca acg gtg ggg caa tgt gat gca att ctc cga act ttc gga gag ccg 1267 Ala Thr Val Gly Gln Cys Asp Ala Ile Leu Arg Thr Phe Gly Glu Pro 375 380 385 acc gac aag ctt tat aaa gac ggc agg act tct tgg cct ttg tgg tgg 1315 Thr Asp Lys Leu Tyr Lys Asp Gly Arg Thr Ser Trp Pro Leu Trp Trp 390 395 400 405 gcg ctc atg gcg ata gtc acc ctt ctc gtc atg ttg ctg aac ttt att 1363 Ala Leu Met Ala Ile Val Thr Leu Leu Val Met Leu Leu Asn Phe Ile 410 415 420 cca gga att ggt ccg atc ttc cca ctt atc gga ttg atc gta ctt ggt 1411 Pro Gly Ile Gly Pro Ile Phe Pro Leu Ile Gly Leu Ile Val Leu Gly 425 430 435 cat cac ttt tgg act cgc cga aaa ctt aac cca cca ttc ggt aga tca 1459 His His Phe Trp Thr Arg Arg Lys Leu Asn Pro Pro Phe Gly Arg Ser 440 445 450 aaa tagatattct catcaaatat cgctgatgca 1492 Lys <210> 266 <211> 454 <212> PRT <213> Corynebacterium glutamicum <400> 266 Met Phe Thr Ala Ser Ile Pro Thr Tyr Glu Leu Gly Ser Phe Ser Lys 1 5 10 15 Gly Ser Tyr Val Glu Ile Lys Gly Thr Tyr Phe Tyr Pro Asp Thr Leu 20 25 30 Asn Thr Leu Phe Arg Asn Ser Gly Ala Lys Asp Asn Glu Glu Phe Phe 35 40 45 Val Asp Val Thr Leu Val Pro Glu Pro Asp Asn Pro His Ser Thr Arg 50 55 60 Gly His Ala Ile Ser Val Arg Trp Asn Asp Leu Val Ile Gly His Ile 65 70 75 80 Ala Ser Asp Met Thr Glu Lys Phe Gln Gln Val Arg Arg Val Ala Ala 85 90 95 Ser Gly Tyr Asp Ala Arg Val Ser Ala Arg Ile Trp Thr Asn Thr Asn 100 105 110 Tyr Lys Asn Glu Arg Asp Phe Trp Val Ser Val Lys Leu Pro Asp Pro 115 120 125 Asp Phe Leu Val Pro Leu Asn Asp Pro Pro His Asp Gly Phe Thr Leu 130 135 140 Leu Pro Tyr Gly Thr Ala Ile Gln Val Thr Lys Glu Ser Asp His Met 145 150 155 160 Asp Val Leu Ser Glu Phe Val Pro Pro Ser Gly Gln Gly Gln Ile Leu 165 170 175 Val Ser Leu His Ile Ile Asn Ala Gly Val Arg Lys Glu Trp Asp Gly 180 185 190 Ile Glu Val Arg Leu Asp Asn Gln Arg Ile Gly Glu Leu Thr Lys Ala 195 200 205 Ser Ser Glu Lys Phe Ala Pro Val Val Arg His Phe Asp Asp Leu Gly 210 215 220 Leu Ser Thr Leu Cys Arg Ala Leu Ile Lys Gly Ser Ser Leu Ala Ala 225 230 235 240 Glu Val Thr Leu Tyr Gly Ala Arg Ala His Glu Leu Ser Glu Glu Asp 245 250 255 Leu Glu Pro Lys Ser Ser Ser Pro Leu Pro Arg Leu Val Glu Tyr Gln 260 265 270 Ser Asn Pro Phe Asn Tyr Gln Val Pro Asn Arg Trp Pro Gly Glu Gln 275 280 285 Asn Gln Arg Ala Pro Lys Ser Gln Lys Ser Ser Ser Ser Pro Phe Ala 290 295 300 Ala Tyr Arg Gly Pro Ser Gln Pro Ser Lys Ser Leu Thr Pro Phe Val 305 310 315 320 Ala Gln Thr Pro Ala Pro Gln Pro Ser Asp Arg Phe Ile Asp Trp Asp 325 330 335 Ser Leu Leu Gln Pro Asp Gly Thr Pro Arg Ala Thr Pro Phe Gln Arg 340 345 350 Gly Val Thr Arg Gly Leu Ile Gly Lys His Phe Ser Asn Gln Lys Ser 355 360 365 Pro Arg Ile Asp Phe Ala Thr Val Gly Gln Cys Asp Ala Ile Leu Arg 370 375 380 Thr Phe Gly Glu Pro Thr Asp Lys Leu Tyr Lys Asp Gly Arg Thr Ser 385 390 395 400 Trp Pro Leu Trp Trp Ala Leu Met Ala Ile Val Thr Leu Leu Val Met 405 410 415 Leu Leu Asn Phe Ile Pro Gly Ile Gly Pro Ile Phe Pro Leu Ile Gly 420 425 430 Leu Ile Val Leu Gly His His Phe Trp Thr Arg Arg Lys Leu Asn Pro 435 440 445 Pro Phe Gly Arg Ser Lys 450 <210> 267 <211> 1003 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(973) <223> RXA02267 <400> 267 tgcgctcggc aagtgttttg cttatcgacg tctccccaca taacaatccc aactcgaagc 60 accaacgatt caagccttat cagttttgta caggaaaata gtg caa aaa tgg ggt 115 Val Gln Lys Trp Gly 1 5 tta agc ttc gtg gag agg att gtc atc atg aac aac gtg caa cag ttt 163 Leu Ser Phe Val Glu Arg Ile Val Ile Met Asn Asn Val Gln Gln Phe 10 15 20 cat cga ttt ttt gat gat tcc gca gtc tat tat ccc tgc ttc gtc ccg 211 His Arg Phe Phe Asp Asp Ser Ala Val Tyr Tyr Pro Cys Phe Val Pro 25 30 35 ctt gac cga gcc atc ggc gaa cac ttt gat cgt cag aac aaa ccg atg 259 Leu Asp Arg Ala Ile Gly Glu His Phe Asp Arg Gln Asn Lys Pro Met 40 45 50 tcc aga ttc atc gga acg ctc att ctg ccg tta gcc aaa ctg gaa gaa 307 Ser Arg Phe Ile Gly Thr Leu Ile Leu Pro Leu Ala Lys Leu Glu Glu 55 60 65 gcc gcc caa tac acc ggc gat gaa gtc ctt cgc gtg tcg gca gta atc 355 Ala Ala Gln Tyr Thr Gly Asp Glu Val Leu Arg Val Ser Ala Val Ile 70 75 80 85 agt act gat ggg ctc gct gat ctg cga agg gat ttt tac gaa ctc ccc 403 Ser Thr Asp Gly Leu Ala Asp Leu Arg Arg Asp Phe Tyr Glu Leu Pro 90 95 100 aac atc gac atc gcc tcg gtg gaa atc aag ctg gtc ggc gca gcc ctc 451 Asn Ile Asp Ile Ala Ser Val Glu Ile Lys Leu Val Gly Ala Ala Leu 105 110 115 acc aac acc gct tgg ttg gga gat gtg gaa aaa ctc atc caa caa cat 499 Thr Asn Thr Ala Trp Leu Gly Asp Val Glu Lys Leu Ile Gln Gln His 120 125 130 cgc aac act ttc gta tgg gtt gag att ccg aca gcc ctg gtc acc gca 547 Arg Asn Thr Phe Val Trp Val Glu Ile Pro Thr Ala Leu Val Thr Ala 135 140 145 gat att gtc cga aaa ctc cgc cac atg gga gct ggc ctg aaa tac aga 595 Asp Ile Val Arg Lys Leu Arg His Met Gly Ala Gly Leu Lys Tyr Arg 150 155 160 165 act gga ggt gat agg gaa gag ctc ttc ccc tca ccg cag gac ttg gtc 643 Thr Gly Gly Asp Arg Glu Glu Leu Phe Pro Ser Pro Gln Asp Leu Val 170 175 180 act gtg ctg cgc acc gcc atc gat gct gca ttg ccg ttt aaa ctc act 691 Thr Val Leu Arg Thr Ala Ile Asp Ala Ala Leu Pro Phe Lys Leu Thr 185 190 195 gca ggc ctg cat cgt gct ctc agg tat cgt gac gag aaa acc ggc cga 739 Ala Gly Leu His Arg Ala Leu Arg Tyr Arg Asp Glu Lys Thr Gly Arg 200 205 210 ctt cac ttc gga ttc ctc aac att gca gcc gcc gtg gcg aca ctt cgt 787 Leu His Phe Gly Phe Leu Asn Ile Ala Ala Ala Val Ala Thr Leu Arg 215 220 225 gct gga aaa ggc gag gca gag gca ctg aag atc ctt gaa ggc gat gat 835 Ala Gly Lys Gly Glu Ala Glu Ala Leu Lys Ile Leu Glu Gly Asp Asp 230 235 240 245 gcc gct ccg ctt att cac gca cta caa agc ggc gaa aac tgg cgg gat 883 Ala Ala Pro Leu Ile His Ala Leu Gln Ser Gly Glu Asn Trp Arg Asp 250 255 260 tcc ttc cgc agc ttc agt acc tgc aat gtt gtt gaa cca ctc aac act 931 Ser Phe Arg Ser Phe Ser Thr Cys Asn Val Val Glu Pro Leu Asn Thr 265 270 275 ctg att gat ctt gat gtg ttg gcg gaa gga gac gta cat ccc 973 Leu Ile Asp Leu Asp Val Leu Ala Glu Gly Asp Val His Pro 280 285 290 taaggatcga cgctagttag atcggttttt 1003 <210> 268 <211> 291 <212> PRT <213> Corynebacterium glutamicum <400> 268 Val Gln Lys Trp Gly Leu Ser Phe Val Glu Arg Ile Val Ile Met Asn 1 5 10 15 Asn Val Gln Gln Phe His Arg Phe Phe Asp Asp Ser Ala Val Tyr Tyr 20 25 30 Pro Cys Phe Val Pro Leu Asp Arg Ala Ile Gly Glu His Phe Asp Arg 35 40 45 Gln Asn Lys Pro Met Ser Arg Phe Ile Gly Thr Leu Ile Leu Pro Leu 50 55 60 Ala Lys Leu Glu Glu Ala Ala Gln Tyr Thr Gly Asp Glu Val Leu Arg 65 70 75 80 Val Ser Ala Val Ile Ser Thr Asp Gly Leu Ala Asp Leu Arg Arg Asp 85 90 95 Phe Tyr Glu Leu Pro Asn Ile Asp Ile Ala Ser Val Glu Ile Lys Leu 100 105 110 Val Gly Ala Ala Leu Thr Asn Thr Ala Trp Leu Gly Asp Val Glu Lys 115 120 125 Leu Ile Gln Gln His Arg Asn Thr Phe Val Trp Val Glu Ile Pro Thr 130 135 140 Ala Leu Val Thr Ala Asp Ile Val Arg Lys Leu Arg His Met Gly Ala 145 150 155 160 Gly Leu Lys Tyr Arg Thr Gly Gly Asp Arg Glu Glu Leu Phe Pro Ser 165 170 175 Pro Gln Asp Leu Val Thr Val Leu Arg Thr Ala Ile Asp Ala Ala Leu 180 185 190 Pro Phe Lys Leu Thr Ala Gly Leu His Arg Ala Leu Arg Tyr Arg Asp 195 200 205 Glu Lys Thr Gly Arg Leu His Phe Gly Phe Leu Asn Ile Ala Ala Ala 210 215 220 Val Ala Thr Leu Arg Ala Gly Lys Gly Glu Ala Glu Ala Leu Lys Ile 225 230 235 240 Leu Glu Gly Asp Asp Ala Ala Pro Leu Ile His Ala Leu Gln Ser Gly 245 250 255 Glu Asn Trp Arg Asp Ser Phe Arg Ser Phe Ser Thr Cys Asn Val Val 260 265 270 Glu Pro Leu Asn Thr Leu Ile Asp Leu Asp Val Leu Ala Glu Gly Asp 275 280 285 Val His Pro 290 <210> 269 <211> 688 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(658) <223> RXA02271 <400> 269 cactccccta tcctaagcca catctcggtt tattaaactg ttagtgaatt ctcacccgca 60 acactggtgt atttcagtta catccgtatg gttattggtt atg agc ttt ctt aac 115 Met Ser Phe Leu Asn 1 5 tct gca aaa acc aag acc gta gcc ctc acc gca acc ttc gtt ggt gca 163 Ser Ala Lys Thr Lys Thr Val Ala Leu Thr Ala Thr Phe Val Gly Ala 10 15 20 gca acc ctt gca act cct gca atc gca tcc gct gac atc gtc gac aac 211 Ala Thr Leu Ala Thr Pro Ala Ile Ala Ser Ala Asp Ile Val Asp Asn 25 30 35 gcc ctc gca gcc ctc cca tcc ggt gag atc agc tgc tcc cag gct gaa 259 Ala Leu Ala Ala Leu Pro Ser Gly Glu Ile Ser Cys Ser Gln Ala Glu 40 45 50 aag tac tgg acc acc gaa gct gat tac aac agc aag gtt gca cag gcc 307 Lys Tyr Trp Thr Thr Glu Ala Asp Tyr Asn Ser Lys Val Ala Gln Ala 55 60 65 aac gcc ttg gca atg ttt gac tcc cgc ggc cca cag atc cag gca gct 355 Asn Ala Leu Ala Met Phe Asp Ser Arg Gly Pro Gln Ile Gln Ala Ala 70 75 80 85 ctc gca cgc gtt gac gaa gca gca aac cgc tgc gga ctc aag ggc ggc 403 Leu Ala Arg Val Asp Glu Ala Ala Asn Arg Cys Gly Leu Lys Gly Gly 90 95 100 acc gta gct gcg cag gct gag gca act gag gct gcg cct gcc gct cca 451 Thr Val Ala Ala Gln Ala Glu Ala Thr Glu Ala Ala Pro Ala Ala Pro 105 110 115 gca cct gca ccg cag gat aac acc ggc act tct cag act gcc cct gcc 499 Ala Pro Ala Pro Gln Asp Asn Thr Gly Thr Ser Gln Thr Ala Pro Ala 120 125 130 cca gca gca cca gca gca cca gca gct acc cct gtg gtt aac ctt gca 547 Pro Ala Ala Pro Ala Ala Pro Ala Ala Thr Pro Val Val Asn Leu Ala 135 140 145 cct gca gga tca cca act ttc acc att gaa gtt cca gga gtt ggc ggg 595 Pro Ala Gly Ser Pro Thr Phe Thr Ile Glu Val Pro Gly Val Gly Gly 150 155 160 165 gtt cag ctg cca gat cta tac caa atc gtc caa cag ttc ttg gca cag 643 Val Gln Leu Pro Asp Leu Tyr Gln Ile Val Gln Gln Phe Leu Ala Gln 170 175 180 ttc gga atc aag atc taaatctatt cacatccctt aaccctcacg 688 Phe Gly Ile Lys Ile 185 <210> 270 <211> 186 <212> PRT <213> Corynebacterium glutamicum <400> 270 Met Ser Phe Leu Asn Ser Ala Lys Thr Lys Thr Val Ala Leu Thr Ala 1 5 10 15 Thr Phe Val Gly Ala Ala Thr Leu Ala Thr Pro Ala Ile Ala Ser Ala 20 25 30 Asp Ile Val Asp Asn Ala Leu Ala Ala Leu Pro Ser Gly Glu Ile Ser 35 40 45 Cys Ser Gln Ala Glu Lys Tyr Trp Thr Thr Glu Ala Asp Tyr Asn Ser 50 55 60 Lys Val Ala Gln Ala Asn Ala Leu Ala Met Phe Asp Ser Arg Gly Pro 65 70 75 80 Gln Ile Gln Ala Ala Leu Ala Arg Val Asp Glu Ala Ala Asn Arg Cys 85 90 95 Gly Leu Lys Gly Gly Thr Val Ala Ala Gln Ala Glu Ala Thr Glu Ala 100 105 110 Ala Pro Ala Ala Pro Ala Pro Ala Pro Gln Asp Asn Thr Gly Thr Ser 115 120 125 Gln Thr Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Ala Thr Pro 130 135 140 Val Val Asn Leu Ala Pro Ala Gly Ser Pro Thr Phe Thr Ile Glu Val 145 150 155 160 Pro Gly Val Gly Gly Val Gln Leu Pro Asp Leu Tyr Gln Ile Val Gln 165 170 175 Gln Phe Leu Ala Gln Phe Gly Ile Lys Ile 180 185 <210> 271 <211> 1984 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1954) <223> RXA02280 <400> 271 ggtcgaggtg tcgtagatgt caatgagctt cgcgattgcg tcatcgatcg ttgttgcttc 60 catgcgcacc acactatctt tctgcacgcc ctgatgccct gtg gat tca aaa ctg 115 Val Asp Ser Lys Leu 1 5 tgc ttt tat agg cgt atg caa gaa tcc tca cgt gat aat ttc caa gtt 163 Cys Phe Tyr Arg Arg Met Gln Glu Ser Ser Arg Asp Asn Phe Gln Val 10 15 20 gac ctc ggc ggc gtt gtt gat ctt ttg agt cgc cac att tat tcc ggt 211 Asp Leu Gly Gly Val Val Asp Leu Leu Ser Arg His Ile Tyr Ser Gly 25 30 35 ccg agg gtg tat gtg cgt gag ttg ctg cag aat gcg gtt gat gct tgt 259 Pro Arg Val Tyr Val Arg Glu Leu Leu Gln Asn Ala Val Asp Ala Cys 40 45 50 act gca cgt tct gaa cag ggt gag gag ggc tac gag ccg agt att cgt 307 Thr Ala Arg Ser Glu Gln Gly Glu Glu Gly Tyr Glu Pro Ser Ile Arg 55 60 65 att cgg ccg gtg acc aag gat cgt gcc acg ttt tca ctg gtt gat aat 355 Ile Arg Pro Val Thr Lys Asp Arg Ala Thr Phe Ser Leu Val Asp Asn 70 75 80 85 ggt acg ggc ctg acc gcg cag gag gcg cgg gaa ttg ctg gcg acg gtg 403 Gly Thr Gly Leu Thr Ala Gln Glu Ala Arg Glu Leu Leu Ala Thr Val 90 95 100 ggg cgg acg tcg aaa cgc gat gaa ttc ggt ctg cag cgg gaa ggt cgc 451 Gly Arg Thr Ser Lys Arg Asp Glu Phe Gly Leu Gln Arg Glu Gly Arg 105 110 115 ctg ggg caa ttt ggc atc ggg ctg ctt agt tgt ttc atg gtg gcg gat 499 Leu Gly Gln Phe Gly Ile Gly Leu Leu Ser Cys Phe Met Val Ala Asp 120 125 130 gag atc acc atg gtg tcg cat gcg gag ggt gcg tcg gcg att cgg tgg 547 Glu Ile Thr Met Val Ser His Ala Glu Gly Ala Ser Ala Ile Arg Trp 135 140 145 act ggt cat gcg gat ggc acc ttt aac ctg gag att ctt ggg gat gac 595 Thr Gly His Ala Asp Gly Thr Phe Asn Leu Glu Ile Leu Gly Asp Asp 150 155 160 165 gca acg gat gtc att ccg gtg ggc acg act gtg cac ctg act ccg cgc 643 Ala Thr Asp Val Ile Pro Val Gly Thr Thr Val His Leu Thr Pro Arg 170 175 180 cct gat gag cgc acg ttg ctg acg gaa aat tcc gtg gtc acc att gct 691 Pro Asp Glu Arg Thr Leu Leu Thr Glu Asn Ser Val Val Thr Ile Ala 185 190 195 agt aat tat ggc cgc tac ctg ccg att cct att gtg gtg cag ggt gag 739 Ser Asn Tyr Gly Arg Tyr Leu Pro Ile Pro Ile Val Val Gln Gly Glu 200 205 210 aaa aac acc acc atc act aca tcg ccg gtg ttt gca aag gat act gat 787 Lys Asn Thr Thr Ile Thr Thr Ser Pro Val Phe Ala Lys Asp Thr Asp 215 220 225 cag cag cac agg ctg tat gcc ggc cgg gag cgc ctt ggt aaa act cct 835 Gln Gln His Arg Leu Tyr Ala Gly Arg Glu Arg Leu Gly Lys Thr Pro 230 235 240 245 ttt gat gtc atc gat ctc acc ggt cct ggc atc gag ggt gtg gct tat 883 Phe Asp Val Ile Asp Leu Thr Gly Pro Gly Ile Glu Gly Val Ala Tyr 250 255 260 gta ttg ccg gag gcc cag gct ccg cat atg tcc agg cgt cac agt att 931 Val Leu Pro Glu Ala Gln Ala Pro His Met Ser Arg Arg His Ser Ile 265 270 275 tat gtc aac cgc atg ttg gtc tct gat ggg cct tcc acg gtg ctg ccc 979 Tyr Val Asn Arg Met Leu Val Ser Asp Gly Pro Ser Thr Val Leu Pro 280 285 290 aac tgg gcg ttc ttt gtg gaa tgt gaa atc aat tca acc gat ttg gaa 1027 Asn Trp Ala Phe Phe Val Glu Cys Glu Ile Asn Ser Thr Asp Leu Glu 295 300 305 ccc acc gca tcg cgt gaa gcg ctc atg gat gac acc gcg ttc gcg gca 1075 Pro Thr Ala Ser Arg Glu Ala Leu Met Asp Asp Thr Ala Phe Ala Ala 310 315 320 325 acc agg gaa cat atc ggt gag tgc att aaa tcg tgg ctg att aat ctc 1123 Thr Arg Glu His Ile Gly Glu Cys Ile Lys Ser Trp Leu Ile Asn Leu 330 335 340 gcc atg acc aag cct cac cgc gtg cgg gaa ttt act gcg att cat gat 1171 Ala Met Thr Lys Pro His Arg Val Arg Glu Phe Thr Ala Ile His Asp 345 350 355 ctt gcc ctg cgc gag ctg tgc caa tcg gac gcg gac ctg gct gaa acc 1219 Leu Ala Leu Arg Glu Leu Cys Gln Ser Asp Ala Asp Leu Ala Glu Thr 360 365 370 atg ttg ggt ctt ctc acc ttg gag acc tcc cgt ggt cgc atc tcg atc 1267 Met Leu Gly Leu Leu Thr Leu Glu Thr Ser Arg Gly Arg Ile Ser Ile 375 380 385 ggt gag atc acc acg ttg tcc atc acc gag gat gtg tcg ctg cag ctg 1315 Gly Glu Ile Thr Thr Leu Ser Ile Thr Glu Asp Val Ser Leu Gln Leu 390 395 400 405 gct acc acg ttg gat gat ttc agg cag ctc aac acc att gcg cgc ccg 1363 Ala Thr Thr Leu Asp Asp Phe Arg Gln Leu Asn Thr Ile Ala Arg Pro 410 415 420 gac acc ttg att att aat ggc ggc tac att cac gac agc gat ctg gct 1411 Asp Thr Leu Ile Ile Asn Gly Gly Tyr Ile His Asp Ser Asp Leu Ala 425 430 435 cgg ctc att ccc gtt cac tac cca ccg ctt acg gta tct act gct gac 1459 Arg Leu Ile Pro Val His Tyr Pro Pro Leu Thr Val Ser Thr Ala Asp 440 445 450 ctg cgc gaa tcc atg gat ctg atg gag ctt ccg ccg ctg cag gac att 1507 Leu Arg Glu Ser Met Asp Leu Met Glu Leu Pro Pro Leu Gln Asp Ile 455 460 465 gag aaa gcc aag gca ctg gat gcg cag gtc acg gaa tca ttg aag gat 1555 Glu Lys Ala Lys Ala Leu Asp Ala Gln Val Thr Glu Ser Leu Lys Asp 470 475 480 485 ttt cag atc aag ggc gca acg agg gtt ttt gaa ccc gca gat gtt cct 1603 Phe Gln Ile Lys Gly Ala Thr Arg Val Phe Glu Pro Ala Asp Val Pro 490 495 500 gcc gtg gtg atc att gat tcc aag gcg cag gcc tca cgg gat cgc aat 1651 Ala Val Val Ile Ile Asp Ser Lys Ala Gln Ala Ser Arg Asp Arg Asn 505 510 515 gaa aca caa agc gca acc act gat cgt tgg gct gac att ttg gca acg 1699 Glu Thr Gln Ser Ala Thr Thr Asp Arg Trp Ala Asp Ile Leu Ala Thr 520 525 530 gtg gat aac acg ttg agc cgt caa aca gcc aac att cca cag gat cag 1747 Val Asp Asn Thr Leu Ser Arg Gln Thr Ala Asn Ile Pro Gln Asp Gln 535 540 545 gga ctg tcg gcg ttg tgc ttg aat tgg aac aat tcg ctg gtc agg aaa 1795 Gly Leu Ser Ala Leu Cys Leu Asn Trp Asn Asn Ser Leu Val Arg Lys 550 555 560 565 ttg gcg tcc act gat gac acc gcc gtg gtg tcg cgc acg gtg cgt ttg 1843 Leu Ala Ser Thr Asp Asp Thr Ala Val Val Ser Arg Thr Val Arg Leu 570 575 580 ctc tac gtt cag gca ttg ttg tcc agc aag agg cca ctg cgg gtg aag 1891 Leu Tyr Val Gln Ala Leu Leu Ser Ser Lys Arg Pro Leu Arg Val Lys 585 590 595 gaa cgc gcg ctg ctt aat gat tcg ctg gca gat ctg gtt tct ttg tct 1939 Glu Arg Ala Leu Leu Asn Asp Ser Leu Ala Asp Leu Val Ser Leu Ser 600 605 610 ttg tca tcc gat atc taagacaatc ctccgctaat ctcgagggca 1984 Leu Ser Ser Asp Ile 615 <210> 272 <211> 618 <212> PRT <213> Corynebacterium glutamicum <400> 272 Val Asp Ser Lys Leu Cys Phe Tyr Arg Arg Met Gln Glu Ser Ser Arg 1 5 10 15 Asp Asn Phe Gln Val Asp Leu Gly Gly Val Val Asp Leu Leu Ser Arg 20 25 30 His Ile Tyr Ser Gly Pro Arg Val Tyr Val Arg Glu Leu Leu Gln Asn 35 40 45 Ala Val Asp Ala Cys Thr Ala Arg Ser Glu Gln Gly Glu Glu Gly Tyr 50 55 60 Glu Pro Ser Ile Arg Ile Arg Pro Val Thr Lys Asp Arg Ala Thr Phe 65 70 75 80 Ser Leu Val Asp Asn Gly Thr Gly Leu Thr Ala Gln Glu Ala Arg Glu 85 90 95 Leu Leu Ala Thr Val Gly Arg Thr Ser Lys Arg Asp Glu Phe Gly Leu 100 105 110 Gln Arg Glu Gly Arg Leu Gly Gln Phe Gly Ile Gly Leu Leu Ser Cys 115 120 125 Phe Met Val Ala Asp Glu Ile Thr Met Val Ser His Ala Glu Gly Ala 130 135 140 Ser Ala Ile Arg Trp Thr Gly His Ala Asp Gly Thr Phe Asn Leu Glu 145 150 155 160 Ile Leu Gly Asp Asp Ala Thr Asp Val Ile Pro Val Gly Thr Thr Val 165 170 175 His Leu Thr Pro Arg Pro Asp Glu Arg Thr Leu Leu Thr Glu Asn Ser 180 185 190 Val Val Thr Ile Ala Ser Asn Tyr Gly Arg Tyr Leu Pro Ile Pro Ile 195 200 205 Val Val Gln Gly Glu Lys Asn Thr Thr Ile Thr Thr Ser Pro Val Phe 210 215 220 Ala Lys Asp Thr Asp Gln Gln His Arg Leu Tyr Ala Gly Arg Glu Arg 225 230 235 240 Leu Gly Lys Thr Pro Phe Asp Val Ile Asp Leu Thr Gly Pro Gly Ile 245 250 255 Glu Gly Val Ala Tyr Val Leu Pro Glu Ala Gln Ala Pro His Met Ser 260 265 270 Arg Arg His Ser Ile Tyr Val Asn Arg Met Leu Val Ser Asp Gly Pro 275 280 285 Ser Thr Val Leu Pro Asn Trp Ala Phe Phe Val Glu Cys Glu Ile Asn 290 295 300 Ser Thr Asp Leu Glu Pro Thr Ala Ser Arg Glu Ala Leu Met Asp Asp 305 310 315 320 Thr Ala Phe Ala Ala Thr Arg Glu His Ile Gly Glu Cys Ile Lys Ser 325 330 335 Trp Leu Ile Asn Leu Ala Met Thr Lys Pro His Arg Val Arg Glu Phe 340 345 350 Thr Ala Ile His Asp Leu Ala Leu Arg Glu Leu Cys Gln Ser Asp Ala 355 360 365 Asp Leu Ala Glu Thr Met Leu Gly Leu Leu Thr Leu Glu Thr Ser Arg 370 375 380 Gly Arg Ile Ser Ile Gly Glu Ile Thr Thr Leu Ser Ile Thr Glu Asp 385 390 395 400 Val Ser Leu Gln Leu Ala Thr Thr Leu Asp Asp Phe Arg Gln Leu Asn 405 410 415 Thr Ile Ala Arg Pro Asp Thr Leu Ile Ile Asn Gly Gly Tyr Ile His 420 425 430 Asp Ser Asp Leu Ala Arg Leu Ile Pro Val His Tyr Pro Pro Leu Thr 435 440 445 Val Ser Thr Ala Asp Leu Arg Glu Ser Met Asp Leu Met Glu Leu Pro 450 455 460 Pro Leu Gln Asp Ile Glu Lys Ala Lys Ala Leu Asp Ala Gln Val Thr 465 470 475 480 Glu Ser Leu Lys Asp Phe Gln Ile Lys Gly Ala Thr Arg Val Phe Glu 485 490 495 Pro Ala Asp Val Pro Ala Val Val Ile Ile Asp Ser Lys Ala Gln Ala 500 505 510 Ser Arg Asp Arg Asn Glu Thr Gln Ser Ala Thr Thr Asp Arg Trp Ala 515 520 525 Asp Ile Leu Ala Thr Val Asp Asn Thr Leu Ser Arg Gln Thr Ala Asn 530 535 540 Ile Pro Gln Asp Gln Gly Leu Ser Ala Leu Cys Leu Asn Trp Asn Asn 545 550 555 560 Ser Leu Val Arg Lys Leu Ala Ser Thr Asp Asp Thr Ala Val Val Ser 565 570 575 Arg Thr Val Arg Leu Leu Tyr Val Gln Ala Leu Leu Ser Ser Lys Arg 580 585 590 Pro Leu Arg Val Lys Glu Arg Ala Leu Leu Asn Asp Ser Leu Ala Asp 595 600 605 Leu Val Ser Leu Ser Leu Ser Ser Asp Ile 610 615 <210> 273 <211> 514 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(484) <223> RXA02294 <400> 273 atgagcgtct acctcacctg gcaacaaatc caaggaatgt agataagtcg gggcaaactc 60 taagaaatca tcctggtttg tggcagggaa cattcctagg atg gga ggc atg gca 115 Met Gly Gly Met Ala 1 5 aag aca aaa cta gaa agc atc tcc gag cgc aac tcg gat gat ccg ctt 163 Lys Thr Lys Leu Glu Ser Ile Ser Glu Arg Asn Ser Asp Asp Pro Leu 10 15 20 agt tac ccc gac ctg act ctt gca cca ata tcc aca aca gtc aca gtc 211 Ser Tyr Pro Asp Leu Thr Leu Ala Pro Ile Ser Thr Thr Val Thr Val 25 30 35 gtg gtc gcc gaa gac acc cca aac gat aac ttc tca gaa ctt ctc ctc 259 Val Val Ala Glu Asp Thr Pro Asn Asp Asn Phe Ser Glu Leu Leu Leu 40 45 50 ggc gca gca gaa tca acc cgt ctt tta gga ctc gac gag ctc cac atc 307 Gly Ala Ala Glu Ser Thr Arg Leu Leu Gly Leu Asp Glu Leu His Ile 55 60 65 atc gct cca tca gtc cac cta ccc gct ctc gca gta gca gcc gcc gac 355 Ile Ala Pro Ser Val His Leu Pro Ala Leu Ala Val Ala Ala Ala Asp 70 75 80 85 atc gca cac cat ctg cca gag aaa ttc caa ttc tgt gaa gcc gaa acc 403 Ile Ala His His Leu Pro Glu Lys Phe Gln Phe Cys Glu Ala Glu Thr 90 95 100 tgc act cat ctc cac ccc gac gat gac acc tat ctc acg gct gaa tcc 451 Cys Thr His Leu His Pro Asp Asp Asp Thr Tyr Leu Thr Ala Glu Ser 105 110 115 gtt gct caa ttg ggt acg aag ctg aag tct gcg tagttgttag gagccaccac 504 Val Ala Gln Leu Gly Thr Lys Leu Lys Ser Ala 120 125 agacccgtag 514 <210> 274 <211> 128 <212> PRT <213> Corynebacterium glutamicum <400> 274 Met Gly Gly Met Ala Lys Thr Lys Leu Glu Ser Ile Ser Glu Arg Asn 1 5 10 15 Ser Asp Asp Pro Leu Ser Tyr Pro Asp Leu Thr Leu Ala Pro Ile Ser 20 25 30 Thr Thr Val Thr Val Val Val Ala Glu Asp Thr Pro Asn Asp Asn Phe 35 40 45 Ser Glu Leu Leu Leu Gly Ala Ala Glu Ser Thr Arg Leu Leu Gly Leu 50 55 60 Asp Glu Leu His Ile Ile Ala Pro Ser Val His Leu Pro Ala Leu Ala 65 70 75 80 Val Ala Ala Ala Asp Ile Ala His His Leu Pro Glu Lys Phe Gln Phe 85 90 95 Cys Glu Ala Glu Thr Cys Thr His Leu His Pro Asp Asp Asp Thr Tyr 100 105 110 Leu Thr Ala Glu Ser Val Ala Gln Leu Gly Thr Lys Leu Lys Ser Ala 115 120 125 <210> 275 <211> 910 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(880) <223> RXA02295 <400> 275 ttcccatgct aatccgcgaa aatggcactt caacagccat atactttaaa caacacaaat 60 gatgcaagac tgataccggg atgtgatagg agcgcaccac atg ggg ttg gaa tta 115 Met Gly Leu Glu Leu 1 5 gca gct agc ggg tgg ggc atc ctc atc gca ggc gcc gcc gta gcc gga 163 Ala Ala Ser Gly Trp Gly Ile Leu Ile Ala Gly Ala Ala Val Ala Gly 10 15 20 tgg atc gac gca gta atc ggc ggt ggc gga ctc gtc ctc atc ccg ctg 211 Trp Ile Asp Ala Val Ile Gly Gly Gly Gly Leu Val Leu Ile Pro Leu 25 30 35 atc ctc gcg gtc atg ccg caa ctc gca cct gtg aca gcg ctg gcc tcc 259 Ile Leu Ala Val Met Pro Gln Leu Ala Pro Val Thr Ala Leu Ala Ser 40 45 50 aac aaa ctg gca gcc gtc acc ggc acg gca tcg gcg gca ttc acc ctg 307 Asn Lys Leu Ala Ala Val Thr Gly Thr Ala Ser Ala Ala Phe Thr Leu 55 60 65 gtc agg cgc gtc aaa ccc gac aaa aaa ctg ctt gcg ctc tac gtt ctg 355 Val Arg Arg Val Lys Pro Asp Lys Lys Leu Leu Ala Leu Tyr Val Leu 70 75 80 85 gtg gca gct gtg tgc tcc ggt gca ggc gcc ctg gct gcg agt ctc att 403 Val Ala Ala Val Cys Ser Gly Ala Gly Ala Leu Ala Ala Ser Leu Ile 90 95 100 gac aaa caa atc atg cga ccg ctg atc atc gtg ttg atg ctg gtc gtt 451 Asp Lys Gln Ile Met Arg Pro Leu Ile Ile Val Leu Met Leu Val Val 105 110 115 ggc ctg atc gtg gtg ttc aaa cca aac ttc gga acc ggc gaa agc aaa 499 Gly Leu Ile Val Val Phe Lys Pro Asn Phe Gly Thr Gly Glu Ser Lys 120 125 130 gcc ctg ccc acc gga tgg aaa cgc tgg gcc gcc atc gtt gca gtc gga 547 Ala Leu Pro Thr Gly Trp Lys Arg Trp Ala Ala Ile Val Ala Val Gly 135 140 145 ctc atc gca gcc tac gac ggc atc ttc gga ccc gga acc ggc atg ttc 595 Leu Ile Ala Ala Tyr Asp Gly Ile Phe Gly Pro Gly Thr Gly Met Phe 150 155 160 165 ctc atc atg gcg ttc acc gca ctg ctc tcc caa aat ttc ctg tcc tcc 643 Leu Ile Met Ala Phe Thr Ala Leu Leu Ser Gln Asn Phe Leu Ser Ser 170 175 180 gca gcc atg gcg aag gtc gta aac acc gca aca aac ctg ggt gcg cta 691 Ala Ala Met Ala Lys Val Val Asn Thr Ala Thr Asn Leu Gly Ala Leu 185 190 195 att gta ttc atc atc ggc ggc cac atg tgg tgg acc cta gga ctc gtg 739 Ile Val Phe Ile Ile Gly Gly His Met Trp Trp Thr Leu Gly Leu Val 200 205 210 ctg gca gtc gcc aat gtc gca ggc gca caa ctc ggt gcc cga acg gtg 787 Leu Ala Val Ala Asn Val Ala Gly Ala Gln Leu Gly Ala Arg Thr Val 215 220 225 ctt ggt ggc ggt acc agg cta att aga tac gca cta cta acc ctg gtt 835 Leu Gly Gly Gly Thr Arg Leu Ile Arg Tyr Ala Leu Leu Thr Leu Val 230 235 240 245 gtc gtc atg agc gtc tac ctc acc tgg caa caa atc caa gga atg 880 Val Val Met Ser Val Tyr Leu Thr Trp Gln Gln Ile Gln Gly Met 250 255 260 tagataagtc ggggcaaact ctaagaaatc 910 <210> 276 <211> 260 <212> PRT <213> Corynebacterium glutamicum <400> 276 Met Gly Leu Glu Leu Ala Ala Ser Gly Trp Gly Ile Leu Ile Ala Gly 1 5 10 15 Ala Ala Val Ala Gly Trp Ile Asp Ala Val Ile Gly Gly Gly Gly Leu 20 25 30 Val Leu Ile Pro Leu Ile Leu Ala Val Met Pro Gln Leu Ala Pro Val 35 40 45 Thr Ala Leu Ala Ser Asn Lys Leu Ala Ala Val Thr Gly Thr Ala Ser 50 55 60 Ala Ala Phe Thr Leu Val Arg Arg Val Lys Pro Asp Lys Lys Leu Leu 65 70 75 80 Ala Leu Tyr Val Leu Val Ala Ala Val Cys Ser Gly Ala Gly Ala Leu 85 90 95 Ala Ala Ser Leu Ile Asp Lys Gln Ile Met Arg Pro Leu Ile Ile Val 100 105 110 Leu Met Leu Val Val Gly Leu Ile Val Val Phe Lys Pro Asn Phe Gly 115 120 125 Thr Gly Glu Ser Lys Ala Leu Pro Thr Gly Trp Lys Arg Trp Ala Ala 130 135 140 Ile Val Ala Val Gly Leu Ile Ala Ala Tyr Asp Gly Ile Phe Gly Pro 145 150 155 160 Gly Thr Gly Met Phe Leu Ile Met Ala Phe Thr Ala Leu Leu Ser Gln 165 170 175 Asn Phe Leu Ser Ser Ala Ala Met Ala Lys Val Val Asn Thr Ala Thr 180 185 190 Asn Leu Gly Ala Leu Ile Val Phe Ile Ile Gly Gly His Met Trp Trp 195 200 205 Thr Leu Gly Leu Val Leu Ala Val Ala Asn Val Ala Gly Ala Gln Leu 210 215 220 Gly Ala Arg Thr Val Leu Gly Gly Gly Thr Arg Leu Ile Arg Tyr Ala 225 230 235 240 Leu Leu Thr Leu Val Val Val Met Ser Val Tyr Leu Thr Trp Gln Gln 245 250 255 Ile Gln Gly Met 260 <210> 277 <211> 619 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(589) <223> RXA02296 <400> 277 gcatcatttg tgttgtttaa agtatatggc tgttgaagtg ccattttcgc ggattagcat 60 gggaatcacc agtatttctg gacggttaag gatgattcat atg cgt aat caa aca 115 Met Arg Asn Gln Thr 1 5 atc gct gcg gtc gca gct ttg gtc ctg ctc acc gcc gcc acg ccc gcg 163 Ile Ala Ala Val Ala Ala Leu Val Leu Leu Thr Ala Ala Thr Pro Ala 10 15 20 atc gct gcc acc ccg gcg aca gct gga aac gga ctc tat tcc att gac 211 Ile Ala Ala Thr Pro Ala Thr Ala Gly Asn Gly Leu Tyr Ser Ile Asp 25 30 35 atg ggc gac gag caa aag ctt acc tgc gtg ctt ttc gat gag ccc tcc 259 Met Gly Asp Glu Gln Lys Leu Thr Cys Val Leu Phe Asp Glu Pro Ser 40 45 50 acc gaa gcg cac gtc gtc gcc agc tgt gct gcg act ttc ccg gtg acc 307 Thr Glu Ala His Val Val Ala Ser Cys Ala Ala Thr Phe Pro Val Thr 55 60 65 tgg aag ctt ctc gac ggc gct cac gaa caa gcc gcg aaa ctt gaa atc 355 Trp Lys Leu Leu Asp Gly Ala His Glu Gln Ala Ala Lys Leu Glu Ile 70 75 80 85 acc cag gct caa gac ggt gaa ctc tcg gtg aca gcc agc aag cag ccg 403 Thr Gln Ala Gln Asp Gly Glu Leu Ser Val Thr Ala Ser Lys Gln Pro 90 95 100 ttg atc acc acg atg att gcg ccc acc agc atc act aag ccc atc act 451 Leu Ile Thr Thr Met Ile Ala Pro Thr Ser Ile Thr Lys Pro Ile Thr 105 110 115 gtc aat agg ctt gtg gtt gtt cct ggt gag aat gag gtt cgc ttt tat 499 Val Asn Arg Leu Val Val Val Pro Gly Glu Asn Glu Val Arg Phe Tyr 120 125 130 gct acc gat cct gat gtt tta cca gtg ctg atc acg cct gac tcc tat 547 Ala Thr Asp Pro Asp Val Leu Pro Val Leu Ile Thr Pro Asp Ser Tyr 135 140 145 gaa gtg ttg acc gat tcc gct gct aaa gtg aaa gcg aca tta 589 Glu Val Leu Thr Asp Ser Ala Ala Lys Val Lys Ala Thr Leu 150 155 160 tgaaataaac gtggatcaag gagtccggtg 619 <210> 278 <211> 163 <212> PRT <213> Corynebacterium glutamicum <400> 278 Met Arg Asn Gln Thr Ile Ala Ala Val Ala Ala Leu Val Leu Leu Thr 1 5 10 15 Ala Ala Thr Pro Ala Ile Ala Ala Thr Pro Ala Thr Ala Gly Asn Gly 20 25 30 Leu Tyr Ser Ile Asp Met Gly Asp Glu Gln Lys Leu Thr Cys Val Leu 35 40 45 Phe Asp Glu Pro Ser Thr Glu Ala His Val Val Ala Ser Cys Ala Ala 50 55 60 Thr Phe Pro Val Thr Trp Lys Leu Leu Asp Gly Ala His Glu Gln Ala 65 70 75 80 Ala Lys Leu Glu Ile Thr Gln Ala Gln Asp Gly Glu Leu Ser Val Thr 85 90 95 Ala Ser Lys Gln Pro Leu Ile Thr Thr Met Ile Ala Pro Thr Ser Ile 100 105 110 Thr Lys Pro Ile Thr Val Asn Arg Leu Val Val Val Pro Gly Glu Asn 115 120 125 Glu Val Arg Phe Tyr Ala Thr Asp Pro Asp Val Leu Pro Val Leu Ile 130 135 140 Thr Pro Asp Ser Tyr Glu Val Leu Thr Asp Ser Ala Ala Lys Val Lys 145 150 155 160 Ala Thr Leu <210> 279 <211> 1789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1759) <223> RXA02298 <400> 279 aaatcatagc gtgagatgac aaggaaagga atatttcgat ccggcaacaa cccccgcgtc 60 aggtgggatt atgccgaaaa aatcgctacg atagccactt atg act ctt cag agt 115 Met Thr Leu Gln Ser 1 5 tct gat aaa cgt tct cct tca ctg tta gac gcc tcc tcc gag gtc ttt 163 Ser Asp Lys Arg Ser Pro Ser Leu Leu Asp Ala Ser Ser Glu Val Phe 10 15 20 gtc cat gat ttg gca gct ttg tct ccc act gat gcc act gca tgg ggt 211 Val His Asp Leu Ala Ala Leu Ser Pro Thr Asp Ala Thr Ala Trp Gly 25 30 35 atc tca ggc ttc gaa ggt gat ctt cag gat ttc tct cct gac tat tgg 259 Ile Ser Gly Phe Glu Gly Asp Leu Gln Asp Phe Ser Pro Asp Tyr Trp 40 45 50 aat gcc atc gcc gaa cgc aac cgc gac atg gtt gcc gat gtt gat gct 307 Asn Ala Ile Ala Glu Arg Asn Arg Asp Met Val Ala Asp Val Asp Ala 55 60 65 ttt gat gac ggc act gat gac aac gat gac gaa gaa gat ttc gat gac 355 Phe Asp Asp Gly Thr Asp Asp Asn Asp Asp Glu Glu Asp Phe Asp Asp 70 75 80 85 gtt gac cgc gtc acc gct gat gtt ctc cgt gat cgc gta tgc ctg gat 403 Val Asp Arg Val Thr Ala Asp Val Leu Arg Asp Arg Val Cys Leu Asp 90 95 100 ctg gcc ctg cac cac cag ggc gaa acc tta gcg aat ctc aac aac att 451 Leu Ala Leu His His Gln Gly Glu Thr Leu Ala Asn Leu Asn Asn Ile 105 110 115 gat tcc cca gtc cag acc atc cgc gat acc ttc ctc atc atg ccc cgc 499 Asp Ser Pro Val Gln Thr Ile Arg Asp Thr Phe Leu Ile Met Pro Arg 120 125 130 gag acg gac gat gat gtg gaa aat ctc cgc gaa cgt ctc tcc cgc gtc 547 Glu Thr Asp Asp Asp Val Glu Asn Leu Arg Glu Arg Leu Ser Arg Val 135 140 145 ccc gac gct ctc cac gga tac tgt gaa tca ctc gct gag gct gcc agc 595 Pro Asp Ala Leu His Gly Tyr Cys Glu Ser Leu Ala Glu Ala Ala Ser 150 155 160 165 caa ggc cat gtt gca gcg gtc cgc cag gtg gaa gaa gtg gtg tcg caa 643 Gln Gly His Val Ala Ala Val Arg Gln Val Glu Glu Val Val Ser Gln 170 175 180 tgt gag gac ctc gct gat gag gac tcc gtt ttg cag cac ctt ggc ttg 691 Cys Glu Asp Leu Ala Asp Glu Asp Ser Val Leu Gln His Leu Gly Leu 185 190 195 gat gaa aat gat cca gta gtt gta gag gcc cag gaa gct ttt gca cga 739 Asp Glu Asn Asp Pro Val Val Val Glu Ala Gln Glu Ala Phe Ala Arg 200 205 210 gtt gcc ggt tgg tta gca gag caa ctg gct ccg cat gct cct cat gtg 787 Val Ala Gly Trp Leu Ala Glu Gln Leu Ala Pro His Ala Pro His Val 215 220 225 gat gcg gtt ggc cgg gat cgc tat gaa atg ttc tcc cac ctg cac gtc 835 Asp Ala Val Gly Arg Asp Arg Tyr Glu Met Phe Ser His Leu His Val 230 235 240 245 ggc gag ttt gta gat ctg gat gag gct tac caa tgg tcc ctg gaa cag 883 Gly Glu Phe Val Asp Leu Asp Glu Ala Tyr Gln Trp Ser Leu Glu Gln 250 255 260 ctg cgt gac att gat gct cag cag ctt cag gta gcc cag cag ctg tac 931 Leu Arg Asp Ile Asp Ala Gln Gln Leu Gln Val Ala Gln Gln Leu Tyr 265 270 275 ggc cct ggc acc acg atc cgt gag gcc atg aag aag ctc aat gct gat 979 Gly Pro Gly Thr Thr Ile Arg Glu Ala Met Lys Lys Leu Asn Ala Asp 280 285 290 gag cgc tac ctc atc cga ggc act gat gct ctg cag gag tgg atg caa 1027 Glu Arg Tyr Leu Ile Arg Gly Thr Asp Ala Leu Gln Glu Trp Met Gln 295 300 305 aag acc gct gat cag gca atc gct gat cta gat ggc gtt tcc ttc aac 1075 Lys Thr Ala Asp Gln Ala Ile Ala Asp Leu Asp Gly Val Ser Phe Asn 310 315 320 325 att cca gag cag gct cga cag gtt gag tgc ctc atc gat cct gct gga 1123 Ile Pro Glu Gln Ala Arg Gln Val Glu Cys Leu Ile Asp Pro Ala Gly 330 335 340 act ggc ggc att ttc tac acc cca cca agc gat gat ttc tcc agg cct 1171 Thr Gly Gly Ile Phe Tyr Thr Pro Pro Ser Asp Asp Phe Ser Arg Pro 345 350 355 ggc cgc atg tgg tgg tct gtg cct aaa acc cag gaa gtc ttc cac acc 1219 Gly Arg Met Trp Trp Ser Val Pro Lys Thr Gln Glu Val Phe His Thr 360 365 370 tgg caa gag ctc acc acc gtg ttc cac gag ggt gtt cct ggc cac cac 1267 Trp Gln Glu Leu Thr Thr Val Phe His Glu Gly Val Pro Gly His His 375 380 385 ctg cag atc tcc caa act ttg gtg gaa aag gat ctg aac ctg tgg cgt 1315 Leu Gln Ile Ser Gln Thr Leu Val Glu Lys Asp Leu Asn Leu Trp Arg 390 395 400 405 cga gtc gct tgc tgg aac tct ggc cac ggt gaa ggt tgg gcg ctg tac 1363 Arg Val Ala Cys Trp Asn Ser Gly His Gly Glu Gly Trp Ala Leu Tyr 410 415 420 gca gaa tct ctc atg aag gaa ttg gga tac cac gaa gat cca ggc aac 1411 Ala Glu Ser Leu Met Lys Glu Leu Gly Tyr His Glu Asp Pro Gly Asn 425 430 435 ctc atg ggc tac ctt gat gct cag cga ctc cgt gca gcc cgc gtg gcc 1459 Leu Met Gly Tyr Leu Asp Ala Gln Arg Leu Arg Ala Ala Arg Val Ala 440 445 450 att gac atc gga att cac ctg aac aag agg aac cca gag tgc acc ggc 1507 Ile Asp Ile Gly Ile His Leu Asn Lys Arg Asn Pro Glu Cys Thr Gly 455 460 465 ctg tgg gat gcg tct tat gcg cgc agc ttc ctg cgt gaa aat acg tcc 1555 Leu Trp Asp Ala Ser Tyr Ala Arg Ser Phe Leu Arg Glu Asn Thr Ser 470 475 480 485 atg aat gaa gat gcg ctg tac ttt gag ctc aac cgt tac ctt ggt tgg 1603 Met Asn Glu Asp Ala Leu Tyr Phe Glu Leu Asn Arg Tyr Leu Gly Trp 490 495 500 cca ggt cag gcc gca tcg tat gcc att ggt cag cga ctc tgg ttg aac 1651 Pro Gly Gln Ala Ala Ser Tyr Ala Ile Gly Gln Arg Leu Trp Leu Asn 505 510 515 ctg cgc gat gag gcc att agc cag ggg caa acc ttg gcg caa ttc cac 1699 Leu Arg Asp Glu Ala Ile Ser Gln Gly Gln Thr Leu Ala Gln Phe His 520 525 530 agc aag gca ttg tcc tat ggc agc atc ccg atg ggc att ttg cgc gat 1747 Ser Lys Ala Leu Ser Tyr Gly Ser Ile Pro Met Gly Ile Leu Arg Asp 535 540 545 cag gtg ctg aac tagaaggcct ttaacgatcc ctacgcaaaa 1789 Gln Val Leu Asn 550 <210> 280 <211> 553 <212> PRT <213> Corynebacterium glutamicum <400> 280 Met Thr Leu Gln Ser Ser Asp Lys Arg Ser Pro Ser Leu Leu Asp Ala 1 5 10 15 Ser Ser Glu Val Phe Val His Asp Leu Ala Ala Leu Ser Pro Thr Asp 20 25 30 Ala Thr Ala Trp Gly Ile Ser Gly Phe Glu Gly Asp Leu Gln Asp Phe 35 40 45 Ser Pro Asp Tyr Trp Asn Ala Ile Ala Glu Arg Asn Arg Asp Met Val 50 55 60 Ala Asp Val Asp Ala Phe Asp Asp Gly Thr Asp Asp Asn Asp Asp Glu 65 70 75 80 Glu Asp Phe Asp Asp Val Asp Arg Val Thr Ala Asp Val Leu Arg Asp 85 90 95 Arg Val Cys Leu Asp Leu Ala Leu His His Gln Gly Glu Thr Leu Ala 100 105 110 Asn Leu Asn Asn Ile Asp Ser Pro Val Gln Thr Ile Arg Asp Thr Phe 115 120 125 Leu Ile Met Pro Arg Glu Thr Asp Asp Asp Val Glu Asn Leu Arg Glu 130 135 140 Arg Leu Ser Arg Val Pro Asp Ala Leu His Gly Tyr Cys Glu Ser Leu 145 150 155 160 Ala Glu Ala Ala Ser Gln Gly His Val Ala Ala Val Arg Gln Val Glu 165 170 175 Glu Val Val Ser Gln Cys Glu Asp Leu Ala Asp Glu Asp Ser Val Leu 180 185 190 Gln His Leu Gly Leu Asp Glu Asn Asp Pro Val Val Val Glu Ala Gln 195 200 205 Glu Ala Phe Ala Arg Val Ala Gly Trp Leu Ala Glu Gln Leu Ala Pro 210 215 220 His Ala Pro His Val Asp Ala Val Gly Arg Asp Arg Tyr Glu Met Phe 225 230 235 240 Ser His Leu His Val Gly Glu Phe Val Asp Leu Asp Glu Ala Tyr Gln 245 250 255 Trp Ser Leu Glu Gln Leu Arg Asp Ile Asp Ala Gln Gln Leu Gln Val 260 265 270 Ala Gln Gln Leu Tyr Gly Pro Gly Thr Thr Ile Arg Glu Ala Met Lys 275 280 285 Lys Leu Asn Ala Asp Glu Arg Tyr Leu Ile Arg Gly Thr Asp Ala Leu 290 295 300 Gln Glu Trp Met Gln Lys Thr Ala Asp Gln Ala Ile Ala Asp Leu Asp 305 310 315 320 Gly Val Ser Phe Asn Ile Pro Glu Gln Ala Arg Gln Val Glu Cys Leu 325 330 335 Ile Asp Pro Ala Gly Thr Gly Gly Ile Phe Tyr Thr Pro Pro Ser Asp 340 345 350 Asp Phe Ser Arg Pro Gly Arg Met Trp Trp Ser Val Pro Lys Thr Gln 355 360 365 Glu Val Phe His Thr Trp Gln Glu Leu Thr Thr Val Phe His Glu Gly 370 375 380 Val Pro Gly His His Leu Gln Ile Ser Gln Thr Leu Val Glu Lys Asp 385 390 395 400 Leu Asn Leu Trp Arg Arg Val Ala Cys Trp Asn Ser Gly His Gly Glu 405 410 415 Gly Trp Ala Leu Tyr Ala Glu Ser Leu Met Lys Glu Leu Gly Tyr His 420 425 430 Glu Asp Pro Gly Asn Leu Met Gly Tyr Leu Asp Ala Gln Arg Leu Arg 435 440 445 Ala Ala Arg Val Ala Ile Asp Ile Gly Ile His Leu Asn Lys Arg Asn 450 455 460 Pro Glu Cys Thr Gly Leu Trp Asp Ala Ser Tyr Ala Arg Ser Phe Leu 465 470 475 480 Arg Glu Asn Thr Ser Met Asn Glu Asp Ala Leu Tyr Phe Glu Leu Asn 485 490 495 Arg Tyr Leu Gly Trp Pro Gly Gln Ala Ala Ser Tyr Ala Ile Gly Gln 500 505 510 Arg Leu Trp Leu Asn Leu Arg Asp Glu Ala Ile Ser Gln Gly Gln Thr 515 520 525 Leu Ala Gln Phe His Ser Lys Ala Leu Ser Tyr Gly Ser Ile Pro Met 530 535 540 Gly Ile Leu Arg Asp Gln Val Leu Asn 545 550 <210> 281 <211> 1009 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(979) <223> RXA02302 <400> 281 ggccaggttc ggttagtgcg cgatctccct gatctctgac tcatacatcc aataagatcc 60 agacatatgc gaagctaatg aaggaaacga ggagctgata gtg gca aca aat cgt 115 Val Ala Thr Asn Arg 1 5 aca tct tcc gct ggt gtc atc acg tct gtt ctc gca tcc gct ttg ttc 163 Thr Ser Ser Ala Gly Val Ile Thr Ser Val Leu Ala Ser Ala Leu Phe 10 15 20 gga gcg atc ttt ttc atc tct ggg gcg att gag gca aag gcg gaa aca 211 Gly Ala Ile Phe Phe Ile Ser Gly Ala Ile Glu Ala Lys Ala Glu Thr 25 30 35 ctt gtt gct tgg cgt gtc ctt cta aca gcg gca tgc tat ttg ctt gcc 259 Leu Val Ala Trp Arg Val Leu Leu Thr Ala Ala Cys Tyr Leu Leu Ala 40 45 50 ctt ctg cac cct gct ggt cgg aag gtg ttt aag gaa ttt tgg gac aca 307 Leu Leu His Pro Ala Gly Arg Lys Val Phe Lys Glu Phe Trp Asp Thr 55 60 65 cta agg tcc caa cct cgt caa att ctg tac ttt atc ttc ctc gtt gta 355 Leu Arg Ser Gln Pro Arg Gln Ile Leu Tyr Phe Ile Phe Leu Val Val 70 75 80 85 ctc atc acg ctt cag ctg tgg ctg ttt tct tgg tcg cct aag agt cat 403 Leu Ile Thr Leu Gln Leu Trp Leu Phe Ser Trp Ser Pro Lys Ser His 90 95 100 gct tta gat gcc tca ctt ggt tac ctg tta ctg ccc att ttc cta gta 451 Ala Leu Asp Ala Ser Leu Gly Tyr Leu Leu Leu Pro Ile Phe Leu Val 105 110 115 att gtg ggg cgg ttt ttc ttc gct gat tac atc acc agg ctg cag tgg 499 Ile Val Gly Arg Phe Phe Phe Ala Asp Tyr Ile Thr Arg Leu Gln Trp 120 125 130 att gcg gtg gga atc gcg ctg atc gca gta acc ttg aaa ttt gtc att 547 Ile Ala Val Gly Ile Ala Leu Ile Ala Val Thr Leu Lys Phe Val Ile 135 140 145 agt gcg caa tta tcg tgg gta act ttt gcc atc gct gcg ggt tat gca 595 Ser Ala Gln Leu Ser Trp Val Thr Phe Ala Ile Ala Ala Gly Tyr Ala 150 155 160 165 ctg tat ttt gcg ctt cgt aaa tac tcg ggg ctg aac aac gct ttt gct 643 Leu Tyr Phe Ala Leu Arg Lys Tyr Ser Gly Leu Asn Asn Ala Phe Ala 170 175 180 tac ggc gca gaa gtt tta gcg tta agt ccc ctg gca ttt ttc atg ctc 691 Tyr Gly Ala Glu Val Leu Ala Leu Ser Pro Leu Ala Phe Phe Met Leu 185 190 195 gcc act gtc gag gat ccg ctg tct aac gcc atg ttg tca atg gtt att 739 Ala Thr Val Glu Asp Pro Leu Ser Asn Ala Met Leu Ser Met Val Ile 200 205 210 ctg gcg ggc ctc gct ggc gca tta gct atg gcg ttg tat cta gcc gcc 787 Leu Ala Gly Leu Ala Gly Ala Leu Ala Met Ala Leu Tyr Leu Ala Ala 215 220 225 tca act ctg ctt agt atg ccg atg ttt ggc ctg ctc agt tat ggt gaa 835 Ser Thr Leu Leu Ser Met Pro Met Phe Gly Leu Leu Ser Tyr Gly Glu 230 235 240 245 cca atc ttg ctg ttt gtt gca gca cta tta ctt ggt gaa acg ttg aat 883 Pro Ile Leu Leu Phe Val Ala Ala Leu Leu Leu Gly Glu Thr Leu Asn 250 255 260 ctc agc gac gcc att gtc tac tca cta ctg gcg tgc gcc ctg gcg tta 931 Leu Ser Asp Ala Ile Val Tyr Ser Leu Leu Ala Cys Ala Leu Ala Leu 265 270 275 ctg gga ttt gat ggg ata cga agg tct cga aaa aac ctc gag acc gat 979 Leu Gly Phe Asp Gly Ile Arg Arg Ser Arg Lys Asn Leu Glu Thr Asp 280 285 290 taacttctgc tcaacttccc accaattaag 1009 <210> 282 <211> 293 <212> PRT <213> Corynebacterium glutamicum <400> 282 Val Ala Thr Asn Arg Thr Ser Ser Ala Gly Val Ile Thr Ser Val Leu 1 5 10 15 Ala Ser Ala Leu Phe Gly Ala Ile Phe Phe Ile Ser Gly Ala Ile Glu 20 25 30 Ala Lys Ala Glu Thr Leu Val Ala Trp Arg Val Leu Leu Thr Ala Ala 35 40 45 Cys Tyr Leu Leu Ala Leu Leu His Pro Ala Gly Arg Lys Val Phe Lys 50 55 60 Glu Phe Trp Asp Thr Leu Arg Ser Gln Pro Arg Gln Ile Leu Tyr Phe 65 70 75 80 Ile Phe Leu Val Val Leu Ile Thr Leu Gln Leu Trp Leu Phe Ser Trp 85 90 95 Ser Pro Lys Ser His Ala Leu Asp Ala Ser Leu Gly Tyr Leu Leu Leu 100 105 110 Pro Ile Phe Leu Val Ile Val Gly Arg Phe Phe Phe Ala Asp Tyr Ile 115 120 125 Thr Arg Leu Gln Trp Ile Ala Val Gly Ile Ala Leu Ile Ala Val Thr 130 135 140 Leu Lys Phe Val Ile Ser Ala Gln Leu Ser Trp Val Thr Phe Ala Ile 145 150 155 160 Ala Ala Gly Tyr Ala Leu Tyr Phe Ala Leu Arg Lys Tyr Ser Gly Leu 165 170 175 Asn Asn Ala Phe Ala Tyr Gly Ala Glu Val Leu Ala Leu Ser Pro Leu 180 185 190 Ala Phe Phe Met Leu Ala Thr Val Glu Asp Pro Leu Ser Asn Ala Met 195 200 205 Leu Ser Met Val Ile Leu Ala Gly Leu Ala Gly Ala Leu Ala Met Ala 210 215 220 Leu Tyr Leu Ala Ala Ser Thr Leu Leu Ser Met Pro Met Phe Gly Leu 225 230 235 240 Leu Ser Tyr Gly Glu Pro Ile Leu Leu Phe Val Ala Ala Leu Leu Leu 245 250 255 Gly Glu Thr Leu Asn Leu Ser Asp Ala Ile Val Tyr Ser Leu Leu Ala 260 265 270 Cys Ala Leu Ala Leu Leu Gly Phe Asp Gly Ile Arg Arg Ser Arg Lys 275 280 285 Asn Leu Glu Thr Asp 290 <210> 283 <211> 1036 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1006) <223> RXA02303 <400> 283 gcccgggccg aaatcattcc aatctcaccc ccacccaaaa cactgttgat attttcactt 60 tccaaccagc gacgtgagcg cacgcactaa ggttgtgccc atg gct gaa aac aac 115 Met Ala Glu Asn Asn 1 5 acc cca caa gaa act gaa caa gat cag gaa gca cgc ttc cgt gag gag 163 Thr Pro Gln Glu Thr Glu Gln Asp Gln Glu Ala Arg Phe Arg Glu Glu 10 15 20 ttc gag gtt ggc ggt aag gat cgt cag ctt tct gaa gaa gaa cag ctg 211 Phe Glu Val Gly Gly Lys Asp Arg Gln Leu Ser Glu Glu Glu Gln Leu 25 30 35 gag cag ctc gga tcg tat att gat gcg cac tac cct gtt cca gat ttc 259 Glu Gln Leu Gly Ser Tyr Ile Asp Ala His Tyr Pro Val Pro Asp Phe 40 45 50 acg ccc cct tgg gca ggt ggc gcc ggc gat cct gat cca gca gac cgc 307 Thr Pro Pro Trp Ala Gly Gly Ala Gly Asp Pro Asp Pro Ala Asp Arg 55 60 65 tat att gca cat ctt ccc gat cgc acc acg cat act gcg atg atc atg 355 Tyr Ile Ala His Leu Pro Asp Arg Thr Thr His Thr Ala Met Ile Met 70 75 80 85 ttg ggt tct ggc ctt gat cat tcc atg ccg ggt gtc gca ttt atc ggt 403 Leu Gly Ser Gly Leu Asp His Ser Met Pro Gly Val Ala Phe Ile Gly 90 95 100 ggt gtg agc gtc gat gac gtc ccg gag gtc gga ggc gcg att ttc cac 451 Gly Val Ser Val Asp Asp Val Pro Glu Val Gly Gly Ala Ile Phe His 105 110 115 ccg tcg aat ccg acg ggc cgc tgg gct gta tcg ttc cac agc ggt ggt 499 Pro Ser Asn Pro Thr Gly Arg Trp Ala Val Ser Phe His Ser Gly Gly 120 125 130 tgg tgg cgc ggt tcc ggt gat gcg ttg gag ttc cag tgg cgt cca gag 547 Trp Trp Arg Gly Ser Gly Asp Ala Leu Glu Phe Gln Trp Arg Pro Glu 135 140 145 gtc gcg gca gct gcg gaa ttg tcc ggc aca acc atc ctt gac ctg gac 595 Val Ala Ala Ala Ala Glu Leu Ser Gly Thr Thr Ile Leu Asp Leu Asp 150 155 160 165 tat ccg ctg gcc cca ggc cat aac ctc cac gat atg aat gag gtt gtg 643 Tyr Pro Leu Ala Pro Gly His Asn Leu His Asp Met Asn Glu Val Val 170 175 180 ggc aag gcg gtc ggt tac gcc cgc cac cat aat ccg gtg tcg atc acg 691 Gly Lys Ala Val Gly Tyr Ala Arg His His Asn Pro Val Ser Ile Thr 185 190 195 ggt tgg ggt tat tcc tcg ggc gcg gcg tta gcc gcg att aat gca tcg 739 Gly Trp Gly Tyr Ser Ser Gly Ala Ala Leu Ala Ala Ile Asn Ala Ser 200 205 210 ctt ttc gac gcc ctg gtc ctc acc ttt ccg gac ctg ggt agc gtc gag 787 Leu Phe Asp Ala Leu Val Leu Thr Phe Pro Asp Leu Gly Ser Val Glu 215 220 225 aag ctc cct gcc gaa att cgt gga gac gct gta gtg ccc gcg gcg gct 835 Lys Leu Pro Ala Glu Ile Arg Gly Asp Ala Val Val Pro Ala Ala Ala 230 235 240 245 gcg tgg ccg acg acc ttt gtg cag atc gcg gcg cag gat gag atc gcg 883 Ala Trp Pro Thr Thr Phe Val Gln Ile Ala Ala Gln Asp Glu Ile Ala 250 255 260 gag cgg cca gga gag ctt ggc gac gcg acc gtg aag gaa tac gtt tcc 931 Glu Arg Pro Gly Glu Leu Gly Asp Ala Thr Val Lys Glu Tyr Val Ser 265 270 275 cgc cac cgt att tcc aca ccg aag gtc gcg cgc gaa aaa atc acc gac 979 Arg His Arg Ile Ser Thr Pro Lys Val Ala Arg Glu Lys Ile Thr Asp 280 285 290 gtg gcg gag ttc ctt aaa act gtt tgc taatgtgcca gcaggttgta 1026 Val Ala Glu Phe Leu Lys Thr Val Cys 295 300 aataaacgct 1036 <210> 284 <211> 302 <212> PRT <213> Corynebacterium glutamicum <400> 284 Met Ala Glu Asn Asn Thr Pro Gln Glu Thr Glu Gln Asp Gln Glu Ala 1 5 10 15 Arg Phe Arg Glu Glu Phe Glu Val Gly Gly Lys Asp Arg Gln Leu Ser 20 25 30 Glu Glu Glu Gln Leu Glu Gln Leu Gly Ser Tyr Ile Asp Ala His Tyr 35 40 45 Pro Val Pro Asp Phe Thr Pro Pro Trp Ala Gly Gly Ala Gly Asp Pro 50 55 60 Asp Pro Ala Asp Arg Tyr Ile Ala His Leu Pro Asp Arg Thr Thr His 65 70 75 80 Thr Ala Met Ile Met Leu Gly Ser Gly Leu Asp His Ser Met Pro Gly 85 90 95 Val Ala Phe Ile Gly Gly Val Ser Val Asp Asp Val Pro Glu Val Gly 100 105 110 Gly Ala Ile Phe His Pro Ser Asn Pro Thr Gly Arg Trp Ala Val Ser 115 120 125 Phe His Ser Gly Gly Trp Trp Arg Gly Ser Gly Asp Ala Leu Glu Phe 130 135 140 Gln Trp Arg Pro Glu Val Ala Ala Ala Ala Glu Leu Ser Gly Thr Thr 145 150 155 160 Ile Leu Asp Leu Asp Tyr Pro Leu Ala Pro Gly His Asn Leu His Asp 165 170 175 Met Asn Glu Val Val Gly Lys Ala Val Gly Tyr Ala Arg His His Asn 180 185 190 Pro Val Ser Ile Thr Gly Trp Gly Tyr Ser Ser Gly Ala Ala Leu Ala 195 200 205 Ala Ile Asn Ala Ser Leu Phe Asp Ala Leu Val Leu Thr Phe Pro Asp 210 215 220 Leu Gly Ser Val Glu Lys Leu Pro Ala Glu Ile Arg Gly Asp Ala Val 225 230 235 240 Val Pro Ala Ala Ala Ala Trp Pro Thr Thr Phe Val Gln Ile Ala Ala 245 250 255 Gln Asp Glu Ile Ala Glu Arg Pro Gly Glu Leu Gly Asp Ala Thr Val 260 265 270 Lys Glu Tyr Val Ser Arg His Arg Ile Ser Thr Pro Lys Val Ala Arg 275 280 285 Glu Lys Ile Thr Asp Val Ala Glu Phe Leu Lys Thr Val Cys 290 295 300 <210> 285 <211> 544 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(514) <223> RXA02339 <400> 285 ttgagaaagc cctctcgccg ttcccaccga caacctcttt tcatatcctg cacaacgcta 60 tgatcttctc acacttgcct ttgaagttag gattggggac atg gtt caa att aat 115 Met Val Gln Ile Asn 1 5 gac atg ctt gcc cct cct cca gta aaa ctt ccg gaa gat cct gcc ctc 163 Asp Met Leu Ala Pro Pro Pro Val Lys Leu Pro Glu Asp Pro Ala Leu 10 15 20 ggc gcc gat cca act ttg acc tcg aca gcg att gcg cat cct gac agc 211 Gly Ala Asp Pro Thr Leu Thr Ser Thr Ala Ile Ala His Pro Asp Ser 25 30 35 cca ttg gtg tgg gcg tac cga gct gaa aat ctt atc aaa tct gca tca 259 Pro Leu Val Trp Ala Tyr Arg Ala Glu Asn Leu Ile Lys Ser Ala Ser 40 45 50 aat gat gaa gag aag att cag gcc tac gct ttt gcg cgc acg ggt tac 307 Asn Asp Glu Glu Lys Ile Gln Ala Tyr Ala Phe Ala Arg Thr Gly Tyr 55 60 65 cac cgc agt ctc gat cgt ctg cgt gcc aat ggt tgg aag ggt tgg ggt 355 His Arg Ser Leu Asp Arg Leu Arg Ala Asn Gly Trp Lys Gly Trp Gly 70 75 80 85 cct gtc ccc ttc tct cat gag cca aac cag gga gtg ttg cgg gct atc 403 Pro Val Pro Phe Ser His Glu Pro Asn Gln Gly Val Leu Arg Ala Ile 90 95 100 gct tcc cta gct ctt gct gcg aag ctg att ggt gag gac aac gaa tac 451 Ala Ser Leu Ala Leu Ala Ala Lys Leu Ile Gly Glu Asp Asn Glu Tyr 105 110 115 gat cgt tgc cgc cag atg ctc tct gat gcg gat cca gag tcc gtc gca 499 Asp Arg Cys Arg Gln Met Leu Ser Asp Ala Asp Pro Glu Ser Val Ala 120 125 130 gtc cta ctc gac aaa taaaccacca aaaataaaac aatctccctc 544 Val Leu Leu Asp Lys 135 <210> 286 <211> 138 <212> PRT <213> Corynebacterium glutamicum <400> 286 Met Val Gln Ile Asn Asp Met Leu Ala Pro Pro Pro Val Lys Leu Pro 1 5 10 15 Glu Asp Pro Ala Leu Gly Ala Asp Pro Thr Leu Thr Ser Thr Ala Ile 20 25 30 Ala His Pro Asp Ser Pro Leu Val Trp Ala Tyr Arg Ala Glu Asn Leu 35 40 45 Ile Lys Ser Ala Ser Asn Asp Glu Glu Lys Ile Gln Ala Tyr Ala Phe 50 55 60 Ala Arg Thr Gly Tyr His Arg Ser Leu Asp Arg Leu Arg Ala Asn Gly 65 70 75 80 Trp Lys Gly Trp Gly Pro Val Pro Phe Ser His Glu Pro Asn Gln Gly 85 90 95 Val Leu Arg Ala Ile Ala Ser Leu Ala Leu Ala Ala Lys Leu Ile Gly 100 105 110 Glu Asp Asn Glu Tyr Asp Arg Cys Arg Gln Met Leu Ser Asp Ala Asp 115 120 125 Pro Glu Ser Val Ala Val Leu Leu Asp Lys 130 135 <210> 287 <211> 2563 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2533) <223> RXA02360 <400> 287 aagtaactaa agttcgaaag tatttccgaa cggtgtcggc ctctgcgcat acactgtatt 60 tttaaagaaa attcttctca attctaaggg tgaatatcca atg cgt ggt gac gtt 115 Met Arg Gly Asp Val 1 5 caa aaa ata acc aag gtt tat gac ggc aag cac cga acc ttg gaa atc 163 Gln Lys Ile Thr Lys Val Tyr Asp Gly Lys His Arg Thr Leu Glu Ile 10 15 20 ccg gtt tat caa cgc aat tac gac tgg act gaa aag caa tgt tca cgc 211 Pro Val Tyr Gln Arg Asn Tyr Asp Trp Thr Glu Lys Gln Cys Ser Arg 25 30 35 ctc ttt gat gac ctc agc gaa gtg gtc aaa gaa aac cac cgt caa cat 259 Leu Phe Asp Asp Leu Ser Glu Val Val Lys Glu Asn His Arg Gln His 40 45 50 ttt ttt gga gct gtg gtt ggt aag cct caa ggc agc tgg acc tgg gtt 307 Phe Phe Gly Ala Val Val Gly Lys Pro Gln Gly Ser Trp Thr Trp Val 55 60 65 gtc atc gat gga cag cag cgt ctt aca aca atc agc ttg ttc atg ctt 355 Val Ile Asp Gly Gln Gln Arg Leu Thr Thr Ile Ser Leu Phe Met Leu 70 75 80 85 gcg ctg gta cat tcc ttg cgc gca tct gaa gtt gaa gaa ggt gag ttt 403 Ala Leu Val His Ser Leu Arg Ala Ser Glu Val Glu Glu Gly Glu Phe 90 95 100 aat gct ggc tac aac att gat cta gcc aca ttg att gag gat gac tac 451 Asn Ala Gly Tyr Asn Ile Asp Leu Ala Thr Leu Ile Glu Asp Asp Tyr 105 110 115 ctc cga tcc ggc aat gag gga aac ctc aag ttc aag ctc aag cca gtt 499 Leu Arg Ser Gly Asn Glu Gly Asn Leu Lys Phe Lys Leu Lys Pro Val 120 125 130 aaa aac gat aat gag gct tat caa aag ctc ttc ggc cca gaa tct gaa 547 Lys Asn Asp Asn Glu Ala Tyr Gln Lys Leu Phe Gly Pro Glu Ser Glu 135 140 145 ttc ata gag tcc tca aac ctc act gct aat tat cgc tac ttc cgc aat 595 Phe Ile Glu Ser Ser Asn Leu Thr Ala Asn Tyr Arg Tyr Phe Arg Asn 150 155 160 165 gtc ctt aag gca acc gat ctc acc gca gct caa cta tgg gaa gct atc 643 Val Leu Lys Ala Thr Asp Leu Thr Ala Ala Gln Leu Trp Glu Ala Ile 170 175 180 gag aaa ctc agg gtc atg tat ctt gac ctt gag gaa ttt gat gat ccg 691 Glu Lys Leu Arg Val Met Tyr Leu Asp Leu Glu Glu Phe Asp Asp Pro 185 190 195 cag cga atc ttt gaa agt ctc aac tcc acg gga tta gag ctc agt gaa 739 Gln Arg Ile Phe Glu Ser Leu Asn Ser Thr Gly Leu Glu Leu Ser Glu 200 205 210 gct gat aag gta cgc aac ttg gtt ctt atg gat cag gag ctc aaa acc 787 Ala Asp Lys Val Arg Asn Leu Val Leu Met Asp Gln Glu Leu Lys Thr 215 220 225 caa gaa aag ctc tat gag cag cgt tgg aat ccc att gaa gtc tgc gtg 835 Gln Glu Lys Leu Tyr Glu Gln Arg Trp Asn Pro Ile Glu Val Cys Val 230 235 240 245 aaa ttt gat acc gac aat ttc att cgc tgg tac tta act ctc aaa acc 883 Lys Phe Asp Thr Asp Asn Phe Ile Arg Trp Tyr Leu Thr Leu Lys Thr 250 255 260 gcg cgc acc cca aga aag caa gat gtt tat gag gaa ttc aag aaa ttc 931 Ala Arg Thr Pro Arg Lys Gln Asp Val Tyr Glu Glu Phe Lys Lys Phe 265 270 275 atc cgt aac tcc aag ctc ccg gtc gaa ttc atc ctc gac gat atg tac 979 Ile Arg Asn Ser Lys Leu Pro Val Glu Phe Ile Leu Asp Asp Met Tyr 280 285 290 gag tac gcg aag ctg tac cga gat ctc tta ggt gcc act act ggg ttt 1027 Glu Tyr Ala Lys Leu Tyr Arg Asp Leu Leu Gly Ala Thr Thr Gly Phe 295 300 305 ata gct gcc gat agg tgt ctt aag cgt ttt gtc cct gtc atg ggc gat 1075 Ile Ala Ala Asp Arg Cys Leu Lys Arg Phe Val Pro Val Met Gly Asp 310 315 320 325 gtg gtt ttg cct ttt ctg ctg cct gtt ctc aaa gat gct aaa gac ggc 1123 Val Val Leu Pro Phe Leu Leu Pro Val Leu Lys Asp Ala Lys Asp Gly 330 335 340 atc atc acc gaa tca gac ttc ctc gga gtt cta aaa gtt ctg gaa tcc 1171 Ile Ile Thr Glu Ser Asp Phe Leu Gly Val Leu Lys Val Leu Glu Ser 345 350 355 tat tta ttc cgc cgt ttt gca gtc ggg gtt gct agt aac gcc tta agc 1219 Tyr Leu Phe Arg Arg Phe Ala Val Gly Val Ala Ser Asn Ala Leu Ser 360 365 370 aag atc ttc tcc act gct tat agc gac atc aag aaa ttc tgg act cca 1267 Lys Ile Phe Ser Thr Ala Tyr Ser Asp Ile Lys Lys Phe Trp Thr Pro 375 380 385 ggg caa agt tat agc tca ctg ctg gcc tac att ctg aaa cgt cgc gat 1315 Gly Gln Ser Tyr Ser Ser Leu Leu Ala Tyr Ile Leu Lys Arg Arg Asp 390 395 400 405 ggt tcc ggg cgt ttt ccc tcc gac agt gaa ttc cgt gag aac ttc gca 1363 Gly Ser Gly Arg Phe Pro Ser Asp Ser Glu Phe Arg Glu Asn Phe Ala 410 415 420 acc aaa aat ttc tgg aat att cat aac gaa aac agg cgt tac tta ttt 1411 Thr Lys Asn Phe Trp Asn Ile His Asn Glu Asn Arg Arg Tyr Leu Phe 425 430 435 gat tgt cta gaa aat gcc gat tcc aat gat gtt cgt gac atc caa aca 1459 Asp Cys Leu Glu Asn Ala Asp Ser Asn Asp Val Arg Asp Ile Gln Thr 440 445 450 agt ctg gat gaa gga tct ctc tcc att gaa cac atc atg cca cgt agc 1507 Ser Leu Asp Glu Gly Ser Leu Ser Ile Glu His Ile Met Pro Arg Ser 455 460 465 cta aac gat cag tgg aga gct gaa ctc ggc cct gaa tat gct cga att 1555 Leu Asn Asp Gln Trp Arg Ala Glu Leu Gly Pro Glu Tyr Ala Arg Ile 470 475 480 485 cat gag act tgg att aat aga att ggt aac ctc acc atc acc ggc tac 1603 His Glu Thr Trp Ile Asn Arg Ile Gly Asn Leu Thr Ile Thr Gly Tyr 490 495 500 aac tcc gcc tat tca aat tct tcc tat gag cgc aag cgg acg atg gaa 1651 Asn Ser Ala Tyr Ser Asn Ser Ser Tyr Glu Arg Lys Arg Thr Met Glu 505 510 515 aat gga ttt ttg gta tcc ccc tat cgc atc aat aat ttc atc aaa aag 1699 Asn Gly Phe Leu Val Ser Pro Tyr Arg Ile Asn Asn Phe Ile Lys Lys 520 525 530 cag aag cat tgg tct gaa gaa cag cta att gag cga acc gag ctg ctc 1747 Gln Lys His Trp Ser Glu Glu Gln Leu Ile Glu Arg Thr Glu Leu Leu 535 540 545 act caa gca gcg ctg gac tac tgg ccc ctt cca aaa gaa acc ttc cag 1795 Thr Gln Ala Ala Leu Asp Tyr Trp Pro Leu Pro Lys Glu Thr Phe Gln 550 555 560 565 cca cca caa gct gtg ctt cct aca gaa tcc tta gat agt gat ctt tct 1843 Pro Pro Gln Ala Val Leu Pro Thr Glu Ser Leu Asp Ser Asp Leu Ser 570 575 580 ttc cgc gga cgc gaa att gtc gcc ttt gaa tat gag gac tac aag gaa 1891 Phe Arg Gly Arg Glu Ile Val Ala Phe Glu Tyr Glu Asp Tyr Lys Glu 585 590 595 acg gta acg tcc tgg gca gac atg ctc cag agc gtt cta aaa gtc ttg 1939 Thr Val Thr Ser Trp Ala Asp Met Leu Gln Ser Val Leu Lys Val Leu 600 605 610 aac caa tcc ttc cgc cag gaa ctc ata gct ttg acc aat gaa gaa atc 1987 Asn Gln Ser Phe Arg Gln Glu Leu Ile Ala Leu Thr Asn Glu Glu Ile 615 620 625 tgc ctg gca act tca aac aac agt aac agc agt ctc cgt gaa att gac 2035 Cys Leu Ala Thr Ser Asn Asn Ser Asn Ser Ser Leu Arg Glu Ile Asp 630 635 640 645 cac ggg ctt ttt gta gac act ggc tct agt acg agt gta aag att ggc 2083 His Gly Leu Phe Val Asp Thr Gly Ser Ser Thr Ser Val Lys Ile Gly 650 655 660 ttc ctc cgc aga gtt ttt act caa ctg ggg cta gag cag gaa gca ttg 2131 Phe Leu Arg Arg Val Phe Thr Gln Leu Gly Leu Glu Gln Glu Ala Leu 665 670 675 gtt ttc acc ctt cga cca ctg gca aat gat gta gaa ccc cga gat gat 2179 Val Phe Thr Leu Arg Pro Leu Ala Asn Asp Val Glu Pro Arg Asp Asp 680 685 690 gaa ctc gag gta gag gta gaa aag aaa tat tcc gat ttg act aaa ttc 2227 Glu Leu Glu Val Glu Val Glu Lys Lys Tyr Ser Asp Leu Thr Lys Phe 695 700 705 atc cca cag tta gaa gaa gct gag aat ctc gag ggg gcg gat aca gag 2275 Ile Pro Gln Leu Glu Glu Ala Glu Asn Leu Glu Gly Ala Asp Thr Glu 710 715 720 725 gtt att cct ctc ctc tca aag ctc aag gaa caa ctg aca gcc ttt agc 2323 Val Ile Pro Leu Leu Ser Lys Leu Lys Glu Gln Leu Thr Ala Phe Ser 730 735 740 ccg gag aat cct caa gca gcc cta ggg ggc cta cct gtt cca gaa ttc 2371 Pro Glu Asn Pro Gln Ala Ala Leu Gly Gly Leu Pro Val Pro Glu Phe 745 750 755 ctc aaa caa aat gtg att gaa caa cta agc gca gag cac atc ctt gct 2419 Leu Lys Gln Asn Val Ile Glu Gln Leu Ser Ala Glu His Ile Leu Ala 760 765 770 gta ctc act caa cac ttt aat atc gca tcc atg atg ggt gat gac tat 2467 Val Leu Thr Gln His Phe Asn Ile Ala Ser Met Met Gly Asp Asp Tyr 775 780 785 ttg ctc gaa gag ctc agg tca ggc cgc tta agg gaa tta ctg cag cgt 2515 Leu Leu Glu Glu Leu Arg Ser Gly Arg Leu Arg Glu Leu Leu Gln Arg 790 795 800 805 tta gag gaa ttg gat agc taatagccgt agtcggtggt caaactttga 2563 Leu Glu Glu Leu Asp Ser 810 <210> 288 <211> 811 <212> PRT <213> Corynebacterium glutamicum <400> 288 Met Arg Gly Asp Val Gln Lys Ile Thr Lys Val Tyr Asp Gly Lys His 1 5 10 15 Arg Thr Leu Glu Ile Pro Val Tyr Gln Arg Asn Tyr Asp Trp Thr Glu 20 25 30 Lys Gln Cys Ser Arg Leu Phe Asp Asp Leu Ser Glu Val Val Lys Glu 35 40 45 Asn His Arg Gln His Phe Phe Gly Ala Val Val Gly Lys Pro Gln Gly 50 55 60 Ser Trp Thr Trp Val Val Ile Asp Gly Gln Gln Arg Leu Thr Thr Ile 65 70 75 80 Ser Leu Phe Met Leu Ala Leu Val His Ser Leu Arg Ala Ser Glu Val 85 90 95 Glu Glu Gly Glu Phe Asn Ala Gly Tyr Asn Ile Asp Leu Ala Thr Leu 100 105 110 Ile Glu Asp Asp Tyr Leu Arg Ser Gly Asn Glu Gly Asn Leu Lys Phe 115 120 125 Lys Leu Lys Pro Val Lys Asn Asp Asn Glu Ala Tyr Gln Lys Leu Phe 130 135 140 Gly Pro Glu Ser Glu Phe Ile Glu Ser Ser Asn Leu Thr Ala Asn Tyr 145 150 155 160 Arg Tyr Phe Arg Asn Val Leu Lys Ala Thr Asp Leu Thr Ala Ala Gln 165 170 175 Leu Trp Glu Ala Ile Glu Lys Leu Arg Val Met Tyr Leu Asp Leu Glu 180 185 190 Glu Phe Asp Asp Pro Gln Arg Ile Phe Glu Ser Leu Asn Ser Thr Gly 195 200 205 Leu Glu Leu Ser Glu Ala Asp Lys Val Arg Asn Leu Val Leu Met Asp 210 215 220 Gln Glu Leu Lys Thr Gln Glu Lys Leu Tyr Glu Gln Arg Trp Asn Pro 225 230 235 240 Ile Glu Val Cys Val Lys Phe Asp Thr Asp Asn Phe Ile Arg Trp Tyr 245 250 255 Leu Thr Leu Lys Thr Ala Arg Thr Pro Arg Lys Gln Asp Val Tyr Glu 260 265 270 Glu Phe Lys Lys Phe Ile Arg Asn Ser Lys Leu Pro Val Glu Phe Ile 275 280 285 Leu Asp Asp Met Tyr Glu Tyr Ala Lys Leu Tyr Arg Asp Leu Leu Gly 290 295 300 Ala Thr Thr Gly Phe Ile Ala Ala Asp Arg Cys Leu Lys Arg Phe Val 305 310 315 320 Pro Val Met Gly Asp Val Val Leu Pro Phe Leu Leu Pro Val Leu Lys 325 330 335 Asp Ala Lys Asp Gly Ile Ile Thr Glu Ser Asp Phe Leu Gly Val Leu 340 345 350 Lys Val Leu Glu Ser Tyr Leu Phe Arg Arg Phe Ala Val Gly Val Ala 355 360 365 Ser Asn Ala Leu Ser Lys Ile Phe Ser Thr Ala Tyr Ser Asp Ile Lys 370 375 380 Lys Phe Trp Thr Pro Gly Gln Ser Tyr Ser Ser Leu Leu Ala Tyr Ile 385 390 395 400 Leu Lys Arg Arg Asp Gly Ser Gly Arg Phe Pro Ser Asp Ser Glu Phe 405 410 415 Arg Glu Asn Phe Ala Thr Lys Asn Phe Trp Asn Ile His Asn Glu Asn 420 425 430 Arg Arg Tyr Leu Phe Asp Cys Leu Glu Asn Ala Asp Ser Asn Asp Val 435 440 445 Arg Asp Ile Gln Thr Ser Leu Asp Glu Gly Ser Leu Ser Ile Glu His 450 455 460 Ile Met Pro Arg Ser Leu Asn Asp Gln Trp Arg Ala Glu Leu Gly Pro 465 470 475 480 Glu Tyr Ala Arg Ile His Glu Thr Trp Ile Asn Arg Ile Gly Asn Leu 485 490 495 Thr Ile Thr Gly Tyr Asn Ser Ala Tyr Ser Asn Ser Ser Tyr Glu Arg 500 505 510 Lys Arg Thr Met Glu Asn Gly Phe Leu Val Ser Pro Tyr Arg Ile Asn 515 520 525 Asn Phe Ile Lys Lys Gln Lys His Trp Ser Glu Glu Gln Leu Ile Glu 530 535 540 Arg Thr Glu Leu Leu Thr Gln Ala Ala Leu Asp Tyr Trp Pro Leu Pro 545 550 555 560 Lys Glu Thr Phe Gln Pro Pro Gln Ala Val Leu Pro Thr Glu Ser Leu 565 570 575 Asp Ser Asp Leu Ser Phe Arg Gly Arg Glu Ile Val Ala Phe Glu Tyr 580 585 590 Glu Asp Tyr Lys Glu Thr Val Thr Ser Trp Ala Asp Met Leu Gln Ser 595 600 605 Val Leu Lys Val Leu Asn Gln Ser Phe Arg Gln Glu Leu Ile Ala Leu 610 615 620 Thr Asn Glu Glu Ile Cys Leu Ala Thr Ser Asn Asn Ser Asn Ser Ser 625 630 635 640 Leu Arg Glu Ile Asp His Gly Leu Phe Val Asp Thr Gly Ser Ser Thr 645 650 655 Ser Val Lys Ile Gly Phe Leu Arg Arg Val Phe Thr Gln Leu Gly Leu 660 665 670 Glu Gln Glu Ala Leu Val Phe Thr Leu Arg Pro Leu Ala Asn Asp Val 675 680 685 Glu Pro Arg Asp Asp Glu Leu Glu Val Glu Val Glu Lys Lys Tyr Ser 690 695 700 Asp Leu Thr Lys Phe Ile Pro Gln Leu Glu Glu Ala Glu Asn Leu Glu 705 710 715 720 Gly Ala Asp Thr Glu Val Ile Pro Leu Leu Ser Lys Leu Lys Glu Gln 725 730 735 Leu Thr Ala Phe Ser Pro Glu Asn Pro Gln Ala Ala Leu Gly Gly Leu 740 745 750 Pro Val Pro Glu Phe Leu Lys Gln Asn Val Ile Glu Gln Leu Ser Ala 755 760 765 Glu His Ile Leu Ala Val Leu Thr Gln His Phe Asn Ile Ala Ser Met 770 775 780 Met Gly Asp Asp Tyr Leu Leu Glu Glu Leu Arg Ser Gly Arg Leu Arg 785 790 795 800 Glu Leu Leu Gln Arg Leu Glu Glu Leu Asp Ser 805 810 <210> 289 <211> 3829 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3799) <223> RXA02362 <400> 289 acaattgttc ccattcgcat atctcgtgtc caccagagtc gctacagtaa cgagaaactt 60 aattatttga tccgattctt ccgttcaaag gcctcattcc gtg act atc tct cgc 115 Val Thr Ile Ser Arg 1 5 cga ctc aaa caa gag cgc agt ttc gct gac gat ctt caa gat ctc aaa 163 Arg Leu Lys Gln Glu Arg Ser Phe Ala Asp Asp Leu Gln Asp Leu Lys 10 15 20 act ctc aat gat caa ctg cgg ttt aca aac gcc aaa ttg caa gct cgc 211 Thr Leu Asn Asp Gln Leu Arg Phe Thr Asn Ala Lys Leu Gln Ala Arg 25 30 35 atc agt ggt att ggc aat gat gga aag aaa atc acg cgc cct acc cca 259 Ile Ser Gly Ile Gly Asn Asp Gly Lys Lys Ile Thr Arg Pro Thr Pro 40 45 50 ctc ctt gcg ctg gat ttt cag ctg acc gtt gaa gaa tac gaa acg atc 307 Leu Leu Ala Leu Asp Phe Gln Leu Thr Val Glu Glu Tyr Glu Thr Ile 55 60 65 att gca atc ttg gtg gaa gca gtt ggc gga aat caa tcc aag cca gcg 355 Ile Ala Ile Leu Val Glu Ala Val Gly Gly Asn Gln Ser Lys Pro Ala 70 75 80 85 att ctt aaa gat ctg ttt ata gaa tat cca ctc gtc ttc ctg gca gcg 403 Ile Leu Lys Asp Leu Phe Ile Glu Tyr Pro Leu Val Phe Leu Ala Ala 90 95 100 ctt tct gga acc gcc atg ctc gat gct caa gaa ggt ttc tgg cct gcg 451 Leu Ser Gly Thr Ala Met Leu Asp Ala Gln Glu Gly Phe Trp Pro Ala 105 110 115 ttc tgg aaa cgc act cag gtg tca gtt cca gag cat gta tac gac gcg 499 Phe Trp Lys Arg Thr Gln Val Ser Val Pro Glu His Val Tyr Asp Ala 120 125 130 atc cgt aaa gaa cta gtt aat agc atc cgc aaa aat ggc cta gaa act 547 Ile Arg Lys Glu Leu Val Asn Ser Ile Arg Lys Asn Gly Leu Glu Thr 135 140 145 ttt tct ctc gct gac ctc aat cga cgc gaa tat gtc gga ctc atc caa 595 Phe Ser Leu Ala Asp Leu Asn Arg Arg Glu Tyr Val Gly Leu Ile Gln 150 155 160 165 ctt cac agt ggc ctt tct gca aaa gac atg ctc gcc ttg gtc aaa ttt 643 Leu His Ser Gly Leu Ser Ala Lys Asp Met Leu Ala Leu Val Lys Phe 170 175 180 atc gat cac act cga gca gaa aac caa gga tgg gat tct ggt gag gac 691 Ile Asp His Thr Arg Ala Glu Asn Gln Gly Trp Asp Ser Gly Glu Asp 185 190 195 ttt gca tca tat gcg aag agt gtc ttc tcc tcc ggg gac aac cta tta 739 Phe Ala Ser Tyr Ala Lys Ser Val Phe Ser Ser Gly Asp Asn Leu Leu 200 205 210 acc acg gag tcg ctc aag caa tta gtc acc cac atc cct gcg cgt tcc 787 Thr Thr Glu Ser Leu Lys Gln Leu Val Thr His Ile Pro Ala Arg Ser 215 220 225 gtc gac ttc atc gcc aga gtc tat gaa cta acc aat tgg tac cgc gac 835 Val Asp Phe Ile Ala Arg Val Tyr Glu Leu Thr Asn Trp Tyr Arg Asp 230 235 240 245 ctc aaa gac ctc aat gaa gta gaa gcc ttc gta ggt act cat ggg ctg 883 Leu Lys Asp Leu Asn Glu Val Glu Ala Phe Val Gly Thr His Gly Leu 250 255 260 ccg gaa ttg tct ttc aaa ttt ctt ctg gag tgt ctg agc ggc gaa gct 931 Pro Glu Leu Ser Phe Lys Phe Leu Leu Glu Cys Leu Ser Gly Glu Ala 265 270 275 gaa caa att gcc gaa aag acg aaa gca gca cca gca agc ctg gaa aac 979 Glu Gln Ile Ala Glu Lys Thr Lys Ala Ala Pro Ala Ser Leu Glu Asn 280 285 290 ctg gaa cct ccg cat ctc tat ctg gat cca cag agt ttt gaa ctc agt 1027 Leu Glu Pro Pro His Leu Tyr Leu Asp Pro Gln Ser Phe Glu Leu Ser 295 300 305 ctt gtt ttc cca gcg atc tct aaa act gca gca ctt cag att cca gca 1075 Leu Val Phe Pro Ala Ile Ser Lys Thr Ala Ala Leu Gln Ile Pro Ala 310 315 320 325 cca gaa tgg aca gtg att tat gac gga aac tcc att aaa gtt cgt ccc 1123 Pro Glu Trp Thr Val Ile Tyr Asp Gly Asn Ser Ile Lys Val Arg Pro 330 335 340 gaa cag gac tgg tcc tac gga ggt ttc gcc gaa tac cgt ttg cct tta 1171 Glu Gln Asp Trp Ser Tyr Gly Gly Phe Ala Glu Tyr Arg Leu Pro Leu 345 350 355 gac aaa ccg ctc tcc agc ttg aga gtc atc act cca aca gag aaa tcc 1219 Asp Lys Pro Leu Ser Ser Leu Arg Val Ile Thr Pro Thr Glu Lys Ser 360 365 370 cta att ctg att gaa gga ttt ggc cac aag aat ccc att atg ttc ttt 1267 Leu Ile Leu Ile Glu Gly Phe Gly His Lys Asn Pro Ile Met Phe Phe 375 380 385 aag aac aac ggt cag cca tat gca aac caa gaa atg ctc agt ggc aac 1315 Lys Asn Asn Gly Gln Pro Tyr Ala Asn Gln Glu Met Leu Ser Gly Asn 390 395 400 405 gct gtc aca gct ata gtc cca gct gca gca atc att cgt gca cgt atg 1363 Ala Val Thr Ala Ile Val Pro Ala Ala Ala Ile Ile Arg Ala Arg Met 410 415 420 cga gct tcc aag act ttc aac tat caa gac ttg ggt ccc ttg tcc gga 1411 Arg Ala Ser Lys Thr Phe Asn Tyr Gln Asp Leu Gly Pro Leu Ser Gly 425 430 435 tgg aac aag tgg gtc att cgt tcg atc cca ctc aaa cga gct gaa tcg 1459 Trp Asn Lys Trp Val Ile Arg Ser Ile Pro Leu Lys Arg Ala Glu Ser 440 445 450 atc aca gtc tcc cac ggt ggc ttc aga aaa gaa ctc cca gtt cga cgc 1507 Ile Thr Val Ser His Gly Gly Phe Arg Lys Glu Leu Pro Val Arg Arg 455 460 465 aaa gtt gat gtt caa tgg att act gag gat ctc acg atc gag aat ctt 1555 Lys Val Asp Val Gln Trp Ile Thr Glu Asp Leu Thr Ile Glu Asn Leu 470 475 480 485 caa ggt ctc gat cat gag ccc gtt ttc cac acg agt ccc cgc atc gaa 1603 Gln Gly Leu Asp His Glu Pro Val Phe His Thr Ser Pro Arg Ile Glu 490 495 500 ttc ccc acc tct gga tca aac tgg gta att cag tat tca cag att ctt 1651 Phe Pro Thr Ser Gly Ser Asn Trp Val Ile Gln Tyr Ser Gln Ile Leu 505 510 515 cca gat ggc agc ctc atc gaa atg gaa gat tac cca gtc gaa cct gaa 1699 Pro Asp Gly Ser Leu Ile Glu Met Glu Asp Tyr Pro Val Glu Pro Glu 520 525 530 aac ttc gga tac gaa cta gac ctc ttc gaa gaa tcc gac gac cct tgg 1747 Asn Phe Gly Tyr Glu Leu Asp Leu Phe Glu Glu Ser Asp Asp Pro Trp 535 540 545 gtc ggg caa ttt tta gta act ctg ctc aag gat gaa aaa gtc tat gaa 1795 Val Gly Gln Phe Leu Val Thr Leu Leu Lys Asp Glu Lys Val Tyr Glu 550 555 560 565 acc cgc aaa ttc aat ctc gcg gaa ggc ctc gat ctt tcc cta aca ttc 1843 Thr Arg Lys Phe Asn Leu Ala Glu Gly Leu Asp Leu Ser Leu Thr Phe 570 575 580 agc gga ggc gga cct gaa aat cga ttt agg tac ccc agc atc aat cag 1891 Ser Gly Gly Gly Pro Glu Asn Arg Phe Arg Tyr Pro Ser Ile Asn Gln 585 590 595 gga caa act ggc tta aca aag act ttc gcc cgt ttt agt tcc aat tct 1939 Gly Gln Thr Gly Leu Thr Lys Thr Phe Ala Arg Phe Ser Ser Asn Ser 600 605 610 gaa aag cac atc agg ttc cca gat gag atc atc ggg ctt gat gca ttc 1987 Glu Lys His Ile Arg Phe Pro Asp Glu Ile Ile Gly Leu Asp Ala Phe 615 620 625 acc tct caa aaa gcg ttt aac atc gca agc ggt gat ttc cct gag gac 2035 Thr Ser Gln Lys Ala Phe Asn Ile Ala Ser Gly Asp Phe Pro Glu Asp 630 635 640 645 tac aac ctc gac gtt ttc atc acg cct ccg caa ctt cac tac caa gta 2083 Tyr Asn Leu Asp Val Phe Ile Thr Pro Pro Gln Leu His Tyr Gln Val 650 655 660 cct gtc aca cac agc caa aca aag tgg gaa agc aca aag acg aca cta 2131 Pro Val Thr His Ser Gln Thr Lys Trp Glu Ser Thr Lys Thr Thr Leu 665 670 675 gat ttc aat gac ttt gcc gat gga aac ctc cag atc aga ttc cct aat 2179 Asp Phe Asn Asp Phe Ala Asp Gly Asn Leu Gln Ile Arg Phe Pro Asn 680 685 690 gaa gtc tat gat cca aac ttg aaa atc att aaa atg gtg gca tac aag 2227 Glu Val Tyr Asp Pro Asn Leu Lys Ile Ile Lys Met Val Ala Tyr Lys 695 700 705 aaa cct gag tcc agt gag cct aaa tac tta agc aaa att ggt tca agc 2275 Lys Pro Glu Ser Ser Glu Pro Lys Tyr Leu Ser Lys Ile Gly Ser Ser 710 715 720 725 aaa gtg tgg tct atc cct atg gat cgc atc aag gaa ctc atg gat gat 2323 Lys Val Trp Ser Ile Pro Met Asp Arg Ile Lys Glu Leu Met Asp Asp 730 735 740 gat gcc caa ttc ctt ttg atc gcg gag tgg ttc gct gaa agt aaa gac 2371 Asp Ala Gln Phe Leu Leu Ile Ala Glu Trp Phe Ala Glu Ser Lys Asp 745 750 755 cag cac cga gag aag atc att agc gaa gct aag cga act gga aaa atc 2419 Gln His Arg Glu Lys Ile Ile Ser Glu Ala Lys Arg Thr Gly Lys Ile 760 765 770 tcc aat gca gcg ctt aag agt gct cgt cct caa cct caa gca agt tcc 2467 Ser Asn Ala Ala Leu Lys Ser Ala Arg Pro Gln Pro Gln Ala Ser Ser 775 780 785 cac att gca aca att gag aaa aag ccc cta cta gct gcg gct gaa att 2515 His Ile Ala Thr Ile Glu Lys Lys Pro Leu Leu Ala Ala Ala Glu Ile 790 795 800 805 aag ctt tct acc gtg gag ttg gaa ctt ggt cgg cac act tct aag aga 2563 Lys Leu Ser Thr Val Glu Leu Glu Leu Gly Arg His Thr Ser Lys Arg 810 815 820 ctg gaa ggc tgg gca tgg tct gcg ctc aac ccg ctt gat cca cca atc 2611 Leu Glu Gly Trp Ala Trp Ser Ala Leu Asn Pro Leu Asp Pro Pro Ile 825 830 835 aaa gtc gat ttc caa gga acc tca ggc tca ctt cca gac acc cac ttc 2659 Lys Val Asp Phe Gln Gly Thr Ser Gly Ser Leu Pro Asp Thr His Phe 840 845 850 gtc gtt ggc cct tta atc gtg gaa gtg aga gaa aaa gag ttt ctc tcc 2707 Val Val Gly Pro Leu Ile Val Glu Val Arg Glu Lys Glu Phe Leu Ser 855 860 865 caa tgg cag cca aaa gtt ccc tca gtt aaa gcc gtg gtt gca aat gat 2755 Gln Trp Gln Pro Lys Val Pro Ser Val Lys Ala Val Val Ala Asn Asp 870 875 880 885 ccc tca ttt gaa ttg gac cct caa ttt gat cct ttc ctc aca cac cga 2803 Pro Ser Phe Glu Leu Asp Pro Gln Phe Asp Pro Phe Leu Thr His Arg 890 895 900 tgg atg ttc gct cca cga agt ggg aag gtc tta ctc cca caa gaa atc 2851 Trp Met Phe Ala Pro Arg Ser Gly Lys Val Leu Leu Pro Gln Glu Ile 905 910 915 cgc aca gtg tgg gac gcc cga ttc aat atg cgc cat gtc tta gcg cag 2899 Arg Thr Val Trp Asp Ala Arg Phe Asn Met Arg His Val Leu Ala Gln 920 925 930 cgt gaa aac ctt cat gtg aaa tcg att caa gat ttt gac gat gcc acc 2947 Arg Glu Asn Leu His Val Lys Ser Ile Gln Asp Phe Asp Asp Ala Thr 935 940 945 agt acc tat ctc acc agt gat cct cgg gtg gca tta gat gaa ttg gat 2995 Ser Thr Tyr Leu Thr Ser Asp Pro Arg Val Ala Leu Asp Glu Leu Asp 950 955 960 965 aag agc tca att ccg tct aat tcc cac ttt gaa tca ttc atc cga tcc 3043 Lys Ser Ser Ile Pro Ser Asn Ser His Phe Glu Ser Phe Ile Arg Ser 970 975 980 gga tta gct gag ctt tct ttc gaa gtt gac gac aca gcc gga gat atc 3091 Gly Leu Ala Glu Leu Ser Phe Glu Val Asp Asp Thr Ala Gly Asp Ile 985 990 995 cat cgc gtt ccc tgg atc ggc ctg atc cag gaa atg aac gac ctc aga 3139 His Arg Val Pro Trp Ile Gly Leu Ile Gln Glu Met Asn Asp Leu Arg 1000 1005 1010 att ctg cag ata caa ggc tat gaa aca gaa gaa cga gcc atc gaa cgc 3187 Ile Leu Gln Ile Gln Gly Tyr Glu Thr Glu Glu Arg Ala Ile Glu Arg 1015 1020 1025 cga aat tcg cag agc tac atc cgt gag ata gga ggc agt gaa ttg tgg 3235 Arg Asn Ser Gln Ser Tyr Ile Arg Glu Ile Gly Gly Ser Glu Leu Trp 1030 1035 1040 1045 aat atc cta aaa gga aat tca gag gga ttg tct ctt gct caa aaa tgc 3283 Asn Ile Leu Lys Gly Asn Ser Glu Gly Leu Ser Leu Ala Gln Lys Cys 1050 1055 1060 gca cca caa gcc act gag att aat gtg att cgt aat tca ggc ttg gaa 3331 Ala Pro Gln Ala Thr Glu Ile Asn Val Ile Arg Asn Ser Gly Leu Glu 1065 1070 1075 gct atg cgc aat ggg ctg ggc gcc gat cag ttc agc gcc gag ttt att 3379 Ala Met Arg Asn Gly Leu Gly Ala Asp Gln Phe Ser Ala Glu Phe Ile 1080 1085 1090 tca gca gac tca cgc cta cga gct cag ctt gaa tgg ttg gaa aac cgc 3427 Ser Ala Asp Ser Arg Leu Arg Ala Gln Leu Glu Trp Leu Glu Asn Arg 1095 1100 1105 cga gag ctc aat gat ctc ggc cag ctc cca acg ctc ttc gat ttc gcc 3475 Arg Glu Leu Asn Asp Leu Gly Gln Leu Pro Thr Leu Phe Asp Phe Ala 1110 1115 1120 1125 gag aaa tac gag tac ctc atc gat cac tta ggt gat gat cgc atc aag 3523 Glu Lys Tyr Glu Tyr Leu Ile Asp His Leu Gly Asp Asp Arg Ile Lys 1130 1135 1140 gtc act gca cgt gag ctg tct act ctt gcg tcg gaa cac cgt cgc ggc 3571 Val Thr Ala Arg Glu Leu Ser Thr Leu Ala Ser Glu His Arg Arg Gly 1145 1150 1155 aac gct gaa aac tgg ctt tat gca cca tat gtg tca ttc att tac agc 3619 Asn Ala Glu Asn Trp Leu Tyr Ala Pro Tyr Val Ser Phe Ile Tyr Ser 1160 1165 1170 ttg ctt aac cga atg atc gct cat gaa gta ata cgt ccg atc gct cag 3667 Leu Leu Asn Arg Met Ile Ala His Glu Val Ile Arg Pro Ile Ala Gln 1175 1180 1185 atc aat tac tca cgg cac gat tgg gca aac gct gct cgg ctg att cct 3715 Ile Asn Tyr Ser Arg His Asp Trp Ala Asn Ala Ala Arg Leu Ile Pro 1190 1195 1200 1205 cgt ctc aca gga ttt gac ctg gtg agt gcc gaa gcg aaa gtg ctc agc 3763 Arg Leu Thr Gly Phe Asp Leu Val Ser Ala Glu Ala Lys Val Leu Ser 1210 1215 1220 gca ata aac aac aac aat ata atc cca act gca att taaggatcac 3809 Ala Ile Asn Asn Asn Asn Ile Ile Pro Thr Ala Ile 1225 1230 tatgtccaac gcacctaaaa 3829 <210> 290 <211> 1233 <212> PRT <213> Corynebacterium glutamicum <400> 290 Val Thr Ile Ser Arg Arg Leu Lys Gln Glu Arg Ser Phe Ala Asp Asp 1 5 10 15 Leu Gln Asp Leu Lys Thr Leu Asn Asp Gln Leu Arg Phe Thr Asn Ala 20 25 30 Lys Leu Gln Ala Arg Ile Ser Gly Ile Gly Asn Asp Gly Lys Lys Ile 35 40 45 Thr Arg Pro Thr Pro Leu Leu Ala Leu Asp Phe Gln Leu Thr Val Glu 50 55 60 Glu Tyr Glu Thr Ile Ile Ala Ile Leu Val Glu Ala Val Gly Gly Asn 65 70 75 80 Gln Ser Lys Pro Ala Ile Leu Lys Asp Leu Phe Ile Glu Tyr Pro Leu 85 90 95 Val Phe Leu Ala Ala Leu Ser Gly Thr Ala Met Leu Asp Ala Gln Glu 100 105 110 Gly Phe Trp Pro Ala Phe Trp Lys Arg Thr Gln Val Ser Val Pro Glu 115 120 125 His Val Tyr Asp Ala Ile Arg Lys Glu Leu Val Asn Ser Ile Arg Lys 130 135 140 Asn Gly Leu Glu Thr Phe Ser Leu Ala Asp Leu Asn Arg Arg Glu Tyr 145 150 155 160 Val Gly Leu Ile Gln Leu His Ser Gly Leu Ser Ala Lys Asp Met Leu 165 170 175 Ala Leu Val Lys Phe Ile Asp His Thr Arg Ala Glu Asn Gln Gly Trp 180 185 190 Asp Ser Gly Glu Asp Phe Ala Ser Tyr Ala Lys Ser Val Phe Ser Ser 195 200 205 Gly Asp Asn Leu Leu Thr Thr Glu Ser Leu Lys Gln Leu Val Thr His 210 215 220 Ile Pro Ala Arg Ser Val Asp Phe Ile Ala Arg Val Tyr Glu Leu Thr 225 230 235 240 Asn Trp Tyr Arg Asp Leu Lys Asp Leu Asn Glu Val Glu Ala Phe Val 245 250 255 Gly Thr His Gly Leu Pro Glu Leu Ser Phe Lys Phe Leu Leu Glu Cys 260 265 270 Leu Ser Gly Glu Ala Glu Gln Ile Ala Glu Lys Thr Lys Ala Ala Pro 275 280 285 Ala Ser Leu Glu Asn Leu Glu Pro Pro His Leu Tyr Leu Asp Pro Gln 290 295 300 Ser Phe Glu Leu Ser Leu Val Phe Pro Ala Ile Ser Lys Thr Ala Ala 305 310 315 320 Leu Gln Ile Pro Ala Pro Glu Trp Thr Val Ile Tyr Asp Gly Asn Ser 325 330 335 Ile Lys Val Arg Pro Glu Gln Asp Trp Ser Tyr Gly Gly Phe Ala Glu 340 345 350 Tyr Arg Leu Pro Leu Asp Lys Pro Leu Ser Ser Leu Arg Val Ile Thr 355 360 365 Pro Thr Glu Lys Ser Leu Ile Leu Ile Glu Gly Phe Gly His Lys Asn 370 375 380 Pro Ile Met Phe Phe Lys Asn Asn Gly Gln Pro Tyr Ala Asn Gln Glu 385 390 395 400 Met Leu Ser Gly Asn Ala Val Thr Ala Ile Val Pro Ala Ala Ala Ile 405 410 415 Ile Arg Ala Arg Met Arg Ala Ser Lys Thr Phe Asn Tyr Gln Asp Leu 420 425 430 Gly Pro Leu Ser Gly Trp Asn Lys Trp Val Ile Arg Ser Ile Pro Leu 435 440 445 Lys Arg Ala Glu Ser Ile Thr Val Ser His Gly Gly Phe Arg Lys Glu 450 455 460 Leu Pro Val Arg Arg Lys Val Asp Val Gln Trp Ile Thr Glu Asp Leu 465 470 475 480 Thr Ile Glu Asn Leu Gln Gly Leu Asp His Glu Pro Val Phe His Thr 485 490 495 Ser Pro Arg Ile Glu Phe Pro Thr Ser Gly Ser Asn Trp Val Ile Gln 500 505 510 Tyr Ser Gln Ile Leu Pro Asp Gly Ser Leu Ile Glu Met Glu Asp Tyr 515 520 525 Pro Val Glu Pro Glu Asn Phe Gly Tyr Glu Leu Asp Leu Phe Glu Glu 530 535 540 Ser Asp Asp Pro Trp Val Gly Gln Phe Leu Val Thr Leu Leu Lys Asp 545 550 555 560 Glu Lys Val Tyr Glu Thr Arg Lys Phe Asn Leu Ala Glu Gly Leu Asp 565 570 575 Leu Ser Leu Thr Phe Ser Gly Gly Gly Pro Glu Asn Arg Phe Arg Tyr 580 585 590 Pro Ser Ile Asn Gln Gly Gln Thr Gly Leu Thr Lys Thr Phe Ala Arg 595 600 605 Phe Ser Ser Asn Ser Glu Lys His Ile Arg Phe Pro Asp Glu Ile Ile 610 615 620 Gly Leu Asp Ala Phe Thr Ser Gln Lys Ala Phe Asn Ile Ala Ser Gly 625 630 635 640 Asp Phe Pro Glu Asp Tyr Asn Leu Asp Val Phe Ile Thr Pro Pro Gln 645 650 655 Leu His Tyr Gln Val Pro Val Thr His Ser Gln Thr Lys Trp Glu Ser 660 665 670 Thr Lys Thr Thr Leu Asp Phe Asn Asp Phe Ala Asp Gly Asn Leu Gln 675 680 685 Ile Arg Phe Pro Asn Glu Val Tyr Asp Pro Asn Leu Lys Ile Ile Lys 690 695 700 Met Val Ala Tyr Lys Lys Pro Glu Ser Ser Glu Pro Lys Tyr Leu Ser 705 710 715 720 Lys Ile Gly Ser Ser Lys Val Trp Ser Ile Pro Met Asp Arg Ile Lys 725 730 735 Glu Leu Met Asp Asp Asp Ala Gln Phe Leu Leu Ile Ala Glu Trp Phe 740 745 750 Ala Glu Ser Lys Asp Gln His Arg Glu Lys Ile Ile Ser Glu Ala Lys 755 760 765 Arg Thr Gly Lys Ile Ser Asn Ala Ala Leu Lys Ser Ala Arg Pro Gln 770 775 780 Pro Gln Ala Ser Ser His Ile Ala Thr Ile Glu Lys Lys Pro Leu Leu 785 790 795 800 Ala Ala Ala Glu Ile Lys Leu Ser Thr Val Glu Leu Glu Leu Gly Arg 805 810 815 His Thr Ser Lys Arg Leu Glu Gly Trp Ala Trp Ser Ala Leu Asn Pro 820 825 830 Leu Asp Pro Pro Ile Lys Val Asp Phe Gln Gly Thr Ser Gly Ser Leu 835 840 845 Pro Asp Thr His Phe Val Val Gly Pro Leu Ile Val Glu Val Arg Glu 850 855 860 Lys Glu Phe Leu Ser Gln Trp Gln Pro Lys Val Pro Ser Val Lys Ala 865 870 875 880 Val Val Ala Asn Asp Pro Ser Phe Glu Leu Asp Pro Gln Phe Asp Pro 885 890 895 Phe Leu Thr His Arg Trp Met Phe Ala Pro Arg Ser Gly Lys Val Leu 900 905 910 Leu Pro Gln Glu Ile Arg Thr Val Trp Asp Ala Arg Phe Asn Met Arg 915 920 925 His Val Leu Ala Gln Arg Glu Asn Leu His Val Lys Ser Ile Gln Asp 930 935 940 Phe Asp Asp Ala Thr Ser Thr Tyr Leu Thr Ser Asp Pro Arg Val Ala 945 950 955 960 Leu Asp Glu Leu Asp Lys Ser Ser Ile Pro Ser Asn Ser His Phe Glu 965 970 975 Ser Phe Ile Arg Ser Gly Leu Ala Glu Leu Ser Phe Glu Val Asp Asp 980 985 990 Thr Ala Gly Asp Ile His Arg Val Pro Trp Ile Gly Leu Ile Gln Glu 995 1000 1005 Met Asn Asp Leu Arg Ile Leu Gln Ile Gln Gly Tyr Glu Thr Glu Glu 1010 1015 1020 Arg Ala Ile Glu Arg Arg Asn Ser Gln Ser Tyr Ile Arg Glu Ile Gly 1025 1030 1035 1040 Gly Ser Glu Leu Trp Asn Ile Leu Lys Gly Asn Ser Glu Gly Leu Ser 1045 1050 1055 Leu Ala Gln Lys Cys Ala Pro Gln Ala Thr Glu Ile Asn Val Ile Arg 1060 1065 1070 Asn Ser Gly Leu Glu Ala Met Arg Asn Gly Leu Gly Ala Asp Gln Phe 1075 1080 1085 Ser Ala Glu Phe Ile Ser Ala Asp Ser Arg Leu Arg Ala Gln Leu Glu 1090 1095 1100 Trp Leu Glu Asn Arg Arg Glu Leu Asn Asp Leu Gly Gln Leu Pro Thr 1105 1110 1115 1120 Leu Phe Asp Phe Ala Glu Lys Tyr Glu Tyr Leu Ile Asp His Leu Gly 1125 1130 1135 Asp Asp Arg Ile Lys Val Thr Ala Arg Glu Leu Ser Thr Leu Ala Ser 1140 1145 1150 Glu His Arg Arg Gly Asn Ala Glu Asn Trp Leu Tyr Ala Pro Tyr Val 1155 1160 1165 Ser Phe Ile Tyr Ser Leu Leu Asn Arg Met Ile Ala His Glu Val Ile 1170 1175 1180 Arg Pro Ile Ala Gln Ile Asn Tyr Ser Arg His Asp Trp Ala Asn Ala 1185 1190 1195 1200 Ala Arg Leu Ile Pro Arg Leu Thr Gly Phe Asp Leu Val Ser Ala Glu 1205 1210 1215 Ala Lys Val Leu Ser Ala Ile Asn Asn Asn Asn Ile Ile Pro Thr Ala 1220 1225 1230 Ile <210> 291 <211> 793 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(763) <223> RXA02367 <400> 291 ggatccagga aaagtattca tcgaagtttc cctgaaaggg atctcagcca tcaaggcact 60 tgaatccgga cgctaagttg ttgatacatc aacttatttc ttg gct ata ctt gag 115 Leu Ala Ile Leu Glu 1 5 gtc acg ttt cct cag ctc agg aga agt tcg gag aag tcc atg tca aac 163 Val Thr Phe Pro Gln Leu Arg Arg Ser Ser Glu Lys Ser Met Ser Asn 10 15 20 gca gaa att aat ccc gtt gaa tat gaa atc aac aac cac gcc cct ggt 211 Ala Glu Ile Asn Pro Val Glu Tyr Glu Ile Asn Asn His Ala Pro Gly 25 30 35 acc gcg cta aac cca cag tgc gaa gac ggc gcc aac gta gaa atc atc 259 Thr Ala Leu Asn Pro Gln Cys Glu Asp Gly Ala Asn Val Glu Ile Ile 40 45 50 acc tcc cgt gaa gtc ccc ctc ggc gga cca cgc gcc atg acc gtg cac 307 Thr Ser Arg Glu Val Pro Leu Gly Gly Pro Arg Ala Met Thr Val His 55 60 65 cgc aca ctc ccc caa cgc cag cgc tcc ctc atc ggt gcc tgg tgt ttt 355 Arg Thr Leu Pro Gln Arg Gln Arg Ser Leu Ile Gly Ala Trp Cys Phe 70 75 80 85 gtg gat cat tac ggc ccc gat gat gtc tca cta acc ggt ggc atg gat 403 Val Asp His Tyr Gly Pro Asp Asp Val Ser Leu Thr Gly Gly Met Asp 90 95 100 atg gcc tcc cac ccg cac acc gga ttg caa aca gtc acg tgg ctt ttt 451 Met Ala Ser His Pro His Thr Gly Leu Gln Thr Val Thr Trp Leu Phe 105 110 115 gaa ggc gaa gtc acc cac cat gat tcc ggc gga aat cac gca gtc gtg 499 Glu Gly Glu Val Thr His His Asp Ser Gly Gly Asn His Ala Val Val 120 125 130 ctt cct ggc gaa gtc aac ctc atg acc gcc ggc gca ggc atc tgt cac 547 Leu Pro Gly Glu Val Asn Leu Met Thr Ala Gly Ala Gly Ile Cys His 135 140 145 acc gaa gtt tcc gcc acc tcc acc acg att ctg cat ggt ctg cag ttg 595 Thr Glu Val Ser Ala Thr Ser Thr Thr Ile Leu His Gly Leu Gln Leu 150 155 160 165 tgg aca gtt ctt ccc gac aaa gac cgc gaa gga cca cgc cgc ttt gat 643 Trp Thr Val Leu Pro Asp Lys Asp Arg Glu Gly Pro Arg Arg Phe Asp 170 175 180 cac tac gct cca gaa gaa atc aca ctc gaa ggc gga agt gca cgc gtt 691 His Tyr Ala Pro Glu Glu Ile Thr Leu Glu Gly Gly Ser Ala Arg Val 185 190 195 ttc cta ggt tcg cta ttt ggt caa acc tcc cct gtt cat acg ttt act 739 Phe Leu Gly Ser Leu Phe Gly Gln Thr Ser Pro Val His Thr Phe Thr 200 205 210 ggc tct tcc tgt ttt aga gtg cat tgatcttatg gaccaactgc cctgaatgga 793 Gly Ser Ser Cys Phe Arg Val His 215 220 <210> 292 <211> 221 <212> PRT <213> Corynebacterium glutamicum <400> 292 Leu Ala Ile Leu Glu Val Thr Phe Pro Gln Leu Arg Arg Ser Ser Glu 1 5 10 15 Lys Ser Met Ser Asn Ala Glu Ile Asn Pro Val Glu Tyr Glu Ile Asn 20 25 30 Asn His Ala Pro Gly Thr Ala Leu Asn Pro Gln Cys Glu Asp Gly Ala 35 40 45 Asn Val Glu Ile Ile Thr Ser Arg Glu Val Pro Leu Gly Gly Pro Arg 50 55 60 Ala Met Thr Val His Arg Thr Leu Pro Gln Arg Gln Arg Ser Leu Ile 65 70 75 80 Gly Ala Trp Cys Phe Val Asp His Tyr Gly Pro Asp Asp Val Ser Leu 85 90 95 Thr Gly Gly Met Asp Met Ala Ser His Pro His Thr Gly Leu Gln Thr 100 105 110 Val Thr Trp Leu Phe Glu Gly Glu Val Thr His His Asp Ser Gly Gly 115 120 125 Asn His Ala Val Val Leu Pro Gly Glu Val Asn Leu Met Thr Ala Gly 130 135 140 Ala Gly Ile Cys His Thr Glu Val Ser Ala Thr Ser Thr Thr Ile Leu 145 150 155 160 His Gly Leu Gln Leu Trp Thr Val Leu Pro Asp Lys Asp Arg Glu Gly 165 170 175 Pro Arg Arg Phe Asp His Tyr Ala Pro Glu Glu Ile Thr Leu Glu Gly 180 185 190 Gly Ser Ala Arg Val Phe Leu Gly Ser Leu Phe Gly Gln Thr Ser Pro 195 200 205 Val His Thr Phe Thr Gly Ser Ser Cys Phe Arg Val His 210 215 220 <210> 293 <211> 1123 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1093) <223> RXA02387 <400> 293 cagagaagga atccctgtgc tgtatccata ccgcgatggg gaggtcagcc ttcatattga 60 tggcacccag catgcagcgg acgggagatt ttaacgacac ttg tgg cac gat ggt 115 Leu Trp His Asp Gly 1 5 cac gtg gct tca gca cct att tca gtt caa cca gcg gtc cat ctt gtt 163 His Val Ala Ser Ala Pro Ile Ser Val Gln Pro Ala Val His Leu Val 10 15 20 ctc ggc gag gat gag ttc ctt gcc gaa cgc gcg cgt atc aac atc gtg 211 Leu Gly Glu Asp Glu Phe Leu Ala Glu Arg Ala Arg Ile Asn Ile Val 25 30 35 cat gac atc cgt tca tcg atg gct agc ccc gat tcg ctt cag gtc acc 259 His Asp Ile Arg Ser Ser Met Ala Ser Pro Asp Ser Leu Gln Val Thr 40 45 50 acc ttg aag gcc agc gaa att act cag ggt gaa ttg ttg gat gcg tta 307 Thr Leu Lys Ala Ser Glu Ile Thr Gln Gly Glu Leu Leu Asp Ala Leu 55 60 65 agc cca tcc ttg ttt gct gaa gac cgt gtg gtg gtg ctt acc aac atg 355 Ser Pro Ser Leu Phe Ala Glu Asp Arg Val Val Val Leu Thr Asn Met 70 75 80 85 gat caa gca ggc caa gat gct gta gat cta gcc tta tcc gca gca gtt 403 Asp Gln Ala Gly Gln Asp Ala Val Asp Leu Ala Leu Ser Ala Ala Val 90 95 100 gat ccc agc cct ggt acc tac ttg atc gtc atg cac tct ggc ggt gga 451 Asp Pro Ser Pro Gly Thr Tyr Leu Ile Val Met His Ser Gly Gly Gly 105 110 115 cgc tct aag tcg atg gtg aag aag ctg gaa aaa gtc gcg gtg gtg cac 499 Arg Ser Lys Ser Met Val Lys Lys Leu Glu Lys Val Ala Val Val His 120 125 130 gat gcc gca aag ctg aaa gac cgg gat cgt cca ggt tgg gta aaa caa 547 Asp Ala Ala Lys Leu Lys Asp Arg Asp Arg Pro Gly Trp Val Lys Gln 135 140 145 gag ttc aaa aac cac aaa gtc cag gtc acc cca gat gtc att cat gct 595 Glu Phe Lys Asn His Lys Val Gln Val Thr Pro Asp Val Ile His Ala 150 155 160 165 ctt tta gag ggc gtg ggt tca gat ctt aga gag ctg gcg tcc gcc gta 643 Leu Leu Glu Gly Val Gly Ser Asp Leu Arg Glu Leu Ala Ser Ala Val 170 175 180 tcc caa ttg gtt gag gac acc caa ggc aac gtg acg gtg gaa aaa gtc 691 Ser Gln Leu Val Glu Asp Thr Gln Gly Asn Val Thr Val Glu Lys Val 185 190 195 cgt gcc tat tac gtg ggt gtt gct gag gta tcg ggt ttc gac atc gcc 739 Arg Ala Tyr Tyr Val Gly Val Ala Glu Val Ser Gly Phe Asp Ile Ala 200 205 210 gat tct gca tgc gcc ggt caa atg tca aag gcc gtg gcc agc acc aga 787 Asp Ser Ala Cys Ala Gly Gln Met Ser Lys Ala Val Ala Ser Thr Arg 215 220 225 cgt gcc ctt caa ttg ggt acc agc ccg gtt gca ttg gca gct gcg ttg 835 Arg Ala Leu Gln Leu Gly Thr Ser Pro Val Ala Leu Ala Ala Ala Leu 230 235 240 245 agt atg aaa gtt ggc cag atc gcc agg ctg tat tcc acc agg gga cgc 883 Ser Met Lys Val Gly Gln Ile Ala Arg Leu Tyr Ser Thr Arg Gly Arg 250 255 260 atc aac ggt ttt gag ctg gcc aaa gaa ttg ggc atg ccg ccg ttc gtg 931 Ile Asn Gly Phe Glu Leu Ala Lys Glu Leu Gly Met Pro Pro Phe Val 265 270 275 gtg gag aag act gcg aaa gtg gcc cga aac tgg tcg gga gat gcg gtc 979 Val Glu Lys Thr Ala Lys Val Ala Arg Asn Trp Ser Gly Asp Ala Val 280 285 290 agc gag gcc gtg att ttg atg gcc gat ctg gat gcc gct gta aaa gga 1027 Ser Glu Ala Val Ile Leu Met Ala Asp Leu Asp Ala Ala Val Lys Gly 295 300 305 caa agt ggc gat cct gaa ttt gcc atc gaa tct gcc gtg aga aga gtt 1075 Gln Ser Gly Asp Pro Glu Phe Ala Ile Glu Ser Ala Val Arg Arg Val 310 315 320 325 gca gag ctg gcg agg cgg taacgctgaa cggcggcggg taagatattt 1123 Ala Glu Leu Ala Arg Arg 330 <210> 294 <211> 331 <212> PRT <213> Corynebacterium glutamicum <400> 294 Leu Trp His Asp Gly His Val Ala Ser Ala Pro Ile Ser Val Gln Pro 1 5 10 15 Ala Val His Leu Val Leu Gly Glu Asp Glu Phe Leu Ala Glu Arg Ala 20 25 30 Arg Ile Asn Ile Val His Asp Ile Arg Ser Ser Met Ala Ser Pro Asp 35 40 45 Ser Leu Gln Val Thr Thr Leu Lys Ala Ser Glu Ile Thr Gln Gly Glu 50 55 60 Leu Leu Asp Ala Leu Ser Pro Ser Leu Phe Ala Glu Asp Arg Val Val 65 70 75 80 Val Leu Thr Asn Met Asp Gln Ala Gly Gln Asp Ala Val Asp Leu Ala 85 90 95 Leu Ser Ala Ala Val Asp Pro Ser Pro Gly Thr Tyr Leu Ile Val Met 100 105 110 His Ser Gly Gly Gly Arg Ser Lys Ser Met Val Lys Lys Leu Glu Lys 115 120 125 Val Ala Val Val His Asp Ala Ala Lys Leu Lys Asp Arg Asp Arg Pro 130 135 140 Gly Trp Val Lys Gln Glu Phe Lys Asn His Lys Val Gln Val Thr Pro 145 150 155 160 Asp Val Ile His Ala Leu Leu Glu Gly Val Gly Ser Asp Leu Arg Glu 165 170 175 Leu Ala Ser Ala Val Ser Gln Leu Val Glu Asp Thr Gln Gly Asn Val 180 185 190 Thr Val Glu Lys Val Arg Ala Tyr Tyr Val Gly Val Ala Glu Val Ser 195 200 205 Gly Phe Asp Ile Ala Asp Ser Ala Cys Ala Gly Gln Met Ser Lys Ala 210 215 220 Val Ala Ser Thr Arg Arg Ala Leu Gln Leu Gly Thr Ser Pro Val Ala 225 230 235 240 Leu Ala Ala Ala Leu Ser Met Lys Val Gly Gln Ile Ala Arg Leu Tyr 245 250 255 Ser Thr Arg Gly Arg Ile Asn Gly Phe Glu Leu Ala Lys Glu Leu Gly 260 265 270 Met Pro Pro Phe Val Val Glu Lys Thr Ala Lys Val Ala Arg Asn Trp 275 280 285 Ser Gly Asp Ala Val Ser Glu Ala Val Ile Leu Met Ala Asp Leu Asp 290 295 300 Ala Ala Val Lys Gly Gln Ser Gly Asp Pro Glu Phe Ala Ile Glu Ser 305 310 315 320 Ala Val Arg Arg Val Ala Glu Leu Ala Arg Arg 325 330 <210> 295 <211> 799 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(769) <223> RXA02390 <400> 295 gctggtggtg ctgacccata cgctggaact ccaactgctg ttgataccgc caagatgttt 60 ggccgcgagg atctcgtagc tcgcttcgag tcataggccg gtg gag tgg acc gct 115 Val Glu Trp Thr Ala 1 5 ttt ggc acc ctg att ctg ctc aat ttg gtg ggc agt tta tcc ccg ggg 163 Phe Gly Thr Leu Ile Leu Leu Asn Leu Val Gly Ser Leu Ser Pro Gly 10 15 20 cct gat acc ttt ttc ctc ctc cgc tta gcc acc cgc tcc aga gcg cac 211 Pro Asp Thr Phe Phe Leu Leu Arg Leu Ala Thr Arg Ser Arg Ala His 25 30 35 gcg atc gct ggc gtc gcc ggc atc gtc acc gga ctc acg gtg tgg gtg 259 Ala Ile Ala Gly Val Ala Gly Ile Val Thr Gly Leu Thr Val Trp Val 40 45 50 acg ctg acg gtc gtg gga gca gcg gcg ctg ctc acc act tat ccg tcg 307 Thr Leu Thr Val Val Gly Ala Ala Ala Leu Leu Thr Thr Tyr Pro Ser 55 60 65 att ctc gga atc atc cag ctc gtc ggc ggc acg tac cta agc ttc att 355 Ile Leu Gly Ile Ile Gln Leu Val Gly Gly Thr Tyr Leu Ser Phe Ile 70 75 80 85 ggg tac aag ttg ctg cgc tcg gcg tcg aga gag ctt atc gac gcc cgc 403 Gly Tyr Lys Leu Leu Arg Ser Ala Ser Arg Glu Leu Ile Asp Ala Arg 90 95 100 cag ttc cgt ttc aac gcc gat gcc cga cct atc ccg gat gcg gta gaa 451 Gln Phe Arg Phe Asn Ala Asp Ala Arg Pro Ile Pro Asp Ala Val Glu 105 110 115 gca ctg gga acc cgc act cag gta tat cga caa ggt ttg gcc acc aac 499 Ala Leu Gly Thr Arg Thr Gln Val Tyr Arg Gln Gly Leu Ala Thr Asn 120 125 130 ctg tca aac cct aaa gtt gtc atg tac ttc gcg gca att ctg gct ccg 547 Leu Ser Asn Pro Lys Val Val Met Tyr Phe Ala Ala Ile Leu Ala Pro 135 140 145 ttg atg cca gcg cac cca tca ccg gtg ctg gcg ttc tct atc atc gtg 595 Leu Met Pro Ala His Pro Ser Pro Val Leu Ala Phe Ser Ile Ile Val 150 155 160 165 gcg att tta gtg cag acc ttt gtt acc ttc tct gct gtg tgc ctc att 643 Ala Ile Leu Val Gln Thr Phe Val Thr Phe Ser Ala Val Cys Leu Ile 170 175 180 gtc tct acg gag cgt gtg cgc aaa gca atg ctg cgt gca ggt ccc tgg 691 Val Ser Thr Glu Arg Val Arg Lys Ala Met Leu Arg Ala Gly Pro Trp 185 190 195 ttt gac ctg ctt gct ggc gtt gtc ttc ctc gtt gtg ggt gtg act ctg 739 Phe Asp Leu Leu Ala Gly Val Val Phe Leu Val Val Gly Val Thr Leu 200 205 210 ctg tat gaa ggc ctg acc ggt tta ctc ggg taaaggcata aaaaatggct 789 Leu Tyr Glu Gly Leu Thr Gly Leu Leu Gly 215 220 tccaatcaaa 799 <210> 296 <211> 223 <212> PRT <213> Corynebacterium glutamicum <400> 296 Val Glu Trp Thr Ala Phe Gly Thr Leu Ile Leu Leu Asn Leu Val Gly 1 5 10 15 Ser Leu Ser Pro Gly Pro Asp Thr Phe Phe Leu Leu Arg Leu Ala Thr 20 25 30 Arg Ser Arg Ala His Ala Ile Ala Gly Val Ala Gly Ile Val Thr Gly 35 40 45 Leu Thr Val Trp Val Thr Leu Thr Val Val Gly Ala Ala Ala Leu Leu 50 55 60 Thr Thr Tyr Pro Ser Ile Leu Gly Ile Ile Gln Leu Val Gly Gly Thr 65 70 75 80 Tyr Leu Ser Phe Ile Gly Tyr Lys Leu Leu Arg Ser Ala Ser Arg Glu 85 90 95 Leu Ile Asp Ala Arg Gln Phe Arg Phe Asn Ala Asp Ala Arg Pro Ile 100 105 110 Pro Asp Ala Val Glu Ala Leu Gly Thr Arg Thr Gln Val Tyr Arg Gln 115 120 125 Gly Leu Ala Thr Asn Leu Ser Asn Pro Lys Val Val Met Tyr Phe Ala 130 135 140 Ala Ile Leu Ala Pro Leu Met Pro Ala His Pro Ser Pro Val Leu Ala 145 150 155 160 Phe Ser Ile Ile Val Ala Ile Leu Val Gln Thr Phe Val Thr Phe Ser 165 170 175 Ala Val Cys Leu Ile Val Ser Thr Glu Arg Val Arg Lys Ala Met Leu 180 185 190 Arg Ala Gly Pro Trp Phe Asp Leu Leu Ala Gly Val Val Phe Leu Val 195 200 205 Val Gly Val Thr Leu Leu Tyr Glu Gly Leu Thr Gly Leu Leu Gly 210 215 220 <210> 297 <211> 2035 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2005) <223> RXA02395 <400> 297 ttgcttataa tacaaaaaca ggaatattta actcgacttc ttaaaaaagc tctatacgta 60 aatatcttgc ccatccagca ccacctcatt gtggtgcaca atg gag agg aca cac 115 Met Glu Arg Thr His 1 5 atg tcc acc aac tct ggc aat aac ttg cct gaa tcc caa gag tca ccc 163 Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro 10 15 20 gag gaa cct cat tat cct cac gac acc cac cca ggc cta gtt cct ggc 211 Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly 25 30 35 att tcg gtc gat gct caa cgc aac aag ttc gga ctc gac aaa acc gtt 259 Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val 40 45 50 ttc ggc gtc acc gca gca tta att ctg gcg ttc atc gcc tgg ggc att 307 Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile 55 60 65 tcc agc cct gat tcg gtt tct tca gta tcg tcc acg atg ttc agt tgg 355 Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp 70 75 80 85 gct atg acg aat act ggt tgg ctc ctc aac ttt gtc atg ctg atc ggc 403 Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly 90 95 100 att ggc acc atg ctc tac atc gct ttt tcg cgc tac ggc cgc atc aag 451 Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys 105 110 115 ctg ggc acg gac gaa gac gaa cca gaa ttc tct cgc ttt tcc tgg att 499 Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile 120 125 130 gcg atg atg ttc ggc gcc ggc atc ggt gtc ggt atc ttc ttc ttc ggt 547 Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly 135 140 145 cct tcc gaa ccg ctg tgg cat tat ctc agt ccc cca cct cac acc gtg 595 Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val 150 155 160 165 gaa gga tct aca cct gag tcc ttg cac caa gca ctt gcg cag tcc cac 643 Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His 170 175 180 ttc cac tgg ggc tta tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc 691 Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly 185 190 195 gcg ttg gcg tac tcc agt tac cga cgc ggc cgc gta acc ttg atc agc 739 Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser 200 205 210 tcc acc ttc cgg tca ctt ttc ggt gag aaa acc gaa ggt atc gcg ggt 787 Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly 215 220 225 cgc ctc atc gac atg atg gcg atc atc gcc acg ctg ttt gga acg gct 835 Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala 230 235 240 245 gca acc ttg ggc ctt tca gca att cag gtt ggt cag ggc gtg cag att 883 Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile 250 255 260 att tct ggc gct tcg gaa atc acc aac aac atc ttg atc gcc atc atc 931 Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile 265 270 275 gcg atc ttg acc att ggc ttc atc atc tcc tca gta tct ggc gtg tcc 979 Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser 280 285 290 aag ggc att cgt tat ctt tcc aac ctc aat att tcc ttg acg ctt gga 1027 Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly 295 300 305 ttg gtc ctg ttt gtg ttc atc acc ggc ccc acc ttg ttc ctg ctc aac 1075 Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn 310 315 320 325 ttg atc cca tcg agt gtg ttg gaa tat ggc agt gag ttc ttg tca atg 1123 Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met 330 335 340 gct ggc aag tct ttg tcg tgg ggt gag gaa acc att gaa ttc caa gct 1171 Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala 345 350 355 ggt tgg acg gcg ttc tac tgg gca tgg tgg atc gca tgg act cca ttc 1219 Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe 360 365 370 gtg ggt atg ttc atc gcg cgt att tct cgc ggc cgc acc ttg cgt gaa 1267 Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu 375 380 385 ttc gcg ctc atc acc atg gct atc ccc tcc ttc att ttg atc ctg gcg 1315 Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala 390 395 400 405 ttc acc att ttc ggt gga act gcc atc acg atg aac cgc gag aac gta 1363 Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val 410 415 420 gat ggt ttt gac ggc agt tca tcc aag gaa cag gtg ctg ttt gat atg 1411 Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met 425 430 435 ttc agc aac ctt ccg ctg tac tcg atc aca ccg ttc att ttg atc ttt 1459 Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe 440 445 450 gtg ctg gca gta ttc ttt gtt acc tct gcc gat tcc gcc tcc gtg gtg 1507 Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val 455 460 465 atg gga acg atg agc tcc caa ggt aac cct gca cca aac aaa tta atc 1555 Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile 470 475 480 485 gtg gtg ttc tgg gga ctg tgc atg atg ggc atc gcg gtg gtc atg ctg 1603 Val Val Phe Trp Gly Leu Cys Met Met Gly Ile Ala Val Val Met Leu 490 495 500 ctt act ggt ggc gaa tcc gcg ctg act ggt ctg cag aac ctc acc att 1651 Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile 505 510 515 ttg atc gcc att ccg ttt gcg ctg gtg ttg atc gtg atg gct att gcc 1699 Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala 520 525 530 ttt att aag gac tta tcc aca gac cca gcc gct att cga caa cgc tat 1747 Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr 535 540 545 gca aag gca gcc atc tct aac gcg gtg gtt cgt ggc ttg gaa gaa cac 1795 Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg Gly Leu Glu Glu His 550 555 560 565 ggc gac gac ttc gag ctc tcc atc gaa cct gca gag gaa ggt cgt gga 1843 Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly 570 575 580 gcg ggt gct acc ttc gat tcc acc gct gat cac atc acc gac tgg tat 1891 Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr 585 590 595 cag cgc acc gac gaa gaa ggc aat gat gtt gat tat gac ttc acc acc 1939 Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr 600 605 610 ggc aaa tgg gcc gat ggt tgg aca ccg gaa tcg acc gaa gaa ggc gaa 1987 Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu 615 620 625 gtg gac gcg aaa aag gat taaaaaataa cgactggctg ggattcacac 2035 Val Asp Ala Lys Lys Asp 630 635 <210> 298 <211> 635 <212> PRT <213> Corynebacterium glutamicum <400> 298 Met Glu Arg Thr His Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu 1 5 10 15 Ser Gln Glu Ser Pro Glu Glu Pro His Tyr Pro His Asp Thr His Pro 20 25 30 Gly Leu Val Pro Gly Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly 35 40 45 Leu Asp Lys Thr Val Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe 50 55 60 Ile Ala Trp Gly Ile Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser 65 70 75 80 Thr Met Phe Ser Trp Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe 85 90 95 Val Met Leu Ile Gly Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg 100 105 110 Tyr Gly Arg Ile Lys Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser 115 120 125 Arg Phe Ser Trp Ile Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly 130 135 140 Ile Phe Phe Phe Gly Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro 145 150 155 160 Pro Pro His Thr Val Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala 165 170 175 Leu Ala Gln Ser His Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr 180 185 190 Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg 195 200 205 Val Thr Leu Ile Ser Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr 210 215 220 Glu Gly Ile Ala Gly Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr 225 230 235 240 Leu Phe Gly Thr Ala Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly 245 250 255 Gln Gly Val Gln Ile Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile 260 265 270 Leu Ile Ala Ile Ile Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser 275 280 285 Val Ser Gly Val Ser Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile 290 295 300 Ser Leu Thr Leu Gly Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr 305 310 315 320 Leu Phe Leu Leu Asn Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser 325 330 335 Glu Phe Leu Ser Met Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr 340 345 350 Ile Glu Phe Gln Ala Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile 355 360 365 Ala Trp Thr Pro Phe Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly 370 375 380 Arg Thr Leu Arg Glu Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe 385 390 395 400 Ile Leu Ile Leu Ala Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met 405 410 415 Asn Arg Glu Asn Val Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln 420 425 430 Val Leu Phe Asp Met Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro 435 440 445 Phe Ile Leu Ile Phe Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp 450 455 460 Ser Ala Ser Val Val Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala 465 470 475 480 Pro Asn Lys Leu Ile Val Val Phe Trp Gly Leu Cys Met Met Gly Ile 485 490 495 Ala Val Val Met Leu Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu 500 505 510 Gln Asn Leu Thr Ile Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile 515 520 525 Val Met Ala Ile Ala Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala 530 535 540 Ile Arg Gln Arg Tyr Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg 545 550 555 560 Gly Leu Glu Glu His Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala 565 570 575 Glu Glu Gly Arg Gly Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His 580 585 590 Ile Thr Asp Trp Tyr Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp 595 600 605 Tyr Asp Phe Thr Thr Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser 610 615 620 Thr Glu Glu Gly Glu Val Asp Ala Lys Lys Asp 625 630 635 <210> 299 <211> 916 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(886) <223> RXA02425 <400> 299 gtatttatca gcgtctgtgg actgcgtgga gtgtcggaag atagttgact gttcaatgcg 60 ttgaacatta gtattcatcc ctatggatac ctcgactgtg ttg ttc gca ttt gga 115 Leu Phe Ala Phe Gly 1 5 ctc acc cta ttt gcc ggt ctt gcc acc ggc atc ggc ggt ctc atc gcc 163 Leu Thr Leu Phe Ala Gly Leu Ala Thr Gly Ile Gly Gly Leu Ile Ala 10 15 20 gta gcg cgc aaa acc gtc acc gaa gga ttc ctc gca gga tca ctc ggc 211 Val Ala Arg Lys Thr Val Thr Glu Gly Phe Leu Ala Gly Ser Leu Gly 25 30 35 ttc tct gtc ggc gtg atg ctg tac gta tcc ttt gtg gaa att cta ccc 259 Phe Ser Val Gly Val Met Leu Tyr Val Ser Phe Val Glu Ile Leu Pro 40 45 50 ggc gcc ttt gat gaa tta acc agt gtt tgg gga gaa aaa ggc gga agt 307 Gly Ala Phe Asp Glu Leu Thr Ser Val Trp Gly Glu Lys Gly Gly Ser 55 60 65 tgg gcc gct gtt atc ggc ttc ttc ggt ggc atc gcg ctg atc gcc atc 355 Trp Ala Ala Val Ile Gly Phe Phe Gly Gly Ile Ala Leu Ile Ala Ile 70 75 80 85 atc gac cgc tta gtc ccc acg gcg att aac ccc cac gag ccc tcc acc 403 Ile Asp Arg Leu Val Pro Thr Ala Ile Asn Pro His Glu Pro Ser Thr 90 95 100 gtg gga ggc gcc gtt gaa gga ttc gag cgc cgc aac cgc atg atg aaa 451 Val Gly Gly Ala Val Glu Gly Phe Glu Arg Arg Asn Arg Met Met Lys 105 110 115 atg ggt gtg ctc act gcg ctg gcc atc gcg atc cac aac ttt ccc gaa 499 Met Gly Val Leu Thr Ala Leu Ala Ile Ala Ile His Asn Phe Pro Glu 120 125 130 ggt ttc gct aca ttc ttg gcc gga ttg tcc gat cca atg atc gcg atc 547 Gly Phe Ala Thr Phe Leu Ala Gly Leu Ser Asp Pro Met Ile Ala Ile 135 140 145 cct gtg gcc gtg gca att gcc att cac aat att cca gag ggc att gcg 595 Pro Val Ala Val Ala Ile Ala Ile His Asn Ile Pro Glu Gly Ile Ala 150 155 160 165 gtg gcg gtg cca ctg agg gaa gct aca ggg tca cgt cga aaa gca tta 643 Val Ala Val Pro Leu Arg Glu Ala Thr Gly Ser Arg Arg Lys Ala Leu 170 175 180 ggt tgg gcg acc ctc tcc ggc ctt gct gag ccc gcc ggc gcc ctc atc 691 Gly Trp Ala Thr Leu Ser Gly Leu Ala Glu Pro Ala Gly Ala Leu Ile 185 190 195 gga ttc ctg ctg ctc atg ccc ttt atc gga cca gaa gca ctc ggc ctg 739 Gly Phe Leu Leu Leu Met Pro Phe Ile Gly Pro Glu Ala Leu Gly Leu 200 205 210 tgc ttc gcc gca gtt gcc ggc gtg atg gtg ttc atc agc gtc gat gaa 787 Cys Phe Ala Ala Val Ala Gly Val Met Val Phe Ile Ser Val Asp Glu 215 220 225 cta ctg ccc act gcc atc tcc agc ggc aaa cac cac acc gcc atc tac 835 Leu Leu Pro Thr Ala Ile Ser Ser Gly Lys His His Thr Ala Ile Tyr 230 235 240 245 gga ctc atc gct ggc atg gca gtc atg gcg atc agc ctg ctg ctg ttt 883 Gly Leu Ile Ala Gly Met Ala Val Met Ala Ile Ser Leu Leu Leu Phe 250 255 260 atc tagcgttcag ccgcaacaag catccggtca 916 Ile <210> 300 <211> 262 <212> PRT <213> Corynebacterium glutamicum <400> 300 Leu Phe Ala Phe Gly Leu Thr Leu Phe Ala Gly Leu Ala Thr Gly Ile 1 5 10 15 Gly Gly Leu Ile Ala Val Ala Arg Lys Thr Val Thr Glu Gly Phe Leu 20 25 30 Ala Gly Ser Leu Gly Phe Ser Val Gly Val Met Leu Tyr Val Ser Phe 35 40 45 Val Glu Ile Leu Pro Gly Ala Phe Asp Glu Leu Thr Ser Val Trp Gly 50 55 60 Glu Lys Gly Gly Ser Trp Ala Ala Val Ile Gly Phe Phe Gly Gly Ile 65 70 75 80 Ala Leu Ile Ala Ile Ile Asp Arg Leu Val Pro Thr Ala Ile Asn Pro 85 90 95 His Glu Pro Ser Thr Val Gly Gly Ala Val Glu Gly Phe Glu Arg Arg 100 105 110 Asn Arg Met Met Lys Met Gly Val Leu Thr Ala Leu Ala Ile Ala Ile 115 120 125 His Asn Phe Pro Glu Gly Phe Ala Thr Phe Leu Ala Gly Leu Ser Asp 130 135 140 Pro Met Ile Ala Ile Pro Val Ala Val Ala Ile Ala Ile His Asn Ile 145 150 155 160 Pro Glu Gly Ile Ala Val Ala Val Pro Leu Arg Glu Ala Thr Gly Ser 165 170 175 Arg Arg Lys Ala Leu Gly Trp Ala Thr Leu Ser Gly Leu Ala Glu Pro 180 185 190 Ala Gly Ala Leu Ile Gly Phe Leu Leu Leu Met Pro Phe Ile Gly Pro 195 200 205 Glu Ala Leu Gly Leu Cys Phe Ala Ala Val Ala Gly Val Met Val Phe 210 215 220 Ile Ser Val Asp Glu Leu Leu Pro Thr Ala Ile Ser Ser Gly Lys His 225 230 235 240 His Thr Ala Ile Tyr Gly Leu Ile Ala Gly Met Ala Val Met Ala Ile 245 250 255 Ser Leu Leu Leu Phe Ile 260 <210> 301 <211> 682 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(652) <223> RXA02433 <400> 301 atgctgatag atatttggtg accagagatt agagcaaagg atcattttca tcgtgaagct 60 tttcaaggca accgcagtta cttttactgt tgcagcagca ttg gcg ctc agc gcg 115 Leu Ala Leu Ser Ala 1 5 tgc tcc agc agt gat gat tcc tct tcg gag tca agc acc tct tct tcc 163 Cys Ser Ser Ser Asp Asp Ser Ser Ser Glu Ser Ser Thr Ser Ser Ser 10 15 20 acc tct tcg gct gcg tct gat gct gcg act cag tac cca act gct gag 211 Thr Ser Ser Ala Ala Ser Asp Ala Ala Thr Gln Tyr Pro Thr Ala Glu 25 30 35 gaa ctg aat gca att ttg gct gtg gca acc gac cct gag gca cca atc 259 Glu Leu Asn Ala Ile Leu Ala Val Ala Thr Asp Pro Glu Ala Pro Ile 40 45 50 gag gag aag gtg aag act gtt cag ggt tct gag aac gct cct gag ctg 307 Glu Glu Lys Val Lys Thr Val Gln Gly Ser Glu Asn Ala Pro Glu Leu 55 60 65 ttt gag acc atg act cag gca aag gtg gag tcg ggt gct gag ttc cag 355 Phe Glu Thr Met Thr Gln Ala Lys Val Glu Ser Gly Ala Glu Phe Gln 70 75 80 85 gtt gtt ggt tct gtg ctt cct ggc tat gac cca acc tct gag gtt ctg 403 Val Val Gly Ser Val Leu Pro Gly Tyr Asp Pro Thr Ser Glu Val Leu 90 95 100 acc acc gtc atg ttc cag ctt ccg gac cgc gct gag cag gaa gct gaa 451 Thr Thr Val Met Phe Gln Leu Pro Asp Arg Ala Glu Gln Glu Ala Glu 105 110 115 ggc gtg gag ttt gtg aac act gat ggt aat tgg cag ctg tcc cag gat 499 Gly Val Glu Phe Val Asn Thr Asp Gly Asn Trp Gln Leu Ser Gln Asp 120 125 130 tgg gct tgt atc ttg atc acc aat act gtt gct cct gag cag gtt cct 547 Trp Ala Cys Ile Leu Ile Thr Asn Thr Val Ala Pro Glu Gln Val Pro 135 140 145 gca atg tgt gtt gga act gat gct tct tcc gct ggt att gaa gag gcc 595 Ala Met Cys Val Gly Thr Asp Ala Ser Ser Ala Gly Ile Glu Glu Ala 150 155 160 165 cca gct gaa gag ggt gct gtt gtt gag gaa gcc cct gtt gaa gag gtt 643 Pro Ala Glu Glu Gly Ala Val Val Glu Glu Ala Pro Val Glu Glu Val 170 175 180 cct gtt cag tagggtttaa cggctcaggc tgattttctt 682 Pro Val Gln <210> 302 <211> 184 <212> PRT <213> Corynebacterium glutamicum <400> 302 Leu Ala Leu Ser Ala Cys Ser Ser Ser Asp Asp Ser Ser Ser Glu Ser 1 5 10 15 Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ser Asp Ala Ala Thr Gln 20 25 30 Tyr Pro Thr Ala Glu Glu Leu Asn Ala Ile Leu Ala Val Ala Thr Asp 35 40 45 Pro Glu Ala Pro Ile Glu Glu Lys Val Lys Thr Val Gln Gly Ser Glu 50 55 60 Asn Ala Pro Glu Leu Phe Glu Thr Met Thr Gln Ala Lys Val Glu Ser 65 70 75 80 Gly Ala Glu Phe Gln Val Val Gly Ser Val Leu Pro Gly Tyr Asp Pro 85 90 95 Thr Ser Glu Val Leu Thr Thr Val Met Phe Gln Leu Pro Asp Arg Ala 100 105 110 Glu Gln Glu Ala Glu Gly Val Glu Phe Val Asn Thr Asp Gly Asn Trp 115 120 125 Gln Leu Ser Gln Asp Trp Ala Cys Ile Leu Ile Thr Asn Thr Val Ala 130 135 140 Pro Glu Gln Val Pro Ala Met Cys Val Gly Thr Asp Ala Ser Ser Ala 145 150 155 160 Gly Ile Glu Glu Ala Pro Ala Glu Glu Gly Ala Val Val Glu Glu Ala 165 170 175 Pro Val Glu Glu Val Pro Val Gln 180 <210> 303 <211> 766 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(736) <223> RXA02486 <400> 303 tccgacctcg tcgcattagc caaagaaatc cgcgacggag tcctcgaaac cttcggcgtc 60 accctcgtcc cagaacccgt ctggattgga atcagcatcg atg act gaa ttt tcc 115 Met Thr Glu Phe Ser 1 5 gac gtc cct ggc acc gcc gcc cca ctg cac agg gcg ttg gaa aat gcc 163 Asp Val Pro Gly Thr Ala Ala Pro Leu His Arg Ala Leu Glu Asn Ala 10 15 20 gga tac tcc act tta gaa tcc ctc gac ggt gtt ccc tac aag acg ttg 211 Gly Tyr Ser Thr Leu Glu Ser Leu Asp Gly Val Pro Tyr Lys Thr Leu 25 30 35 att gcc ctg cat ggt gtc gga aaa act ggc ctc ggc agg atc cag gca 259 Ile Ala Leu His Gly Val Gly Lys Thr Gly Leu Gly Arg Ile Gln Ala 40 45 50 gca ttg ttg gaa cgt ggc ctt tcc ctg ggg gaa gaa aca aaa ggc gcc 307 Ala Leu Leu Glu Arg Gly Leu Ser Leu Gly Glu Glu Thr Lys Gly Ala 55 60 65 acc atc acc cca ggt cac acc ggt aaa gtg gcc tca gat atc aaa act 355 Thr Ile Thr Pro Gly His Thr Gly Lys Val Ala Ser Asp Ile Lys Thr 70 75 80 85 cac atc act tcc gtg gat ccc gtc gca tac gtc gat ggt cta gag ggg 403 His Ile Thr Ser Val Asp Pro Val Ala Tyr Val Asp Gly Leu Glu Gly 90 95 100 cgt cgg gtt gct cac ggg cac caa ttg cta tcg atc ttc ggt cgc gtc 451 Arg Arg Val Ala His Gly His Gln Leu Leu Ser Ile Phe Gly Arg Val 105 110 115 acc ggc gcg gaa ccc aaa atg tgg gga ccc tcc atg atc gga tac ggc 499 Thr Gly Ala Glu Pro Lys Met Trp Gly Pro Ser Met Ile Gly Tyr Gly 120 125 130 tca gtc cac tac gtt tcc cac acc gga agg gaa ggc gat tgg ttt cag 547 Ser Val His Tyr Val Ser His Thr Gly Arg Glu Gly Asp Trp Phe Gln 135 140 145 tgt ggt ttc agc ccg gcg aag tcc aaa atc tgc ctg tat ggc ctg aag 595 Cys Gly Phe Ser Pro Ala Lys Ser Lys Ile Cys Leu Tyr Gly Leu Lys 150 155 160 165 gat tcg cct cgc ggt gag gaa ttg ctg cag aaa ctt gga aaa tac acc 643 Asp Ser Pro Arg Gly Glu Glu Leu Leu Gln Lys Leu Gly Lys Tyr Thr 170 175 180 gaa ggc cgc gga tgc gtg tac atc aat aaa ccg gaa gac atc gat ttg 691 Glu Gly Arg Gly Cys Val Tyr Ile Asn Lys Pro Glu Asp Ile Asp Leu 185 190 195 gat gtt tta gag gcc atg atc agc gag tca tgg gcc ggc caa ggc 736 Asp Val Leu Glu Ala Met Ile Ser Glu Ser Trp Ala Gly Gln Gly 200 205 210 taggttgcaa atccccacca caagttgctc 766 <210> 304 <211> 212 <212> PRT <213> Corynebacterium glutamicum <400> 304 Met Thr Glu Phe Ser Asp Val Pro Gly Thr Ala Ala Pro Leu His Arg 1 5 10 15 Ala Leu Glu Asn Ala Gly Tyr Ser Thr Leu Glu Ser Leu Asp Gly Val 20 25 30 Pro Tyr Lys Thr Leu Ile Ala Leu His Gly Val Gly Lys Thr Gly Leu 35 40 45 Gly Arg Ile Gln Ala Ala Leu Leu Glu Arg Gly Leu Ser Leu Gly Glu 50 55 60 Glu Thr Lys Gly Ala Thr Ile Thr Pro Gly His Thr Gly Lys Val Ala 65 70 75 80 Ser Asp Ile Lys Thr His Ile Thr Ser Val Asp Pro Val Ala Tyr Val 85 90 95 Asp Gly Leu Glu Gly Arg Arg Val Ala His Gly His Gln Leu Leu Ser 100 105 110 Ile Phe Gly Arg Val Thr Gly Ala Glu Pro Lys Met Trp Gly Pro Ser 115 120 125 Met Ile Gly Tyr Gly Ser Val His Tyr Val Ser His Thr Gly Arg Glu 130 135 140 Gly Asp Trp Phe Gln Cys Gly Phe Ser Pro Ala Lys Ser Lys Ile Cys 145 150 155 160 Leu Tyr Gly Leu Lys Asp Ser Pro Arg Gly Glu Glu Leu Leu Gln Lys 165 170 175 Leu Gly Lys Tyr Thr Glu Gly Arg Gly Cys Val Tyr Ile Asn Lys Pro 180 185 190 Glu Asp Ile Asp Leu Asp Val Leu Glu Ala Met Ile Ser Glu Ser Trp 195 200 205 Ala Gly Gln Gly 210 <210> 305 <211> 1087 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1057) <223> RXA02488 <400> 305 taaggttacc ctaccctctt tggggtaggg ctcttccatt tttgccaggt taggttaagc 60 taatctagtt tttattgcgt tatcgaacag gagaacaaaa atg aac aag ctt gcc 115 Met Asn Lys Leu Ala 1 5 acc cgt gcg ctc gtt gct ctc acg gga tcc gcc atc gcc atg acc ggc 163 Thr Arg Ala Leu Val Ala Leu Thr Gly Ser Ala Ile Ala Met Thr Gly 10 15 20 ctc acc gta gtc tcg gct aat gca gcc gag aaa acc ggc aaa tgc cgc 211 Leu Thr Val Val Ser Ala Asn Ala Ala Glu Lys Thr Gly Lys Cys Arg 25 30 35 gtt gtc acc acc aca gga acc gcc gac tgg tca gtg cgt gaa tca ttc 259 Val Val Thr Thr Thr Gly Thr Ala Asp Trp Ser Val Arg Glu Ser Phe 40 45 50 aac aac tac ctt gaa ggt cca att gca aac ggt gca gca tac aaa tac 307 Asn Asn Tyr Leu Glu Gly Pro Ile Ala Asn Gly Ala Ala Tyr Lys Tyr 55 60 65 cac ggt ggc atc gag gtc cgt gac ggt gta gaa acc acc ggc acg aag 355 His Gly Gly Ile Glu Val Arg Asp Gly Val Glu Thr Thr Gly Thr Lys 70 75 80 85 tca gct cgc gag ttc acc tgg cca gta ctt ggc agc gaa gaa gga gcc 403 Ser Ala Arg Glu Phe Thr Trp Pro Val Leu Gly Ser Glu Glu Gly Ala 90 95 100 gtc aaa ctt ggc ggt ggc gtt cac tgg acc gga cac aat cac tac tcc 451 Val Lys Leu Gly Gly Gly Val His Trp Thr Gly His Asn His Tyr Ser 105 110 115 ggc gac gac gag tcc cag gcg cca gac aac ttc atc ctt gat ctc gac 499 Gly Asp Asp Glu Ser Gln Ala Pro Asp Asn Phe Ile Leu Asp Leu Asp 120 125 130 ttc tcc aac cca acc gtc aaa ttc gat ggc aac gag ggc acc ctg ctt 547 Phe Ser Asn Pro Thr Val Lys Phe Asp Gly Asn Glu Gly Thr Leu Leu 135 140 145 gtc gac ttc aag tcc cgt gag ttc gtt gat acc aag acc gtc gct gac 595 Val Asp Phe Lys Ser Arg Glu Phe Val Asp Thr Lys Thr Val Ala Asp 150 155 160 165 ttc ctc acc gga act cag gca gag ttg gct acc atc act ttc gat gag 643 Phe Leu Thr Gly Thr Gln Ala Glu Leu Ala Thr Ile Thr Phe Asp Glu 170 175 180 cca atc gac ctg acc cag gag aac gtc acc gtc acc ggc cag acc aag 691 Pro Ile Asp Leu Thr Gln Glu Asn Val Thr Val Thr Gly Gln Thr Lys 185 190 195 ctg act gca act ggt gtc gat gtc atg ggc acc ttc tac cca gaa ggt 739 Leu Thr Ala Thr Gly Val Asp Val Met Gly Thr Phe Tyr Pro Glu Gly 200 205 210 gaa gca ctt gcg cca atc act ttg aac ctc acc aac gaa gtt gta tgc 787 Glu Ala Leu Ala Pro Ile Thr Leu Asn Leu Thr Asn Glu Val Val Cys 215 220 225 gac gag cct gaa acc ccc gtt gag cct gag gtt cct gta gag cct gag 835 Asp Glu Pro Glu Thr Pro Val Glu Pro Glu Val Pro Val Glu Pro Glu 230 235 240 245 act cca gta gat ccg gaa acc tcg gtc gac cca gag act cca gta gat 883 Thr Pro Val Asp Pro Glu Thr Ser Val Asp Pro Glu Thr Pro Val Asp 250 255 260 ccg gaa acc tcg gtc gac cca gaa aag cct ggc gat gac aac aag gat 931 Pro Glu Thr Ser Val Asp Pro Glu Lys Pro Gly Asp Asp Asn Lys Asp 265 270 275 gac gga agc aac agc agc agc aac ggc gat atc ctc gga atc ttg ggc 979 Asp Gly Ser Asn Ser Ser Ser Asn Gly Asp Ile Leu Gly Ile Leu Gly 280 285 290 atc ctc gca gcg ctt ggt ggc gtt ggt gca ctt gtg tac aac ttc ctg 1027 Ile Leu Ala Ala Leu Gly Gly Val Gly Ala Leu Val Tyr Asn Phe Leu 295 300 305 gta gct agc gga ttc ctt gca gcg ttt aag taaatgaatc gttttcctag 1077 Val Ala Ser Gly Phe Leu Ala Ala Phe Lys 310 315 tgccttatta 1087 <210> 306 <211> 319 <212> PRT <213> Corynebacterium glutamicum <400> 306 Met Asn Lys Leu Ala Thr Arg Ala Leu Val Ala Leu Thr Gly Ser Ala 1 5 10 15 Ile Ala Met Thr Gly Leu Thr Val Val Ser Ala Asn Ala Ala Glu Lys 20 25 30 Thr Gly Lys Cys Arg Val Val Thr Thr Thr Gly Thr Ala Asp Trp Ser 35 40 45 Val Arg Glu Ser Phe Asn Asn Tyr Leu Glu Gly Pro Ile Ala Asn Gly 50 55 60 Ala Ala Tyr Lys Tyr His Gly Gly Ile Glu Val Arg Asp Gly Val Glu 65 70 75 80 Thr Thr Gly Thr Lys Ser Ala Arg Glu Phe Thr Trp Pro Val Leu Gly 85 90 95 Ser Glu Glu Gly Ala Val Lys Leu Gly Gly Gly Val His Trp Thr Gly 100 105 110 His Asn His Tyr Ser Gly Asp Asp Glu Ser Gln Ala Pro Asp Asn Phe 115 120 125 Ile Leu Asp Leu Asp Phe Ser Asn Pro Thr Val Lys Phe Asp Gly Asn 130 135 140 Glu Gly Thr Leu Leu Val Asp Phe Lys Ser Arg Glu Phe Val Asp Thr 145 150 155 160 Lys Thr Val Ala Asp Phe Leu Thr Gly Thr Gln Ala Glu Leu Ala Thr 165 170 175 Ile Thr Phe Asp Glu Pro Ile Asp Leu Thr Gln Glu Asn Val Thr Val 180 185 190 Thr Gly Gln Thr Lys Leu Thr Ala Thr Gly Val Asp Val Met Gly Thr 195 200 205 Phe Tyr Pro Glu Gly Glu Ala Leu Ala Pro Ile Thr Leu Asn Leu Thr 210 215 220 Asn Glu Val Val Cys Asp Glu Pro Glu Thr Pro Val Glu Pro Glu Val 225 230 235 240 Pro Val Glu Pro Glu Thr Pro Val Asp Pro Glu Thr Ser Val Asp Pro 245 250 255 Glu Thr Pro Val Asp Pro Glu Thr Ser Val Asp Pro Glu Lys Pro Gly 260 265 270 Asp Asp Asn Lys Asp Asp Gly Ser Asn Ser Ser Ser Asn Gly Asp Ile 275 280 285 Leu Gly Ile Leu Gly Ile Leu Ala Ala Leu Gly Gly Val Gly Ala Leu 290 295 300 Val Tyr Asn Phe Leu Val Ala Ser Gly Phe Leu Ala Ala Phe Lys 305 310 315 <210> 307 <211> 2716 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2686) <223> RXA02495 <400> 307 aactttaagg agttcaccaa ggaggaaaat tatcaccgtc ttaaaaacgg ctaaggcttt 60 tctaaattcg ccgctgcgca ccatcacgtg gcgcagcgtt gtg gcg aat aaa ctc 115 Val Ala Asn Lys Leu 1 5 cgc atg gca tta aca gtg ctt tcg gtt gtg cta gga acc gca ttt ttg 163 Arg Met Ala Leu Thr Val Leu Ser Val Val Leu Gly Thr Ala Phe Leu 10 15 20 tgt ggc tcc ctc ctc ctc aca cat tcc ctt gaa aga aca ttt tcc tcc 211 Cys Gly Ser Leu Leu Leu Thr His Ser Leu Glu Arg Thr Phe Ser Ser 25 30 35 atc gtt gat gcc ggc gtg gag ggc gtt gac gtg ggc gtt atc gcg caa 259 Ile Val Asp Ala Gly Val Glu Gly Val Asp Val Gly Val Ile Ala Gln 40 45 50 caa aac aac ccc gac ggc gta cct ttc tcc gtc atc gcc gaa att gag 307 Gln Asn Asn Pro Asp Gly Val Pro Phe Ser Val Ile Ala Glu Ile Glu 55 60 65 cag tat ccg gaa gtc cgc gcc gtc aac atc atc ggc gac ggc ccc ggc 355 Gln Tyr Pro Glu Val Arg Ala Val Asn Ile Ile Gly Asp Gly Pro Gly 70 75 80 85 atg ccc tcc ggc acc acc atg acc ggc caa tcc gcg ctg atc ctc acc 403 Met Pro Ser Gly Thr Thr Met Thr Gly Gln Ser Ala Leu Ile Leu Thr 90 95 100 gac tcc gac ggc aat ccc ctg caa gca ggc agc tcc ggc acg cac ccg 451 Asp Ser Asp Gly Asn Pro Leu Gln Ala Gly Ser Ser Gly Thr His Pro 105 110 115 cta gcc att tat ccg cag ggc gag tgg gtc tcg ccc gag cca acg ctt 499 Leu Ala Ile Tyr Pro Gln Gly Glu Trp Val Ser Pro Glu Pro Thr Leu 120 125 130 atc gac ggc cac ttc ccc aca aaa ccc gac gag gta gta gtc aac gct 547 Ile Asp Gly His Phe Pro Thr Lys Pro Asp Glu Val Val Val Asn Ala 135 140 145 tcg gcc gcc aaa cgt ggc ggg ctc tcc ctc ggt gat cac cta acg atc 595 Ser Ala Ala Lys Arg Gly Gly Leu Ser Leu Gly Asp His Leu Thr Ile 150 155 160 165 gtc aca ccc acc gaa cgc atc gac gcc acc ctg tct gga acc ttc gaa 643 Val Thr Pro Thr Glu Arg Ile Asp Ala Thr Leu Ser Gly Thr Phe Glu 170 175 180 tca aac acc gac gtc gca ggc tgg gtc gga gtc gga ttc acc cca cag 691 Ser Asn Thr Asp Val Ala Gly Trp Val Gly Val Gly Phe Thr Pro Gln 185 190 195 cgc tac gtc gaa ctg ttc acc aac ggc acc gac gcc agc caa atc acc 739 Arg Tyr Val Glu Leu Phe Thr Asn Gly Thr Asp Ala Ser Gln Ile Thr 200 205 210 atc gca gtc aac gac ggc gcc gac ccc atg gca gtc cgc aac cgc atc 787 Ile Ala Val Asn Asp Gly Ala Asp Pro Met Ala Val Arg Asn Arg Ile 215 220 225 ggc aaa aac cac cgc gac ctc ctg ccc ctg ctg ccc gag caa atc atc 835 Gly Lys Asn His Arg Asp Leu Leu Pro Leu Leu Pro Glu Gln Ile Ile 230 235 240 245 gac caa acc acc ggc gac acc gcc cgc caa ctg gag ttc atg acc tac 883 Asp Gln Thr Thr Gly Asp Thr Ala Arg Gln Leu Glu Phe Met Thr Tyr 250 255 260 gtg ctc ctg gca ttc gcc gcg atc gca ctg att gtt ggc tcg ttc atc 931 Val Leu Leu Ala Phe Ala Ala Ile Ala Leu Ile Val Gly Ser Phe Ile 265 270 275 att gcc aac acc ttc gcg atg atc gtc gcc caa cgc acc ggc gaa ttc 979 Ile Ala Asn Thr Phe Ala Met Ile Val Ala Gln Arg Thr Gly Glu Phe 280 285 290 gcc ctc ctc cgt tcc att ggt gtc tcc acg ttc caa atc gga ttc tcc 1027 Ala Leu Leu Arg Ser Ile Gly Val Ser Thr Phe Gln Ile Gly Phe Ser 295 300 305 gtg att atg gaa gca gta ttc gtc gga ctt atc ggc ggt ttc atc ggc 1075 Val Ile Met Glu Ala Val Phe Val Gly Leu Ile Gly Gly Phe Ile Gly 310 315 320 325 atc gca gtt ggc ttc gga gtg gtc aat gca ctt gtc caa gtg ctc aac 1123 Ile Ala Val Gly Phe Gly Val Val Asn Ala Leu Val Gln Val Leu Asn 330 335 340 caa ttc ggc gac acc ctc tcc tcc atc gac atc acc tac aac gcc gga 1171 Gln Phe Gly Asp Thr Leu Ser Ser Ile Asp Ile Thr Tyr Asn Ala Gly 345 350 355 tcc ttc atc ttc cct gtc ctc ttc gcc gtc act gcc acc gta cta agc 1219 Ser Phe Ile Phe Pro Val Leu Phe Ala Val Thr Ala Thr Val Leu Ser 360 365 370 tcc ata tcg cct gct cac cgc gcc ggt aac ctc cca cca gtc caa gca 1267 Ser Ile Ser Pro Ala His Arg Ala Gly Asn Leu Pro Pro Val Gln Ala 375 380 385 ttc gaa tcc tcc gat gca cgc agc gac gcc ctc gga agg atc cgc ttc 1315 Phe Glu Ser Ser Asp Ala Arg Ser Asp Ala Leu Gly Arg Ile Arg Phe 390 395 400 405 ctc gtc gcc gcc gtc atg ctc acc ctt gga atc agc ctg acg atc gca 1363 Leu Val Ala Ala Val Met Leu Thr Leu Gly Ile Ser Leu Thr Ile Ala 410 415 420 ggt gcc gtg gta tcc gcc atc aac gga gat gaa ttc aaa aca gaa aca 1411 Gly Ala Val Val Ser Ala Ile Asn Gly Asp Glu Phe Lys Thr Glu Thr 425 430 435 cgc ctc gca ttc atc ggc gct gga ctt ctc tta gtg ttc ttc tca ctc 1459 Arg Leu Ala Phe Ile Gly Ala Gly Leu Leu Leu Val Phe Phe Ser Leu 440 445 450 tcc ctg tcc ggt ccc gca ctg atg gtg gcg acc tct cag act ctt ggc 1507 Ser Leu Ser Gly Pro Ala Leu Met Val Ala Thr Ser Gln Thr Leu Gly 455 460 465 gtg gcg ata atg tcg ccg ttc cga gcc gtc ggc aag ctc gca caa cgc 1555 Val Ala Ile Met Ser Pro Phe Arg Ala Val Gly Lys Leu Ala Gln Arg 470 475 480 485 aac acc ctg cgc aat ccg cga cgc tcc gca acc acc gca ctg gcc gtc 1603 Asn Thr Leu Arg Asn Pro Arg Arg Ser Ala Thr Thr Ala Leu Ala Val 490 495 500 act ttg agc gtt ggc ctc gtc gcc tgc gtt gga gtc atc ggc gcc acc 1651 Thr Leu Ser Val Gly Leu Val Ala Cys Val Gly Val Ile Gly Ala Thr 505 510 515 acc cgc gcc agc gtc ttc ggg tcc atg gaa tcc acc atc aaa tcc cca 1699 Thr Arg Ala Ser Val Phe Gly Ser Met Glu Ser Thr Ile Lys Ser Pro 520 525 530 tat gtc ctc gac agc atc ggt ggc acc atg atc cct gga caa ccc gcc 1747 Tyr Val Leu Asp Ser Ile Gly Gly Thr Met Ile Pro Gly Gln Pro Ala 535 540 545 ggc ggt tca agg tca ctg tcc atg tcc gca gcc gtc gca cag gaa atc 1795 Gly Gly Ser Arg Ser Leu Ser Met Ser Ala Ala Val Ala Gln Glu Ile 550 555 560 565 gca caa acc cgc gga gtc ggc aaa gtg ggc acc ctc atg acc ggc agc 1843 Ala Gln Thr Arg Gly Val Gly Lys Val Gly Thr Leu Met Thr Gly Ser 570 575 580 gtc caa gtc aac gga tgg gac aac gaa aac acc aca att ttc gac ggc 1891 Val Gln Val Asn Gly Trp Asp Asn Glu Asn Thr Thr Ile Phe Asp Gly 585 590 595 gac ctc tct cag ttc ctc gac ctc gca gtc cgc tcc ggc gac gcc ttc 1939 Asp Leu Ser Gln Phe Leu Asp Leu Ala Val Arg Ser Gly Asp Ala Phe 600 605 610 gac gac gaa acc ccc ggc gtc atg atc tcc acc acc tac gcc gac caa 1987 Asp Asp Glu Thr Pro Gly Val Met Ile Ser Thr Thr Tyr Ala Asp Gln 615 620 625 tcc gac ctc gaa gta ggc gac acc gtc acc gtc aac ccc tac gga tcc 2035 Ser Asp Leu Glu Val Gly Asp Thr Val Thr Val Asn Pro Tyr Gly Ser 630 635 640 645 gac gac ggc atc cgc gtc ccc atc acc ggc atc tac gca gaa acc aac 2083 Asp Asp Gly Ile Arg Val Pro Ile Thr Gly Ile Tyr Ala Glu Thr Asn 650 655 660 ctc gtc gga cac ctc atg gtc aac gca gcc gcc acc aac cga gtc ctc 2131 Leu Val Gly His Leu Met Val Asn Ala Ala Ala Thr Asn Arg Val Leu 665 670 675 acc tcc gcg gac acc tac cac cgg tcc caa atc ttc gtc aac ggc gac 2179 Thr Ser Ala Asp Thr Tyr His Arg Ser Gln Ile Phe Val Asn Gly Asp 680 685 690 ggc tcc acc acc aac gaa gaa ctc cgc gac atc ctc gtc gac gcc gta 2227 Gly Ser Thr Thr Asn Glu Glu Leu Arg Asp Ile Leu Val Asp Ala Val 695 700 705 gcc ccc ttc ctc atc gtc caa gtg aaa tcc aaa gat gaa ttc cgc gga 2275 Ala Pro Phe Leu Ile Val Gln Val Lys Ser Lys Asp Glu Phe Arg Gly 710 715 720 725 agc ctc ggc acc caa atc aac caa ttg ctc ggc atc atc tac gga ctg 2323 Ser Leu Gly Thr Gln Ile Asn Gln Leu Leu Gly Ile Ile Tyr Gly Leu 730 735 740 ctc gcc ctg gca gtg atc atc gca gtc ctg gga atc gtc aac aca ctg 2371 Leu Ala Leu Ala Val Ile Ile Ala Val Leu Gly Ile Val Asn Thr Leu 745 750 755 ttc ctc tcc atc agc gaa cgc acc cgc gaa atc gga atc ctc cgc gcc 2419 Phe Leu Ser Ile Ser Glu Arg Thr Arg Glu Ile Gly Ile Leu Arg Ala 760 765 770 acc ggc gtc caa cga gga caa atc cgc cgc atg att acc ctc gaa tcc 2467 Thr Gly Val Gln Arg Gly Gln Ile Arg Arg Met Ile Thr Leu Glu Ser 775 780 785 gtc atc ctc tcc atc cac ggc gca atc cac gga ctc ctc cta ggt aca 2515 Val Ile Leu Ser Ile His Gly Ala Ile His Gly Leu Leu Leu Gly Thr 790 795 800 805 ttt atc ggc tgg gca atc gtc agt tgt ctc cgc acc cga ggc atg gca 2563 Phe Ile Gly Trp Ala Ile Val Ser Cys Leu Arg Thr Arg Gly Met Ala 810 815 820 ccc gtc gaa ttc ccc tgg acc caa atc gga tta atg ctc atc tcc gca 2611 Pro Val Glu Phe Pro Trp Thr Gln Ile Gly Leu Met Leu Ile Ser Ala 825 830 835 atc atc atc gga ggc ata gca gcc ctc atc cca gcc aac cga gcc tcc 2659 Ile Ile Ile Gly Gly Ile Ala Ala Leu Ile Pro Ala Asn Arg Ala Ser 840 845 850 cga atc tcc cct ttg gaa gca atc aac taacagtctg catcggcaac 2706 Arg Ile Ser Pro Leu Glu Ala Ile Asn 855 860 ctcctcttac 2716 <210> 308 <211> 862 <212> PRT <213> Corynebacterium glutamicum <400> 308 Val Ala Asn Lys Leu Arg Met Ala Leu Thr Val Leu Ser Val Val Leu 1 5 10 15 Gly Thr Ala Phe Leu Cys Gly Ser Leu Leu Leu Thr His Ser Leu Glu 20 25 30 Arg Thr Phe Ser Ser Ile Val Asp Ala Gly Val Glu Gly Val Asp Val 35 40 45 Gly Val Ile Ala Gln Gln Asn Asn Pro Asp Gly Val Pro Phe Ser Val 50 55 60 Ile Ala Glu Ile Glu Gln Tyr Pro Glu Val Arg Ala Val Asn Ile Ile 65 70 75 80 Gly Asp Gly Pro Gly Met Pro Ser Gly Thr Thr Met Thr Gly Gln Ser 85 90 95 Ala Leu Ile Leu Thr Asp Ser Asp Gly Asn Pro Leu Gln Ala Gly Ser 100 105 110 Ser Gly Thr His Pro Leu Ala Ile Tyr Pro Gln Gly Glu Trp Val Ser 115 120 125 Pro Glu Pro Thr Leu Ile Asp Gly His Phe Pro Thr Lys Pro Asp Glu 130 135 140 Val Val Val Asn Ala Ser Ala Ala Lys Arg Gly Gly Leu Ser Leu Gly 145 150 155 160 Asp His Leu Thr Ile Val Thr Pro Thr Glu Arg Ile Asp Ala Thr Leu 165 170 175 Ser Gly Thr Phe Glu Ser Asn Thr Asp Val Ala Gly Trp Val Gly Val 180 185 190 Gly Phe Thr Pro Gln Arg Tyr Val Glu Leu Phe Thr Asn Gly Thr Asp 195 200 205 Ala Ser Gln Ile Thr Ile Ala Val Asn Asp Gly Ala Asp Pro Met Ala 210 215 220 Val Arg Asn Arg Ile Gly Lys Asn His Arg Asp Leu Leu Pro Leu Leu 225 230 235 240 Pro Glu Gln Ile Ile Asp Gln Thr Thr Gly Asp Thr Ala Arg Gln Leu 245 250 255 Glu Phe Met Thr Tyr Val Leu Leu Ala Phe Ala Ala Ile Ala Leu Ile 260 265 270 Val Gly Ser Phe Ile Ile Ala Asn Thr Phe Ala Met Ile Val Ala Gln 275 280 285 Arg Thr Gly Glu Phe Ala Leu Leu Arg Ser Ile Gly Val Ser Thr Phe 290 295 300 Gln Ile Gly Phe Ser Val Ile Met Glu Ala Val Phe Val Gly Leu Ile 305 310 315 320 Gly Gly Phe Ile Gly Ile Ala Val Gly Phe Gly Val Val Asn Ala Leu 325 330 335 Val Gln Val Leu Asn Gln Phe Gly Asp Thr Leu Ser Ser Ile Asp Ile 340 345 350 Thr Tyr Asn Ala Gly Ser Phe Ile Phe Pro Val Leu Phe Ala Val Thr 355 360 365 Ala Thr Val Leu Ser Ser Ile Ser Pro Ala His Arg Ala Gly Asn Leu 370 375 380 Pro Pro Val Gln Ala Phe Glu Ser Ser Asp Ala Arg Ser Asp Ala Leu 385 390 395 400 Gly Arg Ile Arg Phe Leu Val Ala Ala Val Met Leu Thr Leu Gly Ile 405 410 415 Ser Leu Thr Ile Ala Gly Ala Val Val Ser Ala Ile Asn Gly Asp Glu 420 425 430 Phe Lys Thr Glu Thr Arg Leu Ala Phe Ile Gly Ala Gly Leu Leu Leu 435 440 445 Val Phe Phe Ser Leu Ser Leu Ser Gly Pro Ala Leu Met Val Ala Thr 450 455 460 Ser Gln Thr Leu Gly Val Ala Ile Met Ser Pro Phe Arg Ala Val Gly 465 470 475 480 Lys Leu Ala Gln Arg Asn Thr Leu Arg Asn Pro Arg Arg Ser Ala Thr 485 490 495 Thr Ala Leu Ala Val Thr Leu Ser Val Gly Leu Val Ala Cys Val Gly 500 505 510 Val Ile Gly Ala Thr Thr Arg Ala Ser Val Phe Gly Ser Met Glu Ser 515 520 525 Thr Ile Lys Ser Pro Tyr Val Leu Asp Ser Ile Gly Gly Thr Met Ile 530 535 540 Pro Gly Gln Pro Ala Gly Gly Ser Arg Ser Leu Ser Met Ser Ala Ala 545 550 555 560 Val Ala Gln Glu Ile Ala Gln Thr Arg Gly Val Gly Lys Val Gly Thr 565 570 575 Leu Met Thr Gly Ser Val Gln Val Asn Gly Trp Asp Asn Glu Asn Thr 580 585 590 Thr Ile Phe Asp Gly Asp Leu Ser Gln Phe Leu Asp Leu Ala Val Arg 595 600 605 Ser Gly Asp Ala Phe Asp Asp Glu Thr Pro Gly Val Met Ile Ser Thr 610 615 620 Thr Tyr Ala Asp Gln Ser Asp Leu Glu Val Gly Asp Thr Val Thr Val 625 630 635 640 Asn Pro Tyr Gly Ser Asp Asp Gly Ile Arg Val Pro Ile Thr Gly Ile 645 650 655 Tyr Ala Glu Thr Asn Leu Val Gly His Leu Met Val Asn Ala Ala Ala 660 665 670 Thr Asn Arg Val Leu Thr Ser Ala Asp Thr Tyr His Arg Ser Gln Ile 675 680 685 Phe Val Asn Gly Asp Gly Ser Thr Thr Asn Glu Glu Leu Arg Asp Ile 690 695 700 Leu Val Asp Ala Val Ala Pro Phe Leu Ile Val Gln Val Lys Ser Lys 705 710 715 720 Asp Glu Phe Arg Gly Ser Leu Gly Thr Gln Ile Asn Gln Leu Leu Gly 725 730 735 Ile Ile Tyr Gly Leu Leu Ala Leu Ala Val Ile Ile Ala Val Leu Gly 740 745 750 Ile Val Asn Thr Leu Phe Leu Ser Ile Ser Glu Arg Thr Arg Glu Ile 755 760 765 Gly Ile Leu Arg Ala Thr Gly Val Gln Arg Gly Gln Ile Arg Arg Met 770 775 780 Ile Thr Leu Glu Ser Val Ile Leu Ser Ile His Gly Ala Ile His Gly 785 790 795 800 Leu Leu Leu Gly Thr Phe Ile Gly Trp Ala Ile Val Ser Cys Leu Arg 805 810 815 Thr Arg Gly Met Ala Pro Val Glu Phe Pro Trp Thr Gln Ile Gly Leu 820 825 830 Met Leu Ile Ser Ala Ile Ile Ile Gly Gly Ile Ala Ala Leu Ile Pro 835 840 845 Ala Asn Arg Ala Ser Arg Ile Ser Pro Leu Glu Ala Ile Asn 850 855 860 <210> 309 <211> 772 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(742) <223> RXA02570 <400> 309 ccattgttat gctcattgtg tttgtggtgg tcaagtcgct acccaagcgc accactaggg 60 cattggttcc gcagcgggtt ccggaggacg tcgcttaaac atg aat cct ttg aca 115 Met Asn Pro Leu Thr 1 5 tgg atc att ggc gca ttc agc atg tgg atc gtg gtg ctg ggc gtt aat 163 Trp Ile Ile Gly Ala Phe Ser Met Trp Ile Val Val Leu Gly Val Asn 10 15 20 aag ctt ggt tta agc atc gca gtg atc atc atc gcg cag gtc gtg gcg 211 Lys Leu Gly Leu Ser Ile Ala Val Ile Ile Ile Ala Gln Val Val Ala 25 30 35 atg att cgg gtg cgc aat gta tct gtg ttg gct tca aca gca ttg tta 259 Met Ile Arg Val Arg Asn Val Ser Val Leu Ala Ser Thr Ala Leu Leu 40 45 50 tcg gtt cct gca ttg gcc tcg atg gcg ctg att cac atg ccg tat tct 307 Ser Val Pro Ala Leu Ala Ser Met Ala Leu Ile His Met Pro Tyr Ser 55 60 65 tcc gac ggc tgg ttg att gct ctt acc ttg acg gct cgt ttt agt gcg 355 Ser Asp Gly Trp Leu Ile Ala Leu Thr Leu Thr Ala Arg Phe Ser Ala 70 75 80 85 ttg atg tct att ttc ctc ctt gca gca aca gcg att act att cct gag 403 Leu Met Ser Ile Phe Leu Leu Ala Ala Thr Ala Ile Thr Ile Pro Glu 90 95 100 ctg gtg aaa tcc cta tat cgt tgg ccc aag ctg gcg tat atc gtg ggt 451 Leu Val Lys Ser Leu Tyr Arg Trp Pro Lys Leu Ala Tyr Ile Val Gly 105 110 115 tct gca ttg cag atg att ccg cag ggt aaa cag acc ttg gcg ttg gtt 499 Ser Ala Leu Gln Met Ile Pro Gln Gly Lys Gln Thr Leu Ala Leu Val 120 125 130 cgt gat gcc aat gct ttg cgc ggg cgc agc gtt aaa ggt ccc gtg cgc 547 Arg Asp Ala Asn Ala Leu Arg Gly Arg Ser Val Lys Gly Pro Val Arg 135 140 145 gcg gtg aaa tat gtg ggt ttg ccc ctg att aca cat tta ctt agt gca 595 Ala Val Lys Tyr Val Gly Leu Pro Leu Ile Thr His Leu Leu Ser Ala 150 155 160 165 ggt gcc gcg cga gcg att ccc ttg gag gtc gca ggc ctg gac agg ccg 643 Gly Ala Ala Arg Ala Ile Pro Leu Glu Val Ala Gly Leu Asp Arg Pro 170 175 180 ggg ccg cgt acg gtg ttg gtt gag gtg gtg gag ggg cgc gtc gaa aag 691 Gly Pro Arg Thr Val Leu Val Glu Val Val Glu Gly Arg Val Glu Lys 185 190 195 cat tgt cgc tgg ttg ttg ccg ctt ttg gca gtc ggg atg gcg tgg tgg 739 His Cys Arg Trp Leu Leu Pro Leu Leu Ala Val Gly Met Ala Trp Trp 200 205 210 ctc taactcaaat cgtcggaccg tccggctccg 772 Leu <210> 310 <211> 214 <212> PRT <213> Corynebacterium glutamicum <400> 310 Met Asn Pro Leu Thr Trp Ile Ile Gly Ala Phe Ser Met Trp Ile Val 1 5 10 15 Val Leu Gly Val Asn Lys Leu Gly Leu Ser Ile Ala Val Ile Ile Ile 20 25 30 Ala Gln Val Val Ala Met Ile Arg Val Arg Asn Val Ser Val Leu Ala 35 40 45 Ser Thr Ala Leu Leu Ser Val Pro Ala Leu Ala Ser Met Ala Leu Ile 50 55 60 His Met Pro Tyr Ser Ser Asp Gly Trp Leu Ile Ala Leu Thr Leu Thr 65 70 75 80 Ala Arg Phe Ser Ala Leu Met Ser Ile Phe Leu Leu Ala Ala Thr Ala 85 90 95 Ile Thr Ile Pro Glu Leu Val Lys Ser Leu Tyr Arg Trp Pro Lys Leu 100 105 110 Ala Tyr Ile Val Gly Ser Ala Leu Gln Met Ile Pro Gln Gly Lys Gln 115 120 125 Thr Leu Ala Leu Val Arg Asp Ala Asn Ala Leu Arg Gly Arg Ser Val 130 135 140 Lys Gly Pro Val Arg Ala Val Lys Tyr Val Gly Leu Pro Leu Ile Thr 145 150 155 160 His Leu Leu Ser Ala Gly Ala Ala Arg Ala Ile Pro Leu Glu Val Ala 165 170 175 Gly Leu Asp Arg Pro Gly Pro Arg Thr Val Leu Val Glu Val Val Glu 180 185 190 Gly Arg Val Glu Lys His Cys Arg Trp Leu Leu Pro Leu Leu Ala Val 195 200 205 Gly Met Ala Trp Trp Leu 210 <210> 311 <211> 1960 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1930) <223> RXA02591 <400> 311 atgtgtccgt tgtctcacct aaagttttaa ctagttctgt atctgaaagc tacgctaggg 60 ggcgagaact ctgtcgaatg acacaaaatc tggagaagta atg act act gct gca 115 Met Thr Thr Ala Ala 1 5 atc agg ggc ctt cag ggc gag gcg ccg acc aag aat aag gaa ctg ctg 163 Ile Arg Gly Leu Gln Gly Glu Ala Pro Thr Lys Asn Lys Glu Leu Leu 10 15 20 aac tgg atc gca gac gcc gtc gag ctc ttc cag cct gag gct gtt gtg 211 Asn Trp Ile Ala Asp Ala Val Glu Leu Phe Gln Pro Glu Ala Val Val 25 30 35 ttc gtt gat gga tcc cag gct gag tgg gat cgc atg gcg gag gat ctt 259 Phe Val Asp Gly Ser Gln Ala Glu Trp Asp Arg Met Ala Glu Asp Leu 40 45 50 gtt gaa gcc ggt acc ctc atc aag ctc aac gag gaa aag cgt ccg aac 307 Val Glu Ala Gly Thr Leu Ile Lys Leu Asn Glu Glu Lys Arg Pro Asn 55 60 65 agc tac cta gct cgt tcc aac cca tct gac gtt gcg cgc gtt gag tcc 355 Ser Tyr Leu Ala Arg Ser Asn Pro Ser Asp Val Ala Arg Val Glu Ser 70 75 80 85 cgc acc ttc atc tgc tcc gag aag gaa gaa gat gct ggc cca acc aac 403 Arg Thr Phe Ile Cys Ser Glu Lys Glu Glu Asp Ala Gly Pro Thr Asn 90 95 100 aac tgg gct cca cca cag gca atg aag gac gaa atg tcc aag cat tac 451 Asn Trp Ala Pro Pro Gln Ala Met Lys Asp Glu Met Ser Lys His Tyr 105 110 115 gct ggt tcc atg aag ggg cgc acc atg tac gtc gtg cct ttc tgc atg 499 Ala Gly Ser Met Lys Gly Arg Thr Met Tyr Val Val Pro Phe Cys Met 120 125 130 ggt cca atc agc gat ccg gac cct aag ctt ggt gtg cag ctc act gac 547 Gly Pro Ile Ser Asp Pro Asp Pro Lys Leu Gly Val Gln Leu Thr Asp 135 140 145 tcc gag tac gtt gtc atg tcc atg cgc atc atg acc cgc atg ggt att 595 Ser Glu Tyr Val Val Met Ser Met Arg Ile Met Thr Arg Met Gly Ile 150 155 160 165 gaa gcg ctg gac aag atc ggc gcg aac ggc agc ttc gtc agg tgc ctc 643 Glu Ala Leu Asp Lys Ile Gly Ala Asn Gly Ser Phe Val Arg Cys Leu 170 175 180 cac tcc gtt ggt gct cct ttg gag cca ggc cag gaa gac gtt gca tgg 691 His Ser Val Gly Ala Pro Leu Glu Pro Gly Gln Glu Asp Val Ala Trp 185 190 195 cct tgc aac gac acc aag tac atc acc cag ttc cca gag acc aag gaa 739 Pro Cys Asn Asp Thr Lys Tyr Ile Thr Gln Phe Pro Glu Thr Lys Glu 200 205 210 att tgg tcc tac ggt tcc ggc tac ggc gga aac gca atc ctg gca aag 787 Ile Trp Ser Tyr Gly Ser Gly Tyr Gly Gly Asn Ala Ile Leu Ala Lys 215 220 225 aag tgc tac gca ctg cgt atc gca tct gtc atg gct cgc gaa gaa gga 835 Lys Cys Tyr Ala Leu Arg Ile Ala Ser Val Met Ala Arg Glu Glu Gly 230 235 240 245 tgg atg gct gag cac atg ctc atc ctg aag ctg atc aac cca gag ggc 883 Trp Met Ala Glu His Met Leu Ile Leu Lys Leu Ile Asn Pro Glu Gly 250 255 260 aag gcg tac cac atc gca gca gca ttc cca tct gct tgt ggc aag acc 931 Lys Ala Tyr His Ile Ala Ala Ala Phe Pro Ser Ala Cys Gly Lys Thr 265 270 275 aac ctc gcc atg atc act cca acc atc cca ggc tgg acc gct cag gtt 979 Asn Leu Ala Met Ile Thr Pro Thr Ile Pro Gly Trp Thr Ala Gln Val 280 285 290 gtt ggc gac gac atc gct tgg ctg aag ctg cgc gag gac ggc ctc tac 1027 Val Gly Asp Asp Ile Ala Trp Leu Lys Leu Arg Glu Asp Gly Leu Tyr 295 300 305 gca gtt aac cca gaa aat ggt ttc ttc ggt gtt gct cca ggc acc aac 1075 Ala Val Asn Pro Glu Asn Gly Phe Phe Gly Val Ala Pro Gly Thr Asn 310 315 320 325 tac gca tcc aac cca atc gcg atg aag acc atg gaa cca ggc aac acc 1123 Tyr Ala Ser Asn Pro Ile Ala Met Lys Thr Met Glu Pro Gly Asn Thr 330 335 340 ctg ttc acc aac gtg gca ctc acc gac gac ggc gac atc tgg tgg gaa 1171 Leu Phe Thr Asn Val Ala Leu Thr Asp Asp Gly Asp Ile Trp Trp Glu 345 350 355 ggc atg gac ggc gac gcc cca gct cac ctc att gac tgg atg ggc aac 1219 Gly Met Asp Gly Asp Ala Pro Ala His Leu Ile Asp Trp Met Gly Asn 360 365 370 gac tgg acc cca gag tcc gac gaa aac gct gct cac cct aac tcc cgt 1267 Asp Trp Thr Pro Glu Ser Asp Glu Asn Ala Ala His Pro Asn Ser Arg 375 380 385 tac tgc gta gca atc gac cag tcc cca gca gca gca cct gag ttc aac 1315 Tyr Cys Val Ala Ile Asp Gln Ser Pro Ala Ala Ala Pro Glu Phe Asn 390 395 400 405 gac tgg gaa ggc gtc aag atc gac gca atc ctc ttc ggt gga cgt cgc 1363 Asp Trp Glu Gly Val Lys Ile Asp Ala Ile Leu Phe Gly Gly Arg Arg 410 415 420 gca gac acc gtc cca ctg gtt acc cag acc tac gac tgg gag cac ggc 1411 Ala Asp Thr Val Pro Leu Val Thr Gln Thr Tyr Asp Trp Glu His Gly 425 430 435 acc atg gtt ggt gca ctg ctc gca tcc ggt cag acc gca gct tcc gca 1459 Thr Met Val Gly Ala Leu Leu Ala Ser Gly Gln Thr Ala Ala Ser Ala 440 445 450 gaa gca aag gtc ggc aca ctc cgc cac gac cca atg gca atg ctc cca 1507 Glu Ala Lys Val Gly Thr Leu Arg His Asp Pro Met Ala Met Leu Pro 455 460 465 ttc att ggc tac aac gct ggt gaa tac ctg cag aac tgg att gac atg 1555 Phe Ile Gly Tyr Asn Ala Gly Glu Tyr Leu Gln Asn Trp Ile Asp Met 470 475 480 485 ggt aac aag ggt ggc gac aag atg cca tcc atc ttc ctg gtc aac tgg 1603 Gly Asn Lys Gly Gly Asp Lys Met Pro Ser Ile Phe Leu Val Asn Trp 490 495 500 ttc cgc cgt ggc gaa gat gga cgc ttc ctg tgg cct ggc ttc ggc gac 1651 Phe Arg Arg Gly Glu Asp Gly Arg Phe Leu Trp Pro Gly Phe Gly Asp 505 510 515 aac tct cgc gtt ctg aag tgg gtc atc gac cgc atc gaa ggc cac gtt 1699 Asn Ser Arg Val Leu Lys Trp Val Ile Asp Arg Ile Glu Gly His Val 520 525 530 ggc gca gac gag acc gtt gtt gga cac acc gct aag gcc gaa gac ctc 1747 Gly Ala Asp Glu Thr Val Val Gly His Thr Ala Lys Ala Glu Asp Leu 535 540 545 gac ctc gac ggc ctc gac acc cca att gag gat gtc aag gaa gca ctg 1795 Asp Leu Asp Gly Leu Asp Thr Pro Ile Glu Asp Val Lys Glu Ala Leu 550 555 560 565 acc gct cct gca gag cag tgg gca aac gac gtt gaa gac aac gcc gag 1843 Thr Ala Pro Ala Glu Gln Trp Ala Asn Asp Val Glu Asp Asn Ala Glu 570 575 580 tac ctc act ttc ctc gga cca cgt gtt cct gca gag gtt cac agc cag 1891 Tyr Leu Thr Phe Leu Gly Pro Arg Val Pro Ala Glu Val His Ser Gln 585 590 595 ttc gat gct ctg aag gcc cgc att tca gca gct cac gct taaagttcac 1940 Phe Asp Ala Leu Lys Ala Arg Ile Ser Ala Ala His Ala 600 605 610 gcttaagaac tgctaaataa 1960 <210> 312 <211> 610 <212> PRT <213> Corynebacterium glutamicum <400> 312 Met Thr Thr Ala Ala Ile Arg Gly Leu Gln Gly Glu Ala Pro Thr Lys 1 5 10 15 Asn Lys Glu Leu Leu Asn Trp Ile Ala Asp Ala Val Glu Leu Phe Gln 20 25 30 Pro Glu Ala Val Val Phe Val Asp Gly Ser Gln Ala Glu Trp Asp Arg 35 40 45 Met Ala Glu Asp Leu Val Glu Ala Gly Thr Leu Ile Lys Leu Asn Glu 50 55 60 Glu Lys Arg Pro Asn Ser Tyr Leu Ala Arg Ser Asn Pro Ser Asp Val 65 70 75 80 Ala Arg Val Glu Ser Arg Thr Phe Ile Cys Ser Glu Lys Glu Glu Asp 85 90 95 Ala Gly Pro Thr Asn Asn Trp Ala Pro Pro Gln Ala Met Lys Asp Glu 100 105 110 Met Ser Lys His Tyr Ala Gly Ser Met Lys Gly Arg Thr Met Tyr Val 115 120 125 Val Pro Phe Cys Met Gly Pro Ile Ser Asp Pro Asp Pro Lys Leu Gly 130 135 140 Val Gln Leu Thr Asp Ser Glu Tyr Val Val Met Ser Met Arg Ile Met 145 150 155 160 Thr Arg Met Gly Ile Glu Ala Leu Asp Lys Ile Gly Ala Asn Gly Ser 165 170 175 Phe Val Arg Cys Leu His Ser Val Gly Ala Pro Leu Glu Pro Gly Gln 180 185 190 Glu Asp Val Ala Trp Pro Cys Asn Asp Thr Lys Tyr Ile Thr Gln Phe 195 200 205 Pro Glu Thr Lys Glu Ile Trp Ser Tyr Gly Ser Gly Tyr Gly Gly Asn 210 215 220 Ala Ile Leu Ala Lys Lys Cys Tyr Ala Leu Arg Ile Ala Ser Val Met 225 230 235 240 Ala Arg Glu Glu Gly Trp Met Ala Glu His Met Leu Ile Leu Lys Leu 245 250 255 Ile Asn Pro Glu Gly Lys Ala Tyr His Ile Ala Ala Ala Phe Pro Ser 260 265 270 Ala Cys Gly Lys Thr Asn Leu Ala Met Ile Thr Pro Thr Ile Pro Gly 275 280 285 Trp Thr Ala Gln Val Val Gly Asp Asp Ile Ala Trp Leu Lys Leu Arg 290 295 300 Glu Asp Gly Leu Tyr Ala Val Asn Pro Glu Asn Gly Phe Phe Gly Val 305 310 315 320 Ala Pro Gly Thr Asn Tyr Ala Ser Asn Pro Ile Ala Met Lys Thr Met 325 330 335 Glu Pro Gly Asn Thr Leu Phe Thr Asn Val Ala Leu Thr Asp Asp Gly 340 345 350 Asp Ile Trp Trp Glu Gly Met Asp Gly Asp Ala Pro Ala His Leu Ile 355 360 365 Asp Trp Met Gly Asn Asp Trp Thr Pro Glu Ser Asp Glu Asn Ala Ala 370 375 380 His Pro Asn Ser Arg Tyr Cys Val Ala Ile Asp Gln Ser Pro Ala Ala 385 390 395 400 Ala Pro Glu Phe Asn Asp Trp Glu Gly Val Lys Ile Asp Ala Ile Leu 405 410 415 Phe Gly Gly Arg Arg Ala Asp Thr Val Pro Leu Val Thr Gln Thr Tyr 420 425 430 Asp Trp Glu His Gly Thr Met Val Gly Ala Leu Leu Ala Ser Gly Gln 435 440 445 Thr Ala Ala Ser Ala Glu Ala Lys Val Gly Thr Leu Arg His Asp Pro 450 455 460 Met Ala Met Leu Pro Phe Ile Gly Tyr Asn Ala Gly Glu Tyr Leu Gln 465 470 475 480 Asn Trp Ile Asp Met Gly Asn Lys Gly Gly Asp Lys Met Pro Ser Ile 485 490 495 Phe Leu Val Asn Trp Phe Arg Arg Gly Glu Asp Gly Arg Phe Leu Trp 500 505 510 Pro Gly Phe Gly Asp Asn Ser Arg Val Leu Lys Trp Val Ile Asp Arg 515 520 525 Ile Glu Gly His Val Gly Ala Asp Glu Thr Val Val Gly His Thr Ala 530 535 540 Lys Ala Glu Asp Leu Asp Leu Asp Gly Leu Asp Thr Pro Ile Glu Asp 545 550 555 560 Val Lys Glu Ala Leu Thr Ala Pro Ala Glu Gln Trp Ala Asn Asp Val 565 570 575 Glu Asp Asn Ala Glu Tyr Leu Thr Phe Leu Gly Pro Arg Val Pro Ala 580 585 590 Glu Val His Ser Gln Phe Asp Ala Leu Lys Ala Arg Ile Ser Ala Ala 595 600 605 His Ala 610 <210> 313 <211> 2206 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2176) <223> RXA02604 <400> 313 tctgcatcgt gatggctgtg tacatcatgc cgatgttttg aatatttacc aatgaacatg 60 ctctgaccag catgtccatt aacgtttgag gccacatgcg gtg cta gca tgt ggc 115 Val Leu Ala Cys Gly 1 5 ctc atg acg ttt agc ccc cag cgt ccg gag ttt gag acc ggt aag cag 163 Leu Met Thr Phe Ser Pro Gln Arg Pro Glu Phe Glu Thr Gly Lys Gln 10 15 20 cca gat cca gaa act gaa cac gca ggt gac ttc ttt gaa gaa acc tca 211 Pro Asp Pro Glu Thr Glu His Ala Gly Asp Phe Phe Glu Glu Thr Ser 25 30 35 agc agt gct cct cgc gcc gca tct aac ggt tct tct ggt ccg aac tac 259 Ser Ser Ala Pro Arg Ala Ala Ser Asn Gly Ser Ser Gly Pro Asn Tyr 40 45 50 acc ctc att aca acg ttt cta gcg gcc ctt act gct ggc atc ttt gct 307 Thr Leu Ile Thr Thr Phe Leu Ala Ala Leu Thr Ala Gly Ile Phe Ala 55 60 65 ttc tgg gca ggc tgg acc cgc aaa tgg atc agc gac gac gga ctg atc 355 Phe Trp Ala Gly Trp Thr Arg Lys Trp Ile Ser Asp Asp Gly Leu Ile 70 75 80 85 gtc cta cgc acc gtc cga aac ctc ctg gct gga aac ggg cca gta ttc 403 Val Leu Arg Thr Val Arg Asn Leu Leu Ala Gly Asn Gly Pro Val Phe 90 95 100 aac gct ggc gaa cgc gtc gaa gcc aac aca tct act ctg tgg caa tac 451 Asn Ala Gly Glu Arg Val Glu Ala Asn Thr Ser Thr Leu Trp Gln Tyr 105 110 115 tgc atc tat ctg gtt gcc tta gta act gac tat cgc ctc gaa gat att 499 Cys Ile Tyr Leu Val Ala Leu Val Thr Asp Tyr Arg Leu Glu Asp Ile 120 125 130 gct ctg tgg ctt gcg ctg ctg ttc acc acc gca gcg tcc atc atc ggt 547 Ala Leu Trp Leu Ala Leu Leu Phe Thr Thr Ala Ala Ser Ile Ile Gly 135 140 145 gtc ctg ggt acc gcg cat ctc cac cgc aaa cgc att gcc gta ttg ctt 595 Val Leu Gly Thr Ala His Leu His Arg Lys Arg Ile Ala Val Leu Leu 150 155 160 165 cct gca ggc gtg atc ggc tac ttc agc ctt tcc ccg gcg cga gac ttt 643 Pro Ala Gly Val Ile Gly Tyr Phe Ser Leu Ser Pro Ala Arg Asp Phe 170 175 180 gcc act tcc gga ttg gag tgg ggc cta tct ttg atg tgg att tcc atc 691 Ala Thr Ser Gly Leu Glu Trp Gly Leu Ser Leu Met Trp Ile Ser Ile 185 190 195 caa tgg ctg ctg ctg gtg ttg tgg gcg act tcg ggc aag acc tcg ggc 739 Gln Trp Leu Leu Leu Val Leu Trp Ala Thr Ser Gly Lys Thr Ser Gly 200 205 210 aag aag gct tcg ggc gca aaa act tca aat cct atc gtt aat gcc ggt 787 Lys Lys Ala Ser Gly Ala Lys Thr Ser Asn Pro Ile Val Asn Ala Gly 215 220 225 gca ata acc tat gct ttg gcc ttt tgg tca ggc ttg agc tgg ctg gtt 835 Ala Ile Thr Tyr Ala Leu Ala Phe Trp Ser Gly Leu Ser Trp Leu Val 230 235 240 245 cgc cca gaa ctg gcg atg tat ggc ggt ttg act gga gtg ttg ctg ctg 883 Arg Pro Glu Leu Ala Met Tyr Gly Gly Leu Thr Gly Val Leu Leu Leu 250 255 260 ctt act gcg cca cga tgg cgg gta gtt ttg ggg atc ctg gtg gcg gct 931 Leu Thr Ala Pro Arg Trp Arg Val Val Leu Gly Ile Leu Val Ala Ala 265 270 275 ttg cct ctt cca gct gcg tac caa atc ttc cgc atg ggt tat tac ggg 979 Leu Pro Leu Pro Ala Ala Tyr Gln Ile Phe Arg Met Gly Tyr Tyr Gly 280 285 290 ctg atg gtg ccg cac acg gct gta gcg aaa tca gcc tca gat gcg gtg 1027 Leu Met Val Pro His Thr Ala Val Ala Lys Ser Ala Ser Asp Ala Val 295 300 305 tgg ggg act ggt tgg gaa tat gtt gag gat ttc acg ggg cct tac aac 1075 Trp Gly Thr Gly Trp Glu Tyr Val Glu Asp Phe Thr Gly Pro Tyr Asn 310 315 320 325 ctg tgg ctc ggt ttg gcc ttg ctg ttg gcc gca ggc gcg ttg aca gtg 1123 Leu Trp Leu Gly Leu Ala Leu Leu Leu Ala Ala Gly Ala Leu Thr Val 330 335 340 tgg aaa act gac aag cac tta gcg ata ccg aag ggg cgg ctg ggg ctg 1171 Trp Lys Thr Asp Lys His Leu Ala Ile Pro Lys Gly Arg Leu Gly Leu 345 350 355 cgc act ccg ggt atg gct ata gcg ttg ctg gtt atc tgt gcg ctc gtc 1219 Arg Thr Pro Gly Met Ala Ile Ala Leu Leu Val Ile Cys Ala Leu Val 360 365 370 cac ttc ctt tac gtt atc cgt gtt ggt ggc gac ttc atg cat gga cgc 1267 His Phe Leu Tyr Val Ile Arg Val Gly Gly Asp Phe Met His Gly Arg 375 380 385 atg ctg ctc ctt cca ctt ttt gcc att ctg ctg cct gtt tct gtc att 1315 Met Leu Leu Leu Pro Leu Phe Ala Ile Leu Leu Pro Val Ser Val Ile 390 395 400 405 ccg gtc aat gtt gtt gat cga ggt tgg cag gat ttg gtt gcg ctg gtt 1363 Pro Val Asn Val Val Asp Arg Gly Trp Gln Asp Leu Val Ala Leu Val 410 415 420 ctc gtt ttc tct acg tgg gtg tgg tcc act gtg gtt ttt gtg cag ggg 1411 Leu Val Phe Ser Thr Trp Val Trp Ser Thr Val Val Phe Val Gln Gly 425 430 435 cac caa tgg gaa aat acc ggc cag cat gtg gtt gat gag cgt gat ttt 1459 His Gln Trp Glu Asn Thr Gly Gln His Val Val Asp Glu Arg Asp Phe 440 445 450 tgg att gat ttc acc aac cga gat gaa gat cat cct ccg ctt tat gca 1507 Trp Ile Asp Phe Thr Asn Arg Asp Glu Asp His Pro Pro Leu Tyr Ala 455 460 465 gag gat ttc ctc act gtt gat tcc atg aat gat tac gca gag gtt atg 1555 Glu Asp Phe Leu Thr Val Asp Ser Met Asn Asp Tyr Ala Glu Val Met 470 475 480 485 cgc gat cag acg ttg gtt aat cca aca ggc cag caa ctc aat att ctg 1603 Arg Asp Gln Thr Leu Val Asn Pro Thr Gly Gln Gln Leu Asn Ile Leu 490 495 500 gcc agc agt gac ccg acc act tat tcg tgg atc acc aca cct cgc gtg 1651 Ala Ser Ser Asp Pro Thr Thr Tyr Ser Trp Ile Thr Thr Pro Arg Val 505 510 515 gag ggg gtt gaa gcc ggt gat ttg gct aac ctc tcg cca act gtt ttc 1699 Glu Gly Val Glu Ala Gly Asp Leu Ala Asn Leu Ser Pro Thr Val Phe 520 525 530 cat gtg aac ctc ggc atg acc tcc atg aac gca ccg ctc aac gtg cgt 1747 His Val Asn Leu Gly Met Thr Ser Met Asn Ala Pro Leu Asn Val Arg 535 540 545 gtg aca gac ctg att ggt ttg gca acg cca ctg gca gcc cgc cag cca 1795 Val Thr Asp Leu Ile Gly Leu Ala Thr Pro Leu Ala Ala Arg Gln Pro 550 555 560 565 cgc att gaa ggt ggt cga atc ggc cac gat aaa ttg atg gac ttg gaa 1843 Arg Ile Glu Gly Gly Arg Ile Gly His Asp Lys Leu Met Asp Leu Glu 570 575 580 tgg cag gtc gcg gaa tcc gcc act ccg ctg gcg tac aca ccg ggt tgg 1891 Trp Gln Val Ala Glu Ser Ala Thr Pro Leu Ala Tyr Thr Pro Gly Trp 585 590 595 ttg gat act caa aag act tat gag gcc cgc cag gcg cta cgc cac cca 1939 Leu Asp Thr Gln Lys Thr Tyr Glu Ala Arg Gln Ala Leu Arg His Pro 600 605 610 gaa ttg gtt cac ctt ttc cag act tac cgt gag cca atg tcc tac cac 1987 Glu Leu Val His Leu Phe Gln Thr Tyr Arg Glu Pro Met Ser Tyr His 615 620 625 cgg ttt gtg gac aat att aaa tac gca ctc act acc gga aga aca ctg 2035 Arg Phe Val Asp Asn Ile Lys Tyr Ala Leu Thr Thr Gly Arg Thr Leu 630 635 640 645 gaa att tca gat aat cct gaa gat ctt ttg aaa gaa ttt aac ccg acc 2083 Glu Ile Ser Asp Asn Pro Glu Asp Leu Leu Lys Glu Phe Asn Pro Thr 650 655 660 cct gca gag att cag gac ggg tta gaa act att gct tgg cct ggg gaa 2131 Pro Ala Glu Ile Gln Asp Gly Leu Glu Thr Ile Ala Trp Pro Gly Glu 665 670 675 att aaa ctt gat gaa cct cgc gga gaa cct tta tat agc tct cag 2176 Ile Lys Leu Asp Glu Pro Arg Gly Glu Pro Leu Tyr Ser Ser Gln 680 685 690 taaacactta ttcgcaaatc attgggctgt 2206 <210> 314 <211> 692 <212> PRT <213> Corynebacterium glutamicum <400> 314 Val Leu Ala Cys Gly Leu Met Thr Phe Ser Pro Gln Arg Pro Glu Phe 1 5 10 15 Glu Thr Gly Lys Gln Pro Asp Pro Glu Thr Glu His Ala Gly Asp Phe 20 25 30 Phe Glu Glu Thr Ser Ser Ser Ala Pro Arg Ala Ala Ser Asn Gly Ser 35 40 45 Ser Gly Pro Asn Tyr Thr Leu Ile Thr Thr Phe Leu Ala Ala Leu Thr 50 55 60 Ala Gly Ile Phe Ala Phe Trp Ala Gly Trp Thr Arg Lys Trp Ile Ser 65 70 75 80 Asp Asp Gly Leu Ile Val Leu Arg Thr Val Arg Asn Leu Leu Ala Gly 85 90 95 Asn Gly Pro Val Phe Asn Ala Gly Glu Arg Val Glu Ala Asn Thr Ser 100 105 110 Thr Leu Trp Gln Tyr Cys Ile Tyr Leu Val Ala Leu Val Thr Asp Tyr 115 120 125 Arg Leu Glu Asp Ile Ala Leu Trp Leu Ala Leu Leu Phe Thr Thr Ala 130 135 140 Ala Ser Ile Ile Gly Val Leu Gly Thr Ala His Leu His Arg Lys Arg 145 150 155 160 Ile Ala Val Leu Leu Pro Ala Gly Val Ile Gly Tyr Phe Ser Leu Ser 165 170 175 Pro Ala Arg Asp Phe Ala Thr Ser Gly Leu Glu Trp Gly Leu Ser Leu 180 185 190 Met Trp Ile Ser Ile Gln Trp Leu Leu Leu Val Leu Trp Ala Thr Ser 195 200 205 Gly Lys Thr Ser Gly Lys Lys Ala Ser Gly Ala Lys Thr Ser Asn Pro 210 215 220 Ile Val Asn Ala Gly Ala Ile Thr Tyr Ala Leu Ala Phe Trp Ser Gly 225 230 235 240 Leu Ser Trp Leu Val Arg Pro Glu Leu Ala Met Tyr Gly Gly Leu Thr 245 250 255 Gly Val Leu Leu Leu Leu Thr Ala Pro Arg Trp Arg Val Val Leu Gly 260 265 270 Ile Leu Val Ala Ala Leu Pro Leu Pro Ala Ala Tyr Gln Ile Phe Arg 275 280 285 Met Gly Tyr Tyr Gly Leu Met Val Pro His Thr Ala Val Ala Lys Ser 290 295 300 Ala Ser Asp Ala Val Trp Gly Thr Gly Trp Glu Tyr Val Glu Asp Phe 305 310 315 320 Thr Gly Pro Tyr Asn Leu Trp Leu Gly Leu Ala Leu Leu Leu Ala Ala 325 330 335 Gly Ala Leu Thr Val Trp Lys Thr Asp Lys His Leu Ala Ile Pro Lys 340 345 350 Gly Arg Leu Gly Leu Arg Thr Pro Gly Met Ala Ile Ala Leu Leu Val 355 360 365 Ile Cys Ala Leu Val His Phe Leu Tyr Val Ile Arg Val Gly Gly Asp 370 375 380 Phe Met His Gly Arg Met Leu Leu Leu Pro Leu Phe Ala Ile Leu Leu 385 390 395 400 Pro Val Ser Val Ile Pro Val Asn Val Val Asp Arg Gly Trp Gln Asp 405 410 415 Leu Val Ala Leu Val Leu Val Phe Ser Thr Trp Val Trp Ser Thr Val 420 425 430 Val Phe Val Gln Gly His Gln Trp Glu Asn Thr Gly Gln His Val Val 435 440 445 Asp Glu Arg Asp Phe Trp Ile Asp Phe Thr Asn Arg Asp Glu Asp His 450 455 460 Pro Pro Leu Tyr Ala Glu Asp Phe Leu Thr Val Asp Ser Met Asn Asp 465 470 475 480 Tyr Ala Glu Val Met Arg Asp Gln Thr Leu Val Asn Pro Thr Gly Gln 485 490 495 Gln Leu Asn Ile Leu Ala Ser Ser Asp Pro Thr Thr Tyr Ser Trp Ile 500 505 510 Thr Thr Pro Arg Val Glu Gly Val Glu Ala Gly Asp Leu Ala Asn Leu 515 520 525 Ser Pro Thr Val Phe His Val Asn Leu Gly Met Thr Ser Met Asn Ala 530 535 540 Pro Leu Asn Val Arg Val Thr Asp Leu Ile Gly Leu Ala Thr Pro Leu 545 550 555 560 Ala Ala Arg Gln Pro Arg Ile Glu Gly Gly Arg Ile Gly His Asp Lys 565 570 575 Leu Met Asp Leu Glu Trp Gln Val Ala Glu Ser Ala Thr Pro Leu Ala 580 585 590 Tyr Thr Pro Gly Trp Leu Asp Thr Gln Lys Thr Tyr Glu Ala Arg Gln 595 600 605 Ala Leu Arg His Pro Glu Leu Val His Leu Phe Gln Thr Tyr Arg Glu 610 615 620 Pro Met Ser Tyr His Arg Phe Val Asp Asn Ile Lys Tyr Ala Leu Thr 625 630 635 640 Thr Gly Arg Thr Leu Glu Ile Ser Asp Asn Pro Glu Asp Leu Leu Lys 645 650 655 Glu Phe Asn Pro Thr Pro Ala Glu Ile Gln Asp Gly Leu Glu Thr Ile 660 665 670 Ala Trp Pro Gly Glu Ile Lys Leu Asp Glu Pro Arg Gly Glu Pro Leu 675 680 685 Tyr Ser Ser Gln 690 <210> 315 <211> 1048 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1018) <223> RXA02678 <400> 315 ctgtgggcgc gcgaacaggg cgtcgacatg ctcgccacca attatccgga ccgtgcggcg 60 gagcttttga acgcacatcc caagcccgcc atgtacgcta atg cgc atg gca aag 115 Met Arg Met Ala Lys 1 5 aag act aag aag aat gaa cag ctg ccg gag ggc atg agc cgt cgt cag 163 Lys Thr Lys Lys Asn Glu Gln Leu Pro Glu Gly Met Ser Arg Arg Gln 10 15 20 gca aaa ctt gca gcc cgc gcg gct gaa cgt gca gca ctt gag cgt gaa 211 Ala Lys Leu Ala Ala Arg Ala Ala Glu Arg Ala Ala Leu Glu Arg Glu 25 30 35 cct cgc cca ttc gag ggc ctg gca atg gag tca cag ctc gtt gca ctg 259 Pro Arg Pro Phe Glu Gly Leu Ala Met Glu Ser Gln Leu Val Ala Leu 40 45 50 cag gaa ttc att cca tct gca acc gca ccc atc acc gtt gca ggc acc 307 Gln Glu Phe Ile Pro Ser Ala Thr Ala Pro Ile Thr Val Ala Gly Thr 55 60 65 gat cgc aag atc acc ctc tgt acc gtg ctt cca ggc gca gct gcg gca 355 Asp Arg Lys Ile Thr Leu Cys Thr Val Leu Pro Gly Ala Ala Ala Ala 70 75 80 85 ctt gtc cgc gaa gaa gca ttc ggc ggc gaa gcg ttt gtt gca atg cag 403 Leu Val Arg Glu Glu Ala Phe Gly Gly Glu Ala Phe Val Ala Met Gln 90 95 100 cag gcc atc cgc tcc aac aac cca agc aag gac ctc gcg ttc gcg ctg 451 Gln Ala Ile Arg Ser Asn Asn Pro Ser Lys Asp Leu Ala Phe Ala Leu 105 110 115 aac tgg gtc atc aac gca aaa gcc ggc gag tca ctg gcc acc gcc aca 499 Asn Trp Val Ile Asn Ala Lys Ala Gly Glu Ser Leu Ala Thr Ala Thr 120 125 130 gcg gac ggc acc cag cca gag cta aag agc ttg ctt aac gac gcc gac 547 Ala Asp Gly Thr Gln Pro Glu Leu Lys Ser Leu Leu Asn Asp Ala Asp 135 140 145 acc ctc gaa atc acc act cac cag gac ttc aac tgg tgg ctg gcg gaa 595 Thr Leu Glu Ile Thr Thr His Gln Asp Phe Asn Trp Trp Leu Ala Glu 150 155 160 165 aac gac aac ctc tcc cca gaa gtt gcg cag cac atg cag gca gcc aat 643 Asn Asp Asn Leu Ser Pro Glu Val Ala Gln His Met Gln Ala Ala Asn 170 175 180 gac tcc atc ctg cct tca cac gaa gtc gaa gca gac gtc cca ggc gct 691 Asp Ser Ile Leu Pro Ser His Glu Val Glu Ala Asp Val Pro Gly Ala 185 190 195 gtt tgg tgg gtc aac cca ggc gga aaa gcg cac atc cgt tgg gtc cgc 739 Val Trp Trp Val Asn Pro Gly Gly Lys Ala His Ile Arg Trp Val Arg 200 205 210 acc gaa aac gaa acc gca ctg ttc aac gct ttg gca cgc atc gca gca 787 Thr Glu Asn Glu Thr Ala Leu Phe Asn Ala Leu Ala Arg Ile Ala Ala 215 220 225 cgt ggc gag ctg aat ctc ggc gaa gaa act aag ttc gct ggt gct ttc 835 Arg Gly Glu Leu Asn Leu Gly Glu Glu Thr Lys Phe Ala Gly Ala Phe 230 235 240 245 cgc acc cac ggc atc gtc gtc cca gtg tgg gat ctc gat cct gag cgt 883 Arg Thr His Gly Ile Val Val Pro Val Trp Asp Leu Asp Pro Glu Arg 250 255 260 cca tcc acc gat tac gcc gat gtt ttg gtt gca ctc aac gag aag atc 931 Pro Ser Thr Asp Tyr Ala Asp Val Leu Val Ala Leu Asn Glu Lys Ile 265 270 275 gtc gct gaa ctg gat aac gat gca cag ctc aac gcc gac gag cgc cgt 979 Val Ala Glu Leu Asp Asn Asp Ala Gln Leu Asn Ala Asp Glu Arg Arg 280 285 290 cag ctg gag aac atc aag tcc cgc cag gtg acc atc cgc taaaatctct 1028 Gln Leu Glu Asn Ile Lys Ser Arg Gln Val Thr Ile Arg 295 300 305 taaaaacact tcaagcgcgt 1048 <210> 316 <211> 306 <212> PRT <213> Corynebacterium glutamicum <400> 316 Met Arg Met Ala Lys Lys Thr Lys Lys Asn Glu Gln Leu Pro Glu Gly 1 5 10 15 Met Ser Arg Arg Gln Ala Lys Leu Ala Ala Arg Ala Ala Glu Arg Ala 20 25 30 Ala Leu Glu Arg Glu Pro Arg Pro Phe Glu Gly Leu Ala Met Glu Ser 35 40 45 Gln Leu Val Ala Leu Gln Glu Phe Ile Pro Ser Ala Thr Ala Pro Ile 50 55 60 Thr Val Ala Gly Thr Asp Arg Lys Ile Thr Leu Cys Thr Val Leu Pro 65 70 75 80 Gly Ala Ala Ala Ala Leu Val Arg Glu Glu Ala Phe Gly Gly Glu Ala 85 90 95 Phe Val Ala Met Gln Gln Ala Ile Arg Ser Asn Asn Pro Ser Lys Asp 100 105 110 Leu Ala Phe Ala Leu Asn Trp Val Ile Asn Ala Lys Ala Gly Glu Ser 115 120 125 Leu Ala Thr Ala Thr Ala Asp Gly Thr Gln Pro Glu Leu Lys Ser Leu 130 135 140 Leu Asn Asp Ala Asp Thr Leu Glu Ile Thr Thr His Gln Asp Phe Asn 145 150 155 160 Trp Trp Leu Ala Glu Asn Asp Asn Leu Ser Pro Glu Val Ala Gln His 165 170 175 Met Gln Ala Ala Asn Asp Ser Ile Leu Pro Ser His Glu Val Glu Ala 180 185 190 Asp Val Pro Gly Ala Val Trp Trp Val Asn Pro Gly Gly Lys Ala His 195 200 205 Ile Arg Trp Val Arg Thr Glu Asn Glu Thr Ala Leu Phe Asn Ala Leu 210 215 220 Ala Arg Ile Ala Ala Arg Gly Glu Leu Asn Leu Gly Glu Glu Thr Lys 225 230 235 240 Phe Ala Gly Ala Phe Arg Thr His Gly Ile Val Val Pro Val Trp Asp 245 250 255 Leu Asp Pro Glu Arg Pro Ser Thr Asp Tyr Ala Asp Val Leu Val Ala 260 265 270 Leu Asn Glu Lys Ile Val Ala Glu Leu Asp Asn Asp Ala Gln Leu Asn 275 280 285 Ala Asp Glu Arg Arg Gln Leu Glu Asn Ile Lys Ser Arg Gln Val Thr 290 295 300 Ile Arg 305 <210> 317 <211> 1000 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(970) <223> RXA02683 <400> 317 gaagtgtcca gtcaactttt tggttaattg attatcttac ctagagactt ggatacttcc 60 ctccacggat tgctaacgat ccagttttat cgttggactc atg aaa aag atc cac 115 Met Lys Lys Ile His 1 5 atg att cca gcg gcc ctc ctc atc ggt tcc ctt gcg ctt gtt agc tgc 163 Met Ile Pro Ala Ala Leu Leu Ile Gly Ser Leu Ala Leu Val Ser Cys 10 15 20 gcg cct tca caa cct acc cag aac gcg cag acg gtt tct tct gtc atg 211 Ala Pro Ser Gln Pro Thr Gln Asn Ala Gln Thr Val Ser Ser Val Met 25 30 35 acg gaa act cct act tat acc tct tca tct agg tcg gtg gaa tct acc 259 Thr Glu Thr Pro Thr Tyr Thr Ser Ser Ser Arg Ser Val Glu Ser Thr 40 45 50 gcg ggg acg atc gct gcc tcg gag gaa gcc acg atg acg cta ctg gag 307 Ala Gly Thr Ile Ala Ala Ser Glu Glu Ala Thr Met Thr Leu Leu Glu 55 60 65 aat agt tcg ggg gat ccg gga tct gat tct ggg ggt gca cgc tat agc 355 Asn Ser Ser Gly Asp Pro Gly Ser Asp Ser Gly Gly Ala Arg Tyr Ser 70 75 80 85 ctc aat tcg ctc aaa gtt tct gag cag gcc gcg gct aac gcc gtc tta 403 Leu Asn Ser Leu Lys Val Ser Glu Gln Ala Ala Ala Asn Ala Val Leu 90 95 100 aag gcc gtg ctt aac gac gtc tcc tac caa gag ttc gca gac tcc tcc 451 Lys Ala Val Leu Asn Asp Val Ser Tyr Gln Glu Phe Ala Asp Ser Ser 105 110 115 tac tta gaa atc aca gga acg ccc tcc gcc gac gga aca tgg ggc atc 499 Tyr Leu Glu Ile Thr Gly Thr Pro Ser Ala Asp Gly Thr Trp Gly Ile 120 125 130 tca ttt ggc gga cct tcc gaa tcg gcc tcc gtg gaa ttc tcc gac ggc 547 Ser Phe Gly Gly Pro Ser Glu Ser Ala Ser Val Glu Phe Ser Asp Gly 135 140 145 agc atc agc ttc tcc cct gtt gac atg aca gtg ccc gca aca cga ttg 595 Ser Ile Ser Phe Ser Pro Val Asp Met Thr Val Pro Ala Thr Arg Leu 150 155 160 165 cct cag atg ggc gca ttt tat gaa acc ctg acc gaa gaa caa tta ggc 643 Pro Gln Met Gly Ala Phe Tyr Glu Thr Leu Thr Glu Glu Gln Leu Gly 170 175 180 atg ctg gag act ggc ctc gcg gtt tcc acc gtg gat tcg agc caa cag 691 Met Leu Glu Thr Gly Leu Ala Val Ser Thr Val Asp Ser Ser Gln Gln 185 190 195 gaa atg ctt ctg gac ttg gtc tcc aac tcg atc ggc ctg gca gat act 739 Glu Met Leu Leu Asp Leu Val Ser Asn Ser Ile Gly Leu Ala Asp Thr 200 205 210 gaa acc act gcg act gca att agt aaa atc cga gca acg ctt tcc gag 787 Glu Thr Thr Ala Thr Ala Ile Ser Lys Ile Arg Ala Thr Leu Ser Glu 215 220 225 acc tac ctg ttc gga acc ccc gac gga tta acc ttg gcg ctt agt ggc 835 Thr Tyr Leu Phe Gly Thr Pro Asp Gly Leu Thr Leu Ala Leu Ser Gly 230 235 240 245 cca cac gtt gat ttc gaa gtc tcc cac cag ggc agc acc gcg aaa att 883 Pro His Val Asp Phe Glu Val Ser His Gln Gly Ser Thr Ala Lys Ile 250 255 260 act tac cgc gat cca agc acc gac acc tta acc gcc gaa gat cgg gta 931 Thr Tyr Arg Asp Pro Ser Thr Asp Thr Leu Thr Ala Glu Asp Arg Val 265 270 275 gat acc gca agt gtg gct gct gct ccg ccg gag gtt gtt taggcgtttg 980 Asp Thr Ala Ser Val Ala Ala Ala Pro Pro Glu Val Val 280 285 290 ccgagaaatt ttcattgggc 1000 <210> 318 <211> 290 <212> PRT <213> Corynebacterium glutamicum <400> 318 Met Lys Lys Ile His Met Ile Pro Ala Ala Leu Leu Ile Gly Ser Leu 1 5 10 15 Ala Leu Val Ser Cys Ala Pro Ser Gln Pro Thr Gln Asn Ala Gln Thr 20 25 30 Val Ser Ser Val Met Thr Glu Thr Pro Thr Tyr Thr Ser Ser Ser Arg 35 40 45 Ser Val Glu Ser Thr Ala Gly Thr Ile Ala Ala Ser Glu Glu Ala Thr 50 55 60 Met Thr Leu Leu Glu Asn Ser Ser Gly Asp Pro Gly Ser Asp Ser Gly 65 70 75 80 Gly Ala Arg Tyr Ser Leu Asn Ser Leu Lys Val Ser Glu Gln Ala Ala 85 90 95 Ala Asn Ala Val Leu Lys Ala Val Leu Asn Asp Val Ser Tyr Gln Glu 100 105 110 Phe Ala Asp Ser Ser Tyr Leu Glu Ile Thr Gly Thr Pro Ser Ala Asp 115 120 125 Gly Thr Trp Gly Ile Ser Phe Gly Gly Pro Ser Glu Ser Ala Ser Val 130 135 140 Glu Phe Ser Asp Gly Ser Ile Ser Phe Ser Pro Val Asp Met Thr Val 145 150 155 160 Pro Ala Thr Arg Leu Pro Gln Met Gly Ala Phe Tyr Glu Thr Leu Thr 165 170 175 Glu Glu Gln Leu Gly Met Leu Glu Thr Gly Leu Ala Val Ser Thr Val 180 185 190 Asp Ser Ser Gln Gln Glu Met Leu Leu Asp Leu Val Ser Asn Ser Ile 195 200 205 Gly Leu Ala Asp Thr Glu Thr Thr Ala Thr Ala Ile Ser Lys Ile Arg 210 215 220 Ala Thr Leu Ser Glu Thr Tyr Leu Phe Gly Thr Pro Asp Gly Leu Thr 225 230 235 240 Leu Ala Leu Ser Gly Pro His Val Asp Phe Glu Val Ser His Gln Gly 245 250 255 Ser Thr Ala Lys Ile Thr Tyr Arg Asp Pro Ser Thr Asp Thr Leu Thr 260 265 270 Ala Glu Asp Arg Val Asp Thr Ala Ser Val Ala Ala Ala Pro Pro Glu 275 280 285 Val Val 290 <210> 319 <211> 868 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(838) <223> RXA02721 <400> 319 ccgtgatgat cgtcgtgacg atcgccgcga tgaccgcgga gacgacctgg atgtacccag 60 cttcctccag taattaagaa ggagaataga cttatccact atg gat agt ctt gac 115 Met Asp Ser Leu Asp 1 5 ccc cgc aac cgc ccc gtc cgc aag gtc ttc acg acc cgt gcc ggc ggg 163 Pro Arg Asn Arg Pro Val Arg Lys Val Phe Thr Thr Arg Ala Gly Gly 10 15 20 gtt tcg cag tcc ccg tat gct tcc ttc aac ctt ggt gat cac gtc ggc 211 Val Ser Gln Ser Pro Tyr Ala Ser Phe Asn Leu Gly Asp His Val Gly 25 30 35 gac gat cct caa gct gtg gca tcc aac cgc aat cgc ttg gct gac atc 259 Asp Asp Pro Gln Ala Val Ala Ser Asn Arg Asn Arg Leu Ala Asp Ile 40 45 50 atc ggt ttg tcc cca gac aag gtg gtg tac atg gag caa att cat tcc 307 Ile Gly Leu Ser Pro Asp Lys Val Val Tyr Met Glu Gln Ile His Ser 55 60 65 aat acc gtc aca gtc att gat gaa gcc cca gcg gat ggc cag gct gta 355 Asn Thr Val Thr Val Ile Asp Glu Ala Pro Ala Asp Gly Gln Ala Val 70 75 80 85 gag gcc acc gat gcg cta gtg acc acg caa cga ggg cta gcg ctg gcc 403 Glu Ala Thr Asp Ala Leu Val Thr Thr Gln Arg Gly Leu Ala Leu Ala 90 95 100 gtt ttg gtt gct gat tgc gtg cca gtg ctg ctg tca gac acc gac gct 451 Val Leu Val Ala Asp Cys Val Pro Val Leu Leu Ser Asp Thr Asp Ala 105 110 115 ggc gtg att gcg gca gtg cat gca ggc cgc atg gga gcc cgc aat ggc 499 Gly Val Ile Ala Ala Val His Ala Gly Arg Met Gly Ala Arg Asn Gly 120 125 130 atc gta gct aaa acc att gcg aag atg gag gag ctc ggc gcg aaa ccc 547 Ile Val Ala Lys Thr Ile Ala Lys Met Glu Glu Leu Gly Ala Lys Pro 135 140 145 agc cgc att cat gcg ctc atg ggt gca gcg gca tcg ggt gcg aac tac 595 Ser Arg Ile His Ala Leu Met Gly Ala Ala Ala Ser Gly Ala Asn Tyr 150 155 160 165 gag gtc cca gag gcc atg gcg cgc gat gtg gaa gcc aaa ctt cca ggt 643 Glu Val Pro Glu Ala Met Ala Arg Asp Val Glu Ala Lys Leu Pro Gly 170 175 180 tcc att gcg cgt acg aca aaa ggc acc aca gga ctg gac atc cgc gca 691 Ser Ile Ala Arg Thr Thr Lys Gly Thr Thr Gly Leu Asp Ile Arg Ala 185 190 195 ggg ctg ctg cgt caa atg ctc agc ctg ggt gtg caa atg att gat tct 739 Gly Leu Leu Arg Gln Met Leu Ser Leu Gly Val Gln Met Ile Asp Ser 200 205 210 gat cca cgc tgc acc atc gaa gac gaa gat ctg ttt tct tac cgc cgc 787 Asp Pro Arg Cys Thr Ile Glu Asp Glu Asp Leu Phe Ser Tyr Arg Arg 215 220 225 gaa ggc acg aca ggc cgc cag gcc ggc gtg gtg tgg ctg cca aag gag 835 Glu Gly Thr Thr Gly Arg Gln Ala Gly Val Val Trp Leu Pro Lys Glu 230 235 240 245 gca taaattggag cgccgcgaag agctgcaggt 868 Ala <210> 320 <211> 246 <212> PRT <213> Corynebacterium glutamicum <400> 320 Met Asp Ser Leu Asp Pro Arg Asn Arg Pro Val Arg Lys Val Phe Thr 1 5 10 15 Thr Arg Ala Gly Gly Val Ser Gln Ser Pro Tyr Ala Ser Phe Asn Leu 20 25 30 Gly Asp His Val Gly Asp Asp Pro Gln Ala Val Ala Ser Asn Arg Asn 35 40 45 Arg Leu Ala Asp Ile Ile Gly Leu Ser Pro Asp Lys Val Val Tyr Met 50 55 60 Glu Gln Ile His Ser Asn Thr Val Thr Val Ile Asp Glu Ala Pro Ala 65 70 75 80 Asp Gly Gln Ala Val Glu Ala Thr Asp Ala Leu Val Thr Thr Gln Arg 85 90 95 Gly Leu Ala Leu Ala Val Leu Val Ala Asp Cys Val Pro Val Leu Leu 100 105 110 Ser Asp Thr Asp Ala Gly Val Ile Ala Ala Val His Ala Gly Arg Met 115 120 125 Gly Ala Arg Asn Gly Ile Val Ala Lys Thr Ile Ala Lys Met Glu Glu 130 135 140 Leu Gly Ala Lys Pro Ser Arg Ile His Ala Leu Met Gly Ala Ala Ala 145 150 155 160 Ser Gly Ala Asn Tyr Glu Val Pro Glu Ala Met Ala Arg Asp Val Glu 165 170 175 Ala Lys Leu Pro Gly Ser Ile Ala Arg Thr Thr Lys Gly Thr Thr Gly 180 185 190 Leu Asp Ile Arg Ala Gly Leu Leu Arg Gln Met Leu Ser Leu Gly Val 195 200 205 Gln Met Ile Asp Ser Asp Pro Arg Cys Thr Ile Glu Asp Glu Asp Leu 210 215 220 Phe Ser Tyr Arg Arg Glu Gly Thr Thr Gly Arg Gln Ala Gly Val Val 225 230 235 240 Trp Leu Pro Lys Glu Ala 245 <210> 321 <211> 757 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(727) <223> RXA02725 <400> 321 gagttgtttt gttgagaaag cccgctgcac atcggtgtgg cgggttttct catgcccaga 60 tattgacctt gtcactgtgt caaggcattg aataagtgcc atg aac ata agt gcc 115 Met Asn Ile Ser Ala 1 5 atg gac aac ttc gaa cat tca aat gca tct atc cgt tta caa gca gcg 163 Met Asp Asn Phe Glu His Ser Asn Ala Ser Ile Arg Leu Gln Ala Ala 10 15 20 ttg gcc gca gga act gct gag gac acc act gcg atc gat att ctt ttg 211 Leu Ala Ala Gly Thr Ala Glu Asp Thr Thr Ala Ile Asp Ile Leu Leu 25 30 35 tac cgc agt ggg gta gaa gaa gac ttc ttt gtg cgc gac atg atc acg 259 Tyr Arg Ser Gly Val Glu Glu Asp Phe Phe Val Arg Asp Met Ile Thr 40 45 50 tgg gcg ctc acc cgc atg cca gtt gat gac gtg ttt acc tca ctg gtc 307 Trp Ala Leu Thr Arg Met Pro Val Asp Asp Val Phe Thr Ser Leu Val 55 60 65 gct gat ttg gat tct gag gta cct gat cga cca ttc ggt gca agt caa 355 Ala Asp Leu Asp Ser Glu Val Pro Asp Arg Pro Phe Gly Ala Ser Gln 70 75 80 85 gca ctc cac aca ctc tcc aag tta agg gtc gcg cag tcg tgg cag gaa 403 Ala Leu His Thr Leu Ser Lys Leu Arg Val Ala Gln Ser Trp Gln Glu 90 95 100 ttg caa gca cgg cct tgg ctt ttg cac cgg gag gac acc gcc caa act 451 Leu Gln Ala Arg Pro Trp Leu Leu His Arg Glu Asp Thr Ala Gln Thr 105 110 115 gcg tgg cga acc ttt gtg gga ctg gtc cca gat gat cag acc gca tgg 499 Ala Trp Arg Thr Phe Val Gly Leu Val Pro Asp Asp Gln Thr Ala Trp 120 125 130 ttg gcg cac caa ttg ctc caa gaa ttg gat aaa gga acg cct gaa att 547 Leu Ala His Gln Leu Leu Gln Glu Leu Asp Lys Gly Thr Pro Glu Ile 135 140 145 cag cgg agt tta agt cgg gcg atg gcg gaa ttg gag ggg agg gag gcg 595 Gln Arg Ser Leu Ser Arg Ala Met Ala Glu Leu Glu Gly Arg Glu Ala 150 155 160 165 tcg ata agc gtg ctt cta ggc gct tta acg agc gcg cac gcg gtg gcc 643 Ser Ile Ser Val Leu Leu Gly Ala Leu Thr Ser Ala His Ala Val Ala 170 175 180 acc gcc aag ctc att gcg gat ccg gac tcc gat ttc atg gct gat ctg 691 Thr Ala Lys Leu Ile Ala Asp Pro Asp Ser Asp Phe Met Ala Asp Leu 185 190 195 gag gaa gcg cgg cgc gtg gat aat atg ggt gca tgc tgatcggtga 737 Glu Glu Ala Arg Arg Val Asp Asn Met Gly Ala Cys 200 205 ggtgtccaag ctcagtgggg 757 <210> 322 <211> 209 <212> PRT <213> Corynebacterium glutamicum <400> 322 Met Asn Ile Ser Ala Met Asp Asn Phe Glu His Ser Asn Ala Ser Ile 1 5 10 15 Arg Leu Gln Ala Ala Leu Ala Ala Gly Thr Ala Glu Asp Thr Thr Ala 20 25 30 Ile Asp Ile Leu Leu Tyr Arg Ser Gly Val Glu Glu Asp Phe Phe Val 35 40 45 Arg Asp Met Ile Thr Trp Ala Leu Thr Arg Met Pro Val Asp Asp Val 50 55 60 Phe Thr Ser Leu Val Ala Asp Leu Asp Ser Glu Val Pro Asp Arg Pro 65 70 75 80 Phe Gly Ala Ser Gln Ala Leu His Thr Leu Ser Lys Leu Arg Val Ala 85 90 95 Gln Ser Trp Gln Glu Leu Gln Ala Arg Pro Trp Leu Leu His Arg Glu 100 105 110 Asp Thr Ala Gln Thr Ala Trp Arg Thr Phe Val Gly Leu Val Pro Asp 115 120 125 Asp Gln Thr Ala Trp Leu Ala His Gln Leu Leu Gln Glu Leu Asp Lys 130 135 140 Gly Thr Pro Glu Ile Gln Arg Ser Leu Ser Arg Ala Met Ala Glu Leu 145 150 155 160 Glu Gly Arg Glu Ala Ser Ile Ser Val Leu Leu Gly Ala Leu Thr Ser 165 170 175 Ala His Ala Val Ala Thr Ala Lys Leu Ile Ala Asp Pro Asp Ser Asp 180 185 190 Phe Met Ala Asp Leu Glu Glu Ala Arg Arg Val Asp Asn Met Gly Ala 195 200 205 Cys <210> 323 <211> 955 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(925) <223> RXA02735 <400> 323 accggctcga tcatcatcac catctatgac gctcataccc ttcaggtaga gatgccggaa 60 tccggcaatg ccccatcgct ggtggctatt ggtcgtcgaa gtg agt ccg act gct 115 Val Ser Pro Thr Ala 1 5 tgt ctg agg agc ttc gcc aca tgg atc cag att tgg gct acc agc acg 163 Cys Leu Arg Ser Phe Ala Thr Trp Ile Gln Ile Trp Ala Thr Ser Thr 10 15 20 cac tat ccg gct tgt cca gcg tca agc tgg aaa ccg tct aag gag aaa 211 His Tyr Pro Ala Cys Pro Ala Ser Ser Trp Lys Pro Ser Lys Glu Lys 25 30 35 tac aac act atg gtt gat gta gta cgc gca cgc gat act gaa gat ttg 259 Tyr Asn Thr Met Val Asp Val Val Arg Ala Arg Asp Thr Glu Asp Leu 40 45 50 gtt gca cag gct gcc tcc aaa ttc att gag gtt gtt gaa gca gca act 307 Val Ala Gln Ala Ala Ser Lys Phe Ile Glu Val Val Glu Ala Ala Thr 55 60 65 gcc aat aat ggc acc gca cag gta gtg ctc acc ggt ggt ggc gcc ggc 355 Ala Asn Asn Gly Thr Ala Gln Val Val Leu Thr Gly Gly Gly Ala Gly 70 75 80 85 atc aag ttg ctg gaa aag ctc agc gtt gat gcg gct gac ctt gcc tgg 403 Ile Lys Leu Leu Glu Lys Leu Ser Val Asp Ala Ala Asp Leu Ala Trp 90 95 100 gat cgc att cat gtg ttc ttc ggc gat gag cgc aat gtc cct gtc agt 451 Asp Arg Ile His Val Phe Phe Gly Asp Glu Arg Asn Val Pro Val Ser 105 110 115 gat tct gag tcc aat gag ggc cag gct cgt gag gca ctg ttg tcc aag 499 Asp Ser Glu Ser Asn Glu Gly Gln Ala Arg Glu Ala Leu Leu Ser Lys 120 125 130 gtt tct atc cct gaa gcc aac att cac gga tat ggt ctc ggc gac gta 547 Val Ser Ile Pro Glu Ala Asn Ile His Gly Tyr Gly Leu Gly Asp Val 135 140 145 gat ctt gca gag gca gcc cgc gct tac gaa gct gtg ttg gat gaa ttc 595 Asp Leu Ala Glu Ala Ala Arg Ala Tyr Glu Ala Val Leu Asp Glu Phe 150 155 160 165 gca cca aac ggc ttt gat ctt cac ctg ctc ggc atg ggt ggc gaa ggc 643 Ala Pro Asn Gly Phe Asp Leu His Leu Leu Gly Met Gly Gly Glu Gly 170 175 180 cat atc aac tcc ctg ttc cct cac acc gat gca gtc aag gaa tcc tcc 691 His Ile Asn Ser Leu Phe Pro His Thr Asp Ala Val Lys Glu Ser Ser 185 190 195 gca aag gtc atc gcg gtg ttt gat tcc cct aag cct cct tca gag cgt 739 Ala Lys Val Ile Ala Val Phe Asp Ser Pro Lys Pro Pro Ser Glu Arg 200 205 210 gca act cta acc ctt cct gcg gtt cac tcc gca aag cgc gtg tgg ttg 787 Ala Thr Leu Thr Leu Pro Ala Val His Ser Ala Lys Arg Val Trp Leu 215 220 225 ctg gtt tct ggt gcg gag aag gct gag gca gct gcg gcg atc gtc aac 835 Leu Val Ser Gly Ala Glu Lys Ala Glu Ala Ala Ala Ala Ile Val Asn 230 235 240 245 ggt gag cct gct gtt gag tgg cct gct gct gga gct acc gga tct gag 883 Gly Glu Pro Ala Val Glu Trp Pro Ala Ala Gly Ala Thr Gly Ser Glu 250 255 260 gaa acg gta ttg ttc ttg gct gat gat gct gca gga aat ctc 925 Glu Thr Val Leu Phe Leu Ala Asp Asp Ala Ala Gly Asn Leu 265 270 275 taagcagcgc cagctctaac aagaagcttt 955 <210> 324 <211> 275 <212> PRT <213> Corynebacterium glutamicum <400> 324 Val Ser Pro Thr Ala Cys Leu Arg Ser Phe Ala Thr Trp Ile Gln Ile 1 5 10 15 Trp Ala Thr Ser Thr His Tyr Pro Ala Cys Pro Ala Ser Ser Trp Lys 20 25 30 Pro Ser Lys Glu Lys Tyr Asn Thr Met Val Asp Val Val Arg Ala Arg 35 40 45 Asp Thr Glu Asp Leu Val Ala Gln Ala Ala Ser Lys Phe Ile Glu Val 50 55 60 Val Glu Ala Ala Thr Ala Asn Asn Gly Thr Ala Gln Val Val Leu Thr 65 70 75 80 Gly Gly Gly Ala Gly Ile Lys Leu Leu Glu Lys Leu Ser Val Asp Ala 85 90 95 Ala Asp Leu Ala Trp Asp Arg Ile His Val Phe Phe Gly Asp Glu Arg 100 105 110 Asn Val Pro Val Ser Asp Ser Glu Ser Asn Glu Gly Gln Ala Arg Glu 115 120 125 Ala Leu Leu Ser Lys Val Ser Ile Pro Glu Ala Asn Ile His Gly Tyr 130 135 140 Gly Leu Gly Asp Val Asp Leu Ala Glu Ala Ala Arg Ala Tyr Glu Ala 145 150 155 160 Val Leu Asp Glu Phe Ala Pro Asn Gly Phe Asp Leu His Leu Leu Gly 165 170 175 Met Gly Gly Glu Gly His Ile Asn Ser Leu Phe Pro His Thr Asp Ala 180 185 190 Val Lys Glu Ser Ser Ala Lys Val Ile Ala Val Phe Asp Ser Pro Lys 195 200 205 Pro Pro Ser Glu Arg Ala Thr Leu Thr Leu Pro Ala Val His Ser Ala 210 215 220 Lys Arg Val Trp Leu Leu Val Ser Gly Ala Glu Lys Ala Glu Ala Ala 225 230 235 240 Ala Ala Ile Val Asn Gly Glu Pro Ala Val Glu Trp Pro Ala Ala Gly 245 250 255 Ala Thr Gly Ser Glu Glu Thr Val Leu Phe Leu Ala Asp Asp Ala Ala 260 265 270 Gly Asn Leu 275 <210> 325 <211> 1087 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1057) <223> RXA02736 <400> 325 cagaggatta cccagcgggt acgtggggtc caaagagcgc tgatgaaatg ctttcccgca 60 acggtcacac ctggcgcagg ccataattta ggggcaaaaa atg atc ttt gaa ctt 115 Met Ile Phe Glu Leu 1 5 ccg gat acc acc acc cag caa att tcc aag acc cta act cga ctg cgt 163 Pro Asp Thr Thr Thr Gln Gln Ile Ser Lys Thr Leu Thr Arg Leu Arg 10 15 20 gaa tcg ggc acc cag gtc acc acc ggc cga gtg ctc acc ctc atc gtg 211 Glu Ser Gly Thr Gln Val Thr Thr Gly Arg Val Leu Thr Leu Ile Val 25 30 35 gtc act gac tcc gaa agc gat gtc gct gca gtt acc gag tcc acc aat 259 Val Thr Asp Ser Glu Ser Asp Val Ala Ala Val Thr Glu Ser Thr Asn 40 45 50 gaa gcc tcg cgc gag cac cca tct cgc gtg atc att ttg gtg gtt ggc 307 Glu Ala Ser Arg Glu His Pro Ser Arg Val Ile Ile Leu Val Val Gly 55 60 65 gat aaa act gca gaa aac aaa gtt gac gca gaa gtc cgt atc ggt ggc 355 Asp Lys Thr Ala Glu Asn Lys Val Asp Ala Glu Val Arg Ile Gly Gly 70 75 80 85 gac gct ggt gct tcc gag atg atc atc atg cat ctc aac gga cct gtc 403 Asp Ala Gly Ala Ser Glu Met Ile Ile Met His Leu Asn Gly Pro Val 90 95 100 gct gac aag ctc cag tat gtc gtc aca cca ctg ttg ctt cct gac acc 451 Ala Asp Lys Leu Gln Tyr Val Val Thr Pro Leu Leu Leu Pro Asp Thr 105 110 115 ccc atc gtt gct tgg tgg cca ggt gaa tca cca aag aat cct tcc cag 499 Pro Ile Val Ala Trp Trp Pro Gly Glu Ser Pro Lys Asn Pro Ser Gln 120 125 130 gac cca att gga cgc atc gca caa cga cgc atc act gat gct ttg tac 547 Asp Pro Ile Gly Arg Ile Ala Gln Arg Arg Ile Thr Asp Ala Leu Tyr 135 140 145 gac cgt gat gac gca cta gaa gat cgt gtt gag aac tat cac cca ggt 595 Asp Arg Asp Asp Ala Leu Glu Asp Arg Val Glu Asn Tyr His Pro Gly 150 155 160 165 gat acc gac atg acg tgg gcg cgc ctt acc cag tgg cgg gga ctt gtt 643 Asp Thr Asp Met Thr Trp Ala Arg Leu Thr Gln Trp Arg Gly Leu Val 170 175 180 gcc tcc tca ttg gat cac cca cca cac agc gaa atc act tcc gtg agg 691 Ala Ser Ser Leu Asp His Pro Pro His Ser Glu Ile Thr Ser Val Arg 185 190 195 ctg acc ggt gca agc ggc agt acc tcg gtg gat ttg gct gca ggc tgg 739 Leu Thr Gly Ala Ser Gly Ser Thr Ser Val Asp Leu Ala Ala Gly Trp 200 205 210 ttg gcg cgg agg ctg aaa gtg cct gtg atc cgc gag gtg aca gat gct 787 Leu Ala Arg Arg Leu Lys Val Pro Val Ile Arg Glu Val Thr Asp Ala 215 220 225 ccc acc gtg cca acc gat gag ttt ggt act cca ctg ctg gct atc cag 835 Pro Thr Val Pro Thr Asp Glu Phe Gly Thr Pro Leu Leu Ala Ile Gln 230 235 240 245 cgc ctg gag atc gtt cgc acc acc ggc tcg atc atc atc acc atc tat 883 Arg Leu Glu Ile Val Arg Thr Thr Gly Ser Ile Ile Ile Thr Ile Tyr 250 255 260 gac gct cat acc ctt cag gta gag atg ccg gaa tcc ggc aat gcc cca 931 Asp Ala His Thr Leu Gln Val Glu Met Pro Glu Ser Gly Asn Ala Pro 265 270 275 tcg ctg gtg gct att ggt cgt cga agt gag tcc gac tgc ttg tct gag 979 Ser Leu Val Ala Ile Gly Arg Arg Ser Glu Ser Asp Cys Leu Ser Glu 280 285 290 gag ctt cgc cac atg gat cca gat ttg ggc tac cag cac gca cta tcc 1027 Glu Leu Arg His Met Asp Pro Asp Leu Gly Tyr Gln His Ala Leu Ser 295 300 305 ggc ttg tcc agc gtc aag ctg gaa acc gtc taaggagaaa tacaacacta 1077 Gly Leu Ser Ser Val Lys Leu Glu Thr Val 310 315 tggttgatgt 1087 <210> 326 <211> 319 <212> PRT <213> Corynebacterium glutamicum <400> 326 Met Ile Phe Glu Leu Pro Asp Thr Thr Thr Gln Gln Ile Ser Lys Thr 1 5 10 15 Leu Thr Arg Leu Arg Glu Ser Gly Thr Gln Val Thr Thr Gly Arg Val 20 25 30 Leu Thr Leu Ile Val Val Thr Asp Ser Glu Ser Asp Val Ala Ala Val 35 40 45 Thr Glu Ser Thr Asn Glu Ala Ser Arg Glu His Pro Ser Arg Val Ile 50 55 60 Ile Leu Val Val Gly Asp Lys Thr Ala Glu Asn Lys Val Asp Ala Glu 65 70 75 80 Val Arg Ile Gly Gly Asp Ala Gly Ala Ser Glu Met Ile Ile Met His 85 90 95 Leu Asn Gly Pro Val Ala Asp Lys Leu Gln Tyr Val Val Thr Pro Leu 100 105 110 Leu Leu Pro Asp Thr Pro Ile Val Ala Trp Trp Pro Gly Glu Ser Pro 115 120 125 Lys Asn Pro Ser Gln Asp Pro Ile Gly Arg Ile Ala Gln Arg Arg Ile 130 135 140 Thr Asp Ala Leu Tyr Asp Arg Asp Asp Ala Leu Glu Asp Arg Val Glu 145 150 155 160 Asn Tyr His Pro Gly Asp Thr Asp Met Thr Trp Ala Arg Leu Thr Gln 165 170 175 Trp Arg Gly Leu Val Ala Ser Ser Leu Asp His Pro Pro His Ser Glu 180 185 190 Ile Thr Ser Val Arg Leu Thr Gly Ala Ser Gly Ser Thr Ser Val Asp 195 200 205 Leu Ala Ala Gly Trp Leu Ala Arg Arg Leu Lys Val Pro Val Ile Arg 210 215 220 Glu Val Thr Asp Ala Pro Thr Val Pro Thr Asp Glu Phe Gly Thr Pro 225 230 235 240 Leu Leu Ala Ile Gln Arg Leu Glu Ile Val Arg Thr Thr Gly Ser Ile 245 250 255 Ile Ile Thr Ile Tyr Asp Ala His Thr Leu Gln Val Glu Met Pro Glu 260 265 270 Ser Gly Asn Ala Pro Ser Leu Val Ala Ile Gly Arg Arg Ser Glu Ser 275 280 285 Asp Cys Leu Ser Glu Glu Leu Arg His Met Asp Pro Asp Leu Gly Tyr 290 295 300 Gln His Ala Leu Ser Gly Leu Ser Ser Val Lys Leu Glu Thr Val 305 310 315 <210> 327 <211> 934 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(904) <223> RXA02744 <400> 327 gccaaaacgt catgattcgc tctttggata cgggacaccg ctcattggaa gatgtcttcc 60 tggacatcac cggaaaagaa ctgaggagtt aacgcacacc atg tct aaa cct ttt 115 Met Ser Lys Pro Phe 1 5 gaa aac tct gcg ctc cgc ggt tct tct cga ttc cca gct gga acg ttc 163 Glu Asn Ser Ala Leu Arg Gly Ser Ser Arg Phe Pro Ala Gly Thr Phe 10 15 20 acc cct gct ccc aaa cga gcc acc ccg gca aaa atg ttg gct gct cag 211 Thr Pro Ala Pro Lys Arg Ala Thr Pro Ala Lys Met Leu Ala Ala Gln 25 30 35 ggc aag atg gaa tcc ctg ctg ttt ctt cgc cac ggc gaa cag caa ctg 259 Gly Lys Met Glu Ser Leu Leu Phe Leu Arg His Gly Glu Gln Gln Leu 40 45 50 ctc agc atc atc att ccc ttg gtc gcg ctc atc gca cta gcg aat ttt 307 Leu Ser Ile Ile Ile Pro Leu Val Ala Leu Ile Ala Leu Ala Asn Phe 55 60 65 gat ttc atc cct ggt gag aac tcc ctc gac aag act ttc ccc ttc gcg 355 Asp Phe Ile Pro Gly Glu Asn Ser Leu Asp Lys Thr Phe Pro Phe Ala 70 75 80 85 ctg gcc aca gca gcc atg agc gct ggt ttt aca ggt caa gcc atc agc 403 Leu Ala Thr Ala Ala Met Ser Ala Gly Phe Thr Gly Gln Ala Ile Ser 90 95 100 cta gct ttt gac cgc cgc tat ggt gcc ctc aag cgc acc ggc gcc agc 451 Leu Ala Phe Asp Arg Arg Tyr Gly Ala Leu Lys Arg Thr Gly Ala Ser 105 110 115 ggt gtt ccc gcc tgg acg att att ttt ggc aaa gtc atc gca gtc att 499 Gly Val Pro Ala Trp Thr Ile Ile Phe Gly Lys Val Ile Ala Val Ile 120 125 130 gca gtc acc att gtg cag atc atc ttt ctc ggt gtg act gca ctg ctg 547 Ala Val Thr Ile Val Gln Ile Ile Phe Leu Gly Val Thr Ala Leu Leu 135 140 145 ttg ggc tgg tcc gca cct gtc ggt ggt gtg ctc ttt ggc atc gtg acc 595 Leu Gly Trp Ser Ala Pro Val Gly Gly Val Leu Phe Gly Ile Val Thr 150 155 160 165 cta ttt gtg ggt gtt tcc agc ttc acc gcg ctc ggc atg ctg atg ggc 643 Leu Phe Val Gly Val Ser Ser Phe Thr Ala Leu Gly Met Leu Met Gly 170 175 180 gga acg ttg tcc tcc gaa ttg gta ttg gca ctg gct aac ttg att tgg 691 Gly Thr Leu Ser Ser Glu Leu Val Leu Ala Leu Ala Asn Leu Ile Trp 185 190 195 att gta ctg tcc ggc ctt gca gca tgg gcg gtc ttt tcc cct tcc gtc 739 Ile Val Leu Ser Gly Leu Ala Ala Trp Ala Val Phe Ser Pro Ser Val 200 205 210 aac gct gaa gga gtg ctg tcc atc atc cca tcc gtt gcg ctg tcc caa 787 Asn Ala Glu Gly Val Leu Ser Ile Ile Pro Ser Val Ala Leu Ser Gln 215 220 225 ggt atg gtt gac gca ttc aac ggc gaa ctt ccg tgg ctc cag cta gga 835 Gly Met Val Asp Ala Phe Asn Gly Glu Leu Pro Trp Leu Gln Leu Gly 230 235 240 245 att ttg gtg ggc tgg cta att atc acc ggc gtg gcc gca aac aag cta 883 Ile Leu Val Gly Trp Leu Ile Ile Thr Gly Val Ala Ala Asn Lys Leu 250 255 260 ttt aac ttc tct gcg agc cgc tagatatacc cttagtcgga aaatatcctt 934 Phe Asn Phe Ser Ala Ser Arg 265 <210> 328 <211> 268 <212> PRT <213> Corynebacterium glutamicum <400> 328 Met Ser Lys Pro Phe Glu Asn Ser Ala Leu Arg Gly Ser Ser Arg Phe 1 5 10 15 Pro Ala Gly Thr Phe Thr Pro Ala Pro Lys Arg Ala Thr Pro Ala Lys 20 25 30 Met Leu Ala Ala Gln Gly Lys Met Glu Ser Leu Leu Phe Leu Arg His 35 40 45 Gly Glu Gln Gln Leu Leu Ser Ile Ile Ile Pro Leu Val Ala Leu Ile 50 55 60 Ala Leu Ala Asn Phe Asp Phe Ile Pro Gly Glu Asn Ser Leu Asp Lys 65 70 75 80 Thr Phe Pro Phe Ala Leu Ala Thr Ala Ala Met Ser Ala Gly Phe Thr 85 90 95 Gly Gln Ala Ile Ser Leu Ala Phe Asp Arg Arg Tyr Gly Ala Leu Lys 100 105 110 Arg Thr Gly Ala Ser Gly Val Pro Ala Trp Thr Ile Ile Phe Gly Lys 115 120 125 Val Ile Ala Val Ile Ala Val Thr Ile Val Gln Ile Ile Phe Leu Gly 130 135 140 Val Thr Ala Leu Leu Leu Gly Trp Ser Ala Pro Val Gly Gly Val Leu 145 150 155 160 Phe Gly Ile Val Thr Leu Phe Val Gly Val Ser Ser Phe Thr Ala Leu 165 170 175 Gly Met Leu Met Gly Gly Thr Leu Ser Ser Glu Leu Val Leu Ala Leu 180 185 190 Ala Asn Leu Ile Trp Ile Val Leu Ser Gly Leu Ala Ala Trp Ala Val 195 200 205 Phe Ser Pro Ser Val Asn Ala Glu Gly Val Leu Ser Ile Ile Pro Ser 210 215 220 Val Ala Leu Ser Gln Gly Met Val Asp Ala Phe Asn Gly Glu Leu Pro 225 230 235 240 Trp Leu Gln Leu Gly Ile Leu Val Gly Trp Leu Ile Ile Thr Gly Val 245 250 255 Ala Ala Asn Lys Leu Phe Asn Phe Ser Ala Ser Arg 260 265 <210> 329 <211> 853 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(823) <223> RXA02757 <400> 329 ccattcctcg acgaggtttt gcacatcatg ggcatttccc gcgacgagat cgatctggcg 60 gatcaggaag acggcacttt ccaccgcgtt ccattgacca atg cct aaa gat tcg 115 Met Pro Lys Asp Ser 1 5 ctt ctc gac gcc cac ctc ctc ctc aag gcc cgg gct agc gac ggg cca 163 Leu Leu Asp Ala His Leu Leu Leu Lys Ala Arg Ala Ser Asp Gly Pro 10 15 20 cat agc gag gat cct tcg gat cct tcg acc gtt cag gca atg cag atc 211 His Ser Glu Asp Pro Ser Asp Pro Ser Thr Val Gln Ala Met Gln Ile 25 30 35 gcg ttg cac att ccg aaa cag aat ccg ccc cgg cgg aca gat gtg ttg 259 Ala Leu His Ile Pro Lys Gln Asn Pro Pro Arg Arg Thr Asp Val Leu 40 45 50 gaa gcg gcg gcg agg agt gtg gtc aag ctt tgc ctc gac gaa cga gta 307 Glu Ala Ala Ala Arg Ser Val Val Lys Leu Cys Leu Asp Glu Arg Val 55 60 65 tcc acc gat cct gat ttt cgg gcg gcc ttg gaa cgt tgg tac gga cac 355 Ser Thr Asp Pro Asp Phe Arg Ala Ala Leu Glu Arg Trp Tyr Gly His 70 75 80 85 ttg att cgg aag gtg tca cgt cgc gct cgt aat gcg gcg tgg gat cgg 403 Leu Ile Arg Lys Val Ser Arg Arg Ala Arg Asn Ala Ala Trp Asp Arg 90 95 100 gtg caa gat tta ccc ggc gtg act gtg gaa gat gat gct gca aag gtt 451 Val Gln Asp Leu Pro Gly Val Thr Val Glu Asp Asp Ala Ala Lys Val 105 110 115 cgg gca ttt ttg ccc agc gca gtg gtg gat gtg cct gca gat atc aaa 499 Arg Ala Phe Leu Pro Ser Ala Val Val Asp Val Pro Ala Asp Ile Lys 120 125 130 aag ctg cag att tcc ggt acg gaa ttg cct ctc gat gag ccg aat ccg 547 Lys Leu Gln Ile Ser Gly Thr Glu Leu Pro Leu Asp Glu Pro Asn Pro 135 140 145 atc aac gat gaa tac ccc gtt atc tac att gat gaa tcg ttg aag atg 595 Ile Asn Asp Glu Tyr Pro Val Ile Tyr Ile Asp Glu Ser Leu Lys Met 150 155 160 165 acg ctg gga aag gcc gct gcg cag gta gga cac gca tcc atg ttg ctt 643 Thr Leu Gly Lys Ala Ala Ala Gln Val Gly His Ala Ser Met Leu Leu 170 175 180 gcc gcg cac caa ccg ttt gag tgg gtg gag cag tgg gaa gca gcg gat 691 Ala Ala His Gln Pro Phe Glu Trp Val Glu Gln Trp Glu Ala Ala Asp 185 190 195 ttt gcg ctg cac gtc agg gag att ccc tcg gag gag ttc ctg cgc ctt 739 Phe Ala Leu His Val Arg Glu Ile Pro Ser Glu Glu Phe Leu Arg Leu 200 205 210 atc gag tct cct ggt gct gtt cca gtt cgc gat ggc ggc ttt act gag 787 Ile Glu Ser Pro Gly Ala Val Pro Val Arg Asp Gly Gly Phe Thr Glu 215 220 225 gtt gcc ccc aac acc gtg acg gtt gtt gca att cca taactaaacg 833 Val Ala Pro Asn Thr Val Thr Val Val Ala Ile Pro 230 235 240 agctttgatt aacaagtcct 853 <210> 330 <211> 241 <212> PRT <213> Corynebacterium glutamicum <400> 330 Met Pro Lys Asp Ser Leu Leu Asp Ala His Leu Leu Leu Lys Ala Arg 1 5 10 15 Ala Ser Asp Gly Pro His Ser Glu Asp Pro Ser Asp Pro Ser Thr Val 20 25 30 Gln Ala Met Gln Ile Ala Leu His Ile Pro Lys Gln Asn Pro Pro Arg 35 40 45 Arg Thr Asp Val Leu Glu Ala Ala Ala Arg Ser Val Val Lys Leu Cys 50 55 60 Leu Asp Glu Arg Val Ser Thr Asp Pro Asp Phe Arg Ala Ala Leu Glu 65 70 75 80 Arg Trp Tyr Gly His Leu Ile Arg Lys Val Ser Arg Arg Ala Arg Asn 85 90 95 Ala Ala Trp Asp Arg Val Gln Asp Leu Pro Gly Val Thr Val Glu Asp 100 105 110 Asp Ala Ala Lys Val Arg Ala Phe Leu Pro Ser Ala Val Val Asp Val 115 120 125 Pro Ala Asp Ile Lys Lys Leu Gln Ile Ser Gly Thr Glu Leu Pro Leu 130 135 140 Asp Glu Pro Asn Pro Ile Asn Asp Glu Tyr Pro Val Ile Tyr Ile Asp 145 150 155 160 Glu Ser Leu Lys Met Thr Leu Gly Lys Ala Ala Ala Gln Val Gly His 165 170 175 Ala Ser Met Leu Leu Ala Ala His Gln Pro Phe Glu Trp Val Glu Gln 180 185 190 Trp Glu Ala Ala Asp Phe Ala Leu His Val Arg Glu Ile Pro Ser Glu 195 200 205 Glu Phe Leu Arg Leu Ile Glu Ser Pro Gly Ala Val Pro Val Arg Asp 210 215 220 Gly Gly Phe Thr Glu Val Ala Pro Asn Thr Val Thr Val Val Ala Ile 225 230 235 240 Pro <210> 331 <211> 1237 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1207) <223> RXA02777 <400> 331 ggtcgcacca caccaactac tgtttcttct gtaatttgca ctgaaactat cgcctacact 60 gtcactgcta ccatcacaat cggttgctag taggctacaa atg aac cgc ccc ctt 115 Met Asn Arg Pro Leu 1 5 caa agt caa aat ttt tca ata acc agc gaa tgg gca aat gcc acg ttc 163 Gln Ser Gln Asn Phe Ser Ile Thr Ser Glu Trp Ala Asn Ala Thr Phe 10 15 20 aac gat atc gaa gac tct ttg gag ggg tct ttt gac atc gaa cca ggc 211 Asn Asp Ile Glu Asp Ser Leu Glu Gly Ser Phe Asp Ile Glu Pro Gly 25 30 35 caa tac att gga cgc gga gaa tac ttc gta gct act tct gga acg ggt 259 Gln Tyr Ile Gly Arg Gly Glu Tyr Phe Val Ala Thr Ser Gly Thr Gly 40 45 50 tcc aaa aag ttt atc aag gtg gtt ttg ggt gac ggt atc gat agc gaa 307 Ser Lys Lys Phe Ile Lys Val Val Leu Gly Asp Gly Ile Asp Ser Glu 55 60 65 cta aat cgt cgc atc gaa ggt gaa att ctt gca agt agt ctc cat ctt 355 Leu Asn Arg Arg Ile Glu Gly Glu Ile Leu Ala Ser Ser Leu His Leu 70 75 80 85 cca tcc aca gac cta atc tct cct gtc gta att cag tat gtg aaa gag 403 Pro Ser Thr Asp Leu Ile Ser Pro Val Val Ile Gln Tyr Val Lys Glu 90 95 100 tct tct aat ttt ccc ggt gac ttc tac atc gtg tcc gac ttc aaa gac 451 Ser Ser Asn Phe Pro Gly Asp Phe Tyr Ile Val Ser Asp Phe Lys Asp 105 110 115 gac aca gaa act tta gag cta tct aag gct tct cta ccc ctc act gac 499 Asp Thr Glu Thr Leu Glu Leu Ser Lys Ala Ser Leu Pro Leu Thr Asp 120 125 130 tta gcc aag atc gga gcg ttt ctc ttt cgt ttg gaa tct gta aca gtt 547 Leu Ala Lys Ile Gly Ala Phe Leu Phe Arg Leu Glu Ser Val Thr Val 135 140 145 ccc cct caa aat cct gca agg cga gca atg gat gtt ttg gat gga ctt 595 Pro Pro Gln Asn Pro Ala Arg Arg Ala Met Asp Val Leu Asp Gly Leu 150 155 160 165 tct ctt ctt gca aat aaa ggc aac att gaa aca ggc gca caa tta aca 643 Ser Leu Leu Ala Asn Lys Gly Asn Ile Glu Thr Gly Ala Gln Leu Thr 170 175 180 aaa gga act ata caa gct ctt gaa atc att aat caa gaa gcg acc aac 691 Lys Gly Thr Ile Gln Ala Leu Glu Ile Ile Asn Gln Glu Ala Thr Asn 185 190 195 atc gag aat gca ctt gaa aaa gta act aaa gta gga tca cgg aag ttt 739 Ile Glu Asn Ala Leu Glu Lys Val Thr Lys Val Gly Ser Arg Lys Phe 200 205 210 ttc tcg cat gga gat ctt aaa ttt tct cag ttc tta att aat ggt gaa 787 Phe Ser His Gly Asp Leu Lys Phe Ser Gln Phe Leu Ile Asn Gly Glu 215 220 225 acc gga aag att ttc cta tgt gac tgg gaa gaa tgc ggt agt gca cat 835 Thr Gly Lys Ile Phe Leu Cys Asp Trp Glu Glu Cys Gly Ser Ala His 230 235 240 245 ttc gca aat gac cta tgt ttt ctc gca ggt gat ttg ttc tat agc aca 883 Phe Ala Asn Asp Leu Cys Phe Leu Ala Gly Asp Leu Phe Tyr Ser Thr 250 255 260 att cgg gaa ctg gtg gat acc aac atc aaa aac att aaa ggc tcc tcg 931 Ile Arg Glu Leu Val Asp Thr Asn Ile Lys Asn Ile Lys Gly Ser Ser 265 270 275 atc att cag gaa gcc tac gat aat gca acg ctt gag gct gta tca aaa 979 Ile Ile Gln Glu Ala Tyr Asp Asn Ala Thr Leu Glu Ala Val Ser Lys 280 285 290 gta aat gca ata tta act ggc tat tcc tca gag agg ggt tac tct ctc 1027 Val Asn Ala Ile Leu Thr Gly Tyr Ser Ser Glu Arg Gly Tyr Ser Leu 295 300 305 acc tcg gac gaa aaa cga atc att agt atc aga atc gga ttg gct ggt 1075 Thr Ser Asp Glu Lys Arg Ile Ile Ser Ile Arg Ile Gly Leu Ala Gly 310 315 320 325 cta ttt cga ctt tac act gtg agc gct aaa tct aat gag tta cgc ccg 1123 Leu Phe Arg Leu Tyr Thr Val Ser Ala Lys Ser Asn Glu Leu Arg Pro 330 335 340 cgc gaa tta gcc tta gcc tcc atc gga atg caa att act tta ggt caa 1171 Arg Glu Leu Ala Leu Ala Ser Ile Gly Met Gln Ile Thr Leu Gly Gln 345 350 355 gca ccc aat ctg gtg ttt aca gat agc aag gtg gtt taagtgagga 1217 Ala Pro Asn Leu Val Phe Thr Asp Ser Lys Val Val 360 365 atttgcacga aacgatagac 1237 <210> 332 <211> 369 <212> PRT <213> Corynebacterium glutamicum <400> 332 Met Asn Arg Pro Leu Gln Ser Gln Asn Phe Ser Ile Thr Ser Glu Trp 1 5 10 15 Ala Asn Ala Thr Phe Asn Asp Ile Glu Asp Ser Leu Glu Gly Ser Phe 20 25 30 Asp Ile Glu Pro Gly Gln Tyr Ile Gly Arg Gly Glu Tyr Phe Val Ala 35 40 45 Thr Ser Gly Thr Gly Ser Lys Lys Phe Ile Lys Val Val Leu Gly Asp 50 55 60 Gly Ile Asp Ser Glu Leu Asn Arg Arg Ile Glu Gly Glu Ile Leu Ala 65 70 75 80 Ser Ser Leu His Leu Pro Ser Thr Asp Leu Ile Ser Pro Val Val Ile 85 90 95 Gln Tyr Val Lys Glu Ser Ser Asn Phe Pro Gly Asp Phe Tyr Ile Val 100 105 110 Ser Asp Phe Lys Asp Asp Thr Glu Thr Leu Glu Leu Ser Lys Ala Ser 115 120 125 Leu Pro Leu Thr Asp Leu Ala Lys Ile Gly Ala Phe Leu Phe Arg Leu 130 135 140 Glu Ser Val Thr Val Pro Pro Gln Asn Pro Ala Arg Arg Ala Met Asp 145 150 155 160 Val Leu Asp Gly Leu Ser Leu Leu Ala Asn Lys Gly Asn Ile Glu Thr 165 170 175 Gly Ala Gln Leu Thr Lys Gly Thr Ile Gln Ala Leu Glu Ile Ile Asn 180 185 190 Gln Glu Ala Thr Asn Ile Glu Asn Ala Leu Glu Lys Val Thr Lys Val 195 200 205 Gly Ser Arg Lys Phe Phe Ser His Gly Asp Leu Lys Phe Ser Gln Phe 210 215 220 Leu Ile Asn Gly Glu Thr Gly Lys Ile Phe Leu Cys Asp Trp Glu Glu 225 230 235 240 Cys Gly Ser Ala His Phe Ala Asn Asp Leu Cys Phe Leu Ala Gly Asp 245 250 255 Leu Phe Tyr Ser Thr Ile Arg Glu Leu Val Asp Thr Asn Ile Lys Asn 260 265 270 Ile Lys Gly Ser Ser Ile Ile Gln Glu Ala Tyr Asp Asn Ala Thr Leu 275 280 285 Glu Ala Val Ser Lys Val Asn Ala Ile Leu Thr Gly Tyr Ser Ser Glu 290 295 300 Arg Gly Tyr Ser Leu Thr Ser Asp Glu Lys Arg Ile Ile Ser Ile Arg 305 310 315 320 Ile Gly Leu Ala Gly Leu Phe Arg Leu Tyr Thr Val Ser Ala Lys Ser 325 330 335 Asn Glu Leu Arg Pro Arg Glu Leu Ala Leu Ala Ser Ile Gly Met Gln 340 345 350 Ile Thr Leu Gly Gln Ala Pro Asn Leu Val Phe Thr Asp Ser Lys Val 355 360 365 Val <210> 333 <211> 316 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(286) <223> RXA02784 <400> 333 agctgcaact caggtagaag aaacaacagt cgcccgagtt gaacacgata cttacgacac 60 tattgctaac cagctacaag atgccggtgt ctatgacgat gtg gcc ttt gcc gaa 115 Val Ala Phe Ala Glu 1 5 ggc tac tac cag gaa atg gct gag gtt gta tgt gaa gca cgc gaa gag 163 Gly Tyr Tyr Gln Glu Met Ala Glu Val Val Cys Glu Ala Arg Glu Glu 10 15 20 ggt atc acc cac gag gac acc ctg cat atg ctc aat gac atg atg gca 211 Gly Ile Thr His Glu Asp Thr Leu His Met Leu Asn Asp Met Met Ala 25 30 35 atg aaa cga tct ggc gaa gta ctc aat acg ctc gct gat gtt ctc tat 259 Met Lys Arg Ser Gly Glu Val Leu Asn Thr Leu Ala Asp Val Leu Tyr 40 45 50 gca aat gaa tgc cct gaa tat cga atc taaattgttg gttcactctg 306 Ala Asn Glu Cys Pro Glu Tyr Arg Ile 55 60 catagacaca 316 <210> 334 <211> 62 <212> PRT <213> Corynebacterium glutamicum <400> 334 Val Ala Phe Ala Glu Gly Tyr Tyr Gln Glu Met Ala Glu Val Val Cys 1 5 10 15 Glu Ala Arg Glu Glu Gly Ile Thr His Glu Asp Thr Leu His Met Leu 20 25 30 Asn Asp Met Met Ala Met Lys Arg Ser Gly Glu Val Leu Asn Thr Leu 35 40 45 Ala Asp Val Leu Tyr Ala Asn Glu Cys Pro Glu Tyr Arg Ile 50 55 60 <210> 335 <211> 1354 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1324) <223> RXA02786 <400> 335 atagaatgag gaaatatgcg cttccgcgcc gatcaaattc attgattgtt aatcggaagt 60 tttttgaaca ggtaaagcta ggggacctgt tcagtgcctg ttg gcg gat gta tta 115 Leu Ala Asp Val Leu 1 5 agg aga atg ccc atg ctg agc cac gaa gaa att gtt gcg atc gca gaa 163 Arg Arg Met Pro Met Leu Ser His Glu Glu Ile Val Ala Ile Ala Glu 10 15 20 gat ttg ctg tct aaa cgc tac ggc ggt gta caa act ctt tct gac gtg 211 Asp Leu Leu Ser Lys Arg Tyr Gly Gly Val Gln Thr Leu Ser Asp Val 25 30 35 gag cag ctc aac ggt tcc ggc acc tcc gcg gtg ctg cgt gcc agg gtg 259 Glu Gln Leu Asn Gly Ser Gly Thr Ser Ala Val Leu Arg Ala Arg Val 40 45 50 gct aac tcc cca ttc ctc caa cag cgc tcc gtg gtg ctg aag tac gtg 307 Ala Asn Ser Pro Phe Leu Gln Gln Arg Ser Val Val Leu Lys Tyr Val 55 60 65 ccc agc acc gga gac gtc ttt gat gat tct gcg ctg gtg cgt gaa atc 355 Pro Ser Thr Gly Asp Val Phe Asp Asp Ser Ala Leu Val Arg Glu Ile 70 75 80 85 gtc tcc tac cag ttc acc acc tcc ttg tcg gaa gat gtc cgc cca ggg 403 Val Ser Tyr Gln Phe Thr Thr Ser Leu Ser Glu Asp Val Arg Pro Gly 90 95 100 cca gtc att ttg gcc tat gac att gac aag cgc atc ctg gtc att tca 451 Pro Val Ile Leu Ala Tyr Asp Ile Asp Lys Arg Ile Leu Val Ile Ser 105 110 115 gat tcc ggc aac ggc gac acc ttt gcg gat ctg atc gat cag cgt acc 499 Asp Ser Gly Asn Gly Asp Thr Phe Ala Asp Leu Ile Asp Gln Arg Thr 120 125 130 ggt gat cag cgc atg cag atc ctg cgc aac ctc ggc caa tcg ctg ggc 547 Gly Asp Gln Arg Met Gln Ile Leu Arg Asn Leu Gly Gln Ser Leu Gly 135 140 145 agc ctg cac gcc gcc acc gca gac cgc gaa gaa gac ttc aac att ctg 595 Ser Leu His Ala Ala Thr Ala Asp Arg Glu Glu Asp Phe Asn Ile Leu 150 155 160 165 ctc aac cgt atg ctg gcc aaa tac cca gcc aca gct gag atg cag aaa 643 Leu Asn Arg Met Leu Ala Lys Tyr Pro Ala Thr Ala Glu Met Gln Lys 170 175 180 aac cgc gat agg ttg ctg ccc gca gca att gag gtg ggt aaa aag ata 691 Asn Arg Asp Arg Leu Leu Pro Ala Ala Ile Glu Val Gly Lys Lys Ile 185 190 195 ctt gtc gac gcc ggg gtc acc gtt cca gaa gtc gtc gag gag ttt gcc 739 Leu Val Asp Ala Gly Val Thr Val Pro Glu Val Val Glu Glu Phe Ala 200 205 210 cgc gta gct cgg cga cgc ctg att tcc gga cgc cac cgt gcc ttc aca 787 Arg Val Ala Arg Arg Arg Leu Ile Ser Gly Arg His Arg Ala Phe Thr 215 220 225 cct ttt gac ttg tca ccc gac aac atc atc gtg gct gaa cgc acc cac 835 Pro Phe Asp Leu Ser Pro Asp Asn Ile Ile Val Ala Glu Arg Thr His 230 235 240 245 ttc ctg gac tac gaa gtt gcc ggt ttc agg gat gcc acc ttt gat gtt 883 Phe Leu Asp Tyr Glu Val Ala Gly Phe Arg Asp Ala Thr Phe Asp Val 250 255 260 gct tgt gtg atc gca ggt ttc ccg caa ttc gtg ttc agc cgc ccc atc 931 Ala Cys Val Ile Ala Gly Phe Pro Gln Phe Val Phe Ser Arg Pro Ile 265 270 275 tct gat gat gag gta gac gaa ctc att gaa tcc tgg gtc caa gaa gtc 979 Ser Asp Asp Glu Val Asp Glu Leu Ile Glu Ser Trp Val Gln Glu Val 280 285 290 cgt gga atc tgg ccc aat gtg aac aat gaa gag cgc ctc caa gca cgt 1027 Arg Gly Ile Trp Pro Asn Val Asn Asn Glu Glu Arg Leu Gln Ala Arg 295 300 305 atc gtg acc gct ctc atc ggc tgg gca cta tcg agt gtt gcc ttc atg 1075 Ile Val Thr Ala Leu Ile Gly Trp Ala Leu Ser Ser Val Ala Phe Met 310 315 320 325 aag ctc ggc tcc atc agc ggc atg ctt aac ctg ctg cac gtc acc gaa 1123 Lys Leu Gly Ser Ile Ser Gly Met Leu Asn Leu Leu His Val Thr Glu 330 335 340 gat gga aac acc act ttg gat gtc tcc aac ctt gat gaa ctg ttg att 1171 Asp Gly Asn Thr Thr Leu Asp Val Ser Asn Leu Asp Glu Leu Leu Ile 345 350 355 cca cga tct gcc gaa gat gac gag ctg gtc cag caa gac ctc cac gac 1219 Pro Arg Ser Ala Glu Asp Asp Glu Leu Val Gln Gln Asp Leu His Asp 360 365 370 acg ttc tcc gcg ctt cag cga ttt gca gcg cgc ggg ctg gat tcc agg 1267 Thr Phe Ser Ala Leu Gln Arg Phe Ala Ala Arg Gly Leu Asp Ser Arg 375 380 385 ttc cct gag gtg gca cga ttc gca gac gac gtg gtg cgt ttg ttc ctc 1315 Phe Pro Glu Val Ala Arg Phe Ala Asp Asp Val Val Arg Leu Phe Leu 390 395 400 405 aaa aat gac tagctgaaga gcaccggttg cttggttgtt 1354 Lys Asn Asp <210> 336 <211> 408 <212> PRT <213> Corynebacterium glutamicum <400> 336 Leu Ala Asp Val Leu Arg Arg Met Pro Met Leu Ser His Glu Glu Ile 1 5 10 15 Val Ala Ile Ala Glu Asp Leu Leu Ser Lys Arg Tyr Gly Gly Val Gln 20 25 30 Thr Leu Ser Asp Val Glu Gln Leu Asn Gly Ser Gly Thr Ser Ala Val 35 40 45 Leu Arg Ala Arg Val Ala Asn Ser Pro Phe Leu Gln Gln Arg Ser Val 50 55 60 Val Leu Lys Tyr Val Pro Ser Thr Gly Asp Val Phe Asp Asp Ser Ala 65 70 75 80 Leu Val Arg Glu Ile Val Ser Tyr Gln Phe Thr Thr Ser Leu Ser Glu 85 90 95 Asp Val Arg Pro Gly Pro Val Ile Leu Ala Tyr Asp Ile Asp Lys Arg 100 105 110 Ile Leu Val Ile Ser Asp Ser Gly Asn Gly Asp Thr Phe Ala Asp Leu 115 120 125 Ile Asp Gln Arg Thr Gly Asp Gln Arg Met Gln Ile Leu Arg Asn Leu 130 135 140 Gly Gln Ser Leu Gly Ser Leu His Ala Ala Thr Ala Asp Arg Glu Glu 145 150 155 160 Asp Phe Asn Ile Leu Leu Asn Arg Met Leu Ala Lys Tyr Pro Ala Thr 165 170 175 Ala Glu Met Gln Lys Asn Arg Asp Arg Leu Leu Pro Ala Ala Ile Glu 180 185 190 Val Gly Lys Lys Ile Leu Val Asp Ala Gly Val Thr Val Pro Glu Val 195 200 205 Val Glu Glu Phe Ala Arg Val Ala Arg Arg Arg Leu Ile Ser Gly Arg 210 215 220 His Arg Ala Phe Thr Pro Phe Asp Leu Ser Pro Asp Asn Ile Ile Val 225 230 235 240 Ala Glu Arg Thr His Phe Leu Asp Tyr Glu Val Ala Gly Phe Arg Asp 245 250 255 Ala Thr Phe Asp Val Ala Cys Val Ile Ala Gly Phe Pro Gln Phe Val 260 265 270 Phe Ser Arg Pro Ile Ser Asp Asp Glu Val Asp Glu Leu Ile Glu Ser 275 280 285 Trp Val Gln Glu Val Arg Gly Ile Trp Pro Asn Val Asn Asn Glu Glu 290 295 300 Arg Leu Gln Ala Arg Ile Val Thr Ala Leu Ile Gly Trp Ala Leu Ser 305 310 315 320 Ser Val Ala Phe Met Lys Leu Gly Ser Ile Ser Gly Met Leu Asn Leu 325 330 335 Leu His Val Thr Glu Asp Gly Asn Thr Thr Leu Asp Val Ser Asn Leu 340 345 350 Asp Glu Leu Leu Ile Pro Arg Ser Ala Glu Asp Asp Glu Leu Val Gln 355 360 365 Gln Asp Leu His Asp Thr Phe Ser Ala Leu Gln Arg Phe Ala Ala Arg 370 375 380 Gly Leu Asp Ser Arg Phe Pro Glu Val Ala Arg Phe Ala Asp Asp Val 385 390 395 400 Val Arg Leu Phe Leu Lys Asn Asp 405 <210> 337 <211> 1555 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1525) <223> RXA02798 <400> 337 gcatcaaaat catgtgcatt catcattgct gatcatcata gacctgttgg caaatgaatt 60 caccaattct ttaaagctct caccctcttt agggaactga atg cgg tct gta ctc 115 Met Arg Ser Val Leu 1 5 gac tac tgg atc atg act ctt gca cct tcc acc aat gcg gtt tcg cag 163 Asp Tyr Trp Ile Met Thr Leu Ala Pro Ser Thr Asn Ala Val Ser Gln 10 15 20 caa aca aga agg aac cct tcc caa gcg ccg cga ctt ctt cat cga ctt 211 Gln Thr Arg Arg Asn Pro Ser Gln Ala Pro Arg Leu Leu His Arg Leu 25 30 35 cac ttc ttt gcc ggc att atc tgc gca ccg ttg att ttc atc gct gcg 259 His Phe Phe Ala Gly Ile Ile Cys Ala Pro Leu Ile Phe Ile Ala Ala 40 45 50 ctc acc gga ctg gtg tat gcg ttc tcc ccc acc att gaa agc atc tct 307 Leu Thr Gly Leu Val Tyr Ala Phe Ser Pro Thr Ile Glu Ser Ile Ser 55 60 65 aat cag gaa atg ctc acg gtc tcc aag tcg gct agc gac aca gct ctt 355 Asn Gln Glu Met Leu Thr Val Ser Lys Ser Ala Ser Asp Thr Ala Leu 70 75 80 85 ccg gtg cgt gaa caa gtg agc atc gcc caa gaa ctc cac ccc gat tta 403 Pro Val Arg Glu Gln Val Ser Ile Ala Gln Glu Leu His Pro Asp Leu 90 95 100 gat ctc tca ggt gtc cgg ctt ggc gat gat tcc tcc acc acc cgc gtc 451 Asp Leu Ser Gly Val Arg Leu Gly Asp Asp Ser Ser Thr Thr Arg Val 105 110 115 ctc ttc gcc gac gag acg ctt gct gaa tcc aca gtc cgc gcc gtg ttt 499 Leu Phe Ala Asp Glu Thr Leu Ala Glu Ser Thr Val Arg Ala Val Phe 120 125 130 gtt gat ccc tac acc ggc gag atc acc ggt gat acc acc caa tac gga 547 Val Asp Pro Tyr Thr Gly Glu Ile Thr Gly Asp Thr Thr Gln Tyr Gly 135 140 145 agc tca gct gca ctg ccg ttt cgg caa tgg gtc tcg caa ggt cac cgc 595 Ser Ser Ala Ala Leu Pro Phe Arg Gln Trp Val Ser Gln Gly His Arg 150 155 160 165 atg ttg tgg ctt ggt gaa cct gga cgt att tat tcc gaa ctt gcg gca 643 Met Leu Trp Leu Gly Glu Pro Gly Arg Ile Tyr Ser Glu Leu Ala Ala 170 175 180 agt tgg ctc gga gtt tta gcc gta ggc ggt ttc gca tta ttg tgg ttg 691 Ser Trp Leu Gly Val Leu Ala Val Gly Gly Phe Ala Leu Leu Trp Leu 185 190 195 cgc aac aaa aag ccc ggc cgc ttg aga aag atg gtg cga act ggt ggc 739 Arg Asn Lys Lys Pro Gly Arg Leu Arg Lys Met Val Arg Thr Gly Gly 200 205 210 cgt ggt cga gtg aaa acg tat cgc cga cat gca gca ttg ggc acc gta 787 Arg Gly Arg Val Lys Thr Tyr Arg Arg His Ala Ala Leu Gly Thr Val 215 220 225 gcg ggc ttg ggt ttt gtg ttc ctc acc ttt act ggc ctg acc tgg tca 835 Ala Gly Leu Gly Phe Val Phe Leu Thr Phe Thr Gly Leu Thr Trp Ser 230 235 240 245 act tat gcg gga tcc aac atc acg gat tta cgc acc caa ctc aat tgg 883 Thr Tyr Ala Gly Ser Asn Ile Thr Asp Leu Arg Thr Gln Leu Asn Trp 250 255 260 acg cag cct tcc gtt aac gct tct cta aca gct gcc cca caa gtg gac 931 Thr Gln Pro Ser Val Asn Ala Ser Leu Thr Ala Ala Pro Gln Val Asp 265 270 275 atg cat gat gaa cac gca ggt cat cac atg cat atg gag tcg gca acc 979 Met His Asp Glu His Ala Gly His His Met His Met Glu Ser Ala Thr 280 285 290 tca ggc tca ggt tct ata gat ctg gta gcg gcc acg gct atc tcc gaa 1027 Ser Gly Ser Gly Ser Ile Asp Leu Val Ala Ala Thr Ala Ile Ser Glu 295 300 305 tta cgc act ccc ctc acc att act ccc cca gca caa gat ggc ctc gcg 1075 Leu Arg Thr Pro Leu Thr Ile Thr Pro Pro Ala Gln Asp Gly Leu Ala 310 315 320 325 tgg act gcc aca gaa aac cgc gac gcc tac cga ttc acc act gac acc 1123 Trp Thr Ala Thr Glu Asn Arg Asp Ala Tyr Arg Phe Thr Thr Asp Thr 330 335 340 atc gct gtt gat ggc gac acc gga atg ctg acc aac cgt ttg aat tcc 1171 Ile Ala Val Asp Gly Asp Thr Gly Met Leu Thr Asn Arg Leu Asn Ser 345 350 355 act gat tgg cca tta gct gct caa gcg agt gca tgg ctc atc cag ctt 1219 Thr Asp Trp Pro Leu Ala Ala Gln Ala Ser Ala Trp Leu Ile Gln Leu 360 365 370 cac atg ggc acc ctg ttt ggc ctt ccc aac cag gtt gta ctt ggg ctg 1267 His Met Gly Thr Leu Phe Gly Leu Pro Asn Gln Val Val Leu Gly Leu 375 380 385 ttg gct gcc tca ata atc gtg atg atc ggc ctt ggg tat tgg atg ctg 1315 Leu Ala Ala Ser Ile Ile Val Met Ile Gly Leu Gly Tyr Trp Met Leu 390 395 400 405 tgg cag cat cgg cca cgg gaa ggt tgg cct agc gct ccc aag cgt gca 1363 Trp Gln His Arg Pro Arg Glu Gly Trp Pro Ser Ala Pro Lys Arg Ala 410 415 420 gga ttt gaa aaa ccc acc tgg gga act atc gcg ttg ggt gtt gtg gtg 1411 Gly Phe Glu Lys Pro Thr Trp Gly Thr Ile Ala Leu Gly Val Val Val 425 430 435 atc gcg tat ggg ctt ctc gcg cca ctt ttt gca gtt tca ctg ctc gtg 1459 Ile Ala Tyr Gly Leu Leu Ala Pro Leu Phe Ala Val Ser Leu Leu Val 440 445 450 ttt att gga tta agc ctt gga gtg cgg ttt att tct cgt atg tcc ggg 1507 Phe Ile Gly Leu Ser Leu Gly Val Arg Phe Ile Ser Arg Met Ser Gly 455 460 465 cgc gcg gac acg tcc aac taagaacacc aaaccacacc gcccacgaat 1555 Arg Ala Asp Thr Ser Asn 470 475 <210> 338 <211> 475 <212> PRT <213> Corynebacterium glutamicum <400> 338 Met Arg Ser Val Leu Asp Tyr Trp Ile Met Thr Leu Ala Pro Ser Thr 1 5 10 15 Asn Ala Val Ser Gln Gln Thr Arg Arg Asn Pro Ser Gln Ala Pro Arg 20 25 30 Leu Leu His Arg Leu His Phe Phe Ala Gly Ile Ile Cys Ala Pro Leu 35 40 45 Ile Phe Ile Ala Ala Leu Thr Gly Leu Val Tyr Ala Phe Ser Pro Thr 50 55 60 Ile Glu Ser Ile Ser Asn Gln Glu Met Leu Thr Val Ser Lys Ser Ala 65 70 75 80 Ser Asp Thr Ala Leu Pro Val Arg Glu Gln Val Ser Ile Ala Gln Glu 85 90 95 Leu His Pro Asp Leu Asp Leu Ser Gly Val Arg Leu Gly Asp Asp Ser 100 105 110 Ser Thr Thr Arg Val Leu Phe Ala Asp Glu Thr Leu Ala Glu Ser Thr 115 120 125 Val Arg Ala Val Phe Val Asp Pro Tyr Thr Gly Glu Ile Thr Gly Asp 130 135 140 Thr Thr Gln Tyr Gly Ser Ser Ala Ala Leu Pro Phe Arg Gln Trp Val 145 150 155 160 Ser Gln Gly His Arg Met Leu Trp Leu Gly Glu Pro Gly Arg Ile Tyr 165 170 175 Ser Glu Leu Ala Ala Ser Trp Leu Gly Val Leu Ala Val Gly Gly Phe 180 185 190 Ala Leu Leu Trp Leu Arg Asn Lys Lys Pro Gly Arg Leu Arg Lys Met 195 200 205 Val Arg Thr Gly Gly Arg Gly Arg Val Lys Thr Tyr Arg Arg His Ala 210 215 220 Ala Leu Gly Thr Val Ala Gly Leu Gly Phe Val Phe Leu Thr Phe Thr 225 230 235 240 Gly Leu Thr Trp Ser Thr Tyr Ala Gly Ser Asn Ile Thr Asp Leu Arg 245 250 255 Thr Gln Leu Asn Trp Thr Gln Pro Ser Val Asn Ala Ser Leu Thr Ala 260 265 270 Ala Pro Gln Val Asp Met His Asp Glu His Ala Gly His His Met His 275 280 285 Met Glu Ser Ala Thr Ser Gly Ser Gly Ser Ile Asp Leu Val Ala Ala 290 295 300 Thr Ala Ile Ser Glu Leu Arg Thr Pro Leu Thr Ile Thr Pro Pro Ala 305 310 315 320 Gln Asp Gly Leu Ala Trp Thr Ala Thr Glu Asn Arg Asp Ala Tyr Arg 325 330 335 Phe Thr Thr Asp Thr Ile Ala Val Asp Gly Asp Thr Gly Met Leu Thr 340 345 350 Asn Arg Leu Asn Ser Thr Asp Trp Pro Leu Ala Ala Gln Ala Ser Ala 355 360 365 Trp Leu Ile Gln Leu His Met Gly Thr Leu Phe Gly Leu Pro Asn Gln 370 375 380 Val Val Leu Gly Leu Leu Ala Ala Ser Ile Ile Val Met Ile Gly Leu 385 390 395 400 Gly Tyr Trp Met Leu Trp Gln His Arg Pro Arg Glu Gly Trp Pro Ser 405 410 415 Ala Pro Lys Arg Ala Gly Phe Glu Lys Pro Thr Trp Gly Thr Ile Ala 420 425 430 Leu Gly Val Val Val Ile Ala Tyr Gly Leu Leu Ala Pro Leu Phe Ala 435 440 445 Val Ser Leu Leu Val Phe Ile Gly Leu Ser Leu Gly Val Arg Phe Ile 450 455 460 Ser Arg Met Ser Gly Arg Ala Asp Thr Ser Asn 465 470 475 <210> 339 <211> 1729 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1699) <223> RXA02817 <400> 339 aaaattccca cccccaaaac tcccccactt cggttaagga atcaggattc tcacaaagtt 60 caggcaggct cccgctactt ttcagcgcta atcttggctc atg att tta ggc gta 115 Met Ile Leu Gly Val 1 5 ccc att caa tat ttg ctc tat tca ttg tgg aat tgg att gtc gat acc 163 Pro Ile Gln Tyr Leu Leu Tyr Ser Leu Trp Asn Trp Ile Val Asp Thr 10 15 20 ggt ttt gat gta gca att atc ctg gtc ttg gcg ttt ttg att cca cgt 211 Gly Phe Asp Val Ala Ile Ile Leu Val Leu Ala Phe Leu Ile Pro Arg 25 30 35 atc ggc cga ctg gcc atg cgt att atc aag cgc cga gtg gag tct gca 259 Ile Gly Arg Leu Ala Met Arg Ile Ile Lys Arg Arg Val Glu Ser Ala 40 45 50 gcc gat gcg gac acc act aag aac cag ctc gcg ttc gcc ggc gtt ggc 307 Ala Asp Ala Asp Thr Thr Lys Asn Gln Leu Ala Phe Ala Gly Val Gly 55 60 65 gtt tat atc gcg caa att gtg gcg ttt ttc atg ctt gcc gtc tcc gcg 355 Val Tyr Ile Ala Gln Ile Val Ala Phe Phe Met Leu Ala Val Ser Ala 70 75 80 85 atg cag gct ttt ggt ttc tct ctc gcg ggc gct gcg att ccg gca acc 403 Met Gln Ala Phe Gly Phe Ser Leu Ala Gly Ala Ala Ile Pro Ala Thr 90 95 100 att gcg tca gct gcc att ggc ctt ggt gcg cag tcg att gtt gcg gac 451 Ile Ala Ser Ala Ala Ile Gly Leu Gly Ala Gln Ser Ile Val Ala Asp 105 110 115 ttc ttg gcc gga ttt ttc atc ctg acg gaa aag caa ttc ggc gtg ggt 499 Phe Leu Ala Gly Phe Phe Ile Leu Thr Glu Lys Gln Phe Gly Val Gly 120 125 130 gac tgg gtg cgt ttt gag ggc aac ggc atc gtt gtc gaa ggc acc gtc 547 Asp Trp Val Arg Phe Glu Gly Asn Gly Ile Val Val Glu Gly Thr Val 135 140 145 att gag atc acc atg cgc gcg acc aaa att cgc acg att gca caa gag 595 Ile Glu Ile Thr Met Arg Ala Thr Lys Ile Arg Thr Ile Ala Gln Glu 150 155 160 165 acc gtg atc atc ccc aac tcc acg gcg aaa gtg tgc atc aac aat tct 643 Thr Val Ile Ile Pro Asn Ser Thr Ala Lys Val Cys Ile Asn Asn Ser 170 175 180 aat aac tgg tcg cgt gcg gtt gtc gtt att ccg atc ccc atg ttg ggt 691 Asn Asn Trp Ser Arg Ala Val Val Val Ile Pro Ile Pro Met Leu Gly 185 190 195 tct gaa aac atc aca gat gtc atc gcg cgc tct gaa gct gcg act cgt 739 Ser Glu Asn Ile Thr Asp Val Ile Ala Arg Ser Glu Ala Ala Thr Arg 200 205 210 cgc gca ctt ggc cag gag aaa atc gca ccg gaa atc ctc ggt gaa ctc 787 Arg Ala Leu Gly Gln Glu Lys Ile Ala Pro Glu Ile Leu Gly Glu Leu 215 220 225 gat gtg cac cca gcc acg gaa gtc acg ccg cca acg gtg gtc ggc atg 835 Asp Val His Pro Ala Thr Glu Val Thr Pro Pro Thr Val Val Gly Met 230 235 240 245 ccg tgg atg gtc acc atg cgt ttc ctc gtg caa gtc acc gcc ggc aat 883 Pro Trp Met Val Thr Met Arg Phe Leu Val Gln Val Thr Ala Gly Asn 250 255 260 caa tgg ctg gtc gaa cgc gcc atc cgc aca gaa atc atc agc gaa ttc 931 Gln Trp Leu Val Glu Arg Ala Ile Arg Thr Glu Ile Ile Ser Glu Phe 265 270 275 tgg gaa gaa tac ggc agc gca acc act aca tcg gga acc ctc att gat 979 Trp Glu Glu Tyr Gly Ser Ala Thr Thr Thr Ser Gly Thr Leu Ile Asp 280 285 290 tcc tta cac gtt gag cat gaa gag cca aag acc tcg ctt atc gac gcc 1027 Ser Leu His Val Glu His Glu Glu Pro Lys Thr Ser Leu Ile Asp Ala 295 300 305 tcc ccc cag gct ctt aag gaa ccg aag ccg gag gct gcg gcg acg gtt 1075 Ser Pro Gln Ala Leu Lys Glu Pro Lys Pro Glu Ala Ala Ala Thr Val 310 315 320 325 gca tcg cta gct gca tcc tct aac gac gat gca gac aat gca gac gcc 1123 Ala Ser Leu Ala Ala Ser Ser Asn Asp Asp Ala Asp Asn Ala Asp Ala 330 335 340 tcg gtg atc aat gca ggc aat cca gag aag gaa ctt gat tcc gat gtg 1171 Ser Val Ile Asn Ala Gly Asn Pro Glu Lys Glu Leu Asp Ser Asp Val 345 350 355 ctg gaa caa gaa ctc tcc agc gaa gaa ccg gaa gaa aca gca aaa cca 1219 Leu Glu Gln Glu Leu Ser Ser Glu Glu Pro Glu Glu Thr Ala Lys Pro 360 365 370 gat cac tct ctc cga ggc ttc ttc cgc act gat tac tac cca aat cgg 1267 Asp His Ser Leu Arg Gly Phe Phe Arg Thr Asp Tyr Tyr Pro Asn Arg 375 380 385 tgg cag aag atc ctg tcg ttt ggc gga cgt gtc cgc atg agc acg tcc 1315 Trp Gln Lys Ile Leu Ser Phe Gly Gly Arg Val Arg Met Ser Thr Ser 390 395 400 405 ctg ttg ttg ggt gcg ctg ctc ttg ctg tca cta ttt aag gtc atg act 1363 Leu Leu Leu Gly Ala Leu Leu Leu Leu Ser Leu Phe Lys Val Met Thr 410 415 420 gtg gaa cca agt gag aat tgg caa aac tcc agt gga tgg ctg tca cca 1411 Val Glu Pro Ser Glu Asn Trp Gln Asn Ser Ser Gly Trp Leu Ser Pro 425 430 435 agc act gcc acc tca act gcg gtg acc acc tcc gaa act tcc gcg cca 1459 Ser Thr Ala Thr Ser Thr Ala Val Thr Thr Ser Glu Thr Ser Ala Pro 440 445 450 gta agc acg cct tcg atg aca gtg ccc act acg gtg gag gag acc cca 1507 Val Ser Thr Pro Ser Met Thr Val Pro Thr Thr Val Glu Glu Thr Pro 455 460 465 acg atg gaa tct aac gtc gaa acg cag cag gaa acc tca acc cct gca 1555 Thr Met Glu Ser Asn Val Glu Thr Gln Gln Glu Thr Ser Thr Pro Ala 470 475 480 485 acc gca acg ccc cag cga gcc gac acc atc gaa ccg acc gag gaa gcc 1603 Thr Ala Thr Pro Gln Arg Ala Asp Thr Ile Glu Pro Thr Glu Glu Ala 490 495 500 acg tcg cag gag gaa acg act gcg tcg cag acg cag tct cca gca gtg 1651 Thr Ser Gln Glu Glu Thr Thr Ala Ser Gln Thr Gln Ser Pro Ala Val 505 510 515 gaa gca cca acc gcg gtc caa gag aca gtt gcg ccg acg tcc acc cct 1699 Glu Ala Pro Thr Ala Val Gln Glu Thr Val Ala Pro Thr Ser Thr Pro 520 525 530 taggacgctg attacagacg tgtcccattt 1729 <210> 340 <211> 533 <212> PRT <213> Corynebacterium glutamicum <400> 340 Met Ile Leu Gly Val Pro Ile Gln Tyr Leu Leu Tyr Ser Leu Trp Asn 1 5 10 15 Trp Ile Val Asp Thr Gly Phe Asp Val Ala Ile Ile Leu Val Leu Ala 20 25 30 Phe Leu Ile Pro Arg Ile Gly Arg Leu Ala Met Arg Ile Ile Lys Arg 35 40 45 Arg Val Glu Ser Ala Ala Asp Ala Asp Thr Thr Lys Asn Gln Leu Ala 50 55 60 Phe Ala Gly Val Gly Val Tyr Ile Ala Gln Ile Val Ala Phe Phe Met 65 70 75 80 Leu Ala Val Ser Ala Met Gln Ala Phe Gly Phe Ser Leu Ala Gly Ala 85 90 95 Ala Ile Pro Ala Thr Ile Ala Ser Ala Ala Ile Gly Leu Gly Ala Gln 100 105 110 Ser Ile Val Ala Asp Phe Leu Ala Gly Phe Phe Ile Leu Thr Glu Lys 115 120 125 Gln Phe Gly Val Gly Asp Trp Val Arg Phe Glu Gly Asn Gly Ile Val 130 135 140 Val Glu Gly Thr Val Ile Glu Ile Thr Met Arg Ala Thr Lys Ile Arg 145 150 155 160 Thr Ile Ala Gln Glu Thr Val Ile Ile Pro Asn Ser Thr Ala Lys Val 165 170 175 Cys Ile Asn Asn Ser Asn Asn Trp Ser Arg Ala Val Val Val Ile Pro 180 185 190 Ile Pro Met Leu Gly Ser Glu Asn Ile Thr Asp Val Ile Ala Arg Ser 195 200 205 Glu Ala Ala Thr Arg Arg Ala Leu Gly Gln Glu Lys Ile Ala Pro Glu 210 215 220 Ile Leu Gly Glu Leu Asp Val His Pro Ala Thr Glu Val Thr Pro Pro 225 230 235 240 Thr Val Val Gly Met Pro Trp Met Val Thr Met Arg Phe Leu Val Gln 245 250 255 Val Thr Ala Gly Asn Gln Trp Leu Val Glu Arg Ala Ile Arg Thr Glu 260 265 270 Ile Ile Ser Glu Phe Trp Glu Glu Tyr Gly Ser Ala Thr Thr Thr Ser 275 280 285 Gly Thr Leu Ile Asp Ser Leu His Val Glu His Glu Glu Pro Lys Thr 290 295 300 Ser Leu Ile Asp Ala Ser Pro Gln Ala Leu Lys Glu Pro Lys Pro Glu 305 310 315 320 Ala Ala Ala Thr Val Ala Ser Leu Ala Ala Ser Ser Asn Asp Asp Ala 325 330 335 Asp Asn Ala Asp Ala Ser Val Ile Asn Ala Gly Asn Pro Glu Lys Glu 340 345 350 Leu Asp Ser Asp Val Leu Glu Gln Glu Leu Ser Ser Glu Glu Pro Glu 355 360 365 Glu Thr Ala Lys Pro Asp His Ser Leu Arg Gly Phe Phe Arg Thr Asp 370 375 380 Tyr Tyr Pro Asn Arg Trp Gln Lys Ile Leu Ser Phe Gly Gly Arg Val 385 390 395 400 Arg Met Ser Thr Ser Leu Leu Leu Gly Ala Leu Leu Leu Leu Ser Leu 405 410 415 Phe Lys Val Met Thr Val Glu Pro Ser Glu Asn Trp Gln Asn Ser Ser 420 425 430 Gly Trp Leu Ser Pro Ser Thr Ala Thr Ser Thr Ala Val Thr Thr Ser 435 440 445 Glu Thr Ser Ala Pro Val Ser Thr Pro Ser Met Thr Val Pro Thr Thr 450 455 460 Val Glu Glu Thr Pro Thr Met Glu Ser Asn Val Glu Thr Gln Gln Glu 465 470 475 480 Thr Ser Thr Pro Ala Thr Ala Thr Pro Gln Arg Ala Asp Thr Ile Glu 485 490 495 Pro Thr Glu Glu Ala Thr Ser Gln Glu Glu Thr Thr Ala Ser Gln Thr 500 505 510 Gln Ser Pro Ala Val Glu Ala Pro Thr Ala Val Gln Glu Thr Val Ala 515 520 525 Pro Thr Ser Thr Pro 530 <210> 341 <211> 1969 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1939) <223> RXA02825 <400> 341 tggcctgccc ctgaaacttt tacggctttc agagcgcagg gcatcatttt cttgtgtcgc 60 caacacttga gaaaaattgc ggaaaaggac actgctgttc atg aaa ctt gca cct 115 Met Lys Leu Ala Pro 1 5 cgt atg cgg atg agg agc ccc aaa act ttc gcg gcc ctc gcc tca ctt 163 Arg Met Arg Met Arg Ser Pro Lys Thr Phe Ala Ala Leu Ala Ser Leu 10 15 20 gct tta gtc ata ggt ctc ggc cag gta ccg atc gcc caa gct caa acc 211 Ala Leu Val Ile Gly Leu Gly Gln Val Pro Ile Ala Gln Ala Gln Thr 25 30 35 gag tat cga acc gcc tcc gac ggt tcc ctg aac tgg gga ttt agg caa 259 Glu Tyr Arg Thr Ala Ser Asp Gly Ser Leu Asn Trp Gly Phe Arg Gln 40 45 50 tcg ttc cgc aat tac atc caa acc ggc gtg gcc aaa ggt tcc atc acg 307 Ser Phe Arg Asn Tyr Ile Gln Thr Gly Val Ala Lys Gly Ser Ile Thr 55 60 65 ctt ggc gac ggc gca tcc gac aac ggt ggc aac ttc gca ttc acc cca 355 Leu Gly Asp Gly Ala Ser Asp Asn Gly Gly Asn Phe Ala Phe Thr Pro 70 75 80 85 cgc acc aac ggc acc acc gtg acc agc gat tcc caa ggc acc gtg gaa 403 Arg Thr Asn Gly Thr Thr Val Thr Ser Asp Ser Gln Gly Thr Val Glu 90 95 100 ttc aac ggc tcc gtg cac ttc ctc gga cac cag gca gag gac aaa tgg 451 Phe Asn Gly Ser Val His Phe Leu Gly His Gln Ala Glu Asp Lys Trp 105 110 115 atc ctg gac acc acc atg tct gac atc aaa atg gtg ttc aac gga tcc 499 Ile Leu Asp Thr Thr Met Ser Asp Ile Lys Met Val Phe Asn Gly Ser 120 125 130 tcc gcg cag cta gtt gtg gat ttg gtt gcc cgc gaa ttc aag ggc acc 547 Ser Ala Gln Leu Val Val Asp Leu Val Ala Arg Glu Phe Lys Gly Thr 135 140 145 acc tac gat gac atc ggc gaa tac atc atc tcc gac gac atc gtg ctt 595 Thr Tyr Asp Asp Ile Gly Glu Tyr Ile Ile Ser Asp Asp Ile Val Leu 150 155 160 165 gcc gac gtc tcc ctc aac tcc gcc gcc gac ttc tcc caa gat tcc atc 643 Ala Asp Val Ser Leu Asn Ser Ala Ala Asp Phe Ser Gln Asp Ser Ile 170 175 180 gac ctg tcc ggc acc acc gac ctc acc gca gct ggc gcc caa gct ttc 691 Asp Leu Ser Gly Thr Thr Asp Leu Thr Ala Ala Gly Ala Gln Ala Phe 185 190 195 gga gga ttc tac gaa acc ggc gaa gcc ctc gac ccg acc ggc ggc agc 739 Gly Gly Phe Tyr Glu Thr Gly Glu Ala Leu Asp Pro Thr Gly Gly Ser 200 205 210 ctg acc att tcc tcc acc acc acc gcg cca tcg acc agc acg acc tcc 787 Leu Thr Ile Ser Ser Thr Thr Thr Ala Pro Ser Thr Ser Thr Thr Ser 215 220 225 acc tct gcc tca act tcc ggt gga acc gcc gac tgt tcc tcc ggc gca 835 Thr Ser Ala Ser Thr Ser Gly Gly Thr Ala Asp Cys Ser Ser Gly Ala 230 235 240 245 ttg ggt gtt gtc acc acc gga acc aac gac ggc atg ctg ggc acc atc 883 Leu Gly Val Val Thr Thr Gly Thr Asn Asp Gly Met Leu Gly Thr Ile 250 255 260 cag gaa gta aac aac acc ttc gcg att tgg aac aac ctc atc gtc aac 931 Gln Glu Val Asn Asn Thr Phe Ala Ile Trp Asn Asn Leu Ile Val Asn 265 270 275 acc gag cgc atg ttc tgc aac att gat acc ctc aag gcg cgc ttc gac 979 Thr Glu Arg Met Phe Cys Asn Ile Asp Thr Leu Lys Ala Arg Phe Asp 280 285 290 acg gat gat tcc agc gat tca gcg acc tct gcg act tct ggg act act 1027 Thr Asp Asp Ser Ser Asp Ser Ala Thr Ser Ala Thr Ser Gly Thr Thr 295 300 305 gcg tcc acc ggc acc acc gct gca act acc gcg gga acc acg ggt acc 1075 Ala Ser Thr Gly Thr Thr Ala Ala Thr Thr Ala Gly Thr Thr Gly Thr 310 315 320 325 act gga act gcc agc acc gct tcc gga act tcc gga act tcc gga acc 1123 Thr Gly Thr Ala Ser Thr Ala Ser Gly Thr Ser Gly Thr Ser Gly Thr 330 335 340 tcc ggc acc gca gca act gtc gct ggc acc acc cca act gac aat ggc 1171 Ser Gly Thr Ala Ala Thr Val Ala Gly Thr Thr Pro Thr Asp Asn Gly 345 350 355 gtt tgc acc gct tcc gga tct ttg ggc gtg acc caa gca tct gcg cag 1219 Val Cys Thr Ala Ser Gly Ser Leu Gly Val Thr Gln Ala Ser Ala Gln 360 365 370 tgg ggt gtg aag gcg tcc ttc cag aac tac att cgc gga tcg atc gcc 1267 Trp Gly Val Lys Ala Ser Phe Gln Asn Tyr Ile Arg Gly Ser Ile Ala 375 380 385 aac ggt agc tgg act ctc aac ggc gtt ggt ttt gat aat cag cag ttc 1315 Asn Gly Ser Trp Thr Leu Asn Gly Val Gly Phe Asp Asn Gln Gln Phe 390 395 400 405 caa ttc tct gga aat tcc gga gca gtc gac gcg gaa aac aag acc ggc 1363 Gln Phe Ser Gly Asn Ser Gly Ala Val Asp Ala Glu Asn Lys Thr Gly 410 415 420 agc atc aat ttc cct ggt tcc atc cac ttc acg ggt cac ggc gga atc 1411 Ser Ile Asn Phe Pro Gly Ser Ile His Phe Thr Gly His Gly Gly Ile 425 430 435 ttg gac atg cag atc gca aac att gag atc agc ttc aac ggc aac tcc 1459 Leu Asp Met Gln Ile Ala Asn Ile Glu Ile Ser Phe Asn Gly Asn Ser 440 445 450 ggc gag ctg att gcg gat gtc gtt tcc tct gac atg gat gga aat tcc 1507 Gly Glu Leu Ile Ala Asp Val Val Ser Ser Asp Met Asp Gly Asn Ser 455 460 465 acc aac tac ggt cgc act gtc gtg ggc acc ctg aac ttc tct gcg ttg 1555 Thr Asn Tyr Gly Arg Thr Val Val Gly Thr Leu Asn Phe Ser Ala Leu 470 475 480 485 aat gtt tct gca acg gaa gct tcc ggt tcc gct tcg gtg tcc ctg tca 1603 Asn Val Ser Ala Thr Glu Ala Ser Gly Ser Ala Ser Val Ser Leu Ser 490 495 500 cag tcg ggt tcg cag gcg ttc gct gat ttc tac acc cca ggc acc cag 1651 Gln Ser Gly Ser Gln Ala Phe Ala Asp Phe Tyr Thr Pro Gly Thr Gln 505 510 515 ttg gat ccg atc agt ttc agc gca act ttg ggc ggc gac gcc agc tgc 1699 Leu Asp Pro Ile Ser Phe Ser Ala Thr Leu Gly Gly Asp Ala Ser Cys 520 525 530 gcc acc gga tcc acc tcg acc aca ggc gct gct gcc acc gcg aac act 1747 Ala Thr Gly Ser Thr Ser Thr Thr Gly Ala Ala Ala Thr Ala Asn Thr 535 540 545 gac aac acc gaa ggt gtt gcc ggc gag gaa tcc acc acc ccc gct aac 1795 Asp Asn Thr Glu Gly Val Ala Gly Glu Glu Ser Thr Thr Pro Ala Asn 550 555 560 565 caa aac agc cag ttc caa atc cgc cag gcc gct gca gat tcc acc gga 1843 Gln Asn Ser Gln Phe Gln Ile Arg Gln Ala Ala Ala Asp Ser Thr Gly 570 575 580 ctg gat acc acc acc aca atg ttg ctc atc ctc gcg gcg ttc gtt gtc 1891 Leu Asp Thr Thr Thr Thr Met Leu Leu Ile Leu Ala Ala Phe Val Val 585 590 595 gca ggt ggc tcc atg act cgc ttc acc gtc ggc aac ccg act gga aaa 1939 Ala Gly Gly Ser Met Thr Arg Phe Thr Val Gly Asn Pro Thr Gly Lys 600 605 610 taaggcttca catgaataac gcttttcgac 1969 <210> 342 <211> 613 <212> PRT <213> Corynebacterium glutamicum <400> 342 Met Lys Leu Ala Pro Arg Met Arg Met Arg Ser Pro Lys Thr Phe Ala 1 5 10 15 Ala Leu Ala Ser Leu Ala Leu Val Ile Gly Leu Gly Gln Val Pro Ile 20 25 30 Ala Gln Ala Gln Thr Glu Tyr Arg Thr Ala Ser Asp Gly Ser Leu Asn 35 40 45 Trp Gly Phe Arg Gln Ser Phe Arg Asn Tyr Ile Gln Thr Gly Val Ala 50 55 60 Lys Gly Ser Ile Thr Leu Gly Asp Gly Ala Ser Asp Asn Gly Gly Asn 65 70 75 80 Phe Ala Phe Thr Pro Arg Thr Asn Gly Thr Thr Val Thr Ser Asp Ser 85 90 95 Gln Gly Thr Val Glu Phe Asn Gly Ser Val His Phe Leu Gly His Gln 100 105 110 Ala Glu Asp Lys Trp Ile Leu Asp Thr Thr Met Ser Asp Ile Lys Met 115 120 125 Val Phe Asn Gly Ser Ser Ala Gln Leu Val Val Asp Leu Val Ala Arg 130 135 140 Glu Phe Lys Gly Thr Thr Tyr Asp Asp Ile Gly Glu Tyr Ile Ile Ser 145 150 155 160 Asp Asp Ile Val Leu Ala Asp Val Ser Leu Asn Ser Ala Ala Asp Phe 165 170 175 Ser Gln Asp Ser Ile Asp Leu Ser Gly Thr Thr Asp Leu Thr Ala Ala 180 185 190 Gly Ala Gln Ala Phe Gly Gly Phe Tyr Glu Thr Gly Glu Ala Leu Asp 195 200 205 Pro Thr Gly Gly Ser Leu Thr Ile Ser Ser Thr Thr Thr Ala Pro Ser 210 215 220 Thr Ser Thr Thr Ser Thr Ser Ala Ser Thr Ser Gly Gly Thr Ala Asp 225 230 235 240 Cys Ser Ser Gly Ala Leu Gly Val Val Thr Thr Gly Thr Asn Asp Gly 245 250 255 Met Leu Gly Thr Ile Gln Glu Val Asn Asn Thr Phe Ala Ile Trp Asn 260 265 270 Asn Leu Ile Val Asn Thr Glu Arg Met Phe Cys Asn Ile Asp Thr Leu 275 280 285 Lys Ala Arg Phe Asp Thr Asp Asp Ser Ser Asp Ser Ala Thr Ser Ala 290 295 300 Thr Ser Gly Thr Thr Ala Ser Thr Gly Thr Thr Ala Ala Thr Thr Ala 305 310 315 320 Gly Thr Thr Gly Thr Thr Gly Thr Ala Ser Thr Ala Ser Gly Thr Ser 325 330 335 Gly Thr Ser Gly Thr Ser Gly Thr Ala Ala Thr Val Ala Gly Thr Thr 340 345 350 Pro Thr Asp Asn Gly Val Cys Thr Ala Ser Gly Ser Leu Gly Val Thr 355 360 365 Gln Ala Ser Ala Gln Trp Gly Val Lys Ala Ser Phe Gln Asn Tyr Ile 370 375 380 Arg Gly Ser Ile Ala Asn Gly Ser Trp Thr Leu Asn Gly Val Gly Phe 385 390 395 400 Asp Asn Gln Gln Phe Gln Phe Ser Gly Asn Ser Gly Ala Val Asp Ala 405 410 415 Glu Asn Lys Thr Gly Ser Ile Asn Phe Pro Gly Ser Ile His Phe Thr 420 425 430 Gly His Gly Gly Ile Leu Asp Met Gln Ile Ala Asn Ile Glu Ile Ser 435 440 445 Phe Asn Gly Asn Ser Gly Glu Leu Ile Ala Asp Val Val Ser Ser Asp 450 455 460 Met Asp Gly Asn Ser Thr Asn Tyr Gly Arg Thr Val Val Gly Thr Leu 465 470 475 480 Asn Phe Ser Ala Leu Asn Val Ser Ala Thr Glu Ala Ser Gly Ser Ala 485 490 495 Ser Val Ser Leu Ser Gln Ser Gly Ser Gln Ala Phe Ala Asp Phe Tyr 500 505 510 Thr Pro Gly Thr Gln Leu Asp Pro Ile Ser Phe Ser Ala Thr Leu Gly 515 520 525 Gly Asp Ala Ser Cys Ala Thr Gly Ser Thr Ser Thr Thr Gly Ala Ala 530 535 540 Ala Thr Ala Asn Thr Asp Asn Thr Glu Gly Val Ala Gly Glu Glu Ser 545 550 555 560 Thr Thr Pro Ala Asn Gln Asn Ser Gln Phe Gln Ile Arg Gln Ala Ala 565 570 575 Ala Asp Ser Thr Gly Leu Asp Thr Thr Thr Thr Met Leu Leu Ile Leu 580 585 590 Ala Ala Phe Val Val Ala Gly Gly Ser Met Thr Arg Phe Thr Val Gly 595 600 605 Asn Pro Thr Gly Lys 610 <210> 343 <211> 739 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(709) <223> RXA02951 <400> 343 gataatgagt cagaaaatga aggtagcact acttgctgga ttaattttca aggttttctt 60 tcagaaatta atccatagcc gatatttaag gtgagaacac atg agc tcc acg ctc 115 Met Ser Ser Thr Leu 1 5 gca cga aaa gct tca ggc gac ggt tcc gaa aag aag aag cct ggc ttg 163 Ala Arg Lys Ala Ser Gly Asp Gly Ser Glu Lys Lys Lys Pro Gly Leu 10 15 20 ttt aga cgt gcg ctt cgt ttc ctc acc cac cca cct cac aaa cag gta 211 Phe Arg Arg Ala Leu Arg Phe Leu Thr His Pro Pro His Lys Gln Val 25 30 35 gac aac agc ctt gcg gat atc cgt gaa gga tta ggc ctc ggg gtg gac 259 Asp Asn Ser Leu Ala Asp Ile Arg Glu Gly Leu Gly Leu Gly Val Asp 40 45 50 gat tcc cac gaa gga tcc aaa ccc agc aac gat cat tct ttg ctg cat 307 Asp Ser His Glu Gly Ser Lys Pro Ser Asn Asp His Ser Leu Leu His 55 60 65 gaa aag cct gaa att tcc gtc atg ccg acc gaa tca atg gca cgg ctg 355 Glu Lys Pro Glu Ile Ser Val Met Pro Thr Glu Ser Met Ala Arg Leu 70 75 80 85 atc ttt tat gcg cct gat atg gat ggg caa aca gac ccc ggt gaa gta 403 Ile Phe Tyr Ala Pro Asp Met Asp Gly Gln Thr Asp Pro Gly Glu Val 90 95 100 gtg tgg att tgg gca cca gcc gat ggc ccc cag caa cca ccc cgt aaa 451 Val Trp Ile Trp Ala Pro Ala Asp Gly Pro Gln Gln Pro Pro Arg Lys 105 110 115 cgt gcc atc gtt gtt gtt gga aga aac cga aac gcc att tta ggt ctg 499 Arg Ala Ile Val Val Val Gly Arg Asn Arg Asn Ala Ile Leu Gly Leu 120 125 130 ctc att tcc tgc aac ccc gag cac cgc act gat gaa gac tgg atc gac 547 Leu Ile Ser Cys Asn Pro Glu His Arg Thr Asp Glu Asp Trp Ile Asp 135 140 145 att gga tct ggc agc tgg gac cct cga ggt cgc caa agt tgg gta cga 595 Ile Gly Ser Gly Ser Trp Asp Pro Arg Gly Arg Gln Ser Trp Val Arg 150 155 160 165 ctc gac cgc gtt ctg gag gta ccc gaa ttg ggt atc cgg cgc caa gga 643 Leu Asp Arg Val Leu Glu Val Pro Glu Leu Gly Ile Arg Arg Gln Gly 170 175 180 aca gtc gtc ccc ccg ggg cgc ttt gag cgt atc gcc aac cgc ctc cgc 691 Thr Val Val Pro Pro Gly Arg Phe Glu Arg Ile Ala Asn Arg Leu Arg 185 190 195 aac gat ttc aac tgg gtc taacatttat ttggtaattg ggcaacatca 739 Asn Asp Phe Asn Trp Val 200 <210> 344 <211> 203 <212> PRT <213> Corynebacterium glutamicum <400> 344 Met Ser Ser Thr Leu Ala Arg Lys Ala Ser Gly Asp Gly Ser Glu Lys 1 5 10 15 Lys Lys Pro Gly Leu Phe Arg Arg Ala Leu Arg Phe Leu Thr His Pro 20 25 30 Pro His Lys Gln Val Asp Asn Ser Leu Ala Asp Ile Arg Glu Gly Leu 35 40 45 Gly Leu Gly Val Asp Asp Ser His Glu Gly Ser Lys Pro Ser Asn Asp 50 55 60 His Ser Leu Leu His Glu Lys Pro Glu Ile Ser Val Met Pro Thr Glu 65 70 75 80 Ser Met Ala Arg Leu Ile Phe Tyr Ala Pro Asp Met Asp Gly Gln Thr 85 90 95 Asp Pro Gly Glu Val Val Trp Ile Trp Ala Pro Ala Asp Gly Pro Gln 100 105 110 Gln Pro Pro Arg Lys Arg Ala Ile Val Val Val Gly Arg Asn Arg Asn 115 120 125 Ala Ile Leu Gly Leu Leu Ile Ser Cys Asn Pro Glu His Arg Thr Asp 130 135 140 Glu Asp Trp Ile Asp Ile Gly Ser Gly Ser Trp Asp Pro Arg Gly Arg 145 150 155 160 Gln Ser Trp Val Arg Leu Asp Arg Val Leu Glu Val Pro Glu Leu Gly 165 170 175 Ile Arg Arg Gln Gly Thr Val Val Pro Pro Gly Arg Phe Glu Arg Ile 180 185 190 Ala Asn Arg Leu Arg Asn Asp Phe Asn Trp Val 195 200 <210> 345 <211> 742 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(712) <223> RXA03010 <400> 345 ttatattaat caaacaggaa aatgtcagag aagaaggcat atctcaagga aacttggcag 60 ctttagagtt tcgatcaatt attcacgtgc ggagtagctg atg tca caa gga ttt 115 Met Ser Gln Gly Phe 1 5 acc caa cca ccc ggg gga acg ttt ggt tct tcc tct ggc gga ttt tca 163 Thr Gln Pro Pro Gly Gly Thr Phe Gly Ser Ser Ser Gly Gly Phe Ser 10 15 20 ggc ggg caa tca ggt ttc ggt gga ggc tcc caa aac agt ggt ttt ggt 211 Gly Gly Gln Ser Gly Phe Gly Gly Gly Ser Gln Asn Ser Gly Phe Gly 25 30 35 ggc tct tca ggc ggt ttc tct ggg ggt tca tcg aat ggc tcg ttc ggc 259 Gly Ser Ser Gly Gly Phe Ser Gly Gly Ser Ser Asn Gly Ser Phe Gly 40 45 50 ggt tca act ggc ggg ttt acc ccg gcc gga gca acg tca aac cca tcg 307 Gly Ser Thr Gly Gly Phe Thr Pro Ala Gly Ala Thr Ser Asn Pro Ser 55 60 65 ggc ttt tcg acg cca aag gtt gca gaa agc cca gcg ccg ggg cgc tca 355 Gly Phe Ser Thr Pro Lys Val Ala Glu Ser Pro Ala Pro Gly Arg Ser 70 75 80 85 tcg ggg cga aaa aga gct ggt ggg cgc ctt caa tcg gca ccc act gaa 403 Ser Gly Arg Lys Arg Ala Gly Gly Arg Leu Gln Ser Ala Pro Thr Glu 90 95 100 tgg att ctt ccg ggc cta gtt tta ggg ctg atc agc ctg gga ctc aat 451 Trp Ile Leu Pro Gly Leu Val Leu Gly Leu Ile Ser Leu Gly Leu Asn 105 110 115 gcg tgg att acc ttc ggt gcg cca gtg gcc acc gat aat ctt ttt ctc 499 Ala Trp Ile Thr Phe Gly Ala Pro Val Ala Thr Asp Asn Leu Phe Leu 120 125 130 atc gtt gct gga att gcg tgg gtg ttg gca gga att ttg agc gtg ctg 547 Ile Val Ala Gly Ile Ala Trp Val Leu Ala Gly Ile Leu Ser Val Leu 135 140 145 tcc atc ggc aag tac atg tca gca gta aat gag cga aag tcg aca ggc 595 Ser Ile Gly Lys Tyr Met Ser Ala Val Asn Glu Arg Lys Ser Thr Gly 150 155 160 165 ttt tat aca gaa gtg ccg tgg aag aaa gcg ctc ttt act gcg aca gcc 643 Phe Tyr Thr Glu Val Pro Trp Lys Lys Ala Leu Phe Thr Ala Thr Ala 170 175 180 gtc cta ttg gtg ttt gct gtt gtg tgg tcg gcc ttg gat att gcc ctg 691 Val Leu Leu Val Phe Ala Val Val Trp Ser Ala Leu Asp Ile Ala Leu 185 190 195 tgg gta gga aag cag tca tgg tgaacacgtt gaactctaaa accgtgaatg 742 Trp Val Gly Lys Gln Ser Trp 200 <210> 346 <211> 204 <212> PRT <213> Corynebacterium glutamicum <400> 346 Met Ser Gln Gly Phe Thr Gln Pro Pro Gly Gly Thr Phe Gly Ser Ser 1 5 10 15 Ser Gly Gly Phe Ser Gly Gly Gln Ser Gly Phe Gly Gly Gly Ser Gln 20 25 30 Asn Ser Gly Phe Gly Gly Ser Ser Gly Gly Phe Ser Gly Gly Ser Ser 35 40 45 Asn Gly Ser Phe Gly Gly Ser Thr Gly Gly Phe Thr Pro Ala Gly Ala 50 55 60 Thr Ser Asn Pro Ser Gly Phe Ser Thr Pro Lys Val Ala Glu Ser Pro 65 70 75 80 Ala Pro Gly Arg Ser Ser Gly Arg Lys Arg Ala Gly Gly Arg Leu Gln 85 90 95 Ser Ala Pro Thr Glu Trp Ile Leu Pro Gly Leu Val Leu Gly Leu Ile 100 105 110 Ser Leu Gly Leu Asn Ala Trp Ile Thr Phe Gly Ala Pro Val Ala Thr 115 120 125 Asp Asn Leu Phe Leu Ile Val Ala Gly Ile Ala Trp Val Leu Ala Gly 130 135 140 Ile Leu Ser Val Leu Ser Ile Gly Lys Tyr Met Ser Ala Val Asn Glu 145 150 155 160 Arg Lys Ser Thr Gly Phe Tyr Thr Glu Val Pro Trp Lys Lys Ala Leu 165 170 175 Phe Thr Ala Thr Ala Val Leu Leu Val Phe Ala Val Val Trp Ser Ala 180 185 190 Leu Asp Ile Ala Leu Trp Val Gly Lys Gln Ser Trp 195 200 <210> 347 <211> 1060 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1030) <223> RXA03029 <400> 347 aacacgcctg aggaacgccg tcccatcgcg gaggccgtga gcatgccgca cgaagaggtc 60 cgcgatttca tttacgcccg ccaaaactac ttcgatgccc ttg acc gcc gcg ccg 115 Leu Thr Ala Ala Pro 1 5 aag cca tgc gcc gcg caa ctg ggc tgg cag ccg tac gat tcc cgc gcc 163 Lys Pro Cys Ala Ala Gln Leu Gly Trp Gln Pro Tyr Asp Ser Arg Ala 10 15 20 atg gaa gat tcg atc gcc cgc cgc ctg caa atg gat cac gat gtc acc 211 Met Glu Asp Ser Ile Ala Arg Arg Leu Gln Met Asp His Asp Val Thr 25 30 35 atc acc tcc tcc aaa gag gaa tcc ggc acg ctg cac cac ttc gac ccc 259 Ile Thr Ser Ser Lys Glu Glu Ser Gly Thr Leu His His Phe Asp Pro 40 45 50 gag acg cgt ctg ctg aca atc cac gca cgc ctc aac ccc ggg caa cgc 307 Glu Thr Arg Leu Leu Thr Ile His Ala Arg Leu Asn Pro Gly Gln Arg 55 60 65 gcc ttc cgc atg gcc acc gaa ctc ggc tac cta gaa gcc aac gac ctc 355 Ala Phe Arg Met Ala Thr Glu Leu Gly Tyr Leu Glu Ala Asn Asp Leu 70 75 80 85 atc gaa ggt atc gtt gac gac ggc atc tgg tcc acc ccc gaa gcc cgc 403 Ile Glu Gly Ile Val Asp Asp Gly Ile Trp Ser Thr Pro Glu Ala Arg 90 95 100 acc cta gcc atc cgc ggt gtg gcc tcc tac ttc gcc gcc gcc gtg atg 451 Thr Leu Ala Ile Arg Gly Val Ala Ser Tyr Phe Ala Ala Ala Val Met 105 110 115 ctg ccc tac aaa atc ttc cac tcc gag gcc gaa aaa tcc ggc tac gac 499 Leu Pro Tyr Lys Ile Phe His Ser Glu Ala Glu Lys Ser Gly Tyr Asp 120 125 130 atc gag tac cta ggc caa ctc ttt ggc gtg ggc tat gag aca acc gcc 547 Ile Glu Tyr Leu Gly Gln Leu Phe Gly Val Gly Tyr Glu Thr Thr Ala 135 140 145 cac cgc ttg tcc acc ctg cag cgc ccc aac ctg cgc ggc atc ccc ttt 595 His Arg Leu Ser Thr Leu Gln Arg Pro Asn Leu Arg Gly Ile Pro Phe 150 155 160 165 acc ttc gtg cgc gtc gac cgc gcc ggc aac atg tcc aaa cgc caa tcc 643 Thr Phe Val Arg Val Asp Arg Ala Gly Asn Met Ser Lys Arg Gln Ser 170 175 180 gcc acc ggc ttc cac ttc acc cac tac ggc ggc acc tgc ccc ctg tgg 691 Ala Thr Gly Phe His Phe Thr His Tyr Gly Gly Thr Cys Pro Leu Trp 185 190 195 aac gtg ttt gaa acc ttc acc aac ccc ggc caa gtg ctc cgc caa ttc 739 Asn Val Phe Glu Thr Phe Thr Asn Pro Gly Gln Val Leu Arg Gln Phe 200 205 210 gcg caa atg ccc gac gga cgc aac tac ctg tgg atc tca cgc acc gtg 787 Ala Gln Met Pro Asp Gly Arg Asn Tyr Leu Trp Ile Ser Arg Thr Val 215 220 225 cga cac cac gaa gcc cgg ttc ggc gaa gta gac aaa atg ttc gcc atc 835 Arg His His Glu Ala Arg Phe Gly Glu Val Asp Lys Met Phe Ala Ile 230 235 240 245 ggc ctg ggc tgc gaa gcg cgc cac gcc gac cgc act gtg tac tcc cgc 883 Gly Leu Gly Cys Glu Ala Arg His Ala Asp Arg Thr Val Tyr Ser Arg 250 255 260 ggt ttc aac ctc cag gac ctc tcc acc gcc acc ccc atc ggg tcc ggc 931 Gly Phe Asn Leu Gln Asp Leu Ser Thr Ala Thr Pro Ile Gly Ser Gly 265 270 275 tgc cga gtg tgc acc cgc gag aac tgc gcg cag cgc gca ttc cca tcc 979 Cys Arg Val Cys Thr Arg Glu Asn Cys Ala Gln Arg Ala Phe Pro Ser 280 285 290 gtc cac ggc cgc atc aac atc gac gcg cac gaa tcc act atc gcg ccg 1027 Val His Gly Arg Ile Asn Ile Asp Ala His Glu Ser Thr Ile Ala Pro 295 300 305 tac taagaaaagg agcttgcttt acgacgcacc 1060 Tyr 310 <210> 348 <211> 310 <212> PRT <213> Corynebacterium glutamicum <400> 348 Leu Thr Ala Ala Pro Lys Pro Cys Ala Ala Gln Leu Gly Trp Gln Pro 1 5 10 15 Tyr Asp Ser Arg Ala Met Glu Asp Ser Ile Ala Arg Arg Leu Gln Met 20 25 30 Asp His Asp Val Thr Ile Thr Ser Ser Lys Glu Glu Ser Gly Thr Leu 35 40 45 His His Phe Asp Pro Glu Thr Arg Leu Leu Thr Ile His Ala Arg Leu 50 55 60 Asn Pro Gly Gln Arg Ala Phe Arg Met Ala Thr Glu Leu Gly Tyr Leu 65 70 75 80 Glu Ala Asn Asp Leu Ile Glu Gly Ile Val Asp Asp Gly Ile Trp Ser 85 90 95 Thr Pro Glu Ala Arg Thr Leu Ala Ile Arg Gly Val Ala Ser Tyr Phe 100 105 110 Ala Ala Ala Val Met Leu Pro Tyr Lys Ile Phe His Ser Glu Ala Glu 115 120 125 Lys Ser Gly Tyr Asp Ile Glu Tyr Leu Gly Gln Leu Phe Gly Val Gly 130 135 140 Tyr Glu Thr Thr Ala His Arg Leu Ser Thr Leu Gln Arg Pro Asn Leu 145 150 155 160 Arg Gly Ile Pro Phe Thr Phe Val Arg Val Asp Arg Ala Gly Asn Met 165 170 175 Ser Lys Arg Gln Ser Ala Thr Gly Phe His Phe Thr His Tyr Gly Gly 180 185 190 Thr Cys Pro Leu Trp Asn Val Phe Glu Thr Phe Thr Asn Pro Gly Gln 195 200 205 Val Leu Arg Gln Phe Ala Gln Met Pro Asp Gly Arg Asn Tyr Leu Trp 210 215 220 Ile Ser Arg Thr Val Arg His His Glu Ala Arg Phe Gly Glu Val Asp 225 230 235 240 Lys Met Phe Ala Ile Gly Leu Gly Cys Glu Ala Arg His Ala Asp Arg 245 250 255 Thr Val Tyr Ser Arg Gly Phe Asn Leu Gln Asp Leu Ser Thr Ala Thr 260 265 270 Pro Ile Gly Ser Gly Cys Arg Val Cys Thr Arg Glu Asn Cys Ala Gln 275 280 285 Arg Ala Phe Pro Ser Val His Gly Arg Ile Asn Ile Asp Ala His Glu 290 295 300 Ser Thr Ile Ala Pro Tyr 305 310 <210> 349 <211> 2032 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2002) <223> RXA03053 <400> 349 tattttgtcg tttttccaca atgaggatgc caaggatgaa ttcggtgctt tctggggcgt 60 caaccgcatt ccacgcaatc tgcctgaggg tgtctcagct gtg ctt ttt gag caa 115 Val Leu Phe Glu Gln 1 5 gtg gag cgg atg aag cag tca tgg att gat gac aat ctg aaa aat act 163 Val Glu Arg Met Lys Gln Ser Trp Ile Asp Asp Asn Leu Lys Asn Thr 10 15 20 gac cga cta gct aag aca gaa gaa tca gac ttg gct gat tct tcc act 211 Asp Arg Leu Ala Lys Thr Glu Glu Ser Asp Leu Ala Asp Ser Ser Thr 25 30 35 aag tcc aac cgc cgc aag act gtt aag cgt gga ctt gat ctt gat gag 259 Lys Ser Asn Arg Arg Lys Thr Val Lys Arg Gly Leu Asp Leu Asp Glu 40 45 50 gtg atc gcc gag ctt gat gat ggt gca tca tat ttg act gtg cac aac 307 Val Ile Ala Glu Leu Asp Asp Gly Ala Ser Tyr Leu Thr Val His Asn 55 60 65 cgt ctg ctg ctg cgt gga cca aac ctt gag atc ttg gat tcg act gtt 355 Arg Leu Leu Leu Arg Gly Pro Asn Leu Glu Ile Leu Asp Ser Thr Val 70 75 80 85 gag aaa att cga cgc agt ttt atc gag cac tta tcg cga atg gat att 403 Glu Lys Ile Arg Arg Ser Phe Ile Glu His Leu Ser Arg Met Asp Ile 90 95 100 gct gca cac cac ggt gag caa cgt caa gaa ctg tca cag att ttt ggc 451 Ala Ala His His Gly Glu Gln Arg Gln Glu Leu Ser Gln Ile Phe Gly 105 110 115 aaa aat agc aaa aag cga ggt aaa gga ttc cac ttc acc tcg act gag 499 Lys Asn Ser Lys Lys Arg Gly Lys Gly Phe His Phe Thr Ser Thr Glu 120 125 130 ttt gcc ggt tct tat tct ttg gtc acc aat ggt ctt aac gat gtt gct 547 Phe Ala Gly Ser Tyr Ser Leu Val Thr Asn Gly Leu Asn Asp Val Ala 135 140 145 ggc gaa tac gtc ggt gtc atg cgt ggc gat gtc aac aac tcc gct gtg 595 Gly Glu Tyr Val Gly Val Met Arg Gly Asp Val Asn Asn Ser Ala Val 150 155 160 165 ctt ttt gat gtg gat cgc tgg tcg gga cat gtc gta tgc gca gat agc 643 Leu Phe Asp Val Asp Arg Trp Ser Gly His Val Val Cys Ala Asp Ser 170 175 180 tcg att aat aca tca cca cta ctt aag cgt ccc cgt gtc gtt gac atg 691 Ser Ile Asn Thr Ser Pro Leu Leu Lys Arg Pro Arg Val Val Asp Met 185 190 195 tgg ggg tcg aag att tct cag gca gcg cta ctg aat aac cgt cgc gta 739 Trp Gly Ser Lys Ile Ser Gln Ala Ala Leu Leu Asn Asn Arg Arg Val 200 205 210 gtg cac ctg gtg ctc aat ggt gcc aag ctc gat gaa atg gga cca aag 787 Val His Leu Val Leu Asn Gly Ala Lys Leu Asp Glu Met Gly Pro Lys 215 220 225 cta gaa tcc atg acc gct cat gtg gat atg act agc gga gat ctc aac 835 Leu Glu Ser Met Thr Ala His Val Asp Met Thr Ser Gly Asp Leu Asn 230 235 240 245 atg ttc gag ctg ttt ggt aag caa gaa gat gag ctg tcg ctg tat tcc 883 Met Phe Glu Leu Phe Gly Lys Gln Glu Asp Glu Leu Ser Leu Tyr Ser 250 255 260 aca cac atg gac aaa atc gtg ttt atg acc gag cag gca ttg ggc gat 931 Thr His Met Asp Lys Ile Val Phe Met Thr Glu Gln Ala Leu Gly Asp 265 270 275 aag acc tct gag ctg gcg cta ttg cgc gga aag ctc aaa gaa att att 979 Lys Thr Ser Glu Leu Ala Leu Leu Arg Gly Lys Leu Lys Glu Ile Ile 280 285 290 aca gcc ttt tat gtg gat atg aaa atg tgg gct ctt aat gcc ggt gaa 1027 Thr Ala Phe Tyr Val Asp Met Lys Met Trp Ala Leu Asn Ala Gly Glu 295 300 305 aac cgt gac aag ctg cgt ctt gtt ggt gtg cct cat gag cag atc ccg 1075 Asn Arg Asp Lys Leu Arg Leu Val Gly Val Pro His Glu Gln Ile Pro 310 315 320 325 ttg ctc tct gtc ttc gtg tcc tat ttg gat caa gaa tat gag cgc cag 1123 Leu Leu Ser Val Phe Val Ser Tyr Leu Asp Gln Glu Tyr Glu Arg Gln 330 335 340 aaa tat gag gga acc aaa gac cct gaa atg ttt cgt gcc att tct gtg 1171 Lys Tyr Glu Gly Thr Lys Asp Pro Glu Met Phe Arg Ala Ile Ser Val 345 350 355 ctg cga ctg acc tat aag gat ttg ctc gat act cat ggc gat ctg ttt 1219 Leu Arg Leu Thr Tyr Lys Asp Leu Leu Asp Thr His Gly Asp Leu Phe 360 365 370 aat cag cac acg gca gat ggc att gat tct gtg aac tct gca cgc cgc 1267 Asn Gln His Thr Ala Asp Gly Ile Asp Ser Val Asn Ser Ala Arg Arg 375 380 385 gtg atc tat gat ttt tct gga gtg ctg cga cgt ggc gca ggt gtc gcg 1315 Val Ile Tyr Asp Phe Ser Gly Val Leu Arg Arg Gly Ala Gly Val Ala 390 395 400 405 atg gca cag ctg gtt aac gtg att ggt ttt gct gtg gag acg ctt ggt 1363 Met Ala Gln Leu Val Asn Val Ile Gly Phe Ala Val Glu Thr Leu Gly 410 415 420 caa ggc gat gtg gtc atc att cac ggt gct gat ggc att gtc gat gtt 1411 Gln Gly Asp Val Val Ile Ile His Gly Ala Asp Gly Ile Val Asp Val 425 430 435 gat gtt cag gat tat ttg gct aat cag ttc gca tat atg gct gag cgt 1459 Asp Val Gln Asp Tyr Leu Ala Asn Gln Phe Ala Tyr Met Ala Glu Arg 440 445 450 ggt ggg cga gtg gcg tat ctc tac agc tcg atg gac gcg atg ctt ggc 1507 Gly Gly Arg Val Ala Tyr Leu Tyr Ser Ser Met Asp Ala Met Leu Gly 455 460 465 act gtt ggc ttc aat caa ttc caa cgt gct gcg tac acc att ttg ggc 1555 Thr Val Gly Phe Asn Gln Phe Gln Arg Ala Ala Tyr Thr Ile Leu Gly 470 475 480 485 ccg atg aac gtt gac tcg gtg gat act tat caa tct ctg att aat agt 1603 Pro Met Asn Val Asp Ser Val Asp Thr Tyr Gln Ser Leu Ile Asn Ser 490 495 500 cag atc ccg atg gac ttg gca cgg ttg gtg aca acg cag aat tct ggt 1651 Gln Ile Pro Met Asp Leu Ala Arg Leu Val Thr Thr Gln Asn Ser Gly 505 510 515 gcg agc tat ttg cgc cga gga tct acc aat gtg gtg ttt gaa acc aac 1699 Ala Ser Tyr Leu Arg Arg Gly Ser Thr Asn Val Val Phe Glu Thr Asn 520 525 530 ctt gcg ttg ggc gtt aat cct tat atg gag cag cgt cgc aag att gaa 1747 Leu Ala Leu Gly Val Asn Pro Tyr Met Glu Gln Arg Arg Lys Ile Glu 535 540 545 gca cag cga ggt cag cga cga tcc aag cga gac aag cac tac ggt ggt 1795 Ala Gln Arg Gly Gln Arg Arg Ser Lys Arg Asp Lys His Tyr Gly Gly 550 555 560 565 ggc acg acg atg gtg ggc aca gcg gat ctt gat gtt gtc gca att cag 1843 Gly Thr Thr Met Val Gly Thr Ala Asp Leu Asp Val Val Ala Ile Gln 570 575 580 gcg aag gcc gag cac cgc gaa gag cgc ttt gat gag aaa tct gcg cgc 1891 Ala Lys Ala Glu His Arg Glu Glu Arg Phe Asp Glu Lys Ser Ala Arg 585 590 595 aag atg aag gag ctt gat gat gta gaa gcg aaa gaa cta gct ttg aaa 1939 Lys Met Lys Glu Leu Asp Asp Val Glu Ala Lys Glu Leu Ala Leu Lys 600 605 610 act ggg ccg aag aat ctt gat gat gcg ctt gca cag gtg gag aag aag 1987 Thr Gly Pro Lys Asn Leu Asp Asp Ala Leu Ala Gln Val Glu Lys Lys 615 620 625 cgc ctg gcg aag cgg tagttgttgg ctgtggtgaa taaataagca 2032 Arg Leu Ala Lys Arg 630 <210> 350 <211> 634 <212> PRT <213> Corynebacterium glutamicum <400> 350 Val Leu Phe Glu Gln Val Glu Arg Met Lys Gln Ser Trp Ile Asp Asp 1 5 10 15 Asn Leu Lys Asn Thr Asp Arg Leu Ala Lys Thr Glu Glu Ser Asp Leu 20 25 30 Ala Asp Ser Ser Thr Lys Ser Asn Arg Arg Lys Thr Val Lys Arg Gly 35 40 45 Leu Asp Leu Asp Glu Val Ile Ala Glu Leu Asp Asp Gly Ala Ser Tyr 50 55 60 Leu Thr Val His Asn Arg Leu Leu Leu Arg Gly Pro Asn Leu Glu Ile 65 70 75 80 Leu Asp Ser Thr Val Glu Lys Ile Arg Arg Ser Phe Ile Glu His Leu 85 90 95 Ser Arg Met Asp Ile Ala Ala His His Gly Glu Gln Arg Gln Glu Leu 100 105 110 Ser Gln Ile Phe Gly Lys Asn Ser Lys Lys Arg Gly Lys Gly Phe His 115 120 125 Phe Thr Ser Thr Glu Phe Ala Gly Ser Tyr Ser Leu Val Thr Asn Gly 130 135 140 Leu Asn Asp Val Ala Gly Glu Tyr Val Gly Val Met Arg Gly Asp Val 145 150 155 160 Asn Asn Ser Ala Val Leu Phe Asp Val Asp Arg Trp Ser Gly His Val 165 170 175 Val Cys Ala Asp Ser Ser Ile Asn Thr Ser Pro Leu Leu Lys Arg Pro 180 185 190 Arg Val Val Asp Met Trp Gly Ser Lys Ile Ser Gln Ala Ala Leu Leu 195 200 205 Asn Asn Arg Arg Val Val His Leu Val Leu Asn Gly Ala Lys Leu Asp 210 215 220 Glu Met Gly Pro Lys Leu Glu Ser Met Thr Ala His Val Asp Met Thr 225 230 235 240 Ser Gly Asp Leu Asn Met Phe Glu Leu Phe Gly Lys Gln Glu Asp Glu 245 250 255 Leu Ser Leu Tyr Ser Thr His Met Asp Lys Ile Val Phe Met Thr Glu 260 265 270 Gln Ala Leu Gly Asp Lys Thr Ser Glu Leu Ala Leu Leu Arg Gly Lys 275 280 285 Leu Lys Glu Ile Ile Thr Ala Phe Tyr Val Asp Met Lys Met Trp Ala 290 295 300 Leu Asn Ala Gly Glu Asn Arg Asp Lys Leu Arg Leu Val Gly Val Pro 305 310 315 320 His Glu Gln Ile Pro Leu Leu Ser Val Phe Val Ser Tyr Leu Asp Gln 325 330 335 Glu Tyr Glu Arg Gln Lys Tyr Glu Gly Thr Lys Asp Pro Glu Met Phe 340 345 350 Arg Ala Ile Ser Val Leu Arg Leu Thr Tyr Lys Asp Leu Leu Asp Thr 355 360 365 His Gly Asp Leu Phe Asn Gln His Thr Ala Asp Gly Ile Asp Ser Val 370 375 380 Asn Ser Ala Arg Arg Val Ile Tyr Asp Phe Ser Gly Val Leu Arg Arg 385 390 395 400 Gly Ala Gly Val Ala Met Ala Gln Leu Val Asn Val Ile Gly Phe Ala 405 410 415 Val Glu Thr Leu Gly Gln Gly Asp Val Val Ile Ile His Gly Ala Asp 420 425 430 Gly Ile Val Asp Val Asp Val Gln Asp Tyr Leu Ala Asn Gln Phe Ala 435 440 445 Tyr Met Ala Glu Arg Gly Gly Arg Val Ala Tyr Leu Tyr Ser Ser Met 450 455 460 Asp Ala Met Leu Gly Thr Val Gly Phe Asn Gln Phe Gln Arg Ala Ala 465 470 475 480 Tyr Thr Ile Leu Gly Pro Met Asn Val Asp Ser Val Asp Thr Tyr Gln 485 490 495 Ser Leu Ile Asn Ser Gln Ile Pro Met Asp Leu Ala Arg Leu Val Thr 500 505 510 Thr Gln Asn Ser Gly Ala Ser Tyr Leu Arg Arg Gly Ser Thr Asn Val 515 520 525 Val Phe Glu Thr Asn Leu Ala Leu Gly Val Asn Pro Tyr Met Glu Gln 530 535 540 Arg Arg Lys Ile Glu Ala Gln Arg Gly Gln Arg Arg Ser Lys Arg Asp 545 550 555 560 Lys His Tyr Gly Gly Gly Thr Thr Met Val Gly Thr Ala Asp Leu Asp 565 570 575 Val Val Ala Ile Gln Ala Lys Ala Glu His Arg Glu Glu Arg Phe Asp 580 585 590 Glu Lys Ser Ala Arg Lys Met Lys Glu Leu Asp Asp Val Glu Ala Lys 595 600 605 Glu Leu Ala Leu Lys Thr Gly Pro Lys Asn Leu Asp Asp Ala Leu Ala 610 615 620 Gln Val Glu Lys Lys Arg Leu Ala Lys Arg 625 630 <210> 351 <211> 754 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(724) <223> RXA03098 <400> 351 gaccgttttg tcgatcgcac cgctgctggc tcgcaccatc aacgagatct tcgaaaacgg 60 ttccgtcacc accctcttcg agggcgaggc ctaaacaccc atg ccc acc acg gac 115 Met Pro Thr Thr Asp 1 5 gtc ttc aac cgc gtc cgg ttg gca ttg gaa cct cta gct gat ccc gca 163 Val Phe Asn Arg Val Arg Leu Ala Leu Glu Pro Leu Ala Asp Pro Ala 10 15 20 cgt gcc acc gga atg gca agc tac atg cgg gat cag ttt tct ttt ctc 211 Arg Ala Thr Gly Met Ala Ser Tyr Met Arg Asp Gln Phe Ser Phe Leu 25 30 35 ggc atc cca tcc acc ccc aga aaa gaa gcc tgc aaa ccc gtg ctg tcc 259 Gly Ile Pro Ser Thr Pro Arg Lys Glu Ala Cys Lys Pro Val Leu Ser 40 45 50 gcg cta aaa gag ttg gac act gac ttt gtc tca gac tgc ttt ggc gca 307 Ala Leu Lys Glu Leu Asp Thr Asp Phe Val Ser Asp Cys Phe Gly Ala 55 60 65 gct gaa cgg gaa tac cag tat gtc gcc tgc gat cac atc aat cgc gtc 355 Ala Glu Arg Glu Tyr Gln Tyr Val Ala Cys Asp His Ile Asn Arg Val 70 75 80 85 ggc atc acc gat cta ggt ttt gcc aaa gca tta gtg cag acc aaa tcc 403 Gly Ile Thr Asp Leu Gly Phe Ala Lys Ala Leu Val Gln Thr Lys Ser 90 95 100 tgg tgg gac acc gtc gat tcc cta gca aaa ccg atc ggc gcc aaa cac 451 Trp Trp Asp Thr Val Asp Ser Leu Ala Lys Pro Ile Gly Ala Lys His 105 110 115 gat gat gat ctg atg aaa acg tgg gcg ctt gat gag gac ttc tgg gtg 499 Asp Asp Asp Leu Met Lys Thr Trp Ala Leu Asp Glu Asp Phe Trp Val 120 125 130 cgc cgc atc gcg atc atc cac caa ctg ggc cgc aag aaa aac acc gac 547 Arg Arg Ile Ala Ile Ile His Gln Leu Gly Arg Lys Lys Asn Thr Asp 135 140 145 gct gcc ctg ctg gcc tgg atc atc gag cag aac ctc ggc tcc agc gag 595 Ala Ala Leu Leu Ala Trp Ile Ile Glu Gln Asn Leu Gly Ser Ser Glu 150 155 160 165 ttc ttc atc aac aaa gcg atc ggc tgg gca ctg cgg gat ttc gcc cgc 643 Phe Phe Ile Asn Lys Ala Ile Gly Trp Ala Leu Arg Asp Phe Ala Arg 170 175 180 cac gac ccc agc tgg gtc cgg gct ttt gtc gac gcc acg gac ctt tcc 691 His Asp Pro Ser Trp Val Arg Ala Phe Val Asp Ala Thr Asp Leu Ser 185 190 195 cca ctg agc cgg cga gaa gcc ctg aag aat att tagccctcag gcatcatctg 744 Pro Leu Ser Arg Arg Glu Ala Leu Lys Asn Ile 200 205 agcgagtgcc 754 <210> 352 <211> 208 <212> PRT <213> Corynebacterium glutamicum <400> 352 Met Pro Thr Thr Asp Val Phe Asn Arg Val Arg Leu Ala Leu Glu Pro 1 5 10 15 Leu Ala Asp Pro Ala Arg Ala Thr Gly Met Ala Ser Tyr Met Arg Asp 20 25 30 Gln Phe Ser Phe Leu Gly Ile Pro Ser Thr Pro Arg Lys Glu Ala Cys 35 40 45 Lys Pro Val Leu Ser Ala Leu Lys Glu Leu Asp Thr Asp Phe Val Ser 50 55 60 Asp Cys Phe Gly Ala Ala Glu Arg Glu Tyr Gln Tyr Val Ala Cys Asp 65 70 75 80 His Ile Asn Arg Val Gly Ile Thr Asp Leu Gly Phe Ala Lys Ala Leu 85 90 95 Val Gln Thr Lys Ser Trp Trp Asp Thr Val Asp Ser Leu Ala Lys Pro 100 105 110 Ile Gly Ala Lys His Asp Asp Asp Leu Met Lys Thr Trp Ala Leu Asp 115 120 125 Glu Asp Phe Trp Val Arg Arg Ile Ala Ile Ile His Gln Leu Gly Arg 130 135 140 Lys Lys Asn Thr Asp Ala Ala Leu Leu Ala Trp Ile Ile Glu Gln Asn 145 150 155 160 Leu Gly Ser Ser Glu Phe Phe Ile Asn Lys Ala Ile Gly Trp Ala Leu 165 170 175 Arg Asp Phe Ala Arg His Asp Pro Ser Trp Val Arg Ala Phe Val Asp 180 185 190 Ala Thr Asp Leu Ser Pro Leu Ser Arg Arg Glu Ala Leu Lys Asn Ile 195 200 205 <210> 353 <211> 1729 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1699) <223> RXA03113 <400> 353 gttggatctt gcattgaaaa aatgaaaacc tcgtcgggaa tgcaacttgg gatcacgtct 60 cgggcaagaa acgtccttaa aaaaagggga gtgattgtga gtg ctt gat ttc tta 115 Val Leu Asp Phe Leu 1 5 gct gcg aac ccg ctg att gcg ctg gtg gtt att ttg gcc gtt ggt tta 163 Ala Ala Asn Pro Leu Ile Ala Leu Val Val Ile Leu Ala Val Gly Leu 10 15 20 gca att ggt cag att agg gtc ttt ggc ctt tct tta ggt gcc gcc gcg 211 Ala Ile Gly Gln Ile Arg Val Phe Gly Leu Ser Leu Gly Ala Ala Ala 25 30 35 gtg ctg ttt gtg gcc ctg gtg gtt tca act gca aat acc gac atc gtc 259 Val Leu Phe Val Ala Leu Val Val Ser Thr Ala Asn Thr Asp Ile Val 40 45 50 atc ccc atg att gtt tat cag ctg ggc ttg gcg atg ttc gtt tat gtc 307 Ile Pro Met Ile Val Tyr Gln Leu Gly Leu Ala Met Phe Val Tyr Val 55 60 65 atc ggt ttg tcc gcc gga cca gca ttt ttc agt gag ttc gct aaa aag 355 Ile Gly Leu Ser Ala Gly Pro Ala Phe Phe Ser Glu Phe Ala Lys Lys 70 75 80 85 ggc tgg aag ctc acc atc ttt atg ctc ctg ctg ctg gca aca ctg att 403 Gly Trp Lys Leu Thr Ile Phe Met Leu Leu Leu Leu Ala Thr Leu Ile 90 95 100 ggt ttg gcg tgg gtg ctt att aag tca ctg ggg ctt gat gca gcg atc 451 Gly Leu Ala Trp Val Leu Ile Lys Ser Leu Gly Leu Asp Ala Ala Ile 105 110 115 ggt acc ggt atg ttc acc ggc gcg ctg acc tcg act ccc ggt atg gca 499 Gly Thr Gly Met Phe Thr Gly Ala Leu Thr Ser Thr Pro Gly Met Ala 120 125 130 gcg gtc gtg gaa ttg att gaa gga atc gat cca agc ctt gcc agt gaa 547 Ala Val Val Glu Leu Ile Glu Gly Ile Asp Pro Ser Leu Ala Ser Glu 135 140 145 cct gtt att ggt tat tcc ttg gca tat ccg gga gcc gtg ctg gga tcc 595 Pro Val Ile Gly Tyr Ser Leu Ala Tyr Pro Gly Ala Val Leu Gly Ser 150 155 160 165 att gtg gtg gcc gcg gtt gga gcg aaa ctg ctc aaa gta aat cac cgg 643 Ile Val Val Ala Ala Val Gly Ala Lys Leu Leu Lys Val Asn His Arg 170 175 180 gaa gat gct cga aaa gaa ggc atg atc acc gca ccg ctg gtg tgg aag 691 Glu Asp Ala Arg Lys Glu Gly Met Ile Thr Ala Pro Leu Val Trp Lys 185 190 195 ggt gtg cag ctc aaa cct gga atc aca ggc agg gtg gga gat ctt cca 739 Gly Val Gln Leu Lys Pro Gly Ile Thr Gly Arg Val Gly Asp Leu Pro 200 205 210 cgc ctt gca ggt gaa agt atc atc gca acc cgc att gtg gat gat cca 787 Arg Leu Ala Gly Glu Ser Ile Ile Ala Thr Arg Ile Val Asp Asp Pro 215 220 225 cat aca cac cgc ctc gcg gat cca gat ctg ccg att act gaa ggc atg 835 His Thr His Arg Leu Ala Asp Pro Asp Leu Pro Ile Thr Glu Gly Met 230 235 240 245 gaa ctg ttg atc aac ggc act gaa gaa gcc gtg gat cgg gca att aag 883 Glu Leu Leu Ile Asn Gly Thr Glu Glu Ala Val Asp Arg Ala Ile Lys 250 255 260 gcg ttg ggt gaa gaa cgc gaa acc aaa att gag gac aca gag ctg atc 931 Ala Leu Gly Glu Glu Arg Glu Thr Lys Ile Glu Asp Thr Glu Leu Ile 265 270 275 tac acc cgc ctg acg gta tct agc cct gag gtt gca ggt aga acc gtt 979 Tyr Thr Arg Leu Thr Val Ser Ser Pro Glu Val Ala Gly Arg Thr Val 280 285 290 gct gag ctt gat act gta gct cac gga ttc atg att gcc cgt atc cgc 1027 Ala Glu Leu Asp Thr Val Ala His Gly Phe Met Ile Ala Arg Ile Arg 295 300 305 cag ggc gat tct gag gta gtg cct aaa cct gac acc gtg atc aac tac 1075 Gln Gly Asp Ser Glu Val Val Pro Lys Pro Asp Thr Val Ile Asn Tyr 310 315 320 325 tct gac cgc atc cgc gtg gtg gtt gct cct ggt cgt gtg gct gaa gtg 1123 Ser Asp Arg Ile Arg Val Val Val Ala Pro Gly Arg Val Ala Glu Val 330 335 340 cga cga ttc tta ggg gac tct gaa aag tcc ctt gct gat gtt aat ctg 1171 Arg Arg Phe Leu Gly Asp Ser Glu Lys Ser Leu Ala Asp Val Asn Leu 345 350 355 ctg cct tta gcc atc gga tta tct ctt ggc ctg ttg ttg ggc gcg atc 1219 Leu Pro Leu Ala Ile Gly Leu Ser Leu Gly Leu Leu Leu Gly Ala Ile 360 365 370 ccg att cct ctt cca ggc ggc acc acg atg tcc ctt ggc ttt ggt ggc 1267 Pro Ile Pro Leu Pro Gly Gly Thr Thr Met Ser Leu Gly Phe Gly Gly 375 380 385 ggc ccg att att gcc ggc ctg att ttg gga gca ctc aag cac aca gga 1315 Gly Pro Ile Ile Ala Gly Leu Ile Leu Gly Ala Leu Lys His Thr Gly 390 395 400 405 ccg ctg acg tgg cag atg ccg ttc cac gcc aac cgc acg atc tcc acc 1363 Pro Leu Thr Trp Gln Met Pro Phe His Ala Asn Arg Thr Ile Ser Thr 410 415 420 ttg ggc ctg gcg ctg ttt ttg gct ggt gtg ggt acc tct gca ggt gca 1411 Leu Gly Leu Ala Leu Phe Leu Ala Gly Val Gly Thr Ser Ala Gly Ala 425 430 435 gga ttt aga gct gcg ctt acc gat tcc tcc tcc ttg atc tac atg gcc 1459 Gly Phe Arg Ala Ala Leu Thr Asp Ser Ser Ser Leu Ile Tyr Met Ala 440 445 450 ggt ggc ttg gtg atc acc ttg gcc tct gcg ctg ctg tgt gct gtg atc 1507 Gly Gly Leu Val Ile Thr Leu Ala Ser Ala Leu Leu Cys Ala Val Ile 455 460 465 ggc atg tgg gta ctc agg ttg agg tgg gat gaa gcc atg ggt gtt gcc 1555 Gly Met Trp Val Leu Arg Leu Arg Trp Asp Glu Ala Met Gly Val Ala 470 475 480 485 gct ggc acc acc aca aat cct gca att att tcc tat ctg aat ggg caa 1603 Ala Gly Thr Thr Thr Asn Pro Ala Ile Ile Ser Tyr Leu Asn Gly Gln 490 495 500 acc gga acg gat ctt gcc aac agg gga tat gcc act gtg tac ccc acg 1651 Thr Gly Thr Asp Leu Ala Asn Arg Gly Tyr Ala Thr Val Tyr Pro Thr 505 510 515 gcg atg atc ggt aaa atc ctc ggc gcg cag ata ttg ttc ttg ctg ctc 1699 Ala Met Ile Gly Lys Ile Leu Gly Ala Gln Ile Leu Phe Leu Leu Leu 520 525 530 taaggtgatt tttgggcagt ggtgggggtg 1729 <210> 354 <211> 533 <212> PRT <213> Corynebacterium glutamicum <400> 354 Val Leu Asp Phe Leu Ala Ala Asn Pro Leu Ile Ala Leu Val Val Ile 1 5 10 15 Leu Ala Val Gly Leu Ala Ile Gly Gln Ile Arg Val Phe Gly Leu Ser 20 25 30 Leu Gly Ala Ala Ala Val Leu Phe Val Ala Leu Val Val Ser Thr Ala 35 40 45 Asn Thr Asp Ile Val Ile Pro Met Ile Val Tyr Gln Leu Gly Leu Ala 50 55 60 Met Phe Val Tyr Val Ile Gly Leu Ser Ala Gly Pro Ala Phe Phe Ser 65 70 75 80 Glu Phe Ala Lys Lys Gly Trp Lys Leu Thr Ile Phe Met Leu Leu Leu 85 90 95 Leu Ala Thr Leu Ile Gly Leu Ala Trp Val Leu Ile Lys Ser Leu Gly 100 105 110 Leu Asp Ala Ala Ile Gly Thr Gly Met Phe Thr Gly Ala Leu Thr Ser 115 120 125 Thr Pro Gly Met Ala Ala Val Val Glu Leu Ile Glu Gly Ile Asp Pro 130 135 140 Ser Leu Ala Ser Glu Pro Val Ile Gly Tyr Ser Leu Ala Tyr Pro Gly 145 150 155 160 Ala Val Leu Gly Ser Ile Val Val Ala Ala Val Gly Ala Lys Leu Leu 165 170 175 Lys Val Asn His Arg Glu Asp Ala Arg Lys Glu Gly Met Ile Thr Ala 180 185 190 Pro Leu Val Trp Lys Gly Val Gln Leu Lys Pro Gly Ile Thr Gly Arg 195 200 205 Val Gly Asp Leu Pro Arg Leu Ala Gly Glu Ser Ile Ile Ala Thr Arg 210 215 220 Ile Val Asp Asp Pro His Thr His Arg Leu Ala Asp Pro Asp Leu Pro 225 230 235 240 Ile Thr Glu Gly Met Glu Leu Leu Ile Asn Gly Thr Glu Glu Ala Val 245 250 255 Asp Arg Ala Ile Lys Ala Leu Gly Glu Glu Arg Glu Thr Lys Ile Glu 260 265 270 Asp Thr Glu Leu Ile Tyr Thr Arg Leu Thr Val Ser Ser Pro Glu Val 275 280 285 Ala Gly Arg Thr Val Ala Glu Leu Asp Thr Val Ala His Gly Phe Met 290 295 300 Ile Ala Arg Ile Arg Gln Gly Asp Ser Glu Val Val Pro Lys Pro Asp 305 310 315 320 Thr Val Ile Asn Tyr Ser Asp Arg Ile Arg Val Val Val Ala Pro Gly 325 330 335 Arg Val Ala Glu Val Arg Arg Phe Leu Gly Asp Ser Glu Lys Ser Leu 340 345 350 Ala Asp Val Asn Leu Leu Pro Leu Ala Ile Gly Leu Ser Leu Gly Leu 355 360 365 Leu Leu Gly Ala Ile Pro Ile Pro Leu Pro Gly Gly Thr Thr Met Ser 370 375 380 Leu Gly Phe Gly Gly Gly Pro Ile Ile Ala Gly Leu Ile Leu Gly Ala 385 390 395 400 Leu Lys His Thr Gly Pro Leu Thr Trp Gln Met Pro Phe His Ala Asn 405 410 415 Arg Thr Ile Ser Thr Leu Gly Leu Ala Leu Phe Leu Ala Gly Val Gly 420 425 430 Thr Ser Ala Gly Ala Gly Phe Arg Ala Ala Leu Thr Asp Ser Ser Ser 435 440 445 Leu Ile Tyr Met Ala Gly Gly Leu Val Ile Thr Leu Ala Ser Ala Leu 450 455 460 Leu Cys Ala Val Ile Gly Met Trp Val Leu Arg Leu Arg Trp Asp Glu 465 470 475 480 Ala Met Gly Val Ala Ala Gly Thr Thr Thr Asn Pro Ala Ile Ile Ser 485 490 495 Tyr Leu Asn Gly Gln Thr Gly Thr Asp Leu Ala Asn Arg Gly Tyr Ala 500 505 510 Thr Val Tyr Pro Thr Ala Met Ile Gly Lys Ile Leu Gly Ala Gln Ile 515 520 525 Leu Phe Leu Leu Leu 530 <210> 355 <211> 811 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(781) <223> RXA03184 <400> 355 taccaaaaca atctgccgat taagtaggaa gtccccaatg accgccgttt tgctcctcac 60 tctttttcta tctcttttta ttggcatttc gctaggactg ttg ggc ggt ggt ggt 115 Leu Gly Gly Gly Gly 1 5 tcg atc ctc act gtt cca att ctg acg tat gtg gcg ggg ttg gag cct 163 Ser Ile Leu Thr Val Pro Ile Leu Thr Tyr Val Ala Gly Leu Glu Pro 10 15 20 cgt gaa gct att gcc gcc tcg ctg ttt att gtg ggc aca acg tcg ctg 211 Arg Glu Ala Ile Ala Ala Ser Leu Phe Ile Val Gly Thr Thr Ser Leu 25 30 35 gtc agt gcc att agt cac gca aga aat ggg cgg gtc cgg tgg aag act 259 Val Ser Ala Ile Ser His Ala Arg Asn Gly Arg Val Arg Trp Lys Thr 40 45 50 ggc ctg ctg ttt ggt gcc gcg ggc atg gtt ggc gcg ttt ggc ggt ggc 307 Gly Leu Leu Phe Gly Ala Ala Gly Met Val Gly Ala Phe Gly Gly Gly 55 60 65 gtt ctc ggg ggc tac att cct ggc acg att ttg atg atc gcg ttt gcg 355 Val Leu Gly Gly Tyr Ile Pro Gly Thr Ile Leu Met Ile Ala Phe Ala 70 75 80 85 ctc atg atg atc gcc acg tcg act gcg atg ttg cgg ggg cgt aag cag 403 Leu Met Met Ile Ala Thr Ser Thr Ala Met Leu Arg Gly Arg Lys Gln 90 95 100 aag aag ggg gcg tcg aaa agc tct ctt tgg cgc gtc ctt gtt gat ggc 451 Lys Lys Gly Ala Ser Lys Ser Ser Leu Trp Arg Val Leu Val Asp Gly 105 110 115 ctg gtg gtc ggc gcg gtg acc ggg ctt gtt ggt gcg ggc ggc ggc ttt 499 Leu Val Val Gly Ala Val Thr Gly Leu Val Gly Ala Gly Gly Gly Phe 120 125 130 ttg gtg gtg ccg gcg ctg gcg ctg ctc ggc ggg ctg tcg atg ccg gtg 547 Leu Val Val Pro Ala Leu Ala Leu Leu Gly Gly Leu Ser Met Pro Val 135 140 145 gct gtg ggc acg tcg ttg gtg gtg atc acg atg aag tcg ttt gcg ggg 595 Ala Val Gly Thr Ser Leu Val Val Ile Thr Met Lys Ser Phe Ala Gly 150 155 160 165 ctt gcc ggg tat ctg acc agc gtg cag ctg gat tgg ggg ctg gtg ctg 643 Leu Ala Gly Tyr Leu Thr Ser Val Gln Leu Asp Trp Gly Leu Val Leu 170 175 180 atg gtg act gcg gcc gcc atc gtc ggt tcg ctt gcc ggt tcg cgc ctt 691 Met Val Thr Ala Ala Ala Ile Val Gly Ser Leu Ala Gly Ser Arg Leu 185 190 195 gcg ggg cgc gtg cct gag act ttg ctc cgc aaa ggg ttc ggg gtg ttc 739 Ala Gly Arg Val Pro Glu Thr Leu Leu Arg Lys Gly Phe Gly Val Phe 200 205 210 gtg ctg gtc atg ggc gtg ttc gtg ctc ggc ttg gag ctt tta 781 Val Leu Val Met Gly Val Phe Val Leu Gly Leu Glu Leu Leu 215 220 225 taagcttttc gacgtctccc tccggcgaaa 811 <210> 356 <211> 227 <212> PRT <213> Corynebacterium glutamicum <400> 356 Leu Gly Gly Gly Gly Ser Ile Leu Thr Val Pro Ile Leu Thr Tyr Val 1 5 10 15 Ala Gly Leu Glu Pro Arg Glu Ala Ile Ala Ala Ser Leu Phe Ile Val 20 25 30 Gly Thr Thr Ser Leu Val Ser Ala Ile Ser His Ala Arg Asn Gly Arg 35 40 45 Val Arg Trp Lys Thr Gly Leu Leu Phe Gly Ala Ala Gly Met Val Gly 50 55 60 Ala Phe Gly Gly Gly Val Leu Gly Gly Tyr Ile Pro Gly Thr Ile Leu 65 70 75 80 Met Ile Ala Phe Ala Leu Met Met Ile Ala Thr Ser Thr Ala Met Leu 85 90 95 Arg Gly Arg Lys Gln Lys Lys Gly Ala Ser Lys Ser Ser Leu Trp Arg 100 105 110 Val Leu Val Asp Gly Leu Val Val Gly Ala Val Thr Gly Leu Val Gly 115 120 125 Ala Gly Gly Gly Phe Leu Val Val Pro Ala Leu Ala Leu Leu Gly Gly 130 135 140 Leu Ser Met Pro Val Ala Val Gly Thr Ser Leu Val Val Ile Thr Met 145 150 155 160 Lys Ser Phe Ala Gly Leu Ala Gly Tyr Leu Thr Ser Val Gln Leu Asp 165 170 175 Trp Gly Leu Val Leu Met Val Thr Ala Ala Ala Ile Val Gly Ser Leu 180 185 190 Ala Gly Ser Arg Leu Ala Gly Arg Val Pro Glu Thr Leu Leu Arg Lys 195 200 205 Gly Phe Gly Val Phe Val Leu Val Met Gly Val Phe Val Leu Gly Leu 210 215 220 Glu Leu Leu 225 <210> 357 <211> 601 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(571) <223> RXA03316 <400> 357 tctgcgttaa gttcgacttc ttaacaccga cttcagtgag aaaacctgac atcgccgtat 60 ttcccaaacg caactgtgtg ctgagataag atcagtaatc atg act tac aaa gca 115 Met Thr Tyr Lys Ala 1 5 gac tat gat ctt gac ttt gaa aaa gta gtc ttc cgc atg tca cag ctg 163 Asp Tyr Asp Leu Asp Phe Glu Lys Val Val Phe Arg Met Ser Gln Leu 10 15 20 ttt gaa gat ctc atc ccg tca gaa aac gcc tac gac cca tac aaa aaa 211 Phe Glu Asp Leu Ile Pro Ser Glu Asn Ala Tyr Asp Pro Tyr Lys Lys 25 30 35 tca acg tgg ccg act ctg acc atg gct gca aca tgg gta cag gac gac 259 Ser Thr Trp Pro Thr Leu Thr Met Ala Ala Thr Trp Val Gln Asp Asp 40 45 50 tgt ctc ata gtt gta ttt agg gct gat cca aga aga gtt gcg cca atg 307 Cys Leu Ile Val Val Phe Arg Ala Asp Pro Arg Arg Val Ala Pro Met 55 60 65 gat ggt gcg act ttc gtg ggc tac ttt tgc aag att tac ccc caa tac 355 Asp Gly Ala Thr Phe Val Gly Tyr Phe Cys Lys Ile Tyr Pro Gln Tyr 70 75 80 85 att cct gac aat atc gaa ttt ggg gca gta gag cta atg tat gcc gac 403 Ile Pro Asp Asn Ile Glu Phe Gly Ala Val Glu Leu Met Tyr Ala Asp 90 95 100 tgg atg gca ggt gat ggg ttt att tgg aag atc gat ctc aag gct ccg 451 Trp Met Ala Gly Asp Gly Phe Ile Trp Lys Ile Asp Leu Lys Ala Pro 105 110 115 caa aag ata cat tgg aga aat gca ttc gat ggt cta aaa gct ccg gca 499 Gln Lys Ile His Trp Arg Asn Ala Phe Asp Gly Leu Lys Ala Pro Ala 120 125 130 gat tta gag gaa tta ttg gac tac gcc gcg gag att ccg atg tgg tta 547 Asp Leu Glu Glu Leu Leu Asp Tyr Ala Ala Glu Ile Pro Met Trp Leu 135 140 145 aac ccg gaa att gaa aag tgg atg tagccagctt caaatttgaa taccccttga 601 Asn Pro Glu Ile Glu Lys Trp Met 150 155 <210> 358 <211> 157 <212> PRT <213> Corynebacterium glutamicum <400> 358 Met Thr Tyr Lys Ala Asp Tyr Asp Leu Asp Phe Glu Lys Val Val Phe 1 5 10 15 Arg Met Ser Gln Leu Phe Glu Asp Leu Ile Pro Ser Glu Asn Ala Tyr 20 25 30 Asp Pro Tyr Lys Lys Ser Thr Trp Pro Thr Leu Thr Met Ala Ala Thr 35 40 45 Trp Val Gln Asp Asp Cys Leu Ile Val Val Phe Arg Ala Asp Pro Arg 50 55 60 Arg Val Ala Pro Met Asp Gly Ala Thr Phe Val Gly Tyr Phe Cys Lys 65 70 75 80 Ile Tyr Pro Gln Tyr Ile Pro Asp Asn Ile Glu Phe Gly Ala Val Glu 85 90 95 Leu Met Tyr Ala Asp Trp Met Ala Gly Asp Gly Phe Ile Trp Lys Ile 100 105 110 Asp Leu Lys Ala Pro Gln Lys Ile His Trp Arg Asn Ala Phe Asp Gly 115 120 125 Leu Lys Ala Pro Ala Asp Leu Glu Glu Leu Leu Asp Tyr Ala Ala Glu 130 135 140 Ile Pro Met Trp Leu Asn Pro Glu Ile Glu Lys Trp Met 145 150 155 <210> 359 <211> 1213 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1183) <223> RXA03343 <400> 359 ccgcgctctg atctggtact tctgagatag tcagcaaatc tgatatagga aaactcctta 60 tcagaggaag tatagattgt gaattttgaa ggattacgcg gtg cat act cgt ggg 115 Val His Thr Arg Gly 1 5 tta gtt tct ctc tta agt ctt att ttt ctt ttc gtt ctt tca ggg tgt 163 Leu Val Ser Leu Leu Ser Leu Ile Phe Leu Phe Val Leu Ser Gly Cys 10 15 20 gga ggg aat gcc act acc gct gat gaa gct gct gaa agt gac gtt gtt 211 Gly Gly Asn Ala Thr Thr Ala Asp Glu Ala Ala Glu Ser Asp Val Val 25 30 35 act tca agt agc gca cct cca agt aaa cga gct cta gat gtt gga gaa 259 Thr Ser Ser Ser Ala Pro Pro Ser Lys Arg Ala Leu Asp Val Gly Glu 40 45 50 gca gta gag atc cca ggg gtc gtg ctc acg gta aac agc gtc aca cag 307 Ala Val Glu Ile Pro Gly Val Val Leu Thr Val Asn Ser Val Thr Gln 55 60 65 tcc gat cag ctc atg ttg tac tca gaa ggc agt gcg cgt gga tct gag 355 Ser Asp Gln Leu Met Leu Tyr Ser Glu Gly Ser Ala Arg Gly Ser Glu 70 75 80 85 ccg aga gaa cag cgg aat gct gcg tcc gga gaa aag ttt gtt tcg gtg 403 Pro Arg Glu Gln Arg Asn Ala Ala Ser Gly Glu Lys Phe Val Ser Val 90 95 100 gac act acc gtg aag aat tcg agc tct gat cct tgg gat ctt tca tgt 451 Asp Thr Thr Val Lys Asn Ser Ser Ser Asp Pro Trp Asp Leu Ser Cys 105 110 115 ggt cac gta tta cag aca tgg ctc ctc gag gac gaa cta gat gat caa 499 Gly His Val Leu Gln Thr Trp Leu Leu Glu Asp Glu Leu Asp Asp Gln 120 125 130 caa ggt gac caa gaa aag aaa ttt agc cct atc gac aat ctt gat cag 547 Gln Gly Asp Gln Glu Lys Lys Phe Ser Pro Ile Asp Asn Leu Asp Gln 135 140 145 att tct ggt aat ccg gag tgt ggt gtg ctt tta gaa gtg ggt aca gaa 595 Ile Ser Gly Asn Pro Glu Cys Gly Val Leu Leu Glu Val Gly Thr Glu 150 155 160 165 att gaa atg acg tgg tct ttt act att cca gat gac ata gaa atc act 643 Ile Glu Met Thr Trp Ser Phe Thr Ile Pro Asp Asp Ile Glu Ile Thr 170 175 180 cac ttt ggt ttt tct ctt tcg gat agc act tcc aat gac ttg gcc att 691 His Phe Gly Phe Ser Leu Ser Asp Ser Thr Ser Asn Asp Leu Ala Ile 185 190 195 atc agc ctt ggg ggt gca ata gag aca tcg tcg gcc atc aca aca act 739 Ile Ser Leu Gly Gly Ala Ile Glu Thr Ser Ser Ala Ile Thr Thr Thr 200 205 210 gaa gtt ata gca ccg gaa aat gac acg gaa acg ctg cta gag ata act 787 Glu Val Ile Ala Pro Glu Asn Asp Thr Glu Thr Leu Leu Glu Ile Thr 215 220 225 ccg gtt gac tgt cag gtc ggc ctt ggc ccc atc gtt act tct tgg tcg 835 Pro Val Asp Cys Gln Val Gly Leu Gly Pro Ile Val Thr Ser Trp Ser 230 235 240 245 gat gga acg gtc gga ggt tgg tct cag cac tgt cag gac gtg cat gat 883 Asp Gly Thr Val Gly Gly Trp Ser Gln His Cys Gln Asp Val His Asp 250 255 260 gag gta ctt gcc ggt gaa gtc gca gcg aat acc cca gta tgt gac gga 931 Glu Val Leu Ala Gly Glu Val Ala Ala Asn Thr Pro Val Cys Asp Gly 265 270 275 gtt gta tgc act tac ccc agt ggc gcc aca atg ccg gat cca aat gca 979 Val Val Cys Thr Tyr Pro Ser Gly Ala Thr Met Pro Asp Pro Asn Ala 280 285 290 cct caa atc cct tca gat acg agt ggt gca gtg tgc gat gaa aat cag 1027 Pro Gln Ile Pro Ser Asp Thr Ser Gly Ala Val Cys Asp Glu Asn Gln 295 300 305 tgt gtt tac cct aac ggt tat atc gcc cga att ggg gat ccg aat gtt 1075 Cys Val Tyr Pro Asn Gly Tyr Ile Ala Arg Ile Gly Asp Pro Asn Val 310 315 320 325 ccg aac tat ctc aag cct ggc aac tct ccg tgg gta caa gga cag att 1123 Pro Asn Tyr Leu Lys Pro Gly Asn Ser Pro Trp Val Gln Gly Gln Ile 330 335 340 gat ttt cag aat tgc cta gac agt ggg aaa act att gag caa tgc cgt 1171 Asp Phe Gln Asn Cys Leu Asp Ser Gly Lys Thr Ile Glu Gln Cys Arg 345 350 355 gaa gaa ctg aac taggtcagtc ttaagaaatc acccagcccg 1213 Glu Glu Leu Asn 360 <210> 360 <211> 361 <212> PRT <213> Corynebacterium glutamicum <400> 360 Val His Thr Arg Gly Leu Val Ser Leu Leu Ser Leu Ile Phe Leu Phe 1 5 10 15 Val Leu Ser Gly Cys Gly Gly Asn Ala Thr Thr Ala Asp Glu Ala Ala 20 25 30 Glu Ser Asp Val Val Thr Ser Ser Ser Ala Pro Pro Ser Lys Arg Ala 35 40 45 Leu Asp Val Gly Glu Ala Val Glu Ile Pro Gly Val Val Leu Thr Val 50 55 60 Asn Ser Val Thr Gln Ser Asp Gln Leu Met Leu Tyr Ser Glu Gly Ser 65 70 75 80 Ala Arg Gly Ser Glu Pro Arg Glu Gln Arg Asn Ala Ala Ser Gly Glu 85 90 95 Lys Phe Val Ser Val Asp Thr Thr Val Lys Asn Ser Ser Ser Asp Pro 100 105 110 Trp Asp Leu Ser Cys Gly His Val Leu Gln Thr Trp Leu Leu Glu Asp 115 120 125 Glu Leu Asp Asp Gln Gln Gly Asp Gln Glu Lys Lys Phe Ser Pro Ile 130 135 140 Asp Asn Leu Asp Gln Ile Ser Gly Asn Pro Glu Cys Gly Val Leu Leu 145 150 155 160 Glu Val Gly Thr Glu Ile Glu Met Thr Trp Ser Phe Thr Ile Pro Asp 165 170 175 Asp Ile Glu Ile Thr His Phe Gly Phe Ser Leu Ser Asp Ser Thr Ser 180 185 190 Asn Asp Leu Ala Ile Ile Ser Leu Gly Gly Ala Ile Glu Thr Ser Ser 195 200 205 Ala Ile Thr Thr Thr Glu Val Ile Ala Pro Glu Asn Asp Thr Glu Thr 210 215 220 Leu Leu Glu Ile Thr Pro Val Asp Cys Gln Val Gly Leu Gly Pro Ile 225 230 235 240 Val Thr Ser Trp Ser Asp Gly Thr Val Gly Gly Trp Ser Gln His Cys 245 250 255 Gln Asp Val His Asp Glu Val Leu Ala Gly Glu Val Ala Ala Asn Thr 260 265 270 Pro Val Cys Asp Gly Val Val Cys Thr Tyr Pro Ser Gly Ala Thr Met 275 280 285 Pro Asp Pro Asn Ala Pro Gln Ile Pro Ser Asp Thr Ser Gly Ala Val 290 295 300 Cys Asp Glu Asn Gln Cys Val Tyr Pro Asn Gly Tyr Ile Ala Arg Ile 305 310 315 320 Gly Asp Pro Asn Val Pro Asn Tyr Leu Lys Pro Gly Asn Ser Pro Trp 325 330 335 Val Gln Gly Gln Ile Asp Phe Gln Asn Cys Leu Asp Ser Gly Lys Thr 340 345 350 Ile Glu Gln Cys Arg Glu Glu Leu Asn 355 360 <210> 361 <211> 556 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(526) <223> RXA03377 <400> 361 ttcctctcca gggcacaatt tacccccatt gaactgcatc aatgggggtt catcatttcc 60 tccaaagtgc aaaaatacac gcttacgtac actgtagatc atg cta cag agc ccg 115 Met Leu Gln Ser Pro 1 5 aag aga gcc atc ggc ctg tcc gcc gca ttg ctc acg ctc acc gcg tgt 163 Lys Arg Ala Ile Gly Leu Ser Ala Ala Leu Leu Thr Leu Thr Ala Cys 10 15 20 ggg gca aac gac gag ctt tcc agt tat ctc acc tcc att gag aca gct 211 Gly Ala Asn Asp Glu Leu Ser Ser Tyr Leu Thr Ser Ile Glu Thr Ala 25 30 35 aca gct caa gtt tcc ctc aac gac att tac aac gat caa tgg tcc gaa 259 Thr Ala Gln Val Ser Leu Asn Asp Ile Tyr Asn Asp Gln Trp Ser Glu 40 45 50 ttt gca gtc gtt tgc ccc tac acg cca agt gac tat gcg aag gcg gaa 307 Phe Ala Val Val Cys Pro Tyr Thr Pro Ser Asp Tyr Ala Lys Ala Glu 55 60 65 ctt gac gtc gga gat acc ccc tgg cca gat aag tgg cca gac gaa caa 355 Leu Asp Val Gly Asp Thr Pro Trp Pro Asp Lys Trp Pro Asp Glu Gln 70 75 80 85 acc aat ttt ctt ctc cta aaa agt gac acg ggc gaa tac aaa tgg gtg 403 Thr Asn Phe Leu Leu Leu Lys Ser Asp Thr Gly Glu Tyr Lys Trp Val 90 95 100 cga tat cgc agg tca aac ctc gac ttt tgc tct gaa cca agg att gac 451 Arg Tyr Arg Arg Ser Asn Leu Asp Phe Cys Ser Glu Pro Arg Ile Asp 105 110 115 ttc acg ctc ttc ccc act gct gca acg ctg gaa ttc acc gct aac gat 499 Phe Thr Leu Phe Pro Thr Ala Ala Thr Leu Glu Phe Thr Ala Asn Asp 120 125 130 ggc tgg att ctc gag tct gta cac cct tgatcaaagc ccgagtgttc 546 Gly Trp Ile Leu Glu Ser Val His Pro 135 140 cgtagattaa 556 <210> 362 <211> 142 <212> PRT <213> Corynebacterium glutamicum <400> 362 Met Leu Gln Ser Pro Lys Arg Ala Ile Gly Leu Ser Ala Ala Leu Leu 1 5 10 15 Thr Leu Thr Ala Cys Gly Ala Asn Asp Glu Leu Ser Ser Tyr Leu Thr 20 25 30 Ser Ile Glu Thr Ala Thr Ala Gln Val Ser Leu Asn Asp Ile Tyr Asn 35 40 45 Asp Gln Trp Ser Glu Phe Ala Val Val Cys Pro Tyr Thr Pro Ser Asp 50 55 60 Tyr Ala Lys Ala Glu Leu Asp Val Gly Asp Thr Pro Trp Pro Asp Lys 65 70 75 80 Trp Pro Asp Glu Gln Thr Asn Phe Leu Leu Leu Lys Ser Asp Thr Gly 85 90 95 Glu Tyr Lys Trp Val Arg Tyr Arg Arg Ser Asn Leu Asp Phe Cys Ser 100 105 110 Glu Pro Arg Ile Asp Phe Thr Leu Phe Pro Thr Ala Ala Thr Leu Glu 115 120 125 Phe Thr Ala Asn Asp Gly Trp Ile Leu Glu Ser Val His Pro 130 135 140 <210> 363 <211> 304 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(274) <223> RXA03463 <400> 363 atagttcgcg ctgttttaag aggttgagat tctcaaacgg gtgtttgtat agatcacatt 60 gcgatcatgc cttagacgcg attctgagag ggcaagtttt ttg agt tcc ggt tcc 115 Leu Ser Ser Gly Ser 1 5 aat ttt aag ctc gac caa acc aca gtg ccc acg aac tgg aaa ttc gac 163 Asn Phe Lys Leu Asp Gln Thr Thr Val Pro Thr Asn Trp Lys Phe Asp 10 15 20 aac tct ggg cat ttg tgt ctg gtt tca agc cgt cga aac cag acc acg 211 Asn Ser Gly His Leu Cys Leu Val Ser Ser Arg Arg Asn Gln Thr Thr 25 30 35 ctg ccc atg aac cgg gaa aac ctg agc cgt ggg cag tgt ggt ttg gtc 259 Leu Pro Met Asn Arg Glu Asn Leu Ser Arg Gly Gln Cys Gly Leu Val 40 45 50 atg gcg ttc gaa tgc tgattcgggc cagacaggcg tgacaagatt 304 Met Ala Phe Glu Cys 55 <210> 364 <211> 58 <212> PRT <213> Corynebacterium glutamicum <400> 364 Leu Ser Ser Gly Ser Asn Phe Lys Leu Asp Gln Thr Thr Val Pro Thr 1 5 10 15 Asn Trp Lys Phe Asp Asn Ser Gly His Leu Cys Leu Val Ser Ser Arg 20 25 30 Arg Asn Gln Thr Thr Leu Pro Met Asn Arg Glu Asn Leu Ser Arg Gly 35 40 45 Gln Cys Gly Leu Val Met Ala Phe Glu Cys 50 55 <210> 365 <211> 496 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(466) <223> RXA03506 <400> 365 cgcacaaagt gggtgtgaaa actccgcttc atgaccttat ttatgctggt cttaagctga 60 aagaagagga aaattcactt tagggataga atcaagatcc atg atc gtt aca tcc 115 Met Ile Val Thr Ser 1 5 acc gcg cgc gtt tct ata gat cgt ccc tcg cgc tat gcc aaa cag tta 163 Thr Ala Arg Val Ser Ile Asp Arg Pro Ser Arg Tyr Ala Lys Gln Leu 10 15 20 act agc cat ttg ggt gaa aaa ctg agc aca agc tgg gac ccg gag gca 211 Thr Ser His Leu Gly Glu Lys Leu Ser Thr Ser Trp Asp Pro Glu Ala 25 30 35 gaa cgg ggg tct gtt gtc ttg gtg gga aag ggc cca gac cac gaa gac 259 Glu Arg Gly Ser Val Val Leu Val Gly Lys Gly Pro Asp His Glu Asp 40 45 50 cag cgg ttt gct ttt gat gga tct gct acc tgt gat ctg gtt gcc ggc 307 Gln Arg Phe Ala Phe Asp Gly Ser Ala Thr Cys Asp Leu Val Ala Gly 55 60 65 gac ggc gtg ctg ttg ctc cac att gaa tcg ccc gcc agc ctg gtt gag 355 Asp Gly Val Leu Leu Leu His Ile Glu Ser Pro Ala Ser Leu Val Glu 70 75 80 85 cgt ttt gaa aat gtc atc ggc ggc cat ctg gtc ggc ttc gct cgg cgc 403 Arg Phe Glu Asn Val Ile Gly Gly His Leu Val Gly Phe Ala Arg Arg 90 95 100 gac gag atg aag att gct ttt cga cgt ggt gat gga tca gaa ggg ctg 451 Asp Glu Met Lys Ile Ala Phe Arg Arg Gly Asp Gly Ser Glu Gly Leu 105 110 115 tct ttt gag tcc gtc taacataatc cgcatcgcag ctgttctaat 496 Ser Phe Glu Ser Val 120 <210> 366 <211> 122 <212> PRT <213> Corynebacterium glutamicum <400> 366 Met Ile Val Thr Ser Thr Ala Arg Val Ser Ile Asp Arg Pro Ser Arg 1 5 10 15 Tyr Ala Lys Gln Leu Thr Ser His Leu Gly Glu Lys Leu Ser Thr Ser 20 25 30 Trp Asp Pro Glu Ala Glu Arg Gly Ser Val Val Leu Val Gly Lys Gly 35 40 45 Pro Asp His Glu Asp Gln Arg Phe Ala Phe Asp Gly Ser Ala Thr Cys 50 55 60 Asp Leu Val Ala Gly Asp Gly Val Leu Leu Leu His Ile Glu Ser Pro 65 70 75 80 Ala Ser Leu Val Glu Arg Phe Glu Asn Val Ile Gly Gly His Leu Val 85 90 95 Gly Phe Ala Arg Arg Asp Glu Met Lys Ile Ala Phe Arg Arg Gly Asp 100 105 110 Gly Ser Glu Gly Leu Ser Phe Glu Ser Val 115 120 <210> 367 <211> 757 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(727) <223> RXA03523 <400> 367 tctgtaattg cggtaattcg cttagttgaa gctgttgaaa ttacgagcac ttctaaatac 60 ctggtagatg gattatttag ccccggaagg ggctattttt gtg tct aaa ccc gag 115 Val Ser Lys Pro Glu 1 5 ggt aat ttg gga gga gcg tta agt act act gac agg tta aac aaa ggt 163 Gly Asn Leu Gly Gly Ala Leu Ser Thr Thr Asp Arg Leu Asn Lys Gly 10 15 20 ttt gcc agg tgt cgg gac ccg ctc gaa gct gaa aat gtc tac tgg gaa 211 Phe Ala Arg Cys Arg Asp Pro Leu Glu Ala Glu Asn Val Tyr Trp Glu 25 30 35 tac cgc aac aat gga gtc tgg atc agg att aac acc gac aac aac ttc 259 Tyr Arg Asn Asn Gly Val Trp Ile Arg Ile Asn Thr Asp Asn Asn Phe 40 45 50 cag gtc act acg gca gat gga ctc acc tcc tta acc gtg act gat acg 307 Gln Val Thr Thr Ala Asp Gly Leu Thr Ser Leu Thr Val Thr Asp Thr 55 60 65 gca gtt gat cag tct gga gca agg tta tgt gcc gtt gct act aat gct 355 Ala Val Asp Gln Ser Gly Ala Arg Leu Cys Ala Val Ala Thr Asn Ala 70 75 80 85 tct ggc ccc acg atg tcg agg gaa gct gtt ctc acg gtg cgt tct gca 403 Ser Gly Pro Thr Met Ser Arg Glu Ala Val Leu Thr Val Arg Ser Ala 90 95 100 acc gag atc cct gat gat ggt ctg agc att gat gat gtt gta ctg cgt 451 Thr Glu Ile Pro Asp Asp Gly Leu Ser Ile Asp Asp Val Val Leu Arg 105 110 115 tgg ggt att agt gag gaa gta caa tca cga cca cta ttt ggt gac tcc 499 Trp Gly Ile Ser Glu Glu Val Gln Ser Arg Pro Leu Phe Gly Asp Ser 120 125 130 aac tac cta tcc gct ggt gtg tct gat gga tct gca ttg acc tac gag 547 Asn Tyr Leu Ser Ala Gly Val Ser Asp Gly Ser Ala Leu Thr Tyr Glu 135 140 145 tca act gat agg gat gta cgc atc atc cac agg gtg ctg ttg caa agt 595 Ser Thr Asp Arg Asp Val Arg Ile Ile His Arg Val Leu Leu Gln Ser 150 155 160 165 tgg gcc agg gtc gaa aag ccc aac ctc aag aca tta gtt gtc ctt gct 643 Trp Ala Arg Val Glu Lys Pro Asn Leu Lys Thr Leu Val Val Leu Ala 170 175 180 ccg ggg tgc tta agc tgt ctc gaa tat ccg gct gac gat cac cgc gtc 691 Pro Gly Cys Leu Ser Cys Leu Glu Tyr Pro Ala Asp Asp His Arg Val 185 190 195 tgg gtt cgg gtg ccc gtg agg tca aac atc gtt ccc tgaccctttc 737 Trp Val Arg Val Pro Val Arg Ser Asn Ile Val Pro 200 205 cgcaatgaat gcatcgcctc 757 <210> 368 <211> 209 <212> PRT <213> Corynebacterium glutamicum <400> 368 Val Ser Lys Pro Glu Gly Asn Leu Gly Gly Ala Leu Ser Thr Thr Asp 1 5 10 15 Arg Leu Asn Lys Gly Phe Ala Arg Cys Arg Asp Pro Leu Glu Ala Glu 20 25 30 Asn Val Tyr Trp Glu Tyr Arg Asn Asn Gly Val Trp Ile Arg Ile Asn 35 40 45 Thr Asp Asn Asn Phe Gln Val Thr Thr Ala Asp Gly Leu Thr Ser Leu 50 55 60 Thr Val Thr Asp Thr Ala Val Asp Gln Ser Gly Ala Arg Leu Cys Ala 65 70 75 80 Val Ala Thr Asn Ala Ser Gly Pro Thr Met Ser Arg Glu Ala Val Leu 85 90 95 Thr Val Arg Ser Ala Thr Glu Ile Pro Asp Asp Gly Leu Ser Ile Asp 100 105 110 Asp Val Val Leu Arg Trp Gly Ile Ser Glu Glu Val Gln Ser Arg Pro 115 120 125 Leu Phe Gly Asp Ser Asn Tyr Leu Ser Ala Gly Val Ser Asp Gly Ser 130 135 140 Ala Leu Thr Tyr Glu Ser Thr Asp Arg Asp Val Arg Ile Ile His Arg 145 150 155 160 Val Leu Leu Gln Ser Trp Ala Arg Val Glu Lys Pro Asn Leu Lys Thr 165 170 175 Leu Val Val Leu Ala Pro Gly Cys Leu Ser Cys Leu Glu Tyr Pro Ala 180 185 190 Asp Asp His Arg Val Trp Val Arg Val Pro Val Arg Ser Asn Ile Val 195 200 205 Pro <210> 369 <211> 559 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(529) <223> RXA03572 <400> 369 accttggtgc actgcagggg ttgttttcta tgtgccaacg agttcttaag aaacacaacg 60 acagcaaagc tgcgttcggg agcatgtgtg aaccctcgct gtg ccc gca ctt gcc 115 Val Pro Ala Leu Ala 1 5 tgc ata cag ctc act caa caa cac aga aag aac ctt tta cca tgc tca 163 Cys Ile Gln Leu Thr Gln Gln His Arg Lys Asn Leu Leu Pro Cys Ser 10 15 20 atg cac tca acg ctg tcc ttg atg ttg tcg aat ctg ctc aag ggc tgg 211 Met His Ser Thr Leu Ser Leu Met Leu Ser Asn Leu Leu Lys Gly Trp 25 30 35 tct ttg tcg tca tca ctg cta gcc tgc tca ctc ttg ctg tca tct aca 259 Ser Leu Ser Ser Ser Leu Leu Ala Cys Ser Leu Leu Leu Ser Ser Thr 40 45 50 tca aga act atc ccc acg cgc cac agc ctg cta ccc aac aca cca ctg 307 Ser Arg Thr Ile Pro Thr Arg His Ser Leu Leu Pro Asn Thr Pro Leu 55 60 65 acc aac caa ctg tgc cag agc cgc tgc aga ttc ttg aca acc ctg ctc 355 Thr Asn Gln Leu Cys Gln Ser Arg Cys Arg Phe Leu Thr Thr Leu Leu 70 75 80 85 aga caa ctg ctg ctg gtc tac gcc atg acc ttc ata gcg atc tct acg 403 Arg Gln Leu Leu Leu Val Tyr Ala Met Thr Phe Ile Ala Ile Ser Thr 90 95 100 ccg aag aaa aga gcg cat aat ctg tgt ctc gat gtt gcc tgg gat gct 451 Pro Lys Lys Arg Ala His Asn Leu Cys Leu Asp Val Ala Trp Asp Ala 105 110 115 gat gaa aac ctc cct gtt gtc gtt gaa gtc aat cct gta gcg atg cct 499 Asp Glu Asn Leu Pro Val Val Val Glu Val Asn Pro Val Ala Met Pro 120 125 130 ggg tgt tgc gcc tcg ggc gca gct ggg tgc taacttagca ccgcatcaac 549 Gly Cys Cys Ala Ser Gly Ala Ala Gly Cys 135 140 gcagcgaagc 559 <210> 370 <211> 143 <212> PRT <213> Corynebacterium glutamicum <400> 370 Val Pro Ala Leu Ala Cys Ile Gln Leu Thr Gln Gln His Arg Lys Asn 1 5 10 15 Leu Leu Pro Cys Ser Met His Ser Thr Leu Ser Leu Met Leu Ser Asn 20 25 30 Leu Leu Lys Gly Trp Ser Leu Ser Ser Ser Leu Leu Ala Cys Ser Leu 35 40 45 Leu Leu Ser Ser Thr Ser Arg Thr Ile Pro Thr Arg His Ser Leu Leu 50 55 60 Pro Asn Thr Pro Leu Thr Asn Gln Leu Cys Gln Ser Arg Cys Arg Phe 65 70 75 80 Leu Thr Thr Leu Leu Arg Gln Leu Leu Leu Val Tyr Ala Met Thr Phe 85 90 95 Ile Ala Ile Ser Thr Pro Lys Lys Arg Ala His Asn Leu Cys Leu Asp 100 105 110 Val Ala Trp Asp Ala Asp Glu Asn Leu Pro Val Val Val Glu Val Asn 115 120 125 Pro Val Ala Met Pro Gly Cys Cys Ala Ser Gly Ala Ala Gly Cys 130 135 140 <210> 371 <211> 505 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(475) <223> RXA03577 <400> 371 aattttgcaa gcgttccgag gcggccttgc aacgtcttac cccaaatata atcaaattag 60 agacctagtc gactcaagta gttaagagga aacaacaata atg tta cga aaa gta 115 Met Leu Arg Lys Val 1 5 tcc att gca ttg gtc gca tcc gcc gct atc ttg gta tct gta cct ttc 163 Ser Ile Ala Leu Val Ala Ser Ala Ala Ile Leu Val Ser Val Pro Phe 10 15 20 gca cag gca tcg acc tca gtg gca ctg tcg tca gaa agc tca gat tct 211 Ala Gln Ala Ser Thr Ser Val Ala Leu Ser Ser Glu Ser Ser Asp Ser 25 30 35 ctg gga agt att cca aac gat tta att ggg ggt cta gcc ggt tac ttt 259 Leu Gly Ser Ile Pro Asn Asp Leu Ile Gly Gly Leu Ala Gly Tyr Phe 40 45 50 aat aaa gat ctt acg gag gaa cag cgc gat gct att cgc ttc ggc ccc 307 Asn Lys Asp Leu Thr Glu Glu Gln Arg Asp Ala Ile Arg Phe Gly Pro 55 60 65 acc aca gca caa gaa gca gaa cag tgc tta gca aaa tac gga ctt ggc 355 Thr Thr Ala Gln Glu Ala Glu Gln Cys Leu Ala Lys Tyr Gly Leu Gly 70 75 80 85 ggt gaa ggc ccg tgg cct act atc gcg gtg tac cct aac tgc tct ttc 403 Gly Glu Gly Pro Trp Pro Thr Ile Ala Val Tyr Pro Asn Cys Ser Phe 90 95 100 gag aca att gaa caa gat ttc tat gat caa gcg gta gcc gag act ctc 451 Glu Thr Ile Glu Gln Asp Phe Tyr Asp Gln Ala Val Ala Glu Thr Leu 105 110 115 gca gca ata ggc atc ggg agc tct taaacaatca aaggtacaac ccaaaaaaca 505 Ala Ala Ile Gly Ile Gly Ser Ser 120 125 <210> 372 <211> 125 <212> PRT <213> Corynebacterium glutamicum <400> 372 Met Leu Arg Lys Val Ser Ile Ala Leu Val Ala Ser Ala Ala Ile Leu 1 5 10 15 Val Ser Val Pro Phe Ala Gln Ala Ser Thr Ser Val Ala Leu Ser Ser 20 25 30 Glu Ser Ser Asp Ser Leu Gly Ser Ile Pro Asn Asp Leu Ile Gly Gly 35 40 45 Leu Ala Gly Tyr Phe Asn Lys Asp Leu Thr Glu Glu Gln Arg Asp Ala 50 55 60 Ile Arg Phe Gly Pro Thr Thr Ala Gln Glu Ala Glu Gln Cys Leu Ala 65 70 75 80 Lys Tyr Gly Leu Gly Gly Glu Gly Pro Trp Pro Thr Ile Ala Val Tyr 85 90 95 Pro Asn Cys Ser Phe Glu Thr Ile Glu Gln Asp Phe Tyr Asp Gln Ala 100 105 110 Val Ala Glu Thr Leu Ala Ala Ile Gly Ile Gly Ser Ser 115 120 125 <210> 373 <211> 379 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(349) <223> RXA03584 <400> 373 gcacatcatt tagacctgat ctgtctcact tgtggtcact ccccgtaggg tgggtagctc 60 cggggcttga gggtttcgtg gagcgtaatt cagaggcagc ttg aac cac cgc tct 115 Leu Asn His Arg Ser 1 5 ttg agc cgg aat ctc cac tct tta ggg tgg aga gga tat caa aag atg 163 Leu Ser Arg Asn Leu His Ser Leu Gly Trp Arg Gly Tyr Gln Lys Met 10 15 20 gga gat cat ggt cga aaa agt gag ttc gca gga atc tcc cgg agg aag 211 Gly Asp His Gly Arg Lys Ser Glu Phe Ala Gly Ile Ser Arg Arg Lys 25 30 35 tcg cac cgg ctt atc acg tcg att tat ggg gct tgt tgc cgg cag gag 259 Ser His Arg Leu Ile Thr Ser Ile Tyr Gly Ala Cys Cys Arg Gln Glu 40 45 50 tca ctg tat ggg ttt gca tgt aaa agt aaa aaa ata acc ccc gca gca 307 Ser Leu Tyr Gly Phe Ala Cys Lys Ser Lys Lys Ile Thr Pro Ala Ala 55 60 65 gct tgt tta agc tac tac gag ggt tat ttt ttg tgg atg tgt 349 Ala Cys Leu Ser Tyr Tyr Glu Gly Tyr Phe Leu Trp Met Cys 70 75 80 tagtcaaatg gcgcgagttc ccatactgca 379 <210> 374 <211> 83 <212> PRT <213> Corynebacterium glutamicum <400> 374 Leu Asn His Arg Ser Leu Ser Arg Asn Leu His Ser Leu Gly Trp Arg 1 5 10 15 Gly Tyr Gln Lys Met Gly Asp His Gly Arg Lys Ser Glu Phe Ala Gly 20 25 30 Ile Ser Arg Arg Lys Ser His Arg Leu Ile Thr Ser Ile Tyr Gly Ala 35 40 45 Cys Cys Arg Gln Glu Ser Leu Tyr Gly Phe Ala Cys Lys Ser Lys Lys 50 55 60 Ile Thr Pro Ala Ala Ala Cys Leu Ser Tyr Tyr Glu Gly Tyr Phe Leu 65 70 75 80 Trp Met Cys <210> 375 <211> 3919 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3889) <223> RXA03591 <400> 375 aggactgctc cgcaaacctc taacaacacc tgctactccc cctgcagcgc cgctcaaccc 60 cacaccaccc accccttaac aaccacaaga aagatttatc atg tcc gct cca acc 115 Met Ser Ala Pro Thr 1 5 atc tac ccc ggc acc aaa aca tct att gat ccg atc acc atg gat gac 163 Ile Tyr Pro Gly Thr Lys Thr Ser Ile Asp Pro Ile Thr Met Asp Asp 10 15 20 gct cgc atc atc ttt ttc gat att gag tcg ctc cac aat att ttc acg 211 Ala Arg Ile Ile Phe Phe Asp Ile Glu Ser Leu His Asn Ile Phe Thr 25 30 35 gta gca acc tac gat tct ctg tcc cac cac gtc gat gtc ttt tac ctg 259 Val Ala Thr Tyr Asp Ser Leu Ser His His Val Asp Val Phe Tyr Leu 40 45 50 ctc gat cac aca acc agc cct cag atc acg gtg ctg ccg cac tca atg 307 Leu Asp His Thr Thr Ser Pro Gln Ile Thr Val Leu Pro His Ser Met 55 60 65 gat tat ttc gat caa acg cgc agc gat gct gtt atg gct gcc atc att 355 Asp Tyr Phe Asp Gln Thr Arg Ser Asp Ala Val Met Ala Ala Ile Ile 70 75 80 85 gag caa aac cct gcg ttc gca gaa att aaa ggc tca ccc att aca acc 403 Glu Gln Asn Pro Ala Phe Ala Glu Ile Lys Gly Ser Pro Ile Thr Thr 90 95 100 gca gat gta gcc ctc cac aat ctc ggt gac acc aac gcc aac cga cgc 451 Ala Asp Val Ala Leu His Asn Leu Gly Asp Thr Asn Ala Asn Arg Arg 105 110 115 tgg cag tct aac gtg ctg ctt gcc cgg cta ctc ggg ggt att agt gtg 499 Trp Gln Ser Asn Val Leu Leu Ala Arg Leu Leu Gly Gly Ile Ser Val 120 125 130 cgc gga gag gta cct gag cac cag agc cac aac cat ctc gcc aag cag 547 Arg Gly Glu Val Pro Glu His Gln Ser His Asn His Leu Ala Lys Gln 135 140 145 ttt gcc gag gca acc ttg gtc acc agg gac ttc gat gtg aat tat gat 595 Phe Ala Glu Ala Thr Leu Val Thr Arg Asp Phe Asp Val Asn Tyr Asp 150 155 160 165 cca aca agc gct cac cct ttt act gct ggc ttc aac tcg atc aac tat 643 Pro Thr Ser Ala His Pro Phe Thr Ala Gly Phe Asn Ser Ile Asn Tyr 170 175 180 gac acc acc ttg ctc agc ctg tac ttc gca atg ttg acc tca aat atc 691 Asp Thr Thr Leu Leu Ser Leu Tyr Phe Ala Met Leu Thr Ser Asn Ile 185 190 195 gga agt aca ccg acg tat ttc ccg gtg atc acc gca cag gaa ctt cgt 739 Gly Ser Thr Pro Thr Tyr Phe Pro Val Ile Thr Ala Gln Glu Leu Arg 200 205 210 gcg cat aac gac aag ctc ttt agc cct gag ttc atc aaa aac atg cca 787 Ala His Asn Asp Lys Leu Phe Ser Pro Glu Phe Ile Lys Asn Met Pro 215 220 225 aag tat ctc tgg gat cgc gac agc ggt gct gga ctc aga gct gca tcg 835 Lys Tyr Leu Trp Asp Arg Asp Ser Gly Ala Gly Leu Arg Ala Ala Ser 230 235 240 245 ggt ttc cgc aac gcc atg ctc aaa tcg ggt cgc cac att gat att caa 883 Gly Phe Arg Asn Ala Met Leu Lys Ser Gly Arg His Ile Asp Ile Gln 250 255 260 cgc ctc aat gaa aaa cag ctc ttt gtt gga ctc aag cgc ctg ctt ggt 931 Arg Leu Asn Glu Lys Gln Leu Phe Val Gly Leu Lys Arg Leu Leu Gly 265 270 275 ctc ctc ggt cac cag att ctc gaa tct gat cgt ctc tct ggt gat gat 979 Leu Leu Gly His Gln Ile Leu Glu Ser Asp Arg Leu Ser Gly Asp Asp 280 285 290 gcc cat gtt gat act aac gag gat gta ctt gat ctc att gcc tac aac 1027 Ala His Val Asp Thr Asn Glu Asp Val Leu Asp Leu Ile Ala Tyr Asn 295 300 305 gtc tca gac gtg gtg ggc acc aga ctg ctc gct gag gac ccg gtg tac 1075 Val Ser Asp Val Val Gly Thr Arg Leu Leu Ala Glu Asp Pro Val Tyr 310 315 320 325 tcc ggc tct ttc gat ctg cgg gca ggt cta ctg agc acc tac cca gag 1123 Ser Gly Ser Phe Asp Leu Arg Ala Gly Leu Leu Ser Thr Tyr Pro Glu 330 335 340 act gtt ttt gat cat gat ggt act ttc cgt cag cca tcc acg cag atg 1171 Thr Val Phe Asp His Asp Gly Thr Phe Arg Gln Pro Ser Thr Gln Met 345 350 355 cgt aaa gat cgc cta acg att aat acc tca tca gct cag ttc gca gcg 1219 Arg Lys Asp Arg Leu Thr Ile Asn Thr Ser Ser Ala Gln Phe Ala Ala 360 365 370 cgt att ttg gcg cca tat cgc cca ctc cgc gat gtc cct gat gcg att 1267 Arg Ile Leu Ala Pro Tyr Arg Pro Leu Arg Asp Val Pro Asp Ala Ile 375 380 385 ggc gac atg ccg gtg gtg tct tac ttg tac ccg gat gca gca gtc gcc 1315 Gly Asp Met Pro Val Val Ser Tyr Leu Tyr Pro Asp Ala Ala Val Ala 390 395 400 405 gaa gca aca ggt caa aaa caa gtc aac gtg ctt gat gag tca aag aag 1363 Glu Ala Thr Gly Gln Lys Gln Val Asn Val Leu Asp Glu Ser Lys Lys 410 415 420 ttc ttc tat gac aac atc acc gac ccg gaa gca cgt gct gcc ttt gat 1411 Phe Phe Tyr Asp Asn Ile Thr Asp Pro Glu Ala Arg Ala Ala Phe Asp 425 430 435 gag gtc ttt gct ttt tac gct gat att gag ggt cgc aac ttc aac agt 1459 Glu Val Phe Ala Phe Tyr Ala Asp Ile Glu Gly Arg Asn Phe Asn Ser 440 445 450 cac aat gag gct att gat acc cag att aac caa tta cgt gct tat ctc 1507 His Asn Glu Ala Ile Asp Thr Gln Ile Asn Gln Leu Arg Ala Tyr Leu 455 460 465 aac cag gtt gtc gca ttc gat gca gct ggg tat gcg ctc tat gat gta 1555 Asn Gln Val Val Ala Phe Asp Ala Ala Gly Tyr Ala Leu Tyr Asp Val 470 475 480 485 cgt aca cgt ttt gag cag atc ttc ccc aag gat cgc agc tac atc aac 1603 Arg Thr Arg Phe Glu Gln Ile Phe Pro Lys Asp Arg Ser Tyr Ile Asn 490 495 500 gat gct acg gat atg acc cct cgc gca gta tcg agc ttt gac gat ctg 1651 Asp Ala Thr Asp Met Thr Pro Arg Ala Val Ser Ser Phe Asp Asp Leu 505 510 515 gtt gca ctc tgt gat gat att cgc ggt gta ctt gat cga ggt tta gag 1699 Val Ala Leu Cys Asp Asp Ile Arg Gly Val Leu Asp Arg Gly Leu Glu 520 525 530 atc tca tct ccg aat cat cat gag atg gtg gat gct atg cgc aag cag 1747 Ile Ser Ser Pro Asn His His Glu Met Val Asp Ala Met Arg Lys Gln 535 540 545 ctg cac tat att cag gca ttt tac cgt gcc tgg gga ccc att caa cgc 1795 Leu His Tyr Ile Gln Ala Phe Tyr Arg Ala Trp Gly Pro Ile Gln Arg 550 555 560 565 cgc ttc aat gac gct gac cca gcg gtg acc cat ccg cat ctc aca gtg 1843 Arg Phe Asn Asp Ala Asp Pro Ala Val Thr His Pro His Leu Thr Val 570 575 580 atc tac cca ccg ctc acc cct gca tcc gca gag aaa ttc aac aag atc 1891 Ile Tyr Pro Pro Leu Thr Pro Ala Ser Ala Glu Lys Phe Asn Lys Ile 585 590 595 acc tca gtc gct gct gtg agc aag cgc cca acc acc ctg ccg tat ttc 1939 Thr Ser Val Ala Ala Val Ser Lys Arg Pro Thr Thr Leu Pro Tyr Phe 600 605 610 cgt gca gat ggt tca cct act cgt ggc ttt gct aac ttc tcc aca gga 1987 Arg Ala Asp Gly Ser Pro Thr Arg Gly Phe Ala Asn Phe Ser Thr Gly 615 620 625 ggt att cac ggt gcg gaa tac aac gaa gat cgt ttt gac cat gat caa 2035 Gly Ile His Gly Ala Glu Tyr Asn Glu Asp Arg Phe Asp His Asp Gln 630 635 640 645 gat cta cac aca gtg gca acc cgt gaa ttc ttc gcc att ctt gat gcg 2083 Asp Leu His Thr Val Ala Thr Arg Glu Phe Phe Ala Ile Leu Asp Ala 650 655 660 aca tta gcg gct ctc tac gca gcc cac caa gcc gaa cct gaa tcg gcg 2131 Thr Leu Ala Ala Leu Tyr Ala Ala His Gln Ala Glu Pro Glu Ser Ala 665 670 675 gac tac cag att gca caa gac gca ctc gcc tgg gca aag aat gta ctt 2179 Asp Tyr Gln Ile Ala Gln Asp Ala Leu Ala Trp Ala Lys Asn Val Leu 680 685 690 agc gat caa aaa ctc atc gct aag tcg cct cag tta tac aac ccc gaa 2227 Ser Asp Gln Lys Leu Ile Ala Lys Ser Pro Gln Leu Tyr Asn Pro Glu 695 700 705 acc ggg gtc acc tat gag tgg gag ttt gtc gct caa gca gca tgg tgg 2275 Thr Gly Val Thr Tyr Glu Trp Glu Phe Val Ala Gln Ala Ala Trp Trp 710 715 720 725 att cgc aac aaa ccg gtt gag gtt att tta cca aca ggt gaa tca atg 2323 Ile Arg Asn Lys Pro Val Glu Val Ile Leu Pro Thr Gly Glu Ser Met 730 735 740 acc gta aaa cac aaa tct gta ttg gca tct gcg tcc tac cca ctc cga 2371 Thr Val Lys His Lys Ser Val Leu Ala Ser Ala Ser Tyr Pro Leu Arg 745 750 755 gac aac gtg gcg tac tgg cgt agc gaa ccc aaa aca cca cag ctg ttt 2419 Asp Asn Val Ala Tyr Trp Arg Ser Glu Pro Lys Thr Pro Gln Leu Phe 760 765 770 ccc gta gca aaa tct ggt ggt tcc tcg ctt gag aag aag tac aac tac 2467 Pro Val Ala Lys Ser Gly Gly Ser Ser Leu Glu Lys Lys Tyr Asn Tyr 775 780 785 acc tct gtg ggt act gct att cac gag gac ttt agc agt tac tat ccg 2515 Thr Ser Val Gly Thr Ala Ile His Glu Asp Phe Ser Ser Tyr Tyr Pro 790 795 800 805 ctc ttg ctc acc aat atg gct gca ttt acc aat gct gac tta ggt att 2563 Leu Leu Leu Thr Asn Met Ala Ala Phe Thr Asn Ala Asp Leu Gly Ile 810 815 820 gat gag aaa acc ggg cgc cct cgt gac cgc tac cgt gaa atc tac gaa 2611 Asp Glu Lys Thr Gly Arg Pro Arg Asp Arg Tyr Arg Glu Ile Tyr Glu 825 830 835 caa aaa gag atc tat ggc gca cag cgc aaa gac ccc tcc att gat gaa 2659 Gln Lys Glu Ile Tyr Gly Ala Gln Arg Lys Asp Pro Ser Ile Asp Glu 840 845 850 gaa aca aag caa cgt cta ggg att ttg cgc gaa ggt acc aag ttg att 2707 Glu Thr Lys Gln Arg Leu Gly Ile Leu Arg Glu Gly Thr Lys Leu Ile 855 860 865 ctt aac tcg gcc acc ggt gct gct gat gct ggt cac gac acc ccg atc 2755 Leu Asn Ser Ala Thr Gly Ala Ala Asp Ala Gly His Asp Thr Pro Ile 870 875 880 885 ctc atg aac aat cgc gtt att gcc atg agg att att ggg cag cta ttt 2803 Leu Met Asn Asn Arg Val Ile Ala Met Arg Ile Ile Gly Gln Leu Phe 890 895 900 tct tgg aga att ggg caa gct caa tca ctg gct ggt gca acg att att 2851 Ser Trp Arg Ile Gly Gln Ala Gln Ser Leu Ala Gly Ala Thr Ile Ile 905 910 915 tcc act aac act gat ggc ctg tat tcc gta ctc gat atg ggg act aac 2899 Ser Thr Asn Thr Asp Gly Leu Tyr Ser Val Leu Asp Met Gly Thr Asn 920 925 930 cag cgc gtt ctt gat gaa cac gct aca gcc atc ggt gtg caa att gag 2947 Gln Arg Val Leu Asp Glu His Ala Thr Ala Ile Gly Val Gln Ile Glu 935 940 945 cct gaa gaa ctg gat att gtc tcc aag gat tcc aac tca cgt gcc gaa 2995 Pro Glu Glu Leu Asp Ile Val Ser Lys Asp Ser Asn Ser Arg Ala Glu 950 955 960 965 ttt ctc ggc aat ggc tac atc aat gcg gcc ggt gac ttg gcg tgt tgg 3043 Phe Leu Gly Asn Gly Tyr Ile Asn Ala Ala Gly Asp Leu Ala Cys Trp 970 975 980 gat gga ccc aac tct cgg aac tca cta gat cac ccg gcc ttt gtt gac 3091 Asp Gly Pro Asn Ser Arg Asn Ser Leu Asp His Pro Ala Phe Val Asp 985 990 995 cat gtg ctg gtg aag tat ttc cag ctc gtc gtc aac aac act gtg cca 3139 His Val Leu Val Lys Tyr Phe Gln Leu Val Val Asn Asn Thr Val Pro 1000 1005 1010 gag att cca gaa aca cct gag ctt gag ggt gta ccg ctg gct ctt gat 3187 Glu Ile Pro Glu Thr Pro Glu Leu Glu Gly Val Pro Leu Ala Leu Asp 1015 1020 1025 caa ccc atg aac cgc cac gaa gtc tcg aag att gtc gcc act atg cac 3235 Gln Pro Met Asn Arg His Glu Val Ser Lys Ile Val Ala Thr Met His 1030 1035 1040 1045 aag gaa ttc gag ccg aaa aag ctg ctg tcg ttt tac caa aac att ttg 3283 Lys Glu Phe Glu Pro Lys Lys Leu Leu Ser Phe Tyr Gln Asn Ile Leu 1050 1055 1060 gcc tct tca cgc ggt tct aat acc ttc cta ttc tct gtc ccc tat atc 3331 Ala Ser Ser Arg Gly Ser Asn Thr Phe Leu Phe Ser Val Pro Tyr Ile 1065 1070 1075 cct gca aca gaa gga gaa gaa acc cac cct gca aca gat acc agc act 3379 Pro Ala Thr Glu Gly Glu Glu Thr His Pro Ala Thr Asp Thr Ser Thr 1080 1085 1090 att gcg aca cca acc ttg agc ttt gat gct tat ggt aat aag gcc gag 3427 Ile Ala Thr Pro Thr Leu Ser Phe Asp Ala Tyr Gly Asn Lys Ala Glu 1095 1100 1105 gtc atg ccg act caa tcc act gtg gat aag cgc gtg ccc tct ttg ctg 3475 Val Met Pro Thr Gln Ser Thr Val Asp Lys Arg Val Pro Ser Leu Leu 1110 1115 1120 1125 cag tat tac acg cgt aca ttc cat gtg cga caa gat acg cag cag gct 3523 Gln Tyr Tyr Thr Arg Thr Phe His Val Arg Gln Asp Thr Gln Gln Ala 1130 1135 1140 gtc ttt gat gtt att ggc gcc aac ccc gtg ctc atc gcc gca gca aaa 3571 Val Phe Asp Val Ile Gly Ala Asn Pro Val Leu Ile Ala Ala Ala Lys 1145 1150 1155 gct gca tcc ata tca ccg gct tct gct gat tca cgt aga aag aag ggc 3619 Ala Ala Ser Ile Ser Pro Ala Ser Ala Asp Ser Arg Arg Lys Lys Gly 1160 1165 1170 ctg gcc tcc acc aac gct gac cca gta gcc aag cat gta cta gaa att 3667 Leu Ala Ser Thr Asn Ala Asp Pro Val Ala Lys His Val Leu Glu Ile 1175 1180 1185 gca gga gct gat gtg gaa tcg ctg cgc cat gaa aag gat ctc aag gtc 3715 Ala Gly Ala Asp Val Glu Ser Leu Arg His Glu Lys Asp Leu Lys Val 1190 1195 1200 1205 acc aag cac act ggc caa gac cca gca ctg cct gtc gtg gtc ttt aac 3763 Thr Lys His Thr Gly Gln Asp Pro Ala Leu Pro Val Val Val Phe Asn 1210 1215 1220 caa acc att tgg cat aac ccc aac gac gat gtg att aat gca tta ctg 3811 Gln Thr Ile Trp His Asn Pro Asn Asp Asp Val Ile Asn Ala Leu Leu 1225 1230 1235 ggc gct att gac cag gat gcc tac att gac atg gcg atc tcg tcc tac 3859 Gly Ala Ile Asp Gln Asp Ala Tyr Ile Asp Met Ala Ile Ser Ser Tyr 1240 1245 1250 aac aag tcc tgg cac aac att atc ccg gct taactaccgc tgggtagacc 3909 Asn Lys Ser Trp His Asn Ile Ile Pro Ala 1255 1260 ccttgatgac 3919 <210> 376 <211> 1263 <212> PRT <213> Corynebacterium glutamicum <400> 376 Met Ser Ala Pro Thr Ile Tyr Pro Gly Thr Lys Thr Ser Ile Asp Pro 1 5 10 15 Ile Thr Met Asp Asp Ala Arg Ile Ile Phe Phe Asp Ile Glu Ser Leu 20 25 30 His Asn Ile Phe Thr Val Ala Thr Tyr Asp Ser Leu Ser His His Val 35 40 45 Asp Val Phe Tyr Leu Leu Asp His Thr Thr Ser Pro Gln Ile Thr Val 50 55 60 Leu Pro His Ser Met Asp Tyr Phe Asp Gln Thr Arg Ser Asp Ala Val 65 70 75 80 Met Ala Ala Ile Ile Glu Gln Asn Pro Ala Phe Ala Glu Ile Lys Gly 85 90 95 Ser Pro Ile Thr Thr Ala Asp Val Ala Leu His Asn Leu Gly Asp Thr 100 105 110 Asn Ala Asn Arg Arg Trp Gln Ser Asn Val Leu Leu Ala Arg Leu Leu 115 120 125 Gly Gly Ile Ser Val Arg Gly Glu Val Pro Glu His Gln Ser His Asn 130 135 140 His Leu Ala Lys Gln Phe Ala Glu Ala Thr Leu Val Thr Arg Asp Phe 145 150 155 160 Asp Val Asn Tyr Asp Pro Thr Ser Ala His Pro Phe Thr Ala Gly Phe 165 170 175 Asn Ser Ile Asn Tyr Asp Thr Thr Leu Leu Ser Leu Tyr Phe Ala Met 180 185 190 Leu Thr Ser Asn Ile Gly Ser Thr Pro Thr Tyr Phe Pro Val Ile Thr 195 200 205 Ala Gln Glu Leu Arg Ala His Asn Asp Lys Leu Phe Ser Pro Glu Phe 210 215 220 Ile Lys Asn Met Pro Lys Tyr Leu Trp Asp Arg Asp Ser Gly Ala Gly 225 230 235 240 Leu Arg Ala Ala Ser Gly Phe Arg Asn Ala Met Leu Lys Ser Gly Arg 245 250 255 His Ile Asp Ile Gln Arg Leu Asn Glu Lys Gln Leu Phe Val Gly Leu 260 265 270 Lys Arg Leu Leu Gly Leu Leu Gly His Gln Ile Leu Glu Ser Asp Arg 275 280 285 Leu Ser Gly Asp Asp Ala His Val Asp Thr Asn Glu Asp Val Leu Asp 290 295 300 Leu Ile Ala Tyr Asn Val Ser Asp Val Val Gly Thr Arg Leu Leu Ala 305 310 315 320 Glu Asp Pro Val Tyr Ser Gly Ser Phe Asp Leu Arg Ala Gly Leu Leu 325 330 335 Ser Thr Tyr Pro Glu Thr Val Phe Asp His Asp Gly Thr Phe Arg Gln 340 345 350 Pro Ser Thr Gln Met Arg Lys Asp Arg Leu Thr Ile Asn Thr Ser Ser 355 360 365 Ala Gln Phe Ala Ala Arg Ile Leu Ala Pro Tyr Arg Pro Leu Arg Asp 370 375 380 Val Pro Asp Ala Ile Gly Asp Met Pro Val Val Ser Tyr Leu Tyr Pro 385 390 395 400 Asp Ala Ala Val Ala Glu Ala Thr Gly Gln Lys Gln Val Asn Val Leu 405 410 415 Asp Glu Ser Lys Lys Phe Phe Tyr Asp Asn Ile Thr Asp Pro Glu Ala 420 425 430 Arg Ala Ala Phe Asp Glu Val Phe Ala Phe Tyr Ala Asp Ile Glu Gly 435 440 445 Arg Asn Phe Asn Ser His Asn Glu Ala Ile Asp Thr Gln Ile Asn Gln 450 455 460 Leu Arg Ala Tyr Leu Asn Gln Val Val Ala Phe Asp Ala Ala Gly Tyr 465 470 475 480 Ala Leu Tyr Asp Val Arg Thr Arg Phe Glu Gln Ile Phe Pro Lys Asp 485 490 495 Arg Ser Tyr Ile Asn Asp Ala Thr Asp Met Thr Pro Arg Ala Val Ser 500 505 510 Ser Phe Asp Asp Leu Val Ala Leu Cys Asp Asp Ile Arg Gly Val Leu 515 520 525 Asp Arg Gly Leu Glu Ile Ser Ser Pro Asn His His Glu Met Val Asp 530 535 540 Ala Met Arg Lys Gln Leu His Tyr Ile Gln Ala Phe Tyr Arg Ala Trp 545 550 555 560 Gly Pro Ile Gln Arg Arg Phe Asn Asp Ala Asp Pro Ala Val Thr His 565 570 575 Pro His Leu Thr Val Ile Tyr Pro Pro Leu Thr Pro Ala Ser Ala Glu 580 585 590 Lys Phe Asn Lys Ile Thr Ser Val Ala Ala Val Ser Lys Arg Pro Thr 595 600 605 Thr Leu Pro Tyr Phe Arg Ala Asp Gly Ser Pro Thr Arg Gly Phe Ala 610 615 620 Asn Phe Ser Thr Gly Gly Ile His Gly Ala Glu Tyr Asn Glu Asp Arg 625 630 635 640 Phe Asp His Asp Gln Asp Leu His Thr Val Ala Thr Arg Glu Phe Phe 645 650 655 Ala Ile Leu Asp Ala Thr Leu Ala Ala Leu Tyr Ala Ala His Gln Ala 660 665 670 Glu Pro Glu Ser Ala Asp Tyr Gln Ile Ala Gln Asp Ala Leu Ala Trp 675 680 685 Ala Lys Asn Val Leu Ser Asp Gln Lys Leu Ile Ala Lys Ser Pro Gln 690 695 700 Leu Tyr Asn Pro Glu Thr Gly Val Thr Tyr Glu Trp Glu Phe Val Ala 705 710 715 720 Gln Ala Ala Trp Trp Ile Arg Asn Lys Pro Val Glu Val Ile Leu Pro 725 730 735 Thr Gly Glu Ser Met Thr Val Lys His Lys Ser Val Leu Ala Ser Ala 740 745 750 Ser Tyr Pro Leu Arg Asp Asn Val Ala Tyr Trp Arg Ser Glu Pro Lys 755 760 765 Thr Pro Gln Leu Phe Pro Val Ala Lys Ser Gly Gly Ser Ser Leu Glu 770 775 780 Lys Lys Tyr Asn Tyr Thr Ser Val Gly Thr Ala Ile His Glu Asp Phe 785 790 795 800 Ser Ser Tyr Tyr Pro Leu Leu Leu Thr Asn Met Ala Ala Phe Thr Asn 805 810 815 Ala Asp Leu Gly Ile Asp Glu Lys Thr Gly Arg Pro Arg Asp Arg Tyr 820 825 830 Arg Glu Ile Tyr Glu Gln Lys Glu Ile Tyr Gly Ala Gln Arg Lys Asp 835 840 845 Pro Ser Ile Asp Glu Glu Thr Lys Gln Arg Leu Gly Ile Leu Arg Glu 850 855 860 Gly Thr Lys Leu Ile Leu Asn Ser Ala Thr Gly Ala Ala Asp Ala Gly 865 870 875 880 His Asp Thr Pro Ile Leu Met Asn Asn Arg Val Ile Ala Met Arg Ile 885 890 895 Ile Gly Gln Leu Phe Ser Trp Arg Ile Gly Gln Ala Gln Ser Leu Ala 900 905 910 Gly Ala Thr Ile Ile Ser Thr Asn Thr Asp Gly Leu Tyr Ser Val Leu 915 920 925 Asp Met Gly Thr Asn Gln Arg Val Leu Asp Glu His Ala Thr Ala Ile 930 935 940 Gly Val Gln Ile Glu Pro Glu Glu Leu Asp Ile Val Ser Lys Asp Ser 945 950 955 960 Asn Ser Arg Ala Glu Phe Leu Gly Asn Gly Tyr Ile Asn Ala Ala Gly 965 970 975 Asp Leu Ala Cys Trp Asp Gly Pro Asn Ser Arg Asn Ser Leu Asp His 980 985 990 Pro Ala Phe Val Asp His Val Leu Val Lys Tyr Phe Gln Leu Val Val 995 1000 1005 Asn Asn Thr Val Pro Glu Ile Pro Glu Thr Pro Glu Leu Glu Gly Val 1010 1015 1020 Pro Leu Ala Leu Asp Gln Pro Met Asn Arg His Glu Val Ser Lys Ile 1025 1030 1035 1040 Val Ala Thr Met His Lys Glu Phe Glu Pro Lys Lys Leu Leu Ser Phe 1045 1050 1055 Tyr Gln Asn Ile Leu Ala Ser Ser Arg Gly Ser Asn Thr Phe Leu Phe 1060 1065 1070 Ser Val Pro Tyr Ile Pro Ala Thr Glu Gly Glu Glu Thr His Pro Ala 1075 1080 1085 Thr Asp Thr Ser Thr Ile Ala Thr Pro Thr Leu Ser Phe Asp Ala Tyr 1090 1095 1100 Gly Asn Lys Ala Glu Val Met Pro Thr Gln Ser Thr Val Asp Lys Arg 1105 1110 1115 1120 Val Pro Ser Leu Leu Gln Tyr Tyr Thr Arg Thr Phe His Val Arg Gln 1125 1130 1135 Asp Thr Gln Gln Ala Val Phe Asp Val Ile Gly Ala Asn Pro Val Leu 1140 1145 1150 Ile Ala Ala Ala Lys Ala Ala Ser Ile Ser Pro Ala Ser Ala Asp Ser 1155 1160 1165 Arg Arg Lys Lys Gly Leu Ala Ser Thr Asn Ala Asp Pro Val Ala Lys 1170 1175 1180 His Val Leu Glu Ile Ala Gly Ala Asp Val Glu Ser Leu Arg His Glu 1185 1190 1195 1200 Lys Asp Leu Lys Val Thr Lys His Thr Gly Gln Asp Pro Ala Leu Pro 1205 1210 1215 Val Val Val Phe Asn Gln Thr Ile Trp His Asn Pro Asn Asp Asp Val 1220 1225 1230 Ile Asn Ala Leu Leu Gly Ala Ile Asp Gln Asp Ala Tyr Ile Asp Met 1235 1240 1245 Ala Ile Ser Ser Tyr Asn Lys Ser Trp His Asn Ile Ile Pro Ala 1250 1255 1260 <210> 377 <211> 487 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(457) <223> RXA03613 <400> 377 gtatttagga attgaaaccc actaaaaaac agactaagtt actaggtgat aacaaaagtt 60 gtttattact tatgggaata gtgtggaaag tagggtgaat atg tca att cct gga 115 Met Ser Ile Pro Gly 1 5 aat gtt agt tat gtt gca cag ggt ggc acc ggt tgg gat ggt gct gat 163 Asn Val Ser Tyr Val Ala Gln Gly Gly Thr Gly Trp Asp Gly Ala Asp 10 15 20 cag tac acc acg ggt gag agt tgg gat cta cag tcg ttc ctt gaa aac 211 Gln Tyr Thr Thr Gly Glu Ser Trp Asp Leu Gln Ser Phe Leu Glu Asn 25 30 35 tcg act gac tac ctc atg att att ggt ggt tcg ctg ctg gca ctt gtt 259 Ser Thr Asp Tyr Leu Met Ile Ile Gly Gly Ser Leu Leu Ala Leu Val 40 45 50 ggt ggt gct gct gtg att tgg ggc ttt gtc aac gtg atg cgc aag ctc 307 Gly Gly Ala Ala Val Ile Trp Gly Phe Val Asn Val Met Arg Lys Leu 55 60 65 ttc ggt ggt cag agt ggt cag cag att cag tgg ttc acc act att ttg 355 Phe Gly Gly Gln Ser Gly Gln Gln Ile Gln Trp Phe Thr Thr Ile Leu 70 75 80 85 ctc atc att gtc ggt ggt gcg ttc cta gtt ggt ggt atc aca ctt gcg 403 Leu Ile Ile Val Gly Gly Ala Phe Leu Val Gly Gly Ile Thr Leu Ala 90 95 100 ctg aac ttt gcg tct ggt gca ggc gat acg gtt acc ggt ttc ggt aca 451 Leu Asn Phe Ala Ser Gly Ala Gly Asp Thr Val Thr Gly Phe Gly Thr 105 110 115 ggt ggc taagattcag caccgcacaa aaagcacatt 487 Gly Gly <210> 378 <211> 119 <212> PRT <213> Corynebacterium glutamicum <400> 378 Met Ser Ile Pro Gly Asn Val Ser Tyr Val Ala Gln Gly Gly Thr Gly 1 5 10 15 Trp Asp Gly Ala Asp Gln Tyr Thr Thr Gly Glu Ser Trp Asp Leu Gln 20 25 30 Ser Phe Leu Glu Asn Ser Thr Asp Tyr Leu Met Ile Ile Gly Gly Ser 35 40 45 Leu Leu Ala Leu Val Gly Gly Ala Ala Val Ile Trp Gly Phe Val Asn 50 55 60 Val Met Arg Lys Leu Phe Gly Gly Gln Ser Gly Gln Gln Ile Gln Trp 65 70 75 80 Phe Thr Thr Ile Leu Leu Ile Ile Val Gly Gly Ala Phe Leu Val Gly 85 90 95 Gly Ile Thr Leu Ala Leu Asn Phe Ala Ser Gly Ala Gly Asp Thr Val 100 105 110 Thr Gly Phe Gly Thr Gly Gly 115 <210> 379 <211> 445 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(415) <223> RXA03682 <400> 379 gtaacggtat accatagaaa caatctgtaa tcctctaagg agcgcgatga aagattcgtc 60 taagtttgcg acaaaaaatt attctgctcg actgttctta ttg ctt tat gtc tta 115 Leu Leu Tyr Val Leu 1 5 acg gtc gta gtc ggg tgg ata ttt gcc ctt ggg aat ccc tat tca gta 163 Thr Val Val Val Gly Trp Ile Phe Ala Leu Gly Asn Pro Tyr Ser Val 10 15 20 gta acc gct ttt tca att ttt gtt gga gtt ggt ttt gct gta gct gca 211 Val Thr Ala Phe Ser Ile Phe Val Gly Val Gly Phe Ala Val Ala Ala 25 30 35 gtt gct tgt gcc cta aca aga aga gct ccc ttg tgg ctt ttg ggg ttc 259 Val Ala Cys Ala Leu Thr Arg Arg Ala Pro Leu Trp Leu Leu Gly Phe 40 45 50 tta ggt ggt gta gga atc gtt ctt gtc ttg atg gga atc tat ttc agg 307 Leu Gly Gly Val Gly Ile Val Leu Val Leu Met Gly Ile Tyr Phe Arg 55 60 65 gta act cag cct gat gga atc cta act gga tat ttg ata ccg att ggt 355 Val Thr Gln Pro Asp Gly Ile Leu Thr Gly Tyr Leu Ile Pro Ile Gly 70 75 80 85 ttt gga ttt ttt ctc gca gaa gca gct gtg gca ata gag cgt tat tgg 403 Phe Gly Phe Phe Leu Ala Glu Ala Ala Val Ala Ile Glu Arg Tyr Trp 90 95 100 cat cgt cgt cac taagcactgc gttcttaaag gaagagcttt 445 His Arg Arg His 105 <210> 380 <211> 105 <212> PRT <213> Corynebacterium glutamicum <400> 380 Leu Leu Tyr Val Leu Thr Val Val Val Gly Trp Ile Phe Ala Leu Gly 1 5 10 15 Asn Pro Tyr Ser Val Val Thr Ala Phe Ser Ile Phe Val Gly Val Gly 20 25 30 Phe Ala Val Ala Ala Val Ala Cys Ala Leu Thr Arg Arg Ala Pro Leu 35 40 45 Trp Leu Leu Gly Phe Leu Gly Gly Val Gly Ile Val Leu Val Leu Met 50 55 60 Gly Ile Tyr Phe Arg Val Thr Gln Pro Asp Gly Ile Leu Thr Gly Tyr 65 70 75 80 Leu Ile Pro Ile Gly Phe Gly Phe Phe Leu Ala Glu Ala Ala Val Ala 85 90 95 Ile Glu Arg Tyr Trp His Arg Arg His 100 105 <210> 381 <211> 1003 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(973) <223> RXA03700 <400> 381 agcgaatcgg attcagtgat ttgcttgcgg gcgcagaaat gatttttcaa ttagacacac 60 ttagacacac gtaactaaaa cctcagggaa gtgactgata atg gct aat ccg ctc 115 Met Ala Asn Pro Leu 1 5 agc aag ggc tgg aag tat ctc atg gca tcg ttc gac aac aag atc gat 163 Ser Lys Gly Trp Lys Tyr Leu Met Ala Ser Phe Asp Asn Lys Ile Asp 10 15 20 gag aat gca gat cca aag atc caa att cag caa gct aca gaa gct gcc 211 Glu Asn Ala Asp Pro Lys Ile Gln Ile Gln Gln Ala Thr Glu Ala Ala 25 30 35 cag aag cag cac cag cag att atg cag cac gct tct cag att atc ggt 259 Gln Lys Gln His Gln Gln Ile Met Gln His Ala Ser Gln Ile Ile Gly 40 45 50 cag cag aag cag ctt gag atg aaa ttg aac cgc ttg gtt act gac cgc 307 Gln Gln Lys Gln Leu Glu Met Lys Leu Asn Arg Leu Val Thr Asp Arg 55 60 65 gat aag ttg cag gaa cag gct cgt cag gca att cag ttg gca gat aag 355 Asp Lys Leu Gln Glu Gln Ala Arg Gln Ala Ile Gln Leu Ala Asp Lys 70 75 80 85 tcc gca aac gaa ggc gac agt gtt aag gct cag gag ttc aac aac act 403 Ser Ala Asn Glu Gly Asp Ser Val Lys Ala Gln Glu Phe Asn Asn Thr 90 95 100 gct gag gtt ttt gct tcc cag ttg gta gct gtg gaa cag cag ttg gag 451 Ala Glu Val Phe Ala Ser Gln Leu Val Ala Val Glu Gln Gln Leu Glu 105 110 115 cag act act gcg ctt cat cag cag gct gag gtt gcg gcg aag gat gct 499 Gln Thr Thr Ala Leu His Gln Gln Ala Glu Val Ala Ala Lys Asp Ala 120 125 130 gtt gcg aag tct aaa gag tct gag atg cgc ctg aaa gag cag atg tct 547 Val Ala Lys Ser Lys Glu Ser Glu Met Arg Leu Lys Glu Gln Met Ser 135 140 145 cag att gat gct cta cgt gcg cag gct gat cag gcg aag atg cag gaa 595 Gln Ile Asp Ala Leu Arg Ala Gln Ala Asp Gln Ala Lys Met Gln Glu 150 155 160 165 agt gtc act aag tct atg gat tct ttg aat cag ttt ggc act cag gat 643 Ser Val Thr Lys Ser Met Asp Ser Leu Asn Gln Phe Gly Thr Gln Asp 170 175 180 tct tct gtt cct acc ctt gat gcg gtg cgt gag aag atc gag cgt cga 691 Ser Ser Val Pro Thr Leu Asp Ala Val Arg Glu Lys Ile Glu Arg Arg 185 190 195 tac gca gat gct ttg ggc gcg cag gaa ctt acc cag aac act gtt agt 739 Tyr Ala Asp Ala Leu Gly Ala Gln Glu Leu Thr Gln Asn Thr Val Ser 200 205 210 gat cgc atg gct gag att gcg cag tcc ggc acc gat atg cgg gcg tca 787 Asp Arg Met Ala Glu Ile Ala Gln Ser Gly Thr Asp Met Arg Ala Ser 215 220 225 gct cgt ttg gct gaa ctt cgc gcg gag gcg ctg ggc acg tcc gca acg 835 Ala Arg Leu Ala Glu Leu Arg Ala Glu Ala Leu Gly Thr Ser Ala Thr 230 235 240 245 cct aag ggc cag cta gag gca ggt gtc gag gat gcg gaa gaa ctt atc 883 Pro Lys Gly Gln Leu Glu Ala Gly Val Glu Asp Ala Glu Glu Leu Ile 250 255 260 gac gaa acc tcc acc cct tca gct acc cca gaa acc gca agc cca gaa 931 Asp Glu Thr Ser Thr Pro Ser Ala Thr Pro Glu Thr Ala Ser Pro Glu 265 270 275 gct gat gct cca gaa gca tcc gca gac gag tcc gag aag aaa 973 Ala Asp Ala Pro Glu Ala Ser Ala Asp Glu Ser Glu Lys Lys 280 285 290 taacctaaac acaaaaaact ggggctaact 1003 <210> 382 <211> 291 <212> PRT <213> Corynebacterium glutamicum <400> 382 Met Ala Asn Pro Leu Ser Lys Gly Trp Lys Tyr Leu Met Ala Ser Phe 1 5 10 15 Asp Asn Lys Ile Asp Glu Asn Ala Asp Pro Lys Ile Gln Ile Gln Gln 20 25 30 Ala Thr Glu Ala Ala Gln Lys Gln His Gln Gln Ile Met Gln His Ala 35 40 45 Ser Gln Ile Ile Gly Gln Gln Lys Gln Leu Glu Met Lys Leu Asn Arg 50 55 60 Leu Val Thr Asp Arg Asp Lys Leu Gln Glu Gln Ala Arg Gln Ala Ile 65 70 75 80 Gln Leu Ala Asp Lys Ser Ala Asn Glu Gly Asp Ser Val Lys Ala Gln 85 90 95 Glu Phe Asn Asn Thr Ala Glu Val Phe Ala Ser Gln Leu Val Ala Val 100 105 110 Glu Gln Gln Leu Glu Gln Thr Thr Ala Leu His Gln Gln Ala Glu Val 115 120 125 Ala Ala Lys Asp Ala Val Ala Lys Ser Lys Glu Ser Glu Met Arg Leu 130 135 140 Lys Glu Gln Met Ser Gln Ile Asp Ala Leu Arg Ala Gln Ala Asp Gln 145 150 155 160 Ala Lys Met Gln Glu Ser Val Thr Lys Ser Met Asp Ser Leu Asn Gln 165 170 175 Phe Gly Thr Gln Asp Ser Ser Val Pro Thr Leu Asp Ala Val Arg Glu 180 185 190 Lys Ile Glu Arg Arg Tyr Ala Asp Ala Leu Gly Ala Gln Glu Leu Thr 195 200 205 Gln Asn Thr Val Ser Asp Arg Met Ala Glu Ile Ala Gln Ser Gly Thr 210 215 220 Asp Met Arg Ala Ser Ala Arg Leu Ala Glu Leu Arg Ala Glu Ala Leu 225 230 235 240 Gly Thr Ser Ala Thr Pro Lys Gly Gln Leu Glu Ala Gly Val Glu Asp 245 250 255 Ala Glu Glu Leu Ile Asp Glu Thr Ser Thr Pro Ser Ala Thr Pro Glu 260 265 270 Thr Ala Ser Pro Glu Ala Asp Ala Pro Glu Ala Ser Ala Asp Glu Ser 275 280 285 Glu Lys Lys 290 <210> 383 <211> 406 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(376) <223> RXA03803 <400> 383 cggcaaaatg atggccaaaa ccaggaaatc ttggtgtcga aagtacaacg aggttaaggg 60 aattaacccg agggcccaga tctaacggtg agctgccaac atg agg ggt ggt cga 115 Met Arg Gly Gly Arg 1 5 agc act tcg acc ctg gag act ggg caa aac cag ccc aca ctg ccc acg 163 Ser Thr Ser Thr Leu Glu Thr Gly Gln Asn Gln Pro Thr Leu Pro Thr 10 15 20 gac ctc gaa aag agg acc cgt ggg cat tcc tgt ctg gtt tac agg cct 211 Asp Leu Glu Lys Arg Thr Arg Gly His Ser Cys Leu Val Tyr Arg Pro 25 30 35 caa aac cgg tca cag ctg ccc acg aaa ctc gat ttc gag atc cgt ggg 259 Gln Asn Arg Ser Gln Leu Pro Thr Lys Leu Asp Phe Glu Ile Arg Gly 40 45 50 cac tct cgt ttg gtt gct gta gca acc tgc ctc aaa gcc cgg aaa ttt 307 His Ser Arg Leu Val Ala Val Ala Thr Cys Leu Lys Ala Arg Lys Phe 55 60 65 agc ccg ctc aga atc gct tct cag gcc ttg aat gca cga atc cct cac 355 Ser Pro Leu Arg Ile Ala Ser Gln Ala Leu Asn Ala Arg Ile Pro His 70 75 80 85 atg tta ccc atc ggg gat ttc taggcccgca aatcggcaca cagagcatca 406 Met Leu Pro Ile Gly Asp Phe 90 <210> 384 <211> 92 <212> PRT <213> Corynebacterium glutamicum <400> 384 Met Arg Gly Gly Arg Ser Thr Ser Thr Leu Glu Thr Gly Gln Asn Gln 1 5 10 15 Pro Thr Leu Pro Thr Asp Leu Glu Lys Arg Thr Arg Gly His Ser Cys 20 25 30 Leu Val Tyr Arg Pro Gln Asn Arg Ser Gln Leu Pro Thr Lys Leu Asp 35 40 45 Phe Glu Ile Arg Gly His Ser Arg Leu Val Ala Val Ala Thr Cys Leu 50 55 60 Lys Ala Arg Lys Phe Ser Pro Leu Arg Ile Ala Ser Gln Ala Leu Asn 65 70 75 80 Ala Arg Ile Pro His Met Leu Pro Ile Gly Asp Phe 85 90 <210> 385 <211> 337 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(307) <223> RXA03823 <400> 385 aagcctggtt acgctgatgg tactgcactc gggagggtgt gggagagtag gttaccgccg 60 accaaaaact taaaatagta tggataagcc cagaaacact gtg tgt ttc tgg gtt 115 Val Cys Phe Trp Val 1 5 tat tcg tgt ttg agg ggg tgt ggt gga tac aca tgg ttg tgt gtt cac 163 Tyr Ser Cys Leu Arg Gly Cys Gly Gly Tyr Thr Trp Leu Cys Val His 10 15 20 tac acc ctc tct ttt ttg tgt ttg tgg ggg tct tgg gcc cct tgt gca 211 Tyr Thr Leu Ser Phe Leu Cys Leu Trp Gly Ser Trp Ala Pro Cys Ala 25 30 35 cgt ggc acc tgc gcc tgg ggg caa gcg tcg aca agc aaa aag ctc gta 259 Arg Gly Thr Cys Ala Trp Gly Gln Ala Ser Thr Ser Lys Lys Leu Val 40 45 50 cct tct tta ttt gag gag gta cga gct tta tct gtc ctg gtg aag ttt 307 Pro Ser Leu Phe Glu Glu Val Arg Ala Leu Ser Val Leu Val Lys Phe 55 60 65 tagattttta cagcgatagc tggctcagga 337 <210> 386 <211> 69 <212> PRT <213> Corynebacterium glutamicum <400> 386 Val Cys Phe Trp Val Tyr Ser Cys Leu Arg Gly Cys Gly Gly Tyr Thr 1 5 10 15 Trp Leu Cys Val His Tyr Thr Leu Ser Phe Leu Cys Leu Trp Gly Ser 20 25 30 Trp Ala Pro Cys Ala Arg Gly Thr Cys Ala Trp Gly Gln Ala Ser Thr 35 40 45 Ser Lys Lys Leu Val Pro Ser Leu Phe Glu Glu Val Arg Ala Leu Ser 50 55 60 Val Leu Val Lys Phe 65 <210> 387 <211> 1564 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1534) <223> RXA03886 <400> 387 caccatccag atcgctgagc tgctggttaa gtaaaaaccc gccattaaaa actccgcttg 60 agtgctacac tttaagcggg gttttaatgt ttgaggggcg atg ggg gtc gag ctt 115 Met Gly Val Glu Leu 1 5 gtg aag tgg aat ttt cca caa gtt tta agt ttc ttt agc agg gga aac 163 Val Lys Trp Asn Phe Pro Gln Val Leu Ser Phe Phe Ser Arg Gly Asn 10 15 20 act gct gat agc act agc gat aaa gaa cat gaa aat gca acg gag cta 211 Thr Ala Asp Ser Thr Ser Asp Lys Glu His Glu Asn Ala Thr Glu Leu 25 30 35 gcg gcc gaa gct tta gcg gat gtc att ttt cag tgg aaa aac tgg gtc 259 Ala Ala Glu Ala Leu Ala Asp Val Ile Phe Gln Trp Lys Asn Trp Val 40 45 50 tac cga cgc gtt gat agt gtg cat cca tcc gaa gga gct cga ggg aga 307 Tyr Arg Arg Val Asp Ser Val His Pro Ser Glu Gly Ala Arg Gly Arg 55 60 65 ctc aga cac tcc atg gat tgc gaa cct cca cct gac cca cgg ctt gcg 355 Leu Arg His Ser Met Asp Cys Glu Pro Pro Pro Asp Pro Arg Leu Ala 70 75 80 85 tac aac gaa gtt gaa cgc cgt tat aac gat att aat gac gta aag gga 403 Tyr Asn Glu Val Glu Arg Arg Tyr Asn Asp Ile Asn Asp Val Lys Gly 90 95 100 caa cta atg gtc ccg cta gcg ttc att gaa aaa ggc ccg atg cgt cat 451 Gln Leu Met Val Pro Leu Ala Phe Ile Glu Lys Gly Pro Met Arg His 105 110 115 ctt gat gtc tgg aga aat gat ggg acg agc att cct gtc ctt ggt tcg 499 Leu Asp Val Trp Arg Asn Asp Gly Thr Ser Ile Pro Val Leu Gly Ser 120 125 130 gaa gaa act ggt gaa cta atg gtg gct gtc ctc atg ctg ttt ttg aag 547 Glu Glu Thr Gly Glu Leu Met Val Ala Val Leu Met Leu Phe Leu Lys 135 140 145 aaa aat ggc atc gag cga aca tct gaa ctt gaa gat gcg atg cgt gcc 595 Lys Asn Gly Ile Glu Arg Thr Ser Glu Leu Glu Asp Ala Met Arg Ala 150 155 160 165 ctt gtg ata tca aga gaa aag gga aac cta gca aaa gca acg aac cta 643 Leu Val Ile Ser Arg Glu Lys Gly Asn Leu Ala Lys Ala Thr Asn Leu 170 175 180 att gaa agt ggg gtg tgg gag ggc aaa aca tta tgg gat agt aat gat 691 Ile Glu Ser Gly Val Trp Glu Gly Lys Thr Leu Trp Asp Ser Asn Asp 185 190 195 cct gca gtg aga ttt gat gtg gga aca aaa gac ttg ctt ttg aat cta 739 Pro Ala Val Arg Phe Asp Val Gly Thr Lys Asp Leu Leu Leu Asn Leu 200 205 210 tct act gat ttt ttg ttg atc ggt ttg ttg ccc gcg gaa act tct gga 787 Ser Thr Asp Phe Leu Leu Ile Gly Leu Leu Pro Ala Glu Thr Ser Gly 215 220 225 atc agg caa gtt tta aaa ttt tca tat cac tgg gtg gtt gaa tta cct 835 Ile Arg Gln Val Leu Lys Phe Ser Tyr His Trp Val Val Glu Leu Pro 230 235 240 245 gac aga ggg ctt ctt aga tca ttg tgg ggt agc gtg tgt gtc gca ttt 883 Asp Arg Gly Leu Leu Arg Ser Leu Trp Gly Ser Val Cys Val Ala Phe 250 255 260 cga gca gct cca atg gaa att gaa tta cca aca cat atg ccc acg gat 931 Arg Ala Ala Pro Met Glu Ile Glu Leu Pro Thr His Met Pro Thr Asp 265 270 275 gcg aaa tcg tac cat ctt gaa ttc cac aca ccg cct gag tta gat act 979 Ala Lys Ser Tyr His Leu Glu Phe His Thr Pro Pro Glu Leu Asp Thr 280 285 290 caa gag tta tcg ctt cca gtt gat tcc aag aat aag ggc cat cgg gtc 1027 Gln Glu Leu Ser Leu Pro Val Asp Ser Lys Asn Lys Gly His Arg Val 295 300 305 ggc tat cca act gac tct agt agg aca cct atc gcc cat gtg cac tcg 1075 Gly Tyr Pro Thr Asp Ser Ser Arg Thr Pro Ile Ala His Val His Ser 310 315 320 325 cat ttt tcc gag ata atg acc aca aat gca aaa gta aaa ttg gag gtt 1123 His Phe Ser Glu Ile Met Thr Thr Asn Ala Lys Val Lys Leu Glu Val 330 335 340 ccc aaa agg gga att tgg gtt act gca ctt tta tcg aat gca cta aca 1171 Pro Lys Arg Gly Ile Trp Val Thr Ala Leu Leu Ser Asn Ala Leu Thr 345 350 355 gcc gga att ttt atc cta gcc ttg ttg cta ccc aat gca act gat gct 1219 Ala Gly Ile Phe Ile Leu Ala Leu Leu Leu Pro Asn Ala Thr Asp Ala 360 365 370 ttg cgt agt gtt gga gga aat gca gcg gcc ttg atg ctt gca gcg ccg 1267 Leu Arg Ser Val Gly Gly Asn Ala Ala Ala Leu Met Leu Ala Ala Pro 375 380 385 gca gta ttt gta agc ttt ctc atc ttt cct aaa gaa cat att ttt gta 1315 Ala Val Phe Val Ser Phe Leu Ile Phe Pro Lys Glu His Ile Phe Val 390 395 400 405 tct tcc atg ctt aat ccg ctt cgt atc gtc gta gga ata tgc gca cta 1363 Ser Ser Met Leu Asn Pro Leu Arg Ile Val Val Gly Ile Cys Ala Leu 410 415 420 ctg ctc ttt atg atg gca gga agt ctt gtg ggt ggg ttg gag cga cca 1411 Leu Leu Phe Met Met Ala Gly Ser Leu Val Gly Gly Leu Glu Arg Pro 425 430 435 ttt ctt att ctt ctg tgg tca ttt gga gct ggg ttt tca ttg cta gtt 1459 Phe Leu Ile Leu Leu Trp Ser Phe Gly Ala Gly Phe Ser Leu Leu Val 440 445 450 gtt agc gca cta gta cta ggt cca ctc cta gga aag ttt ttt gag agg 1507 Val Ser Ala Leu Val Leu Gly Pro Leu Leu Gly Lys Phe Phe Glu Arg 455 460 465 ttg cac ctg cgc cct agt act aag aac tgatgtagag tttgtggaaa 1554 Leu His Leu Arg Pro Ser Thr Lys Asn 470 475 gatgagttag 1564 <210> 388 <211> 478 <212> PRT <213> Corynebacterium glutamicum <400> 388 Met Gly Val Glu Leu Val Lys Trp Asn Phe Pro Gln Val Leu Ser Phe 1 5 10 15 Phe Ser Arg Gly Asn Thr Ala Asp Ser Thr Ser Asp Lys Glu His Glu 20 25 30 Asn Ala Thr Glu Leu Ala Ala Glu Ala Leu Ala Asp Val Ile Phe Gln 35 40 45 Trp Lys Asn Trp Val Tyr Arg Arg Val Asp Ser Val His Pro Ser Glu 50 55 60 Gly Ala Arg Gly Arg Leu Arg His Ser Met Asp Cys Glu Pro Pro Pro 65 70 75 80 Asp Pro Arg Leu Ala Tyr Asn Glu Val Glu Arg Arg Tyr Asn Asp Ile 85 90 95 Asn Asp Val Lys Gly Gln Leu Met Val Pro Leu Ala Phe Ile Glu Lys 100 105 110 Gly Pro Met Arg His Leu Asp Val Trp Arg Asn Asp Gly Thr Ser Ile 115 120 125 Pro Val Leu Gly Ser Glu Glu Thr Gly Glu Leu Met Val Ala Val Leu 130 135 140 Met Leu Phe Leu Lys Lys Asn Gly Ile Glu Arg Thr Ser Glu Leu Glu 145 150 155 160 Asp Ala Met Arg Ala Leu Val Ile Ser Arg Glu Lys Gly Asn Leu Ala 165 170 175 Lys Ala Thr Asn Leu Ile Glu Ser Gly Val Trp Glu Gly Lys Thr Leu 180 185 190 Trp Asp Ser Asn Asp Pro Ala Val Arg Phe Asp Val Gly Thr Lys Asp 195 200 205 Leu Leu Leu Asn Leu Ser Thr Asp Phe Leu Leu Ile Gly Leu Leu Pro 210 215 220 Ala Glu Thr Ser Gly Ile Arg Gln Val Leu Lys Phe Ser Tyr His Trp 225 230 235 240 Val Val Glu Leu Pro Asp Arg Gly Leu Leu Arg Ser Leu Trp Gly Ser 245 250 255 Val Cys Val Ala Phe Arg Ala Ala Pro Met Glu Ile Glu Leu Pro Thr 260 265 270 His Met Pro Thr Asp Ala Lys Ser Tyr His Leu Glu Phe His Thr Pro 275 280 285 Pro Glu Leu Asp Thr Gln Glu Leu Ser Leu Pro Val Asp Ser Lys Asn 290 295 300 Lys Gly His Arg Val Gly Tyr Pro Thr Asp Ser Ser Arg Thr Pro Ile 305 310 315 320 Ala His Val His Ser His Phe Ser Glu Ile Met Thr Thr Asn Ala Lys 325 330 335 Val Lys Leu Glu Val Pro Lys Arg Gly Ile Trp Val Thr Ala Leu Leu 340 345 350 Ser Asn Ala Leu Thr Ala Gly Ile Phe Ile Leu Ala Leu Leu Leu Pro 355 360 365 Asn Ala Thr Asp Ala Leu Arg Ser Val Gly Gly Asn Ala Ala Ala Leu 370 375 380 Met Leu Ala Ala Pro Ala Val Phe Val Ser Phe Leu Ile Phe Pro Lys 385 390 395 400 Glu His Ile Phe Val Ser Ser Met Leu Asn Pro Leu Arg Ile Val Val 405 410 415 Gly Ile Cys Ala Leu Leu Leu Phe Met Met Ala Gly Ser Leu Val Gly 420 425 430 Gly Leu Glu Arg Pro Phe Leu Ile Leu Leu Trp Ser Phe Gly Ala Gly 435 440 445 Phe Ser Leu Leu Val Val Ser Ala Leu Val Leu Gly Pro Leu Leu Gly 450 455 460 Lys Phe Phe Glu Arg Leu His Leu Arg Pro Ser Thr Lys Asn 465 470 475 <210> 389 <211> 484 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(454) <223> RXA03940 <400> 389 aactcgaccg cttaaacggg cttctagagt gttgatgctt taaggggccg taaatgtagg 60 gttctttgga tgggagctaa ggccagggct cacttttgct ttg atc ggg agg ctc 115 Leu Ile Gly Arg Leu 1 5 caa gcc agc aaa cca gac aca cgt gcc cgc ggt tcg ggt ttt tcg agt 163 Gln Ala Ser Lys Pro Asp Thr Arg Ala Arg Gly Ser Gly Phe Ser Ser 10 15 20 tgg tgg gca ctc tgg ttt ggt tta tcg ctt tcg aaa ccg gtc cca gtt 211 Trp Trp Ala Leu Trp Phe Gly Leu Ser Leu Ser Lys Pro Val Pro Val 25 30 35 gcc caa gtg ttt cga ttt gag gat tcg tgg gca cgc ctg tct ggt tgg 259 Ala Gln Val Phe Arg Phe Glu Asp Ser Trp Ala Arg Leu Ser Gly Trp 40 45 50 cca gaa aaa ctg gcc tta gac cca aaa aac cag act cgc tgt atg gct 307 Pro Glu Lys Leu Ala Leu Asp Pro Lys Asn Gln Thr Arg Cys Met Ala 55 60 65 gtt aga cgc gct tcc gtg act cac ttt agg gga acg ttc ctt cga aaa 355 Val Arg Arg Ala Ser Val Thr His Phe Arg Gly Thr Phe Leu Arg Lys 70 75 80 85 act cga ccc ttt aaa cgg gct tct aga gcc ttg gaa cca ttt gga ctt 403 Thr Arg Pro Phe Lys Arg Ala Ser Arg Ala Leu Glu Pro Phe Gly Leu 90 95 100 ctt cgg agt cta acc aga gta tgg aca aca ata att cct acc tct ggc 451 Leu Arg Ser Leu Thr Arg Val Trp Thr Thr Ile Ile Pro Thr Ser Gly 105 110 115 cag taacctacga cgaagtctcc catgaattaa 484 Gln <210> 390 <211> 118 <212> PRT <213> Corynebacterium glutamicum <400> 390 Leu Ile Gly Arg Leu Gln Ala Ser Lys Pro Asp Thr Arg Ala Arg Gly 1 5 10 15 Ser Gly Phe Ser Ser Trp Trp Ala Leu Trp Phe Gly Leu Ser Leu Ser 20 25 30 Lys Pro Val Pro Val Ala Gln Val Phe Arg Phe Glu Asp Ser Trp Ala 35 40 45 Arg Leu Ser Gly Trp Pro Glu Lys Leu Ala Leu Asp Pro Lys Asn Gln 50 55 60 Thr Arg Cys Met Ala Val Arg Arg Ala Ser Val Thr His Phe Arg Gly 65 70 75 80 Thr Phe Leu Arg Lys Thr Arg Pro Phe Lys Arg Ala Ser Arg Ala Leu 85 90 95 Glu Pro Phe Gly Leu Leu Arg Ser Leu Thr Arg Val Trp Thr Thr Ile 100 105 110 Ile Pro Thr Ser Gly Gln 115 <210> 391 <211> 418 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(388) <223> RXA03947 <400> 391 acgcccccaa atacctgcga gtcacataag tattcccaaa caattcactt taaggggtca 60 acatccccaa aataggtcca catatggatg aggcccgttt atg gcc tta aaa acg 115 Met Ala Leu Lys Thr 1 5 att ctg agg cac cta cgg ttt gtt gcg aat gag aca ggt gtg att cct 163 Ile Leu Arg His Leu Arg Phe Val Ala Asn Glu Thr Gly Val Ile Pro 10 15 20 gca ggt tcc ctg atc aag gat tca cca caa tcc tgt ggc cag acc tta 211 Ala Gly Ser Leu Ile Lys Asp Ser Pro Gln Ser Cys Gly Gln Thr Leu 25 30 35 aaa tcg aac aga ttt ttg cac cac agg ccg tgg aag ttg caa aaa tcc 259 Lys Ser Asn Arg Phe Leu His His Arg Pro Trp Lys Leu Gln Lys Ser 40 45 50 acc aca aac cgc ccc cta atc agc cat ttg tgg tgg ata ttc gca cat 307 Thr Thr Asn Arg Pro Leu Ile Ser His Leu Trp Trp Ile Phe Ala His 55 60 65 tct ttc gct acg ccc tca ata tgg aaa ttt cgg gcc cta att agc tgc 355 Ser Phe Ala Thr Pro Ser Ile Trp Lys Phe Arg Ala Leu Ile Ser Cys 70 75 80 85 ggt cgc cga gca aat tgg cgg ctc cgg cgt cga taagctgttg tgcaacgagc 408 Gly Arg Arg Ala Asn Trp Arg Leu Arg Arg Arg 90 95 tcgccgagct 418 <210> 392 <211> 96 <212> PRT <213> Corynebacterium glutamicum <400> 392 Met Ala Leu Lys Thr Ile Leu Arg His Leu Arg Phe Val Ala Asn Glu 1 5 10 15 Thr Gly Val Ile Pro Ala Gly Ser Leu Ile Lys Asp Ser Pro Gln Ser 20 25 30 Cys Gly Gln Thr Leu Lys Ser Asn Arg Phe Leu His His Arg Pro Trp 35 40 45 Lys Leu Gln Lys Ser Thr Thr Asn Arg Pro Leu Ile Ser His Leu Trp 50 55 60 Trp Ile Phe Ala His Ser Phe Ala Thr Pro Ser Ile Trp Lys Phe Arg 65 70 75 80 Ala Leu Ile Ser Cys Gly Arg Arg Ala Asn Trp Arg Leu Arg Arg Arg 85 90 95 <210> 393 <211> 712 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(682) <223> RXA03955 <400> 393 agcgtgccgg tgcaaaccaa atcctcacgt actttgccgt tgacgctgcc cgcgcactgc 60 gaaacgctta acaagaacta actgattagt aggactcccc atg agc atg ctt ccc 115 Met Ser Met Leu Pro 1 5 aat ctc aca ccg aag aaa tct gcc ccg cct tca tct tct gct tct gcg 163 Asn Leu Thr Pro Lys Lys Ser Ala Pro Pro Ser Ser Ser Ala Ser Ala 10 15 20 aaa aat gct gga gaa aag aag gaa gac acc gtc aag ctc ctg att cag 211 Lys Asn Ala Gly Glu Lys Lys Glu Asp Thr Val Lys Leu Leu Ile Gln 25 30 35 atg tgg gct gtg atg atc ggt ttg gag ctg ctg cac cag atc tta aac 259 Met Trp Ala Val Met Ile Gly Leu Glu Leu Leu His Gln Ile Leu Asn 40 45 50 gtg gtg atg agc ttt acg gac ccg act gcg ctg cgg act gtt gcc aaa 307 Val Val Met Ser Phe Thr Asp Pro Thr Ala Leu Arg Thr Val Ala Lys 55 60 65 gaa caa gca gca gca cag ggg ctt tcc gat ggc att gtt aac gcc aca 355 Glu Gln Ala Ala Ala Gln Gly Leu Ser Asp Gly Ile Val Asn Ala Thr 70 75 80 85 gtc atc gca gca atc ttg gtc atg gga ttc ttc aac ctc att gtg att 403 Val Ile Ala Ala Ile Leu Val Met Gly Phe Phe Asn Leu Ile Val Ile 90 95 100 gcc att ttg tcc tgg atg gtg gtg atg gtg aaa aac cgt tcc aaa cgc 451 Ala Ile Leu Ser Trp Met Val Val Met Val Lys Asn Arg Ser Lys Arg 105 110 115 cta ccg acg gca ttc ttg ctg ctc acc atc ttc agt ttc ttc ttt atc 499 Leu Pro Thr Ala Phe Leu Leu Leu Thr Ile Phe Ser Phe Phe Phe Ile 120 125 130 cta aga gtc ttg atg ctg ttt ttc gcc tca cct ggt ggg act gat gtt 547 Leu Arg Val Leu Met Leu Phe Phe Ala Ser Pro Gly Gly Thr Asp Val 135 140 145 cca atg gca cta ttt gct atc gac ggt tgt gta caa atc ctc gtc gga 595 Pro Met Ala Leu Phe Ala Ile Asp Gly Cys Val Gln Ile Leu Val Gly 150 155 160 165 gtg agc gcc ggt gtg gca tat gcg ctc tcg cgc act gag cag cct gtc 643 Val Ser Ala Gly Val Ala Tyr Ala Leu Ser Arg Thr Glu Gln Pro Val 170 175 180 aaa atg ctc acc gac tac gca cca gaa gac gct aaa cgg taagtactga 692 Lys Met Leu Thr Asp Tyr Ala Pro Glu Asp Ala Lys Arg 185 190 agaattttta aagacgacgg 712 <210> 394 <211> 194 <212> PRT <213> Corynebacterium glutamicum <400> 394 Met Ser Met Leu Pro Asn Leu Thr Pro Lys Lys Ser Ala Pro Pro Ser 1 5 10 15 Ser Ser Ala Ser Ala Lys Asn Ala Gly Glu Lys Lys Glu Asp Thr Val 20 25 30 Lys Leu Leu Ile Gln Met Trp Ala Val Met Ile Gly Leu Glu Leu Leu 35 40 45 His Gln Ile Leu Asn Val Val Met Ser Phe Thr Asp Pro Thr Ala Leu 50 55 60 Arg Thr Val Ala Lys Glu Gln Ala Ala Ala Gln Gly Leu Ser Asp Gly 65 70 75 80 Ile Val Asn Ala Thr Val Ile Ala Ala Ile Leu Val Met Gly Phe Phe 85 90 95 Asn Leu Ile Val Ile Ala Ile Leu Ser Trp Met Val Val Met Val Lys 100 105 110 Asn Arg Ser Lys Arg Leu Pro Thr Ala Phe Leu Leu Leu Thr Ile Phe 115 120 125 Ser Phe Phe Phe Ile Leu Arg Val Leu Met Leu Phe Phe Ala Ser Pro 130 135 140 Gly Gly Thr Asp Val Pro Met Ala Leu Phe Ala Ile Asp Gly Cys Val 145 150 155 160 Gln Ile Leu Val Gly Val Ser Ala Gly Val Ala Tyr Ala Leu Ser Arg 165 170 175 Thr Glu Gln Pro Val Lys Met Leu Thr Asp Tyr Ala Pro Glu Asp Ala 180 185 190 Lys Arg <210> 395 <211> 322 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(292) <223> RXA03975 <400> 395 agacgcatca atcgcttcgt ggtcgtaggc cttgagccta atgcggatct tttgtcccgc 60 cacgcttatc ctcttcctcg ctcgtcccac atcttccatt ttg gaa aag cgg tgg 115 Leu Glu Lys Arg Trp 1 5 gaa ttc gct tca ttc ttt ctc tat aac gtt gtc cgg gct tgg ggc tcg 163 Glu Phe Ala Ser Phe Phe Leu Tyr Asn Val Val Arg Ala Trp Gly Ser 10 15 20 ggc gca acg cca gtg ttt aac ctg acc tgt caa atg ctt ctg aca ttg 211 Gly Ala Thr Pro Val Phe Asn Leu Thr Cys Gln Met Leu Leu Thr Leu 25 30 35 gat cac ggg cgc tgt aca aat aaa acg ctc cac gat gaa ccc aac aat 259 Asp His Gly Arg Cys Thr Asn Lys Thr Leu His Asp Glu Pro Asn Asn 40 45 50 gaa gtc agg gaa atc gga agg gac caa aat gcg tgatctaggc cctaacgtaa 312 Glu Val Arg Glu Ile Gly Arg Asp Gln Asn Ala 55 60 ctgccgctgt 322 <210> 396 <211> 64 <212> PRT <213> Corynebacterium glutamicum <400> 396 Leu Glu Lys Arg Trp Glu Phe Ala Ser Phe Phe Leu Tyr Asn Val Val 1 5 10 15 Arg Ala Trp Gly Ser Gly Ala Thr Pro Val Phe Asn Leu Thr Cys Gln 20 25 30 Met Leu Leu Thr Leu Asp His Gly Arg Cys Thr Asn Lys Thr Leu His 35 40 45 Asp Glu Pro Asn Asn Glu Val Arg Glu Ile Gly Arg Asp Gln Asn Ala 50 55 60 <210> 397 <211> 604 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(574) <223> RXA04007 <400> 397 ggccggtggg caagatgctt ctggaaatat aatgatgtgc tcaggcggac aatgggtcta 60 tgggccataa atctaaaatc aaagagtgca ctcctgcagc atg ggt ttt ggg aag 115 Met Gly Phe Gly Lys 1 5 gcg ata ctc tta gaa att atg gat ccg atg aac agc tac aac acc atg 163 Ala Ile Leu Leu Glu Ile Met Asp Pro Met Asn Ser Tyr Asn Thr Met 10 15 20 aag tcc cac gtc acc cca att cca acg ccg gtg agc gtg cgg ctg agt 211 Lys Ser His Val Thr Pro Ile Pro Thr Pro Val Ser Val Arg Leu Ser 25 30 35 agc tcg gta tta gta ggt gct gcc atc gct tca tta acc act gat cta 259 Ser Ser Val Leu Val Gly Ala Ala Ile Ala Ser Leu Thr Thr Asp Leu 40 45 50 gcc ccg gcc gta aag ttt tct gtc act gga gtt ggt ctg gca ctc gcg 307 Ala Pro Ala Val Lys Phe Ser Val Thr Gly Val Gly Leu Ala Leu Ala 55 60 65 ctg ctc atc gct ttt gcg cat cct tac cgt ggg gag atg agg atg tac 355 Leu Leu Ile Ala Phe Ala His Pro Tyr Arg Gly Glu Met Arg Met Tyr 70 75 80 85 cgc ttc caa aac aat att tca cca gtc ccc acc att ggc cag gtg atg 403 Arg Phe Gln Asn Asn Ile Ser Pro Val Pro Thr Ile Gly Gln Val Met 90 95 100 cca cta ttt ttc aca tgg ctg gcg ctg atg ctt gca ccg att att tca 451 Pro Leu Phe Phe Thr Trp Leu Ala Leu Met Leu Ala Pro Ile Ile Ser 105 110 115 gga gcg cca ttg tgg gca acg att cta gtg ttc ctg gca gct acc ggc 499 Gly Ala Pro Leu Trp Ala Thr Ile Leu Val Phe Leu Ala Ala Thr Gly 120 125 130 tgg atg tat tta acg ttc ccc cac gtg gat ggc agc cgg aag ctg gcg 547 Trp Met Tyr Leu Thr Phe Pro His Val Asp Gly Ser Arg Lys Leu Ala 135 140 145 ttc gct gaa ggc ccc cgc cga aac acc taaacggacc acccaggaaa 594 Phe Ala Glu Gly Pro Arg Arg Asn Thr 150 155 tcgacctaag 604 <210> 398 <211> 158 <212> PRT <213> Corynebacterium glutamicum <400> 398 Met Gly Phe Gly Lys Ala Ile Leu Leu Glu Ile Met Asp Pro Met Asn 1 5 10 15 Ser Tyr Asn Thr Met Lys Ser His Val Thr Pro Ile Pro Thr Pro Val 20 25 30 Ser Val Arg Leu Ser Ser Ser Val Leu Val Gly Ala Ala Ile Ala Ser 35 40 45 Leu Thr Thr Asp Leu Ala Pro Ala Val Lys Phe Ser Val Thr Gly Val 50 55 60 Gly Leu Ala Leu Ala Leu Leu Ile Ala Phe Ala His Pro Tyr Arg Gly 65 70 75 80 Glu Met Arg Met Tyr Arg Phe Gln Asn Asn Ile Ser Pro Val Pro Thr 85 90 95 Ile Gly Gln Val Met Pro Leu Phe Phe Thr Trp Leu Ala Leu Met Leu 100 105 110 Ala Pro Ile Ile Ser Gly Ala Pro Leu Trp Ala Thr Ile Leu Val Phe 115 120 125 Leu Ala Ala Thr Gly Trp Met Tyr Leu Thr Phe Pro His Val Asp Gly 130 135 140 Ser Arg Lys Leu Ala Phe Ala Glu Gly Pro Arg Arg Asn Thr 145 150 155 <210> 399 <211> 718 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(688) <223> RXA04075 <400> 399 taagaagtcg agttaaatat tcctgttttt gtattataag caattggact ccctagtatt 60 cacggatggg gagtcaatcg caaaagctag actggcgtct atg act gac atg tgg 115 Met Thr Asp Met Trp 1 5 ttt agc tct gac ctt cat tta ggt cac aaa ttc gtg gca tcg atg cgg 163 Phe Ser Ser Asp Leu His Leu Gly His Lys Phe Val Ala Ser Met Arg 10 15 20 ggt ttc gac gat cca gat gaa cac gat gaa gta ata ctg agc aat ttt 211 Gly Phe Asp Asp Pro Asp Glu His Asp Glu Val Ile Leu Ser Asn Phe 25 30 35 gag aac acg atc ggc cca gat gat gtg ctg tgg att ctg gga gat ctt 259 Glu Asn Thr Ile Gly Pro Asp Asp Val Leu Trp Ile Leu Gly Asp Leu 40 45 50 tcc tct ggt gcc cat cgc gct gaa gag cgc gcg ctg ggc tta att gct 307 Ser Ser Gly Ala His Arg Ala Glu Glu Arg Ala Leu Gly Leu Ile Ala 55 60 65 gag cgg ctg ggc ggc gtc gtc aag cat ctt gtt cct gga aac cac gat 355 Glu Arg Leu Gly Gly Val Val Lys His Leu Val Pro Gly Asn His Asp 70 75 80 85 tct tgc cac ccg atg tac cgg cat gcg tac aag cga cag cgg cgg ttt 403 Ser Cys His Pro Met Tyr Arg His Ala Tyr Lys Arg Gln Arg Arg Phe 90 95 100 ttg gag gtt ttt gat tcg gtt cag gcg ttt cag cgg atg aaa tgg gac 451 Leu Glu Val Phe Asp Ser Val Gln Ala Phe Gln Arg Met Lys Trp Asp 105 110 115 gac gag gat gtc tac ttg tcg cat ttc cct cgg ccg ggc caa gat cat 499 Asp Glu Asp Val Tyr Leu Ser His Phe Pro Arg Pro Gly Gln Asp His 120 125 130 ccg ggg atg gaa tcg cgg ttt gat gat ctc cgc ctg cgt gtg cct ttg 547 Pro Gly Met Glu Ser Arg Phe Asp Asp Leu Arg Leu Arg Val Pro Leu 135 140 145 ctg att cat ggg cat ttg cat tcc cag ttc ccc atg acg ggg ccg ggg 595 Leu Ile His Gly His Leu His Ser Gln Phe Pro Met Thr Gly Pro Gly 150 155 160 165 cag gtt gat gtt ggg gta gag gcg tgg ggt ttg aag ccg gca cct cgt 643 Gln Val Asp Val Gly Val Glu Ala Trp Gly Leu Lys Pro Ala Pro Arg 170 175 180 gaa tta gtg cag ctc aag ctg tgg gaa tcg ctg agc gag aag att 688 Glu Leu Val Gln Leu Lys Leu Trp Glu Ser Leu Ser Glu Lys Ile 185 190 195 taaaagacaa agaaggcgca tcctaaggaa 718 <210> 400 <211> 196 <212> PRT <213> Corynebacterium glutamicum <400> 400 Met Thr Asp Met Trp Phe Ser Ser Asp Leu His Leu Gly His Lys Phe 1 5 10 15 Val Ala Ser Met Arg Gly Phe Asp Asp Pro Asp Glu His Asp Glu Val 20 25 30 Ile Leu Ser Asn Phe Glu Asn Thr Ile Gly Pro Asp Asp Val Leu Trp 35 40 45 Ile Leu Gly Asp Leu Ser Ser Gly Ala His Arg Ala Glu Glu Arg Ala 50 55 60 Leu Gly Leu Ile Ala Glu Arg Leu Gly Gly Val Val Lys His Leu Val 65 70 75 80 Pro Gly Asn His Asp Ser Cys His Pro Met Tyr Arg His Ala Tyr Lys 85 90 95 Arg Gln Arg Arg Phe Leu Glu Val Phe Asp Ser Val Gln Ala Phe Gln 100 105 110 Arg Met Lys Trp Asp Asp Glu Asp Val Tyr Leu Ser His Phe Pro Arg 115 120 125 Pro Gly Gln Asp His Pro Gly Met Glu Ser Arg Phe Asp Asp Leu Arg 130 135 140 Leu Arg Val Pro Leu Leu Ile His Gly His Leu His Ser Gln Phe Pro 145 150 155 160 Met Thr Gly Pro Gly Gln Val Asp Val Gly Val Glu Ala Trp Gly Leu 165 170 175 Lys Pro Ala Pro Arg Glu Leu Val Gln Leu Lys Leu Trp Glu Ser Leu 180 185 190 Ser Glu Lys Ile 195 <210> 401 <211> 472 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(442) <223> RXA04085 <400> 401 gatctggacg gactcggcgc cgcagtcgtg ggcgagtatt tacgacaccg ctactgagca 60 ttggacgttt tcgccttagc caggccagca agaaccatga gtg att tgt ggg tat 115 Val Ile Cys Gly Tyr 1 5 tgc tgc ctg gct tac cag tcc aca caa caa cac tct gct cag aat cat 163 Cys Cys Leu Ala Tyr Gln Ser Thr Gln Gln His Ser Ala Gln Asn His 10 15 20 agg ggt cta aca aag tgt ccc aat caa cgg tta aac ctg gca ata ttt 211 Arg Gly Leu Thr Lys Cys Pro Asn Gln Arg Leu Asn Leu Ala Ile Phe 25 30 35 gga gtc cat ctc atc ctc ata ggc gtg ctg ctg tgc cta tcc ctt aag 259 Gly Val His Leu Ile Leu Ile Gly Val Leu Leu Cys Leu Ser Leu Lys 40 45 50 gtt cct acg atc atc ggc acc cta gcg gtc atc aca ggc ata gga tat 307 Val Pro Thr Ile Ile Gly Thr Leu Ala Val Ile Thr Gly Ile Gly Tyr 55 60 65 tta gtc gat gca gtg gca gtg ctc cta ggc tcc cca aat cct ggc att 355 Leu Val Asp Ala Val Ala Val Leu Leu Gly Ser Pro Asn Pro Gly Ile 70 75 80 85 tct gag ttc aca ttc gtg ggc gaa gtg gtt ctg ttt atc tgg ctg atc 403 Ser Glu Phe Thr Phe Val Gly Glu Val Val Leu Phe Ile Trp Leu Ile 90 95 100 tac tcc gga gtt acc gtt ccg aag gag gaa agg cca tgc taacgagact 452 Tyr Ser Gly Val Thr Val Pro Lys Glu Glu Arg Pro Cys 105 110 ttaaccgtta ctatgtagga 472 <210> 402 <211> 114 <212> PRT <213> Corynebacterium glutamicum <400> 402 Val Ile Cys Gly Tyr Cys Cys Leu Ala Tyr Gln Ser Thr Gln Gln His 1 5 10 15 Ser Ala Gln Asn His Arg Gly Leu Thr Lys Cys Pro Asn Gln Arg Leu 20 25 30 Asn Leu Ala Ile Phe Gly Val His Leu Ile Leu Ile Gly Val Leu Leu 35 40 45 Cys Leu Ser Leu Lys Val Pro Thr Ile Ile Gly Thr Leu Ala Val Ile 50 55 60 Thr Gly Ile Gly Tyr Leu Val Asp Ala Val Ala Val Leu Leu Gly Ser 65 70 75 80 Pro Asn Pro Gly Ile Ser Glu Phe Thr Phe Val Gly Glu Val Val Leu 85 90 95 Phe Ile Trp Leu Ile Tyr Ser Gly Val Thr Val Pro Lys Glu Glu Arg 100 105 110 Pro Cys <210> 403 <211> 349 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(319) <223> RXA04092 <400> 403 ttctattggc caagcaagct cactggggtg agcatggtga caagacaatg caggtagccg 60 atgcagctgc cgaaattaac gatgaagggg aggaacgccg atg atc ttt tca gaa 115 Met Ile Phe Ser Glu 1 5 gag att ctc cat acc gac tgg ttc gca gca ctt gct gct ttc gtc gcg 163 Glu Ile Leu His Thr Asp Trp Phe Ala Ala Leu Ala Ala Phe Val Ala 10 15 20 att aac aca aca atc tat gtg gtt ctt gct att gcc aag acg ctg ccg 211 Ile Asn Thr Thr Ile Tyr Val Val Leu Ala Ile Ala Lys Thr Leu Pro 25 30 35 aag att tat gtc act gac tac tta ccg cgg aat tat gag cgt gct gag 259 Lys Ile Tyr Val Thr Asp Tyr Leu Pro Arg Asn Tyr Glu Arg Ala Glu 40 45 50 aca cgc agc att tat cca gac gtt gaa gaa ccg aaa agg aag aag tct 307 Thr Arg Ser Ile Tyr Pro Asp Val Glu Glu Pro Lys Arg Lys Lys Ser 55 60 65 gag aag aag gat tagggcggat aacgaatgcg cacggcttca 349 Glu Lys Lys Asp 70 <210> 404 <211> 73 <212> PRT <213> Corynebacterium glutamicum <400> 404 Met Ile Phe Ser Glu Glu Ile Leu His Thr Asp Trp Phe Ala Ala Leu 1 5 10 15 Ala Ala Phe Val Ala Ile Asn Thr Thr Ile Tyr Val Val Leu Ala Ile 20 25 30 Ala Lys Thr Leu Pro Lys Ile Tyr Val Thr Asp Tyr Leu Pro Arg Asn 35 40 45 Tyr Glu Arg Ala Glu Thr Arg Ser Ile Tyr Pro Asp Val Glu Glu Pro 50 55 60 Lys Arg Lys Lys Ser Glu Lys Lys Asp 65 70 <210> 405 <211> 385 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(355) <223> RXA04095 <400> 405 ctgtgcctcc tagcgatgag tagggagttg gattatttac gcttcatcgc tggggtggtc 60 ggacatactt gtgctggcat ccacattact gtgagacctc gtg cct cct ggg ccg 115 Val Pro Pro Gly Pro 1 5 ggt cag gtt cct att agc agt ttg agt atg tca ctg tct tcg gcg gca 163 Gly Gln Val Pro Ile Ser Ser Leu Ser Met Ser Leu Ser Ser Ala Ala 10 15 20 tca ccc ccc gga tca ttt tca gac agg gac agg aat aaa cca tac cga 211 Ser Pro Pro Gly Ser Phe Ser Asp Arg Asp Arg Asn Lys Pro Tyr Arg 25 30 35 agc cag cga cta gtt cca ctg tcc ttt cgg acg gcg gga acg gac ata 259 Ser Gln Arg Leu Val Pro Leu Ser Phe Arg Thr Ala Gly Thr Asp Ile 40 45 50 aac ata gtc cgc cct ctc ggg tgg acg gac tat gaa tct tcg gtg ccc 307 Asn Ile Val Arg Pro Leu Gly Trp Thr Asp Tyr Glu Ser Ser Val Pro 55 60 65 tgg ggt gga act gct aac aac gta atg ggc agg ccc aaa aga ata ctt 355 Trp Gly Gly Thr Ala Asn Asn Val Met Gly Arg Pro Lys Arg Ile Leu 70 75 80 85 taaaaggata agatttatat gacagcctga 385 <210> 406 <211> 85 <212> PRT <213> Corynebacterium glutamicum <400> 406 Val Pro Pro Gly Pro Gly Gln Val Pro Ile Ser Ser Leu Ser Met Ser 1 5 10 15 Leu Ser Ser Ala Ala Ser Pro Pro Gly Ser Phe Ser Asp Arg Asp Arg 20 25 30 Asn Lys Pro Tyr Arg Ser Gln Arg Leu Val Pro Leu Ser Phe Arg Thr 35 40 45 Ala Gly Thr Asp Ile Asn Ile Val Arg Pro Leu Gly Trp Thr Asp Tyr 50 55 60 Glu Ser Ser Val Pro Trp Gly Gly Thr Ala Asn Asn Val Met Gly Arg 65 70 75 80 Pro Lys Arg Ile Leu 85 <210> 407 <211> 310 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(280) <223> RXA04101 <400> 407 ggcgtccaat gacccgatca gtccttttga tgccaatgag gatgcatcac gcttccctac 60 cgtggcaatc accaatcctg aagctaagga gtcctaaatc atg gga act act gca 115 Met Gly Thr Thr Ala 1 5 atc atc atg atg gtg ttg ttc atg gtc atc att tgg ggt ggc ctg gtt 163 Ile Ile Met Met Val Leu Phe Met Val Ile Ile Trp Gly Gly Leu Val 10 15 20 tat gcc acc atc gca ctt cga cgc gaa cca gat gag aag gtt gga ctg 211 Tyr Ala Thr Ile Ala Leu Arg Arg Glu Pro Asp Glu Lys Val Gly Leu 25 30 35 ttt gga acc tct cca tat gcc acc gac tct gtt ctt att gag caa gag 259 Phe Gly Thr Ser Pro Tyr Ala Thr Asp Ser Val Leu Ile Glu Gln Glu 40 45 50 tct gaa cga cct gca acg gcc taaagatctc tgtaggaaac actcccgcca 310 Ser Glu Arg Pro Ala Thr Ala 55 60 <210> 408 <211> 60 <212> PRT <213> Corynebacterium glutamicum <400> 408 Met Gly Thr Thr Ala Ile Ile Met Met Val Leu Phe Met Val Ile Ile 1 5 10 15 Trp Gly Gly Leu Val Tyr Ala Thr Ile Ala Leu Arg Arg Glu Pro Asp 20 25 30 Glu Lys Val Gly Leu Phe Gly Thr Ser Pro Tyr Ala Thr Asp Ser Val 35 40 45 Leu Ile Glu Gln Glu Ser Glu Arg Pro Ala Thr Ala 50 55 60 <210> 409 <211> 382 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(352) <223> RXA04169 <400> 409 tcccagggtg gttgaccact caagcatgca agcgtcacaa atattccgga cattctgact 60 aatttcccta gagctgtaga cagcagtcct gatgaatcaa atg aaa cgc ctt atc 115 Met Lys Arg Leu Ile 1 5 tct gtc gtt ggg act aca ttt atc ttt gca act agc tgc tca gca acc 163 Ser Val Val Gly Thr Thr Phe Ile Phe Ala Thr Ser Cys Ser Ala Thr 10 15 20 gat tcc gag gtt gat tcg cca gct ccg aca agt gga gtt aca gtc tct 211 Asp Ser Glu Val Asp Ser Pro Ala Pro Thr Ser Gly Val Thr Val Ser 25 30 35 tca att atc aga tct ttt gaa ccc aat aga aaa gaa gaa ctc ctt aac 259 Ser Ile Ile Arg Ser Phe Glu Pro Asn Arg Lys Glu Glu Leu Leu Asn 40 45 50 aag ctc gta agg ttg gct cct gta aac caa gtc aat cca cgc aga gct 307 Lys Leu Val Arg Leu Ala Pro Val Asn Gln Val Asn Pro Arg Arg Ala 55 60 65 tcc cgt atc agg aaa tta cga ttt ccc aac tcc agt cga cct agg 352 Ser Arg Ile Arg Lys Leu Arg Phe Pro Asn Ser Ser Arg Pro Arg 70 75 80 tgagccagat tccgctgaga tctacacaga 382 <210> 410 <211> 84 <212> PRT <213> Corynebacterium glutamicum <400> 410 Met Lys Arg Leu Ile Ser Val Val Gly Thr Thr Phe Ile Phe Ala Thr 1 5 10 15 Ser Cys Ser Ala Thr Asp Ser Glu Val Asp Ser Pro Ala Pro Thr Ser 20 25 30 Gly Val Thr Val Ser Ser Ile Ile Arg Ser Phe Glu Pro Asn Arg Lys 35 40 45 Glu Glu Leu Leu Asn Lys Leu Val Arg Leu Ala Pro Val Asn Gln Val 50 55 60 Asn Pro Arg Arg Ala Ser Arg Ile Arg Lys Leu Arg Phe Pro Asn Ser 65 70 75 80 Ser Arg Pro Arg <210> 411 <211> 451 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(421) <223> RXA04172 <400> 411 catgatggtt tgggaaacgt tgtgaatatt gacatctagc tcagccaacg cggtggaaac 60 tgcggcgata attccggtgt ggtcctgccc tgtgacagtc atg att gca aac atg 115 Met Ile Ala Asn Met 1 5 ggt tca tgc tac aac gag cgg tgg aca cga cac ttt ggg tct atc att 163 Gly Ser Cys Tyr Asn Glu Arg Trp Thr Arg His Phe Gly Ser Ile Ile 10 15 20 tgg ggt atg cca act cta ttt aat cgc tcg tcc aag aca tat aaa tca 211 Trp Gly Met Pro Thr Leu Phe Asn Arg Ser Ser Lys Thr Tyr Lys Ser 25 30 35 ttg cac gct gat tgg ttg gat ttg ccc act gaa ctg cgt ttt cca gtc 259 Leu His Ala Asp Trp Leu Asp Leu Pro Thr Glu Leu Arg Phe Pro Val 40 45 50 att gct gtc gcg gtc gca gaa ttt gcc acc aaa gtg tcc gtg tgg gtg 307 Ile Ala Val Ala Val Ala Glu Phe Ala Thr Lys Val Ser Val Trp Val 55 60 65 tcg ctg agt cgg cgc gca cct gaa aaa gtc cgc ggc ccc aaa tgg gta 355 Ser Leu Ser Arg Arg Ala Pro Glu Lys Val Arg Gly Pro Lys Trp Val 70 75 80 85 tgg gcg ctt ttg acc atc gtc aat ggt gtt ggc ccc gct gcc tac tgg 403 Trp Ala Leu Leu Thr Ile Val Asn Gly Val Gly Pro Ala Ala Tyr Trp 90 95 100 gct ttc ggc agg aaa aac taagagttgt tagggtggcg ctcatgacta 451 Ala Phe Gly Arg Lys Asn 105 <210> 412 <211> 107 <212> PRT <213> Corynebacterium glutamicum <400> 412 Met Ile Ala Asn Met Gly Ser Cys Tyr Asn Glu Arg Trp Thr Arg His 1 5 10 15 Phe Gly Ser Ile Ile Trp Gly Met Pro Thr Leu Phe Asn Arg Ser Ser 20 25 30 Lys Thr Tyr Lys Ser Leu His Ala Asp Trp Leu Asp Leu Pro Thr Glu 35 40 45 Leu Arg Phe Pro Val Ile Ala Val Ala Val Ala Glu Phe Ala Thr Lys 50 55 60 Val Ser Val Trp Val Ser Leu Ser Arg Arg Ala Pro Glu Lys Val Arg 65 70 75 80 Gly Pro Lys Trp Val Trp Ala Leu Leu Thr Ile Val Asn Gly Val Gly 85 90 95 Pro Ala Ala Tyr Trp Ala Phe Gly Arg Lys Asn 100 105 <210> 413 <211> 481 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(451) <223> RXA04181 <400> 413 tggtttcgtc gatgaatact gttgttactg cgtgagctgg tgatgagcca gaatcaggtg 60 actggaatgc ctgtggttca cgcttagggg atgattcaca atg aag aag cca act 115 Met Lys Lys Pro Thr 1 5 cta tat tta aat ctc gaa tat gga atc cga aac tcg ctg tgg gcg gac 163 Leu Tyr Leu Asn Leu Glu Tyr Gly Ile Arg Asn Ser Leu Trp Ala Asp 10 15 20 aag gtg cca ttt ccg agg aaa ggg gta cgg ttt gtg acg tat cct gat 211 Lys Val Pro Phe Pro Arg Lys Gly Val Arg Phe Val Thr Tyr Pro Asp 25 30 35 gaa tta ggt tta tcg aac gag ttg agt gaa aaa atc cag ctg tgg act 259 Glu Leu Gly Leu Ser Asn Glu Leu Ser Glu Lys Ile Gln Leu Trp Thr 40 45 50 cgc tac tgg tta gca aat ttt gtt gat gtc gaa gat gct ccc aaa ggg 307 Arg Tyr Trp Leu Ala Asn Phe Val Asp Val Glu Asp Ala Pro Lys Gly 55 60 65 cgt ccg cag tgg aaa gct gga tct gat gtt gag tcg tgg gta gcg caa 355 Arg Pro Gln Trp Lys Ala Gly Ser Asp Val Glu Ser Trp Val Ala Gln 70 75 80 85 ggt gac att att gaa agc gcg ctc cgt gca gaa ttg cct gat ttt gcg 403 Gly Asp Ile Ile Glu Ser Ala Leu Arg Ala Glu Leu Pro Asp Phe Ala 90 95 100 gtg ttc tca aaa tgg aga ttt tat gga ctc aat gtt cgt ttt gtg caa 451 Val Phe Ser Lys Trp Arg Phe Tyr Gly Leu Asn Val Arg Phe Val Gln 105 110 115 taaagtacgt ctttgaagtt gtaagtccaa 481 <210> 414 <211> 117 <212> PRT <213> Corynebacterium glutamicum <400> 414 Met Lys Lys Pro Thr Leu Tyr Leu Asn Leu Glu Tyr Gly Ile Arg Asn 1 5 10 15 Ser Leu Trp Ala Asp Lys Val Pro Phe Pro Arg Lys Gly Val Arg Phe 20 25 30 Val Thr Tyr Pro Asp Glu Leu Gly Leu Ser Asn Glu Leu Ser Glu Lys 35 40 45 Ile Gln Leu Trp Thr Arg Tyr Trp Leu Ala Asn Phe Val Asp Val Glu 50 55 60 Asp Ala Pro Lys Gly Arg Pro Gln Trp Lys Ala Gly Ser Asp Val Glu 65 70 75 80 Ser Trp Val Ala Gln Gly Asp Ile Ile Glu Ser Ala Leu Arg Ala Glu 85 90 95 Leu Pro Asp Phe Ala Val Phe Ser Lys Trp Arg Phe Tyr Gly Leu Asn 100 105 110 Val Arg Phe Val Gln 115 <210> 415 <211> 307 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(277) <223> RXA04319 <400> 415 tgtcggataa ccaggctcct gcggagttga agccgaagaa gtcttgagtt ttctgaaggc 60 tttctggagg ttttagagag aatcagcgcc cgggagctgt ttg gga ctc tcc tgg 115 Leu Gly Leu Ser Trp 1 5 gcg ctg att ttt gtt att tca ggg tgg ttt tcg ggt tta ttg tgg cct 163 Ala Leu Ile Phe Val Ile Ser Gly Trp Phe Ser Gly Leu Leu Trp Pro 10 15 20 ggg tat gcc ccg agt agg ccg atg tgc aag ggc gac tcc gca gaa ccg 211 Gly Tyr Ala Pro Ser Arg Pro Met Cys Lys Gly Asp Ser Ala Glu Pro 25 30 35 gac agg cgt gct aaa atg tcg aat ttt cag cac atc ttg gca cat gtg 259 Asp Arg Arg Ala Lys Met Ser Asn Phe Gln His Ile Leu Ala His Val 40 45 50 tct ggt ttc aag ctc tca taaccggaca cacgtgccaa aacctacgga 307 Ser Gly Phe Lys Leu Ser 55 <210> 416 <211> 59 <212> PRT <213> Corynebacterium glutamicum <400> 416 Leu Gly Leu Ser Trp Ala Leu Ile Phe Val Ile Ser Gly Trp Phe Ser 1 5 10 15 Gly Leu Leu Trp Pro Gly Tyr Ala Pro Ser Arg Pro Met Cys Lys Gly 20 25 30 Asp Ser Ala Glu Pro Asp Arg Arg Ala Lys Met Ser Asn Phe Gln His 35 40 45 Ile Leu Ala His Val Ser Gly Phe Lys Leu Ser 50 55 <210> 417 <211> 349 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(319) <223> RXA04337 <400> 417 ggcatctgtg actggtttcg aggtcttgaa accaaaccac gatgcccacg aatcatgaaa 60 atggatttgg tgggcaccgt ggtttgatcg cggcactcga atg ctg aat cag gcg 115 Met Leu Asn Gln Ala 1 5 ggg ctc ggg cca gac cag tgg gac aaa gaa tct gaa aat ccg aca tct 163 Gly Leu Gly Pro Asp Gln Trp Asp Lys Glu Ser Glu Asn Pro Thr Ser 10 15 20 ttg tca cat gtg cca ggt ttt gcg gag ttg aag agc cgc gga cac ccc 211 Leu Ser His Val Pro Gly Phe Ala Glu Leu Lys Ser Arg Gly His Pro 25 30 35 tcc cag ccc aag cga gca tgc aaa aag ctg cgc acc cca cct aaa caa 259 Ser Gln Pro Lys Arg Ala Cys Lys Lys Leu Arg Thr Pro Pro Lys Gln 40 45 50 acc gga aaa ccg gaa tcg cag gga tgc gca gct ctt aat tta caa aag 307 Thr Gly Lys Pro Glu Ser Gln Gly Cys Ala Ala Leu Asn Leu Gln Lys 55 60 65 act tat gcc ttg tagcggtcga ttgcctcagc gtggatcttt 349 Thr Tyr Ala Leu 70 <210> 418 <211> 73 <212> PRT <213> Corynebacterium glutamicum <400> 418 Met Leu Asn Gln Ala Gly Leu Gly Pro Asp Gln Trp Asp Lys Glu Ser 1 5 10 15 Glu Asn Pro Thr Ser Leu Ser His Val Pro Gly Phe Ala Glu Leu Lys 20 25 30 Ser Arg Gly His Pro Ser Gln Pro Lys Arg Ala Cys Lys Lys Leu Arg 35 40 45 Thr Pro Pro Lys Gln Thr Gly Lys Pro Glu Ser Gln Gly Cys Ala Ala 50 55 60 Leu Asn Leu Gln Lys Thr Tyr Ala Leu 65 70 <210> 419 <211> 313 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(283) <223> RXA04352 <400> 419 gcgctagaaa cttgtcccga ggggctgggt tggtgtgcac actgctgtgg ctttgtgtgt 60 gcacaaccta gtgggatagg gcgtgcacaa ggatatgaca ttg ggt gtg cac aac 115 Leu Gly Val His Asn 1 5 gtg ctg aca ctt tac aag ggg aaa cca gac agg cgt gac aaa aat cta 163 Val Leu Thr Leu Tyr Lys Gly Lys Pro Asp Arg Arg Asp Lys Asn Leu 10 15 20 gat ttc cgc cag gtt ttg gca cgc ctg tcc ggt tta ggg gat tgg aaa 211 Asp Phe Arg Gln Val Leu Ala Arg Leu Ser Gly Leu Gly Asp Trp Lys 25 30 35 ccg gac aca cgt gac aga act tcg agt ttt tcg cca atc ttg tca cgc 259 Pro Asp Thr Arg Asp Arg Thr Ser Ser Phe Ser Pro Ile Leu Ser Arg 40 45 50 ctg tct ggt ttg cct cga gaa ggg tgattcacgg ccaagacttc taaaagttcg 313 Leu Ser Gly Leu Pro Arg Glu Gly 55 60 <210> 420 <211> 61 <212> PRT <213> Corynebacterium glutamicum <400> 420 Leu Gly Val His Asn Val Leu Thr Leu Tyr Lys Gly Lys Pro Asp Arg 1 5 10 15 Arg Asp Lys Asn Leu Asp Phe Arg Gln Val Leu Ala Arg Leu Ser Gly 20 25 30 Leu Gly Asp Trp Lys Pro Asp Thr Arg Asp Arg Thr Ser Ser Phe Ser 35 40 45 Pro Ile Leu Ser Arg Leu Ser Gly Leu Pro Arg Glu Gly 50 55 60 <210> 421 <211> 322 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(292) <223> RXA04354 <400> 421 gtaaccgatg ttctgggagg gctgcggttg gaggtaaagc ctcatcgtgg caagtctagc 60 gataccttaa gcttttttaa accttttaca acagacgttc ttg ctt ctt tac aac 115 Leu Leu Leu Tyr Asn 1 5 aat cac ttt aag gag atc act atg ttt gat cag ttc cag cag ttc acc 163 Asn His Phe Lys Glu Ile Thr Met Phe Asp Gln Phe Gln Gln Phe Thr 10 15 20 gac att gca cag aac ttc cag ggc gca cag tgg ggt gtc cag att cag 211 Asp Ile Ala Gln Asn Phe Gln Gly Ala Gln Trp Gly Val Gln Ile Gln 25 30 35 gag cag ttc cag cag cac ttc cag aat tgg ttt aac acc gaa act gta 259 Glu Gln Phe Gln Gln His Phe Gln Asn Trp Phe Asn Thr Glu Thr Val 40 45 50 gag cca gcc aag agc act ttc tcc ctc agc tcc tagtcgctct ttaaggtcaa 312 Glu Pro Ala Lys Ser Thr Phe Ser Leu Ser Ser 55 60 tgtttcacgt 322 <210> 422 <211> 64 <212> PRT <213> Corynebacterium glutamicum <400> 422 Leu Leu Leu Tyr Asn Asn His Phe Lys Glu Ile Thr Met Phe Asp Gln 1 5 10 15 Phe Gln Gln Phe Thr Asp Ile Ala Gln Asn Phe Gln Gly Ala Gln Trp 20 25 30 Gly Val Gln Ile Gln Glu Gln Phe Gln Gln His Phe Gln Asn Trp Phe 35 40 45 Asn Thr Glu Thr Val Glu Pro Ala Lys Ser Thr Phe Ser Leu Ser Ser 50 55 60 <210> 423 <211> 436 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(406) <223> RXA04370 <400> 423 cgtcaccctt gtccttgcgg acaacctcga ggaatttatc cagggacggg gcaacagtgc 60 gctcatcctg agaaggatcg agaatgatca taagttcgta ttg acg cac gga cct 115 Leu Thr His Gly Pro 1 5 cat cac ctc cta tgg tct agt aat tgt ttt ttc ggc cat gcc gtc gtt 163 His His Leu Leu Trp Ser Ser Asn Cys Phe Phe Gly His Ala Val Val 10 15 20 ggc ata gca gga ggg tcg ttg cgt cag caa cct att caa ggt aca cca 211 Gly Ile Ala Gly Gly Ser Leu Arg Gln Gln Pro Ile Gln Gly Thr Pro 25 30 35 aac gcg cgg aaa tgt cga ttc ctg att tat gcg ttt tcg ttc aca gtt 259 Asn Ala Arg Lys Cys Arg Phe Leu Ile Tyr Ala Phe Ser Phe Thr Val 40 45 50 ccc gca tgg aag tta tgc tct gct tcc agc ggc ctc gct tca gcg gtg 307 Pro Ala Trp Lys Leu Cys Ser Ala Ser Ser Gly Leu Ala Ser Ala Val 55 60 65 gag atg ctt gcc aac gtc aaa gct gaa gcc gcg agc atg cct aca aag 355 Glu Met Leu Ala Asn Val Lys Ala Glu Ala Ala Ser Met Pro Thr Lys 70 75 80 85 gtg gtt gaa gtc tta gat ttt ttc atc tgt tac ctg cct ttc tac ctt 403 Val Val Glu Val Leu Asp Phe Phe Ile Cys Tyr Leu Pro Phe Tyr Leu 90 95 100 cct taacgcactt agttagagga aagttcccac 436 Pro <210> 424 <211> 102 <212> PRT <213> Corynebacterium glutamicum <400> 424 Leu Thr His Gly Pro His His Leu Leu Trp Ser Ser Asn Cys Phe Phe 1 5 10 15 Gly His Ala Val Val Gly Ile Ala Gly Gly Ser Leu Arg Gln Gln Pro 20 25 30 Ile Gln Gly Thr Pro Asn Ala Arg Lys Cys Arg Phe Leu Ile Tyr Ala 35 40 45 Phe Ser Phe Thr Val Pro Ala Trp Lys Leu Cys Ser Ala Ser Ser Gly 50 55 60 Leu Ala Ser Ala Val Glu Met Leu Ala Asn Val Lys Ala Glu Ala Ala 65 70 75 80 Ser Met Pro Thr Lys Val Val Glu Val Leu Asp Phe Phe Ile Cys Tyr 85 90 95 Leu Pro Phe Tyr Leu Pro 100 <210> 425 <211> 1321 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1291) <223> RXA04546 <400> 425 aaactacgtt ggtagcaccg cggcgaagat aacttgcacc ggaattatgc gtggttacaa 60 gacgtgccaa atccatggga atcgtgctgt tcagtagctg ttg gta cac acc gac 115 Leu Val His Thr Asp 1 5 cgc gtc agc atc cat agg gcc aag aat ggt gta cga cgc acg cgg aaa 163 Arg Val Ser Ile His Arg Ala Lys Asn Gly Val Arg Arg Thr Arg Lys 10 15 20 cat att aaa acc atc tgt att aag cat ccc atc ggc aga tcc gta cag 211 His Ile Lys Thr Ile Cys Ile Lys His Pro Ile Gly Arg Ser Val Gln 25 30 35 ata agc cac tcg ccc acc gcg tta tct gat gcg gaa aac aat gct gaa 259 Ile Ser His Ser Pro Thr Ala Leu Ser Asp Ala Glu Asn Asn Ala Glu 40 45 50 ctc acc act gca cag att ctg cac att gac ccc gtc acc ggt gtg gcc 307 Leu Thr Thr Ala Gln Ile Leu His Ile Asp Pro Val Thr Gly Val Ala 55 60 65 atc cca cgt caa aac att ctg ctg ggt gag gat ttt cag act atg gcc 355 Ile Pro Arg Gln Asn Ile Leu Leu Gly Glu Asp Phe Gln Thr Met Ala 70 75 80 85 agc tct ttt agt caa atc cgc cat gga tgg ggt atc acc cag ctc atc 403 Ser Ser Phe Ser Gln Ile Arg His Gly Trp Gly Ile Thr Gln Leu Ile 90 95 100 gga caa gac ccc aac aga aac caa cca atc cgc tct gct gat acg tgg 451 Gly Gln Asp Pro Asn Arg Asn Gln Pro Ile Arg Ser Ala Asp Thr Trp 105 110 115 aca gtg act gga tcg act gga ctc acc ggc ttt aat act gct acg cat 499 Thr Val Thr Gly Ser Thr Gly Leu Thr Gly Phe Asn Thr Ala Thr His 120 125 130 aat aca gat gac aca gac gcc act gcc gca tat acc atg ccg gca agc 547 Asn Thr Asp Asp Thr Asp Ala Thr Ala Ala Tyr Thr Met Pro Ala Ser 135 140 145 gat cct gcc gta gga cta tgc gca ctg gaa tcc aac aaa gac gca ccg 595 Asp Pro Ala Val Gly Leu Cys Ala Leu Glu Ser Asn Lys Asp Ala Pro 150 155 160 165 gtg gat gaa ttt cgc gat ctc agc ctc agt gct tta cgt acc gct acg 643 Val Asp Glu Phe Arg Asp Leu Ser Leu Ser Ala Leu Arg Thr Ala Thr 170 175 180 gtc atg tca agc tct ggc tcc gcc gtg att act atg cat gat cct atg 691 Val Met Ser Ser Ser Gly Ser Ala Val Ile Thr Met His Asp Pro Met 185 190 195 gtc atg agc acc act ggc gca ttg gaa gca cgt gca tac gtt gac ggc 739 Val Met Ser Thr Thr Gly Ala Leu Glu Ala Arg Ala Tyr Val Asp Gly 200 205 210 gaa gtc atc aac cag cac gat ctt gac tca ctg cgt gac cag cta ggt 787 Glu Val Ile Asn Gln His Asp Leu Asp Ser Leu Arg Asp Gln Leu Gly 215 220 225 att act aca gac agc gca gat acc acc cct gcc cta cct gct gat ccc 835 Ile Thr Thr Asp Ser Ala Asp Thr Thr Pro Ala Leu Pro Ala Asp Pro 230 235 240 245 ttg gca gca ttg ggc ttg agc aca cca act aca tca gct ctt gtc cca 883 Leu Ala Ala Leu Gly Leu Ser Thr Pro Thr Thr Ser Ala Leu Val Pro 250 255 260 ggt ctt gcc gag ctg gac tgc ctc aac act gat caa gct cgc acc tgg 931 Gly Leu Ala Glu Leu Asp Cys Leu Asn Thr Asp Gln Ala Arg Thr Trp 265 270 275 cat gac cgt gac aac agc att ggc act ggt aaa cca gct att ctt gcc 979 His Asp Arg Asp Asn Ser Ile Gly Thr Gly Lys Pro Ala Ile Leu Ala 280 285 290 gtg att aac gcc gag ctc gct gat gat tac acc ctg cag atc ctc aaa 1027 Val Ile Asn Ala Glu Leu Ala Asp Asp Tyr Thr Leu Gln Ile Leu Lys 295 300 305 aat agc act gcg acc ccc acc gac tcc acc gac tcc agc gat act gct 1075 Asn Ser Thr Ala Thr Pro Thr Asp Ser Thr Asp Ser Ser Asp Thr Ala 310 315 320 325 gaa cgc ttc gta gcg cag cta cct gcg gaa aca gcc ttt gtg ctt att 1123 Glu Arg Phe Val Ala Gln Leu Pro Ala Glu Thr Ala Phe Val Leu Ile 330 335 340 gat ccg gac atc ggc gct gtg acc gat ctg ttc ttt atc aac agc ata 1171 Asp Pro Asp Ile Gly Ala Val Thr Asp Leu Phe Phe Ile Asn Ser Ile 345 350 355 aat cag gat ctc ccc gca ccg aca acc cag atc aac tca gta gcg gta 1219 Asn Gln Asp Leu Pro Ala Pro Thr Thr Gln Ile Asn Ser Val Ala Val 360 365 370 gat caa cgt gac ccc aac atc atc tac gcg acc ttt gcc aat gat gac 1267 Asp Gln Arg Asp Pro Asn Ile Ile Tyr Ala Thr Phe Ala Asn Asp Asp 375 380 385 cgc gtg tac cag ctc atg ctg ggt taaccgcgac ccgtttttat ctgtgctgat 1321 Arg Val Tyr Gln Leu Met Leu Gly 390 395 <210> 426 <211> 397 <212> PRT <213> Corynebacterium glutamicum <400> 426 Leu Val His Thr Asp Arg Val Ser Ile His Arg Ala Lys Asn Gly Val 1 5 10 15 Arg Arg Thr Arg Lys His Ile Lys Thr Ile Cys Ile Lys His Pro Ile 20 25 30 Gly Arg Ser Val Gln Ile Ser His Ser Pro Thr Ala Leu Ser Asp Ala 35 40 45 Glu Asn Asn Ala Glu Leu Thr Thr Ala Gln Ile Leu His Ile Asp Pro 50 55 60 Val Thr Gly Val Ala Ile Pro Arg Gln Asn Ile Leu Leu Gly Glu Asp 65 70 75 80 Phe Gln Thr Met Ala Ser Ser Phe Ser Gln Ile Arg His Gly Trp Gly 85 90 95 Ile Thr Gln Leu Ile Gly Gln Asp Pro Asn Arg Asn Gln Pro Ile Arg 100 105 110 Ser Ala Asp Thr Trp Thr Val Thr Gly Ser Thr Gly Leu Thr Gly Phe 115 120 125 Asn Thr Ala Thr His Asn Thr Asp Asp Thr Asp Ala Thr Ala Ala Tyr 130 135 140 Thr Met Pro Ala Ser Asp Pro Ala Val Gly Leu Cys Ala Leu Glu Ser 145 150 155 160 Asn Lys Asp Ala Pro Val Asp Glu Phe Arg Asp Leu Ser Leu Ser Ala 165 170 175 Leu Arg Thr Ala Thr Val Met Ser Ser Ser Gly Ser Ala Val Ile Thr 180 185 190 Met His Asp Pro Met Val Met Ser Thr Thr Gly Ala Leu Glu Ala Arg 195 200 205 Ala Tyr Val Asp Gly Glu Val Ile Asn Gln His Asp Leu Asp Ser Leu 210 215 220 Arg Asp Gln Leu Gly Ile Thr Thr Asp Ser Ala Asp Thr Thr Pro Ala 225 230 235 240 Leu Pro Ala Asp Pro Leu Ala Ala Leu Gly Leu Ser Thr Pro Thr Thr 245 250 255 Ser Ala Leu Val Pro Gly Leu Ala Glu Leu Asp Cys Leu Asn Thr Asp 260 265 270 Gln Ala Arg Thr Trp His Asp Arg Asp Asn Ser Ile Gly Thr Gly Lys 275 280 285 Pro Ala Ile Leu Ala Val Ile Asn Ala Glu Leu Ala Asp Asp Tyr Thr 290 295 300 Leu Gln Ile Leu Lys Asn Ser Thr Ala Thr Pro Thr Asp Ser Thr Asp 305 310 315 320 Ser Ser Asp Thr Ala Glu Arg Phe Val Ala Gln Leu Pro Ala Glu Thr 325 330 335 Ala Phe Val Leu Ile Asp Pro Asp Ile Gly Ala Val Thr Asp Leu Phe 340 345 350 Phe Ile Asn Ser Ile Asn Gln Asp Leu Pro Ala Pro Thr Thr Gln Ile 355 360 365 Asn Ser Val Ala Val Asp Gln Arg Asp Pro Asn Ile Ile Tyr Ala Thr 370 375 380 Phe Ala Asn Asp Asp Arg Val Tyr Gln Leu Met Leu Gly 385 390 395 <210> 427 <211> 829 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(799) <223> RXA04549 <400> 427 cgtttcgatc atttgtaaca ttcttattac aagactggaa ataaaggtga gtcaatcata 60 cagtcagatg tggtcatcgg caaaacagaa aggaatcccg atg tta cga aaa aca 115 Met Leu Arg Lys Thr 1 5 gtt acc ggt gga att gtt gct ctt att gcg act gcc act ctc atg aat 163 Val Thr Gly Gly Ile Val Ala Leu Ile Ala Thr Ala Thr Leu Met Asn 10 15 20 tct gtc tct tct gct gaa gag gta tcc gga gat gtc tca gca gta gat 211 Ser Val Ser Ser Ala Glu Glu Val Ser Gly Asp Val Ser Ala Val Asp 25 30 35 ctc gca ttt gca gaa ttc gaa cgt aca act gca gag gac gtg gcc aat 259 Leu Ala Phe Ala Glu Phe Glu Arg Thr Thr Ala Glu Asp Val Ala Asn 40 45 50 gga gtg cca gag gct ata gct aat gca gaa aaa att tcc aat ttc act 307 Gly Val Pro Glu Ala Ile Ala Asn Ala Glu Lys Ile Ser Asn Phe Thr 55 60 65 ccg agc gaa cta gag ggc ttc aag agt ctt tta gct agt gat gca gtg 355 Pro Ser Glu Leu Glu Gly Phe Lys Ser Leu Leu Ala Ser Asp Ala Val 70 75 80 85 ctg agg tcg gtc tct gga gaa gaa att ctc cca gat aat gtt gaa gtg 403 Leu Arg Ser Val Ser Gly Glu Glu Ile Leu Pro Asp Asn Val Glu Val 90 95 100 gtt cag acg gac aac gta ggc gac gaa gat cca aat gtc att tct cca 451 Val Gln Thr Asp Asn Val Gly Asp Glu Asp Pro Asn Val Ile Ser Pro 105 110 115 gca gcc tgg cag ggt tct gat tat att gag ggg tgt tta acg aat act 499 Ala Ala Trp Gln Gly Ser Asp Tyr Ile Glu Gly Cys Leu Thr Asn Thr 120 125 130 ctc tac gga att gaa gtc cta aag gtt tgt act ggt gga acc tac tac 547 Leu Tyr Gly Ile Glu Val Leu Lys Val Cys Thr Gly Gly Thr Tyr Tyr 135 140 145 tcc aat gta gga atc gct act tct gtc agc aat cct cgc agt tac gta 595 Ser Asn Val Gly Ile Ala Thr Ser Val Ser Asn Pro Arg Ser Tyr Val 150 155 160 165 aag tat aac agt gct cca gga ttg gca gtg acg aca agc aat cca cgt 643 Lys Tyr Asn Ser Ala Pro Gly Leu Ala Val Thr Thr Ser Asn Pro Arg 170 175 180 gga ggt ata gag ggt ggt ctt gcg gcc ttc tat ggt gat gtt aac ctt 691 Gly Gly Ile Glu Gly Gly Leu Ala Ala Phe Tyr Gly Asp Val Asn Leu 185 190 195 gtt gct ttt cca aat att cca tgg gtg gga cca att agt tct tct gca 739 Val Ala Phe Pro Asn Ile Pro Trp Val Gly Pro Ile Ser Ser Ser Ala 200 205 210 gga act cac cgc gtt gtc gct aga tca ttt ccg aat tca gtg gtg ctt 787 Gly Thr His Arg Val Val Ala Arg Ser Phe Pro Asn Ser Val Val Leu 215 220 225 aac gtc tac tac taatcgtttt ttagtttgaa acactgttgt 829 Asn Val Tyr Tyr 230 <210> 428 <211> 233 <212> PRT <213> Corynebacterium glutamicum <400> 428 Met Leu Arg Lys Thr Val Thr Gly Gly Ile Val Ala Leu Ile Ala Thr 1 5 10 15 Ala Thr Leu Met Asn Ser Val Ser Ser Ala Glu Glu Val Ser Gly Asp 20 25 30 Val Ser Ala Val Asp Leu Ala Phe Ala Glu Phe Glu Arg Thr Thr Ala 35 40 45 Glu Asp Val Ala Asn Gly Val Pro Glu Ala Ile Ala Asn Ala Glu Lys 50 55 60 Ile Ser Asn Phe Thr Pro Ser Glu Leu Glu Gly Phe Lys Ser Leu Leu 65 70 75 80 Ala Ser Asp Ala Val Leu Arg Ser Val Ser Gly Glu Glu Ile Leu Pro 85 90 95 Asp Asn Val Glu Val Val Gln Thr Asp Asn Val Gly Asp Glu Asp Pro 100 105 110 Asn Val Ile Ser Pro Ala Ala Trp Gln Gly Ser Asp Tyr Ile Glu Gly 115 120 125 Cys Leu Thr Asn Thr Leu Tyr Gly Ile Glu Val Leu Lys Val Cys Thr 130 135 140 Gly Gly Thr Tyr Tyr Ser Asn Val Gly Ile Ala Thr Ser Val Ser Asn 145 150 155 160 Pro Arg Ser Tyr Val Lys Tyr Asn Ser Ala Pro Gly Leu Ala Val Thr 165 170 175 Thr Ser Asn Pro Arg Gly Gly Ile Glu Gly Gly Leu Ala Ala Phe Tyr 180 185 190 Gly Asp Val Asn Leu Val Ala Phe Pro Asn Ile Pro Trp Val Gly Pro 195 200 205 Ile Ser Ser Ser Ala Gly Thr His Arg Val Val Ala Arg Ser Phe Pro 210 215 220 Asn Ser Val Val Leu Asn Val Tyr Tyr 225 230 <210> 429 <211> 484 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(454) <223> RXA04642 <400> 429 tatttagtgg aaatttcctg ttggtgttca tcgtgacggt cttgttgacg atcccagttg 60 ccgccatcag ctacaccttc atcgaagagc ccatcatgcg gtg gac ccg gcg cgc 115 Val Asp Pro Ala Arg 1 5 cat tca ggc tgg ggg tcg tta gga ttc acc att ttt ctg ggg gta ggt 163 His Ser Gly Trp Gly Ser Leu Gly Phe Thr Ile Phe Leu Gly Val Gly 10 15 20 ctg gaa aat gat gaa ttg gca cca cgt caa gac ggg gac ggg gca tgg 211 Leu Glu Asn Asp Glu Leu Ala Pro Arg Gln Asp Gly Asp Gly Ala Trp 25 30 35 caa gcc ggt aag gga act aat ttg cta ata ctc acc aca gga tcc gga 259 Gln Ala Gly Lys Gly Thr Asn Leu Leu Ile Leu Thr Thr Gly Ser Gly 40 45 50 ttt tca gcc gtt tgt ggt gga ttt ttg caa ctc gcc ggc ggt ttt atg 307 Phe Ser Ala Val Cys Gly Gly Phe Leu Gln Leu Ala Gly Gly Phe Met 55 60 65 caa aaa tcc gtt cga ttt gaa ggt ctg gcc aca gga ttg tgg tgg atc 355 Gln Lys Ser Val Arg Phe Glu Gly Leu Ala Thr Gly Leu Trp Trp Ile 70 75 80 85 ctt gat caa caa gct gac agg aat cac agg agc ccc aat ggt cac aaa 403 Leu Asp Gln Gln Ala Asp Arg Asn His Arg Ser Pro Asn Gly His Lys 90 95 100 ttc tac cct ctc tac aat cgc ctc caa ggg cct aga atc gtc aga atg 451 Phe Tyr Pro Leu Tyr Asn Arg Leu Gln Gly Pro Arg Ile Val Arg Met 105 110 115 aac tgacacccat ttagcgcttt ggaggcctta 484 Asn <210> 430 <211> 118 <212> PRT <213> Corynebacterium glutamicum <400> 430 Val Asp Pro Ala Arg His Ser Gly Trp Gly Ser Leu Gly Phe Thr Ile 1 5 10 15 Phe Leu Gly Val Gly Leu Glu Asn Asp Glu Leu Ala Pro Arg Gln Asp 20 25 30 Gly Asp Gly Ala Trp Gln Ala Gly Lys Gly Thr Asn Leu Leu Ile Leu 35 40 45 Thr Thr Gly Ser Gly Phe Ser Ala Val Cys Gly Gly Phe Leu Gln Leu 50 55 60 Ala Gly Gly Phe Met Gln Lys Ser Val Arg Phe Glu Gly Leu Ala Thr 65 70 75 80 Gly Leu Trp Trp Ile Leu Asp Gln Gln Ala Asp Arg Asn His Arg Ser 85 90 95 Pro Asn Gly His Lys Phe Tyr Pro Leu Tyr Asn Arg Leu Gln Gly Pro 100 105 110 Arg Ile Val Arg Met Asn 115 <210> 431 <211> 790 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(760) <223> RXA06004 <400> 431 agctgcctgc aagatggcgg cggagaagat tcccgctgga tccaaggtgt atgttttggg 60 ttcagaatcc ttccgcgagc tagctactga agctggtttt gtg gtg gtt gat tcg 115 Val Val Val Asp Ser 1 5 gct gat gat aaa cct gtg gct gtg ctt cac ggc cac aac cct gag acc 163 Ala Asp Asp Lys Pro Val Ala Val Leu His Gly His Asn Pro Glu Thr 10 15 20 ggt tgg gct cag ttg agc gag gct gcg ctg tca att aat gct ggc gcg 211 Gly Trp Ala Gln Leu Ser Glu Ala Ala Leu Ser Ile Asn Ala Gly Ala 25 30 35 cag tat ttt gca tca aat ttg gat tcc acc ctt ccc atg gaa cgc ggt 259 Gln Tyr Phe Ala Ser Asn Leu Asp Ser Thr Leu Pro Met Glu Arg Gly 40 45 50 cgt cac att ggc aac ggt tcc atg gtg gct gcc gtg gtc aac gcg act 307 Arg His Ile Gly Asn Gly Ser Met Val Ala Ala Val Val Asn Ala Thr 55 60 65 ggc gta aag cct ctt tcc gca ggt aag cca ggc ccc gcg atg ttc tat 355 Gly Val Lys Pro Leu Ser Ala Gly Lys Pro Gly Pro Ala Met Phe Tyr 70 75 80 85 gcg ggg gct aaa act ctt aat tct tca aag cct ttg gct gtc ggc gat 403 Ala Gly Ala Lys Thr Leu Asn Ser Ser Lys Pro Leu Ala Val Gly Asp 90 95 100 cgt ctc gat act gat att gca ggc gga aac gct gca ggc atg gac aca 451 Arg Leu Asp Thr Asp Ile Ala Gly Gly Asn Ala Ala Gly Met Asp Thr 105 110 115 ttc cag gtc ctg acc ggc gtc agc ggc tac tac gat ttg gtg cgc gcc 499 Phe Gln Val Leu Thr Gly Val Ser Gly Tyr Tyr Asp Leu Val Arg Ala 120 125 130 att cca gag cag cgc ccc acc tat atc gcc acc tcg atg cag gat ctc 547 Ile Pro Glu Gln Arg Pro Thr Tyr Ile Ala Thr Ser Met Gln Asp Leu 135 140 145 tac agc gat ccg ggc gag ctc aag cca ggt gcc cag ggc ggt ttt tca 595 Tyr Ser Asp Pro Gly Glu Leu Lys Pro Gly Ala Gln Gly Gly Phe Ser 150 155 160 165 gcg ctt atc gac ggc gac acc ctg gtc att tcc ggc ggc gat gcc ggc 643 Ala Leu Ile Asp Gly Asp Thr Leu Val Ile Ser Gly Gly Asp Ala Gly 170 175 180 gca act ccg gtt gca gca ctc cgc act gcg ttg gat gtg gcc tgg gcg 691 Ala Thr Pro Val Ala Ala Leu Arg Thr Ala Leu Asp Val Ala Trp Ala 185 190 195 gcc aca gag cca gtc acc gag gta cgc gct gat tca gag gta gct gct 739 Ala Thr Glu Pro Val Thr Glu Val Arg Ala Asp Ser Glu Val Ala Ala 200 205 210 act gca ttg cag agc tgg tgg taaacggtga attcaccaaa gcctcatgat 790 Thr Ala Leu Gln Ser Trp Trp 215 220 <210> 432 <211> 220 <212> PRT <213> Corynebacterium glutamicum <400> 432 Val Val Val Asp Ser Ala Asp Asp Lys Pro Val Ala Val Leu His Gly 1 5 10 15 His Asn Pro Glu Thr Gly Trp Ala Gln Leu Ser Glu Ala Ala Leu Ser 20 25 30 Ile Asn Ala Gly Ala Gln Tyr Phe Ala Ser Asn Leu Asp Ser Thr Leu 35 40 45 Pro Met Glu Arg Gly Arg His Ile Gly Asn Gly Ser Met Val Ala Ala 50 55 60 Val Val Asn Ala Thr Gly Val Lys Pro Leu Ser Ala Gly Lys Pro Gly 65 70 75 80 Pro Ala Met Phe Tyr Ala Gly Ala Lys Thr Leu Asn Ser Ser Lys Pro 85 90 95 Leu Ala Val Gly Asp Arg Leu Asp Thr Asp Ile Ala Gly Gly Asn Ala 100 105 110 Ala Gly Met Asp Thr Phe Gln Val Leu Thr Gly Val Ser Gly Tyr Tyr 115 120 125 Asp Leu Val Arg Ala Ile Pro Glu Gln Arg Pro Thr Tyr Ile Ala Thr 130 135 140 Ser Met Gln Asp Leu Tyr Ser Asp Pro Gly Glu Leu Lys Pro Gly Ala 145 150 155 160 Gln Gly Gly Phe Ser Ala Leu Ile Asp Gly Asp Thr Leu Val Ile Ser 165 170 175 Gly Gly Asp Ala Gly Ala Thr Pro Val Ala Ala Leu Arg Thr Ala Leu 180 185 190 Asp Val Ala Trp Ala Ala Thr Glu Pro Val Thr Glu Val Arg Ala Asp 195 200 205 Ser Glu Val Ala Ala Thr Ala Leu Gln Ser Trp Trp 210 215 220 <210> 433 <211> 430 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(400) <223> RXA06040 <400> 433 cccgagtcta cgcaaaactg cactctgctg aacgctcatt tgaaaaaatg ggggatggtt 60 cggggtcttc atcaggggtg aaggtggtgc gcccttaggt ttg gag gga ctt cgt 115 Leu Glu Gly Leu Arg 1 5 aag att ccg gct tta ctt cgg gcg tca ctt cag gcc tgt atc gcc agt 163 Lys Ile Pro Ala Leu Leu Arg Ala Ser Leu Gln Ala Cys Ile Ala Ser 10 15 20 ttt ggc ctt ggc gcc cgc gat ttc gcc cca gac gac ctc aat tca agg 211 Phe Gly Leu Gly Ala Arg Asp Phe Ala Pro Asp Asp Leu Asn Ser Arg 25 30 35 ggg tcc aat cct aaa acc gga cta aaa cca gac tgt aaa gtg tca gca 259 Gly Ser Asn Pro Lys Thr Gly Leu Lys Pro Asp Cys Lys Val Ser Ala 40 45 50 cgt tgt gca cac tca ata tca tat cct tgc gca cgc ccg atc cca cta 307 Arg Cys Ala His Ser Ile Ser Tyr Pro Cys Ala Arg Pro Ile Pro Leu 55 60 65 ggt tgt gca cac aca aag cca cag cag tgt gca cac caa ccc tca ccc 355 Gly Cys Ala His Thr Lys Pro Gln Gln Cys Ala His Gln Pro Ser Pro 70 75 80 85 tcg gga caa gtt tct agc gca gta gat ccc ccg gat cta tcg act 400 Ser Gly Gln Val Ser Ser Ala Val Asp Pro Pro Asp Leu Ser Thr 90 95 100 taaatcgctt ctcagcctca tcacgtttgc 430 <210> 434 <211> 100 <212> PRT <213> Corynebacterium glutamicum <400> 434 Leu Glu Gly Leu Arg Lys Ile Pro Ala Leu Leu Arg Ala Ser Leu Gln 1 5 10 15 Ala Cys Ile Ala Ser Phe Gly Leu Gly Ala Arg Asp Phe Ala Pro Asp 20 25 30 Asp Leu Asn Ser Arg Gly Ser Asn Pro Lys Thr Gly Leu Lys Pro Asp 35 40 45 Cys Lys Val Ser Ala Arg Cys Ala His Ser Ile Ser Tyr Pro Cys Ala 50 55 60 Arg Pro Ile Pro Leu Gly Cys Ala His Thr Lys Pro Gln Gln Cys Ala 65 70 75 80 His Gln Pro Ser Pro Ser Gly Gln Val Ser Ser Ala Val Asp Pro Pro 85 90 95 Asp Leu Ser Thr 100

Claims (8)

  1. 표 1의 컬럼 2에 각각 나타낸 아미노산 서열을 갖는 폴리펩티드를 코딩하며, 표 1의 컬럼 4에 나타낸 아미노산 위치에서 그와 동일 열에 있는 컬럼 5에 나타낸 특정 아미노산이 아닌 단백질성 아미노산을 코딩하는 단리된 핵산 분자.
  2. 제1항에 있어서, 표 1의 컬럼 4에 나타낸 아미노산 위치에서 그와 동일 열에 있는 컬럼 6에 나타낸 아미노산을 코딩하는 단리된 핵산 분자.
  3. 제1항에 따른 하나 이상의 핵산 서열을 포함하는 벡터.
  4. 제3항에 따른 하나 이상의 벡터로 형질감염된 숙주 세포.
  5. 제4항에 있어서, 상기 핵산 분자의 발현에 의해 정밀 화학물질 (fine chemical) 생산이 조정되는 숙주 세포.
  6. 제3항에 따른 하나 이상의 벡터로 형질감염된 세포를 배양하여 정밀 화학물질이 생산되도록 하는 단계를 포함하는, 정밀 화학물질의 제조 방법.
  7. 제6항에 있어서, 정밀 화학물질이 아미노산인 방법.
  8. 제7항에 있어서, 아미노산이 리신인 방법.
KR1020047006758A 2001-11-05 2002-10-31 신규 단백질을 코딩하는 유전자 KR100868692B1 (ko)

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