KR20040058265A - 막 합성 및 막 수송 단백질을 코딩하는 유전자 - Google Patents

막 합성 및 막 수송 단백질을 코딩하는 유전자 Download PDF

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KR20040058265A
KR20040058265A KR10-2004-7006761A KR20047006761A KR20040058265A KR 20040058265 A KR20040058265 A KR 20040058265A KR 20047006761 A KR20047006761 A KR 20047006761A KR 20040058265 A KR20040058265 A KR 20040058265A
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오스카르 첼더
마르쿠스 폼페유스
하르트비히 쉬뢰더
부르크하르트 크뢰거
코린나 클로프로게
그레고르 하버하우어
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Abstract

본 발명은 신규한 핵산 분자, 유전자적으로 개선된 미생물의 제조에 있어서의 그의 용도 및 상기 유전자적으로 개선된 미생물을 사용한 정밀 화학물질, 특히 아미노산의 제조 방법에 관한 것이다.

Description

막 합성 및 막 수송 단백질을 코딩하는 유전자 {Genes Encoding for Membrane Synthesis and Membrane Transport Proteins}
세포내 천연 대사 과정의 특정 생성물 및 부산물은 식품 산업, 동물 사료 산업, 화장품 산업 및 제약 산업을 비롯한 여러 분야의 산업에 이용되고 있다. 정밀 화학물질 (fine chemical)이라고 통칭되는 이들 분자들은 유기산, 단백질원성 아미노산 및 비-단백질원성 아미노산, 뉴클레오티드 및 뉴클레오시드, 지질 및 지방산, 디올, 탄수화물, 방향족 화합물, 비타민, 보조인자 및 효소를 포함한다. 이들은 1종 이상의 분자를 다량으로 생산하고 분비하도록 개발된 박테리아를 대량 배양함으로써 최고의 생산량으로 생산된다. 이러한 목적에 특히 적합한 유기체는 비-병원성의 그람-양성 박테리아인 코리네박테리움 글루타미쿰 (Corynebacterium glutamicum)이다. 균주 선별을 통해, 각종 바람직한 화합물을 생산하는 수많은 돌연변이체 균주가 개발되어 왔다. 그러나, 특정 분자의 생산과 관련하여 개선된 균주의 선별은 시간 소모적이고 어려운 과정이다.
본 발명에 대한 간단한 설명
본 발명은 코리네박테리움 글루타미쿰 또는 그와 관련된 박테리아 종의 확인 또는 분류에 사용될 수 있는 신규 핵산 분자를 제공한다. 코리네박테리움 글루타미쿰은 수많은 정밀 화학물질의 대량 생산 및 또한 탄화수소 분해 (예를 들어 원유유출 사고의 경우) 및 테르페노이드의 산화와 관련된 산업에 광범위하게 이용되는 그람-양성 호기성 박테리아이다. 따라서, 상기 핵산 분자는 예를 들어 발효 공정에 의한 정밀 화학물질의 생산에 사용될 수 있는 미생물을 확인하는데 이용될 수 있다. 코리네박테리움 글루타미쿰 자체는 병원성이 아니지만, 코리네박테리움 디프테리애 (Corynebacterium diphtheriae) (디프테리아 병원체) 등과 같은 기타 관련 코리네박테리움 종은 인간에서의 주요 병원체이다. 따라서, 코리네박테리움 종의 존재 확인력은 예를 들어 진단 용도 등에서의 임상적 중요성이 상당할 수도 있다. 추가로, 상기 핵산 분자는 코리네박테리움 글루타미쿰 게놈 또는 그와 관련된 유기체의 게놈 맵핑을 위한 기준점으로 작용할 수도 있다.
이들 신규 핵산 분자는 본원에서 막 구성 및 막 수송 (MCT: membrane construction and membrane transport) 단백질로서 칭해지는 단백질을 코딩한다. 이들 MCT 단백질은 예를 들어, 막 생합성에 필요한 화합물의 대사 (예를 들어, 생합성 또는 분해)에 관련된 기능을 수행하거나, 세포내로 또는 세포로부터 1종 이상의 화합물의 막횡단 수송을 보조할 수 있다. 예를 들어, 미국 특허 제4,649,119호 (Sinskey et al.)에 개시된 클로닝 벡터와 같은 코리네박테리움 글루타미쿰에 사용하기 위한 클로닝 벡터, 및 코리네박테리움 글루타미쿰 및 관련된 브레비박테리움 종 (예컨대, 락토페르멘툼)의 유전 조작 기술 (Yoshihama et al, J. Bacteriol. 162 (1985) 591-597; Katsumata et al., J. Bacteriol. 159 (1984) 306-311; 및 Santamaria et al., J. Gen. Microbiol. 130 (1984) 237-2246)의 이용가능성으로 인해, 본 발명의 핵산 분자를 이 유기체가 1종 이상의 정밀 화학물질의 보다 효율적인 생산자가 되도록 상기 유기체의 유전공학적 조작에 사용할 수 있다. 본 발명의 유전자 조작은 정밀 화학물질의 생산 또는 생산 효율에 직접적으로 또는 간접적으로 영향을 줄 수 있다.
본 발명의 MCT 단백질의 변형에 의해 상기 변형된 단백질을 포함하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질의 수율, 생산 및(또는) 생산 효율에 직접적으로 영향을 줄 수 있는 여러 기작이 있다. 세포로부터의 정밀 화학물질 분자의 배출에 관여하는 이러한 MCT 단백질을, 이러한 화합물이 보다 쉽게 회수되는 세포외 매질로 더 많은 양이 분비되도록, 그의 수 또는 활성을 증가시킬 수 있다. 1종 이상의 정밀 화학물질의 생합성에 필요한 영양분 (예를 들어, 포스페이트, 술페이트, 질소 화합물 등)의 유입에 관여하는 MCT 단백질을, 이러한 전구체, 보조인자 또는 중간체 화합물의 세포내 농도가 증가되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 지방산 및 지질 자체는 바람직한 정밀 화학물질이며, 이러한 화합물의 생합성에 관여하는 1종 이상의 본 발명의 MCT 단백질의 활성을 최적화하거나 또는 그의 수를 증가시킴으로써, 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 손상시킴으로써, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
또한, 본 발명의 1종 이상의 MCT 유전자에 돌연변이를 유발시켜 코리네박테리움 글루타미쿰으로부터 1종 이상의 목적하는 정밀 화학물질을 생산하는데 간접적으로 영향을 주는, 활성이 변화된 MCT 단백질을 제조할 수 있다. 예를 들어, 폐 생성물의 배출에 관여하는 본 발명의 MCT 단백질을, 세포의 정상적인 대사성 폐기물 (목적하는 정밀 화학물질의 과다생산으로 인해 양이 증가될 수 있음)이 세포내에서 뉴클레오티드 및 단백질을 손상시키거나 (세포의 생존율이 감소됨) 또는 정밀 화학물질 생합성 경로를 방해하기 (목적하는 정밀 화학물질의 수율, 생산 또는 생산 효율이 저하됨) 전에 효과적으로 배출되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 세포내에서 비교적 다량인 정밀 화학물질은 그 자체로도 세포에 독성을 띨 수 있어서, 세포로부터 이 화합물을 배출시킬 수 있는 트랜스포터의 활성 또는 수를 증가시킴으로써, 배양물내 세포의 생존율을 증가시킬 수 있고, 또한 배양물내에서 목적하는 정밀 화학물질을 생산하는 세포수를 더 증가시킬 수 있다. 상대적 양의 다른 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을 조작할 수도 있다. 이는 세포막의 지질 조성에 상당한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가지기 때문에, 막의 지질 조성에 있어서의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성에서의 변화는 막을 통한 분자의 수송뿐 아니라 세포의 일체성에 영향을 줄 수 있으며, 이들 모두는 대규모 발효 배양에서 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 생산에 상당한 영항을 준다.
본 발명은 예를 들어 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 수송에 관여할 수 있는, 본원에서 MCT 단백질로 언급되는 단백질을 코딩하는 신규 핵산 분자를 제공한다. 바람직한 실시양태에서, MCT 단백질은 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 수송에 관여한다. 이러한 단백질의 예로는 하기 표 1의 유전자 세트에 의해 코딩되는 것들이 포함된다.
따라서, 본 발명의 한 측면은 MCT 단백질 또는 그의 생물학적 활성 절편을 코딩하는 뉴클레오티드 서열을 포함하는 단리된 핵산 분자 (예컨대 cDNA) 및 또한 MCT-코딩 핵산 (예컨대 DNA 또는 mRNA)을 검출하거나 증폭시키기 위한 프라이머 또는 혼성화 프로브로서 적합한 핵산 단편에 관한 것이다. 특히 바람직한 실시양태에서, 단리된 핵산 분자는 첨부문서 (Appendix) A에 기재한 임의의 뉴클레오티드 서열 또는 이러한 핵산 서열 중 임의의 서열의 코딩 영역 또는 그의 상보체를 포함한다. 다른 바람직한 실시양태에서, 단리된 핵산 분자는 첨부문서 B에 기재한 아미노산 서열 중 하나를 코딩한다. 또한, 본 발명의 바람직한 MCT 단백질은 본원에 기재한 MCT 활성을 바람직하게는 하나 이상 보유한다.
하기에서, 첨부문서 A는 표 1에서 해당 위치에서의 서열 변형과 함께 서열 목록의 핵산 서열을 규정한다.
하기에서, 첨부문서 B는 표 1에서 해당 위치에서의 서열 변형과 함께 서열 목록의 폴리펩티드 서열을 규정한다.
추가의 실시양태에서, 단리된 핵산 분자는 뉴클레오티드 15개 이상의 길이이며 엄격 조건하에서 첨부문서 A의 뉴클레오티드 서열을 포함하는 핵산 분자와 혼성화된다. 바람직하게는, 단리된 핵산 분자는 천연 핵산 분자에 상응한다. 더욱 바람직하게는, 단리된 핵산은 천연 코리네박테리움 글루타미쿰 MCT 단백질 또는 그의 생물학적 활성 절편을 코딩한다.
본 발명의 또다른 측면은 벡터, 예를 들어 본 발명의 핵산 분자를 함유하는재조합 발현 벡터 및 상기 벡터가 도입된 숙주 세포에 관한 것이다. 한 실시양태에서, MCT 단백질은 적합한 배지 중에서 배양한 숙주 세포를 사용하여 제조된다. 이후에, 상기 배지 또는 숙주 세포로부터 MCT 단백질을 단리할 수 있다.
본 발명의 또다른 측면은 MCT 유전자가 도입되었거나 MCT 유전자가 변형됨으로써 유전자 변형된 미생물에 관한 것이다. 한 실시양태에서, 상기 미생물의 게놈은 돌연변이된 MCT 서열을 코딩하는 1종 이상의 본 발명의 핵산 분자를 트랜스진 (transgene)으로서 도입함으로써 변형된다. 또다른 실시양태에서, 상기 미생물 게놈 내의 내인성 MCT 유전자는 변형된 MCT 유전자와의 상동성 재조합에 의해 변형, 예를 들어 기능적으로 파괴된다. 바람직한 실시양태에서, 상기 미생물은 코리네박테리움 속 또는 브레비박테리움 속에 포함되며, 코리네박테리움 글루타미쿰인 것이 특히 바람직하다. 또한, 바람직한 실시양태에서는 상기 미생물을 이용하여 아미노산, 특히 바람직하게는 리신 등과 같은 관심 화합물을 제조한다.
또다른 바람직한 실시양태는 첨부문서 A에 기재한 핵산 분자를 1종보다 많이 보유하는 숙주 세포이다. 이러한 숙주 세포는 당업자에게 공지된 여러 방법으로 제조할 수 있다. 이들은 예를 들어 본 발명의 핵산 분자를 여러개 수송하는 벡터로 형질감염될 수 있다. 그러나, 각 경우에 벡터를 이용하여 본 발명의 한 핵산 분자를 숙주 세포에 도입할 수 있기 때문에, 복수개의 벡터를 동시에 또는 순차적으로 이용할 수도 있다. 따라서, 수백 종에 이르는 수많은 본 발명의 핵산 서열을 수송하는 숙주 세포를 제작할 수 있다. 이러한 축적은 종종 숙주 세포에서 정밀 화학물질의 생산성과 관련된 부수적인 효과를 초래할 수 있다.
본 발명의 또다른 측면은 단리된 MCT 단백질 또는 그의 절편, 예를 들어 그의 생물학적 활성 절편에 관한 것이다. 바람직한 실시양태에서, 단리된 MCT 단백질 또는 그의 절편은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다. 또다른 바람직한 실시양태에서, 단리된 MCT 단백질 또는 그의 절편은 첨부문서 B의 아미노산 서열에 충분한 상동성이 있어서, 상기 단백질 또는 그의 절편이 예를 들어 여전히 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 생산량 또는 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다.
추가로, 본 발명은 단리된 MCT 단백질 제제에 관한 것이다. 바람직한 실시양태에서, MCT 단백질은 첨부문서 B의 아미노산 서열을 포함한다. 추가의 바람직한 실시양태에서, 본 발명은 첨부문서 B의 완전 아미노산 서열 (첨부문서 A의 오픈 리딩 프레임에 의해 코딩됨)에 본질적으로 상동성이 있는 단리된 전장 단백질에 관한 것이다.
MCT 폴리펩티드 또는 그의 생물학적 활성 절편은 비-MCT 폴리펩티드와 기능적으로 연결되어 융합 단백질을 형성할 수 있다. 바람직한 실시양태에서, 이 융합 단백질은 MCT 단백질 단독과는 활성이 상이하다. 다른 바람직한 실시양태에서, 상기 융합 단백질은 코리네박테리움 글루타미쿰에서 1종 이상의 정밀 화학물질의 수율, 생산량 및(또는) 생산 효율을 조정하거나 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체에 대한 확인용 마커로 작용할 수 있다. 특히 바람직한 실시양태에서, 숙주 세포로의 상기 융합 단백질 통합이 세포에 의한 관심 화합물의 생산을 조정한다.
본 발명의 또다른 측면은 정밀 화학물질의 제조 방법에 관한 것이다. 상기 방법은 본 발명의 MCT 핵산 분자를 발현시켜 정밀 화학물질이 생산되도록 하는 벡터를 함유하는 세포를 배양하는 단계를 포함한다. 바람직한 실시양태에서, 상기 방법은 MCT 핵산을 발현시키는 벡터로 형질감염되어 이러한 벡터를 함유하는 세포를 수득하는 단계를 추가로 포함한다. 추가의 바람직한 실시양태에서, 상기 방법은 배양물로부터 정밀 화학물질을 수득하는 단계를 추가로 포함한다. 특히 바람직한 실시양태에서, 상기 세포는 코리네박테리움 속 또는 브레비박테리움 속에 속한다.
본 발명의 또다른 측면은 미생물로부터의 분자 생산을 조정하는 방법에 관한 것이다. 상기 방법은 세포를 MCT 단백질 활성 또는 MCT 핵산의 발현을 조정하는 물질로서 그의 존재하에서는 세포의 관련 활성이 그의 부재하에서의 동일 활성과 비교할 때 변형되는 물질과 접촉시키는 단계를 포함한다. 바람직한 실시양태에서는, 세포막 성분에 대한 1종 이상의 코리네박테리움 글루타미쿰 대사 경로와 관련하여 세포를 조정하여, 상기 미생물에 의한 관심 정밀 화학물질의 수율 또는 생산 속도를 증가시킨다. MCT 단백질 활성을 조정하는 물질은, 예를 들어 MCT 단백질 활성 또는 MCT 핵산의 발현을 자극한다. 상기 MCT 단백질 활성 또는 MCT 핵산의 발현을 자극하는 물질의 예로는 소분자, 활성 MCT 단백질 및 MCT 단백질을 코딩하는 핵산 등이 있으며, 이들을 세포에 도입한다. MCT 활성 또는 MCT 발현을 억제하는 물질의 예로는 소분자 및 안티센스 MCT 핵산 분자 등이 있다.
본 발명의 또다른 측면은 MCT 생형 유전자 또는 MCT-돌연변이 유전자를 세포에 도입하여 상기 유전자가 별개의 플라스미드에 유지되거나 숙주 세포의 게놈에 통합되도록 하는 단계를 포함하는, 세포로부터의 관심 화합물의 수율을 조정하는 방법에 관한 것이다. 게놈으로의 통합은 무작위로 발생하거나 상동성 재조합을 통해 발생하여, 천연 유전자가 세포에 의한 관심 화합물 생산이 조정되도록 하는 통합된 카피 (copy)로 대체되도록 할 수 있다. 바람직한 실시양태에서는 수율이 증가한다. 또다른 바람직한 실시양태에서, 상기 화학물질은 정밀 화학물질이고, 특히 바람직한 실시양태에서는 아미노산이다. 특히 바람직한 실시양태에서, 상기 아미노산은 L-리신이다.
본 발명은 코리네박테리움 글루타미쿰에서 세포막 성분의 대사 또는 이 막을 통한 화합물의 수송에 관여하는 MCT 핵산 및 MCT 단백질 분자를 제공한다. 본 발명의 분자는 코리네박테리움 글루타미쿰과 같은 미생물로부터 정밀 화학물질의 생산을 직접적으로 조절하는 데 사용할 수 있거나 (예를 들어, 지방산 생합성 단백질의 과다 발현 또는 최적화가 변형된 코리네박테리움 글루타미쿰으로부터 지방산의 수율, 생산, 및(또는) 생산 효율에 직접적으로 영향을 주는 경우), 또는 목적하는 화합물의 수율, 생산 및(또는) 생산 효율의 증가에 간접적으로 영향을 줄 수 있다 (예를 들어, 세포막 성분의 대사 조절은 수율, 생산 및(또는) 생산 효율, 또는 세포막의 조성을 변화시켜, 즉 1종 이상의 정밀 화학물질의 생산에 영향을 줄 수 있는 경우). 본 발명의 측면은 아래에 더 자세히 기재되어 있다.
I. 정밀 화학물질
용어 "정밀 화학물질"은 당업계에 공지되어 있고 유기체에 의해 생산되는 분자를 포함하며, 제약 산업, 농업 및 화장품 산업 등을 포함하나 이에 제한되지 않는 각종 분야의 산업에서 이용된다. 이러한 화합물로는 유기산, 예컨대 타르타르산, 이타콘산 및 디아미노피멜산, 단백질원성 및 비-단백질원성 아미노산, 퓨린 및 피리미딘 염기, 뉴클레오시드 및 뉴클레오티드 (예를 들어 문헌 [Kuninaka, A. (1996) Nucleotides and related compounds, pp. 561-612, in Biotechnology Vol. 6, Rehm et al., Editors VCH: Weinheim]과 그의 참고문헌에 기재된 바와 같음), 지질, 포화 및 불포화 지방산 (예컨대 아라키돈산), 디올 (예컨대 프로판디올 및 부탄디올), 탄수화물 (예컨대 하이알루론산 및 트레할로스), 방향족 화합물 (예컨대 방향족 아민, 바닐린 및 인디고), 비타민 및 보조인자 (문헌 ([Ullmann's Encyclopedia of Industrial Chemistry, Vol. A27, "Vitamins", pp. 443-613 (1996) VCH: Weinheim]과 그의 참고문헌 및 문헌 [Ong, A.S., Niki, E. and Packer, L. (1995) "Nutrition, Lipids, Health and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia and the Society for Free Radical Research - Asia, held Sept. 1-3, 1994, in Penang, Malaysia, AOCS Press (1995)]에 기재된 바와 같음), 문헌 [Gutcho (1983), Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086]및 상기 문헌에 인용된 참고문헌에 기재된 효소 및 모든 기타 화학물질 등이 있다. 특정 정밀 화학물질의 대사 및 용도는 하기에서 추가로 설명한다.
A. 아미노산의 대사 및 용도
아미노산은 모든 단백질의 기본적인 구조 단위를 포함하기 때문에, 모든 유기체에서의 정상적인 세포 기능에 필수적이다. 용어 "아미노산"은 당업계에 공지되어 있다. 단백질원성 아미노산에는 20종의 유형이 있으며 단백질의 구조 단위로서 작용하고 펩티드 결합에 의해 함께 연결되는 반면, 비-단백질원성 아미노산 (수백종이 공지되어 있음)은 통상적으로 단백질 내에 존재하지 않는다 (문헌 [Ullmann's Encyclopedia of Industrial Chemistry, Vol. A2, pp. 57-97 VCH: Weinheim (1985)] 참조). 아미노산은 광학적 D 또는 L 배위로 존재할 수 있지만, 천연 단백질에 존재하는 것은 통상적으로 L-아미노산 뿐이다. 20종의 단백질원성 아미노산 각각의 생합성 및 분해 경로는 원핵 세포 및 진핵 세포 둘다에 대하여 특징규명되어 있다 (예를 들어 문헌 [Stryer, L. Biochemistry, 3rdedition, pp. 578-590 (1988)] 참조). 생합성의 복잡성으로 인해 통상적으로 식품을 통해 섭취해야 하기 때문에 "필수 아미노산"이라 불리는 아미노산 (히스티딘, 이소루이신, 루이신, 리신, 메티오닌, 페닐알라닌, 트레오닌, 트립토판 및 발린)은 단순한 생합성 경로를 통해 다른 11종의 "비필수" 아미노산 (알라닌, 아르기닌, 아스파라긴, 아스파르테이트, 시스테인, 글루타메이트, 글루타민, 글리신, 프롤린, 세린 및 티로신)으로 전환된다. 고등 동물은 이러한 아미노산 중 일부를 합성할 수 있으나,통상의 단백질 합성이 일어나도록 하려면 필수 아미노산은 음식물로 섭취해야 한다.
이러한 아미노산은 단백질 생합성에서의 기능 이외에도 이와 같이 흥미로운 화학물질이며, 많은 아미노산들이 인간용 식료품, 동물 사료, 화학물질, 화장품, 농업 및 제약 산업에서 여러가지 용도를 갖는다는 것이 밝혀졌다. 리신은 인간 영양 뿐 아니라 가금류 및 돼지 등과 같은 단위 (monogastric) 가축에 있어서도 중요한 아미노산이다. 글루타메이트는 향미성 첨가제 (일나트륨 글루타메이트, MSG)로서 가장 흔히 사용되며, 그밖의 식품 산업에 사용되는 것은 아스파르테이트, 페닐알라닌, 글리신 및 시스테인이다. 글리신, L-메티오닌 및 트립토판은 모두가 제약 산업에 사용된다. 글루타민, 발린, 루이신, 이소루이신, 히스티딘, 아르기닌, 프롤린, 세린 및 알라닌은 제약 산업 및 화장품 산업에 사용된다. 트레오닌, 트립토판 및 D/L-메티오닌은 동물 사료 첨가제에 광범위하게 사용된다 [Leuchtenberger, W. (1996) Amino acids - technical production and use, pp. 466-502 in Rehm et al., (editors) Biotechnology Vol. 6, Chapter 14a, VCH: Weinheim]. 추가로, 이러한 아미노산은 합성 아미노산 및 단백질을 합성하기 위한 전구체, 예를 들어 N-아세틸시스테인, S-카르복시메틸-L-시스테인, (S)-5-히드록시트립토판 및 문헌 [Ullmann's Encyclopedia of Industrial Chemistry, Vol. A2, pp. 57-97, VCH, Weinheim, 1985]에 기재된 기타 물질로서 적합한 것으로 밝혀졌다.
박테리아 등과 같이 이러한 천연 아미노산을 생산할 수 있는 유기체에서의 이들의 생합성은 자세하게 특징규명되어 있다 (박테리아 아미노산 생합성 및 그의조절에 관해 검토하기 위해서는 문헌 [Umbarger, H.E. (1978) Ann. Rev. Biochem. 47:533-606] 참조). 글루타메이트는 시트르산 사이클의 중간체인 α-케토글루타레이트의 환원적 아미노화로 합성된다. 글루타민, 프롤린 및 아르기닌 각각은 글루타메이트로부터 연속적으로 생성된다. 세린의 생합성은 3-단계 과정으로 일어나며, 3-포스포글리세레이트 (해당작용의 중간체)로 출발하여 산화, 아미노 교환반응 및 가수분해 단계 이후에 세린이 된다. 시스테인 및 글리신 각각은 세린으로부터 생성되지만, 특이한 점은 시스테인은 호모시스테인과 세린의 축합으로 생성되고, 글리신은 세린 트랜스히드록시메틸라제에 의해 촉매되는 반응에서 측쇄 β-탄소 원자가 테트라히드로폴레이트에 전달되어 생성된다는 점이다. 페닐알라닌 및 티로신은 해당작용과 펜토스 포스페이트 경로의 전구체인 에리트로스 4-포스페이트와 포스포에놀피루베이트로부터 9-단계 생합성 경로를 거쳐 합성되는데, 이는 프레페네이트가 합성된 후의 마지막 2개 단계만이 다르다. 또한, 트립토판도 이러한 2종의 출발 분자로부터 생산되지만 11-단계 경로로 합성된다. 티로신 역시 페닐알라닌 히드록실라제가 촉매하는 반응을 통해 페닐알라닌으로부터 제조될 수 있다. 알라닌, 발린 및 루이신 각각은 해당작용의 최종 생성물인 피루베이트로부터 유도되는 생합성 생성물이다. 아스파르테이트는 시트레이트 사이클의 중간체인 옥살아세테이트로부터 형성된다. 아스파라긴, 메티오닌, 트레오닌 및 리신 각각은 아스파르테이트의 전환으로 생성된다. 이소루이신은 트레오닌으로부터 형성된다. 히스티딘은 활성화된 당인 5-포스포리보실 1-피로포스페이트로부터 복잡한 9-단계 경로로 형성된다.
단백질 생합성에서의 필요량을 초과하는 양의 아미노산은 저장될 수 없으며, 그 대신에 분해되어 세포의 주요 대사 경로에 중간체로서 제공된다 (검토하기 위해서는 문헌 [Stryer, L., Biochemistry, 3rdedition, Chapter 21 Amino Acid Degradation and the Urea Cycle"; pp. 495-516 (1988)] 참조). 세포가 원치않는 아미노산을 대사에 유용한 중간체로 전환시킬 수는 있지만, 아미노산 생산은 그의 합성에 필요한 에너지, 전구체 분자 및 효소를 고려할 때 고가이다. 따라서, 아미노산 생합성이 피드백 (feedback) 억제에 의해 조절되어 특정 아미노산의 존재가 그 아미노산 자체의 생산을 저하시키거나 완전하게 중단시킨다는 것은 놀라운 일이 아니다 (아미노산 생합성 경로의 피드백 기작에 대해 검토하기 위해서는 문헌 [Stryer, L., Biochemistry, 3rdedition, Chapter 24, "Biosynthesis of Amino acids and Heme", pp. 575-600 (1988)] 참조). 따라서, 특정 아미노산의 생산량은 세포 내에 존재하는 해당 아미노산의 양에 의해 제한된다.
B. 비타민, 보조인자 및 영양제 (nutraceutical)의 대사 및 용도
비타민, 보조인자 및 영양제는 또다른 군의 분자를 포함한다. 고등 동물은 이들에 대한 합성 능력이 없기 때문에 섭취해야만 하지만, 박테리아 등과 같은 다른 유기체는 이들을 쉽게 합성한다. 이들 분자는 그 자체가 생물활성 분자이거나 수많은 대사 경로에서 전자 캐리어 또는 중간체로 작용하는 생물활성 물질의 전구체이다. 이들 화합물에는 영양학적 가치 뿐 아니라 착색제, 항산화제 및 촉매 또는 기타 가공 보조제로서 유의한 산업적 가치도 있다 (이들 화합물의 구조, 활성및 산업적 용도를 검토하기 위해서는 예를 들어 문헌 [Ullmann's Encyclopedia of Industrial Chemistry, "Vitamins", Vol. A27, pp. 443-613, VCH: Weinheim, 1996] 참조). 용어 "비타민"은 당업계에 공지되어 있으며, 유기체의 정상적인 기능수행에는 필요하지만 이러한 유기체 자체로는 합성하지 못하는 영양소를 포함한다. 비타민군은 보조인자 및 영양제 화합물을 포함할 수 있다. 용어 "보조인자"는 정상적인 효소 활성을 나타내는데 필요한 비-단백질원성 화합물을 포함한다. 이들 화합물은 유기 또는 무기일 수 있다. 본 발명의 보조인자 분자는 유기인 것이 바람직하다. 용어 "영양제"는 식물 및 동물, 특히 인간의 건강을 증진시키는 식품 첨가제를 포함한다. 이러한 분자의 예로는 비타민, 항산화제 및 또한 특정 지질 (예컨대 다중불포화 지방산) 등이 있다.
박테리아 등과 같이 이러한 분자를 생산할 수 있는 유기체에서의 이들의 생합성은 포괄적으로 특징규명되어 있다 [Ullmann's Encyclopedia of Industrial Chemistry, "Vitamins", Vol. A27, pp. 443-613, VCH: Weinheim, 1996], [Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley ＆ Sons], [Ong, A.S., Niki, E. and Packer, L. (1995) "Nutrition, Lipids, Health and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia and the Society for free Radical Research - Asia, held on Sept. 1-3, 1994, in Penang, Malaysia, AOCS Press, Champaign, IL X, 374 S].
티아민 (비타민 B1)은 피리미딘 및 티아졸 단위의 화학적 커플링으로 형성된다. 리보플라빈 (비타민 B2)은 구아노신 5'-트리포스페이트 (GTP) 및 리보스 5'-포스페이트로부터 합성된다. 또한, 리보플라빈은 플라빈 모노뉴클레오티드 (FMN) 및 플라빈 아데닌 디뉴클레오티드 (FAD)의 합성에 이용된다. "비타민 B6"라고 통칭되는 군의 화합물들 (예컨대 피리독신, 피리독스아민, 피리독살 5'-포스페이트 및 시판되는 피리독신 히드로클로라이드)은 모두 공통적인 구조 단위인 5-히드록시-6-메틸피리딘의 유도체이다. 판토테네이트 (판토텐산, R-(+)-N-(2,4-디히드록시-3,3-디메틸-1-옥소부틸)-β-알라닌)은 화학적 합성 또는 발효를 통해 제조될 수 있다. 판토테네이트 생합성에서의 마지막 단계는 β-알라닌 및 판토산이 ATP-구동되어 축합되는 것으로 이루어진다. 판토산으로의 전환과 β-알라닌으로의 전환 및 판토텐산으로의 축합에 대한 생합성 단계를 담당하는 효소는 공지되어 있다. 판토테네이트의 대사 활성 형태는 5가지 효소 단계로 생합성되는 조효소 A이다. 판토테네이트, 피리독살 5'-포스페이트, 시스테인 및 ATP가 조효소 A의 전구체이다. 이러한 효소는 판토테네이트의 형성 뿐 아니라 (R)-판토산, (R)-판토락톤, (R)-판테놀 (프로비타민 B5), 판테테인 (및 그의 유도체) 및 조효소 A의 생산까지도 촉매한다.
미생물에서 전구체 분자인 피멜로일-CoA로부터 바이오틴이 생합성되는 과정은 상세하게 연구되어 왔으며, 이에 관여하는 여러개의 유전자가 확인되었다. 여러가지 상응하는 단백질들이 Fe 클러스터 합성에 관여하며 nifS 단백질 클래스에 속한다는 것이 밝혀졌다. 리폰산은 옥탄산에서 유도되어 에너지 대사의 조효소로작용하며 피루베이트 데히드로게나제 복합체 및 α-케토글루타레이트 데히드로게나제 복합체의 성분이다. 폴레이트는 L-글루탐산, p-아미노벤조산 및 6-메틸프테린으로부터 유도되는 엽산에서 유도되는 모든 물질들의 군이다. 구아노신 5'-트리포스페이트 (GTP), L-글루탐산 및 p-아미노벤조산의 생체내변환의 중간체로부터 출발하는 엽산 및 그의 유도체의 생합성은 특정 미생물에서 상세하게 연구되어 왔다.
코리노이드 (예컨대 코발라민 및 특히 비타민 B12) 및 포르피린은 테트라피롤 고리계로 구별되는 화학물질들의 군에 속한다. 비타민 B12의 생합성은 매우 복잡하여 완전하게 특징규명되지 못했으나, 이에 관여하는 많은 효소 및 기질이 현재 공지되어 있다. 니코틴산 (니코티네이트) 및 니코틴아미드는 "니아신"이라고도 지칭되는 피리딘 유도체이다. 니아신은 중요한 조효소인 NAD (니코틴아미드 아데닌 디뉴클레오티드) 및 NADP (니코틴아미드 아데닌 디뉴클레오티드 포스페이트) 및 이들의 환원 형태의 전구체이다.
리보플라빈, 비타민 B6, 판토테네이트 및 바이오틴 등과 같은 이들 화학물질 중 일부는 미생물의 대량 배양으로 생산되기도 하지만, 이들 화합물의 산업적 규모의 생산은 대부분이 무세포 화학적 합성을 기초로 한다. 오직 비타민 B12만이 그의 복잡한 합성법으로 인해 발효에 의해서만 생산된다. 시험관내 공정에는 상당한 재료 및 시간 소요가 요구되며, 종종 고비용이다.
C. 퓨린, 피리미딘, 뉴클레오시드 및 뉴클레오티드의 대사 및 용도
퓨린 및 피리미딘 대사 유전자 및 이들의 상응하는 단백질은 종양증 및 바이러스 감염의 치료에 중요한 표적이다. 용어 "퓨린" 또는 "피리미딘"은 핵산, 조효소 및 뉴클레오티드의 일부를 형성하는 질소-함유 염기를 포함한다. 용어 "뉴클레오티드"는 핵산 분자의 기본적인 구조 단위를 포괄하며, 질소-함유 염기, 펜토스 당 (RNA의 경우에는 상기 당이 리보스이고, DNA의 경우에는 상기 당이 D-데옥시리보스임) 및 인산을 포함한다. 용어 "뉴클레오시드"는 뉴클레오티드의 전구체로서 작용하는 분자를 포함하지만, 뉴클레오티드와는 달리 인산 단위는 보유하지 않는다. 이들 분자가 생합성되는 과정이나 이들이 동원되어 핵산 분자를 형성하는 과정을 억제함으로써 RNA 및 DNA 합성을 억제할 수 있으며, 암 세포에서 이러한 활성 억제를 표적으로 하면 종양 세포의 분열력 및 복제력을 억제할 수 있다. 또한, 핵산 분자를 형성하지 않고 에너지 저장물 (즉, AMP) 또는 조효소 (즉, FAD 및 NAD)로서 작용하는 뉴클레오티드도 존재한다.
이들 화학물질이 퓨린 및(또는) 피리미딘 대사에 영향을 줌으로써 이러한 의학적 조치에 사용될 수 있다는 것은 여러 간행물에 기재된 바 있다 (예를 들어 문헌 [Christopherson, R.I. and Lyons, S.D. (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents. "Med. Res. Reviews 10:505-548]). 퓨린 및 피리미딘 대사에 관여하는 효소에 대한 연구는 예를 들어 면역저해제 또는 항-증식제 등으로 이용할 수 있는 신약의 개발에 집중되어 왔다 ([Smith, J.L. "Enzymes in Nucleotide Synthesis" Curr. Opin. Struct. Biol. 5 (1995) 752-757], [Biochem. Soc. Transact. 23 (1995) 877-902]). 그러나, 퓨린 및 피리미딘 염기, 뉴클레오시드 및 뉴클레오티드는 각종 정밀 화학물질의 생합성에서 중간체 (예컨대 티아민, S-아데노실메티오닌, 폴레이트 또는 리보플라빈)로서의 용도, 세포의 에너지 캐리어 (예컨대 ATP 또는 GTP)로서의 용도 및 통상적으로 향미 증진제로서 사용되는 화학물질 자체 (예컨대 IMP 또는 GMP)로서의 용도 또는 많은 의학적 용도 (예를 들어 문헌 [Kuninaka, A., (1996) "Nucleotides and Related Compounds in Biotechnology" Vol. 6, Rehm et al., editors VCH: Weinheim, pp. 561-612] 참조)를 비롯한 다른 용도에도 가능하다. 퓨린, 피리미딘, 뉴클레오시드 또는 뉴클레오티드 대사에 관여하는 효소는 살진균제, 제초제 및 살곤충제를 비롯하여 작물 보호용으로 개발되고 있는 화학물질을 위한 표적으로 점점 더 크게 기능하고 있다.
박테리아에서 이들 화합물의 대사는 특징규명되어 있다 (검토하기 위해서는 예를 들어 문헌 [Zalkin, H. and Dixon, J.E. (1992) "De novo purine nucleotide biosynthesis" in Progress in Nucleic Acids Research and Molecular Biology, Vol. 42, Academic Press, pp. 259-287] 및 [Michal, G. (1999) Nucleotides and Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley, New York] 참조). 집중적인 연구 대상인 퓨린 대사는 세포의 정상적인 기능수행에 필수적이다. 고등 동물에서의 퓨린 대사 장애는 통풍 등과 같은 심각한 질병을 일으킬 수 있다. 퓨린 뉴클레오티드는 리보스 5'-포스페이트로부터 중간체 화합물인 이노신 5'-포스페이트 (IMP)를 거치는 수많은 단계를 통해 합성되어 구아노신 5'-모노포스페이트 (GMP) 또는 아데노신 5'-모노포스페이트 (AMP)를 생성하고, 이로부터 뉴클레오티드로서 사용되는 트리포스페이트형태가 쉽게 제조될 수 있다. 이들 화합물은 에너지 저장물로도 사용되어, 이들의 분해는 세포의 여러가지 상이한 생화학적 과정을 위한 에너지를 제공한다. 피리미딘 생합성은 리보스 5'-포스페이트로부터의 유리딘 5'-모노포스페이트 (UMP) 형성을 통해 일어난다. 또한, UMP는 시티딘 5'-트리포스페이트 (CTP)로 전환된다. 모든 뉴클레오티드의 데옥시 형태는 뉴클레오티드의 디포스페이트 리보스 형태로부터의 1-단계 환원 반응으로 제조되어 뉴클레오티드의 디포스페이트 데옥시리보스 형태를 생성한다. 이들 분자는 인산화 후에 DNA 합성에 이용될 수 있다.
D. 트레할로스 대사 및 용도
트레할로스는 α,α-1,1 연결기를 통해 함께 연결된 2개의 글루코스 분자로 구성된다. 이는 통상적으로 감미료, 건조 또는 동결 식품용 첨가제로서 식품 산업에 사용되고 음료 산업에 사용된다. 그러나, 이들은 제약 산업 또는 화장품 산업 및 생명공학 산업에서도 이용된다 (예를 들어, 니시모또 (Nishimoto) 등의 미국 특허 제5,759,610호 (1998), [Singer, M.A. and Lindquist, S. Trends Biotech. 16 (1998) 460-467], [Paiva, C.L.A. and Panek, A.D. Biotech Ann. Rev. 2 (1996) 293-314] 및 [Shiosaka, M. J. Japan 172 (1997) 97-102] 참조). 트레할로스는 많은 미생물의 효소에 의해 생산되어 주변 배지에 자연적으로 방출되며, 이로부터 트레할로스를 당업계에 공지된 방법으로 단리해 낼 수 있다.
II. 막 생합성 및 막횡단 수송
세포막은 세포에서 다양한 기능을 수행한다. 첫째, 세포막은 세포 함유물을 주변 환경으로부터 분리시키며, 따라서 세포에 일체성을 부여한다. 막은 또한 위험하거나 또는 원치 않는 화합물의 유입뿐 아니라 목적하는 화합물의 유출에 대한 장벽으로 작용할 수도 있다. 세포막은 본래, 극성 헤드 기가 외부를 향하고 있고 (각각 세포의 외부 및 내부를 향해) 비극성 테일이 이층의 중심으로 내부를 향하고 있어서 소수성 코어를 형성하는 그의 구조로 인해 단백질과 같은 소수성 화합물, 물 분자 및 이온의 비촉진성 확산에 대해 불투과성이다 (일반적으로, 막 구조 및 기능을 검토하기 위해서는, 문헌 (Gennis, R.B. (1989) Biomembranes, Molecular Structure and Function, Springer: Heidelberg)을 참조한다). 이 장벽은 세포가 주변 매질내에 포함되어 있는 것보다 목적하는 화합물은 더 높은 농도로 유지하고 원치 않는 화합물은 상대적으로 더 낮은 농도로 유지할 수 있게 만드는데, 이는 이들 화합물의 확산이 막에 의해 효과적으로 차단되기 때문이다.
그러나, 막은 또한 목적 화합물의 유입 및 폐 분자의 배출에 대한 효과적인 장벽으로도 존재한다. 이러한 곤란함을 극복하기 위해, 세포막은 막을 여러 종류의 화합물의 막횡단 수송을 촉진시킬 수 있는 많은 종류의 트랜스포터 단백질: 포어 또는 채널 및 트랜스포터를 포함하고 있다. 전자는 전체 막 단백질, 때로는 단백질 복합체로서, 막을 통하여 조절된 오리피스를 형성한다. 이러한 조절 또는 게이팅은 통상적으로 포어 또는 채널에 의해 수송될 분자에 대해 특이적이어서, 이 막횡단 구조물은 특정 종류의 기질에 대해 선택적으로 투과성이 되며, 예를 들어, 칼륨 채널은 칼륨과 유사한 전하 및 크기를 갖는 이온만이 통과할 수 있도록 구성된다. 채널 및 포어 단백질은, 이 단백질의 소수성 면이 막의 내부와 결합하는 반면, 친수성 면은 채널의 내부에 늘어서 있음으로 인해 선택된 친수성 분자가 통과할 수 있는 보호된 친수성 환경을 제공하도록, 분리된 소수성 및 친수성 도메인을 갖는 경향이 있다. 칼륨, 칼슘, 나트륨 및 클로라이드 이온에 대한 것을 비롯하여 이러한 많은 포어/채널이 당업계에 공지되어 있다.
촉진성 확산에 대한 상기의 포어 및 채널-매개 시스템은 이온과 같은 매우 작은 분자에 한정되는데, 이는 촉진성 확산에 의해 전체 단백질을 통과시키기에 충분한 크기의 포어 또는 채널이 더 작은 친수성 분자의 통과를 막을 수는 없기 때문이다. 이러한 과정에 의한 분자의 수송은 농도 구배의 동력이 필요하기 때문에 '촉진성 확산'이라고 때때로 표현한다. 퍼미아제는 또한, 글루코스 또는 기타 당의 농도가 세포의 한 측면에서 다른 측면보다 더 큰 경우, 세포내로 이들과 같은 더 큰 분자의 촉진성 확산 (또한 '유니포트 (uniport)'라고도 함)을 허용한다. 포어 또는 채널과는 대조적으로, 이러한 전체 막 단백질 (종종 막횡단 α-나선을 6 내지 14개 가짐)은 막을 통해 열린 채널을 형성하기보다는 막의 표면에서 표적 분자와 결합하고, 이어서 표적 분자가 막의 반대 측면으로 방출되도록 형태적 변화를 수행한다.
그러나, 세포는 흔히 촉진성 확산이 일어날 수 없는 상황에서 존재하는 농도 구배에 거슬러 분자의 유입 또는 유출 ('능동 수송')시켜야 할 필요가 있다. 이러한 막 수송에 대하여 세포에 의해 이용되는 두가지 일반적인 기작, 즉 심포트 또는 안티포트, 및 ABC 트랜스포터에 의해 매개되는 것과 같은 에너지-연계성 수송이 있다. 심포트 및 안티포트 시스템은 막을 가로질러 두가지 다른 분자의 이동을 연결시키는데 (두가지 다른 분자에 대한 두가지 별도의 결합 부위를 갖는 퍼미아제를통해); 심포트에서는, 두 분자가 같은 방향으로 수송되지만, 안티포트에서는 한 분자는 유입되고 다른 분자는 유출된다. 에너지면에서, 이러한 수송은 두 분자 중 하나가 농도 구배에 따라 이동하기 때문에 가능한 것이며, 에너지면에서 유리한 이 작용은 우세한 농도 구배에 거슬러 목적하는 화합물을 동시에 이동시키는 경우에만 허용된다. 개별적 분자들은 ABC 트랜스포터에 의해 이용되는 것과 같은 에너지-추진 과정에서 농도 구배에 거슬러 막을 통해 수송될 수 있다. 이 시스템에서, 막에 위치하는 수송 단백질은 ATP-결합 카세트를 갖는데, 표적 분자가 결합하게 되면, ATP는 ADP + Pi로 전환되고, 그로 인해 방출된 에너지가 이용됨으로써 트랜스포터에 의해 촉진되는 막의 반대 측면으로의 표적 분자의 이동을 추진시킨다. 이러한 수송 시스템 모두에 대한 보다 상세한 설명으로는 문헌[Bamberg, E. et al., (1993) "Charge transport of ion pumps on lipid bilayer membranes", Q. Rev. Biophys. 26: 1-25; Findlay, J.B.C. (1991) "Structure and function in membrane transport systems", Curr. Opin. Struct. Biol. 1: 804-810; Higgins, C.F. (1992) "ABC transporters from microorganisms to man", Ann. Rev. Cell Biol. 8: 67-113; Gennis, R.B. (1989) "Pores, Channels and Transporters", in: Biomembranes, Molecular Structure and Function, Springer: Heidelberg, pp. 270-322; 및 Nikaido, H. and Saier, H. (1992) "Transport proteins in bacteria: common themes in their design", Science 258: 936-942] 및 이들 문헌 각각에 포함된 참고 문헌을 참조한다.
막 합성은 다수의 성분이 관련된 잘 특징규명된 과정이며, 이들 성분 중 가장 중요한 것은 지질 분자이다. 지질 합성은 두 부분, 즉 지방산의 합성 및 지방산의 sn-글리세롤 3-포스페이트로의 부착, 및 극성 헤드 기의 부가 또는 변형으로 구분될 수 있다. 박테리아 막에서 이용되는 전형적인 지질로는 인지질, 당지질, 스핑고지질 및 포스포글리세리드가 포함된다. 지방산 합성은 아세틸-CoA가 각각 아세틸 CoA 카르복실라제에 의해 말로닐-CoA로, 아세틸트랜스아실라제에 의해 아세틸-ACP로 전환됨으로써 시작된다. 축합 반응에 이어서, 이들 두 생성물 분자는 함께 아세토아세틸-ACP를 형성하며, 이는 일련의 축합, 환원 및 탈수 반응에 의해 전환되어 목적하는 쇄 길이를 갖는 포화 지방산 분자를 생성한다. 이러한 분자로부터 불포화 지방산의 생성은 특정 불포화효소에 의해 산소 분자의 도움으로 호기적 또는 혐기적으로 촉진된다[지방산 합성에 대한 참고문헌으로는 문헌[F.C. Neidhardt et al. (1996) E. coli and Salmonella. ASM Press: Washington, D.C., pp. 612-636, 및 상기 문헌에 인용된 참고문헌; Lengeler et al. (editors) (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, 및 상기 문헌에 인용된 참고문헌; 및 Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542] 및 이들 문헌에 포함된 참고문헌을 참조한다]. 시클로프로판 지방산 (CFA)은 기질로서 SAM을 사용하여 특정 CFA 신타제에 의해 합성된다. 분지쇄 지방산은 탈아민하되어 분지쇄 2-옥소-산을 생성하는 분지쇄 아미노산으로부터 합성된다[문헌[Lengeler et al. (editors) (1999) Biology of Procaryotes. Thieme: Stuttgart, New York] 및 이 문헌에 포함된 참고문헌을 참조한다]. 지질 합성에서 다른 필수적인 단계는, 예를 들어, 글리세롤-포스페이트-아실트랜스퍼라제에 의한 극성 헤드 기 상으로의 지방산의 전이이다. 다양한 전구체 분자 및 생합성 효소를 병용하여 막의 조성에 큰 영향을 미치는 여러 지방산 분자를 생성한다.
III. 본 발명의 요소 및 방법
본 발명은, 부분적으로는, 코리네박테리움 글루타미쿰에서 세포막 형성을 조절하며 이 막을 통한 분자의 이동을 조절하는, 본원에서 MCT 핵산 및 MCT-단백질 분자로 언급되는 새로운 분자의 발견을 기초로 한다. 한 실시양태에서, MCT 분자는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 및 이 막을 통한 분자의 수송에 관여한다. 바람직한 실시양태에서, 막 성분의 생산 및 막 수송을 조절하는 본 발명의 MCT 분자의 활성은 이 생물에 의한 목적하는 정밀 화학물질의 생산에 영향을 준다. 특히 바람직한 실시양태에서, 본 발명의 MCT 단백질이 조절하는 코리네박테리움 글루타미쿰 대사 경로가 수율, 생산 및(또는) 생산 효율면에서 조절되고, 막을 통한 화합물의 수송 효율이 변경되어, 코리네박테리움 글루타미쿰에 의해 목적하는 정밀 화학물질 생산의 수율, 생산 및(또는) 생산 효율이 직접적 또는 간접적으로 조절되도록 본 발명의 MCT 분자의 활성을 조절한다.
용어 "MCT 단백질" 또는 "MCT 폴리펩티드"에는 코리네박테리움 글루타미쿰 세포막의 구성에 필요한 화합물의 대사, 또는 이 막을 통한 분자의 수송에 관여하는 단백질이 포함된다. MCT 단백질의 예에는 표 1 및 첨부문서 A에 기재된 MCT 유전자에 의해 코딩되는 것들이 포함된다. 용어 "MCT 유전자" 또는 "MCT 핵산 서열"에는 코딩 영역 및 이에 대응하는 번역되지 않는 5' 및 3' 서열 영역으로 이루어진, MCT 단백질을 코딩하는 핵산 서열이 포함된다. MCT 유전자의 예로는 표 1에 기재된 것들이 포함된다. 용어 "생산" 또는 "생산성"은 당업계에 공지된 용어이며, 소정의 시간 및 소정의 발효 용적내에서 형성되는 발효 생성물의 농도 (예를 들어, 1시간에 1리터 당 kg 생성물)가 포함된다. 용어 "생산 효율"에는 특정 생성물 농도를 달성하는데 요구되는 시간 (예를 들어, 세포가 특정 비율의 정밀 화학물질 생성물을 얻는데 걸리는 시간)이 포함된다. 용어 "수율" 또는 "생성물/탄소 수율"은 당업계에 공지된 용어이며, 탄소 공급원의 생성물 (즉, 정밀 화학물질)로의 전환 효율이 포함된다. 이 용어는 일반적으로는, 예를 들어, 탄소 공급원 kg 당 생성물 kg으로 표기된다. 화합물의 수율 또는 생산율을 증대시킴으로써, 소정의 시간 동안 얻어지는 수득량의 배양물 중 이 화합물의 회수된 분자의 양 또는 유용한 분자의 양은 증가하게 된다. 용어 "생합성" 또는 "생합성 경로"는 당업계에 공지된 용어이고, 세포에 의한 중간체 화합물로부터의 화합물, 바람직하게는 유기 화합물의 합성을 포함하며, 다단계의 고도로 조절되는 과정일 수 있다. 용어 "분해" 또는 "분해 경로"는 당업계에 공지된 용어이고, 세포에 의한 화합물, 바람직하게는 유기 화합물의 분해 생성물 (일반적으로 말해서, 더 작거나 덜 복잡한 구조의 분자)로의 분해를 포함하며, 다단계의 고도로 조절되는 과정일 수 있다. 용어 "대사"는 당업계에 공지된 용어이고, 유기체에서 발생하는 생화학 반응 전체가 포함된다. 이어서, 특정 화합물의 대사 (예를 들어, 글리신 등의 아미노산의 대사)에는 이러한 화합물과 관련되는 세포의 전체 생합성, 변형, 및 분해 경로가 포함된다.
또다른 실시양태에서, 본 발명의 MCT 분자는 코리네박테리움 글루타미쿰과 같은 미생물에서 정밀 화학물질 등의 목적하는 분자의 생산을 조절할 수 있다. 본 발명의 MCT 분자의 변형이 변형된 단백질을 혼입하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질 생산의 수율, 생산율 및(또는) 생산 효율에 직접 영향을 줄 수 있는 다수의 기작이 있다. 세포로부터의 정밀 화학물질 분자의 배출에 관여하는 이러한 MCT 단백질을, 이러한 화합물이 보다 쉽게 회수되는 세포외 매질로 더 많은 양이 분비되도록, 그의 수 또는 활성을 증가시킬 수 있다. 마찬가지로, 1종 이상의 정밀 화학물질 (예를 들어, 포스페이트, 술페이트 질소 화합물 등)의 생합성에 필요한 영양분의 유입에 관여하는 MCT 단백질을, 이러한 전구체, 보조인자 또는 중간체 화합물의 세포내 농도가 증가되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 지방산 및 지질 자체는 바람직한 정밀 화학물질이며, 이러한 화합물의 생합성에 관여하는 1종 이상의 본 발명의 MCT 단백질의 활성을 최적화하거나 또는 그의 수를 증가시킴으로써, 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 손상시킴으로써, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
본 발명의 1종 이상의 MCT 유전자의 돌연변이유발에 의해 코리네박테리움 글루타미쿰으로부터 1종 이상의 목적하는 정밀 화학물질의 생산에 직접적으로 영향을 주는, 변화된 활성을 갖는 MCT 단백질을 생성시킬 수도 있다. 예를 들어, 폐 생성물의 배출에 관여하는 본 발명의 MCT 단백질을, 세포의 정상적인 대사성 폐기물 (목적하는 정밀 화학물질의 과다생산으로 인해 양이 증가될 수 있음)이 세포내에서뉴클레오티드 및 단백질을 손상시키거나 (세포의 생존율이 감소됨) 또는 정밀 화학물질 생합성 경로를 방해하기 (목적하는 정밀 화학물질의 수율, 생산 또는 생산 효율이 저하됨) 전에 효과적으로 배출되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 세포내에서 비교적 다량인 정밀 화학물질은 그 자체로도 세포에 독성을 띨 수 있어서, 세포로부터 이 화합물을 배출시킬 수 있는 트랜스포터의 활성 또는 수를 증가시킴으로써, 배양물내 세포의 생존율을 증가시킬 수 있고, 또한 배양물내에서 목적하는 정밀 화학물질을 생산하는 세포수를 더 증가시킬 수 있다. 상대적 양의 다른 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을 조작할 수도 있다. 이는 세포막의 지질 조성에 상당한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가지기 때문에, 막의 지질 조성에 있어서의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성에서의 변화는 막을 통한 분자의 수송성뿐 아니라 세포의 일체성에 영향을 줄 수 있으며, 이들 둘 다는 대규모 발효 배양에서 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 생산에 상당한 영항을 준다.
본 발명의 핵산 서열을 제조하는데 적합한 출발점은 아메리칸 타입 컬쳐 콜렉션 (American Type Culture Collection)에서 ATCC 13032로 입수할 수 있는 코리네박테리움 글루타미쿰 균주의 게놈이다.
본 발명의 핵산 서열은 통상의 방법을 이용하여 표 1에 나타낸 변형을 통해 상기 핵산 서열로부터 제조할 수 있다.
본 발명의 MCT 단백질 또는 그의 생물학적으로 활성인 절편 또는 단편은 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을통한 분자의 수송에 관여하거나 또는 표 1에 기재된 활성을 한가지 이상 가질 수 있다.
하기 단락에서는 본 발명의 여러가지 측면을 더욱 상세하게 기재한다:
A. 단리된 핵산 분자
본 발명의 한 측면은 MCT 폴리펩티드 또는 그의 생물학적으로 활성인 일부를 코딩하는 단리된 핵산 분자뿐 아니라 MCT-코딩 핵산 (예를 들어, MCT DNA) 확인 또는 증폭을 위한 혼성화 프로브 또는 프라이머로 사용하기에 충분한 핵산 단편에 관한 것이다. 용어 "핵산 분자"는 DNA 분자 (예를 들어, cDNA 또는 게놈 DNA), RNA 분자 (예를 들어, mRNA), 및 뉴클레오티드 유사체를 사용하여 생성되는 DNA 또는 RNA 유사체를 포함하는 의미이다. 이 용어에는 또한 유전자의 코딩 영역의 3' 및 5' 말단의 둘 다에 위치하는 비번역 서열, 코딩 영역의 5' 말단으로부터 상류의 약 100개 이상의 뉴클레오티드 서열, 및 이 유전자의 코딩 영역의 3' 말단으로부터 하류의 약 20개 이상의 뉴클레오티드 서열이 포함된다. 핵산 분자는 단일 가닥 또는 이중 가닥일 수 있으며, 바람직하게는 이중 가닥 DNA이다. "단리된" 핵산 분자는 핵산의 천연 공급원에 존재하는 다른 핵산 분자로부터 분리되는 것이다. 바람직하게는, "단리된" 핵산은 이 핵산이 유도되는 생물의 게놈 DNA에서 본래 핵산를 플랭킹하는 서열 (즉, 핵산의 5' 및 3' 말단에 위치하는 서열)을 가지고 있지 않다. 예를 들어, 다양한 실시양태에서, 단리된 MCT 핵산 분자는 이 핵산이 유도되는 세포 (예를 들어, 코리네박테리움 글루타미쿰 세포)의 게놈 DNA에서 본래 핵산 분자를 플랭킹하는 약 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb 또는 0.1 kb 보다 작은크기의 뉴클레오티드 서열을 포함할 수 있다. 게다가, "단리된" 핵산 분자, 예를 들어, DNA 분자는, 재조합 기술에 의해 생산되는 경우 다른 세포 물질 또는 배양 배지, 또는 화학적으로 합성되는 경우 화학물질 전구체 또는 다른 화학물질을 실제적으로 함유하지 않는다.
표준 분자 생물학 기술 및 본원에 제공되는 서열 정보를 이용하여, 본 발명의 핵산 분자, 예를 들어, 첨부문서 A의 뉴클레오티드 서열을 갖는 핵산 분자 또는 그의 절편을 단리할 수 있다. 예를 들어, 첨부문서 A로부터의 전체 서열 또는 그의 절편을 혼성화 프로브로 사용하고 표준 혼성화 기술 (예를 들어, 문헌[Sambrook, J., Fritsh, E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]에 기재됨)을 사용하여 코리네박테리움 글루타미쿰 라이브러리로부터 코리네박테리움 글루타미쿰 MCT cDNA를 단리할 수 있다. 더우기, 상기 서열을 기초로 하여 제조된 올리고뉴클레오티드 프라이머를 사용하여 중합효소 연쇄반응에 의해 첨부문서 A로부터의 전체 서열 또는 그의 절편을 포함하는 핵산 분자를 단리할 수 있다 (예를 들어, 첨부문서 A와 동일한 서열을 기초로 하여 제조된 올리고뉴클레오티드 프라이머를 사용하여 중합효소 연쇄반응에 의해 첨부문서 A로부터의 전체 서열 또는 그의 절편을 포함하는 핵산 분자를 단리할 수 있음). 예를 들어, mRNA는 정상 내피 세포로부터 (예를 들어, 문헌[Chirgwin et al.(1979) Biochemistry 18:5294-5299]의 구아니디늄-티오시아네이트 추출 방법에 의해) 단리할 수 있고, cDNA는 역전사효소 (예를 들어, Gibco/BRL(Bethesda, MD)로부터 입수가능한 몰로니-MLV 역전사효소; 또는 세이까가꾸 아메리카, 인크. (Seikagaku America, Inc., St. Petersburg, FL)로부터 입수가능한 AMV 역전사효소)를 사용하여 제조할 수 있다. 첨부문서 A에 기재된 뉴클레오티드 서열 중 하나를 기초로 하여 중합효소 연쇄반응에 의한 증폭용 합성 올리고뉴클레오티드 프라이머를 설계할 수 있다. 본 발명의 핵산은 cDNA 또는, 별법으로, 게놈 DNA를 주형으로 사용하고 표준 PCR 증폭 기술에 따라 적절한 올리고뉴클레오티드 프라이머를 사용하여 증폭시킬 수 있다. 이와 같이 증폭된 핵산을 적절한 벡터내에 클로닝하고 DNA 서열 분석에 의해 특성화할 수 있다. 또한, MCT 뉴클레오티드 서열에 상응하는 올리고뉴클레오티드는 표준 합성 기술, 예를 들어, 자동 DNA 합성기를 사용하여 제조할 수 있다.
바람직한 실시양태에서, 본 발명의 단리된 핵산 분자는 첨부문서 A에 기재된 뉴클레오티드 서열 중 하나를 포함한다.
추가의 바람직한 실시양태에서, 본 발명의 단리된 핵산 분자는 첨부문서 A에 나타낸 뉴클레오티드 서열 중 어느 하나와 상보적인 핵산 분자 또는 그의 절편을 포함하며, 상기 핵산 분자는 첨부문서 A에 나타낸 뉴클레오티드 서열 중 어느 하나에 대해 충분히 상보적이어서, 첨부문서 A에 나타낸 서열 중 어느 하나와 혼성화하여 안정한 이중쇄를 형성한다.
한 실시양태에서, 본 발명의 핵산 분자는 코리네박테리움 글루타미쿰에서 세포막을 구성하는데 필요한 화합물의 대사에서 또는 상기 막을 가로질러 분자를 수송하는데 작용할 수 있는, 단백질에 대한 첨부문서 B의 아미노산 서열에 충분한 상동성이 있는 아미노산 서열 또는 그의 절편을 포함하는 단백질 또는 그의 절편을 코딩한다. 본원에서 사용된 바와 같이, 용어 "충분한 상동성이 있는"은 단백질 또는 그의 절편이 코리네박테리움 글루타미쿰에서 세포막을 구성하는데 필요한 화합물의 대사에서 또는 상기 막을 가로질러 분자를 수송하는데 작용할 수 있도록, 아미노산 서열이 첨부문서 B의 아미노산 서열과 동일한 아미노산 잔기 또는 그와 동등한 아미노산 잔기 (예를 들어 첨부문서 B에 나타낸 임의의 서열의 아미노산 잔기의 측쇄와 유사한 측쇄를 갖는 아미노산 잔기)를 최소수로 보유하는 단백질 또는 그의 절편과 관련된 것이다. 본원에 기재된 막 성분 또는 막 수송 시스템에 대한 이들 대사 경로의 단백질 성분은 1종 이상의 정밀 화학물질의 생산 및 분비에 작용할 수 있다. 이러한 활성의 예는 또는 본원에 기재되어 있다. 따라서, "MCT 단백질의 기능"은 1종 이상의 정밀 화학물질의 대사 경로에 대한 전반적 조절 또는 탄화수소의 분해 또는 테르페노이드의 산화에 기여한다. 표 1은 MCT 단백질 활성의 예를 기재한다.
본 발명의 MCT 핵산 분자가 코딩하는 단백질의 절편은 임의의 MCT 단백질의 생물학적 활성 절편인 것이 바람직하다. 본원에서 사용된 바와 같이, 용어 "MCT 단백질의 생물학적 활성 절편"은 코리네박테리움 글루타미쿰에서 세포막을 구성하는데 필요한 화합물의 대사에서 또는 상기 막을 가로질러 분자를 수송하는데 관여할 수 있거나 표 1에 기재된 활성을 보유하는 MCT 단백질의 절편, 예를 들어 도메인 또는 모티프를 포함하고자 한다. MCT 단백질 또는 그의 생물학적 활성 절편이 코리네박테리움 글루타미쿰에서 세포막을 구성하는데 필요한 화합물의 대사에서 또는 상기 막을 가로질러 분자를 수송하는데 관여할 수 있는 지의 여부는 효소 활성 분석을 수행하여 결정할 수 있다. 이러한 분석 방법은 실시예 단락의 실시예 8에 상세하게 기재한 바와 같이 당업자에게 공지되어 있다.
당업자는 집단 내에 존재할 수 있는 천연 MCT-서열 변이체 뿐 아니라 첨부문서 A의 뉴클레오티드 서열에 돌연변이에 의한 변화가 도입되어, 코딩된 MCT 단백질의 아미노산 서열을 변화시키면서도 MCT 단백질의 기능을 손상시키지 않을 수 있음을 이해할 것이다. 예를 들어, 첨부문서 A의 서열에서 "비필수" 아미노산 잔기에서의 아미노산 치환을 일으키는 뉴클레오티드 치환을 생성할 수 있다. "비필수" 아미노산 잔기는 임의의 MCT 단백질의 야생형 서열 (첨부문서 B)을 변경시키면서도 상기 MCT 단백질의 활성을 변화시키지 않을 수 있는 잔기이며, "필수" 아미노산 잔기는 MCT 단백질 활성에 필요한 잔기이다. 그러나, 다른 아미노산 잔기 (예컨대 MCT 활성을 갖는 도메인에서 비-보존 또는 단지 반-보존된 아미노산 잔기)가 활성에 비필수일 수도 있기 때문에 이를 변형시키면서 MCT 활성은 변형시키지 않을 수도 있을 것이다.
첨부문서 B의 단백질 서열에 상동성이 있는 MCT 단백질을 코딩하는 단리된 핵산 분자는 첨부문서 A의 뉴클레오티드 서열에 하나 이상의 뉴클레오티드 치환, 부가 또는 결실을 도입하여 생성할 수 있으며, 이에 의해 코딩된 단백질에는 하나 이상의 아미노산 치환, 부가 또는 결실이 도입된다. 상기 돌연변이는 부위-지정 돌연변이유발법 및 PCR-매개 돌연변이유발법 등과 같은 표준 기술을 통해 첨부문서 A에 나타낸 임의의 서열에 도입될 수 있다. 하나 이상의 추정 비필수 아미노산 잔기에 보존적 아미노산 치환을 도입하는 것이 바람직하다. "보존적 아미노산 치환"은 해당 아미노산 잔기를 유사한 측쇄를 갖는 아미노산 잔기로 치환한다. 유사한 측쇄를 갖는 아미노산 잔기의 군은 당업계에 규정되어 있다. 이들 군은 염기성 측쇄를 갖는 아미노산 (예컨대 리신, 아르기닌, 히스티딘), 산성 측쇄를 갖는 아미노산 (예컨대 아스파르트산, 글루탐산), 비하전 극성 측쇄를 갖는 아미노산 (예컨대 글리신, 아스파라긴, 글루타민, 세린, 트레오닌, 티로신, 시스테인), 비극성 측쇄를 갖는 아미노산 (예컨대 알라닌, 발린, 루이신, 이소루이신, 프롤린, 페닐알라닌, 메티오닌, 트립토판), 베타-분지된 측쇄를 갖는 아미노산 (예컨대 트레오닌, 발린, 이소루이신) 및 방향족 측쇄를 갖는 아미노산 (예컨대 티로신, 페닐알라닌, 트립토판, 히스티딘)을 포함한다. 따라서, MCT 단백질에서 추정된 비필수 아미노산 잔기는 동일 측쇄군의 또다른 아미노산 잔기로 치환되는 것이 바람직하다. 별법으로, 또다른 실시양태에서는 상기 돌연변이를 MCT-코딩 서열 전체 또는 일부에 예를 들어 포화 돌연변이유발법 등을 통해 무작위로 도입할 수 있고, 생성되는 돌연변이체를 본원에 기재한 MCT 활성에 대해 시험하여 MCT 활성을 유지하는 돌연변이체를 확인할 수 있다. 첨부문서 A에 나타낸 임의의 서열을 돌연변이유발시킨 후에, 코딩되는 단백질을 재조합으로 발현시킬 수 있고, 상기 단백질의 활성을 예를 들어 본원에 기재한 분석법을 이용하여 측정할 수 있다 (실시예 단락의 실시예 8 참조).
B. 재조합 발현 벡터 및 숙주 세포
본 발명의 또다른 측면은 MCT 단백질 (또는 그의 절편)을 코딩하는 핵산을함유하는 벡터, 바람직하게는 발현 벡터에 관한 것이다. 본원에서 사용된 바와 같이, 용어 "벡터"는 그와 결합된 또다른 핵산을 수송할 수 있는 핵산 분자와 관련된 것이다. 벡터의 유형 중 하나는 추가의 DNA 세그먼트가 라이게이션될 수 있는 원형 이중 가닥 DNA 루프를 의미하는 용어인 "플라스미드"이다. 또다른 유형의 벡터는 바이러스 벡터이며, 여기서는 추가의 DNA 세그먼트를 바이러스 게놈에 라이게이션시킬 수 있다. 몇몇 벡터들은 그들이 도입된 숙주 세포 내에서 자율적으로 복제될 수 있다 (예를 들어, 박테리아 복제 기점을 갖는 박테리아 벡터 및 에피솜 포유동물 벡터). 다른 벡터들 (예컨대 비-에피솜 포유동물 벡터)은 숙주 세포에 도입될 때 상기 숙주 세포의 게놈에 통합됨으로써 숙주 게놈과 함게 복제된다. 추가로, 몇몇 벡터들은 기능적으로 연결된 유전자의 발현을 제어할 수 있다. 본원에서는 이러한 벡터를 "발현 벡터"라고 지칭한다. 통상, DNA 재조합 기술에 사용되는 발현 벡터는 플라스미드 형태이다. 플라스미드가 가장 일반적으로 사용되는 유형의 벡터이므로, 본 명세서에서는 "플라스미드" 및 "벡터"를 혼용한다. 그러나, 본 발명은 유사한 기능을 발휘하는 다른 유형의 발현 벡터, 예를 들어 바이러스 벡터 (예컨대 복제-결핍 레트로바이러스, 아데노바이러스 및 아데노바이러스-관련 바이러스)를 포함한다.
본 발명의 재조합 발현 벡터는 본 발명의 핵산을 숙주 세포에서의 발현에 적합한 형태로 포함하며, 이는 재조합 발현 벡터가 발현에 사용될 숙주 세포를 기초로 하여 선택되고 발현될 핵산 서열에 기능적으로 연결된 하나 이상의 조절 서열을 포함함을 의미한다. 재조합 발현 벡터에서, 용어 "기능적으로 연결된"은 관심 뉴클레오티드 서열이 그의 발현 (예를 들어 시험관내 전사/번역 시스템에서 발현되거나 또는 상기 벡터가 숙주 세포에 도입된 경우에는 그 숙주 세포에서 발현됨)이 가능하도록 조절 서열(들)에 결합된 것을 의미한다. 용어 "조절 서열"은 프로모터, 레프레서-결합 부위, 활성자-결합 부위, 인핸서 영역 및 다른 발현 제어 요소 (예컨대 종결자, mRNA 2차 구조의 다른 요소 또는 폴리아데닐화 신호)를 포함한다. 이러한 조절 서열에 대해서는 예를 들어 문헌 [Goeddel: Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990)] 등에 기재되어 있다. 조절 서열은 여러 유형의 숙주 세포에서 뉴클레오티드 서열의 구성적 발현을 제어하는 서열 및 특정 숙주 세포에서만 뉴클레오티드 서열의 발현을 제어하는 서열을 포함한다. 당업자라면, 발현 벡터의 고안이 형질전환시킬 숙주 세포의 선택, 원하는 단백질 발현 정도 등과 같은 인자에 따라 달라질 수 있음을 이해할 것이다. 본 발명의 발현 벡터를 숙주 세포에 도입함으로써, 본원에 기재한 바와 같은 핵산에 의해 코딩되는 융합 단백질 또는 융합 펩티드 (예컨대 MCT 단백질, MCT 단백질의 돌연변이된 형태, 융합 단백질 등)를 비롯한 단백질 또는 펩티드를 제조할 수 있다.
본 발명의 재조합 발현 벡터는 원핵 세포 또는 진핵 세포에서 MCT 단백질을 발현하도록 고안될 수 있다. 예를 들면, MCT 유전자는 박테리아 세포, 예를 들어 코리네박테리움 글루타미쿰, 곤충 세포 (이 경우에는 바큘로바이러스 발현 벡터를 사용함), 효모 세포 및 기타 진균 세포 (문헌 [Romanos, M.A. et al. (1992) "Foreign gene expression in yeast: a review" Yeast 8: 423-488], [van denHondel, C.A.M.J.J. et al. (1991) "Heterologous gene expression in filamentous fungi" in: More Gene Manipulations in Fungi, J.W. Bennet ＆ L.L. Lasure, Editors, pp. 396-428: Academic Press: San Diego] 및 [van den Hondel, C.A.M.J.J. ＆ Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi" in: Applied Molecular Genetics of Fungi, Peberdy, J.F. et al., Editors, pp. 1-28, Cambridge University Press: Cambridge] 참조), 조류 및 다세포 식물 세포 (문헌 [Schmidt, R. and Willmitzer, L. (1988) "High efficiency Agrobacterium tumefaciens-mediated transformation of Arabidopsis thaliana leaf and cotyledon explants", Plant Cell Rep.: 583-586] 참조) 또는 포유동물 세포에서 발현될 수 있다. 적합한 숙주 세포는 문헌 [Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990)]에 추가로 논의되어 있다. 별법으로, 재조합 발현 벡터는 예를 들어 T7 프로모터 조절 서열 및 T7 폴리머라제를 사용하여 시험관내 전사 및 번역시킬 수 있다.
단백질은 융합 또는 비-융합 단백질의 발현을 제어하는 구성적 또는 유도가능한 프로모터를 함유하는 벡터를 주로 사용하여 원핵생물에서 발현시킨다. 융합 벡터는 그에 의해 코딩되는 단백질에, 통상적으로는 재조합 단백질의 아미노 말단에 수많은 아미노산을 부가한다. 이러한 융합 벡터는 통상적으로 다음의 3가지 기능을 수행한다: 1) 재조합 단백질의 발현을 증진시킴; 2) 재조합 단백질의 가용성을 증가시킴; 3) 친화성 정제시에 리간드로서 작용하여 재조합 단백질의 정제를 보조함. 종종, 융합 발현 벡터에서 융합 단위와 재조합 단백질의 접합부에 단백질분해성 절단 부위를 도입함으로써, 재조합 단백질이 융합 단백질의 정제 후에 상기 융합 단위로부터 분리될 수 있도록 한다. 이러한 효소 및 이들의 상응하는 인식 서열은 인자 Xa, 트롬빈 및 엔테로키나제를 포함한다.
통상의 융합 발현 벡터는 재조합 표적 단백질에 글루타티온 S-트랜스퍼라제 (GST)가 융합된 pGEX (파마시아 바이오테크 인크. (Pharmacia Biotech Inc.) 제품, [Smith, D.B. and Johnson, K.S. (1988) Gene 67:31-40]), 재조합 표적 단백질에 말토스 E-결합 단백질이 융합된 pMAL (미국 매사추세츠주 배벌리에 소재하는 뉴 잉글랜드 바이오랩스 (New England Biolabs) 제품) 및 재조합 표적 단백질에 단백질 A가 융합된 pRIT 5 (미국 뉴저지주 피스카타웨이에 소재하는 파마시아 제품)를 포함한다. 한 실시양태에서, MCT 단백질-코딩 서열을 pGEX 발현 벡터에 클로닝하여, 상기 벡터가 N-말단에서 C-말단 방향으로 GST-트롬빈 절단 부위-단백질 X를 포함하는 융합 단백질을 코딩하도록 한다. 융합 단백질은 글루타티온-아가로스 수지를 사용한 친화성 크로마토그래피로 정제할 수 있다. GST에 융합되지 않은 재조합 MCT 단백질은 융합 단백질을 트롬빈으로 절단하여 수득할 수 있다.
적합한 유도가능한 비-융합 대장균 발현 벡터의 예로는 pTrc [Amann et al., (1988) Gene 69:301-315] 및 pET 11d [Studier et al. Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89] 등이 있다. pTrc 벡터로부터의 표적-유전자 발현은 숙주 RNA 폴리머라제에 의한 하이브리드 trp-lac 융합 프로모터로부터의 전사를 기초로 한다.pET 11d 벡터로부터의 표적-유전자 발현은 동시발현되는 바이러스 RNA 폴리머라제 (T7 gn1)에 의해 매개되는 T7-gn10-lac 융합 프로모터로부터의 전사를 기초로 한다. BL 21 (DE3) 또는 HMS174 (DE3) 숙주 균주에서, 상기 바이러스 폴리머라제는 lacUV 5 프로모터의 전사 제어를 받는 T7 gn1 유전자를 보유하는 상재성 λ 프로파지에 의해 제공된다.
재조합 단백질의 발현을 최대화하기 위한 전략 중 하나는 상기 재조합 단백질을 그에 대한 단백질분해성 절단력이 파괴된 숙주 박테리아에서 발현시키는 것이다 [Gottesman, S. Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128]. 또다른 전략은 발현 벡터로 삽입될 핵산의 핵산 서열을 변형시켜 각 아미노산에 대한 개개의 코돈이 발현을 위해 선택한 박테리아, 예를 들어 코리네박테리움 글루타미쿰에서 바람직하게 이용되는 코돈이 되도록 하는 것이다 [Wada et al. (1992) Nucleic Acids Res. 20:2111-2118]. 본 발명의 핵산 서열에 대한 이러한 변형은 DNA 합성의 표준 기술을 이용하여 수행할 수 있다.
추가의 실시양태에서, MCT 단백질 발현 벡터는 효모 발현 벡터이다. 효모 사카로마이세스 세레비지애 (Saccharomyces cerevisiae)에서 발현시키기 위한 벡터의 예로는 pYepSec1 [Baldari et al., (1987) Embo J. 6:229-234], pMFa [Kurjan and Herskowitz (1982) Cell 30:933-943], pJRY88 [Schultz et al. (1987) Gene 54:113-123] 및 pYES2 (미국 캘리포니아주 샌 디에고에 소재하는 인비트로젠 코포레이션 (Invitrogen Corporation) 제품) 등이 있다. 다른 진균, 예를 들어 섬유상진균에 사용하기에 적합한 벡터 및 그의 제작 방법은 문헌 [van den Hondel, C.A.M.J.J. ＆ Punt, P.J. (1991) "Gene Transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J.F. Peberdy et al., Editors, pp. 1-28, Cambridge University Press: Cambridge]에 상세하게 기재된 것들을 포함한다.
별법으로, 본 발명의 MCT 단백질은 바큘로바이러스 발현 벡터를 사용한 곤충 세포에서 발현될 수도 있다. 배양된 곤충 세포 (예컨대 Sf9 세포)에서의 단백질 발현에 이용가능한 바큘로바이러스 벡터로는 pAc 계열 [Smith et al., (1983) Mol. Cell Biol. 3:2156-2165] 및 pVL 계열 [Lucklow and Summers (1989) Virology 170:31-39] 등이 있다.
추가의 실시양태에서, 본 발명의 MCT 단백질은 단세포 식물 세포 (예컨대 조류) 또는 고등 식물 (예컨대 작물 등의 종자식물) 세포에서 발현될 수 있다. 식물 발현 벡터의 예로는 문헌 ([Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border", Plant Mol. Biol. 20:1195-1197] 및 [Bevan, M.W. (1984) "Binary Agrobacterium vectors for plant transformation", Nucl. Acids Res. 12:8711-8721])에 상세하게 기재된 것들을 포함한다.
추가의 실시양태에서, 본 발명의 핵산 발현을 포유동물 발현 벡터를 사용한 포유동물 세포에서 수행한다. 포유동물 발현 벡터의 예로는 pCDM8 [Seed, B. (1987) Nature 329:840] 및 pMT2PC [Kaufman et al. (1987) EMBO J. 6:187-195] 등이 있다. 포유동물 세포에서 사용할 경우, 발현 벡터의 제어 기능은 종종 바이러스 조절 요소에 의해 제공된다. 통상 사용되는 프로모터는 예를 들어 폴리오마, 아데노바이러스 2, 사이토메갈로바이러스 및 시미안 바이러스 40에서 유래된 것이다. 원핵 세포 및 진핵 세포에 적합한 다른 발현 시스템에 대해서는 문헌 [Sambrook, J., Fritsch, E.F. and Maniatis, T., Molecular Cloning: A Laboratory Manual, 2ndEdition, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]의 제16장 및 제17장에서 찾을 수 있다.
추가의 실시양태에서, 재조합 포유동물 발현 벡터는 바람직하게는 특정 세포 유형에서 핵산을 발현시킬 수 있다 (예를 들어, 조직-특이적 조절 요소를 사용하여 핵산을 발현시킴). 조직-특이적 조절 요소는 당업계에 공지되어 있다. 적합한 조직-특이적 프로모터의 예로는 알부민 프로모터 (간-특이적; [Pinkert et al. (1987) Genes De. 1:268-277]), 림프양-특이적 프로모터 [Calame and Eaton (1988) Adv. Immunol. 43:235-275], 특히 T-세포 수용체의 프로모터 [Winoto and Baltimore (1989) EMBO J. 8:729-733] 및 이뮤노글로불린의 프로모터 ([Banerji et al. (1983) Cell 33:729-740], [Queen and Baltimore (1983) Cell 33:741-748]), 뉴런-특이적 프로모터 (예컨대 신경필라멘트 프로모터; [Byrne and Ruddle (1989) PNAS 86:5473-5477]), 췌장-특이적 프로모터 [Edlund et al., (1985) Science 230:912-916] 및 유선(乳腺)-특이적 프로모터 (예컨대 유청 프로모터; 미국 특허제4,873,316호 및 유럽 특허 출원 번호 제264,166호) 등이 있으나 이에 제한되지 않는다. 또한, 발생-조절되는 프로모터의 예로는 뮤린 hox 프로모터 [Kessel and Gruss (1990) Science 249:374-379] 및 α-태아단백질 프로모터 [Campes and Tilghman (1989) Genes Dev. 3:537-546] 등이 있다.
추가로, 본 발명은 발현 벡터에 안티센스 방향으로 클로닝된 본 발명의 DNA 분자를 포함하는 재조합 발현 벡터를 제공한다. 이는 DNA 분자가 조절 서열에 기능적으로 연결되어 MCT mRNA에 대해 안티센스인 RNA 분자가 발현 (DNA 분자의 전사를 통해 발현됨)될 수 있음을 의미한다. 안티센스 방향으로 클로닝된 핵산에 기능적으로 결합되고 다수의 세포 유형에서 안티센스 RNA 분자가 지속적으로 발현되도록 제어하는 조절 서열을 선택할 수 있으며, 예를 들어 안티센스 RNA가 구성적으로 조직-특이적 발현되거나 세포 유형-특이적 발현되도록 제어하는 바이러스 프로모터 및(또는) 인핸서 또는 조절 서열을 선택할 수 있다. 안티센스 발현 벡터는 재조합 플라스미드, 파지미드 또는 약독화 바이러스의 형태일 수 있으며, 이는 벡터가 도입된 세포 유형에 따라 활성이 결정되는 고도로 효과적인 조절 영역의 제어하에서 안티센스 핵산을 생산한다. 안티센스 유전자를 이용한 유전자 발현의 조절에 관해서는 문헌 [Weintraub, H. et al., Antisense-RNA as a molecular tool for genetic analysis, Reviews - Trends in Genetics, Vol. 1(1) 1986]에 논의되어 있다.
본 발명의 또다른 측면은 본 발명의 재조합 발현 벡터가 도입된 숙주 세포에 관한 것이다. 본원에서는 용어 "숙주 세포" 및 "재조합 숙주 세포"를 혼용하여 사용한다. 사실상, 이러한 용어는 특정 표적 세포와만 관련된 것이 아니라 그 세포의 자손 또는 잠재적인 자손과도 관련된 것이다. 돌연변이 또는 환경적 요인으로 인해서 특정 변형이 세대에 걸쳐 연속적으로 나타날 수 있기 때문에, 이 자손이 모세포와 반드시 동일한 것은 아니지만, 본원에서 사용된 바와 같이 상기 용어의 범위에 포함되는 것은 마찬가지이다.
숙주 세포는 원핵 세포이거나 진핵 세포일 수 있다. 예를 들면, MCT 단백질은 박테리아 세포, 예를 들어 코리네박테리움 글루타미쿰, 곤충 세포, 효모 또는 포유동물 세포 (예컨대 차이니스 햄스터 난소 (CHO) 세포 또는 COS 세포)에서 발현될 수 있다. 다른 적합한 숙주 세포는 당업자에게 공지되어 있다. 코리네박테리움 글루타미쿰과 관련되어 있고 적합한 방식으로 본 발명의 핵산 분자 및 단백질 분자를 위한 숙주 세포로서 사용될 수 있는 미생물은 표 3에 기재되어 있다.
통상의 형질전환 또는 형질감염 방법을 이용하여 벡터 DNA를 원핵 세포 또는 진핵 세포에 도입할 수 있다. 본원에서 사용된 바와 같이, 용어 "형질전환" 및 "형질감염", "접합" 및 "형질도입"은 외래 핵산 (예컨대 DNA)을 숙주 세포에 도입하는 것과 관련하여 천연 수용법, 화학적 매개 전달법, 인산칼슘 또는 염화칼슘 동시침전법, DEAE-덱스트란-매개된 형질감염법, 리포펙션법 또는 전기천공법 등과 같이 당업계에 공지된 다수의 방법을 포함한다. 숙주 세포의 형질전환 또는 형질감염에 적합한 방법은 문헌 [Sambrook et al., Molecular Cloning: A Laboratory Manual. 2ndEdition, Cold Spring Harbor Laboratory, Cold Spring Harbor LaboratoryPress, Cold Spring Harbor, NY, 1989] 및 다른 실험 안내서에서 찾을 수 있다.
포유동물 세포의 안정한 형질감염의 경우, 사용된 발현 벡터 및 이용된 형질감염 기술에 따라 오직 적은 비율의 세포만이 외래 DNA를 그의 게놈에 통합시킬 수 있음이 공지되어 있다. 통상적으로, 이러한 통합체는 (예컨대 항생제 내성인) 선별가능한 마커를 코딩하는 유전자를 관심 유전자와 함께 숙주 세포에 도입함으로써 확인 및 선별된다. 바람직한 선별가능한 마커로는 G418, 하이그로마이신 및 메토트렉세이트 등과 같은 약물에 내성을 부여하는 유전자 등이 있다. 선별가능한 마커를 코딩하는 핵산을 MCT 단백질을 코딩하는 벡터에 함께 함유시켜서 숙주 세포에 도입하거나, 상기 벡터와는 별개인 벡터를 통해 숙주 세포에 도입할 수 있다. 안정하게 형질감염되어 핵산이 도입된 세포는 예를 들어 약물 선별을 통해 확인할 수 있다 (예를 들어 선별가능한 마커가 통합된 세포는 생존하지만 다른 세포는 사멸함).
상동성 재조합된 미생물을 제조하기 위해서는, MCT 유전자에 결실, 부가 또는 치환을 도입하여 그를 변형시킨, 예를 들어 기능적으로 파괴시킨 하나 이상의 MCT-유전자 절편을 함유하는 벡터를 제조한다. 상기 MCT 유전자는 코리네박테리움 글루타미쿰 MCT 유전자인 것이 바람직하지만, 그와 관련된 박테리아 또는 심지어는 포유동물, 효모 또는 곤충 공급원으로부터의 상동체를 사용할 수도 있다. 바람직한 실시양태에서, 벡터는 상동성 재조합이 내인성 MCT 유전자를 기능적으로 파괴 (즉, 유전자가 더이상 기능적 단백질을 코딩하지 않게됨; "녹아웃 (knockout) 벡터"라고 지칭하기도 함)하도록 고안될 수 있다. 별법으로, 벡터는 상동성 재조합 돌연변이체 등이 내인성 MCT 유전자를 변형시키지만 여전히 기능적 단백질을 코딩하도록 고안될 수 있다 (예를 들어, 상류에 위치한 조절 영역을 변형시킴으로써 내인성 MCT 단백질의 발현이 변형되도록 할 수 있음). 상동성 재조합 벡터 내에 존재하는 변형된 MCT-유전자 절편의 5' 및 3' 말단에는 MCT 유전자의 추가 핵산이 플랭킹되어 있는데, 이는 벡터가 수송하는 외인성 MCT 유전자와 미생물의 내인성 MCT 유전자 사이의 상동성 재조합을 가능케 한다. 추가의 플랭킹 MCT 핵산은 내인성 유전자와의 성공적인 상동성 재조합에 충분한 길이이다. 통상적으로, 벡터는 플랭킹 DNA를 1 kb 미만으로 함유한다 (5' 말단 및 3' 말단 모두에서) (상동성 재조합 벡터에 관해서는 예를 들어 문헌 [Thomas, K.R. and Capecchi, M.R. (1987) Cell 51:503]의 기재 참조). 벡터를 미생물에 도입 (예를 들어 전기천공법에 의한 도입)하고, 도입된 MCT 유전자가 내인성 MCT 유전자와 상동성 재조합된 세포를 당업계에 공지된 방법으로 선별한다.
또다른 실시양태에서, 도입된 유전자의 발현을 조절할 수 있는 것으로 선택한 시스템을 함유하는 재조합 미생물을 생산할 수 있다. 벡터로의 MCT 유전자 삽입은 상기 유전자가 lac 오페론의 제어를 받게 하기 때문에, 예를 들어 MCT-유전자 발현이 IPTG의 존재하에서만 가능해 진다. 이러한 조절 시스템은 당업계에 공지되어 있다.
본 발명의 숙주 세포, 예를 들어 배양된 원핵 세포 또는 진핵 숙주 세포를 사용하여 MCT 단백질을 생산할 수 있다 (즉, 발현시킬 수 있음). 추가로, 본 발명은 본 발명의 숙주 세포를 이용한 MCT 단백질의 생산 방법을 제공한다. 한 실시양태에서, 상기 방법은 본 발명의 숙주 세포 (MCT 단백질을 코딩하는 재조합 발현 벡터가 도입되어 있거나 그의 게놈에 야생형 또는 변형된 MCT 단백질을 코딩하는 유전자가 도입되어 있음)를 적합한 배지 중에서 MCT 단백질이 생산될 때까지 배양하는 단계를 포함한다. 추가의 실시양태에서, 상기 방법은 상기 배지 또는 숙주 세포로부터 MCT 단백질을 단리하는 단계를 포함한다.
C. 본 발명의 용도 및 방법
본원에 기재한 핵산 분자, 단백질, 단백질 상동체, 융합 단백질, 프라이머, 벡터 및 숙주 세포는 하기한 방법 중 하나 이상에서 사용할 수 있다: 코리네박테리움 글루타미쿰 및 그와 관련된 유기체의 확인, 코리네박테리움 글루타미쿰과 관련이 있는 유기체의 게놈 맵핑, 코리네박테리움 글루타미쿰 관심 서열의 확인 및 위치분석, 진화 연구, 기능수행에 필요한 MCT 단백질 영역의 결정, MCT 단백질의 활성 조정; 하나 이상의 대사 경로의 활성 조정 및 관심 화합물, 예컨대 정밀 화학물질의 세포내 생산 조정. 본 발명의 MCT 핵산 분자에는 여러가지 용도가 있다. 첫째로, 이들은 코리네박테리움 글루타미쿰 또는 그와 밀접한 관련이 있는 유기체의 확인에 이용될 수 있다. 또한, 이들은 미생물들이 혼합된 집단 내에서 코리네박테리움 글루타미쿰 또는 그와 관련된 유기체를 확인하는데 사용될 수 있다. 본 발명은 매우 다양한 코리네박테리움 글루타미쿰 유전자의 핵산 서열을 제공한다. 1종 미생물의 집단 또는 미생물들이 혼합된 집단의 배양물에서 추출한 게놈 DNA를 엄격 조건하에서 코리네박테리움 글루타미쿰에 고유한 유전자 영역을 포함하는 프로브로 프로빙함으로써 상기 유기체의 존재 여부를 결정할 수 있다. 코리네박테리움 글루타미쿰 자체는 병원성이 아니지만, 코리네박테리움 디프테리애 등과 같은 병원성 종과 관련이 있다. 이러한 유기체의 검출은 실질적인 임상적 중요성을 갖는다.
본 발명의 핵산 및 단백질 분자는 게놈의 특정 영역의 마커로 기능을 한다. 이러한 기능은 게놈 맵핑뿐 아니라 코리네박테리움 글루타미쿰 단백질의 기능 연구에서도 유용성이 있다. 예를 들어, 코리네박테리움 글루타미쿰 게놈을 절단하여 단편을 DNA 결합 단백질과 인큐베이션시켜, 코리네박테리움 글루타미쿰의 특정 DNA 결합 단백질이 결합하는 게놈 영역을 확인할 수 있다. 단백질에 결합하는 영역은 또한 본 발명의 핵산 분자, 바람직하게는 용이하게 검출할 수 있는 표지로 탐침할 수 있다. 이와 같은 게놈 단편에 대한 핵산 분자의 결합으로 코리네박테리움 글루타미쿰의 게놈 맵에 단편의 위치를 정할 수 있으며, 상이한 효소로 여러번 수행하는 경우 단백질이 결합하는 핵산 서열을 신속하고 용이하게 결정한다. 또한, 본 발명의 핵산 분자는 연관된 종의 서열과 충분한 상동성을 가질 수 있어 브레비박테리움 락토페르멘툼 (Brevibacterium lactofermentum)과 같은 연관된 박테리아의 게놈 맵을 작성하기 위한 마커로 사용할 수 있다.
또한, 본 발명의 MCT 핵산 분자는 진화 연구 및 단백질 구조 연구에도 적합하다. 여러 원핵 세포 및 진핵 세포는 본 발명의 분자가 관여하는 대사 과정을 이용한다. 본 발명의 핵산 분자 서열을 다른 유기체에서의 유사 효소를 코딩하는 핵산 분자 서열과 비교함으로써 상기 유기체의 진화 관계 정도를 조사할 수 있다. 따라서, 이러한 비교를 통해 서열 영역이 보존되었는지의 여부를 결정할 수 있고, 이는 효소 기능에 필수적인 단백질의 보존 영역을 조사하는데 도움을 줄 수 있다.이러한 방식의 조사는 단백질 조작 연구에 중요하며, 단백질에서 그의 기능 손실 없이 돌연변이유발을 허용할 수 있는 수준에 관한 지침을 제공할 수 있다.
본 발명의 MCT 핵산 분자의 유전자 조작을 통해, 야생형 MCT 단백질과는 기능적으로 상이한 MCT 단백질이 생산되도록 할 수 있다. 이러한 단백질은 효율 또는 활성과 관련하여 개선될 수 있어서, 이들이 세포 내에 통상적인 수보다 더 많은 수로 존재하게 하거나 이들의 효율 또는 활성을 약화시킬 수도 있다.
본 발명의 MCT 단백질의 변형에 의해 상기 변형된 단백질을 포함하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질의 수율, 생산 및(또는) 생산 효율에 직접적으로 영향을 줄 수 있는 여러 기작이 있다. 코리네박테리움 글루타미쿰의 대규모 배양으로부터 정밀 화학물질 화합물의 회수는 코리네박테리움 글루타미쿰이 목적 화합물들을 분비하는 경우 상당히 향상되는데, 이는 이 화합물이 배양 배지로부터 (코리네박테리움 글루타미쿰 세포의 집단으로부터 추출한 것과는 반대로) 쉽게 정제될 수 있기 때문이다. 세포로부터 정밀 화학물질을 배출하는 트랜스포터 분자의 수 또는 활성을 증가시킴으로써, 세포외 배지 중에 존재하는 생산된 정밀 화학물질의 양을 증가시키고, 따라서 더 쉽게 수획 및 정제할 수 있다. 반대로, 1종 이상의 정밀 화학물질을 효과적으로 과다생산하기 위해서는, 보조인자, 전구체 분자, 및 적절한 생합성 경로를 위한 중간체 화합물의 양을 증가시키는 것이 필요하다. 따라서, 탄소 공급원 (즉, 당), 질소 공급원 (즉, 아미노산, 암모늄 염), 포스페이트, 및 황 등의 영양분의 유입에 관여하는 트랜스포터 단백질의 수 및(또는) 활성을 증가시킴으로써, 생합성 과정에서 임의 영양분 공급의 제한의 제거로인해, 정밀 화학물질의 생산을 증가시킬 수 있다. 또한, 지방산 및 지질은, 이러한 화합물의 생합성에 관여하는 본 발명의 1종 이상의 MCT 단백질의 활성을 최적화하거나 그의 수를 증가시킴으로써 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 감소시킴으로써, 그 자체로 바람직한 정밀 화학물질이며, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
본 발명의 하나 이상의 MCT 유전자의 조작은 코리네박테리움 글루타미쿰으로부터 하나 이상의 목적하는 정밀 화학물질의 생산에 간접적으로 영향을 주는 변형된 활성을 갖는 MCT 단백질을 생성시킬 수도 있다. 예를 들어, 정상적인 생화학적 대사 과정은 이 동일한 대사 과정을 활성적으로 방해할 수 있는 다양한 폐 생성물 (예를 들어, 과산화수소 및 기타 반응성 산소 종)을 생성시킨다 (예를 들어, 페록시니트리트는 티로신 측쇄를 질소화함으로써 활성 부위내에 티로신을 갖는 몇몇 효소를 실활화하는 것으로 알려져 있다 (Groves, J.T. (1999) Curr. Opin. Chem. Biol. 3(2):226-235)). 이러한 폐 생성물은 통상적으로 배출되며, 대규모 발효 생산에 이용되는 코리네박테리움 글루타미쿰 균주는 1종 이상의 정밀 화학물질의 과다생산을 위해 최적화됨으로써 야생형 코리네박테리움 글루타미쿰에서 통상적으로 생산되는 것보다 더 많은 폐 생성물을 생산할 수 있다. 폐 생성물 분자의 배출에 관여하는 하나 이상의 본 발명의 MCT 분자의 활성을 최적화함으로써, 세포의 생존율을 향상시키고 효과적인 대사 활성을 유지할 수 있다. 또한, 세포내에서 높은 수준으로 존재하는 목적 정밀 화학물질은 실제로 세포에 독성을 띨 수 있어서, 이러한 화합물을 분비하는 세포의 활성을 증가시킴으로써 세포의 생존율을 향상시킬 수 있다.
또한, 적절한 양의 여러 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을 조작할 수 있다. 이는 세포막의 지질 조성에 상당한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가질 수 있기 때문에, 막 지질 조성의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성의 변화는 막을 통한 분자의 수송에 영향을 줄 수 있으며, 이는 상기에서 설명한 바와 같이 폐 생성물 또는 생성된 정밀 화학물질의 유출 또는 필수 영양분의 유입을 변화시킬 수 있다. 이러한 막 유동성의 변화는 세포의 일체성에 상당한 영향을 줄 수도 있으며, 비교적 약한 막을 갖는 세포는 대규모 발효기 환경에서 세포를 손상시키거나 사멸시킬 수 있는 기계적 응력에 대해 보다 치명적이게 된다. 생성된 막이 정밀 화학물질을 생산하는데 이용되는 배양물에 존재하는 환경 조건에 대해 보다 적합하도록 막 구성을 위한 지방산 및 지질의 생산에 관여하는 MCT 단백질을 조작함으로써, 더 높은 비율이 코리네박테리움 글루타미쿰이 생존하고 증식하게 된다. 배양물 중 더 많은 수의 코리네박테리움 글루타미쿰은 배양물로부터 정밀 화학물질의 수율, 생산 또는 생산 효율을 더 크게 증가시킨다.
MCT 단백질이 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 수율을 증가시키기 위한 상기한 돌연변이유발 방법은 한정적이지 않으며, 이러한 방법의 변형은 당업자에게 자명할 것이다. 이러한 방법의 이용, 본원에 개시된 기작의 포함, 본 발명의 핵산 및 단백질 분자를 돌연변이된 MCT 핵산 및 단백질 분자를 발현하는 코리네박테리움 글루타미쿰 또는 연관 균주의 제조에 이용하여 목적하는 화합물의 수율, 생산 및(또는) 생산 효율을 향상시킨다. 상기 목적하는 화합물은 생합성 경로의 최종 산물 및 천연 대사 경로의 중간체뿐 아니라 코리네박테리움 글루타미쿰 대사에서는 본래 일어나지 않으나 본 발명의 코리네박테리움 글루타미쿰 균주에 의해 생산되는 분자를 포함한 코리네박테리움 글루타미쿰에 의해 생산되는 모든 산물이 될 수 있다.
하기 실시예는 본 발명을 추가로 예시하기 위한 것으로써, 본 발명을 제한하는 것으로 이해해서는 안된다. 본 명세서에서 인용한 모든 참고문헌, 특허 출원 명세서, 특허 문헌 및 공개된 특허 출원 명세서의 내용은 본원에 참고로 도입된다.
실시예 1: 코리네박테리움 글루타미쿰 ATCC13032의 전체 게놈 DNA의 제조
BHI 배지 (디프코 (Difco) 제품) 중의 코리네박테리움 글루타미쿰 (ATCC 13032) 배양물을 30℃에서 격렬히 진탕시키면서 밤새 배양하였다. 원심분리하여 세포를 회수하여 상층액은 버리고, 세포를 완충액-I 5 mL (배양물 처음 부피의 5％에 해당함-언급한 모든 부피는 배양 부피 100 mL에 대해 계산한 값임) 중에 재현탁했다. 완충액-I의 조성은 다음과 같았다: 140.34 g/L 수크로스, 2.46 g/L MgS04×7 H2O, 10 mL/L KH2PO4용액 (100 g/L, KOH를 사용하여 pH 6.7로 조정함), 50 mL/L M12 농축물 (10 g/L (NH4)2SO4, 1 g/L NaCl, 2 g/L MgSO4×7 H2O, 0.2 g/L CaCl2, 0.5 g/L 효모 추출물 (디프코 제품), 10 mL/L 미량 원소 혼합물 (200 mg/L FeSO4×H2O, 10 mg/L ZnSO4×7 H2O, 3 mg/L MnCl2×4 H2O, 30 mg/L H3BO3, 20 mg/L CoCl2×6 H2O, 1 mg/L NiCl2×6 H2O, 3 mg/L Na2MoO4×2 H2O), 500 mg/L 착화제 (EDTA 또는 시트르산), 100 mL/L 비타민 혼합물 (0.2 mg/L 바이오틴, 0.2 mg/L 엽산, 20 mg/L p-아미노 벤조산, 20 mg/L 리보플라빈, 40 mg/L Ca 판토테네이트, 140 mg/L 니코틴산, 40 mg/L 피리독살 히드로클로라이드, 200 mg/L 미오이노시톨). 상기 현탁액에 리소짐을 최종 농도 2.5 mg/mL로 첨가했다. 37℃에서 대략 4시간 동안 인큐베이션시킨 후, 세포벽을 파괴하고 원심분리하여 원형질체를 수거했다. 펠렛을 완충액-I 5 mL로 1회 세척하고, TE 완충액 (10 mM Tris-HCl, 1 mM EDTA, pH 8) 5 mL로 1회 세척했다. 펠렛을 TE 완충액 4 mL 중에 재현탁하고, SDS 용액 (10％) 0.5 mL 및 NaCl 용액 (5 M) 0.5 mL을 첨가했다. 프로테이나제 K를 최종 농도 200 ㎍/mL로 첨가한 후, 상기 현탁액을 37℃에서 대략 18시간 동안 인큐베이션시켰다. 표준 방법에 따라 DNA를 페놀, 페놀/클로로포름/이소아밀 알콜 및 클로로포름/이소아밀 알콜로 추출하여 정제했다. 이어서, 1/50배 부피의 3 M 아세트산나트륨 및 2배 부피의 에탄올을 첨가하여 DNA를 침전시킨 후, -20℃에서 30분 동안 인큐베이션시키고, SS34 회전자 (소르발 (Sorvall) 제품)를 사용한 고속 원심분리기에서 12,000 rpm로 30분 동안 원심분리했다. DNA를 20 ㎍/mL RNaseA를 함유하는 TE 완충액 1 mL 중에 용해시키고, 4℃에서 3시간 이상 동안 TE 완충액 1000 mL 중에 투석했다. 투석 동안, 상기 완충액을 3회 교환하였다. 투석된 DNA 용액을 0.4 mL씩 분취하여, 2 M LiCl 0.4 mL 및 에탄올 0.8 mL을 첨가했다. -20℃에서 30분 동안 인큐베이션시킨후, 원심분리 (13,000 rpm, 독일 하나우 헤래우스에 소재하는 바이오퓨지 프레스코 (Biofuge Fresco) 제품)하여 DNA를 수집했다. DNA 펠렛을 TE 완충액 중에 용해했다. 이 방법으로 제조된 DNA를 서던 블롯팅 또는 게놈 뱅크 제작 등의 모든 목적에 이용했다.
실시예 2: 대장균에서 코리네박테리움 글루타미쿰 (ATCC13032)의 게놈 뱅크 제작
실시예 1에 기재한 바와 같이 제조된 DNA를 사용하여, 공지되고 확립되어 있는 방법 (예를 들어 문헌 [Sambrook, J. et al. (1989) "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley ＆ Sons] 참조)에 따라 코스미드 및 플라스미드 뱅크를 제작했다.
임의의 플라스미드 또는 코스미드를 사용할 수 있었다. 특히, 플라스미드 pBR322 [Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75:3737-3741]; pACYC177 [Change ＆ Cohen (1978) J. Bacteriol 134:1141-1156], pBS 계열의 플라스미드 (pBSSK+, pBSSK- 등; 미국 라졸라에 소재하는 스트라타진 (Stratagene) 제품) 또는 SuperCos I (미국 라졸라에 소재하는 스트라타진 제품) 또는 Lorist6 [Gibson, T.J., Rosenthal A. and Waterson, R.H. (1987) Gene 53:283-286] 등의 코스미드를 사용하는 것이 바람직했다.
실시예 3: DNA 서열분석 및 컴퓨터를 이용한 기능 분석
실시예 2에 기재한 바와 같은 게놈 뱅크를 사용하여, 표준 방법, 특히 ABI377 서열 분석기를 사용한 쇄 종결 방법 (예를 들어 문헌 [Fleischman, R.D. etal. (1995) "Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd.", Science, 269:496-512])에 따른 DNA 서열분석을 수행했다. 하기 뉴클레오티드 서열을 갖는 서열분석 프라이머를 사용했다: 5'-GGAAACAGTATGACCATG-3' 또는 5'-GTAAAACGACGGCCAGT-3'.
실시예 4: 생체내 돌연변이유발
코리네박테리움 글루타미쿰의 생체내 돌연변이유발은 유전 정보의 통합성을 유지할 수 없는 대장균 또는 다른 미생물 (예를 들면, 바실러스 종 또는 사카로마이세스 세레비지애 등의 효모)에 플라스미드 (또는 다른 벡터) DNA를 계대배양하여 수행할 수 있다. 전형적인 돌연변이유발 균주는 DNA 복구 시스템에 관한 유전자 (예를 들면, mutHLS, mutD, mutT 등; 비교하기 위해서는 문헌 [Rupp, W.D. (1996) DNA repair mechanisms, in Escherichia coli and Salmonella, pp. 2277-2294, ASM: Washington] 참조)에 돌연변이가 있다. 이러한 균주들은 당업자에게 공지되어 있다. 이러한 균주의 사용법은 예를 들어 문헌 [Greener, A. and Callahan, M. (1994) Strategies 7:32-34]에 예시되어 있다.
실시예 5: 대장균과 코리네박테리움 글루타미쿰 사이의 DNA 전달
여러 코리네박테리움 및 브레비박테리움 종은 자율적으로 복제되는 내인성 플라스미드 (예를 들면, pHM1519 또는 pBL1 등)를 함유하고 있다 (이에 관해 검토하기 위해서는 예를 들어 문헌 [Martin, J.F. et al. (1987) Biotechnology, 5:137-146] 참조). 대장균 및 코리네박테리움 글루타미쿰에 사용하기 위한 셔틀 벡터는 대장균의 경우에 사용하는 표준 벡터 (문헌 [Sambrook, J. et al. (1989),"Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley ＆ Sons])에 코리네박테리움 글루타미쿰의 복제 기점 및 적당한 마커를 부가하여 사용함으로써 쉽게 제작될 수 있다. 이러한 복제 기점은 코리네박테리움 및 브레비박테리움 종에서 단리한 내인성 플라스미드로부터 얻는 것이 바람직하다. 이들 종에 특히 유용한 형질전환 마커는 카나마이신 내성 유전자 (예를 들면, Tn5 또는 Tn903 트란스포손에서 유래함) 또는 클로람페니콜 내성 유전자 [Winnacker, E.L. (1987) "From Genes to Clones-Introduction to Gene Technology", VCH, Weinheim]이다. 대장균 및 코리네박테리움 글루타미쿰에서 복제되고 유전자 과다발현을 비롯한 각종 목적에 사용할 수 있는 매우 다양한 셔틀 벡터의 제조법에 관한 문헌들이 많이 있다 (예를 들어 [Yoshihama, M. et al. (1985) J. Bacteriol. 162:591-597], [Martin J.F. et al. (1987) Biotechnology, 5:137-146] 및 [Eikmanns, B.J. et al. (1991) Gene, 102:93-98] 참조).
표준 방법을 이용하여, 관심 유전자를 상기 기재한 셔틀 벡터들 중 하나에 클로닝하고 이러한 하이브리드 벡터를 코리네박테리움 글루타미쿰 균주에 도입할 수 있다. 코리네박테리움 글루타미쿰은 원형질체 형질전환법 [Kastsumata, R. et al. (1984) J. Bacteriol. 159:306-311], 전기천공법 [Liebl, E. et al. (1989) FEMS Microbiol. Letters, 53:399-303]을 이용하고 특정 벡터가 사용되는 경우에는 접합법 (예를 들어 문헌 [Schaefer, A et al. (1990) J. Bacteriol. 172:1663-1666]에 기재된 바와 같음)도 이용하여 형질전환시킬 수 있다. 또한, 코리네박테리움 글루타미쿰으로부터 플라스미드 DNA를 제조 (당업계에 공지된 표준 방법을 사용함)하고, 이것으로 대장균을 형질전환시켜 코리네박테리움 글루타미쿰의 셔틀 벡터를 대장균에 전달할 수도 있다. 이러한 형질전환 단계는 표준 방법으로 수행할 수 있지만, NM522 [Gough ＆ Murray (1983) J. Mol. Biol. 166:1-19] 등과 같은 Mcr-결핍 대장균 균주를 사용하는 것이 유리하다.
실시예 6: 돌연변이된 단백질의 발현 측정
형질전환된 숙주 세포에서 돌연변이된 단백질의 활성 관찰은 상기 돌연변이 단백질이 야생형 단백질과 유사한 방식 및 유사한 양으로 발현된다는 사실을 바탕으로 한다. 돌연변이된 유전자의 전사량 (유전자 생성물의 번역에 이용가능한 mRNA 양에 관한 지표) 측정에 적합한 방법은 관심 유전자에 결합하도록 고안되어 검출가능한 표지 (통상적으로 방사성 표지 또는 화학발광 표지)가 부착된 프라이머를 사용하여 노던 블롯팅 (예를 들어 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York] 참조)을 수행하는 것인데, 이는 유기체 배양물의 전체 RNA를 추출하고 겔상에서 분리하여 안정한 매트릭스에 옮긴 후에 상기 프로브와 인큐베이션시켜, 프로브의 결합 및 그 결합 활성이 상기 유전자에 대한 mRNA의 존재 여부 및 또한 그 존재량을 지시하는 방법이다. 이러한 정보는 돌연변이된 유전자의 전사 정도에 관한 지표가 된다. 예를 들어 문헌 [Bormann, E.R. et al. (1992) Mol. Microbiol. 6:317-326]에 기재된 것과 같이 당업계에 공지된 각종 방법들을 이용하여 코리네박테리움 글루타미쿰의 세포내 전체 RNA를 단리할 수 있다.
상기 mRNA로부터 번역된 단백질의 존재 여부 또는 그 상대량은 웨스턴 블롯팅과 같은 표준 기술을 사용하여 측정할 수 있다 (예를 들어 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York] 참조). 이 방법에서는, 세포내 전체 단백질을 추출하여 겔 전기영동법으로 분리한 후에 이를 니트로셀룰로스 등과 같은 매트릭스에 옮겨서 관심 단백질에 특이적으로 결합하는 항체 등과 같은 프로브와 함께 인큐베이션시킨다. 통상적으로, 이 프로브에는 쉽게 검출될 수 있는 화학발광 표지 또는 비색 표지가 부착되어 있다. 표지의 존재 여부 및 그의 관찰된 양은 그 세포 내에서 원하는 돌연변이 단백질의 존재 여부 및 그 존재량을 지시한다.
실시예 7: 유전자 변형된 코리네박테리움 글루타미쿰의 성장 - 배지 및 배양 조건
유전자 변형된 코리네박테리움을 합성 또는 천연 성장 배지에서 배양한다. 코리네박테리움을 위한 여러 다양한 성장 배지는 당업계에 공지되어 있으며 쉽게 입수가능하다 (문헌 [Lieb et al. (1989) Appl. Microbiol. Biotechnol. 32:205-210], [von der Osten et al. (1998) Biotechnology Letters, 11:11-16], 독일 특허 제4,120,867호, [Liebl (1992) "The Genus Corynebacterium", in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag]). 이들 배지는 1종 이상의 탄소 공급원, 질소 공급원, 무기염, 비타민 및 미량 원소로 구성된다. 바람직한 탄소 공급원은 단당류, 이당류 또는 다당류 등의 당이다. 매우 훌륭한 탄소 공급원의 예로는 글루코스, 프럭토스, 만노스, 갈락토스, 리보스, 소르보스, 리불로스, 락토스, 말토스, 수크로스, 라피노스, 녹말 및 셀룰로스 등이 있다. 또한, 당 정제시 생성되는 당밀 또는 기타 부산물 등과 같은 복합 화합물 등으로서 배지에 당을 공급할 수도 있다. 또한, 각종 탄소 공급원들의 혼합물을 첨가하는 것이 유리할 수도 있다. 다른 가능한 탄소 공급원은 메탄올, 에탄올, 아세트산 또는 락트산 등의 알콜 및 유기산이다. 질소 공급원은 통상적으로 유기 또는 무기 질소 화합물이거나 이러한 화합물을 함유하는 물질이다. 질소 공급원의 예로는 암모니아 기체 및 NH4Cl 또는 (NH4)2SO4, NH40H 등의 암모늄염, 질산염, 우레아, 아미노산 또는 옥수수 침지액, 대두 가루, 대두 단백질, 효모 추출물, 육류 추출물 등과 같은 복합 질소 공급원 등이 있다.
배지에 함유시킬 수 있는 무기 염 화합물로는 칼슘, 마그네슘, 나트륨, 코발트, 몰리브덴, 칼륨, 망간, 아연, 구리 및 철의 염산염, 인산염 또는 황산염 등이 있다. 킬레이팅제를 배지에 첨가하여 금속 이온을 용액 중에 유지할 수 있다. 특히 적합한 킬레이팅제로는 카테콜 또는 프로토카테쿠에이트 등과 같은 디히드록시페놀 또는 시트르산 등의 유기산 등이 있다. 또한, 배지에는 통상적으로 비타민 또는 성장 촉진제 등의 다른 성장 인자가 함유되어 있고, 이들의 예로는 바이오틴, 리보플라빈, 티아민, 엽산, 니코틴산, 판토테네이트 및 피리독신 등이 있다. 성장 인자 및 염은 흔히 효모 추출물, 당밀, 옥수수 침유 등과 같은 복합 배지 성분으로부터 생성된다. 배지의 정확한 조성은 특정 실험마다 크게 달라지고, 각 경우마다 따로 결정된다. 배지의 최적화에 관한 정보는 문헌 ["Applied Microbiol. Physiology, A Practical Approach (editors P.M. Rhodes, P.F. Stanbury, IRLPress (1997) pp.53-73, ISBN 0 19 963577 3)]에서 찾을 수 있다. 또한, 스탠다드 1 (Standard 1) (머크 (Merck) 제품) 또는 BHI (BrainHeartInfusion, 디프코 제품) 등과 같이 제조 회사가 시판하는 것을 구입할 수도 있다.
모든 배지 성분들을 열처리 (1.5 bar 및 121℃에서 20분) 또는 멸균 여과로 멸균시킨다. 이 성분들은 한꺼번에 멸균시킬 수도 있고 필요에 따라서는 따로 멸균시킬 수도 있다. 모든 배지 성분들은 배양 초기부터 함유시킬 수도 있고, 원한다면 연속적으로 또는 배치식으로 첨가할 수도 있다.
배양 조건은 각 실험마다 따로 정의된다. 온도는 15℃와 45℃ 사이의 범위이어야 하고, 실험하는 동안 일정하게 유지시키거나 변경시킬 수 있다. 배지의 pH는 5 내지 8.5의 범위, 바람직하게는 약 7.0 정도이어야 하며, 배지에 완충액을 첨가하여 유지시킬 수 있다. 이러한 목적으로 사용할 수 있는 완충액의 예로는 인산칼륨 완충액 등이 있다. MOPS, HEPES, ACES 등과 같은 합성 완충액을 대안적으로 사용하거나 동시에 사용할 수 있다. 또한, 배양하는 동안 NaOH 또는 NH4OH를 첨가하여 pH를 일정하게 유지시킬 수도 있다. 효모 추출물 등의 복합 배지 성분이 사용되는 경우, 많은 복합 화합물들은 완충 성능이 높기 때문에 추가 완충액에 대한 요구를 감소시킬 수 있다. 미생물 배양에 발효기를 사용하는 경우, pH는 암모니아 기체를 사용하여 조절할 수도 있다.
인큐베이션 기간은 통상적으로 수 시간 내지 수 일이다. 이 시간은 브로쓰에 축적되는 생성물의 양이 최대가 되도록 선택한다. 개시한 성장 실험을 다양한크기의 미량역가 플레이트, 유리관, 유리 플라스크 또는 유리 또는 금속 발효기 등의 각종 용기에서 수행할 수 있다. 다수의 클론을 스크리닝하기 위해서는, 미생물을 배플이 있거나 없는 미량역가 플레이트, 유리관 또는 진탕 플라스크에서 배양해야 한다. 요구되는 성장 배지를 100 mL 진탕 플라스크에 10％ (부피 기준) 채워 사용하는 것이 바람직하다. 이 플라스크들은 100 내지 300 rpm 속력 범위의 회전 진탕기 상에서 진탕 (진폭 25 mm)되어야 한다. 대기를 습하게 유지함으로써 증발로 인한 손실량을 감소시키거나, 별법으로는 증발로 인한 손실량을 정확하게 보정해야 한다.
유전자 변형된 클론을 연구하는 경우, 변형되지 않은 대조 클론 또는 인서트가 없는 원래의 플라스미드를 함유하는 대조 클론도 분석해야 한다. CM 플레이트 (10 g/L 글루코스, 2.5 g/L NaCl, 2 g/L 우레아, 10 g/L 폴리펩톤, 5 g/L 효모 추출물, 5 g/L 육류 추출물, 22 g/L 아가, 2 M NaOH을 사용하여 pH 6.8로 조정) 등과 같은 아가 플레이트 상에서 30℃에서 인큐베이션하여 성장시킨 세포를 OD600이 0.5 내지 1.5가 되도록 배지에 접종한다. 배지 접종은 CM 플레이트로부터의 코리네박테리움 글루타미쿰 세포의 염수 용액을 도입하거나, 상기 박테리아의 예비배양액을 첨가하여 수행한다.
실시예 8: 돌연변이된 단백질의 기능에 관한 시험관내 분석
효소의 활성 및 반응 속도 (kinetics) 측정법은 당업계에 공지되어 있다. 특정하게 변형된 효소의 활성 측정 실험은 야생형 효소의 비활성에 맞추어야 하며,당업자라면 이를 잘 수행할 수 있다. 효소에 관한 일반적인 개요 뿐만 아니라 효소의 구조, 반응 속도, 원리, 방법, 적용에 관한 구체적인 세부사항 및 많은 효소들의 활성 측정 방법의 예는 예를 들어 하기의 참고문헌에서 찾을 수 있다: [Dixon, M., and Webb, E.C.: (1979) Enzymes. Longmans: London; Fersht (1985) Enzyme Structure and Mechanism. Freeman, New York], [Walsh (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco], [Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford], [Boyer, P.D., editors (1983) The Enzymes, 3rd edition. Academic Press: New York], [Bisswanger, H., (1994) Enzymkinetik, 2nd edition. VCH: Weinheim (ISBN 3527300325)], [Bergmeyer, H.U., Bergmeyer, J., Grassl, M., editors (1983-1986) Methods of Enzymatic Analysis, 3rd edition, vol. I-XII, Verlag Chemie: Weinheim] 및 [Ullmann's Encyclopedia of Industrial Chemistry (1987) vol. A9, "Enzymes". VCH: Weinheim, pp. 352-363].
DNA에 결합하는 단백질의 활성은 DNA 밴드쉬프트 분석법 (겔 지연 분석법이라고 지칭하기도 함) 등과 같이 잘 확립되어 있는 여러 방법들을 사용하여 측정할 수 있다. 상기 단백질들이 다른 분자들의 발현에 미치는 영향은 리포터 유전자 분석법 (예를 들어 문헌 [Kolmar, H. et al. (1995) EMBO J. 14:3895-3904]과 그의 참고문헌에 기재된 바와 같음)을 사용하여 측정할 수 있다. β-갈락토시다제 등의 효소, 녹색 형광 단백질 및 여러가지 기타 효소가 사용되는 리포터 유전자 시험 시스템은 원핵 세포 및 진핵 세포 모두에의 적용에 대해 공지되어 있으며 잘 확립되어 있다.
막 수송 단백질의 활성은 문헌 [Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, pp. 85-137, 199-234 및 270-322]에 기재된 기술에 따라 측정할 수 있다.
실시예 9: 돌연변이된 단백질이 관심 생성물의 생산에 미치는 영향의 분석
코리네박테리움 글루타미쿰에서의 유전자 변형이 관심 화합물 (예컨대 아미노산)의 생산에 미치는 영향은 변형된 미생물을 적합한 조건 (예를 들어 상기 기재한 조건)하에서 성장시키고, 관심 생성물 (즉, 아미노산)의 생산 증가에 관여한 배지 성분 및(또는) 세포내 성분을 시험하여 결정할 수 있다. 이러한 분석 기술은 당업자에게 익히 공지되어 있으며, 분광분석법, 박층 크로마토그래피법, 각종 유형의 착색법, 효소적 및 미생물학적 방법 및 고성능 액체 크로마토그래피법 등과 같은 분석용 크로마토그래피법 등이 있다 (예를 들어 문헌 ([Ullman, Encyclopedia of Industrial Chemistry, vol. A2, pp. 89-90 및 pp. 443-613, VCH: Weinheim (1985)], [Fallon, A. et al., (1987) "Applications of HPLC in Biochemistry" in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17], [Rehm et al. (1993) Biotechnology, vol. 3, Chapter III: "Product recovery and purification", pp. 469-714, VCH: Weinheim], [Belter, P.A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons], [Kennedy, J.F. and Cabral, J.M.S. (1992) Recovery processes forbiological materials, John Wiley and Sons], [Shaeiwitz, J.A. and Henry, J.D. (1988) Biochemical separations, in Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, pp. 1-27, VCH: Weinheim] 및 [Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications]) 참조).
최종 발효 생성물의 측정 뿐만 아니라, 중간체 및 부산물 등과 같이 관심 화합물의 생산에 이용된 대사 경로 중의 다른 성분들을 분석함으로써 전반적인 화합물 생산 효율을 측정할 수도 있다. 분석 방법으로는 배지 내의 영양분 (예컨대 당, 탄화수소, 질소 공급원, 인산염 및 기타 이온) 함량 측정, 바이오매스의 조성 및 성장 측정, 생합성 경로의 공통 대사물질의 생산 분석 및 발효 동안에 생성된 기체의 측정 등이 있다. 이러한 측정을 위한 표준 방법은 문헌 [Applied Microbial Physiology, A Practical Approach, P.M.Rhodes and P.F.Stanbury, eds., IRL Press, pp. 103-129, 131-163 및 165-192 (ISBN:0199635773)과 그의 참고문헌]에 기재되어 있다.
실시예 10: 코리네박테리움 글루타미쿰 배양물로부터의 관심 생성물의 정제
당업계에 공지된 여러가지 방법을 사용하여, 코리네박테리움 글루타미쿰 세포 또는 상기 기재한 배양물의 상층액으로부터 관심 생성물을 수득할 수 있다. 세포가 관심 생성물을 분비하지 않는 경우에는 배양물을 저속 원심분리하여 세포를 수거하고 기계적인 힘이나 초음파 등과 같은 표준 기술로 세포를 용균시킬 수 있다. 원심분리로 세포 잔해를 제거하여 가용성 단백질을 함유하는 상층액 분획물을수득하고, 이를 사용하여 관심 화합물을 추가로 정제한다. 코리네박테리움 글루타미쿰 세포가 생성물을 분비하는 경우에는 배양물을 저속 원심분리하여 세포를 제거하고, 수득한 상층액 분획물을 추가로 정제한다.
상기 두 가지 정제 방법 모두의 경우에서 수득한 상층액 분획물을 적합한 수지를 사용한 크로마토그래피에 적용하여 관심 분자는 크로마토그래피 수지 상에 남지만 샘플 중의 많은 오염물질들은 남지 않게 하거나, 오염물질들은 수지에 남지만 원하는 분자는 남지 않게 한다. 필요에 따라서는, 동일하거나 상이한 크로마토그래피 수지를 사용하여 이러한 크로마토그래피 단계를 반복할 수 있다. 당업자라면, 적합한 크로마토그래피 수지를 선택하고 정제할 특정 분자에 대해 가장 효과적으로 이를 적용하는 것에 숙달되어 있을 것이다. 정제된 생성물을 여과 또는 한외여과사켜 농축시키고, 생성물의 안정성이 최대가 되는 온도에 저장할 수 있다.
당업계에는 상기 기재한 정제법 및 예를 들어 문헌 [Bailey, J.E. ＆ Ollis, D.F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986)]에 기재된 정제법 등을 포함하나 이에 제한되지 않는 여러가지 정제법들이 공지되어 있다.
단리된 화합물의 확인 및 순도는 당업계의 기술로 측정할 수 있다. 이러한 기술로는 고성능 액체 크로마토그래피법 (HPLC), 분광분석법, 착색법, 박층 크로마토그래피법, NIRS법, 효소 분석법 또는 미생물학적 분석법 등이 있다. 이러한 분석 방법은 하기 문헌에서 고찰된다: [Patek et al. (1994) Appl. Environ. Microbiol. 60:133-140], [Malakhova et al. (1996) Biotekhnologiya 11:27-32],[Schmidt et al. (1998) Bioprocess Engineer. 19:67-70], [Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, pp. 89-90, pp. 521-540, pp. 540-547, pp. 559-566, pp. 575-581 및 pp. 581-587], [Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons] 및 [Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17].
등가물
당업자라면, 단순한 통상의 방법을 이용하여 본 발명의 특정 실시양태의 수많은 등가물을 알아내거나 확인할 수 있다. 이러한 등가물은 하기한 청구의 범위에 포함된다.
표 1의 정보는 다음과 같이 이해되어야 한다:
컬럼 1에서, "DNA 서열 번호"의 해당 번호는 첨부된 서열 목록에서의 서열 번호 각각을 지칭하는 것이다. 따라서, 컬럼 "DNA 서열 번호"의 "5"는 서열 5를 지칭한다.
컬럼 2에서, "아미노산 서열 번호"의 해당 번호는 첨부된 서열 목록에서의 서열 번호 각각을 지칭하는 것이다. 따라서, 컬럼 "아미노산 서열 번호"의 "6"은 서열 6을 지칭한다.
컬럼 3에서, "확인"은 각 서열에 대한 명확한 내부 명칭을 기재한 것이다.
컬럼 4에서, "아미노산 위치"의 해당 번호는 각 경우에서 동일 열에 있는 "아미노산 서열 번호"에 기재된 폴리펩티드 서열에서의 아미노산 위치를 지칭한다. 따라서, 컬럼 "아미노산 위치"의 "26"은 해당 폴리펩티드 서열의 아미노산 위치 26이다. 위치 번호는 N 말단을 +1로 하여 출발한다.
컬럼 5에서, "아미노산 야생형"의 해당 문자는 각 경우의 컬럼 4에 표시한 야생형 서열에서 해당 위치에 존재하는 아미노산을 지칭하며, 1문자 코드로 나타내었다.
컬럼 6에서, "아미노산 돌연변이체"의 해당 문자는 각 경우의 컬럼 4에 표시한 돌연변이체 서열에서 해당 위치에 존재하는 아미노산을 지칭하며, 1문자 코드로 나타내었다.
컬럼 7에서, "기능"은 해당 폴리펩티드 서열의 생리적 기능을 기재한 것이다.
단백질원성 아미노산의 1문자 코드는 다음과 같다:
A 알라닌
C 시스테인
D 아스파르트산
E 글루탐산
F 페닐알라닌
G 글리신
H 히스티딘
I 이소루이신
K 리신
L 루이신
M 메티오닌
N 아스파라긴
P 프롤린
Q 글루타민
R 아르기닌
S 세린
T 트레오닌
V 발린
W 트립토판
Y 티로신
SEQUENCE LISTING <110> BASF Aktiengesellschaft <120> Genes coding for membrane synthesis and membrane transport proteins <130> O.Z. 0050/52972 <160> 214 <210> 1 <211> 1978 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1948) <223> RXA00149 <400> 1 ttttcgtagg taaacacagg tgaaggcttt acaagcttgt gaactcccta cacaaaagca 60 atccaatagc tatccataag caagagaaag taagtctacg ttg act gat ctc aca 115 Leu Thr Asp Leu Thr 1 5 aag act gcg gtg ccc gag gaa ctt tca gag aac ctc gaa act tgg tac 163 Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn Leu Glu Thr Trp Tyr 10 15 20 aag gct gtg gcc ggt gtt ttc gcg cgc aca cag aaa aaa gac atc ggc 211 Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln Lys Lys Asp Ile Gly 25 30 35 gac att gcc gta gat gtg tgg aag aaa ctc atc gtc act aca ccg gat 259 Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile Val Thr Thr Pro Asp 40 45 50 ggt gtt gat atc aat ccg ctg tac acc aga gca gat gag tcc cag agg 307 Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala Asp Glu Ser Gln Arg 55 60 65 aaa ttc act gag gtt cct ggt gag ttt ccc ttc act agg gga acc act 355 Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe Thr Arg Gly Thr Thr 70 75 80 85 gtt gat ggt gaa cgc gtt ggt tgg ggt gtt act gag act ttc gga cat 403 Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr Glu Thr Phe Gly His 90 95 100 gac agc ccg aag aat atc aac gct gcg gtg ctg aat gct ctg aat tct 451 Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu Asn Ala Leu Asn Ser 105 110 115 ggc acc acc aca ttg ggt ttt gag ttc tct gag gaa ttc acg gca gct 499 Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu Glu Phe Thr Ala Ala 120 125 130 gat ctt aaa gtt gct ctc gaa ggc gtg tat ctc aac atg gct ccg ttg 547 Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu Asn Met Ala Pro Leu 135 140 145 ctg att cat gcg ggt gga tcc acg tca gag gtt gca gcg gcg ttg tat 595 Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val Ala Ala Ala Leu Tyr 150 155 160 165 acg ttg gcg gag gaa gcc gga acg ttt ttt gct gcg ttg acc ttg ggt 643 Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala Ala Leu Thr Leu Gly 170 175 180 tct cgt cct ttg acg gcg cag gtt gat ggt tcg cac agt gac acc att 691 Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser His Ser Asp Thr Ile 185 190 195 gaa gaa gca gtt cag ttg gca gtg aat gct tcc aag cgt gcg aat gtg 739 Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser Lys Arg Ala Asn Val 200 205 210 cgc gct atc ttg gtg gat ggt tcc agt ttt tcc aac cag ggc gcg tcg 787 Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser Asn Gln Gly Ala Ser 215 220 225 gat gct caa gaa att ggt cta agt atc gcc gcc ggt gtg gat tat gtc 835 Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala Gly Val Asp Tyr Val 230 235 240 245 cgt cgc ttg gtc gat gca ggc ctt tcc acg gaa gct gca ctt aag cag 883 Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu Ala Ala Leu Lys Gln 250 255 260 gtg gcg ttc cgt ttt gcg gtc acc gat gag cag ttc gcg cag att tct 931 Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln Phe Ala Gln Ile Ser 265 270 275 aag ctg cgt gtg gct cga cgt ctg tgg gcc agg gtg tgt gag gtg ctt 979 Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg Val Cys Glu Val Leu 280 285 290 ggt ttt cca gag ctg gcc gta gca cca cag cat gcg gtg act gca cga 1027 Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His Ala Val Thr Ala Arg 295 300 305 gcg atg ttt agc cag cgt gat ccg tgg gtg aat atg ctg cgc agt act 1075 Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn Met Leu Arg Ser Thr 310 315 320 325 gtt gca gct ttc gct gca ggc gtc ggt gga gca acc gat gtg gag gtt 1123 Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala Thr Asp Val Glu Val 330 335 340 cgt act ttt gat gat gcg atc cca gat gga gtt cct gga gtg tcg agg 1171 Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val Pro Gly Val Ser Arg 345 350 355 aat ttc gct cac cgc atc gcg cgc aat act aat ttg ttg ttg cta gaa 1219 Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn Leu Leu Leu Leu Glu 360 365 370 gag tca cat ctt ggt cac gtg gtt gat cct gct ggt gga tca tat ttc 1267 Glu Ser His Leu Gly His Val Val Asp Pro Ala Gly Gly Ser Tyr Phe 375 380 385 gtg gag agc ttc acc gat gat cta gcg gag aag gcg tgg gct gtg ttc 1315 Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys Ala Trp Ala Val Phe 390 395 400 405 agt ggc atc gaa gct gag ggc gga tac agt gca gct tgt gca tcc ggc 1363 Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala Ala Cys Ala Ser Gly 410 415 420 acg gtg act gcc atg ctt gat cag acg tgg gag cag act cgc gct gat 1411 Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu Gln Thr Arg Ala Asp 425 430 435 gtg gcg tcg aga aag aag aag ctc act gga att aat gag ttc ccg aac 1459 Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile Asn Glu Phe Pro Asn 440 445 450 ttg gcg gag tct ccg ctg cca gct gat cgt cgg gta gaa cct gca ggt 1507 Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg Val Glu Pro Ala Gly 455 460 465 gtg cgt cga tgg gca gcg gat ttt gaa gcg ctg cgc aat cgt tcg gat 1555 Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu Arg Asn Arg Ser Asp 470 475 480 485 gct ttc ttg gaa aag aac ggc gcg agg cca cag atc acg atg att cct 1603 Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln Ile Thr Met Ile Pro 490 495 500 ctg gga ccg ttg tcc aag cac aat att cgc act ggt ttt act tcc aac 1651 Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr Gly Phe Thr Ser Asn 505 510 515 ctg ttg gct tcc ggt ggc att gaa gca atc aac ccg ggt caa ctt gtt 1699 Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn Pro Gly Gln Leu Val 520 525 530 ccc ggc act gac gct ttt gca gaa gct gca cag gcc gca ggc att gta 1747 Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln Ala Ala Gly Ile Val 535 540 545 gtg gtg tgt gga acg gac caa gag tat gcc gaa acg ggg gag gga gcc 1795 Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu Thr Gly Glu Gly Ala 550 555 560 565 gtc gaa aag ctc cgc gaa gcg ggc gtt gag cgc atc ctg ctt gct ggc 1843 Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg Ile Leu Leu Ala Gly 570 575 580 gcg ccg aag agc ttt gag ggc agc gcg cat gcg ccc gat ggt tat ttg 1891 Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala Pro Asp Gly Tyr Leu 585 590 595 aac atg aca att gat gcc gcg gcg acg ctg gct gac ctg cta gat gct 1939 Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala Asp Leu Leu Asp Ala 600 605 610 ttg gga gct taaatcatga cgtcgatccc taatttttca 1978 Leu Gly Ala 615 <210> 2 <211> 616 <212> PRT <213> Corynebacterium glutamicum <400> 2 Leu Thr Asp Leu Thr Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn 1 5 10 15 Leu Glu Thr Trp Tyr Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln 20 25 30 Lys Lys Asp Ile Gly Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile 35 40 45 Val Thr Thr Pro Asp Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala 50 55 60 Asp Glu Ser Gln Arg Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe 65 70 75 80 Thr Arg Gly Thr Thr Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr 85 90 95 Glu Thr Phe Gly His Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu 100 105 110 Asn Ala Leu Asn Ser Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu 115 120 125 Glu Phe Thr Ala Ala Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu 130 135 140 Asn Met Ala Pro Leu Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val 145 150 155 160 Ala Ala Ala Leu Tyr Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala 165 170 175 Ala Leu Thr Leu Gly Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser 180 185 190 His Ser Asp Thr Ile Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser 195 200 205 Lys Arg Ala Asn Val Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser 210 215 220 Asn Gln Gly Ala Ser Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala 225 230 235 240 Gly Val Asp Tyr Val Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu 245 250 255 Ala Ala Leu Lys Gln Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln 260 265 270 Phe Ala Gln Ile Ser Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg 275 280 285 Val Cys Glu Val Leu Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His 290 295 300 Ala Val Thr Ala Arg Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn 305 310 315 320 Met Leu Arg Ser Thr Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala 325 330 335 Thr Asp Val Glu Val Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val 340 345 350 Pro Gly Val Ser Arg Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn 355 360 365 Leu Leu Leu Leu Glu Glu Ser His Leu Gly His Val Val Asp Pro Ala 370 375 380 Gly Gly Ser Tyr Phe Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys 385 390 395 400 Ala Trp Ala Val Phe Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala 405 410 415 Ala Cys Ala Ser Gly Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu 420 425 430 Gln Thr Arg Ala Asp Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile 435 440 445 Asn Glu Phe Pro Asn Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg 450 455 460 Val Glu Pro Ala Gly Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu 465 470 475 480 Arg Asn Arg Ser Asp Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln 485 490 495 Ile Thr Met Ile Pro Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr 500 505 510 Gly Phe Thr Ser Asn Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn 515 520 525 Pro Gly Gln Leu Val Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln 530 535 540 Ala Ala Gly Ile Val Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu 545 550 555 560 Thr Gly Glu Gly Ala Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg 565 570 575 Ile Leu Leu Ala Gly Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala 580 585 590 Pro Asp Gly Tyr Leu Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala 595 600 605 Asp Leu Leu Asp Ala Leu Gly Ala 610 615 <210> 3 <211> 904 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(874) <223> RXA00186 <400> 3 cggagcattt cccatgagtc ttcatccaga agcccagcat tttgtttagc tcacctctaa 60 agctcctgat ctggatacga ggactcctgc ggaaaaccgt gtg gct agt gaa gct 115 Val Ala Ser Glu Ala 1 5 acc cgg cat ctc atg ggg gag aag act tct gtc gcg tat gtt cac gat 163 Thr Arg His Leu Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp 10 15 20 gtt ctg atc aag ggc gtg cca gtg cgg ata tac aat ccg cac ccc aac 211 Val Leu Ile Lys Gly Val Pro Val Arg Ile Tyr Asn Pro His Pro Asn 25 30 35 gac ggg ccg ctt cct gtc ttt atc tac ttc cat ggt ggc gga tgg gtt 259 Asp Gly Pro Leu Pro Val Phe Ile Tyr Phe His Gly Gly Gly Trp Val 40 45 50 ttg ggg gac ctt gaa tca gtg gat tcc acc gtg cgc gat att gcc gtt 307 Leu Gly Asp Leu Glu Ser Val Asp Ser Thr Val Arg Asp Ile Ala Val 55 60 65 gct tca ggc gcc ctg tgt atc agt gtg gat tat cgc cgt gca ccg gaa 355 Ala Ser Gly Ala Leu Cys Ile Ser Val Asp Tyr Arg Arg Ala Pro Glu 70 75 80 85 cat cct ttt ctc gct gca ttg gat gat tgc caa gtg gtc acg gaa gct 403 His Pro Phe Leu Ala Ala Leu Asp Asp Cys Gln Val Val Thr Glu Ala 90 95 100 gtc ctc aat ggt gaa ctc gcc agt gct aac cag cat cta gtg gca gtc 451 Val Leu Asn Gly Glu Leu Ala Ser Ala Asn Gln His Leu Val Ala Val 105 110 115 ggc ggg gac agc gcc ggt ggc aat att gcg gcg gtc atc gct caa cag 499 Gly Gly Asp Ser Ala Gly Gly Asn Ile Ala Ala Val Ile Ala Gln Gln 120 125 130 ctg cgc gat cag atc acc cac caa gtt ctt gtg tat ccg gtg atg gac 547 Leu Arg Asp Gln Ile Thr His Gln Val Leu Val Tyr Pro Val Met Asp 135 140 145 gta atc ttg ctg gtg att tgt tct atc att acc act ggt ttt gcg ctg 595 Val Ile Leu Leu Val Ile Cys Ser Ile Ile Thr Thr Gly Phe Ala Leu 150 155 160 165 ctc atg cat cca aag agc aag gac aag acg gag acg att tct gat gaa 643 Leu Met His Pro Lys Ser Lys Asp Lys Thr Glu Thr Ile Ser Asp Glu 170 175 180 ttc ctc gca gag atc caa gcg gga agt gaa aag atc tcc att ctg cgt 691 Phe Leu Ala Glu Ile Gln Ala Gly Ser Glu Lys Ile Ser Ile Leu Arg 185 190 195 tcg acc cct gct gaa aaa gcc aat gcg agc cgc tgg atc atg tac ttc 739 Ser Thr Pro Ala Glu Lys Ala Asn Ala Ser Arg Trp Ile Met Tyr Phe 200 205 210 gtt ggc gga att ggc ctg ctc tac agc gtg ttc agc ctg tgg aca ggt 787 Val Gly Gly Ile Gly Leu Leu Tyr Ser Val Phe Ser Leu Trp Thr Gly 215 220 225 ggc gta acc gga ctg acg ttg aac tcc ttc aac ttc ctg ttc ctg tca 835 Gly Val Thr Gly Leu Thr Leu Asn Ser Phe Asn Phe Leu Phe Leu Ser 230 235 240 245 ctc ggc atg gtg ctc acc gct aat tac ggg cca gag tat taagcaaagc 884 Leu Gly Met Val Leu Thr Ala Asn Tyr Gly Pro Glu Tyr 250 255 ttattcgcga aggcatccaa 904 <210> 4 <211> 258 <212> PRT <213> Corynebacterium glutamicum <400> 4 Val Ala Ser Glu Ala Thr Arg His Leu Met Gly Glu Lys Thr Ser Val 1 5 10 15 Ala Tyr Val His Asp Val Leu Ile Lys Gly Val Pro Val Arg Ile Tyr 20 25 30 Asn Pro His Pro Asn Asp Gly Pro Leu Pro Val Phe Ile Tyr Phe His 35 40 45 Gly Gly Gly Trp Val Leu Gly Asp Leu Glu Ser Val Asp Ser Thr Val 50 55 60 Arg Asp Ile Ala Val Ala Ser Gly Ala Leu Cys Ile Ser Val Asp Tyr 65 70 75 80 Arg Arg Ala Pro Glu His Pro Phe Leu Ala Ala Leu Asp Asp Cys Gln 85 90 95 Val Val Thr Glu Ala Val Leu Asn Gly Glu Leu Ala Ser Ala Asn Gln 100 105 110 His Leu Val Ala Val Gly Gly Asp Ser Ala Gly Gly Asn Ile Ala Ala 115 120 125 Val Ile Ala Gln Gln Leu Arg Asp Gln Ile Thr His Gln Val Leu Val 130 135 140 Tyr Pro Val Met Asp Val Ile Leu Leu Val Ile Cys Ser Ile Ile Thr 145 150 155 160 Thr Gly Phe Ala Leu Leu Met His Pro Lys Ser Lys Asp Lys Thr Glu 165 170 175 Thr Ile Ser Asp Glu Phe Leu Ala Glu Ile Gln Ala Gly Ser Glu Lys 180 185 190 Ile Ser Ile Leu Arg Ser Thr Pro Ala Glu Lys Ala Asn Ala Ser Arg 195 200 205 Trp Ile Met Tyr Phe Val Gly Gly Ile Gly Leu Leu Tyr Ser Val Phe 210 215 220 Ser Leu Trp Thr Gly Gly Val Thr Gly Leu Thr Leu Asn Ser Phe Asn 225 230 235 240 Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Ala Asn Tyr Gly Pro 245 250 255 Glu Tyr <210> 5 <211> 1102 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1072) <223> RXA00203 <400> 5 gaacaaccca ggacgatgtc atggctctag ctgtttccca ggtggatgat tccatcaccg 60 aggaagctgc tgcagaaatc gaaaacacaa aggaggaccg ttg agc acc gcc gta 115 Leu Ser Thr Ala Val 1 5 gtt tca cag aag aag tcc aca acg gca tcc aaa att gga cat tgg atg 163 Val Ser Gln Lys Lys Ser Thr Thr Ala Ser Lys Ile Gly His Trp Met 10 15 20 ctc aat aac ggt gcg ttg gtg ggg ctg att gca ctg tgt gtt gga ctt 211 Leu Asn Asn Gly Ala Leu Val Gly Leu Ile Ala Leu Cys Val Gly Leu 25 30 35 ttt att gca aca ccc cac ttt ctc acc att cct aac ctg atc aac atc 259 Phe Ile Ala Thr Pro His Phe Leu Thr Ile Pro Asn Leu Ile Asn Ile 40 45 50 ggt atc caa tcg gcg acg gtg gcg atc ctg gcg ttc ggc atg acc ttc 307 Gly Ile Gln Ser Ala Thr Val Ala Ile Leu Ala Phe Gly Met Thr Phe 55 60 65 gtc atc gtt acc gca ggc att gat ttg tct gtg gga tca gtg gct gcg 355 Val Ile Val Thr Ala Gly Ile Asp Leu Ser Val Gly Ser Val Ala Ala 70 75 80 85 ttg ggt gcg atg acc tcg gcg tat ttc ttc gcg gaa gtt ggt ttg ccg 403 Leu Gly Ala Met Thr Ser Ala Tyr Phe Phe Ala Glu Val Gly Leu Pro 90 95 100 ggc tgg atc acg ctg ctg att ggc ctg ttc atc gga ttg ttg gcg ggt 451 Gly Trp Ile Thr Leu Leu Ile Gly Leu Phe Ile Gly Leu Leu Ala Gly 105 110 115 gcg atc tct ggc att tct att gct tat ggc aag ttg cct gcg ttt att 499 Ala Ile Ser Gly Ile Ser Ile Ala Tyr Gly Lys Leu Pro Ala Phe Ile 120 125 130 gcc acc ttg gcc atg atg tcg atc gcc agg gga atc acc ttg gtc att 547 Ala Thr Leu Ala Met Met Ser Ile Ala Arg Gly Ile Thr Leu Val Ile 135 140 145 tcc caa ggc tca cca att ccc agt gca cca gct gtg aac gct ttg ggg 595 Ser Gln Gly Ser Pro Ile Pro Ser Ala Pro Ala Val Asn Ala Leu Gly 150 155 160 165 cgc acc tac ttt ggc atc ccg atg ccg att ctg atg atg gca ctg gct 643 Arg Thr Tyr Phe Gly Ile Pro Met Pro Ile Leu Met Met Ala Leu Ala 170 175 180 ggc att gtg tgt tgg ttt att ttg agc cgc acc gtg ctg gga cgg tcc 691 Gly Ile Val Cys Trp Phe Ile Leu Ser Arg Thr Val Leu Gly Arg Ser 185 190 195 atg tac gcc att ggc gga aac atg gaa gca gcc cga cta tct ggt ctg 739 Met Tyr Ala Ile Gly Gly Asn Met Glu Ala Ala Arg Leu Ser Gly Leu 200 205 210 cca gtg aag aaa atc ctg gtc atg gtc tat gca ctg gct ggt gtg tat 787 Pro Val Lys Lys Ile Leu Val Met Val Tyr Ala Leu Ala Gly Val Tyr 215 220 225 gca gca ctt gcg ggt ctg gtc atg acg gga cgc ttg tcg tcc gcg cag 835 Ala Ala Leu Ala Gly Leu Val Met Thr Gly Arg Leu Ser Ser Ala Gln 230 235 240 245 ccg cag gca ggc gtg gga tac gaa ctc gat gcg att gcc gcc gtg gtc 883 Pro Gln Ala Gly Val Gly Tyr Glu Leu Asp Ala Ile Ala Ala Val Val 250 255 260 att ggt ggt gcg tca ctt gct ggc gga acc gga aaa gca acg ggc act 931 Ile Gly Gly Ala Ser Leu Ala Gly Gly Thr Gly Lys Ala Thr Gly Thr 265 270 275 ttg att ggt gcc atc ttg ttg gcc gtg atc cgc aat ggc ttg aac att 979 Leu Ile Gly Ala Ile Leu Leu Ala Val Ile Arg Asn Gly Leu Asn Ile 280 285 290 ttg aac gtg tcc tcg ttc tgg cag cag att gtc atc ggt tgt gtc atc 1027 Leu Asn Val Ser Ser Phe Trp Gln Gln Ile Val Ile Gly Cys Val Ile 295 300 305 gcg ctt gcg gtg ggc ttc gat gtc atc cga aac aaa acc tct aag 1072 Ala Leu Ala Val Gly Phe Asp Val Ile Arg Asn Lys Thr Ser Lys 310 315 320 taattcctga aaggaaattt tcacatgtac 1102 <210> 6 <211> 324 <212> PRT <213> Corynebacterium glutamicum <400> 6 Leu Ser Thr Ala Val Val Ser Gln Lys Lys Ser Thr Thr Ala Ser Lys 1 5 10 15 Ile Gly His Trp Met Leu Asn Asn Gly Ala Leu Val Gly Leu Ile Ala 20 25 30 Leu Cys Val Gly Leu Phe Ile Ala Thr Pro His Phe Leu Thr Ile Pro 35 40 45 Asn Leu Ile Asn Ile Gly Ile Gln Ser Ala Thr Val Ala Ile Leu Ala 50 55 60 Phe Gly Met Thr Phe Val Ile Val Thr Ala Gly Ile Asp Leu Ser Val 65 70 75 80 Gly Ser Val Ala Ala Leu Gly Ala Met Thr Ser Ala Tyr Phe Phe Ala 85 90 95 Glu Val Gly Leu Pro Gly Trp Ile Thr Leu Leu Ile Gly Leu Phe Ile 100 105 110 Gly Leu Leu Ala Gly Ala Ile Ser Gly Ile Ser Ile Ala Tyr Gly Lys 115 120 125 Leu Pro Ala Phe Ile Ala Thr Leu Ala Met Met Ser Ile Ala Arg Gly 130 135 140 Ile Thr Leu Val Ile Ser Gln Gly Ser Pro Ile Pro Ser Ala Pro Ala 145 150 155 160 Val Asn Ala Leu Gly Arg Thr Tyr Phe Gly Ile Pro Met Pro Ile Leu 165 170 175 Met Met Ala Leu Ala Gly Ile Val Cys Trp Phe Ile Leu Ser Arg Thr 180 185 190 Val Leu Gly Arg Ser Met Tyr Ala Ile Gly Gly Asn Met Glu Ala Ala 195 200 205 Arg Leu Ser Gly Leu Pro Val Lys Lys Ile Leu Val Met Val Tyr Ala 210 215 220 Leu Ala Gly Val Tyr Ala Ala Leu Ala Gly Leu Val Met Thr Gly Arg 225 230 235 240 Leu Ser Ser Ala Gln Pro Gln Ala Gly Val Gly Tyr Glu Leu Asp Ala 245 250 255 Ile Ala Ala Val Val Ile Gly Gly Ala Ser Leu Ala Gly Gly Thr Gly 260 265 270 Lys Ala Thr Gly Thr Leu Ile Gly Ala Ile Leu Leu Ala Val Ile Arg 275 280 285 Asn Gly Leu Asn Ile Leu Asn Val Ser Ser Phe Trp Gln Gln Ile Val 290 295 300 Ile Gly Cys Val Ile Ala Leu Ala Val Gly Phe Asp Val Ile Arg Asn 305 310 315 320 Lys Thr Ser Lys <210> 7 <211> 1009 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(979) <223> RXA00228 <400> 7 atcaagcaga cacatcggca attagccggg ggtatgtctc cattatgaaa gcttaacgga 60 gctgtgtcac ttccacacgg aaccggagaa atcagtcaag atg gga gat gtg act 115 Met Gly Asp Val Thr 1 5 aac tct ata aat aac tct gca gct gca tct ttt ccc tct gat gaa gaa 163 Asn Ser Ile Asn Asn Ser Ala Ala Ala Ser Phe Pro Ser Asp Glu Glu 10 15 20 gaa tcc aat gaa gac ctc ctc atc gat ttc caa gga gtc ttc ttt aag 211 Glu Ser Asn Glu Asp Leu Leu Ile Asp Phe Gln Gly Val Phe Phe Lys 25 30 35 agg gat ggt cga aac ctc gtc ggc ccc gtc gac tgg caa gta gaa cta 259 Arg Asp Gly Arg Asn Leu Val Gly Pro Val Asp Trp Gln Val Glu Leu 40 45 50 gat gaa cgc tgg gta att atc gga cca aac gga gcc ggc aaa acc aca 307 Asp Glu Arg Trp Val Ile Ile Gly Pro Asn Gly Ala Gly Lys Thr Thr 55 60 65 ctc atc cgc atg gca tcc gcc gaa gaa ttc ccc tcc gga gga atg gca 355 Leu Ile Arg Met Ala Ser Ala Glu Glu Phe Pro Ser Gly Gly Met Ala 70 75 80 85 cgc ctc atg gga gaa cgc atc ggc aaa act gac atg cgc gac ctc cgc 403 Arg Leu Met Gly Glu Arg Ile Gly Lys Thr Asp Met Arg Asp Leu Arg 90 95 100 tcc atg atc ggc gtc agc tcc tcc gca tta ggc aac cga atc ccc tcc 451 Ser Met Ile Gly Val Ser Ser Ser Ala Leu Gly Asn Arg Ile Pro Ser 105 110 115 gaa gaa aaa gtc tct gac cta gtc atc tcc gca ggc tac gca atc ctc 499 Glu Glu Lys Val Ser Asp Leu Val Ile Ser Ala Gly Tyr Ala Ile Leu 120 125 130 ggc cgc tgg cgc gaa gac tac gac gaa atg gac ttc gga caa gcc acc 547 Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp Phe Gly Gln Ala Thr 135 140 145 gaa atc ctc gaa caa gtc gga gcc atg cac cta gcc gac cgc acc tgg 595 Glu Ile Leu Glu Gln Val Gly Ala Met His Leu Ala Asp Arg Thr Trp 150 155 160 165 gga acc ctc tcc gaa ggc gaa cgc aaa cga gtc ctg gtc gca cgc gca 643 Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val Leu Val Ala Arg Ala 170 175 180 ctc atg acc aac ccg gaa ctc ctc atc ctt gac gaa cca acc gca gga 691 Leu Met Thr Asn Pro Glu Leu Leu Ile Leu Asp Glu Pro Thr Ala Gly 185 190 195 atg gac ctc ggc gga cgc gaa gac ctc gtc ggc tac ctc gga gaa ctc 739 Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly Tyr Leu Gly Glu Leu 200 205 210 gcc atg gac cca gac gca cct gcc atc gtc atg atc acc cac cac gtc 787 Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met Ile Thr His His Val 215 220 225 gaa gaa atc ccc gcc gga ttc acc cac gca atg ctc ctc gac gaa ggt 835 Glu Glu Ile Pro Ala Gly Phe Thr His Ala Met Leu Leu Asp Glu Gly 230 235 240 245 gaa atc gta gcc caa ggc ctg atc aac acc gtc atg aca aac gag aac 883 Glu Ile Val Ala Gln Gly Leu Ile Asn Thr Val Met Thr Asn Glu Asn 250 255 260 cta tcc aaa gca ttc cac cag cca atc caa gta gac cgc atc ggg gaa 931 Leu Ser Lys Ala Phe His Gln Pro Ile Gln Val Asp Arg Ile Gly Glu 265 270 275 cgc tac ttt gcc cgc cgt gtg aga acc gcc agg agt cat agg gct cag 979 Arg Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg Ser His Arg Ala Gln 280 285 290 taggtttttt ggagttgtgg gccggtgttg 1009 <210> 8 <211> 293 <212> PRT <213> Corynebacterium glutamicum <400> 8 Met Gly Asp Val Thr Asn Ser Ile Asn Asn Ser Ala Ala Ala Ser Phe 1 5 10 15 Pro Ser Asp Glu Glu Glu Ser Asn Glu Asp Leu Leu Ile Asp Phe Gln 20 25 30 Gly Val Phe Phe Lys Arg Asp Gly Arg Asn Leu Val Gly Pro Val Asp 35 40 45 Trp Gln Val Glu Leu Asp Glu Arg Trp Val Ile Ile Gly Pro Asn Gly 50 55 60 Ala Gly Lys Thr Thr Leu Ile Arg Met Ala Ser Ala Glu Glu Phe Pro 65 70 75 80 Ser Gly Gly Met Ala Arg Leu Met Gly Glu Arg Ile Gly Lys Thr Asp 85 90 95 Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser Ser Ser Ala Leu Gly 100 105 110 Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp Leu Val Ile Ser Ala 115 120 125 Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp 130 135 140 Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val Gly Ala Met His Leu 145 150 155 160 Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val 165 170 175 Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu Leu Leu Ile Leu Asp 180 185 190 Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly 195 200 205 Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met 210 215 220 Ile Thr His His Val Glu Glu Ile Pro Ala Gly Phe Thr His Ala Met 225 230 235 240 Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly Leu Ile Asn Thr Val 245 250 255 Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His Gln Pro Ile Gln Val 260 265 270 Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg 275 280 285 Ser His Arg Ala Gln 290 <210> 9 <211> 1975 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1945) <223> RXA00298 <400> 9 tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60 tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115 Met Ser Ser Asn Ile 1 5 gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163 Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser 10 15 20 gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211 Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val 25 30 35 atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259 Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala 40 45 50 att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307 Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly 55 60 65 gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355 Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr 70 75 80 85 ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403 Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu 90 95 100 atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451 Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu 105 110 115 atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499 Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro 120 125 130 atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547 Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe 135 140 145 gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595 Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala 150 155 160 165 ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643 Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro 170 175 180 ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691 Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr 185 190 195 tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739 Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr 200 205 210 ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787 Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala 215 220 225 ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835 Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu 230 235 240 245 ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883 Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser 250 255 260 ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931 Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met 265 270 275 gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979 Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr 280 285 290 ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027 Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met 295 300 305 cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075 Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp 310 315 320 325 cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123 Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser 330 335 340 cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171 Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val 345 350 355 cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219 Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val 360 365 370 gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267 Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser 375 380 385 aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315 Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro 390 395 400 405 gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363 Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val 410 415 420 tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411 Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile 425 430 435 gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459 Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn 440 445 450 caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507 Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala 455 460 465 gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555 Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr 470 475 480 485 ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603 Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln 490 495 500 ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651 Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala 505 510 515 gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699 Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro 520 525 530 gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747 Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp 535 540 545 gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795 Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly 550 555 560 565 aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843 Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val 570 575 580 gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891 Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser 585 590 595 cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939 Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr 600 605 610 gat att taaacgattg cttttcgacg cacctcccac 1975 Asp Ile 615 <210> 10 <211> 615 <212> PRT <213> Corynebacterium glutamicum <400> 10 Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys 1 5 10 15 Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe 20 25 30 Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg 35 40 45 Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp 50 55 60 Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile 65 70 75 80 Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp 85 90 95 Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly 100 105 110 Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His 115 120 125 Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala 130 135 140 Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met 145 150 155 160 Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr 165 170 175 Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu 180 185 190 Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala 195 200 205 Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val 210 215 220 Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val 225 230 235 240 Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys 245 250 255 Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn 260 265 270 Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr 275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile 290 295 300 Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln 305 310 315 320 Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp 325 330 335 Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser 340 345 350 Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro 355 360 365 Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile 370 375 380 Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val 385 390 395 400 Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro 405 410 415 Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe 420 425 430 Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala 435 440 445 Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala 450 455 460 Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser 465 470 475 480 Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro 485 490 495 Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met 500 505 510 Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu 515 520 525 Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala 530 535 540 Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu 545 550 555 560 His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu 565 570 575 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala 580 585 590 Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln 595 600 605 Ser Arg Asp Glu Tyr Asp Ile 610 615 <210> 11 <211> 1081 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1051) <223> RXA00345 <400> 11 ttcaatctac cagttacccc tatggcgtat ccgaggtcta acgcgatttt gcgattttca 60 ataagttttc atgttgacat cctttttcaa taagcattta atg gca ggt atg aaa 115 Met Ala Gly Met Lys 1 5 aag ctt ctt tgg aca ctc ccc atc ctc cca ctg gta cta gct ggc tgc 163 Lys Leu Leu Trp Thr Leu Pro Ile Leu Pro Leu Val Leu Ala Gly Cys 10 15 20 tca act gga tca gca gat tcc gcg gat tcc acc aac gct gcc gga tcc 211 Ser Thr Gly Ser Ala Asp Ser Ala Asp Ser Thr Asn Ala Ala Gly Ser 25 30 35 aat tcc ctt aaa gtg gtc acc tcc acc cag gtg tgg gct gac gtc gcc 259 Asn Ser Leu Lys Val Val Thr Ser Thr Gln Val Trp Ala Asp Val Ala 40 45 50 gaa gct gtc gcc cca gat gta gac att gaa gca att att acc ggt ggc 307 Glu Ala Val Ala Pro Asp Val Asp Ile Glu Ala Ile Ile Thr Gly Gly 55 60 65 gac atc gac cct cat tcc ttc gag cct tcc gct acc gat atg gct aaa 355 Asp Ile Asp Pro His Ser Phe Glu Pro Ser Ala Thr Asp Met Ala Lys 70 75 80 85 gtt tcc gaa gct gac atc att atc gtc ggt ggc ggc ggc tat gat tcc 403 Val Ser Glu Ala Asp Ile Ile Ile Val Gly Gly Gly Gly Tyr Asp Ser 90 95 100 tgg ctc tac ggc acc ttg gaa gac gat gat cgc atc atc cac gca ttg 451 Trp Leu Tyr Gly Thr Leu Glu Asp Asp Asp Arg Ile Ile His Ala Leu 105 110 115 gat ctc tca gag cat gac cac agc gag cat gat gat cac gag cac gaa 499 Asp Leu Ser Glu His Asp His Ser Glu His Asp Asp His Glu His Glu 120 125 130 gcc gaa gaa gcc cac gaa cac gac cac gat gaa gag ggc cac gat cat 547 Ala Glu Glu Ala His Glu His Asp His Asp Glu Glu Gly His Asp His 135 140 145 gac gtc gac aac gag cac gtc tgg tac tcc act gaa tac gtc tct gag 595 Asp Val Asp Asn Glu His Val Trp Tyr Ser Thr Glu Tyr Val Ser Glu 150 155 160 165 gta gct gaa gag ttc gca gaa aaa gtc acc gag ctt gat ccc gag gca 643 Val Ala Glu Glu Phe Ala Glu Lys Val Thr Glu Leu Asp Pro Glu Ala 170 175 180 cag gcc gat gca acg gct gtg acc acc aag atg gac gag ctg cac aat 691 Gln Ala Asp Ala Thr Ala Val Thr Thr Lys Met Asp Glu Leu His Asn 185 190 195 cag att cac gat ctt cca gca gtt cgc att gct cag acc gag ccg atc 739 Gln Ile His Asp Leu Pro Ala Val Arg Ile Ala Gln Thr Glu Pro Ile 200 205 210 gcc gat cac att ttg tcc cac tcc gac atg gtg gaa tcc acc cct gag 787 Ala Asp His Ile Leu Ser His Ser Asp Met Val Glu Ser Thr Pro Glu 215 220 225 ggt tac cgc gca acc acg ttg agc gag agc gag cca acc gca gca gat 835 Gly Tyr Arg Ala Thr Thr Leu Ser Glu Ser Glu Pro Thr Ala Ala Asp 230 235 240 245 gtt gcg tcg ttc cag gat gca att aac aac ggt gac ctc gat gtt ttg 883 Val Ala Ser Phe Gln Asp Ala Ile Asn Asn Gly Asp Leu Asp Val Leu 250 255 260 atc tac aac cca cag tcc gcg tcg act gtc gcg acc agc ttg aag gat 931 Ile Tyr Asn Pro Gln Ser Ala Ser Thr Val Ala Thr Ser Leu Lys Asp 265 270 275 ttg gca gaa gaa aaa ggc atc cca gtt gtt gag atc tat gag acc cct 979 Leu Ala Glu Glu Lys Gly Ile Pro Val Val Glu Ile Tyr Glu Thr Pro 280 285 290 caa aac acc gag aat ttc ctc gat gca ttc acc aag gca gtt gat gat 1027 Gln Asn Thr Glu Asn Phe Leu Asp Ala Phe Thr Lys Ala Val Asp Asp 295 300 305 ctc acc gct gcc act aac cag gtt tagaattatt taaatgctgt tgactttcaa 1081 Leu Thr Ala Ala Thr Asn Gln Val 310 315 <210> 12 <211> 317 <212> PRT <213> Corynebacterium glutamicum <400> 12 Met Ala Gly Met Lys Lys Leu Leu Trp Thr Leu Pro Ile Leu Pro Leu 1 5 10 15 Val Leu Ala Gly Cys Ser Thr Gly Ser Ala Asp Ser Ala Asp Ser Thr 20 25 30 Asn Ala Ala Gly Ser Asn Ser Leu Lys Val Val Thr Ser Thr Gln Val 35 40 45 Trp Ala Asp Val Ala Glu Ala Val Ala Pro Asp Val Asp Ile Glu Ala 50 55 60 Ile Ile Thr Gly Gly Asp Ile Asp Pro His Ser Phe Glu Pro Ser Ala 65 70 75 80 Thr Asp Met Ala Lys Val Ser Glu Ala Asp Ile Ile Ile Val Gly Gly 85 90 95 Gly Gly Tyr Asp Ser Trp Leu Tyr Gly Thr Leu Glu Asp Asp Asp Arg 100 105 110 Ile Ile His Ala Leu Asp Leu Ser Glu His Asp His Ser Glu His Asp 115 120 125 Asp His Glu His Glu Ala Glu Glu Ala His Glu His Asp His Asp Glu 130 135 140 Glu Gly His Asp His Asp Val Asp Asn Glu His Val Trp Tyr Ser Thr 145 150 155 160 Glu Tyr Val Ser Glu Val Ala Glu Glu Phe Ala Glu Lys Val Thr Glu 165 170 175 Leu Asp Pro Glu Ala Gln Ala Asp Ala Thr Ala Val Thr Thr Lys Met 180 185 190 Asp Glu Leu His Asn Gln Ile His Asp Leu Pro Ala Val Arg Ile Ala 195 200 205 Gln Thr Glu Pro Ile Ala Asp His Ile Leu Ser His Ser Asp Met Val 210 215 220 Glu Ser Thr Pro Glu Gly Tyr Arg Ala Thr Thr Leu Ser Glu Ser Glu 225 230 235 240 Pro Thr Ala Ala Asp Val Ala Ser Phe Gln Asp Ala Ile Asn Asn Gly 245 250 255 Asp Leu Asp Val Leu Ile Tyr Asn Pro Gln Ser Ala Ser Thr Val Ala 260 265 270 Thr Ser Leu Lys Asp Leu Ala Glu Glu Lys Gly Ile Pro Val Val Glu 275 280 285 Ile Tyr Glu Thr Pro Gln Asn Thr Glu Asn Phe Leu Asp Ala Phe Thr 290 295 300 Lys Ala Val Asp Asp Leu Thr Ala Ala Thr Asn Gln Val 305 310 315 <210> 13 <211> 943 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(913) <223> RXA00354 <400> 13 ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60 ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115 Met Gly Lys Leu Leu 1 5 ttc gta gac atc ggt ggc aca ctg ctg gat tac tca aat gaa gtt ccg 163 Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro 10 15 20 cgt tcg gcc gtt gac gcg atc cgt aag gca cgc gcc aaa gga cac cgc 211 Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg 25 30 35 gtg tac ttg agc tct ggt cga agc agc gct gag gtg act tct cag ttg 259 Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu Val Thr Ser Gln Leu 40 45 50 tgg gat atc gga gtg gat ggc ctc att ggc gca aat ggt gga tat gtg 307 Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala Asn Gly Gly Tyr Val 55 60 65 gaa agc gca cag gag tct gtg ttc cac cgc cgt ttg tcg ggt gag gag 355 Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu 70 75 80 85 acc cgc cac att gtg gag tgg ctc tac aac cgt ggt ttg gag ttt tat 403 Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr 90 95 100 ctc gag tcc aac aac ggt ttg tat gca agc cgt ggt ttc cgt gag gct 451 Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala 105 110 115 tct aag cca gtg ctg tct cgc ctt tcg gag aag acc gac gtg aca gtc 499 Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val 120 125 130 gat agc atg tac ccg gat atg ttc tgg ggc gcg agc ctt gat cgt gac 547 Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp 135 140 145 gat gtg aac aag atc agt tac atc ttc aat tct cag gaa gat ttg gac 595 Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser Gln Glu Asp Leu Asp 150 155 160 165 gca gcg cgt gag gcg ttc cct aac ctg gag cac acc acg tgg ggt ggt 643 Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly 170 175 180 cag acg ggt gcg ttg ttc ggc acg atc ggt gtg tct gtc aac aag aag 691 Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val Ser Val Asn Lys Lys 185 190 195 atc ggc gtg gat cgc ctg ctg aag tac ctg aac gca gat cgc gca aac 739 Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Ala Asp Arg Ala Asn 200 205 210 acc att gcg ttc ggc gac agc gat gag gat ctc tcc cta ttt gag gcg 787 Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Ala 215 220 225 agc gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg ctc aag gct 835 Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr Glu Ser Leu Lys Ala 230 235 240 245 gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883 Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln Asp Gly Leu Arg Asn 250 255 260 gcg ttt tta aag ctt gag ctt atc gac gcc tgaccccatc aaagaacttc 933 Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala 265 270 ccaatctcct 943 <210> 14 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 14 Met Gly Lys Leu Leu Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr 1 5 10 15 Ser Asn Glu Val Pro Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg 20 25 30 Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu 35 40 45 Val Thr Ser Gln Leu Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala 50 55 60 Asn Gly Gly Tyr Val Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg 65 70 75 80 Leu Ser Gly Glu Glu Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg 85 90 95 Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg 100 105 110 Gly Phe Arg Glu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys 115 120 125 Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala 130 135 140 Ser Leu Asp Arg Asp Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser 145 150 155 160 Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His 165 170 175 Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val 180 185 190 Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn 195 200 205 Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu 210 215 220 Ser Leu Phe Glu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr 225 230 235 240 Glu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln 245 250 255 Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala 260 265 270 <210> 15 <211> 1774 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1744) <223> RXA00368 <400> 15 ttggctgaca tcgagctcat gacccctgac ctggaggttg taaccgctga taaggcggct 60 gctgttgagt tcttccaaaa cgcaatgaac tagttttcct atg cag tta tct cct 115 Met Gln Leu Ser Pro 1 5 tca aat acg tcg acg cag cgc ttt cac atc tct gcg ttg acg tct ttg 163 Ser Asn Thr Ser Thr Gln Arg Phe His Ile Ser Ala Leu Thr Ser Leu 10 15 20 tct ttc atg cgt ctg ggt gtg tgg ctg att gtc gcg ggg ttg ttt atc 211 Ser Phe Met Arg Leu Gly Val Trp Leu Ile Val Ala Gly Leu Phe Ile 25 30 35 act ccg ttg gcg ctg gtg gtg ggc ttg gcg ttg gga ggc aat cag ttt 259 Thr Pro Leu Ala Leu Val Val Gly Leu Ala Leu Gly Gly Asn Gln Phe 40 45 50 cct gct ctg tgg gat tcc gga ttg ggc aaa gcc cta tgg aat tcc gcc 307 Pro Ala Leu Trp Asp Ser Gly Leu Gly Lys Ala Leu Trp Asn Ser Ala 55 60 65 tat aca aca gtg ctt tct gcg gtg ggc gcg acc att atc ggc acg atc 355 Tyr Thr Thr Val Leu Ser Ala Val Gly Ala Thr Ile Ile Gly Thr Ile 70 75 80 85 atg gct ctc acg ctg gac cga act gat gtt ttc ggg cgc acc gcg ttg 403 Met Ala Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arg Thr Ala Leu 90 95 100 cgg tta ttt ttg tta tcc ccg ctg ttg atc cct ccg ttt att ggg gct 451 Arg Leu Phe Leu Leu Ser Pro Leu Leu Ile Pro Pro Phe Ile Gly Ala 105 110 115 att gcg tgg ttg cag ctg ttc ggg aag aac cag ggc atc aac cgg ttt 499 Ile Ala Trp Leu Gln Leu Phe Gly Lys Asn Gln Gly Ile Asn Arg Phe 120 125 130 ttc ggc acg gaa gtg tgg gat att tac ggc gct gat ggt gtg aca ttt 547 Phe Gly Thr Glu Val Trp Asp Ile Tyr Gly Ala Asp Gly Val Thr Phe 135 140 145 ttg ttg att gtg cac tcc tat ccc act gtg tac atc att gtt tcg gca 595 Leu Leu Ile Val His Ser Tyr Pro Thr Val Tyr Ile Ile Val Ser Ala 150 155 160 165 gct ctg agg caa ctt cct agt gat ttg gag caa gct gca cgg atc gcg 643 Ala Leu Arg Gln Leu Pro Ser Asp Leu Glu Gln Ala Ala Arg Ile Ala 170 175 180 ggg gcg gat act ttt acg gtg ttg cgc acc atc aca ctc cca ctg ctc 691 Gly Ala Asp Thr Phe Thr Val Leu Arg Thr Ile Thr Leu Pro Leu Leu 185 190 195 aaa cct gca ttg ttg tcg gcg ttt act ctt acc aca gtg gcg aac ctc 739 Lys Pro Ala Leu Leu Ser Ala Phe Thr Leu Thr Thr Val Ala Asn Leu 200 205 210 gcc gac ttt ggc att cca gct ctg ttg gga tcg cca gcg cgt ttt gaa 787 Ala Asp Phe Gly Ile Pro Ala Leu Leu Gly Ser Pro Ala Arg Phe Glu 215 220 225 acc tta gcc acc atg att tat cgc ttc atg gaa tcc ggc acc gtg agc 835 Thr Leu Ala Thr Met Ile Tyr Arg Phe Met Glu Ser Gly Thr Val Ser 230 235 240 245 aat cca ttg cag gtg gta tcc acc att ggc atc gtg ttg ttg ttc ctg 883 Asn Pro Leu Gln Val Val Ser Thr Ile Gly Ile Val Leu Leu Phe Leu 250 255 260 gga atc gca gca gta acc gcg gat tat ctg gtg tct ttg tac gcg gca 931 Gly Ile Ala Ala Val Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala 265 270 275 tca aag ttg caa gac gca gga aca ccg cat cgc ttt act ctc aac aaa 979 Ser Lys Leu Gln Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys 280 285 290 tca cga atc cca gtc agc gtg atc acg tgg atc atc gcg ttg atc atc 1027 Ser Arg Ile Pro Val Ser Val Ile Thr Trp Ile Ile Ala Leu Ile Ile 295 300 305 acc gcc gcc ccg ctg ctg ggt ctg gca tac aga gca tta ctg cct gcc 1075 Thr Ala Ala Pro Leu Leu Gly Leu Ala Tyr Arg Ala Leu Leu Pro Ala 310 315 320 325 cca ggt gtg ccg ttc aac cta gac aac atc acg ctc aac aac ttt gaa 1123 Pro Gly Val Pro Phe Asn Leu Asp Asn Ile Thr Leu Asn Asn Phe Glu 330 335 340 gca gca ctg agc aat cca cga gta atc gaa gga ttc agc aac tcc ctc 1171 Ala Ala Leu Ser Asn Pro Arg Val Ile Glu Gly Phe Ser Asn Ser Leu 345 350 355 atg tta tcc ctg ggt gca gcc cta atc tgt ggg gtg ctg gga tgg ctg 1219 Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly Trp Leu 360 365 370 atc gga gtg ctc atc acc cga acc cag cat ttc gcc aac gta ccg ttg 1267 Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val Pro Leu 375 380 385 aca ctc act gtg ctg ctt ccc acc gca ctg ccg ggc atg atc atc ggc 1315 Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile Ile Gly 390 395 400 405 gtc ggc tgg ctc att ttg ggc aga tac acc gga att tac aac aca cct 1363 Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn Thr Pro 410 415 420 tgg gtg att ttg ggt gca tat gtg tgt gct ttt acc gcg ctg gtt gtc 1411 Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val 425 430 435 caa gct gta cgc gga cca ctc agt caa gca ccc gaa gca atc gaa gaa 1459 Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile Glu Glu 440 445 450 gcc gca cga atc agc ggc gca ggc aga tta cga tcc atc atg gac acc 1507 Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met Asp Thr 455 460 465 acc gga gcg atg gca att ccc gca gct ttc gcc ggc gca gtg ctg gtt 1555 Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val Leu Val 470 475 480 485 gcg gta act gcg gtt cga gag tta acc gtg tcc att ttg ctc atc gcg 1603 Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu Ile Ala 490 495 500 ccg ggc acc acc acc ctg ggt gtg cag gtg ttc aat ttg cag cag gcg 1651 Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln Gln Ala 505 510 515 gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg att atc 1699 Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala Ile Ile 520 525 530 ggt atc gtg gcg ctc gcg ttg acg gtg cgc agc cag aag gag ttt 1744 Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu Phe 535 540 545 taggtgtcat cgatcaaatt gcgcgattta 1774 <210> 16 <211> 548 <212> PRT <213> Corynebacterium glutamicum <400> 16 Met Gln Leu Ser Pro Ser Asn Thr Ser Thr Gln Arg Phe His Ile Ser 1 5 10 15 Ala Leu Thr Ser Leu Ser Phe Met Arg Leu Gly Val Trp Leu Ile Val 20 25 30 Ala Gly Leu Phe Ile Thr Pro Leu Ala Leu Val Val Gly Leu Ala Leu 35 40 45 Gly Gly Asn Gln Phe Pro Ala Leu Trp Asp Ser Gly Leu Gly Lys Ala 50 55 60 Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val Gly Ala Thr 65 70 75 80 Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr Asp Val Phe 85 90 95 Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu Leu Ile Pro 100 105 110 Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly Lys Asn Gln 115 120 125 Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile Tyr Gly Ala 130 135 140 Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro Thr Val Tyr 145 150 155 160 Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp Leu Glu Gln 165 170 175 Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu Arg Thr Ile 180 185 190 Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe Thr Leu Thr 195 200 205 Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu Leu Gly Ser 210 215 220 Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg Phe Met Glu 225 230 235 240 Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr Ile Gly Ile 245 250 255 Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp Tyr Leu Val 260 265 270 Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr Pro His Arg 275 280 285 Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile Thr Trp Ile 290 295 300 Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu Ala Tyr Arg 305 310 315 320 Ala Leu Leu Pro Ala Pro Gly Val Pro Phe Asn Leu Asp Asn Ile Thr 325 330 335 Leu Asn Asn Phe Glu Ala Ala Leu Ser Asn Pro Arg Val Ile Glu Gly 340 345 350 Phe Ser Asn Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly 355 360 365 Val Leu Gly Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe 370 375 380 Ala Asn Val Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro 385 390 395 400 Gly Met Ile Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly 405 410 415 Ile Tyr Asn Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe 420 425 430 Thr Ala Leu Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro 435 440 445 Glu Ala Ile Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg 450 455 460 Ser Ile Met Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala 465 470 475 480 Gly Ala Val Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser 485 490 495 Ile Leu Leu Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe 500 505 510 Asn Leu Gln Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu 515 520 525 Met Phe Ala Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser 530 535 540 Gln Lys Glu Phe 545 <210> 17 <211> 2764 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2734) <223> RXA00378 <400> 17 tactttttcg ctaccgtgag tcttaccgtg agccttatac tgtgaggaca ttaaaagtga 60 cacctctttt tctatctttt acaacccaag aaggtttatc gtg agc aca ccg gat 115 Val Ser Thr Pro Asp 1 5 tct tcc tcg gtg gac aag gcc gta aac act gct atc tct gac gcc aaa 163 Ser Ser Ser Val Asp Lys Ala Val Asn Thr Ala Ile Ser Asp Ala Lys 10 15 20 aca gcg gcg ctc aag gca ggt gtt gga ttg aac cga gcc acc gcc tca 211 Thr Ala Ala Leu Lys Ala Gly Val Gly Leu Asn Arg Ala Thr Ala Ser 25 30 35 gaa gaa gag gaa gat tta agc tca agc att aag gtt tct ttg gcc ttt 259 Glu Glu Glu Glu Asp Leu Ser Ser Ser Ile Lys Val Ser Leu Ala Phe 40 45 50 gag ctc gag ggg tta agc aat gca cca tcg ttg atg gtg gtg gaa aaa 307 Glu Leu Glu Gly Leu Ser Asn Ala Pro Ser Leu Met Val Val Glu Lys 55 60 65 gcc cta gag aag atc ccc ggt gta tcc gcg gat ctg att tac cct tca 355 Ala Leu Glu Lys Ile Pro Gly Val Ser Ala Asp Leu Ile Tyr Pro Ser 70 75 80 85 caa act gca tgg att aca gca act gat cgg gta cat ccc gaa acc ctc 403 Gln Thr Ala Trp Ile Thr Ala Thr Asp Arg Val His Pro Glu Thr Leu 90 95 100 att gag gtg ttt gag cag ttc ggc atc aaa gca cac ctt tct aat tca 451 Ile Glu Val Phe Glu Gln Phe Gly Ile Lys Ala His Leu Ser Asn Ser 105 110 115 tcg ctg ctg cgc agg cat caa cag ctc agc gcg gaa gta aat agg gaa 499 Ser Leu Leu Arg Arg His Gln Gln Leu Ser Ala Glu Val Asn Arg Glu 120 125 130 gca cgc ctt gat cgt tac cgc tcc cga atg gat gcc aag cga atc tcg 547 Ala Arg Leu Asp Arg Tyr Arg Ser Arg Met Asp Ala Lys Arg Ile Ser 135 140 145 cct cgt gtg cga agg cat aac cga caa gaa atg gta cat gcg gta cgc 595 Pro Arg Val Arg Arg His Asn Arg Gln Glu Met Val His Ala Val Arg 150 155 160 165 gct cgt gaa agt ggt tgg att aaa cgc agg aat cac acc acc tcg cag 643 Ala Arg Glu Ser Gly Trp Ile Lys Arg Arg Asn His Thr Thr Ser Gln 170 175 180 cat gaa gac cca atg tcg ggc gat gtg ctg ttc acc gcc cgc gca ctg 691 His Glu Asp Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arg Ala Leu 185 190 195 att aca cct aag cgt ttg tgg gtg tcg ttg ccg ttt gcg ctc atc gta 739 Ile Thr Pro Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu Ile Val 200 205 210 ttg gcg tta tcg ttg aat cct tcg tgg cag ttt gat tat tgg cag tgg 787 Leu Ala Leu Ser Leu Asn Pro Ser Trp Gln Phe Asp Tyr Trp Gln Trp 215 220 225 ttg tcc gct gtg ttg gct att cct gtg gtg gtg tgg ggt gcc tgg ccg 835 Leu Ser Ala Val Leu Ala Ile Pro Val Val Val Trp Gly Ala Trp Pro 230 235 240 245 ttt cac cgc gct gca gca ggc ggt att cgt cga gga att tcc gct ctt 883 Phe His Arg Ala Ala Ala Gly Gly Ile Arg Arg Gly Ile Ser Ala Leu 250 255 260 gat gcg acc agc tca atc gct att gct gct gca tac gcg tgg tct atc 931 Asp Ala Thr Ser Ser Ile Ala Ile Ala Ala Ala Tyr Ala Trp Ser Ile 265 270 275 gcc atg ctg ttg ttt gaa acc cca gga ggt aaa tcc tgg cgg tca tat 979 Ala Met Leu Leu Phe Glu Thr Pro Gly Gly Lys Ser Trp Arg Ser Tyr 280 285 290 ccg tcc tgg ttc gct ttt gac cac ggc acg ttg acc caa aac gag att 1027 Pro Ser Trp Phe Ala Phe Asp His Gly Thr Leu Thr Gln Asn Glu Ile 295 300 305 tat ttt gat gtg gcc tgc gga atc acc gtg ttg ctt ctt gcc gga cgg 1075 Tyr Phe Asp Val Ala Cys Gly Ile Thr Val Leu Leu Leu Ala Gly Arg 310 315 320 325 ctg ctg aca agg cgt cga agc caa tcc agt ttg tta gcg gaa ctt ggt 1123 Leu Leu Thr Arg Arg Arg Ser Gln Ser Ser Leu Leu Ala Glu Leu Gly 330 335 340 cgc ctc caa atc gat cca cag cgc att gtc act gtg gtg cgt aaa cac 1171 Arg Leu Gln Ile Asp Pro Gln Arg Ile Val Thr Val Val Arg Lys His 345 350 355 cga ttg aag cgc gta gtc cag gaa ctg aac att cca gtg cag gaa gtc 1219 Arg Leu Lys Arg Val Val Gln Glu Leu Asn Ile Pro Val Gln Glu Val 360 365 370 cgt gtc aat gac gat gtg aaa gtt cca cct aat acc acg atc cct gtg 1267 Arg Val Asn Asp Asp Val Lys Val Pro Pro Asn Thr Thr Ile Pro Val 375 380 385 gat ggc act gtc atc ggt ggc ggt tcg cgg atc gca gct agc atc atc 1315 Asp Gly Thr Val Ile Gly Gly Gly Ser Arg Ile Ala Ala Ser Ile Ile 390 395 400 405 atg gga caa gac cag cgt gat gta aaa gta aat gac aaa gtt ttc gcc 1363 Met Gly Gln Asp Gln Arg Asp Val Lys Val Asn Asp Lys Val Phe Ala 410 415 420 ggc agc ctc aac ctc gaa tcc gaa atc aag gtt cgt gtt att cgc act 1411 Gly Ser Leu Asn Leu Glu Ser Glu Ile Lys Val Arg Val Ile Arg Thr 425 430 435 ggt cac cgc acc cgc atc gcc gcg gta cat agg tgg gtt aaa gaa gcg 1459 Gly His Arg Thr Arg Ile Ala Ala Val His Arg Trp Val Lys Glu Ala 440 445 450 acg ttg aag gaa aac cgc cac aat agg gca gcg atc cgt tcg gcc ggt 1507 Thr Leu Lys Glu Asn Arg His Asn Arg Ala Ala Ile Arg Ser Ala Gly 455 460 465 aac ctt gtg ccc atc acg ttc acc ctt gct gtg gtg gac ttc tgt ctg 1555 Asn Leu Val Pro Ile Thr Phe Thr Leu Ala Val Val Asp Phe Cys Leu 470 475 480 485 tgg gca ctg atc tct gga aac atc aac gct gca ttt acc act acc ttg 1603 Trp Ala Leu Ile Ser Gly Asn Ile Asn Ala Ala Phe Thr Thr Thr Leu 490 495 500 gct gtc ctt gcg tgc gtg gct ccg gtg gcc tta gcg ttg tct gct cca 1651 Ala Val Leu Ala Cys Val Ala Pro Val Ala Leu Ala Leu Ser Ala Pro 505 510 515 ctt gcc acg agg aat tcc atc gaa gct gca gca cga cac ggt att ttg 1699 Leu Ala Thr Arg Asn Ser Ile Glu Ala Ala Ala Arg His Gly Ile Leu 520 525 530 gtc cgc tct ggt gaa att ttc cga gtt ctc gat gat gtg gat act gcc 1747 Val Arg Ser Gly Glu Ile Phe Arg Val Leu Asp Asp Val Asp Thr Ala 535 540 545 gta ttt aat cgt gtg ggc aca cta acc gat ggc gaa atg aca gtg gaa 1795 Val Phe Asn Arg Val Gly Thr Leu Thr Asp Gly Glu Met Thr Val Glu 550 555 560 565 acc gtc aca gca gac aaa ggc gag gac cca gaa cta gtg ctg cgt gtc 1843 Thr Val Thr Ala Asp Lys Gly Glu Asp Pro Glu Leu Val Leu Arg Val 570 575 580 gcc ggg gcg ttg gcc atg gaa tcc cac cac gcg att tcc aaa gca ctg 1891 Ala Gly Ala Leu Ala Met Glu Ser His His Ala Ile Ser Lys Ala Leu 585 590 595 gtg aaa gca tcc cgt gaa gct cgt gat acc ggc gcc ggt ggt gaa gat 1939 Val Lys Ala Ser Arg Glu Ala Arg Asp Thr Gly Ala Gly Gly Glu Asp 600 605 610 gtc cca cac tgg att gaa gta ggc aac gtg gaa atc acc gaa gcc ggc 1987 Val Pro His Trp Ile Glu Val Gly Asn Val Glu Ile Thr Glu Ala Gly 615 620 625 tca ttc caa gca acc atc gag ctg cca ctg atc aaa cca tct ggc gaa 2035 Ser Phe Gln Ala Thr Ile Glu Leu Pro Leu Ile Lys Pro Ser Gly Glu 630 635 640 645 aaa atc atg cgc acc aca gaa gca ctc ctg tgg cga cca cga tcc atg 2083 Lys Ile Met Arg Thr Thr Glu Ala Leu Leu Trp Arg Pro Arg Ser Met 650 655 660 aca gaa gtc cgt gag cac tta agc ccc cga cta gtg gca gca gca acc 2131 Thr Glu Val Arg Glu His Leu Ser Pro Arg Leu Val Ala Ala Ala Thr 665 670 675 tca ggt ggc gca cca ctg atc gtg cga tgg aaa ggc aaa gac cgc gga 2179 Ser Gly Gly Ala Pro Leu Ile Val Arg Trp Lys Gly Lys Asp Arg Gly 680 685 690 gtt atc act cta agt gac cac gtg aga tca gat tcc tcc gat gcg att 2227 Val Ile Thr Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Ala Ile 695 700 705 att gcg att gaa gaa caa ggc atc gag acc atg atg ctt tca cgt gat 2275 Ile Ala Ile Glu Glu Gln Gly Ile Glu Thr Met Met Leu Ser Arg Asp 710 715 720 725 act tac ccg gtg gca cgt cga tac gca gac agc tta ggc atc acc cac 2323 Thr Tyr Pro Val Ala Arg Arg Tyr Ala Asp Ser Leu Gly Ile Thr His 730 735 740 gtc ttg gcc ggc atc gcg ccg ggc aag aaa gcc cag gtc gtc cgt gca 2371 Val Leu Ala Gly Ile Ala Pro Gly Lys Lys Ala Gln Val Val Arg Ala 745 750 755 gtc cac acc cgc gga tcc act gtc gcg atg atc ggc gat gaa tca gta 2419 Val His Thr Arg Gly Ser Thr Val Ala Met Ile Gly Asp Glu Ser Val 760 765 770 atg gac tgt ttg aaa gtc gct gac gtg ggt gta ctg atg ggc gtc gat 2467 Met Asp Cys Leu Lys Val Ala Asp Val Gly Val Leu Met Gly Val Asp 775 780 785 cgt ccc tca gat ctg cgt gat gat tcc gat gac ccg gca gct gac gtt 2515 Arg Pro Ser Asp Leu Arg Asp Asp Ser Asp Asp Pro Ala Ala Asp Val 790 795 800 805 gtg gtc atg cgc gaa gag gtc atg agc gtg ccg acg ctg ttt aaa ctg 2563 Val Val Met Arg Glu Glu Val Met Ser Val Pro Thr Leu Phe Lys Leu 810 815 820 gct cga cgc tac gcc aag ttg gtc aat ggc aat att gct ctg gcc tgg 2611 Ala Arg Arg Tyr Ala Lys Leu Val Asn Gly Asn Ile Ala Leu Ala Trp 825 830 835 atc tat aac ggt gtt gcc atg gtg ctt gca gtg tct ggc ttg ctg cat 2659 Ile Tyr Asn Gly Val Ala Met Val Leu Ala Val Ser Gly Leu Leu His 840 845 850 cca atg gct gcg acc gtg gct atg ctg gcg tct tcg ctg ctt att gaa 2707 Pro Met Ala Ala Thr Val Ala Met Leu Ala Ser Ser Leu Leu Ile Glu 855 860 865 tgg cgc tcg ggc agg gcg cgc aag tac taaccagcaa ttcccaagcc 2754 Trp Arg Ser Gly Arg Ala Arg Lys Tyr 870 875 caaaaacccc 2764 <210> 18 <211> 878 <212> PRT <213> Corynebacterium glutamicum <400> 18 Val Ser Thr Pro Asp Ser Ser Ser Val Asp Lys Ala Val Asn Thr Ala 1 5 10 15 Ile Ser Asp Ala Lys Thr Ala Ala Leu Lys Ala Gly Val Gly Leu Asn 20 25 30 Arg Ala Thr Ala Ser Glu Glu Glu Glu Asp Leu Ser Ser Ser Ile Lys 35 40 45 Val Ser Leu Ala Phe Glu Leu Glu Gly Leu Ser Asn Ala Pro Ser Leu 50 55 60 Met Val Val Glu Lys Ala Leu Glu Lys Ile Pro Gly Val Ser Ala Asp 65 70 75 80 Leu Ile Tyr Pro Ser Gln Thr Ala Trp Ile Thr Ala Thr Asp Arg Val 85 90 95 His Pro Glu Thr Leu Ile Glu Val Phe Glu Gln Phe Gly Ile Lys Ala 100 105 110 His Leu Ser Asn Ser Ser Leu Leu Arg Arg His Gln Gln Leu Ser Ala 115 120 125 Glu Val Asn Arg Glu Ala Arg Leu Asp Arg Tyr Arg Ser Arg Met Asp 130 135 140 Ala Lys Arg Ile Ser Pro Arg Val Arg Arg His Asn Arg Gln Glu Met 145 150 155 160 Val His Ala Val Arg Ala Arg Glu Ser Gly Trp Ile Lys Arg Arg Asn 165 170 175 His Thr Thr Ser Gln His Glu Asp Pro Met Ser Gly Asp Val Leu Phe 180 185 190 Thr Ala Arg Ala Leu Ile Thr Pro Lys Arg Leu Trp Val Ser Leu Pro 195 200 205 Phe Ala Leu Ile Val Leu Ala Leu Ser Leu Asn Pro Ser Trp Gln Phe 210 215 220 Asp Tyr Trp Gln Trp Leu Ser Ala Val Leu Ala Ile Pro Val Val Val 225 230 235 240 Trp Gly Ala Trp Pro Phe His Arg Ala Ala Ala Gly Gly Ile Arg Arg 245 250 255 Gly Ile Ser Ala Leu Asp Ala Thr Ser Ser Ile Ala Ile Ala Ala Ala 260 265 270 Tyr Ala Trp Ser Ile Ala Met Leu Leu Phe Glu Thr Pro Gly Gly Lys 275 280 285 Ser Trp Arg Ser Tyr Pro Ser Trp Phe Ala Phe Asp His Gly Thr Leu 290 295 300 Thr Gln Asn Glu Ile Tyr Phe Asp Val Ala Cys Gly Ile Thr Val Leu 305 310 315 320 Leu Leu Ala Gly Arg Leu Leu Thr Arg Arg Arg Ser Gln Ser Ser Leu 325 330 335 Leu Ala Glu Leu Gly Arg Leu Gln Ile Asp Pro Gln Arg Ile Val Thr 340 345 350 Val Val Arg Lys His Arg Leu Lys Arg Val Val Gln Glu Leu Asn Ile 355 360 365 Pro Val Gln Glu Val Arg Val Asn Asp Asp Val Lys Val Pro Pro Asn 370 375 380 Thr Thr Ile Pro Val Asp Gly Thr Val Ile Gly Gly Gly Ser Arg Ile 385 390 395 400 Ala Ala Ser Ile Ile Met Gly Gln Asp Gln Arg Asp Val Lys Val Asn 405 410 415 Asp Lys Val Phe Ala Gly Ser Leu Asn Leu Glu Ser Glu Ile Lys Val 420 425 430 Arg Val Ile Arg Thr Gly His Arg Thr Arg Ile Ala Ala Val His Arg 435 440 445 Trp Val Lys Glu Ala Thr Leu Lys Glu Asn Arg His Asn Arg Ala Ala 450 455 460 Ile Arg Ser Ala Gly Asn Leu Val Pro Ile Thr Phe Thr Leu Ala Val 465 470 475 480 Val Asp Phe Cys Leu Trp Ala Leu Ile Ser Gly Asn Ile Asn Ala Ala 485 490 495 Phe Thr Thr Thr Leu Ala Val Leu Ala Cys Val Ala Pro Val Ala Leu 500 505 510 Ala Leu Ser Ala Pro Leu Ala Thr Arg Asn Ser Ile Glu Ala Ala Ala 515 520 525 Arg His Gly Ile Leu Val Arg Ser Gly Glu Ile Phe Arg Val Leu Asp 530 535 540 Asp Val Asp Thr Ala Val Phe Asn Arg Val Gly Thr Leu Thr Asp Gly 545 550 555 560 Glu Met Thr Val Glu Thr Val Thr Ala Asp Lys Gly Glu Asp Pro Glu 565 570 575 Leu Val Leu Arg Val Ala Gly Ala Leu Ala Met Glu Ser His His Ala 580 585 590 Ile Ser Lys Ala Leu Val Lys Ala Ser Arg Glu Ala Arg Asp Thr Gly 595 600 605 Ala Gly Gly Glu Asp Val Pro His Trp Ile Glu Val Gly Asn Val Glu 610 615 620 Ile Thr Glu Ala Gly Ser Phe Gln Ala Thr Ile Glu Leu Pro Leu Ile 625 630 635 640 Lys Pro Ser Gly Glu Lys Ile Met Arg Thr Thr Glu Ala Leu Leu Trp 645 650 655 Arg Pro Arg Ser Met Thr Glu Val Arg Glu His Leu Ser Pro Arg Leu 660 665 670 Val Ala Ala Ala Thr Ser Gly Gly Ala Pro Leu Ile Val Arg Trp Lys 675 680 685 Gly Lys Asp Arg Gly Val Ile Thr Leu Ser Asp His Val Arg Ser Asp 690 695 700 Ser Ser Asp Ala Ile Ile Ala Ile Glu Glu Gln Gly Ile Glu Thr Met 705 710 715 720 Met Leu Ser Arg Asp Thr Tyr Pro Val Ala Arg Arg Tyr Ala Asp Ser 725 730 735 Leu Gly Ile Thr His Val Leu Ala Gly Ile Ala Pro Gly Lys Lys Ala 740 745 750 Gln Val Val Arg Ala Val His Thr Arg Gly Ser Thr Val Ala Met Ile 755 760 765 Gly Asp Glu Ser Val Met Asp Cys Leu Lys Val Ala Asp Val Gly Val 770 775 780 Leu Met Gly Val Asp Arg Pro Ser Asp Leu Arg Asp Asp Ser Asp Asp 785 790 795 800 Pro Ala Ala Asp Val Val Val Met Arg Glu Glu Val Met Ser Val Pro 805 810 815 Thr Leu Phe Lys Leu Ala Arg Arg Tyr Ala Lys Leu Val Asn Gly Asn 820 825 830 Ile Ala Leu Ala Trp Ile Tyr Asn Gly Val Ala Met Val Leu Ala Val 835 840 845 Ser Gly Leu Leu His Pro Met Ala Ala Thr Val Ala Met Leu Ala Ser 850 855 860 Ser Leu Leu Ile Glu Trp Arg Ser Gly Arg Ala Arg Lys Tyr 865 870 875 <210> 19 <211> 1261 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1231) <223> RXA00412 <400> 19 caatcacagc ctgaaaatca gactgtgaac ttcaaacgcc ccgcttggaa tcttttgacg 60 aacaccacgt cgcgtacgct tcctcggggc gttaaactat ttg tct tcc agc ttt 115 Leu Ser Ser Ser Phe 1 5 tgt ccc ccg act ttt gta cga atc gag gac acc gtc gtg tca cac acc 163 Cys Pro Pro Thr Phe Val Arg Ile Glu Asp Thr Val Val Ser His Thr 10 15 20 gcg tcc aca ccg acg cca gag gaa tac tcc gcg cag caa ccc agc acc 211 Ala Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln Gln Pro Ser Thr 25 30 35 cag ggc act cgc gtt gag ttc cgc ggc ata acc aaa gtc ttt agc aac 259 Gln Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys Val Phe Ser Asn 40 45 50 aat aaa tct gct aaa acc acc gcg ctt gat aat gtc act ctc acc gta 307 Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val Thr Leu Thr Val 55 60 65 gaa ccc ggt gag gta atc ggc atc atc ggt tac tct ggc gcc ggc aag 355 Glu Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser Gly Ala Gly Lys 70 75 80 85 tcc act ctt gtc cgc ctc atc aat ggc ctt gac tcc ccc acg agc ggt 403 Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser Pro Thr Ser Gly 90 95 100 tcg ttg ctg ctc aac ggc acc gac atc gtc gga atg ccc gag tct aag 451 Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met Pro Glu Ser Lys 105 110 115 ctg cgt aaa ctg cgc agt aat atc ggc atg att ttc cag cag ttc aac 499 Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe Gln Gln Phe Asn 120 125 130 ctg ttc cag tcg cgt act gcg gct gga aat gtg gag tac ccg ctg gaa 547 Leu Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu Tyr Pro Leu Glu 135 140 145 gtt gcc aag atg gac aag gca gct cgt aaa gct cgc gtg caa gaa atg 595 Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg Val Gln Glu Met 150 155 160 165 ctc gag ttc gtc ggc ctg ggc gac aaa ggc aaa aac tac ccc gag cag 643 Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn Tyr Pro Glu Gln 170 175 180 ctg tcg ggc ggc cag aag cag cgc gtc ggc att gcc cgt gca ctg gcc 691 Leu Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala Arg Ala Leu Ala 185 190 195 acc aat cca acg ctt ttg ctt gcc gac gaa gcc acc tcc gct ttg gac 739 Thr Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr Ser Ala Leu Asp 200 205 210 cca gaa acc acc cat gaa gtt ctg gag ctg ctg cgc aag gta aac cgc 787 Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg Lys Val Asn Arg 215 220 225 gaa ctg ggc atc acc atc gtt gtg atc acc cac gaa atg gaa gtt gtg 835 Glu Leu Gly Ile Thr Ile Val Val Ile Thr His Glu Met Glu Val Val 230 235 240 245 cgt tcc atc gca gac aag gtt gct gtg atg gaa tcc ggc aaa gtt gtg 883 Arg Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser Gly Lys Val Val 250 255 260 gaa tac ggc agc gtc tac gag gtg ttc tcc aat cca caa aca cag gtt 931 Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro Gln Thr Gln Val 265 270 275 gct caa aag ttc gtg gcc acc gcg ctg cgt aac acc cca gac caa gtg 979 Ala Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr Pro Asp Gln Val 280 285 290 gaa tcg gaa gat ctg ctt agc cat gag gga cgt ctg ttc acc att gat 1027 Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu Phe Thr Ile Asp 295 300 305 ctg act gaa acg tcc ggc ttc ttt gca gca acc gct cgt gct gcc gaa 1075 Leu Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala Arg Ala Ala Glu 310 315 320 325 caa ggt gct ttt gtc aac atc gtt cac ggt ggc gtg acc acc ttg caa 1123 Gln Gly Ala Phe Val Asn Ile Val His Gly Gly Val Thr Thr Leu Gln 330 335 340 cgc caa tca ttt ggc aaa atg act gtt cga ctc acc ggc aac acc gct 1171 Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr Gly Asn Thr Ala 345 350 355 gcg att gaa gag ttc tat caa acc ttg acc aag acc acg acc atc aag 1219 Ala Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr Thr Thr Ile Lys 360 365 370 gag atc acc cga tgaacgagat gatcctcgca gctgactgga 1261 Glu Ile Thr Arg 375 <210> 20 <211> 377 <212> PRT <213> Corynebacterium glutamicum <400> 20 Leu Ser Ser Ser Phe Cys Pro Pro Thr Phe Val Arg Ile Glu Asp Thr 1 5 10 15 Val Val Ser His Thr Ala Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala 20 25 30 Gln Gln Pro Ser Thr Gln Gly Thr Arg Val Glu Phe Arg Gly Ile Thr 35 40 45 Lys Val Phe Ser Asn Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn 50 55 60 Val Thr Leu Thr Val Glu Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr 65 70 75 80 Ser Gly Ala Gly Lys Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp 85 90 95 Ser Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly 100 105 110 Met Pro Glu Ser Lys Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile 115 120 125 Phe Gln Gln Phe Asn Leu Phe Gln Ser Arg Thr Ala Ala Gly Asn Val 130 135 140 Glu Tyr Pro Leu Glu Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala 145 150 155 160 Arg Val Gln Glu Met Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys 165 170 175 Asn Tyr Pro Glu Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Gly Ile 180 185 190 Ala Arg Ala Leu Ala Thr Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala 195 200 205 Thr Ser Ala Leu Asp Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu 210 215 220 Arg Lys Val Asn Arg Glu Leu Gly Ile Thr Ile Val Val Ile Thr His 225 230 235 240 Glu Met Glu Val Val Arg Ser Ile Ala Asp Lys Val Ala Val Met Glu 245 250 255 Ser Gly Lys Val Val Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn 260 265 270 Pro Gln Thr Gln Val Ala Gln Lys Phe Val Ala Thr Ala Leu Arg Asn 275 280 285 Thr Pro Asp Gln Val Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg 290 295 300 Leu Phe Thr Ile Asp Leu Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr 305 310 315 320 Ala Arg Ala Ala Glu Gln Gly Ala Phe Val Asn Ile Val His Gly Gly 325 330 335 Val Thr Thr Leu Gln Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu 340 345 350 Thr Gly Asn Thr Ala Ala Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys 355 360 365 Thr Thr Thr Ile Lys Glu Ile Thr Arg 370 375 <210> 21 <211> 1033 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1003) <223> RXA00413 <400> 21 accaagctgt acagatcgcg gtctatggtg ctaatctcct aaatacttga atgaccattt 60 catgatccat tcacaaaaac tttcccaaac aaggacgtat ttg aaa atg aaa ctt 115 Leu Lys Met Lys Leu 1 5 cgt cgc atc aca acc acc gcc atc gct ggc ctc ttc gcc gca acc gca 163 Arg Arg Ile Thr Thr Thr Ala Ile Ala Gly Leu Phe Ala Ala Thr Ala 10 15 20 ctt gtt gcc tgt ggc tcc gat tcc gat gga agc agc acc act gtt gct 211 Leu Val Ala Cys Gly Ser Asp Ser Asp Gly Ser Ser Thr Thr Val Ala 25 30 35 gaa ggc acc gaa ggc gtg acc atc cgc atc ggc acc acc gac gct gcg 259 Glu Gly Thr Glu Gly Val Thr Ile Arg Ile Gly Thr Thr Asp Ala Ala 40 45 50 aag gaa gca tgg acc gta ttc gaa gac aag gca gct gaa gag ggc atc 307 Lys Glu Ala Trp Thr Val Phe Glu Asp Lys Ala Ala Glu Glu Gly Ile 55 60 65 acc ctc gac atc gtt cct ttc tct gac tac tcc acc cca aat gag gct 355 Thr Leu Asp Ile Val Pro Phe Ser Asp Tyr Ser Thr Pro Asn Glu Ala 70 75 80 85 ctt gcc cag gat cag ctg gac gtt aac ctc ttc cag cac ctg aag ttc 403 Leu Ala Gln Asp Gln Leu Asp Val Asn Leu Phe Gln His Leu Lys Phe 90 95 100 ctg gct gag tac aac gtc ggc tcc ggc gca gac ctc acc cca gtt ggc 451 Leu Ala Glu Tyr Asn Val Gly Ser Gly Ala Asp Leu Thr Pro Val Gly 105 110 115 tcc agc gaa atc gtg cca ctg gca cta ttc tgg aag gac cac gac tcc 499 Ser Ser Glu Ile Val Pro Leu Ala Leu Phe Trp Lys Asp His Asp Ser 120 125 130 atc gac ggc att gac ggc gag tcc gtt gcc atc cct aac gat cct tcc 547 Ile Asp Gly Ile Asp Gly Glu Ser Val Ala Ile Pro Asn Asp Pro Ser 135 140 145 aac cag ggc cgc gcc atc aac gtt ctc gtt cag gca ggt ctg gtc acc 595 Asn Gln Gly Arg Ala Ile Asn Val Leu Val Gln Ala Gly Leu Val Thr 150 155 160 165 ctg aag acc cca ggt ctg gtc acc cca gct cca gtc gat atc gac gag 643 Leu Lys Thr Pro Gly Leu Val Thr Pro Ala Pro Val Asp Ile Asp Glu 170 175 180 gca gct tcc aag gtt tcc gtc atc cca gtc gac gca gct cag gca cca 691 Ala Ala Ser Lys Val Ser Val Ile Pro Val Asp Ala Ala Gln Ala Pro 185 190 195 acc gct tac cag gag ggt cgc cca gcg atc atc aac aac tcc ttc ctt 739 Thr Ala Tyr Gln Glu Gly Arg Pro Ala Ile Ile Asn Asn Ser Phe Leu 200 205 210 gac cgc gca ggc atc gat cca aac ctc gcg gtc ttc gaa gat gat cct 787 Asp Arg Ala Gly Ile Asp Pro Asn Leu Ala Val Phe Glu Asp Asp Pro 215 220 225 gag tct gaa gaa gca gag cca tac atc aac gtc ttc gtc acc aag gct 835 Glu Ser Glu Glu Ala Glu Pro Tyr Ile Asn Val Phe Val Thr Lys Ala 230 235 240 245 gag gac aag gac gat gcc aac atc gcc cgc ctc gtt gag ctg tgg cac 883 Glu Asp Lys Asp Asp Ala Asn Ile Ala Arg Leu Val Glu Leu Trp His 250 255 260 gac cca gag gtt ctg gct gca gta gac cgc gac tct gag ggc acc tcc 931 Asp Pro Glu Val Leu Ala Ala Val Asp Arg Asp Ser Glu Gly Thr Ser 265 270 275 gtc cca gtt gat cgt cca gga gct gac ctt cag gaa atc ctt gat cgc 979 Val Pro Val Asp Arg Pro Gly Ala Asp Leu Gln Glu Ile Leu Asp Arg 280 285 290 ctt gag gct gat cag gaa aac gca taatctcttt tgagttcttt gcatacccat 1033 Leu Glu Ala Asp Gln Glu Asn Ala 295 300 <210> 22 <211> 301 <212> PRT <213> Corynebacterium glutamicum <400> 22 Leu Lys Met Lys Leu Arg Arg Ile Thr Thr Thr Ala Ile Ala Gly Leu 1 5 10 15 Phe Ala Ala Thr Ala Leu Val Ala Cys Gly Ser Asp Ser Asp Gly Ser 20 25 30 Ser Thr Thr Val Ala Glu Gly Thr Glu Gly Val Thr Ile Arg Ile Gly 35 40 45 Thr Thr Asp Ala Ala Lys Glu Ala Trp Thr Val Phe Glu Asp Lys Ala 50 55 60 Ala Glu Glu Gly Ile Thr Leu Asp Ile Val Pro Phe Ser Asp Tyr Ser 65 70 75 80 Thr Pro Asn Glu Ala Leu Ala Gln Asp Gln Leu Asp Val Asn Leu Phe 85 90 95 Gln His Leu Lys Phe Leu Ala Glu Tyr Asn Val Gly Ser Gly Ala Asp 100 105 110 Leu Thr Pro Val Gly Ser Ser Glu Ile Val Pro Leu Ala Leu Phe Trp 115 120 125 Lys Asp His Asp Ser Ile Asp Gly Ile Asp Gly Glu Ser Val Ala Ile 130 135 140 Pro Asn Asp Pro Ser Asn Gln Gly Arg Ala Ile Asn Val Leu Val Gln 145 150 155 160 Ala Gly Leu Val Thr Leu Lys Thr Pro Gly Leu Val Thr Pro Ala Pro 165 170 175 Val Asp Ile Asp Glu Ala Ala Ser Lys Val Ser Val Ile Pro Val Asp 180 185 190 Ala Ala Gln Ala Pro Thr Ala Tyr Gln Glu Gly Arg Pro Ala Ile Ile 195 200 205 Asn Asn Ser Phe Leu Asp Arg Ala Gly Ile Asp Pro Asn Leu Ala Val 210 215 220 Phe Glu Asp Asp Pro Glu Ser Glu Glu Ala Glu Pro Tyr Ile Asn Val 225 230 235 240 Phe Val Thr Lys Ala Glu Asp Lys Asp Asp Ala Asn Ile Ala Arg Leu 245 250 255 Val Glu Leu Trp His Asp Pro Glu Val Leu Ala Ala Val Asp Arg Asp 260 265 270 Ser Glu Gly Thr Ser Val Pro Val Asp Arg Pro Gly Ala Asp Leu Gln 275 280 285 Glu Ile Leu Asp Arg Leu Glu Ala Asp Gln Glu Asn Ala 290 295 300 <210> 23 <211> 1615 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1585) <223> RXA00432 <400> 23 agctaatctg ccttgcttta cacctccggg ctataacaat ccagtgccag tggctaggga 60 tttactaaaa atcgggtaac acgcgcgtag tatttttcgc atg gaa tta ttg gag 115 Met Glu Leu Leu Glu 1 5 acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg ccc 163 Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu Pro 10 15 20 ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg ctg 211 Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu Leu 25 30 35 gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag aag 259 Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu Lys 40 45 50 cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct ttt 307 Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala Phe 55 60 65 aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat gtt 355 Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn Val 70 75 80 85 gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg ttc 403 Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val Phe 90 95 100 tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att gag 451 Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile Glu 105 110 115 tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat cgc 499 Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr Arg 120 125 130 ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg ctt 547 Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp Leu 135 140 145 gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg tac 595 Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val Tyr 150 155 160 165 aac gct ttg cag tcc aac gcg gtt gtt gag gcg att acg gta tca ctc 643 Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala Ile Thr Val Ser Leu 170 175 180 ggc acc cct tct acc act gca aag gct ttt gtt ggc ttg ggc atg gct 691 Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val Gly Leu Gly Met Ala 185 190 195 gga ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac 739 Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn 200 205 210 gtg acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg 787 Val Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val 215 220 225 ggt gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc 835 Gly Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile 230 235 240 245 aac gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg 883 Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala 250 255 260 tcg gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt 931 Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg 265 270 275 gga ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct 979 Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala 280 285 290 gct acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act 1027 Ala Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr 295 300 305 ctg ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt 1075 Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe 310 315 320 325 gtc atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct 1123 Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser 330 335 340 tct tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga 1171 Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly 345 350 355 acc cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg 1219 Thr His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val 360 365 370 ctg ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat 1267 Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp 375 380 385 tcg aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg 1315 Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val 390 395 400 405 ttc tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat 1363 Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp 410 415 420 act ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg 1411 Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro 425 430 435 ctg ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag 1459 Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys 440 445 450 aag gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt 1507 Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val 455 460 465 cgt aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat 1555 Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr 470 475 480 485 cac gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 1605 His Glu Ala Met Glu Val Ile Lys Lys Ser 490 495 gtatggcccg 1615 <210> 24 <211> 495 <212> PRT <213> Corynebacterium glutamicum <400> 24 Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu 1 5 10 15 Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly 20 25 30 Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys 35 40 45 Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln 50 55 60 Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val 65 70 75 80 Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly 85 90 95 Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala 100 105 110 Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp 115 120 125 Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu 130 135 140 Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr 145 150 155 160 Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala 165 170 175 Ile Thr Val Ser Leu Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val 180 185 190 Gly Leu Gly Met Ala Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val 195 200 205 Gln Arg Ile Ala Asn Val Thr Gln Trp Met Val Pro Phe Met Ala Gly 210 215 220 Ala Tyr Ile Ile Val Gly Val Val Val Ile Val Ile Asn Ile Gln Gln 225 230 235 240 Val Pro Thr Met Ile Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg 245 250 255 Pro Val Ala Thr Ala Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met 260 265 270 Asn Gly Met Arg Arg Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser 275 280 285 Val Pro Asn Ala Ala Ala Thr Ala Thr Val Ser His Pro Val Lys Gln 290 295 300 Gly Leu Val Gln Thr Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys 305 310 315 320 Ser Ile Thr Ala Phe Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr 325 330 335 Gly Asp Ile Gln Ser Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val 340 345 350 Val Gly Gly Trp Gly Thr His Phe Ile Thr Val Val Met Phe Phe Leu 355 360 365 Ala Phe Ser Ser Val Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile 370 375 380 Gln Tyr Phe Thr Asp Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu 385 390 395 400 Val Leu Leu Ser Val Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile 405 410 415 Trp Ala Leu Gly Asp Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu 420 425 430 Ala Ala Ile Ile Pro Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn 435 440 445 Tyr Thr Ile Gln Lys Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp 450 455 460 Met Met Pro Glu Val Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala 465 470 475 480 Ala Thr Ser Asn Tyr His Glu Ala Met Glu Val Ile Lys Lys Ser 485 490 495 <210> 25 <211> 2533 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2503) <223> RXA00453 <400> 25 aagaagcgtc ggatctagga gattttctcg gattcacagc taccgcaggt aagttagtgg 60 ggcgtgaaaa aatagctcat ttaagaggag aagcaacccc gtg gcg aaa ttg cta 115 Val Ala Lys Leu Leu 1 5 ttc agg ttg ggg cga tgg tcc tat aat cgc aag tgg att gtg att tcg 163 Phe Arg Leu Gly Arg Trp Ser Tyr Asn Arg Lys Trp Ile Val Ile Ser 10 15 20 gca tgg cta ctt att ttg gcc att gtt ggt ggt ctg gcc ctg acg atg 211 Ala Trp Leu Leu Ile Leu Ala Ile Val Gly Gly Leu Ala Leu Thr Met 25 30 35 cag aag ggg ttc agt aac tct ttc act att gaa gac acc cct tcg att 259 Gln Lys Gly Phe Ser Asn Ser Phe Thr Ile Glu Asp Thr Pro Ser Ile 40 45 50 gat gcc act gtt tct ctg gtt gaa aat ttc cct gat cag acg aac ccg 307 Asp Ala Thr Val Ser Leu Val Glu Asn Phe Pro Asp Gln Thr Asn Pro 55 60 65 gtg acg gcc gcc gga gtt aac gtg gtt ttc caa tcc ccg gaa gga acc 355 Val Thr Ala Ala Gly Val Asn Val Val Phe Gln Ser Pro Glu Gly Thr 70 75 80 85 acg ctt gat gat cct cag atg atg act gcg atg gat gca gtc gtt gat 403 Thr Leu Asp Asp Pro Gln Met Met Thr Ala Met Asp Ala Val Val Asp 90 95 100 tac att gag gac aat ttg cct gat ttt ggt ggg gga gag cgc ttc ggc 451 Tyr Ile Glu Asp Asn Leu Pro Asp Phe Gly Gly Gly Glu Arg Phe Gly 105 110 115 aat cct gtt gag gtg tct cct gcg ttg gaa gag atg gtc atc gag cag 499 Asn Pro Val Glu Val Ser Pro Ala Leu Glu Glu Met Val Ile Glu Gln 120 125 130 atg acc agc atg ggg ctt cct gag gaa acc gct gca aag gat gct gcc 547 Met Thr Ser Met Gly Leu Pro Glu Glu Thr Ala Ala Lys Asp Ala Ala 135 140 145 aat ctg gcg gtg ttg agc gaa gac aaa acc att ggc tac acc tct ttc 595 Asn Leu Ala Val Leu Ser Glu Asp Lys Thr Ile Gly Tyr Thr Ser Phe 150 155 160 165 aac att gat gtt gag gcc gca gaa tat gtg gag caa aaa cac cgc gat 643 Asn Ile Asp Val Glu Ala Ala Glu Tyr Val Glu Gln Lys His Arg Asp 170 175 180 gtg atc aac gaa gcg atg caa atc ggt gaa gat tta ggt gtc cgg gtg 691 Val Ile Asn Glu Ala Met Gln Ile Gly Glu Asp Leu Gly Val Arg Val 185 190 195 gaa gcc ggt gga cct gct ttc ggt gat cca att cag att gaa acc acc 739 Glu Ala Gly Gly Pro Ala Phe Gly Asp Pro Ile Gln Ile Glu Thr Thr 200 205 210 agt gag atc atc ggt att ggc atc gcg ttc atc gtg ttg att ttc acc 787 Ser Glu Ile Ile Gly Ile Gly Ile Ala Phe Ile Val Leu Ile Phe Thr 215 220 225 ttt ggt tct ttg att gct gca ggc ttg cct ttg att acc gcg gtg atc 835 Phe Gly Ser Leu Ile Ala Ala Gly Leu Pro Leu Ile Thr Ala Val Ile 230 235 240 245 ggc gtg ggc att ggt gcg ctg gca att gtg ctg gcc acg gcg ttt act 883 Gly Val Gly Ile Gly Ala Leu Ala Ile Val Leu Ala Thr Ala Phe Thr 250 255 260 gat ctc aac aat gtg act cca gtg ctc gca gtg atg att ggc ctg gcc 931 Asp Leu Asn Asn Val Thr Pro Val Leu Ala Val Met Ile Gly Leu Ala 265 270 275 gtg ggc att gac tac gcg ctg ttt att ttg tct agg tac cgt gcg gag 979 Val Gly Ile Asp Tyr Ala Leu Phe Ile Leu Ser Arg Tyr Arg Ala Glu 280 285 290 tat aag cgc atg cca cgt gcc gat gct gcc gga atg gcg gtg ggc aca 1027 Tyr Lys Arg Met Pro Arg Ala Asp Ala Ala Gly Met Ala Val Gly Thr 295 300 305 gct ggt agt gcg gtg gtg ttt gct ggc gcg acg gtg att atc gcg ctg 1075 Ala Gly Ser Ala Val Val Phe Ala Gly Ala Thr Val Ile Ile Ala Leu 310 315 320 325 gta gcc ctc atc att gcg gat atc gga ttc ctc acg gcc atg ggt att 1123 Val Ala Leu Ile Ile Ala Asp Ile Gly Phe Leu Thr Ala Met Gly Ile 330 335 340 tct gcg gcg ttt acg gtg ttc gtg gct gtg ctc att gcg ttg acg ttt 1171 Ser Ala Ala Phe Thr Val Phe Val Ala Val Leu Ile Ala Leu Thr Phe 345 350 355 atc ccg gcg ctg ttg ggt gtg ttt ggt ggt cat gcg ttc aag ggc aag 1219 Ile Pro Ala Leu Leu Gly Val Phe Gly Gly His Ala Phe Lys Gly Lys 360 365 370 atc cct gga att ggt gga aac cca acg cca aag cag acg tgg gag caa 1267 Ile Pro Gly Ile Gly Gly Asn Pro Thr Pro Lys Gln Thr Trp Glu Gln 375 380 385 gcg ctt aat cgt cgt tcc aag ggt cgc tca tgg gtc aag ctt gta cag 1315 Ala Leu Asn Arg Arg Ser Lys Gly Arg Ser Trp Val Lys Leu Val Gln 390 395 400 405 aaa gca ccg ggt ctt gtg gtg gca gtg gtg gtc ttg ggt ctt ggt gcc 1363 Lys Ala Pro Gly Leu Val Val Ala Val Val Val Leu Gly Leu Gly Ala 410 415 420 ttg acc att cct gca atg aac ctg cag ttg tca ctg cct tct gac tcc 1411 Leu Thr Ile Pro Ala Met Asn Leu Gln Leu Ser Leu Pro Ser Asp Ser 425 430 435 acc tcc aat att gat acc act cag cgt cag tcg gct gat ttg atg gca 1459 Thr Ser Asn Ile Asp Thr Thr Gln Arg Gln Ser Ala Asp Leu Met Ala 440 445 450 gag ggc ttt ggc gcg ggc gtt aat gcg ccg ttc ttg gtc atc gtc gat 1507 Glu Gly Phe Gly Ala Gly Val Asn Ala Pro Phe Leu Val Ile Val Asp 455 460 465 acg cat gag gtc aat gct gat tcc acc gca ttg cag cca ctg att gag 1555 Thr His Glu Val Asn Ala Asp Ser Thr Ala Leu Gln Pro Leu Ile Glu 470 475 480 485 gca cag gag cct gaa gag ggc gag ttc gat cgg gag cag gcg gct cgt 1603 Ala Gln Glu Pro Glu Glu Gly Glu Phe Asp Arg Glu Gln Ala Ala Arg 490 495 500 ttt gct acc tat atg tat gtc acc cag acc tac aat tcc aac atc gat 1651 Phe Ala Thr Tyr Met Tyr Val Thr Gln Thr Tyr Asn Ser Asn Ile Asp 505 510 515 gtg aag aat gcg cag atc atc agc gtc aat gat gat ttc act gcg gcg 1699 Val Lys Asn Ala Gln Ile Ile Ser Val Asn Asp Asp Phe Thr Ala Ala 520 525 530 cag att ctc gtg act cca tac acc gga cct gcg gat aaa gag acc cct 1747 Gln Ile Leu Val Thr Pro Tyr Thr Gly Pro Ala Asp Lys Glu Thr Pro 535 540 545 gag ttg atg cac gtg ctg cgt gcg cag gaa gct cag att gag gat gtt 1795 Glu Leu Met His Val Leu Arg Ala Gln Glu Ala Gln Ile Glu Asp Val 550 555 560 565 acg gga act gaa ctg ggt acc act ggg ttt acg gcg gtt cag ttg gac 1843 Thr Gly Thr Glu Leu Gly Thr Thr Gly Phe Thr Ala Val Gln Leu Asp 570 575 580 att act gag cag ctg gaa gac gca atg ccg gtt tac ctc gct gtg gtt 1891 Ile Thr Glu Gln Leu Glu Asp Ala Met Pro Val Tyr Leu Ala Val Val 585 590 595 gtt ggt ttg gct att ttc ctc ctc att ctg gtg ttc cgt tcc ctg ctt 1939 Val Gly Leu Ala Ile Phe Leu Leu Ile Leu Val Phe Arg Ser Leu Leu 600 605 610 gtt ccg ctg gtt gct ggc ctt ggc ttc ttg ttg tct gtg ggt gcg gcc 1987 Val Pro Leu Val Ala Gly Leu Gly Phe Leu Leu Ser Val Gly Ala Ala 615 620 625 ttc ggt gcg acg gtg ttg gtc tgg cag gag ggc ttc ggt ggc ttt gtg 2035 Phe Gly Ala Thr Val Leu Val Trp Gln Glu Gly Phe Gly Gly Phe Val 630 635 640 645 aac acc cct ggt ccg ctg att tcc ttc atg ccg atc ttc ctc atc ggc 2083 Asn Thr Pro Gly Pro Leu Ile Ser Phe Met Pro Ile Phe Leu Ile Gly 650 655 660 gtg acc ttc ggt ttg gcc atg gac tat cag gtg ttc ctt gtg act cgc 2131 Val Thr Phe Gly Leu Ala Met Asp Tyr Gln Val Phe Leu Val Thr Arg 665 670 675 atg cgc gag cac tac acc cac cac aat ggc aag gga cag cct ggt tcc 2179 Met Arg Glu His Tyr Thr His His Asn Gly Lys Gly Gln Pro Gly Ser 680 685 690 aag tac acc ccg gtt gag cag tca gtg att gaa ggc ttc acg cag ggc 2227 Lys Tyr Thr Pro Val Glu Gln Ser Val Ile Glu Gly Phe Thr Gln Gly 695 700 705 tcc cgc gtg gtt aca gca gcg gca ctg atc atg att gcc gtg ttc gtg 2275 Ser Arg Val Val Thr Ala Ala Ala Leu Ile Met Ile Ala Val Phe Val 710 715 720 725 gcg ttt att gat cag ccg ttg cca ttt att aag atc ttc ggt ttc gcg 2323 Ala Phe Ile Asp Gln Pro Leu Pro Phe Ile Lys Ile Phe Gly Phe Ala 730 735 740 ttg ggt gcg ggc gtg ttt ttc gat gct ttc ttc att cgc atg ggt ctg 2371 Leu Gly Ala Gly Val Phe Phe Asp Ala Phe Phe Ile Arg Met Gly Leu 745 750 755 gtc ccc gcg tcg atg ttc ctg atg ggc aag gcc acg tgg tgg atg cct 2419 Val Pro Ala Ser Met Phe Leu Met Gly Lys Ala Thr Trp Trp Met Pro 760 765 770 aag tgg ctg gat cga att ctg cca agt ttg gac att gaa ggc acc gca 2467 Lys Trp Leu Asp Arg Ile Leu Pro Ser Leu Asp Ile Glu Gly Thr Ala 775 780 785 ctg gag aag gaa tgg gag gag aag cag gct gca cgt tagacttggc 2513 Leu Glu Lys Glu Trp Glu Glu Lys Gln Ala Ala Arg 790 795 800 acctatgtca gatctttcat 2533 <210> 26 <211> 801 <212> PRT <213> Corynebacterium glutamicum <400> 26 Val Ala Lys Leu Leu Phe Arg Leu Gly Arg Trp Ser Tyr Asn Arg Lys 1 5 10 15 Trp Ile Val Ile Ser Ala Trp Leu Leu Ile Leu Ala Ile Val Gly Gly 20 25 30 Leu Ala Leu Thr Met Gln Lys Gly Phe Ser Asn Ser Phe Thr Ile Glu 35 40 45 Asp Thr Pro Ser Ile Asp Ala Thr Val Ser Leu Val Glu Asn Phe Pro 50 55 60 Asp Gln Thr Asn Pro Val Thr Ala Ala Gly Val Asn Val Val Phe Gln 65 70 75 80 Ser Pro Glu Gly Thr Thr Leu Asp Asp Pro Gln Met Met Thr Ala Met 85 90 95 Asp Ala Val Val Asp Tyr Ile Glu Asp Asn Leu Pro Asp Phe Gly Gly 100 105 110 Gly Glu Arg Phe Gly Asn Pro Val Glu Val Ser Pro Ala Leu Glu Glu 115 120 125 Met Val Ile Glu Gln Met Thr Ser Met Gly Leu Pro Glu Glu Thr Ala 130 135 140 Ala Lys Asp Ala Ala Asn Leu Ala Val Leu Ser Glu Asp Lys Thr Ile 145 150 155 160 Gly Tyr Thr Ser Phe Asn Ile Asp Val Glu Ala Ala Glu Tyr Val Glu 165 170 175 Gln Lys His Arg Asp Val Ile Asn Glu Ala Met Gln Ile Gly Glu Asp 180 185 190 Leu Gly Val Arg Val Glu Ala Gly Gly Pro Ala Phe Gly Asp Pro Ile 195 200 205 Gln Ile Glu Thr Thr Ser Glu Ile Ile Gly Ile Gly Ile Ala Phe Ile 210 215 220 Val Leu Ile Phe Thr Phe Gly Ser Leu Ile Ala Ala Gly Leu Pro Leu 225 230 235 240 Ile Thr Ala Val Ile Gly Val Gly Ile Gly Ala Leu Ala Ile Val Leu 245 250 255 Ala Thr Ala Phe Thr Asp Leu Asn Asn Val Thr Pro Val Leu Ala Val 260 265 270 Met Ile Gly Leu Ala Val Gly Ile Asp Tyr Ala Leu Phe Ile Leu Ser 275 280 285 Arg Tyr Arg Ala Glu Tyr Lys Arg Met Pro Arg Ala Asp Ala Ala Gly 290 295 300 Met Ala Val Gly Thr Ala Gly Ser Ala Val Val Phe Ala Gly Ala Thr 305 310 315 320 Val Ile Ile Ala Leu Val Ala Leu Ile Ile Ala Asp Ile Gly Phe Leu 325 330 335 Thr Ala Met Gly Ile Ser Ala Ala Phe Thr Val Phe Val Ala Val Leu 340 345 350 Ile Ala Leu Thr Phe Ile Pro Ala Leu Leu Gly Val Phe Gly Gly His 355 360 365 Ala Phe Lys Gly Lys Ile Pro Gly Ile Gly Gly Asn Pro Thr Pro Lys 370 375 380 Gln Thr Trp Glu Gln Ala Leu Asn Arg Arg Ser Lys Gly Arg Ser Trp 385 390 395 400 Val Lys Leu Val Gln Lys Ala Pro Gly Leu Val Val Ala Val Val Val 405 410 415 Leu Gly Leu Gly Ala Leu Thr Ile Pro Ala Met Asn Leu Gln Leu Ser 420 425 430 Leu Pro Ser Asp Ser Thr Ser Asn Ile Asp Thr Thr Gln Arg Gln Ser 435 440 445 Ala Asp Leu Met Ala Glu Gly Phe Gly Ala Gly Val Asn Ala Pro Phe 450 455 460 Leu Val Ile Val Asp Thr His Glu Val Asn Ala Asp Ser Thr Ala Leu 465 470 475 480 Gln Pro Leu Ile Glu Ala Gln Glu Pro Glu Glu Gly Glu Phe Asp Arg 485 490 495 Glu Gln Ala Ala Arg Phe Ala Thr Tyr Met Tyr Val Thr Gln Thr Tyr 500 505 510 Asn Ser Asn Ile Asp Val Lys Asn Ala Gln Ile Ile Ser Val Asn Asp 515 520 525 Asp Phe Thr Ala Ala Gln Ile Leu Val Thr Pro Tyr Thr Gly Pro Ala 530 535 540 Asp Lys Glu Thr Pro Glu Leu Met His Val Leu Arg Ala Gln Glu Ala 545 550 555 560 Gln Ile Glu Asp Val Thr Gly Thr Glu Leu Gly Thr Thr Gly Phe Thr 565 570 575 Ala Val Gln Leu Asp Ile Thr Glu Gln Leu Glu Asp Ala Met Pro Val 580 585 590 Tyr Leu Ala Val Val Val Gly Leu Ala Ile Phe Leu Leu Ile Leu Val 595 600 605 Phe Arg Ser Leu Leu Val Pro Leu Val Ala Gly Leu Gly Phe Leu Leu 610 615 620 Ser Val Gly Ala Ala Phe Gly Ala Thr Val Leu Val Trp Gln Glu Gly 625 630 635 640 Phe Gly Gly Phe Val Asn Thr Pro Gly Pro Leu Ile Ser Phe Met Pro 645 650 655 Ile Phe Leu Ile Gly Val Thr Phe Gly Leu Ala Met Asp Tyr Gln Val 660 665 670 Phe Leu Val Thr Arg Met Arg Glu His Tyr Thr His His Asn Gly Lys 675 680 685 Gly Gln Pro Gly Ser Lys Tyr Thr Pro Val Glu Gln Ser Val Ile Glu 690 695 700 Gly Phe Thr Gln Gly Ser Arg Val Val Thr Ala Ala Ala Leu Ile Met 705 710 715 720 Ile Ala Val Phe Val Ala Phe Ile Asp Gln Pro Leu Pro Phe Ile Lys 725 730 735 Ile Phe Gly Phe Ala Leu Gly Ala Gly Val Phe Phe Asp Ala Phe Phe 740 745 750 Ile Arg Met Gly Leu Val Pro Ala Ser Met Phe Leu Met Gly Lys Ala 755 760 765 Thr Trp Trp Met Pro Lys Trp Leu Asp Arg Ile Leu Pro Ser Leu Asp 770 775 780 Ile Glu Gly Thr Ala Leu Glu Lys Glu Trp Glu Glu Lys Gln Ala Ala 785 790 795 800 Arg <210> 27 <211> 1483 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1453) <223> RXA00456 <400> 27 gcggtgctaa cggatcatgc ctagcttatg gcgtgctcgt cgcagacttt tgctcattgc 60 cctaggtgta cttggtgtgc tgcaggcact gctggcgatc atg gtg tcg ttg agc 115 Met Val Ser Leu Ser 1 5 gta gcc gcc ata ctt gag gga aac cga gca ctt gtt gga ttg ctg ctt 163 Val Ala Ala Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu 10 15 20 gct acc acg ttg ggt ttg ggg gtg gcg cag tgg att caa aaa gta gtg 211 Ala Thr Thr Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val 25 30 35 gca gaa gat cta ggc cag cat tat gtg cat gag gtg cgt cgt gaa ttg 259 Ala Glu Asp Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu 40 45 50 gtg ggt gct gcg ctg gtg cct gga aat acg gcc tcg ttg ggc gtg act 307 Val Gly Ala Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr 55 60 65 gtc acc cga gcc agc aat gat ctc acc gcg gtg cgc aat tgg gtg gct 355 Val Thr Arg Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala 70 75 80 85 ttg ggc att gtt ccg atg gtc acc ggg ctg ccg ttg att gcg att gtg 403 Leu Gly Ile Val Pro Met Val Thr Gly Leu Pro Leu Ile Ala Ile Val 90 95 100 ctg gtg gcg ttg ttt atc caa gat ctc cgc aca ggc gtg gct gtt act 451 Leu Val Ala Leu Phe Ile Gln Asp Leu Arg Thr Gly Val Ala Val Thr 105 110 115 gtg cca ctg ctc atg tgt gta gcc gtg ctg ccg gtg gtg gcg cgg tgg 499 Val Pro Leu Leu Met Cys Val Ala Val Leu Pro Val Val Ala Arg Trp 120 125 130 act ttg aaa aga gca cgt gaa cta cgc aaa aaa cgt gga cgc atg gct 547 Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala 135 140 145 gcg cgg atc gca gat tct gtc atg gct gga gaa tta ctg cac gca aca 595 Ala Arg Ile Ala Asp Ser Val Met Ala Gly Glu Leu Leu His Ala Thr 150 155 160 165 gga gca ata gac cgt gag ctc aat gca gtc acc cga gat tcc gac cga 643 Gly Ala Ile Asp Arg Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg 170 175 180 gtg gtg ata gct gct gta aga cgt tcc tgg gcc acc ggt ttt agc cgc 691 Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg 185 190 195 gca ttg atg gcc atg gca gcc tcg ctt ggc act gtc agc att gtg att 739 Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile 200 205 210 tct ggc cac ctg gaa gta agt gag gtt gcg gga ata atg atg ctt ctt 787 Ser Gly His Leu Glu Val Ser Glu Val Ala Gly Ile Met Met Leu Leu 215 220 225 ggc gtt ctt gcc act cca gtt gca gaa ctt ggc cgc gtg gtg gaa tat 835 Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr 230 235 240 245 cgc caa aat tat aaa gcc gcg aca cgc atc ctg att cca ctt ctg caa 883 Arg Gln Asn Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln 250 255 260 cga ggc tca gaa ttt aaa cac tcc caa caa aaa cta ccc ggg ttg caa 931 Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln 265 270 275 gca aca gaa gga atc ccc ggt gtc tat gtc aaa ggt att tcc gcc ctt 979 Ala Thr Glu Gly Ile Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu 280 285 290 cct gga gaa cgg atc tac ctc cac ggc tct gca gat gcg acg aga aaa 1027 Pro Gly Glu Arg Ile Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys 295 300 305 tgg gtc acc tcg ttg tct gca atg gag gaa ggc aca gat gta ata gtc 1075 Trp Val Thr Ser Leu Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val 310 315 320 325 aac ggt caa agg ctt tcg cag ctt cct ttg aaa caa cga cgc gcc ctc 1123 Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu 330 335 340 atc gga atc gcc tca gca cac cac cac tta agc cgt ggt tca gta tcg 1171 Ile Gly Ile Ala Ser Ala His His His Leu Ser Arg Gly Ser Val Ser 345 350 355 cgc ctg gtt ggt ttg cga gtg ccg gat gcc acc gtg gaa gaa att gag 1219 Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu 360 365 370 caa gca ctg gaa caa gtt ggt ctg aac aac acc ggg aaa caa cgc ttg 1267 Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu 375 380 385 aaa aac ggc gga cac ccc tgg agt act tcg cag atc aac aaa ctg aaa 1315 Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys 390 395 400 405 att gcc agc gcc acc ctt cga acc cca ccg ctt ttg gta ctt gaa ggc 1363 Ile Ala Ser Ala Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly 410 415 420 atc acc cct gaa aac ctc ctc aac tat ccc gga gtg atc atc tcc acc 1411 Ile Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr 425 430 435 gtt cag gag aac cca tcc gaa aca tgg cgg caa gtg aac atc 1453 Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln Val Asn Ile 440 445 450 taatctagaa acatggcagg acgatacgca 1483 <210> 28 <211> 451 <212> PRT <213> Corynebacterium glutamicum <400> 28 Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn Arg Ala Leu 1 5 10 15 Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val Ala Gln Trp 20 25 30 Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr Val His Glu 35 40 45 Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly Asn Thr Ala 50 55 60 Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu Thr Ala Val 65 70 75 80 Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr Gly Leu Pro 85 90 95 Leu Ile Ala Ile Val Leu Val Ala Leu Phe Ile Gln Asp Leu Arg Thr 100 105 110 Gly Val Ala Val Thr Val Pro Leu Leu Met Cys Val Ala Val Leu Pro 115 120 125 Val Val Ala Arg Trp Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys 130 135 140 Arg Gly Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met Ala Gly Glu 145 150 155 160 Leu Leu His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn Ala Val Thr 165 170 175 Arg Asp Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala 180 185 190 Thr Gly Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr 195 200 205 Val Ser Ile Val Ile Ser Gly His Leu Glu Val Ser Glu Val Ala Gly 210 215 220 Ile Met Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly 225 230 235 240 Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr Arg Ile Leu 245 250 255 Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys 260 265 270 Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val Tyr Val Lys 275 280 285 Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His Gly Ser Ala 290 295 300 Asp Ala Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met Glu Glu Gly 305 310 315 320 Thr Asp Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys 325 330 335 Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser Ala His His His Leu Ser 340 345 350 Arg Gly Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr 355 360 365 Val Glu Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr 370 375 380 Gly Lys Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln 385 390 395 400 Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr Pro Pro Leu 405 410 415 Leu Val Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly 420 425 430 Val Ile Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln 435 440 445 Val Asn Ile 450 <210> 29 <211> 1774 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1744) <223> RXA00477 <400> 29 tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60 tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115 Met Lys Val Ser Thr 1 5 aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163 Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val 10 15 20 gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211 Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val 25 30 35 act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259 Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu 40 45 50 gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307 Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp 55 60 65 tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355 Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala 70 75 80 85 tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403 Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg 90 95 100 gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451 Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu 105 110 115 gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499 Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys 120 125 130 cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547 Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile 135 140 145 gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595 Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His 150 155 160 165 cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643 Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg 170 175 180 tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691 Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg 185 190 195 cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739 Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr 200 205 210 acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787 Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly 215 220 225 gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835 Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His 230 235 240 245 cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883 Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val 250 255 260 att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931 Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly 265 270 275 gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979 Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu 280 285 290 gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027 Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro 295 300 305 cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075 Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro 310 315 320 325 gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123 Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro 330 335 340 cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171 Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp 345 350 355 ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219 Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala 360 365 370 tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267 Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val 375 380 385 gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315 Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala 390 395 400 405 tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363 Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala 410 415 420 tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411 Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln 425 430 435 gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459 Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile 440 445 450 ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507 Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala 455 460 465 ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555 Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg 470 475 480 485 aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603 Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr 490 495 500 gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651 Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile 505 510 515 att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699 Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro 520 525 530 ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744 Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His 535 540 545 taaattttga tccctatcat cgatatttca 1774 <210> 30 <211> 548 <212> PRT <213> Corynebacterium glutamicum <400> 30 Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val 1 5 10 15 Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg 20 25 30 Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly 35 40 45 Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp 50 55 60 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe 65 70 75 80 Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu 85 90 95 Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val 100 105 110 Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro 115 120 125 Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala 130 135 140 Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu 145 150 155 160 Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe 165 170 175 Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser 180 185 190 Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser 195 200 205 Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr 210 215 220 Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val 225 230 235 240 Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln 245 250 255 Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn 260 265 270 Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn 275 280 285 Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu 290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 305 310 315 320 Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val 325 330 335 Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu 340 345 350 Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr 355 360 365 Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr 370 375 380 Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met 405 410 415 Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn 420 425 430 Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val 435 440 445 Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser 450 455 460 Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala 465 470 475 480 Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr 485 490 495 Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile 500 505 510 Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly 515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr 530 535 540 Ser Tyr Asp His 545 <210> 31 <211> 1393 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1363) <223> RXA00525 <400> 31 ccatcgtgtt tattactcac aaccctgagc ttgctgatga atctgatcgg gtggtcacca 60 tggttgacgg gcgcatcatt gggtctgagg tgaaacactc atg agc ctt gca gaa 115 Met Ser Leu Ala Glu 1 5 tca att ctt ttg gcg ctc acc agc ctg aga agc aac aag atg cgt gca 163 Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser Asn Lys Met Arg Ala 10 15 20 ttg ttg acg ctg tta gga gtc atc att ggt atc gca tca gtc atc gga 211 Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile Ala Ser Val Ile Gly 25 30 35 att ttg acc att ggt aaa gcc ctg cag gat caa act ttg aat agt ttg 259 Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln Thr Leu Asn Ser Leu 40 45 50 gaa agc ttg ggc gcg aat gat ctg tcg gcg cag gtg gag gaa cgc ccc 307 Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln Val Glu Glu Arg Pro 55 60 65 gac gaa gat tcc ccc gaa ccc gat atg ttc gct ttt tct ggg gct gca 355 Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala Phe Ser Gly Ala Ala 70 75 80 85 aac tct agt ggc aat ctg att ccg gaa gaa aca gtt gat acg ctg cgc 403 Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr Val Asp Thr Leu Arg 90 95 100 gat cgt ttc gca ggc agc atc acg gga atc agc gtt ggc gga atg ggt 451 Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser Val Gly Gly Met Gly 105 110 115 acg caa ggc act ctc atc ggc gac acc gca gat ctt aaa tcc gat ctc 499 Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp Leu Lys Ser Asp Leu 120 125 130 ctc ggc gtc aac gag gat tat atg tgg atg aat ggc gtc gaa atg aac 547 Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn Gly Val Glu Met Asn 135 140 145 tac ggc cgc gcc atc acg caa gac gat gtt gcc gct cag cgc ccc gtt 595 Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala Ala Gln Arg Pro Val 150 155 160 165 gcg gtc atc gcc cca gac acc ttt aat acg ctt ttc gac gca aac ccc 643 Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu Phe Asp Ala Asn Pro 170 175 180 aac ctc gct ctg ggg tcc gaa gta gct ttt gaa ctc aac ggt caa gag 691 Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu Leu Asn Gly Gln Glu 185 190 195 aca ttt ttg cgg gtt atc ggt gtg tat aaa gaa gcc gca gca ggt gga 739 Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu Ala Ala Ala Gly Gly 200 205 210 ctt gtg gga agc aat cca acc gtc cac acc tac acc cca tat acg gtg 787 Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr Thr Pro Tyr Thr Val 215 220 225 gcc aat gac atc acc cac acg gaa gat gga ttg aac acg tta agt atc 835 Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu Asn Thr Leu Ser Ile 230 235 240 245 cgt gca gct cag ggc gta gac cag gat tca ctt aag ggt tca ctg caa 883 Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu Lys Gly Ser Leu Gln 250 255 260 acc tac ttc gac gcg ctg tac gcc aac aat gac tcg cac cac gtt gcc 931 Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp Ser His His Val Ala 265 270 275 atg ttg gac ttc cgt aaa cag atc gaa gag ttc aac acc att ctc ggc 979 Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe Asn Thr Ile Leu Gly 280 285 290 gca atg agt ttg ggt atc tca gcc atc ggc gga att tcc ttg ctt gtc 1027 Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly Ile Ser Leu Leu Val 295 300 305 ggt ggc atc gga gtg atg aac att atg ttg gtg tct gtc acc gag cga 1075 Gly Gly Ile Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg 310 315 320 325 acc cgc gaa atc ggt gtc cga aaa gcc ctc ggc gct cgt cga cgt gac 1123 Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly Ala Arg Arg Arg Asp 330 335 340 att cgc ctg caa ttc gtc gtt gaa gcc atg atc att tgt ttc atc ggt 1171 Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile Ile Cys Phe Ile Gly 345 350 355 ggc atc ctc ggc gtg ctt ttg ggc ggc att ttg gga ttg atc atg tcc 1219 Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu Gly Leu Ile Met Ser 360 365 370 agc gct att ggc tac att tcc ttg cca cca ctg agt gga atc gtg atc 1267 Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu Ser Gly Ile Val Ile 375 380 385 gcc ttg gta ttt tcc atg gct atc ggc ctg ttt ttc ggc tac tac ccc 1315 Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe Phe Gly Tyr Tyr Pro 390 395 400 405 gcc aac aag gca gca aag ctc gat cca att gac gcc ttg cgt tat gag 1363 Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp Ala Leu Arg Tyr Glu 410 415 420 taaaagcctc gtttttaagg tagccacaca 1393 <210> 32 <211> 421 <212> PRT <213> Corynebacterium glutamicum <400> 32 Met Ser Leu Ala Glu Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser 1 5 10 15 Asn Lys Met Arg Ala Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile 20 25 30 Ala Ser Val Ile Gly Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln 35 40 45 Thr Leu Asn Ser Leu Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln 50 55 60 Val Glu Glu Arg Pro Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala 65 70 75 80 Phe Ser Gly Ala Ala Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr 85 90 95 Val Asp Thr Leu Arg Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser 100 105 110 Val Gly Gly Met Gly Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp 115 120 125 Leu Lys Ser Asp Leu Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn 130 135 140 Gly Val Glu Met Asn Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala 145 150 155 160 Ala Gln Arg Pro Val Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu 165 170 175 Phe Asp Ala Asn Pro Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu 180 185 190 Leu Asn Gly Gln Glu Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu 195 200 205 Ala Ala Ala Gly Gly Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr 210 215 220 Thr Pro Tyr Thr Val Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu 225 230 235 240 Asn Thr Leu Ser Ile Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu 245 250 255 Lys Gly Ser Leu Gln Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp 260 265 270 Ser His His Val Ala Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe 275 280 285 Asn Thr Ile Leu Gly Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly 290 295 300 Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val 305 310 315 320 Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly 325 330 335 Ala Arg Arg Arg Asp Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile 340 345 350 Ile Cys Phe Ile Gly Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu 355 360 365 Gly Leu Ile Met Ser Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu 370 375 380 Ser Gly Ile Val Ile Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe 385 390 395 400 Phe Gly Tyr Tyr Pro Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp 405 410 415 Ala Leu Arg Tyr Glu 420 <210> 33 <211> 820 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(790) <223> RXA00526 <400> 33 ggtggagcag gcggcggctc cttttagtcc tgcggcccct tttgaccctg cagcccctgc 60 cgtttctgcc aagcaaaccg tgggccaggt gatttagcct atg agc ctc atc gaa 115 Met Ser Leu Ile Glu 1 5 atg cga aat att gtc aag acc tac aac att gga tct gaa ggt gaa ctc 163 Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly Ser Glu Gly Glu Leu 10 15 20 acc gtg ttg cac ggt gtg gat ttc cat gtg gac cgt ggc gaa ttc gtg 211 Thr Val Leu His Gly Val Asp Phe His Val Asp Arg Gly Glu Phe Val 25 30 35 tcg gtt gtg ggt acg tcc ggc tca ggt aaa tca acg atg atg aac atc 259 Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser Thr Met Met Asn Ile 40 45 50 att ggg ttg ttg gat aag cca act gat ggc acg tac acc ttg gat ggc 307 Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly 55 60 65 gtg gat gtg ttg gat atc agc gat gat gct ttg gcg agc cac cgc gct 355 Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu Ala Ser His Arg Ala 70 75 80 85 aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctg att ggc cgg atc 403 Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn Leu Ile Gly Arg Ile 90 95 100 gat gcg ttg aag aat gtg gaa atg ccc atg atg tat gcg ggc att ccg 451 Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Tyr Ala Gly Ile Pro 105 110 115 gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499 Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu Leu Glu Met Val Gly 120 125 130 atg ggt gag cgt ctc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547 Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu Leu Ser Gly Gly Gln 135 140 145 aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat cct gag atc 595 Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala Asn Asp Pro Glu Ile 150 155 160 165 att ctt gct gat gaa cca act ggt gcg ttg gat tct gca acg ggc cgg 643 Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Ser Ala Thr Gly Arg 170 175 180 atg gtg atg gat att ttc cac cag ctc aac aag gag cag ggc aaa acc 691 Met Val Met Asp Ile Phe His Gln Leu Asn Lys Glu Gln Gly Lys Thr 185 190 195 atc gtg ttt att act cac aac cct gag ctt gct gat gaa tct gat cgg 739 Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala Asp Glu Ser Asp Arg 200 205 210 gtg gtc acc atg gtt gac ggg cgc atc att ggg tct gag gtg aaa cac 787 Val Val Thr Met Val Asp Gly Arg Ile Ile Gly Ser Glu Val Lys His 215 220 225 tca tgagccttgc agaatcaatt cttttggcgc 820 Ser 230 <210> 34 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 34 Met Ser Leu Ile Glu Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly 1 5 10 15 Ser Glu Gly Glu Leu Thr Val Leu His Gly Val Asp Phe His Val Asp 20 25 30 Arg Gly Glu Phe Val Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser 35 40 45 Thr Met Met Asn Ile Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr 50 55 60 Tyr Thr Leu Asp Gly Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu 65 70 75 80 Ala Ser His Arg Ala Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn 85 90 95 Leu Ile Gly Arg Ile Asp Ala Leu Lys Asn Val Glu Met Pro Met Met 100 105 110 Tyr Ala Gly Ile Pro Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu 115 120 125 Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu 130 135 140 Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala 145 150 155 160 Asn Asp Pro Glu Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp 165 170 175 Ser Ala Thr Gly Arg Met Val Met Asp Ile Phe His Gln Leu Asn Lys 180 185 190 Glu Gln Gly Lys Thr Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala 195 200 205 Asp Glu Ser Asp Arg Val Val Thr Met Val Asp Gly Arg Ile Ile Gly 210 215 220 Ser Glu Val Lys His Ser 225 230 <210> 35 <211> 1621 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1591) <223> RXA00634 <400> 35 gtgatcaagc tcgcgcaagc tggggttttc cattttcctc cgtcacttgg tttggatgta 60 tatctgcagt gtaataggtt aattgaacag tgttcaattt ttg gcg cta agt gtt 115 Leu Ala Leu Ser Val 1 5 ttt aat tac cgc agc ttt gtc tta gga gaa gtc atg gtc caa ctg gat 163 Phe Asn Tyr Arg Ser Phe Val Leu Gly Glu Val Met Val Gln Leu Asp 10 15 20 caa cgg gtt agg ttc aaa agc gca acc tca ata atc agt att gaa atg 211 Gln Arg Val Arg Phe Lys Ser Ala Thr Ser Ile Ile Ser Ile Glu Met 25 30 35 tgg gag cga ttc agc ttc tac ggc atg caa gca ctc ttg gtg tac tac 259 Trp Glu Arg Phe Ser Phe Tyr Gly Met Gln Ala Leu Leu Val Tyr Tyr 40 45 50 ctg tat ttt gat gtt gca gcc ggt gga tta ggc ctt gat caa acc caa 307 Leu Tyr Phe Asp Val Ala Ala Gly Gly Leu Gly Leu Asp Gln Thr Gln 55 60 65 gca aca gga ctg gtc ggc gtt tat ggc gca ctg ctc tac ctc tgc tgt 355 Ala Thr Gly Leu Val Gly Val Tyr Gly Ala Leu Leu Tyr Leu Cys Cys 70 75 80 85 tgg gca ggc ggt tgg gtc agt gac aga gtc ctg ggc gca gaa aaa acc 403 Trp Ala Gly Gly Trp Val Ser Asp Arg Val Leu Gly Ala Glu Lys Thr 90 95 100 ctg ctg ggc ggt gcg atc tca gta acc atc gga cac ctt gtg ctt gct 451 Leu Leu Gly Gly Ala Ile Ser Val Thr Ile Gly His Leu Val Leu Ala 105 110 115 ggc ctc ggc ggg aaa att ggt cta gcc att ggc ctt gga tgc atc gcg 499 Gly Leu Gly Gly Lys Ile Gly Leu Ala Ile Gly Leu Gly Cys Ile Ala 120 125 130 atc ggt tca gga ttt gtg aaa aca gca gcc atc acc gtg ctg gga tcc 547 Ile Gly Ser Gly Phe Val Lys Thr Ala Ala Ile Thr Val Leu Gly Ser 135 140 145 agg cat ggt gaa caa gaa gga gac gca aag gca gat ccc gca ttc caa 595 Arg His Gly Glu Gln Glu Gly Asp Ala Lys Ala Asp Pro Ala Phe Gln 150 155 160 165 ctc ttc tac cta ggc atc aac gtt ggt gca ctg ctc gga cca ctc ctg 643 Leu Phe Tyr Leu Gly Ile Asn Val Gly Ala Leu Leu Gly Pro Leu Leu 170 175 180 acc ggt tgg ctc tcc agc agg tat tcc ttt gaa atg gga ttc ggc gca 691 Thr Gly Trp Leu Ser Ser Arg Tyr Ser Phe Glu Met Gly Phe Gly Ala 185 190 195 gcc gca gtc ctt atg atc ggc gga ttg gga atc tac gca gcg ttg cgg 739 Ala Ala Val Leu Met Ile Gly Gly Leu Gly Ile Tyr Ala Ala Leu Arg 200 205 210 aaa cca atg ctg caa tcg ttc ccg ctc gag gtg aag aaa gcg ctg ctc 787 Lys Pro Met Leu Gln Ser Phe Pro Leu Glu Val Lys Lys Ala Leu Leu 215 220 225 cgc gcc caa aac cct gca gaa aaa cat gtg att agc acg gca ttt gct 835 Arg Ala Gln Asn Pro Ala Glu Lys His Val Ile Ser Thr Ala Phe Ala 230 235 240 245 gca gtg gct gtg ctt tgc gga gtg ctg ctt tat ctt ctc ctt aca gaa 883 Ala Val Ala Val Leu Cys Gly Val Leu Leu Tyr Leu Leu Leu Thr Glu 250 255 260 aca gtc agc gca gac caa cta gct gga gct ctg ctt tta gta aca atc 931 Thr Val Ser Ala Asp Gln Leu Ala Gly Ala Leu Leu Leu Val Thr Ile 265 270 275 ggt gca gca cta tgg ctc att atc cag ccc tta cga cac cca caa gtc 979 Gly Ala Ala Leu Trp Leu Ile Ile Gln Pro Leu Arg His Pro Gln Val 280 285 290 agc tcc gaa gag aaa cga aaa gtg ctg gca ttc atc ccg atc ttc gtc 1027 Ser Ser Glu Glu Lys Arg Lys Val Leu Ala Phe Ile Pro Ile Phe Val 295 300 305 tgc tca acc gca ttc tgg gca gtg caa gca caa acc tac ggc gta cta 1075 Cys Ser Thr Ala Phe Trp Ala Val Gln Ala Gln Thr Tyr Gly Val Leu 310 315 320 325 gct gtg tac tcc caa gaa cgt gtt gac cgc atg gtt ggc gat ttt gag 1123 Ala Val Tyr Ser Gln Glu Arg Val Asp Arg Met Val Gly Asp Phe Glu 330 335 340 atc cca gca gcc tgg tca caa tca ctc aat cct ttt ttc atc ctg gcg 1171 Ile Pro Ala Ala Trp Ser Gln Ser Leu Asn Pro Phe Phe Ile Leu Ala 345 350 355 ctg tcc atc ccg att tcc ctg tgg ttt atg cgc gga tca cgc gcc cca 1219 Leu Ser Ile Pro Ile Ser Leu Trp Phe Met Arg Gly Ser Arg Ala Pro 360 365 370 aga gtg aaa att gga atc agc att gga gtg atc att gcg gga agt ggg 1267 Arg Val Lys Ile Gly Ile Ser Ile Gly Val Ile Ile Ala Gly Ser Gly 375 380 385 ctt cta gtt ctt att cca ttt gtt gga atg ccg ctc gcg cca gtg tgg 1315 Leu Leu Val Leu Ile Pro Phe Val Gly Met Pro Leu Ala Pro Val Trp 390 395 400 405 gtg ctg cct tta agt gtt ttc ctc atc tca ctg gga gaa ctt ttc atc 1363 Val Leu Pro Leu Ser Val Phe Leu Ile Ser Leu Gly Glu Leu Phe Ile 410 415 420 gga ccc gga gga atg gct gcg act gcg cac cac gca cca cga ata ttt 1411 Gly Pro Gly Gly Met Ala Ala Thr Ala His His Ala Pro Arg Ile Phe 425 430 435 gcc aca cga ttc tcc gcc ctg tat ttc ctc aca ctc gcc atc ggc atg 1459 Ala Thr Arg Phe Ser Ala Leu Tyr Phe Leu Thr Leu Ala Ile Gly Met 440 445 450 tct att gca ggt aat gtg tcc aaa ttt tac gac ccc acc aac cac acc 1507 Ser Ile Ala Gly Asn Val Ser Lys Phe Tyr Asp Pro Thr Asn His Thr 455 460 465 tcc gag ctc cga tac ttc gcg gta ttt ggc att tcg atc atc gtc atc 1555 Ser Glu Leu Arg Tyr Phe Ala Val Phe Gly Ile Ser Ile Ile Val Ile 470 475 480 485 ggt gtc ggt tca ctg atg gtg gcc aag aag gtt gga taacagggtt 1601 Gly Val Gly Ser Leu Met Val Ala Lys Lys Val Gly 490 495 aatcttgggt gatattgaaa 1621 <210> 36 <211> 497 <212> PRT <213> Corynebacterium glutamicum <400> 36 Leu Ala Leu Ser Val Phe Asn Tyr Arg Ser Phe Val Leu Gly Glu Val 1 5 10 15 Met Val Gln Leu Asp Gln Arg Val Arg Phe Lys Ser Ala Thr Ser Ile 20 25 30 Ile Ser Ile Glu Met Trp Glu Arg Phe Ser Phe Tyr Gly Met Gln Ala 35 40 45 Leu Leu Val Tyr Tyr Leu Tyr Phe Asp Val Ala Ala Gly Gly Leu Gly 50 55 60 Leu Asp Gln Thr Gln Ala Thr Gly Leu Val Gly Val Tyr Gly Ala Leu 65 70 75 80 Leu Tyr Leu Cys Cys Trp Ala Gly Gly Trp Val Ser Asp Arg Val Leu 85 90 95 Gly Ala Glu Lys Thr Leu Leu Gly Gly Ala Ile Ser Val Thr Ile Gly 100 105 110 His Leu Val Leu Ala Gly Leu Gly Gly Lys Ile Gly Leu Ala Ile Gly 115 120 125 Leu Gly Cys Ile Ala Ile Gly Ser Gly Phe Val Lys Thr Ala Ala Ile 130 135 140 Thr Val Leu Gly Ser Arg His Gly Glu Gln Glu Gly Asp Ala Lys Ala 145 150 155 160 Asp Pro Ala Phe Gln Leu Phe Tyr Leu Gly Ile Asn Val Gly Ala Leu 165 170 175 Leu Gly Pro Leu Leu Thr Gly Trp Leu Ser Ser Arg Tyr Ser Phe Glu 180 185 190 Met Gly Phe Gly Ala Ala Ala Val Leu Met Ile Gly Gly Leu Gly Ile 195 200 205 Tyr Ala Ala Leu Arg Lys Pro Met Leu Gln Ser Phe Pro Leu Glu Val 210 215 220 Lys Lys Ala Leu Leu Arg Ala Gln Asn Pro Ala Glu Lys His Val Ile 225 230 235 240 Ser Thr Ala Phe Ala Ala Val Ala Val Leu Cys Gly Val Leu Leu Tyr 245 250 255 Leu Leu Leu Thr Glu Thr Val Ser Ala Asp Gln Leu Ala Gly Ala Leu 260 265 270 Leu Leu Val Thr Ile Gly Ala Ala Leu Trp Leu Ile Ile Gln Pro Leu 275 280 285 Arg His Pro Gln Val Ser Ser Glu Glu Lys Arg Lys Val Leu Ala Phe 290 295 300 Ile Pro Ile Phe Val Cys Ser Thr Ala Phe Trp Ala Val Gln Ala Gln 305 310 315 320 Thr Tyr Gly Val Leu Ala Val Tyr Ser Gln Glu Arg Val Asp Arg Met 325 330 335 Val Gly Asp Phe Glu Ile Pro Ala Ala Trp Ser Gln Ser Leu Asn Pro 340 345 350 Phe Phe Ile Leu Ala Leu Ser Ile Pro Ile Ser Leu Trp Phe Met Arg 355 360 365 Gly Ser Arg Ala Pro Arg Val Lys Ile Gly Ile Ser Ile Gly Val Ile 370 375 380 Ile Ala Gly Ser Gly Leu Leu Val Leu Ile Pro Phe Val Gly Met Pro 385 390 395 400 Leu Ala Pro Val Trp Val Leu Pro Leu Ser Val Phe Leu Ile Ser Leu 405 410 415 Gly Glu Leu Phe Ile Gly Pro Gly Gly Met Ala Ala Thr Ala His His 420 425 430 Ala Pro Arg Ile Phe Ala Thr Arg Phe Ser Ala Leu Tyr Phe Leu Thr 435 440 445 Leu Ala Ile Gly Met Ser Ile Ala Gly Asn Val Ser Lys Phe Tyr Asp 450 455 460 Pro Thr Asn His Thr Ser Glu Leu Arg Tyr Phe Ala Val Phe Gly Ile 465 470 475 480 Ser Ile Ile Val Ile Gly Val Gly Ser Leu Met Val Ala Lys Lys Val 485 490 495 Gly <210> 37 <211> 1432 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1402) <223> RXA00654 <400> 37 gagatcaatt catatctcaa acattgtaca tctgatcagc aatagcgatt attgcttgat 60 tgtgtgtttt tagatcttcg gttctcttca ctcaactgct gtg aag tgc cac ctg 115 Val Lys Cys His Leu 1 5 ttt gga aag gcg aac acg ata gtg ctc gat att ttg att tac ccg gtg 163 Phe Gly Lys Ala Asn Thr Ile Val Leu Asp Ile Leu Ile Tyr Pro Val 10 15 20 tct gga gtg atg aag ctg tgg cac ctg ctt ctt cac aac gtt gcg ggt 211 Ser Gly Val Met Lys Leu Trp His Leu Leu Leu His Asn Val Ala Gly 25 30 35 ttg gac gat tca ctg gcg tgg ttc ttt tcc ctt ttc ggc ctt gtc atc 259 Leu Asp Asp Ser Leu Ala Trp Phe Phe Ser Leu Phe Gly Leu Val Ile 40 45 50 acg atc cgt gca att atc gcg cct ttc acc tgg cag atg tat aag tcg 307 Thr Ile Arg Ala Ile Ile Ala Pro Phe Thr Trp Gln Met Tyr Lys Ser 55 60 65 ggc cgc act gcc gca cat att cgt cct cac cgc gct gcg ctc cgg gaa 355 Gly Arg Thr Ala Ala His Ile Arg Pro His Arg Ala Ala Leu Arg Glu 70 75 80 85 gaa tac aag gga aag tac gat gaa gcg tcc att cgg gag ttg cag aag 403 Glu Tyr Lys Gly Lys Tyr Asp Glu Ala Ser Ile Arg Glu Leu Gln Lys 90 95 100 cgc cag aat gat ttg aat aag gaa tac ggc att aac ccg ctg gca ggt 451 Arg Gln Asn Asp Leu Asn Lys Glu Tyr Gly Ile Asn Pro Leu Ala Gly 105 110 115 tgt gtg cct ggg ctg atc cag ata ccg att gtc ctt ggt ctt tac tgg 499 Cys Val Pro Gly Leu Ile Gln Ile Pro Ile Val Leu Gly Leu Tyr Trp 120 125 130 gca ctt ctc cgc atg gct cgc cct gaa ggt ggt ttg gaa aat ccc gtc 547 Ala Leu Leu Arg Met Ala Arg Pro Glu Gly Gly Leu Glu Asn Pro Val 135 140 145 ttc cag tcg atc ggc ttc cta act cct gag gaa gtg gaa tct ttc ctc 595 Phe Gln Ser Ile Gly Phe Leu Thr Pro Glu Glu Val Glu Ser Phe Leu 150 155 160 165 gct ggt cgc gtg agc aat gtg cct ctg ccc gct tat gtt tcg atg ccc 643 Ala Gly Arg Val Ser Asn Val Pro Leu Pro Ala Tyr Val Ser Met Pro 170 175 180 act gag cag cta aaa tat ttg agc acc acg cag gcg gaa gtt ctt agt 691 Thr Glu Gln Leu Lys Tyr Leu Ser Thr Thr Gln Ala Glu Val Leu Ser 185 190 195 ttc gtt ttg cca ctg ttc atc aca gcc gca atc ctc acc gca atc aac 739 Phe Val Leu Pro Leu Phe Ile Thr Ala Ala Ile Leu Thr Ala Ile Asn 200 205 210 atg gcg atg tcc atg tac cgc agc ttc caa acc aac gat tac gca tcc 787 Met Ala Met Ser Met Tyr Arg Ser Phe Gln Thr Asn Asp Tyr Ala Ser 215 220 225 gga ttc tct aac ggc atg ctg aag ttc atg atc gtg atg tcg atc ctc 835 Gly Phe Ser Asn Gly Met Leu Lys Phe Met Ile Val Met Ser Ile Leu 230 235 240 245 gcg ccg atc ttc cca ctg tcc ctt ggc ctc aca gga cca ttc ccc aca 883 Ala Pro Ile Phe Pro Leu Ser Leu Gly Leu Thr Gly Pro Phe Pro Thr 250 255 260 gca atc gca ctc tat tgg gtc agc aac aac ctg tgg acg ctc ctc caa 931 Ala Ile Ala Leu Tyr Trp Val Ser Asn Asn Leu Trp Thr Leu Leu Gln 265 270 275 aca atc atc atg atg gtc att ttg gaa cgc aaa tac cca ctt acc gac 979 Thr Ile Ile Met Met Val Ile Leu Glu Arg Lys Tyr Pro Leu Thr Asp 280 285 290 gat ttc aaa gtg cac cac cta gag cag cgc gac atc tac cgc gca aaa 1027 Asp Phe Lys Val His His Leu Glu Gln Arg Asp Ile Tyr Arg Ala Lys 295 300 305 caa aaa gaa aag cgc atc ttc ctg tgg aca cga cgc aaa aac cgc gcc 1075 Gln Lys Glu Lys Arg Ile Phe Leu Trp Thr Arg Arg Lys Asn Arg Ala 310 315 320 325 ctg atg att ctc acc cca tgg aac gcc tca acg ctt cac gca aca aac 1123 Leu Met Ile Leu Thr Pro Trp Asn Ala Ser Thr Leu His Ala Thr Asn 330 335 340 gtg gaa ctc acc aaa acc cgt act gcc gaa atc aac gaa gca aaa cag 1171 Val Glu Leu Thr Lys Thr Arg Thr Ala Glu Ile Asn Glu Ala Lys Gln 345 350 355 gcc cgc aaa gaa atc gcg aac aag agg cgc gaa acg caa cgt gaa atg 1219 Ala Arg Lys Glu Ile Ala Asn Lys Arg Arg Glu Thr Gln Arg Glu Met 360 365 370 aac cgc gcc gcc atg cag cgc tta aag cag cgt cgc gct gag gtt aaa 1267 Asn Arg Ala Ala Met Gln Arg Leu Lys Gln Arg Arg Ala Glu Val Lys 375 380 385 gct aaa aag aag ggg ctt atc gac gcc tcc ccc aac gaa gat acc cct 1315 Ala Lys Lys Lys Gly Leu Ile Asp Ala Ser Pro Asn Glu Asp Thr Pro 390 395 400 405 tcg gaa aat gaa gaa act aaa ttg agt agt ccg cag gtg gag ccg aca 1363 Ser Glu Asn Glu Glu Thr Lys Leu Ser Ser Pro Gln Val Glu Pro Thr 410 415 420 aca act gcc gag cca aat cgc gag ccg tct caa gag gac tgatgttgtg 1412 Thr Thr Ala Glu Pro Asn Arg Glu Pro Ser Gln Glu Asp 425 430 gaccaatcga gatccagcaa 1432 <210> 38 <211> 434 <212> PRT <213> Corynebacterium glutamicum <400> 38 Val Lys Cys His Leu Phe Gly Lys Ala Asn Thr Ile Val Leu Asp Ile 1 5 10 15 Leu Ile Tyr Pro Val Ser Gly Val Met Lys Leu Trp His Leu Leu Leu 20 25 30 His Asn Val Ala Gly Leu Asp Asp Ser Leu Ala Trp Phe Phe Ser Leu 35 40 45 Phe Gly Leu Val Ile Thr Ile Arg Ala Ile Ile Ala Pro Phe Thr Trp 50 55 60 Gln Met Tyr Lys Ser Gly Arg Thr Ala Ala His Ile Arg Pro His Arg 65 70 75 80 Ala Ala Leu Arg Glu Glu Tyr Lys Gly Lys Tyr Asp Glu Ala Ser Ile 85 90 95 Arg Glu Leu Gln Lys Arg Gln Asn Asp Leu Asn Lys Glu Tyr Gly Ile 100 105 110 Asn Pro Leu Ala Gly Cys Val Pro Gly Leu Ile Gln Ile Pro Ile Val 115 120 125 Leu Gly Leu Tyr Trp Ala Leu Leu Arg Met Ala Arg Pro Glu Gly Gly 130 135 140 Leu Glu Asn Pro Val Phe Gln Ser Ile Gly Phe Leu Thr Pro Glu Glu 145 150 155 160 Val Glu Ser Phe Leu Ala Gly Arg Val Ser Asn Val Pro Leu Pro Ala 165 170 175 Tyr Val Ser Met Pro Thr Glu Gln Leu Lys Tyr Leu Ser Thr Thr Gln 180 185 190 Ala Glu Val Leu Ser Phe Val Leu Pro Leu Phe Ile Thr Ala Ala Ile 195 200 205 Leu Thr Ala Ile Asn Met Ala Met Ser Met Tyr Arg Ser Phe Gln Thr 210 215 220 Asn Asp Tyr Ala Ser Gly Phe Ser Asn Gly Met Leu Lys Phe Met Ile 225 230 235 240 Val Met Ser Ile Leu Ala Pro Ile Phe Pro Leu Ser Leu Gly Leu Thr 245 250 255 Gly Pro Phe Pro Thr Ala Ile Ala Leu Tyr Trp Val Ser Asn Asn Leu 260 265 270 Trp Thr Leu Leu Gln Thr Ile Ile Met Met Val Ile Leu Glu Arg Lys 275 280 285 Tyr Pro Leu Thr Asp Asp Phe Lys Val His His Leu Glu Gln Arg Asp 290 295 300 Ile Tyr Arg Ala Lys Gln Lys Glu Lys Arg Ile Phe Leu Trp Thr Arg 305 310 315 320 Arg Lys Asn Arg Ala Leu Met Ile Leu Thr Pro Trp Asn Ala Ser Thr 325 330 335 Leu His Ala Thr Asn Val Glu Leu Thr Lys Thr Arg Thr Ala Glu Ile 340 345 350 Asn Glu Ala Lys Gln Ala Arg Lys Glu Ile Ala Asn Lys Arg Arg Glu 355 360 365 Thr Gln Arg Glu Met Asn Arg Ala Ala Met Gln Arg Leu Lys Gln Arg 370 375 380 Arg Ala Glu Val Lys Ala Lys Lys Lys Gly Leu Ile Asp Ala Ser Pro 385 390 395 400 Asn Glu Asp Thr Pro Ser Glu Asn Glu Glu Thr Lys Leu Ser Ser Pro 405 410 415 Gln Val Glu Pro Thr Thr Thr Ala Glu Pro Asn Arg Glu Pro Ser Gln 420 425 430 Glu Asp <210> 39 <211> 1276 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1246) <223> RXA00690 <400> 39 atggatcatt ggactcacac tggctgtcat ttccttggtt tcagcgtctg ctgtggcggc 60 gtgggcgatt cgtcgttcag aggtccaggg ttaaagcttc gtg aaa tgg att gag 115 Val Lys Trp Ile Glu 1 5 cga tat gtg ctg tcc cgg cgg atg gtt cat ccc tgg gcg tgg tgg gtg 163 Arg Tyr Val Leu Ser Arg Arg Met Val His Pro Trp Ala Trp Trp Val 10 15 20 tgg gcg ttg ggt att gct ggt tgt gcc agc atg acc aac aat cct tat 211 Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met Thr Asn Asn Pro Tyr 25 30 35 att ttg gcg ctc act ttt gcc acg ttg tgt ttt gtg gtg ttt aac cgt 259 Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe Val Val Phe Asn Arg 40 45 50 cgt ggg tca tcg ccg tgg tcg cgt gct ttc ccg atc tat ttg atg atc 307 Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro Ile Tyr Leu Met Ile 55 60 65 gcg ggt tgg ctc gtg gtg tac cgg ttg gtc atg cac att gtg gtg gga 355 Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met His Ile Val Val Gly 70 75 80 85 gca aaa att ggc acc att gaa ctg ttt cgg atc ccg ccg gtg cag ttg 403 Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile Pro Pro Val Gln Leu 90 95 100 ccg gaa tgg gct gcg ggt atc cac gtg ttt ggc acg gtg tat ctc gag 451 Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly Thr Val Tyr Leu Glu 105 110 115 ggt ctg atc atc gcg acg acg caa ggc tta acg ctt gga acg atg atc 499 Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr Leu Gly Thr Met Ile 120 125 130 gtg gcg gtg ggt gct gcg aac tct ttg gcg gat ccc aag aag ctg ctc 547 Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp Pro Lys Lys Leu Leu 135 140 145 aaa tcg ttg cct ggc gca ttg ggc gaa ctg gga act gcg gtg gtc atc 595 Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly Thr Ala Val Val Ile 150 155 160 165 ggt att tcc att gca cct cag atg gct gag tcg gcg ttc cgc att aat 643 Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser Ala Phe Arg Ile Asn 170 175 180 cgt gca cga acc ttg cgt ggt gat gat gcc aaa ggt gtt cgt ggt ttc 691 Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys Gly Val Arg Gly Phe 185 190 195 gcg cgg att ttg atg ccg gtt ttc cag gac act ttg gat agg tct ttg 739 Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr Leu Asp Arg Ser Leu 200 205 210 gcc ctg gct aat tcc atg gat gcc cgt ggt tat ggc agg cag gct cat 787 Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr Gly Arg Gln Ala His 215 220 225 gta tcc aaa ttc caa cag cgt gtg acc tct att ttt ggt gca ttc gga 835 Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile Phe Gly Ala Phe Gly 230 235 240 245 ata ctc ggc gtg acc gtt ggt ctg ttt gtg gtc tta gat gca tca tca 883 Ile Leu Gly Val Thr Val Gly Leu Phe Val Val Leu Asp Ala Ser Ser 250 255 260 ccg atg ttc gtt gcc gtt ccg gtg ttt att acc ggc gtg ggc ttc ttg 931 Pro Met Phe Val Ala Val Pro Val Phe Ile Thr Gly Val Gly Phe Leu 265 270 275 atc att tcg ttg gtc gtt gct tca cat aga aaa aca tcc acc act ttt 979 Ile Ile Ser Leu Val Val Ala Ser His Arg Lys Thr Ser Thr Thr Phe 280 285 290 gat cag ttg cct tgg ggt gct gcg gaa tgg ctt gtg tgc atc aca ggt 1027 Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu Val Cys Ile Thr Gly 295 300 305 gtg att ccg ctg ctc atg gct gcg ctg aca cga tac ctt gat cca ggt 1075 Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg Tyr Leu Asp Pro Gly 310 315 320 325 tcc atg atc acc acc tgg gtt cct ttg cat atg cca gac acc gtt ccg 1123 Ser Met Ile Thr Thr Trp Val Pro Leu His Met Pro Asp Thr Val Pro 330 335 340 ttg ctc gtt gtg gca gga ctt gtt gtg gcg acg atg cca gga ttc ttg 1171 Leu Leu Val Val Ala Gly Leu Val Val Ala Thr Met Pro Gly Phe Leu 345 350 355 acg ccc cgc ttg ccg aag aac aaa gtg agg gtc aag cgt cga aaa gca 1219 Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val Lys Arg Arg Lys Ala 360 365 370 ata aat agc cca gaa agg gcc gaa gtt taatgagtgc tccttttagc 1266 Ile Asn Ser Pro Glu Arg Ala Glu Val 375 380 gcgcgcactg 1276 <210> 40 <211> 382 <212> PRT <213> Corynebacterium glutamicum <400> 40 Val Lys Trp Ile Glu Arg Tyr Val Leu Ser Arg Arg Met Val His Pro 1 5 10 15 Trp Ala Trp Trp Val Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met 20 25 30 Thr Asn Asn Pro Tyr Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe 35 40 45 Val Val Phe Asn Arg Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro 50 55 60 Ile Tyr Leu Met Ile Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met 65 70 75 80 His Ile Val Val Gly Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile 85 90 95 Pro Pro Val Gln Leu Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly 100 105 110 Thr Val Tyr Leu Glu Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr 115 120 125 Leu Gly Thr Met Ile Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp 130 135 140 Pro Lys Lys Leu Leu Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly 145 150 155 160 Thr Ala Val Val Ile Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser 165 170 175 Ala Phe Arg Ile Asn Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys 180 185 190 Gly Val Arg Gly Phe Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr 195 200 205 Leu Asp Arg Ser Leu Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr 210 215 220 Gly Arg Gln Ala His Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile 225 230 235 240 Phe Gly Ala Phe Gly Ile Leu Gly Val Thr Val Gly Leu Phe Val Val 245 250 255 Leu Asp Ala Ser Ser Pro Met Phe Val Ala Val Pro Val Phe Ile Thr 260 265 270 Gly Val Gly Phe Leu Ile Ile Ser Leu Val Val Ala Ser His Arg Lys 275 280 285 Thr Ser Thr Thr Phe Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu 290 295 300 Val Cys Ile Thr Gly Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg 305 310 315 320 Tyr Leu Asp Pro Gly Ser Met Ile Thr Thr Trp Val Pro Leu His Met 325 330 335 Pro Asp Thr Val Pro Leu Leu Val Val Ala Gly Leu Val Val Ala Thr 340 345 350 Met Pro Gly Phe Leu Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val 355 360 365 Lys Arg Arg Lys Ala Ile Asn Ser Pro Glu Arg Ala Glu Val 370 375 380 <210> 41 <211> 1888 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1858) <223> RXA00732 <400> 41 ttccgcccca agccacagct agaaaaacgc gtaaccttgg tgagaaacca tgaactgaaa 60 aatcagttcg tggccagctt aaaacccgga catccaccgg gtg act ctc ccc aaa 115 Val Thr Leu Pro Lys 1 5 agg aat aca ttc atg ctg tgg tcg ata ttg gtg agg ttt tta aaa ccc 163 Arg Asn Thr Phe Met Leu Trp Ser Ile Leu Val Arg Phe Leu Lys Pro 10 15 20 gca tgg ccc cta att tta acc gtc atc att ttc caa ttg gcg caa tca 211 Ala Trp Pro Leu Ile Leu Thr Val Ile Ile Phe Gln Leu Ala Gln Ser 25 30 35 atc acc tcc ctc cta ctc ccc acg cta aac gca gac atc att gac aat 259 Ile Thr Ser Leu Leu Leu Pro Thr Leu Asn Ala Asp Ile Ile Asp Asn 40 45 50 ggt gtg gtc aca ggt gat atc ggc tat att tgg cac acc ggt gga atc 307 Gly Val Val Thr Gly Asp Ile Gly Tyr Ile Trp His Thr Gly Gly Ile 55 60 65 atg ctg gcc ctg aca tta gtc cag gtt gcc tgc gct atc gcc ggt gtt 355 Met Leu Ala Leu Thr Leu Val Gln Val Ala Cys Ala Ile Ala Gly Val 70 75 80 85 tat ttc ggt tcc aaa cta tcc atg aga gtg ggc cgc gat ctg cgt tcg 403 Tyr Phe Gly Ser Lys Leu Ser Met Arg Val Gly Arg Asp Leu Arg Ser 90 95 100 gcg atc ttt ggc aag gta gtg aac ttc tct gag cgt gag atg ggt cag 451 Ala Ile Phe Gly Lys Val Val Asn Phe Ser Glu Arg Glu Met Gly Gln 105 110 115 ttt ggc gca ccg tcg ctg atc acc cga aac acc aac gat gtg cag cag 499 Phe Gly Ala Pro Ser Leu Ile Thr Arg Asn Thr Asn Asp Val Gln Gln 120 125 130 gtt cag atg ctg gtg cag atg acc tcc act ttg atg att tcc gcc ccg 547 Val Gln Met Leu Val Gln Met Thr Ser Thr Leu Met Ile Ser Ala Pro 135 140 145 atg ctg gcc att ggt ggc atc atc atg gcg gtg cgt cag gat ctt ggt 595 Met Leu Ala Ile Gly Gly Ile Ile Met Ala Val Arg Gln Asp Leu Gly 150 155 160 165 ttg tct tgg ctg atg gtg gtc agt att ccg gtg ctc atc atc gtg gtg 643 Leu Ser Trp Leu Met Val Val Ser Ile Pro Val Leu Ile Ile Val Val 170 175 180 gcg ctg atc att gtg cgc atg gtt ccg ttg ttc caa acc atg caa aag 691 Ala Leu Ile Ile Val Arg Met Val Pro Leu Phe Gln Thr Met Gln Lys 185 190 195 cgc att gac cgc atc aat cag att ata cgc gag cag ctc acc ggt atc 739 Arg Ile Asp Arg Ile Asn Gln Ile Ile Arg Glu Gln Leu Thr Gly Ile 200 205 210 cgc gtg atc cgc gcg ttc gtg cgt gaa gat gtg gaa cgc gaa cga ttc 787 Arg Val Ile Arg Ala Phe Val Arg Glu Asp Val Glu Arg Glu Arg Phe 215 220 225 acc act gct agt aaa gat gtc gct gat atc ggc gtg cgc acc ggt aac 835 Thr Thr Ala Ser Lys Asp Val Ala Asp Ile Gly Val Arg Thr Gly Asn 230 235 240 245 ctg atg gcg ttg atg ttc cct gcc gtg atg ctg atc atg aac ctt tct 883 Leu Met Ala Leu Met Phe Pro Ala Val Met Leu Ile Met Asn Leu Ser 250 255 260 gcc gtt gct gtg att tgg ttt ggt gct ttc cag gtg gaa tcc ggc gag 931 Ala Val Ala Val Ile Trp Phe Gly Ala Phe Gln Val Glu Ser Gly Glu 265 270 275 acg cag atc ggt acg ctc ttt gca ttc ttg cag tac atc atg cag atc 979 Thr Gln Ile Gly Thr Leu Phe Ala Phe Leu Gln Tyr Ile Met Gln Ile 280 285 290 ctc atg ggc gtc atg atg gca gcg ttc atg ttt gtc atg gtt ccg cgc 1027 Leu Met Gly Val Met Met Ala Ala Phe Met Phe Val Met Val Pro Arg 295 300 305 gct gcc gtt tcc gct gat cgc atc ggt gag gtt ctg gaa acc aca ccg 1075 Ala Ala Val Ser Ala Asp Arg Ile Gly Glu Val Leu Glu Thr Thr Pro 310 315 320 325 tct gtg cag gcg cca gaa aca ccg gcg cag ccg tcg aca agc gct ggc 1123 Ser Val Gln Ala Pro Glu Thr Pro Ala Gln Pro Ser Thr Ser Ala Gly 330 335 340 gaa atc gtg ttc aac aac gcg act ttt gcc tac ccc ggc gcg gat gac 1171 Glu Ile Val Phe Asn Asn Ala Thr Phe Ala Tyr Pro Gly Ala Asp Asp 345 350 355 ccc gtg tta aat aat gtg agc ttc cgc gtt gcg cct ggt agc acg acg 1219 Pro Val Leu Asn Asn Val Ser Phe Arg Val Ala Pro Gly Ser Thr Thr 360 365 370 gcg atc atc ggc tcg acg ggt tcg ggt aag acg acg ttg atc ggg ctg 1267 Ala Ile Ile Gly Ser Thr Gly Ser Gly Lys Thr Thr Leu Ile Gly Leu 375 380 385 gtt cct agg ctt ttc gac gtc acc gaa ggc gac gtt acc gtc gat ggc 1315 Val Pro Arg Leu Phe Asp Val Thr Glu Gly Asp Val Thr Val Asp Gly 390 395 400 405 acc gat gtt cgt gaa ttt gag ccg ctg aag ctg tgg gat cgg atc ggt 1363 Thr Asp Val Arg Glu Phe Glu Pro Leu Lys Leu Trp Asp Arg Ile Gly 410 415 420 ctt gtt ccg cag aag tcg ttc ctg ttt tct gga acg atc gcc agc aac 1411 Leu Val Pro Gln Lys Ser Phe Leu Phe Ser Gly Thr Ile Ala Ser Asn 425 430 435 ctg cgt tat ggc aat gaa gat gcc acg gaa acg cag ctg tgg cag gcg 1459 Leu Arg Tyr Gly Asn Glu Asp Ala Thr Glu Thr Gln Leu Trp Gln Ala 440 445 450 ctt gca att gct cag gcg gcg gac ttt gtg cgt gag atg cca gag ggt 1507 Leu Ala Ile Ala Gln Ala Ala Asp Phe Val Arg Glu Met Pro Glu Gly 455 460 465 ctt gat tct gag att gct cag ggt gga acc aat gtt tct ggt ggt cag 1555 Leu Asp Ser Glu Ile Ala Gln Gly Gly Thr Asn Val Ser Gly Gly Gln 470 475 480 485 cgc cag cga cta gcc att gcc agg gcg ttg ttg aag caa cct gag atc 1603 Arg Gln Arg Leu Ala Ile Ala Arg Ala Leu Leu Lys Gln Pro Glu Ile 490 495 500 tat att ttc gac gat tct ttc tcc gcc ctc gat gtg agc aca gac gcc 1651 Tyr Ile Phe Asp Asp Ser Phe Ser Ala Leu Asp Val Ser Thr Asp Ala 505 510 515 gct ctt cgc cga gcg ctg agc acc aac ctg ccg gat gca acc aag ttg 1699 Ala Leu Arg Arg Ala Leu Ser Thr Asn Leu Pro Asp Ala Thr Lys Leu 520 525 530 att gtc gcc cag cgt gtc agc acg att cga gat gcc gat cag att gtg 1747 Ile Val Ala Gln Arg Val Ser Thr Ile Arg Asp Ala Asp Gln Ile Val 535 540 545 gtg ctt gat aac ggc gag gtt gtc ggt att gga acg cac acg aat ttg 1795 Val Leu Asp Asn Gly Glu Val Val Gly Ile Gly Thr His Thr Asn Leu 550 555 560 565 ctg aac acg tgc ggt acc tac cgt gaa att gtt gaa tcc caa gag act 1843 Leu Asn Thr Cys Gly Thr Tyr Arg Glu Ile Val Glu Ser Gln Glu Thr 570 575 580 gcg cag gcg caa tca tgagtaatac tgcaggcccc cgcgggcgtt 1888 Ala Gln Ala Gln Ser 585 <210> 42 <211> 586 <212> PRT <213> Corynebacterium glutamicum <400> 42 Val Thr Leu Pro Lys Arg Asn Thr Phe Met Leu Trp Ser Ile Leu Val 1 5 10 15 Arg Phe Leu Lys Pro Ala Trp Pro Leu Ile Leu Thr Val Ile Ile Phe 20 25 30 Gln Leu Ala Gln Ser Ile Thr Ser Leu Leu Leu Pro Thr Leu Asn Ala 35 40 45 Asp Ile Ile Asp Asn Gly Val Val Thr Gly Asp Ile Gly Tyr Ile Trp 50 55 60 His Thr Gly Gly Ile Met Leu Ala Leu Thr Leu Val Gln Val Ala Cys 65 70 75 80 Ala Ile Ala Gly Val Tyr Phe Gly Ser Lys Leu Ser Met Arg Val Gly 85 90 95 Arg Asp Leu Arg Ser Ala Ile Phe Gly Lys Val Val Asn Phe Ser Glu 100 105 110 Arg Glu Met Gly Gln Phe Gly Ala Pro Ser Leu Ile Thr Arg Asn Thr 115 120 125 Asn Asp Val Gln Gln Val Gln Met Leu Val Gln Met Thr Ser Thr Leu 130 135 140 Met Ile Ser Ala Pro Met Leu Ala Ile Gly Gly Ile Ile Met Ala Val 145 150 155 160 Arg Gln Asp Leu Gly Leu Ser Trp Leu Met Val Val Ser Ile Pro Val 165 170 175 Leu Ile Ile Val Val Ala Leu Ile Ile Val Arg Met Val Pro Leu Phe 180 185 190 Gln Thr Met Gln Lys Arg Ile Asp Arg Ile Asn Gln Ile Ile Arg Glu 195 200 205 Gln Leu Thr Gly Ile Arg Val Ile Arg Ala Phe Val Arg Glu Asp Val 210 215 220 Glu Arg Glu Arg Phe Thr Thr Ala Ser Lys Asp Val Ala Asp Ile Gly 225 230 235 240 Val Arg Thr Gly Asn Leu Met Ala Leu Met Phe Pro Ala Val Met Leu 245 250 255 Ile Met Asn Leu Ser Ala Val Ala Val Ile Trp Phe Gly Ala Phe Gln 260 265 270 Val Glu Ser Gly Glu Thr Gln Ile Gly Thr Leu Phe Ala Phe Leu Gln 275 280 285 Tyr Ile Met Gln Ile Leu Met Gly Val Met Met Ala Ala Phe Met Phe 290 295 300 Val Met Val Pro Arg Ala Ala Val Ser Ala Asp Arg Ile Gly Glu Val 305 310 315 320 Leu Glu Thr Thr Pro Ser Val Gln Ala Pro Glu Thr Pro Ala Gln Pro 325 330 335 Ser Thr Ser Ala Gly Glu Ile Val Phe Asn Asn Ala Thr Phe Ala Tyr 340 345 350 Pro Gly Ala Asp Asp Pro Val Leu Asn Asn Val Ser Phe Arg Val Ala 355 360 365 Pro Gly Ser Thr Thr Ala Ile Ile Gly Ser Thr Gly Ser Gly Lys Thr 370 375 380 Thr Leu Ile Gly Leu Val Pro Arg Leu Phe Asp Val Thr Glu Gly Asp 385 390 395 400 Val Thr Val Asp Gly Thr Asp Val Arg Glu Phe Glu Pro Leu Lys Leu 405 410 415 Trp Asp Arg Ile Gly Leu Val Pro Gln Lys Ser Phe Leu Phe Ser Gly 420 425 430 Thr Ile Ala Ser Asn Leu Arg Tyr Gly Asn Glu Asp Ala Thr Glu Thr 435 440 445 Gln Leu Trp Gln Ala Leu Ala Ile Ala Gln Ala Ala Asp Phe Val Arg 450 455 460 Glu Met Pro Glu Gly Leu Asp Ser Glu Ile Ala Gln Gly Gly Thr Asn 465 470 475 480 Val Ser Gly Gly Gln Arg Gln Arg Leu Ala Ile Ala Arg Ala Leu Leu 485 490 495 Lys Gln Pro Glu Ile Tyr Ile Phe Asp Asp Ser Phe Ser Ala Leu Asp 500 505 510 Val Ser Thr Asp Ala Ala Leu Arg Arg Ala Leu Ser Thr Asn Leu Pro 515 520 525 Asp Ala Thr Lys Leu Ile Val Ala Gln Arg Val Ser Thr Ile Arg Asp 530 535 540 Ala Asp Gln Ile Val Val Leu Asp Asn Gly Glu Val Val Gly Ile Gly 545 550 555 560 Thr His Thr Asn Leu Leu Asn Thr Cys Gly Thr Tyr Arg Glu Ile Val 565 570 575 Glu Ser Gln Glu Thr Ala Gln Ala Gln Ser 580 585 <210> 43 <211> 1684 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1654) <223> RXA00758 <400> 43 atccgcacga ttgcaaaatc ctggggaata ttcataacaa cggaggtcac tcatgacttt 60 gaagaagtct ctcgctgtaa ccacggcggc tgcacttgct ttg agc ctt gcc gct 115 Leu Ser Leu Ala Ala 1 5 tgc tcg tcc gac tcc tcg tcc gac agc tcc tca tcc tca tca ggc agc 163 Cys Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Ser Ser Ser Gly Ser 10 15 20 gaa ggc ggc gac aac tac gtc ctc gtc aac ggc act gag cca cag aac 211 Glu Gly Gly Asp Asn Tyr Val Leu Val Asn Gly Thr Glu Pro Gln Asn 25 30 35 ccg ctc gtc cca ggc aac acc aac gaa gta ggt ggc ggt cgc atc gtc 259 Pro Leu Val Pro Gly Asn Thr Asn Glu Val Gly Gly Gly Arg Ile Val 40 45 50 gac agc atc ttc tcc ggc ctg gtc tac tac gac gtc gac ggc tcc cct 307 Asp Ser Ile Phe Ser Gly Leu Val Tyr Tyr Asp Val Asp Gly Ser Pro 55 60 65 gtc aac gat gtt gca gag tcc atc gaa ctc gaa ggt gac aag acc tac 355 Val Asn Asp Val Ala Glu Ser Ile Glu Leu Glu Gly Asp Lys Thr Tyr 70 75 80 85 cgc atc acc atc aaa gac ggc cag acc ttc acc gat ggc acc cca gtt 403 Arg Ile Thr Ile Lys Asp Gly Gln Thr Phe Thr Asp Gly Thr Pro Val 90 95 100 acc gct gag agc ttt gtc aac gca tgg aac tac aac gta gct aac agc 451 Thr Ala Glu Ser Phe Val Asn Ala Trp Asn Tyr Asn Val Ala Asn Ser 105 110 115 acg ctg tcc tcc tac ttc ttt gag tcc atc ctc ggc tac gaa gaa ggc 499 Thr Leu Ser Ser Tyr Phe Phe Glu Ser Ile Leu Gly Tyr Glu Glu Gly 120 125 130 gtc gag tcc atg gaa ggc ctc cag gtc gtc gac gac acc acc ttc acc 547 Val Glu Ser Met Glu Gly Leu Gln Val Val Asp Asp Thr Thr Phe Thr 135 140 145 gtc gag ctc acc cag cct gag tcc gac ttc cca ctg cgc ctg gga tac 595 Val Glu Leu Thr Gln Pro Glu Ser Asp Phe Pro Leu Arg Leu Gly Tyr 150 155 160 165 tcc gca ttc ttc ccg ctt cct gaa tcc gca ttt gac gac atg gac gca 643 Ser Ala Phe Phe Pro Leu Pro Glu Ser Ala Phe Asp Asp Met Asp Ala 170 175 180 ttc ggt gag aac cca atc ggc aac ggt cca tac aag ctc caa gag tgg 691 Phe Gly Glu Asn Pro Ile Gly Asn Gly Pro Tyr Lys Leu Gln Glu Trp 185 190 195 aac cac aac cag gac gcc acc atc gtt cct aac gcg gac tac acc ggt 739 Asn His Asn Gln Asp Ala Thr Ile Val Pro Asn Ala Asp Tyr Thr Gly 200 205 210 gga cgc cag gct cag aac gac ggc gtg aag ttc atc ttc tac cca acc 787 Gly Arg Gln Ala Gln Asn Asp Gly Val Lys Phe Ile Phe Tyr Pro Thr 215 220 225 ttc gac tcc gct tac gcg gac ctg ctc tcc gac aac ttg gat gtg ctg 835 Phe Asp Ser Ala Tyr Ala Asp Leu Leu Ser Asp Asn Leu Asp Val Leu 230 235 240 245 gac gct atc cca gac tcc gcg ttc tcc tcc ttc gag gac gag ctc tct 883 Asp Ala Ile Pro Asp Ser Ala Phe Ser Ser Phe Glu Asp Glu Leu Ser 250 255 260 ggc cgt tcc atc aac cag cct tcc gct gtg ttc cag tcc ttc acc atc 931 Gly Arg Ser Ile Asn Gln Pro Ser Ala Val Phe Gln Ser Phe Thr Ile 265 270 275 ccg gag agc ctt gag cac ttc tcc ggc gaa gaa ggc gtg ctg cgt cgc 979 Pro Glu Ser Leu Glu His Phe Ser Gly Glu Glu Gly Val Leu Arg Arg 280 285 290 cag gcc atc tcc ttg gcc gtc aac cgc gac gag atc acc caa acc atc 1027 Gln Ala Ile Ser Leu Ala Val Asn Arg Asp Glu Ile Thr Gln Thr Ile 295 300 305 ttc gaa ggc acc cgc acc cca gcg acg gac ttc acc tcc cct gtc atc 1075 Phe Glu Gly Thr Arg Thr Pro Ala Thr Asp Phe Thr Ser Pro Val Ile 310 315 320 325 gac gga cac tct gat tcc ctc cag ggc gca gat gtc ttg acc tac gat 1123 Asp Gly His Ser Asp Ser Leu Gln Gly Ala Asp Val Leu Thr Tyr Asp 330 335 340 cca gag cgc gct cag gaa ctg tgg gca cag gca gac gag atc agc cct 1171 Pro Glu Arg Ala Gln Glu Leu Trp Ala Gln Ala Asp Glu Ile Ser Pro 345 350 355 tgg tcc ggc gag ttc tcc atc tcc tac aac gca gac ggt gga cac cag 1219 Trp Ser Gly Glu Phe Ser Ile Ser Tyr Asn Ala Asp Gly Gly His Gln 360 365 370 gca tgg gtg gac gca acc gcc aat tcc atc cgc aac acc ctg ggt atc 1267 Ala Trp Val Asp Ala Thr Ala Asn Ser Ile Arg Asn Thr Leu Gly Ile 375 380 385 gac gcc atc ggc aac cca tac cca gac ttc aag tcc ctg cgt gac gat 1315 Asp Ala Ile Gly Asn Pro Tyr Pro Asp Phe Lys Ser Leu Arg Asp Asp 390 395 400 405 gtc acc aac cgc acc atc aac ggc gca ttc cgc acc ggc tgg cag gca 1363 Val Thr Asn Arg Thr Ile Asn Gly Ala Phe Arg Thr Gly Trp Gln Ala 410 415 420 gac tac ccg tcc ttg ggc aac ttc ctc gga cct ttg tac ggc acc ggt 1411 Asp Tyr Pro Ser Leu Gly Asn Phe Leu Gly Pro Leu Tyr Gly Thr Gly 425 430 435 gca ggc tcc aac gat ggt gac tac tcc aac cca gat ttc gat gcc aag 1459 Ala Gly Ser Asn Asp Gly Asp Tyr Ser Asn Pro Asp Phe Asp Ala Lys 440 445 450 ctc gcc gaa gca gca aac gcg gcc gat gtt gac gca tca acc ccg cta 1507 Leu Ala Glu Ala Ala Asn Ala Ala Asp Val Asp Ala Ser Thr Pro Leu 455 460 465 tac aac gaa gca cag gaa atc ctg ctc cag gat ctc cca gcg atc cca 1555 Tyr Asn Glu Ala Gln Glu Ile Leu Leu Gln Asp Leu Pro Ala Ile Pro 470 475 480 485 act tgg tac tcc aac gca gtt ggt gga tac tcc acc aac gtg gac aac 1603 Thr Trp Tyr Ser Asn Ala Val Gly Gly Tyr Ser Thr Asn Val Asp Asn 490 495 500 gtg gaa ttc cag tgg aac tcg caa cct gcg tac tac cag atc acc aag 1651 Val Glu Phe Gln Trp Asn Ser Gln Pro Ala Tyr Tyr Gln Ile Thr Lys 505 510 515 aac tagtagcttc gcaccacccg ctcatcttgt 1684 Asn <210> 44 <211> 518 <212> PRT <213> Corynebacterium glutamicum <400> 44 Leu Ser Leu Ala Ala Cys Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser 1 5 10 15 Ser Ser Ser Gly Ser Glu Gly Gly Asp Asn Tyr Val Leu Val Asn Gly 20 25 30 Thr Glu Pro Gln Asn Pro Leu Val Pro Gly Asn Thr Asn Glu Val Gly 35 40 45 Gly Gly Arg Ile Val Asp Ser Ile Phe Ser Gly Leu Val Tyr Tyr Asp 50 55 60 Val Asp Gly Ser Pro Val Asn Asp Val Ala Glu Ser Ile Glu Leu Glu 65 70 75 80 Gly Asp Lys Thr Tyr Arg Ile Thr Ile Lys Asp Gly Gln Thr Phe Thr 85 90 95 Asp Gly Thr Pro Val Thr Ala Glu Ser Phe Val Asn Ala Trp Asn Tyr 100 105 110 Asn Val Ala Asn Ser Thr Leu Ser Ser Tyr Phe Phe Glu Ser Ile Leu 115 120 125 Gly Tyr Glu Glu Gly Val Glu Ser Met Glu Gly Leu Gln Val Val Asp 130 135 140 Asp Thr Thr Phe Thr Val Glu Leu Thr Gln Pro Glu Ser Asp Phe Pro 145 150 155 160 Leu Arg Leu Gly Tyr Ser Ala Phe Phe Pro Leu Pro Glu Ser Ala Phe 165 170 175 Asp Asp Met Asp Ala Phe Gly Glu Asn Pro Ile Gly Asn Gly Pro Tyr 180 185 190 Lys Leu Gln Glu Trp Asn His Asn Gln Asp Ala Thr Ile Val Pro Asn 195 200 205 Ala Asp Tyr Thr Gly Gly Arg Gln Ala Gln Asn Asp Gly Val Lys Phe 210 215 220 Ile Phe Tyr Pro Thr Phe Asp Ser Ala Tyr Ala Asp Leu Leu Ser Asp 225 230 235 240 Asn Leu Asp Val Leu Asp Ala Ile Pro Asp Ser Ala Phe Ser Ser Phe 245 250 255 Glu Asp Glu Leu Ser Gly Arg Ser Ile Asn Gln Pro Ser Ala Val Phe 260 265 270 Gln Ser Phe Thr Ile Pro Glu Ser Leu Glu His Phe Ser Gly Glu Glu 275 280 285 Gly Val Leu Arg Arg Gln Ala Ile Ser Leu Ala Val Asn Arg Asp Glu 290 295 300 Ile Thr Gln Thr Ile Phe Glu Gly Thr Arg Thr Pro Ala Thr Asp Phe 305 310 315 320 Thr Ser Pro Val Ile Asp Gly His Ser Asp Ser Leu Gln Gly Ala Asp 325 330 335 Val Leu Thr Tyr Asp Pro Glu Arg Ala Gln Glu Leu Trp Ala Gln Ala 340 345 350 Asp Glu Ile Ser Pro Trp Ser Gly Glu Phe Ser Ile Ser Tyr Asn Ala 355 360 365 Asp Gly Gly His Gln Ala Trp Val Asp Ala Thr Ala Asn Ser Ile Arg 370 375 380 Asn Thr Leu Gly Ile Asp Ala Ile Gly Asn Pro Tyr Pro Asp Phe Lys 385 390 395 400 Ser Leu Arg Asp Asp Val Thr Asn Arg Thr Ile Asn Gly Ala Phe Arg 405 410 415 Thr Gly Trp Gln Ala Asp Tyr Pro Ser Leu Gly Asn Phe Leu Gly Pro 420 425 430 Leu Tyr Gly Thr Gly Ala Gly Ser Asn Asp Gly Asp Tyr Ser Asn Pro 435 440 445 Asp Phe Asp Ala Lys Leu Ala Glu Ala Ala Asn Ala Ala Asp Val Asp 450 455 460 Ala Ser Thr Pro Leu Tyr Asn Glu Ala Gln Glu Ile Leu Leu Gln Asp 465 470 475 480 Leu Pro Ala Ile Pro Thr Trp Tyr Ser Asn Ala Val Gly Gly Tyr Ser 485 490 495 Thr Asn Val Asp Asn Val Glu Phe Gln Trp Asn Ser Gln Pro Ala Tyr 500 505 510 Tyr Gln Ile Thr Lys Asn 515 <210> 45 <211> 1054 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1024) <223> RXA00759 <400> 45 tcaccttgaa cacttaaaac ataacttcat ccggcgcttt attagcttga agcgccccgc 60 accataatcc attccccagc aagcaaggac acccacgctc atg ctt cgt tac gtc 115 Met Leu Arg Tyr Val 1 5 ggg cga cgt ttg ctc caa atg att ccg gtc ttt ttc gga gcg acc tta 163 Gly Arg Arg Leu Leu Gln Met Ile Pro Val Phe Phe Gly Ala Thr Leu 10 15 20 ctg att tac gcc ctc gtg ttc ctc atg cct ggt gac cca gtc cag gca 211 Leu Ile Tyr Ala Leu Val Phe Leu Met Pro Gly Asp Pro Val Gln Ala 25 30 35 ttg gga ggt gac cgc ggc cta acc gag gct gcg gcc gag aaa atc cgt 259 Leu Gly Gly Asp Arg Gly Leu Thr Glu Ala Ala Ala Glu Lys Ile Arg 40 45 50 caa gaa tac aat ctt gat aaa ccc ttc atc gtt caa tac ctc ctg tac 307 Gln Glu Tyr Asn Leu Asp Lys Pro Phe Ile Val Gln Tyr Leu Leu Tyr 55 60 65 atc aag ggc atc ttc gtc tta gat ttt gga aca acc ttc tct ggt cag 355 Ile Lys Gly Ile Phe Val Leu Asp Phe Gly Thr Thr Phe Ser Gly Gln 70 75 80 85 cca gtt att gat gtg atg gcc agg gcc ttc ccc gtc acc atc aaa ctc 403 Pro Val Ile Asp Val Met Ala Arg Ala Phe Pro Val Thr Ile Lys Leu 90 95 100 gcc atc atg gcc ctg ctg ttt gaa tca atc ctc ggc att atc ttt ggt 451 Ala Ile Met Ala Leu Leu Phe Glu Ser Ile Leu Gly Ile Ile Phe Gly 105 110 115 gtc atc gca ggt att cgc cgc gga gga atc ttc gac tcc acc gtg ctg 499 Val Ile Ala Gly Ile Arg Arg Gly Gly Ile Phe Asp Ser Thr Val Leu 120 125 130 gtc ctt tct ctg ata gtc atc gca gtc ccc acc ttc gtc att ggt ttc 547 Val Leu Ser Leu Ile Val Ile Ala Val Pro Thr Phe Val Ile Gly Phe 135 140 145 gtg ctg cag ttc tta gtc ggc gtg aaa tgg ggc tta ctg ccc gtc acc 595 Val Leu Gln Phe Leu Val Gly Val Lys Trp Gly Leu Leu Pro Val Thr 150 155 160 165 gta ggt tcc aac aca tca ata acg gcg ctg atc atg ccg gct gtc gta 643 Val Gly Ser Asn Thr Ser Ile Thr Ala Leu Ile Met Pro Ala Val Val 170 175 180 ctg ggt gca gta tcg ttc gcc tac gtt ctt cgc ctc acc aga caa tcc 691 Leu Gly Ala Val Ser Phe Ala Tyr Val Leu Arg Leu Thr Arg Gln Ser 185 190 195 gtg agc gaa aac ctc cgc gct gat tac gtt cga acc gct cga gca aaa 739 Val Ser Glu Asn Leu Arg Ala Asp Tyr Val Arg Thr Ala Arg Ala Lys 200 205 210 ggc atg tcc gga ttc aac gtg atg aac cgc cat gtg ctt cga aac tca 787 Gly Met Ser Gly Phe Asn Val Met Asn Arg His Val Leu Arg Asn Ser 215 220 225 ctg att ccc gtt gcc acc ttc ctg ggc gcc gat ctc ggt gca ctg atg 835 Leu Ile Pro Val Ala Thr Phe Leu Gly Ala Asp Leu Gly Ala Leu Met 230 235 240 245 ggt gga gcg att gtc acc gaa ggt atc ttc ggc atc aac ggt gtc ggt 883 Gly Gly Ala Ile Val Thr Glu Gly Ile Phe Gly Ile Asn Gly Val Gly 250 255 260 gga acg ctc tac cag gcc att ttg aaa ggt gaa ccc acc acg gtt gtc 931 Gly Thr Leu Tyr Gln Ala Ile Leu Lys Gly Glu Pro Thr Thr Val Val 265 270 275 tcc att gtc act gtg ctg gtc atc gtc tac atc atc gcc aac ctt ctc 979 Ser Ile Val Thr Val Leu Val Ile Val Tyr Ile Ile Ala Asn Leu Leu 280 285 290 gtg gac ttg atc tac gcc gtt ctc gat ccg agg atc cgc tat gcc 1024 Val Asp Leu Ile Tyr Ala Val Leu Asp Pro Arg Ile Arg Tyr Ala 295 300 305 taataatgaa ttccacacaa accactcgtt 1054 <210> 46 <211> 308 <212> PRT <213> Corynebacterium glutamicum <400> 46 Met Leu Arg Tyr Val Gly Arg Arg Leu Leu Gln Met Ile Pro Val Phe 1 5 10 15 Phe Gly Ala Thr Leu Leu Ile Tyr Ala Leu Val Phe Leu Met Pro Gly 20 25 30 Asp Pro Val Gln Ala Leu Gly Gly Asp Arg Gly Leu Thr Glu Ala Ala 35 40 45 Ala Glu Lys Ile Arg Gln Glu Tyr Asn Leu Asp Lys Pro Phe Ile Val 50 55 60 Gln Tyr Leu Leu Tyr Ile Lys Gly Ile Phe Val Leu Asp Phe Gly Thr 65 70 75 80 Thr Phe Ser Gly Gln Pro Val Ile Asp Val Met Ala Arg Ala Phe Pro 85 90 95 Val Thr Ile Lys Leu Ala Ile Met Ala Leu Leu Phe Glu Ser Ile Leu 100 105 110 Gly Ile Ile Phe Gly Val Ile Ala Gly Ile Arg Arg Gly Gly Ile Phe 115 120 125 Asp Ser Thr Val Leu Val Leu Ser Leu Ile Val Ile Ala Val Pro Thr 130 135 140 Phe Val Ile Gly Phe Val Leu Gln Phe Leu Val Gly Val Lys Trp Gly 145 150 155 160 Leu Leu Pro Val Thr Val Gly Ser Asn Thr Ser Ile Thr Ala Leu Ile 165 170 175 Met Pro Ala Val Val Leu Gly Ala Val Ser Phe Ala Tyr Val Leu Arg 180 185 190 Leu Thr Arg Gln Ser Val Ser Glu Asn Leu Arg Ala Asp Tyr Val Arg 195 200 205 Thr Ala Arg Ala Lys Gly Met Ser Gly Phe Asn Val Met Asn Arg His 210 215 220 Val Leu Arg Asn Ser Leu Ile Pro Val Ala Thr Phe Leu Gly Ala Asp 225 230 235 240 Leu Gly Ala Leu Met Gly Gly Ala Ile Val Thr Glu Gly Ile Phe Gly 245 250 255 Ile Asn Gly Val Gly Gly Thr Leu Tyr Gln Ala Ile Leu Lys Gly Glu 260 265 270 Pro Thr Thr Val Val Ser Ile Val Thr Val Leu Val Ile Val Tyr Ile 275 280 285 Ile Ala Asn Leu Leu Val Asp Leu Ile Tyr Ala Val Leu Asp Pro Arg 290 295 300 Ile Arg Tyr Ala 305 <210> 47 <211> 1195 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1165) <223> RXA00777 <400> 47 ttaagtgaat cgggcgccct ctcccagcaa ttgggggtag ggcgcccgat tttcctaaca 60 agctttttat caatacgcca gttaaggaaa taaaccacca atg gcc act aat gag 115 Met Ala Thr Asn Glu 1 5 tca gtc tcg gag aag caa cgc ctg gat gca acc agg gtg cag gca cat 163 Ser Val Ser Glu Lys Gln Arg Leu Asp Ala Thr Arg Val Gln Ala His 10 15 20 cct gta gca gtt aat gcg aac tcc tct cag acc aag cct tca aag aag 211 Pro Val Ala Val Asn Ala Asn Ser Ser Gln Thr Lys Pro Ser Lys Lys 25 30 35 att gtc gcc gaa ggt ggc gga agc gtt aag cgt ccc ggc gat cgc atc 259 Ile Val Ala Glu Gly Gly Gly Ser Val Lys Arg Pro Gly Asp Arg Ile 40 45 50 ttc gaa gtc cta tcc acc gct tct gca gca atc att act gcg ata atc 307 Phe Glu Val Leu Ser Thr Ala Ser Ala Ala Ile Ile Thr Ala Ile Ile 55 60 65 att gcc att gcg gcg ttc ctt atc tgg cgt gct gtt ccc gcc ttg atg 355 Ile Ala Ile Ala Ala Phe Leu Ile Trp Arg Ala Val Pro Ala Leu Met 70 75 80 85 cga aat gct gaa ggt att ggc gga ttc ttc act tat tca ggc gct tgg 403 Arg Asn Ala Glu Gly Ile Gly Gly Phe Phe Thr Tyr Ser Gly Ala Trp 90 95 100 aac acc acc gac att gat gca atg tac ttc ggt att cca aac ctg cta 451 Asn Thr Thr Asp Ile Asp Ala Met Tyr Phe Gly Ile Pro Asn Leu Leu 105 110 115 gct gca aca ctt ctc atc tct gtc atc gca ctg atc atc gcc atg ccg 499 Ala Ala Thr Leu Leu Ile Ser Val Ile Ala Leu Ile Ile Ala Met Pro 120 125 130 att gct ctt ggt att gcg atc ttc ttg tcc aac tac tca cca aag cgc 547 Ile Ala Leu Gly Ile Ala Ile Phe Leu Ser Asn Tyr Ser Pro Lys Arg 135 140 145 ctg gtt aag cca ctt ggc tac atg gtg gac atg ctg gct gct gtg cct 595 Leu Val Lys Pro Leu Gly Tyr Met Val Asp Met Leu Ala Ala Val Pro 150 155 160 165 tcc atc gtc tac ggc ctt tgg ggc tgg cag gtg ctc gga cca gct ctg 643 Ser Ile Val Tyr Gly Leu Trp Gly Trp Gln Val Leu Gly Pro Ala Leu 170 175 180 tcc ggt ttc tac acc tgg att gaa agc tgg ggc gga agc ttc ttc ctc 691 Ser Gly Phe Tyr Thr Trp Ile Glu Ser Trp Gly Gly Ser Phe Phe Leu 185 190 195 ttc gct act tac caa aac tca cct tct ttt gct acc ggc cgt aac atg 739 Phe Ala Thr Tyr Gln Asn Ser Pro Ser Phe Ala Thr Gly Arg Asn Met 200 205 210 ctc acc ggt ggc atc gtg ctc gca gtg atg atc ctt cct gtt atc gca 787 Leu Thr Gly Gly Ile Val Leu Ala Val Met Ile Leu Pro Val Ile Ala 215 220 225 gca acc gca cgt gaa gtt ttc ata cag act cca aag ggc cac att gaa 835 Ala Thr Ala Arg Glu Val Phe Ile Gln Thr Pro Lys Gly His Ile Glu 230 235 240 245 tct gct ctt gca ctt ggc gca acc cgc tgg gaa gtc gtt cgt ttg acg 883 Ser Ala Leu Ala Leu Gly Ala Thr Arg Trp Glu Val Val Arg Leu Thr 250 255 260 gtt ctc cca ttc gga atg tcc ggc tac gtt tcc ggc gcg atg ctc ggc 931 Val Leu Pro Phe Gly Met Ser Gly Tyr Val Ser Gly Ala Met Leu Gly 265 270 275 ctc ggc cgc gca ctg ggt gag acc atg gcg cta tac atg gtt gtt tct 979 Leu Gly Arg Ala Leu Gly Glu Thr Met Ala Leu Tyr Met Val Val Ser 280 285 290 cca tcc tcg gcg ttc cgc ttc tcg ctt ttc gat ggc ggt acc acc ttc 1027 Pro Ser Ser Ala Phe Arg Phe Ser Leu Phe Asp Gly Gly Thr Thr Phe 295 300 305 gca acg gcc atc gcc aat gcc gct cca gaa ttc aac gac aac acc cgc 1075 Ala Thr Ala Ile Ala Asn Ala Ala Pro Glu Phe Asn Asp Asn Thr Arg 310 315 320 325 gca ggc gcg tac atc tcc gcc ggc ctc gtg ctg ttc gcc ctt acc ttc 1123 Ala Gly Ala Tyr Ile Ser Ala Gly Leu Val Leu Phe Ala Leu Thr Phe 330 335 340 atc gtc aac gct ggc gct cgc gcc atg gtt aac cgc gga aag 1165 Ile Val Asn Ala Gly Ala Arg Ala Met Val Asn Arg Gly Lys 345 350 355 tagaagggga caaaatcatg actaacaatg 1195 <210> 48 <211> 355 <212> PRT <213> Corynebacterium glutamicum <400> 48 Met Ala Thr Asn Glu Ser Val Ser Glu Lys Gln Arg Leu Asp Ala Thr 1 5 10 15 Arg Val Gln Ala His Pro Val Ala Val Asn Ala Asn Ser Ser Gln Thr 20 25 30 Lys Pro Ser Lys Lys Ile Val Ala Glu Gly Gly Gly Ser Val Lys Arg 35 40 45 Pro Gly Asp Arg Ile Phe Glu Val Leu Ser Thr Ala Ser Ala Ala Ile 50 55 60 Ile Thr Ala Ile Ile Ile Ala Ile Ala Ala Phe Leu Ile Trp Arg Ala 65 70 75 80 Val Pro Ala Leu Met Arg Asn Ala Glu Gly Ile Gly Gly Phe Phe Thr 85 90 95 Tyr Ser Gly Ala Trp Asn Thr Thr Asp Ile Asp Ala Met Tyr Phe Gly 100 105 110 Ile Pro Asn Leu Leu Ala Ala Thr Leu Leu Ile Ser Val Ile Ala Leu 115 120 125 Ile Ile Ala Met Pro Ile Ala Leu Gly Ile Ala Ile Phe Leu Ser Asn 130 135 140 Tyr Ser Pro Lys Arg Leu Val Lys Pro Leu Gly Tyr Met Val Asp Met 145 150 155 160 Leu Ala Ala Val Pro Ser Ile Val Tyr Gly Leu Trp Gly Trp Gln Val 165 170 175 Leu Gly Pro Ala Leu Ser Gly Phe Tyr Thr Trp Ile Glu Ser Trp Gly 180 185 190 Gly Ser Phe Phe Leu Phe Ala Thr Tyr Gln Asn Ser Pro Ser Phe Ala 195 200 205 Thr Gly Arg Asn Met Leu Thr Gly Gly Ile Val Leu Ala Val Met Ile 210 215 220 Leu Pro Val Ile Ala Ala Thr Ala Arg Glu Val Phe Ile Gln Thr Pro 225 230 235 240 Lys Gly His Ile Glu Ser Ala Leu Ala Leu Gly Ala Thr Arg Trp Glu 245 250 255 Val Val Arg Leu Thr Val Leu Pro Phe Gly Met Ser Gly Tyr Val Ser 260 265 270 Gly Ala Met Leu Gly Leu Gly Arg Ala Leu Gly Glu Thr Met Ala Leu 275 280 285 Tyr Met Val Val Ser Pro Ser Ser Ala Phe Arg Phe Ser Leu Phe Asp 290 295 300 Gly Gly Thr Thr Phe Ala Thr Ala Ile Ala Asn Ala Ala Pro Glu Phe 305 310 315 320 Asn Asp Asn Thr Arg Ala Gly Ala Tyr Ile Ser Ala Gly Leu Val Leu 325 330 335 Phe Ala Leu Thr Phe Ile Val Asn Ala Gly Ala Arg Ala Met Val Asn 340 345 350 Arg Gly Lys 355 <210> 49 <211> 1327 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1297) <223> RXA00792 <400> 49 cacctttggt gctgagccag gccacccagg cctttgaggt tggcgcagat gccttaaacg 60 gcggccacgt ggctgcccaa tacacgatcg gatccttgtc atg agc caa gaa att 115 Met Ser Gln Glu Ile 1 5 ttg agc cat ttt gca ccc gca tta gag cgc att cga agc ggc gcc gtc 163 Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile Arg Ser Gly Ala Val 10 15 20 gag cgc gaa cag cag cgc gcc ttg cca gtg gaa gag att aaa gag ctg 211 Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu Glu Ile Lys Glu Leu 25 30 35 gta gag cta ggt ttt act ggg ctt cga gtg ccc gaa gaa cta ggc ggt 259 Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro Glu Glu Leu Gly Gly 40 45 50 gcg ggc gct tcc ctg gaa agc gta gtt gag tta ctg atc gag atc gcg 307 Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu Leu Ile Glu Ile Ala 55 60 65 ggc gcc gat tcc aat atc gcc caa gcc ctg cgc gga cat ttt gcc ttc 355 Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg Gly His Phe Ala Phe 70 75 80 85 gtg gaa cta ctc ctg gaa gcg ccg gag agc gaa ttc cgc acc cat tgg 403 Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu Phe Arg Thr His Trp 90 95 100 ctg cgc gaa gtc gcc acc gga aga ctt gtg ggc aac gcc gaa agt gag 451 Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly Asn Ala Glu Ser Glu 105 110 115 aaa cgc ggc gtt tac ggc gat ccg cag acc ttc atc gat gag gtg gag 499 Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe Ile Asp Glu Val Glu 120 125 130 act gaa aac gga ccg att ttc gtg ctc aac ggc act aag ttt tat acc 547 Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly Thr Lys Phe Tyr Thr 135 140 145 acc ggc acc tat ttt gcg gac tac acc tgg acc acc gcg ctg ctg cgc 595 Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr Thr Ala Leu Leu Arg 150 155 160 165 aac ctc aac ggc caa gaa act ttg gtc agt ttg ccg gtc gat ctg cac 643 Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu Pro Val Asp Leu His 170 175 180 gcg ccg ggc gtg gat gtt gct gat gat tgg agc ggg ttt ggg caa aag 691 Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser Gly Phe Gly Gln Lys 185 190 195 ctc acc gcc tct gga acg acc acg ttt aaa gac ctg gag gtg gat ccg 739 Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp Leu Glu Val Asp Pro 200 205 210 cgg tgg atc att cca cgc act gat gcg ccc acg ctg gtg tgg acg tat 787 Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr Leu Val Trp Thr Tyr 215 220 225 ctg cag ctg agc ctg ctg acc gtg ctg gtt ggc agt gcc gca gca gct 835 Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly Ser Ala Ala Ala Ala 230 235 240 245 gtc gat gag gtg gtt gcc cgc gcc caa tcc tcc acc aga aat gcg tgg 883 Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser Thr Arg Asn Ala Trp 250 255 260 aac cct ggc gtc gag cgc cgc agc gat ccg gcc gca acc ata gcg atc 931 Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala Ala Thr Ile Ala Ile 265 270 275 ggc gac gca cgc agc cga gtc acc gtt att cgt gga gcg ctt ctc gac 979 Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg Gly Ala Leu Leu Asp 280 285 290 gcc acc cgc cac gtt tcc aac gcc gcc acg atc gta acc ccc gaa gcc 1027 Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile Val Thr Pro Glu Ala 295 300 305 ttc aac gag gcg gac gct att gtt gca gcg ctc tgg ccc atc gtc tcc 1075 Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu Trp Pro Ile Val Ser 310 315 320 325 gga caa gct ttg gtg gtg aca tcc aac gtt ttc gat gcg gtg ggt gca 1123 Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe Asp Ala Val Gly Ala 330 335 340 tct gca gtg ctt ggt gag cat tcc att gat cgc cac tgg cgc aat gtg 1171 Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg His Trp Arg Asn Val 345 350 355 cgt acc gtg tcc tca aac aac ccg gtg ttc ctg gcc aag aat gca gtg 1219 Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu Ala Lys Asn Ala Val 360 365 370 ggg gag tat gcc ctc aac ggc act cct gtg ggt acc aac att ggt aaa 1267 Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly Thr Asn Ile Gly Lys 375 380 385 gca ctg agc cgt ccg gtg agc cta agc agc tagacgtgtg atttcgctgg 1317 Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 390 395 tttttagatg 1327 <210> 50 <211> 399 <212> PRT <213> Corynebacterium glutamicum <400> 50 Met Ser Gln Glu Ile Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile 1 5 10 15 Arg Ser Gly Ala Val Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu 20 25 30 Glu Ile Lys Glu Leu Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro 35 40 45 Glu Glu Leu Gly Gly Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu 50 55 60 Leu Ile Glu Ile Ala Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg 65 70 75 80 Gly His Phe Ala Phe Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu 85 90 95 Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly 100 105 110 Asn Ala Glu Ser Glu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe 115 120 125 Ile Asp Glu Val Glu Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly 130 135 140 Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr 145 150 155 160 Thr Ala Leu Leu Arg Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu 165 170 175 Pro Val Asp Leu His Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser 180 185 190 Gly Phe Gly Gln Lys Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp 195 200 205 Leu Glu Val Asp Pro Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr 210 215 220 Leu Val Trp Thr Tyr Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly 225 230 235 240 Ser Ala Ala Ala Ala Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser 245 250 255 Thr Arg Asn Ala Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala 260 265 270 Ala Thr Ile Ala Ile Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg 275 280 285 Gly Ala Leu Leu Asp Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile 290 295 300 Val Thr Pro Glu Ala Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu 305 310 315 320 Trp Pro Ile Val Ser Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe 325 330 335 Asp Ala Val Gly Ala Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg 340 345 350 His Trp Arg Asn Val Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu 355 360 365 Ala Lys Asn Ala Val Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly 370 375 380 Thr Asn Ile Gly Lys Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 385 390 395 <210> 51 <211> 1324 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1294) <223> RXA00819 <400> 51 gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60 agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115 Met Arg Asp Pro Ile 1 5 caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163 Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu 10 15 20 acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211 Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu 25 30 35 gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259 Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe 40 45 50 ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307 Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro 55 60 65 cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly 70 75 80 85 ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat gtt ggt acc tat 403 Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn Val Gly Thr Tyr 90 95 100 tac aac gca tct gct ggt ctc ttc cga acg gcc tgc atg gtt ggt ggc 451 Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala Cys Met Val Gly Gly 105 110 115 tcc ccg gag cag gcg cag cga ttg gat gcg cag atc aaa tct ggt gag 499 Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile Lys Ser Gly Glu 120 125 130 gtc aag ggc gtt ttt gca ctg acg gaa cct gat cat ggc tct gat atc 547 Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His Gly Ser Asp Ile 135 140 145 gca ggt ggt ctg gca acc acg gcc act aag gac gca gac acc ggc gag 595 Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala Asp Thr Gly Glu 150 155 160 165 tgg att atc aat ggt gaa aaa cgg tgg atc ggt ggt gct tcc act gct 643 Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly Ala Ser Thr Ala 170 175 180 gat ttg atc gct acc ttc gcc agg gat aca gcc gat aac cag gtg aaa 691 Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp Asn Gln Val Lys 185 190 195 tgc ttc ctc gtg gca cct cag gca gag ggc gtg tcc atg gag att att 739 Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser Met Glu Ile Ile 200 205 210 gat cgc aaa gcc tca ctg cgc atc atg caa aat gca cac att acc tat 787 Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala His Ile Thr Tyr 215 220 225 aac aat gtc cgg gtg tct ggg gat gcg cgg ctg cac aac atc aat tct 835 Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His Asn Ile Asn Ser 230 235 240 245 ttc aag gat gtt tcg gaa tgc ctg cgc cgt atg cgt tcc gat gtg gcg 883 Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg Ser Asp Val Ala 250 255 260 tgg atg gcg gtc ggt gcg cag gca ggt gcc tat gaa gca gcc gtg aag 931 Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu Ala Ala Val Lys 265 270 275 tat gtg cgc agc agg gaa cag ttt ggc cgt ccg atc gcg ggg ttc cag 979 Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile Ala Gly Phe Gln 280 285 290 ttg att cag gaa aag ctc gcg ctc atg ctg ggc aat ctc acg gcg tcg 1027 Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn Leu Thr Ala Ser 295 300 305 ctg ggc atg atg gtc aaa ctc acc gat cag cag cag gcg gga att ttc 1075 Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln Ala Gly Ile Phe 310 315 320 325 aaa gag gaa aac tcc gcg ctg gcg aaa atg ttt acc tcg ctc aaa ctt 1123 Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr Ser Leu Lys Leu 330 335 340 cgg gag acc gct agt tgg gcg cgg gaa atc tgc gga ggc aac ggc atc 1171 Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly Gly Asn Gly Ile 345 350 355 att ttg gac aac gat gtt gcc cgg ttc cat gcc gat gca gaa gcc gtc 1219 Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp Ala Glu Ala Val 360 365 370 tat tca tat gaa ggc acc cac gaa atc aat gca ctc atc gtt ggt cgc 1267 Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu Ile Val Gly Arg 375 380 385 gcc atc acg ggc gtc agc gct ttt atc taacacactt ttaaggagaa 1314 Ala Ile Thr Gly Val Ser Ala Phe Ile 390 395 catcatgact 1324 <210> 52 <211> 398 <212> PRT <213> Corynebacterium glutamicum <400> 52 Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 1 5 10 15 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr 20 25 30 Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp 35 40 45 Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu 50 55 60 Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg 65 70 75 80 Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile 85 90 95 Asn Val Gly Thr Tyr Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala 100 105 110 Cys Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln 115 120 125 Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp 130 135 140 His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp 145 150 155 160 Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly 165 170 175 Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala 180 185 190 Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val 195 200 205 Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn 210 215 220 Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu 225 230 235 240 His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met 245 250 255 Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr 260 265 270 Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro 275 280 285 Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly 290 295 300 Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln 305 310 315 320 Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe 325 330 335 Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys 340 345 350 Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala 355 360 365 Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala 370 375 380 Leu Ile Val Gly Arg Ala Ile Thr Gly Val Ser Ala Phe Ile 385 390 395 <210> 53 <211> 1180 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1150) <223> RXA00832 <400> 53 gagattgtgc taggttctga tgaggcttcg ggacgacccg aagaaatcta tgacagcctg 60 ggaacggccc agagttctta agaaagtttg actagagaac atg ccg ttt tct tgg 115 Met Pro Phe Ser Trp 1 5 cta aaa cca att gat tat gcc cgc atc ttt gtc ggc tgg gca tcg att 163 Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val Gly Trp Ala Ser Ile 10 15 20 ttt atc atc ccc ctc atc aca ctg cca tca att att gag ttg gcg ctg 211 Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile Ile Glu Leu Ala Leu 25 30 35 atc gtg gca gtc atc cta ttc tgc gca ttt ggc gtg gtg aag atg gcg 259 Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly Val Val Lys Met Ala 40 45 50 gag cgt ttg gct cat att ttg ggt gat cct ttt gga tcg ttg atc ctt 307 Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe Gly Ser Leu Ile Leu 55 60 65 acc ttg tcg atc gtg atc att gaa gtg att ttg atc tgt gcg gtg atg 355 Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu Ile Cys Ala Val Met 70 75 80 85 ctg ggg cct gct gat tca acc act gct ggt cgg gat tcc gtg atg gca 403 Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg Asp Ser Val Met Ala 90 95 100 gtg tcc atg atc atc atg ggt ttg gtc gtg gga ttg tgc cta ctc att 451 Val Ser Met Ile Ile Met Gly Leu Val Val Gly Leu Cys Leu Leu Ile 105 110 115 ggt ggt tta agg cat gga agc atg cca cac aat ggg gtg gga act ccg 499 Gly Gly Leu Arg His Gly Ser Met Pro His Asn Gly Val Gly Thr Pro 120 125 130 acc tac ttg gtg ctg atc gca act ttt tcc gta atc gcc ttt gcg gtt 547 Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val Ile Ala Phe Ala Val 135 140 145 cca gct ttc agg gga gaa tac tcc act ggg cag gca ctt gtt att tca 595 Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln Ala Leu Val Ile Ser 150 155 160 165 aca ctg aca gca gtg gtg tac ggg ttc ttc ctg ttt cgc caa atg ggt 643 Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu Phe Arg Gln Met Gly 170 175 180 gcc caa gct ggt gaa ttt caa gag gtc gag gtc gca gaa aag gca gac 691 Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val Ala Glu Lys Ala Asp 185 190 195 gac gca gca aaa tgg gag gtc cca ttt aga ggc tta atc ttg att atc 739 Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly Leu Ile Leu Ile Ile 200 205 210 act gtg ctc ccc atc gtg ttg ctg tcc cat gac atg gcc acg gtg atg 787 Thr Val Leu Pro Ile Val Leu Leu Ser His Asp Met Ala Thr Val Met 215 220 225 gat gaa gtc ctg gca agc ctt ggt gca ccc gta gca atg gct gga tta 835 Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val Ala Met Ala Gly Leu 230 235 240 245 att att gcc acc att gtc ttc ttg cca gag acc atc acc tcc ttg aaa 883 Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr Ile Thr Ser Leu Lys 250 255 260 gct gcg tgg aca gga gag att cag cga gta agc aac ctc gcg cat gga 931 Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser Asn Leu Ala His Gly 265 270 275 gcc caa gta tca acg gtg ggg ctg aca atc cca gct gtt cta gtg atc 979 Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro Ala Val Leu Val Ile 280 285 290 ggc gtg atc aca ggt caa gat gta gtt ttg ggg gag acc ccg atc aac 1027 Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly Glu Thr Pro Ile Asn 295 300 305 ttg ttg ctg ctg gga acc acc att gcg gtg aca gcc att gcg ttt agc 1075 Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr Ala Ile Ala Phe Ser 310 315 320 325 tcc aag aaa gtc agt gct gtg cat ggc tcg gtg ctg ctc atg ctt ttc 1123 Ser Lys Lys Val Ser Ala Val His Gly Ser Val Leu Leu Met Leu Phe 330 335 340 ggt gtt tac atg atg agc atg ttc gcc tgatttaggt agcctggtgg 1170 Gly Val Tyr Met Met Ser Met Phe Ala 345 350 gaatgagtgc 1180 <210> 54 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 54 Met Pro Phe Ser Trp Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val 1 5 10 15 Gly Trp Ala Ser Ile Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile 20 25 30 Ile Glu Leu Ala Leu Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly 35 40 45 Val Val Lys Met Ala Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe 50 55 60 Gly Ser Leu Ile Leu Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu 65 70 75 80 Ile Cys Ala Val Met Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg 85 90 95 Asp Ser Val Met Ala Val Ser Met Ile Ile Met Gly Leu Val Val Gly 100 105 110 Leu Cys Leu Leu Ile Gly Gly Leu Arg His Gly Ser Met Pro His Asn 115 120 125 Gly Val Gly Thr Pro Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val 130 135 140 Ile Ala Phe Ala Val Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln 145 150 155 160 Ala Leu Val Ile Ser Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu 165 170 175 Phe Arg Gln Met Gly Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val 180 185 190 Ala Glu Lys Ala Asp Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly 195 200 205 Leu Ile Leu Ile Ile Thr Val Leu Pro Ile Val Leu Leu Ser His Asp 210 215 220 Met Ala Thr Val Met Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val 225 230 235 240 Ala Met Ala Gly Leu Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr 245 250 255 Ile Thr Ser Leu Lys Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser 260 265 270 Asn Leu Ala His Gly Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro 275 280 285 Ala Val Leu Val Ile Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly 290 295 300 Glu Thr Pro Ile Asn Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr 305 310 315 320 Ala Ile Ala Phe Ser Ser Lys Lys Val Ser Ala Val His Gly Ser Val 325 330 335 Leu Leu Met Leu Phe Gly Val Tyr Met Met Ser Met Phe Ala 340 345 350 <210> 55 <211> 1987 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1957) <223> RXA00880 <400> 55 atagagaaaa attccatgtg gttaaagata tgcctaaaga tctgaccaaa aacgtgacta 60 aagacgtgac gacacaagta cagccaaatt aaaggaaagg ttg aat ttg acc atg 115 Leu Asn Leu Thr Met 1 5 act tca cct aat acc ctg cag gaa tac act gaa cct gcc aag tac acc 163 Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr Thr 10 15 20 atc gga gaa tct gaa acc tgc ctg acc gcc ctt cta gat cag att aag 211 Ile Gly Glu Ser Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile Lys 25 30 35 act cga cct tac gga gtt ttg ttc agc aag cct gcc aac tat gag tgg 259 Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu Trp 40 45 50 gtg aat gta act gcc aaa gaa ttt cag gac gag gtt ttt gcg gtt gca 307 Val Asn Val Thr Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val Ala 55 60 65 aaa gga att att tca gtc ggc gta gag cag gga gac cgt gtc gcg ctg 355 Lys Gly Ile Ile Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala Leu 70 75 80 85 ctg tcc aat act cgc tat gag tgg gct gtg ctt gat ttc gct atc tgg 403 Leu Ser Asn Thr Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile Trp 90 95 100 gcc gct ggc gca gtg agc gtg cct atc tac agc tcc tct tca ctg tcc 451 Ala Ala Gly Ala Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu Ser 105 110 115 caa att gag tgg atc att gag gat tcc ggc gct gtt ttg gcc att acc 499 Gln Ile Glu Trp Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile Thr 120 125 130 gaa acc cct gat cat acc gac ttg atg aag aac ctg gtc atc ggt gaa 547 Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn Leu Val Ile Gly Glu 135 140 145 gac gga act cca gcg att aag ggt tca cct tcc aag ctg cgc cgc att 595 Asp Gly Thr Pro Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg Ile 150 155 160 165 cta gag atc aac tct tcg gcg ttg gag acc ttg aag ttt gag ggc cgc 643 Leu Glu Ile Asn Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly Arg 170 175 180 gag ctt tct gat gag ctg gtg tgg gaa cgc att cat gca acc aag gcc 691 Glu Leu Ser Asp Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys Ala 185 190 195 gct gac ctg gcg tct ttg gtg tac acc tct ggc aca act ggt agg ccg 739 Ala Asp Leu Ala Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg Pro 200 205 210 aag ggc tgc gag ttg tcc cac tac cac tgg ttg gct gag gtc cga gcg 787 Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu Ala Glu Val Arg Ala 215 220 225 ctg atc acc aat gac atc gga gcg atc gcg atg cca ggt tca agg ttg 835 Leu Ile Thr Asn Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg Leu 230 235 240 245 ctc acc ttc ctt cct ttg gcg cac gtt ctt gct cgc gca gtg cac ttg 883 Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala Arg Ala Val His Leu 250 255 260 gcc ttc gct gtc acc ggt gca acc cag tcc cac tgg tct gat ttc agc 931 Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe Ser 265 270 275 acc ctt act ttg gaa ctg cag cgt tcc cgc ccg aac ctg att ttg ggt 979 Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu Gly 280 285 290 gtt cca cgc gtg ttt gaa aag gtc cgc aac gcc gct gct gct aat gct 1027 Val Pro Arg Val Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn Ala 295 300 305 gct gac ggt ggc gca atc aag cgc atc atg ttt gag cgt gcc gaa aag 1075 Ala Asp Gly Gly Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu Lys 310 315 320 325 gcg gcc att gaa tac tcc atg gct ctt gat act gca gaa ggc cca agc 1123 Ala Ala Ile Glu Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro Ser 330 335 340 aag tcc cag gtt atg gca cat aaa gcg ttt gac aag ctg gtg tac tcc 1171 Lys Ser Gln Val Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr Ser 345 350 355 aag atc cgt gca gct gtc ggt ggc gat gtg cag tac gcc atc acc ggt 1219 Lys Ile Arg Ala Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr Gly 360 365 370 ggt tca gcg atg ggg cag gag ctg ctg cac ttc ttc cgc ggt gtg ggc 1267 Gly Ser Ala Met Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val Gly 375 380 385 atg acc atc tac gaa ggt tat ggt ctg acg gaa tct gcg gct gct gca 1315 Met Thr Ile Tyr Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala Ala 390 395 400 405 gcg gtg gac ttc act gat caa aag atc ggc act gtg ggt aag ccg atg 1363 Ala Val Asp Phe Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro Met 410 415 420 ggt ggc atg acc atc aag atc aat gaa gat ggc gaa atc atg cta aaa 1411 Gly Gly Met Thr Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu Lys 425 430 435 ggc gag atg ttg ttc cag gga tat tgg aac aac cca gaa gcc aca gca 1459 Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr Ala 440 445 450 gaa gcc ctc cac gac ggt tgg ttc aac acc ggc gat ctg ggt gag ctg 1507 Glu Ala Leu His Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu Leu 455 460 465 ttg gag tct gga cac ctg gtg atc acc gga cgt aag aaa gat ctg atc 1555 Leu Glu Ser Gly His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu Ile 470 475 480 485 gtg acc gcg ggc ggc aag aac gtt tcc cca gga ccc atg gaa gac atc 1603 Val Thr Ala Gly Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp Ile 490 495 500 atc cgc gca cac cca ctg gtc agc cag gcc atg gtg gtg ggc gat ggt 1651 Ile Arg Ala His Pro Leu Val Ser Gln Ala Met Val Val Gly Asp Gly 505 510 515 aaa cca ttc gtt ggc ctg ctg gtg acc ttg gat cca gat atg ttg aag 1699 Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu Lys 520 525 530 cgg tgg aag ctg aac cac aac att gcg gaa tcc cgc acg gtt tct gag 1747 Arg Trp Lys Leu Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser Glu 535 540 545 att gct act gat cct gca ctg cgt gcg gaa atc cag gat gca gtc aac 1795 Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val Asn 550 555 560 565 aac gct aat gcc acg gtg tct cat tca gag gcg atc aag cgg ttc tac 1843 Asn Ala Asn Ala Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe Tyr 570 575 580 atc ctt gat cgc gac ctg acc gag gaa gcc gac gag ctg acc cca acg 1891 Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro Thr 585 590 595 ctg aag gtc aag cgc aac gtt gtt gtt cgc cgt tac gca gac gcc atc 1939 Leu Lys Val Lys Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala Ile 600 605 610 gac cac atc tac aac cga tgagtaacac agagacccaa tttgattggg 1987 Asp His Ile Tyr Asn Arg 615 <210> 56 <211> 619 <212> PRT <213> Corynebacterium glutamicum <400> 56 Leu Asn Leu Thr Met Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu 1 5 10 15 Pro Ala Lys Tyr Thr Ile Gly Glu Ser Glu Thr Cys Leu Thr Ala Leu 20 25 30 Leu Asp Gln Ile Lys Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro 35 40 45 Ala Asn Tyr Glu Trp Val Asn Val Thr Ala Lys Glu Phe Gln Asp Glu 50 55 60 Val Phe Ala Val Ala Lys Gly Ile Ile Ser Val Gly Val Glu Gln Gly 65 70 75 80 Asp Arg Val Ala Leu Leu Ser Asn Thr Arg Tyr Glu Trp Ala Val Leu 85 90 95 Asp Phe Ala Ile Trp Ala Ala Gly Ala Val Ser Val Pro Ile Tyr Ser 100 105 110 Ser Ser Ser Leu Ser Gln Ile Glu Trp Ile Ile Glu Asp Ser Gly Ala 115 120 125 Val Leu Ala Ile Thr Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn 130 135 140 Leu Val Ile Gly Glu Asp Gly Thr Pro Ala Ile Lys Gly Ser Pro Ser 145 150 155 160 Lys Leu Arg Arg Ile Leu Glu Ile Asn Ser Ser Ala Leu Glu Thr Leu 165 170 175 Lys Phe Glu Gly Arg Glu Leu Ser Asp Glu Leu Val Trp Glu Arg Ile 180 185 190 His Ala Thr Lys Ala Ala Asp Leu Ala Ser Leu Val Tyr Thr Ser Gly 195 200 205 Thr Thr Gly Arg Pro Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu 210 215 220 Ala Glu Val Arg Ala Leu Ile Thr Asn Asp Ile Gly Ala Ile Ala Met 225 230 235 240 Pro Gly Ser Arg Leu Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala 245 250 255 Arg Ala Val His Leu Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His 260 265 270 Trp Ser Asp Phe Ser Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro 275 280 285 Asn Leu Ile Leu Gly Val Pro Arg Val Phe Glu Lys Val Arg Asn Ala 290 295 300 Ala Ala Ala Asn Ala Ala Asp Gly Gly Ala Ile Lys Arg Ile Met Phe 305 310 315 320 Glu Arg Ala Glu Lys Ala Ala Ile Glu Tyr Ser Met Ala Leu Asp Thr 325 330 335 Ala Glu Gly Pro Ser Lys Ser Gln Val Met Ala His Lys Ala Phe Asp 340 345 350 Lys Leu Val Tyr Ser Lys Ile Arg Ala Ala Val Gly Gly Asp Val Gln 355 360 365 Tyr Ala Ile Thr Gly Gly Ser Ala Met Gly Gln Glu Leu Leu His Phe 370 375 380 Phe Arg Gly Val Gly Met Thr Ile Tyr Glu Gly Tyr Gly Leu Thr Glu 385 390 395 400 Ser Ala Ala Ala Ala Ala Val Asp Phe Thr Asp Gln Lys Ile Gly Thr 405 410 415 Val Gly Lys Pro Met Gly Gly Met Thr Ile Lys Ile Asn Glu Asp Gly 420 425 430 Glu Ile Met Leu Lys Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn 435 440 445 Pro Glu Ala Thr Ala Glu Ala Leu His Asp Gly Trp Phe Asn Thr Gly 450 455 460 Asp Leu Gly Glu Leu Leu Glu Ser Gly His Leu Val Ile Thr Gly Arg 465 470 475 480 Lys Lys Asp Leu Ile Val Thr Ala Gly Gly Lys Asn Val Ser Pro Gly 485 490 495 Pro Met Glu Asp Ile Ile Arg Ala His Pro Leu Val Ser Gln Ala Met 500 505 510 Val Val Gly Asp Gly Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp 515 520 525 Pro Asp Met Leu Lys Arg Trp Lys Leu Asn His Asn Ile Ala Glu Ser 530 535 540 Arg Thr Val Ser Glu Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu Ile 545 550 555 560 Gln Asp Ala Val Asn Asn Ala Asn Ala Thr Val Ser His Ser Glu Ala 565 570 575 Ile Lys Arg Phe Tyr Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala Asp 580 585 590 Glu Leu Thr Pro Thr Leu Lys Val Lys Arg Asn Val Val Val Arg Arg 595 600 605 Tyr Ala Asp Ala Ile Asp His Ile Tyr Asn Arg 610 615 <210> 57 <211> 976 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(946) <223> RXA00931 <400> 57 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60 gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115 Val Lys Thr Ile Glu 1 5 gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163 Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro 10 15 20 gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211 Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala 25 30 35 caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259 Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val 40 45 50 cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307 His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro 55 60 65 gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355 Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr 70 75 80 85 cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403 Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln 90 95 100 gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451 Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met 105 110 115 cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499 Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met 120 125 130 ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547 Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile 135 140 145 cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595 Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr 150 155 160 165 gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643 Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro 170 175 180 acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691 Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu 185 190 195 cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739 His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser 200 205 210 ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787 Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp 215 220 225 ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835 Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu 230 235 240 245 act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883 Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val 250 255 260 aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931 Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile 265 270 275 ccg atg cgc aaa gac taaaatgcag cgaacttgaa gatctgaatc 976 Pro Met Arg Lys Asp 280 <210> 58 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 58 Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp 1 5 10 15 Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly 20 25 30 Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp 35 40 45 Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly 50 55 60 Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly 65 70 75 80 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val 85 90 95 Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu 100 105 110 His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly 115 120 125 Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp 130 135 140 Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser 145 150 155 160 Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser 180 185 190 Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys 195 200 205 Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe 210 215 220 Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp 245 250 255 Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu 260 265 270 Gly Ala Gln Ser Ile Pro Met Arg Lys Asp 275 280 <210> 59 <211> 2005 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1975) <223> RXA00939 <400> 59 gtgtgggtga ttgatccagg tcaaggaagt ttctccggaa ttgtcctaac ttaatgagtg 60 tcacaagaaa aagaccctca aaaagtaaag gacacccatc atg aag acc tgg aaa 115 Met Lys Thr Trp Lys 1 5 acc tgg ggc atc gtc gcc gtc tca ggc ctg ttg att atc ctg tcc tgg 163 Thr Trp Gly Ile Val Ala Val Ser Gly Leu Leu Ile Ile Leu Ser Trp 10 15 20 ctc acc ccc gct ggg tgg ctg tca gac gga ttc atg atc gcc gcc gcg 211 Leu Thr Pro Ala Gly Trp Leu Ser Asp Gly Phe Met Ile Ala Ala Ala 25 30 35 gtg gtc gcc ggc tgg cag atc gcc ctc tcc gcc gtc cag gcc ctg cgc 259 Val Val Ala Gly Trp Gln Ile Ala Leu Ser Ala Val Gln Ala Leu Arg 40 45 50 att agg atg atc tcg att gac ctg ctg gtc atc gtc gcc gcc atc ggc 307 Ile Arg Met Ile Ser Ile Asp Leu Leu Val Ile Val Ala Ala Ile Gly 55 60 65 gcg ctg ttc atc aac aac tac tgg gaa tcc gcc gcc gtc acc ttc ctc 355 Ala Leu Phe Ile Asn Asn Tyr Trp Glu Ser Ala Ala Val Thr Phe Leu 70 75 80 85 ttc gcc ctc ggc aag gca ctg gag aag gcc acg atg aac cgc acc cgc 403 Phe Ala Leu Gly Lys Ala Leu Glu Lys Ala Thr Met Asn Arg Thr Arg 90 95 100 aag gca ctg tct gac ctg gtg gac gct gcc ccc gag acc gcc acc gtg 451 Lys Ala Leu Ser Asp Leu Val Asp Ala Ala Pro Glu Thr Ala Thr Val 105 110 115 ctg cgc gac ggt gag ccc gaa acc gtt gag atc tgg gaa ctg gcc ccc 499 Leu Arg Asp Gly Glu Pro Glu Thr Val Glu Ile Trp Glu Leu Ala Pro 120 125 130 ggt gac gtc gtg ctc gtg aaa aac ggc gag cag atc ccc gtc gat gga 547 Gly Asp Val Val Leu Val Lys Asn Gly Glu Gln Ile Pro Val Asp Gly 135 140 145 cgc gtg ctc tcc gga cac ggt ggg gtc gat gag gcc acc atc acc gga 595 Arg Val Leu Ser Gly His Gly Gly Val Asp Glu Ala Thr Ile Thr Gly 150 155 160 165 gaa tcc gtc ccg gcc gag aag gcc gcg gac tcc gag gtc ttc gcc ggc 643 Glu Ser Val Pro Ala Glu Lys Ala Ala Asp Ser Glu Val Phe Ala Gly 170 175 180 acc tgg ctg cgc tcc ggt gtg ctg cgc att gag gcg atc ggc atc ggc 691 Thr Trp Leu Arg Ser Gly Val Leu Arg Ile Glu Ala Ile Gly Ile Gly 185 190 195 tcg gat tcc acc ctg gcc aag atc atc cac cgt gtc gaa gac gcc cag 739 Ser Asp Ser Thr Leu Ala Lys Ile Ile His Arg Val Glu Asp Ala Gln 200 205 210 gat gac aag gca aaa acc cag acg ttc ctg gag aaa ttc tcg aag tac 787 Asp Asp Lys Ala Lys Thr Gln Thr Phe Leu Glu Lys Phe Ser Lys Tyr 215 220 225 tac acc ccc ggc gtc atg atc gcc gcc ctg gcc gtc ggc ctg atc acc 835 Tyr Thr Pro Gly Val Met Ile Ala Ala Leu Ala Val Gly Leu Ile Thr 230 235 240 245 ctg aac gtt gaa ctg gcc ctg acc ctg ctg gtc atc gcc tgc ccg ggt 883 Leu Asn Val Glu Leu Ala Leu Thr Leu Leu Val Ile Ala Cys Pro Gly 250 255 260 gcc ctg gtc atc tcg atc ccg gtc tcg atc gtc gcc ggt atc ggc cgc 931 Ala Leu Val Ile Ser Ile Pro Val Ser Ile Val Ala Gly Ile Gly Arg 265 270 275 tcc gcc aag gac ggc gtc ctg atc aag ggc ggg gaa tac ctg gag acc 979 Ser Ala Lys Asp Gly Val Leu Ile Lys Gly Gly Glu Tyr Leu Glu Thr 280 285 290 tcc gcg aag gtc gac acc gta gtc gtc gac aag acc ggc acc ctg acc 1027 Ser Ala Lys Val Asp Thr Val Val Val Asp Lys Thr Gly Thr Leu Thr 295 300 305 aac ggc cgc ccc gag ctg acc aac gtc gac gtc ctt gac ccc gcc tac 1075 Asn Gly Arg Pro Glu Leu Thr Asn Val Asp Val Leu Asp Pro Ala Tyr 310 315 320 325 tcg gac gat gag gtg ctc acc ctg gcc gcc cgc gcg gaa acc gcc tcc 1123 Ser Asp Asp Glu Val Leu Thr Leu Ala Ala Arg Ala Glu Thr Ala Ser 330 335 340 gag cac ccc ctg gcc gag gcc atc atc cgc ggc gcg gag aac agg ggc 1171 Glu His Pro Leu Ala Glu Ala Ile Ile Arg Gly Ala Glu Asn Arg Gly 345 350 355 ttg acc gtg gcg atg gta gaa aag gcc gaa ccg gtc gcc ggc cgc ggc 1219 Leu Thr Val Ala Met Val Glu Lys Ala Glu Pro Val Ala Gly Arg Gly 360 365 370 atc cgc gct gac gtg gac ggt gcc acc gtg gcc gtg ggc tca gcc gac 1267 Ile Arg Ala Asp Val Asp Gly Ala Thr Val Ala Val Gly Ser Ala Asp 375 380 385 ctg ctc gat cac acc ccg gat aac acc cgc att ctc gag ctc aac gaa 1315 Leu Leu Asp His Thr Pro Asp Asn Thr Arg Ile Leu Glu Leu Asn Glu 390 395 400 405 cag ggc agg acc gcc atg tac gtc ggc atc aac ggc aag gcc gtg ggc 1363 Gln Gly Arg Thr Ala Met Tyr Val Gly Ile Asn Gly Lys Ala Val Gly 410 415 420 atc gtc gct gtg gcc gac acc atc cga gat gat gcc ccg gcc gcg atc 1411 Ile Val Ala Val Ala Asp Thr Ile Arg Asp Asp Ala Pro Ala Ala Ile 425 430 435 agg tcc ctg cac aat aag gga atc cgc gtg gtc atg gcc acc ggt gat 1459 Arg Ser Leu His Asn Lys Gly Ile Arg Val Val Met Ala Thr Gly Asp 440 445 450 gcc gaa cgc gtc gcc cgc aac gtc gcc gcc gag ctc ggt gtc gat gag 1507 Ala Glu Arg Val Ala Arg Asn Val Ala Ala Glu Leu Gly Val Asp Glu 455 460 465 gtg agg gca gaa ctg atg cct gag gac aag ctc gag atc gtc aag gag 1555 Val Arg Ala Glu Leu Met Pro Glu Asp Lys Leu Glu Ile Val Lys Glu 470 475 480 485 ctg cag gcg cag ggc cgg gtc gtg gcc atg gtt ggc gac ggt gtc aat 1603 Leu Gln Ala Gln Gly Arg Val Val Ala Met Val Gly Asp Gly Val Asn 490 495 500 gac acc ccg gca ctg gcc acc gcg gac atc ggt gtg gcg atg ggt gcg 1651 Asp Thr Pro Ala Leu Ala Thr Ala Asp Ile Gly Val Ala Met Gly Ala 505 510 515 gcc ggt tcg cct gcc gcc atc gag acc gcc gat atc gcc ctg atg gcc 1699 Ala Gly Ser Pro Ala Ala Ile Glu Thr Ala Asp Ile Ala Leu Met Ala 520 525 530 gac aag ctg ccg cgg ctg ccc tac gcc ctg ggt ctg gcc cag cgc acg 1747 Asp Lys Leu Pro Arg Leu Pro Tyr Ala Leu Gly Leu Ala Gln Arg Thr 535 540 545 gtg cgc acc atg cgg gtc aac atc ggc atc gcc ctg ctc act gtc acg 1795 Val Arg Thr Met Arg Val Asn Ile Gly Ile Ala Leu Leu Thr Val Thr 550 555 560 565 atc ctg ctg gcc ggt gtc ctg ctc ggt gga gtg acc atg tcg att ggc 1843 Ile Leu Leu Ala Gly Val Leu Leu Gly Gly Val Thr Met Ser Ile Gly 570 575 580 atg ctc gtc cac gag gcc tcc gtc ctg ctg gtc atc gcg att gcg atg 1891 Met Leu Val His Glu Ala Ser Val Leu Leu Val Ile Ala Ile Ala Met 585 590 595 ctc ctg ctg cgc ccc acc ctg aag gaa gac aag gac aag gca gac gtc 1939 Leu Leu Leu Arg Pro Thr Leu Lys Glu Asp Lys Asp Lys Ala Asp Val 600 605 610 agt act gct gac gcc gcg aag gag acg ctg agc gcc taacgacaca 1985 Ser Thr Ala Asp Ala Ala Lys Glu Thr Leu Ser Ala 615 620 625 atcgccacag ccagccccgc 2005 <210> 60 <211> 625 <212> PRT <213> Corynebacterium glutamicum <400> 60 Met Lys Thr Trp Lys Thr Trp Gly Ile Val Ala Val Ser Gly Leu Leu 1 5 10 15 Ile Ile Leu Ser Trp Leu Thr Pro Ala Gly Trp Leu Ser Asp Gly Phe 20 25 30 Met Ile Ala Ala Ala Val Val Ala Gly Trp Gln Ile Ala Leu Ser Ala 35 40 45 Val Gln Ala Leu Arg Ile Arg Met Ile Ser Ile Asp Leu Leu Val Ile 50 55 60 Val Ala Ala Ile Gly Ala Leu Phe Ile Asn Asn Tyr Trp Glu Ser Ala 65 70 75 80 Ala Val Thr Phe Leu Phe Ala Leu Gly Lys Ala Leu Glu Lys Ala Thr 85 90 95 Met Asn Arg Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala Pro 100 105 110 Glu Thr Ala Thr Val Leu Arg Asp Gly Glu Pro Glu Thr Val Glu Ile 115 120 125 Trp Glu Leu Ala Pro Gly Asp Val Val Leu Val Lys Asn Gly Glu Gln 130 135 140 Ile Pro Val Asp Gly Arg Val Leu Ser Gly His Gly Gly Val Asp Glu 145 150 155 160 Ala Thr Ile Thr Gly Glu Ser Val Pro Ala Glu Lys Ala Ala Asp Ser 165 170 175 Glu Val Phe Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg Ile Glu 180 185 190 Ala Ile Gly Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile His Arg 195 200 205 Val Glu Asp Ala Gln Asp Asp Lys Ala Lys Thr Gln Thr Phe Leu Glu 210 215 220 Lys Phe Ser Lys Tyr Tyr Thr Pro Gly Val Met Ile Ala Ala Leu Ala 225 230 235 240 Val Gly Leu Ile Thr Leu Asn Val Glu Leu Ala Leu Thr Leu Leu Val 245 250 255 Ile Ala Cys Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser Ile Val 260 265 270 Ala Gly Ile Gly Arg Ser Ala Lys Asp Gly Val Leu Ile Lys Gly Gly 275 280 285 Glu Tyr Leu Glu Thr Ser Ala Lys Val Asp Thr Val Val Val Asp Lys 290 295 300 Thr Gly Thr Leu Thr Asn Gly Arg Pro Glu Leu Thr Asn Val Asp Val 305 310 315 320 Leu Asp Pro Ala Tyr Ser Asp Asp Glu Val Leu Thr Leu Ala Ala Arg 325 330 335 Ala Glu Thr Ala Ser Glu His Pro Leu Ala Glu Ala Ile Ile Arg Gly 340 345 350 Ala Glu Asn Arg Gly Leu Thr Val Ala Met Val Glu Lys Ala Glu Pro 355 360 365 Val Ala Gly Arg Gly Ile Arg Ala Asp Val Asp Gly Ala Thr Val Ala 370 375 380 Val Gly Ser Ala Asp Leu Leu Asp His Thr Pro Asp Asn Thr Arg Ile 385 390 395 400 Leu Glu Leu Asn Glu Gln Gly Arg Thr Ala Met Tyr Val Gly Ile Asn 405 410 415 Gly Lys Ala Val Gly Ile Val Ala Val Ala Asp Thr Ile Arg Asp Asp 420 425 430 Ala Pro Ala Ala Ile Arg Ser Leu His Asn Lys Gly Ile Arg Val Val 435 440 445 Met Ala Thr Gly Asp Ala Glu Arg Val Ala Arg Asn Val Ala Ala Glu 450 455 460 Leu Gly Val Asp Glu Val Arg Ala Glu Leu Met Pro Glu Asp Lys Leu 465 470 475 480 Glu Ile Val Lys Glu Leu Gln Ala Gln Gly Arg Val Val Ala Met Val 485 490 495 Gly Asp Gly Val Asn Asp Thr Pro Ala Leu Ala Thr Ala Asp Ile Gly 500 505 510 Val Ala Met Gly Ala Ala Gly Ser Pro Ala Ala Ile Glu Thr Ala Asp 515 520 525 Ile Ala Leu Met Ala Asp Lys Leu Pro Arg Leu Pro Tyr Ala Leu Gly 530 535 540 Leu Ala Gln Arg Thr Val Arg Thr Met Arg Val Asn Ile Gly Ile Ala 545 550 555 560 Leu Leu Thr Val Thr Ile Leu Leu Ala Gly Val Leu Leu Gly Gly Val 565 570 575 Thr Met Ser Ile Gly Met Leu Val His Glu Ala Ser Val Leu Leu Val 580 585 590 Ile Ala Ile Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu Asp Lys 595 600 605 Asp Lys Ala Asp Val Ser Thr Ala Asp Ala Ala Lys Glu Thr Leu Ser 610 615 620 Ala 625 <210> 61 <211> 1528 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1498) <223> RXA00941 <400> 61 catcgattcc gatgagattg ccacccccaa aatggggcgc ctattttttt gaccgccacc 60 cacggtagcg cttgtgcgct cagccggggt ggccgtttgc gtg tac ggg ttt tgc 115 Val Tyr Gly Phe Cys 1 5 tta tcg acg ccc act tct gat ttt aaa ggc aaa tat ttt gtg tca cag 163 Leu Ser Thr Pro Thr Ser Asp Phe Lys Gly Lys Tyr Phe Val Ser Gln 10 15 20 cga gta atc ttt tcg ggc atg aac cta acc cgg aat gac agg ctc gat 211 Arg Val Ile Phe Ser Gly Met Asn Leu Thr Arg Asn Asp Arg Leu Asp 25 30 35 cga ctg ccc gta act tcc aaa cat aaa aag att ctt ggc ggc tca ggt 259 Arg Leu Pro Val Thr Ser Lys His Lys Lys Ile Leu Gly Gly Ser Gly 40 45 50 atc ggc tgg gca ttg gat gcc atg gat gtc gga ctg atc tct ttc gtc 307 Ile Gly Trp Ala Leu Asp Ala Met Asp Val Gly Leu Ile Ser Phe Val 55 60 65 atg gct gcg ttg gcc act cat tgg ggc cta tcc cct act gaa act tcc 355 Met Ala Ala Leu Ala Thr His Trp Gly Leu Ser Pro Thr Glu Thr Ser 70 75 80 85 ctg ctc gga tcc atc ggt ttc gtt ggc atg gcc atc ggc gct tcg ctg 403 Leu Leu Gly Ser Ile Gly Phe Val Gly Met Ala Ile Gly Ala Ser Leu 90 95 100 ggc ggt ttg ctg gcg gac aag ttg ggg cgt cga caa gtt ttt gcg ttg 451 Gly Gly Leu Leu Ala Asp Lys Leu Gly Arg Arg Gln Val Phe Ala Leu 105 110 115 tct ttg cta gtt tat ggc gtt gcc act ggc gcg tcg gcg ctt tca gtg 499 Ser Leu Leu Val Tyr Gly Val Ala Thr Gly Ala Ser Ala Leu Ser Val 120 125 130 tcg ctg gca atg ttg atg gcg ctg cgc ttc gtc gtt gga ctt ggc ctg 547 Ser Leu Ala Met Leu Met Ala Leu Arg Phe Val Val Gly Leu Gly Leu 135 140 145 ggc gct gaa ctc ccc gtt gca tcc act ctg att tcc gag ttt tct cca 595 Gly Ala Glu Leu Pro Val Ala Ser Thr Leu Ile Ser Glu Phe Ser Pro 150 155 160 165 cga aaa gtt cgt ggc cgc atg gtc gtt atc ctg gag gcg ttt tgg gcg 643 Arg Lys Val Arg Gly Arg Met Val Val Ile Leu Glu Ala Phe Trp Ala 170 175 180 ctg ggc tgg atc atg gct gca atc gtc gga acc ttt gtc gtg gca gga 691 Leu Gly Trp Ile Met Ala Ala Ile Val Gly Thr Phe Val Val Ala Gly 185 190 195 tcc gat aat ggt tgg cgt tgg gcg tta gct ctt ggc tgt gtc cct gca 739 Ser Asp Asn Gly Trp Arg Trp Ala Leu Ala Leu Gly Cys Val Pro Ala 200 205 210 att tac gcg gtg tat gtc cgt ctc gga ctt cca gaa tca gta cgt ttc 787 Ile Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro Glu Ser Val Arg Phe 215 220 225 ctg gag aag aaa ggc cgg cac gac gaa gca gaa gcc atc gtt gtt tcc 835 Leu Glu Lys Lys Gly Arg His Asp Glu Ala Glu Ala Ile Val Val Ser 230 235 240 245 ttc gaa gaa gct gcc gct gcc gaa ggt aaa gct gcc gat gcc acc acc 883 Phe Glu Glu Ala Ala Ala Ala Glu Gly Lys Ala Ala Asp Ala Thr Thr 250 255 260 gct gtg gtt cat gac aac gct gcc gag ggt tcc gta tcc atc tgg tca 931 Ala Val Val His Asp Asn Ala Ala Glu Gly Ser Val Ser Ile Trp Ser 265 270 275 gct gct ttg cgc aag cgc acc gtc gcg ctg tgg atc gtg tgg ttc tgc 979 Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp Ile Val Trp Phe Cys 280 285 290 atc aac ttg tcc tac tac gga gcc ttc att tgg att cca tcg ctg ctg 1027 Ile Asn Leu Ser Tyr Tyr Gly Ala Phe Ile Trp Ile Pro Ser Leu Leu 295 300 305 gtt gcc gac ggt ttc acc ctc gtg aag tct ttc caa ttc act ctg atc 1075 Val Ala Asp Gly Phe Thr Leu Val Lys Ser Phe Gln Phe Thr Leu Ile 310 315 320 325 atc acc ttg gct cag ctt cca ggc tat gcg gtt gca gcg tgg ttg att 1123 Ile Thr Leu Ala Gln Leu Pro Gly Tyr Ala Val Ala Ala Trp Leu Ile 330 335 340 gaa aag tgg ggc cgt cgc agc aca ttg gcc acg ttc ctg gtt ggt tct 1171 Glu Lys Trp Gly Arg Arg Ser Thr Leu Ala Thr Phe Leu Val Gly Ser 345 350 355 gct atc tct gca gcg ctc tac ggc ttg gca aat gtg gag tgg cag atc 1219 Ala Ile Ser Ala Ala Leu Tyr Gly Leu Ala Asn Val Glu Trp Gln Ile 360 365 370 ctg gtc gca ggt tgt tta cta tcc ttc ttc aac ctg ggc gca tgg ggc 1267 Leu Val Ala Gly Cys Leu Leu Ser Phe Phe Asn Leu Gly Ala Trp Gly 375 380 385 gca ctg tat gcc att ggg ccg gag ctt tat ccc act aat gtc cgt gga 1315 Ala Leu Tyr Ala Ile Gly Pro Glu Leu Tyr Pro Thr Asn Val Arg Gly 390 395 400 405 act gga acg ggt gct gcc gcg gga ttc ggg cgc att gct tcc atc atc 1363 Thr Gly Thr Gly Ala Ala Ala Gly Phe Gly Arg Ile Ala Ser Ile Ile 410 415 420 gct ccg ctc att gtt ccg cca gtg att gct ttt ggt gga cca att gct 1411 Ala Pro Leu Ile Val Pro Pro Val Ile Ala Phe Gly Gly Pro Ile Ala 425 430 435 ttg ttc gct ctc ttt gcc acc gcg ttt gcg atc gca gcg att gcg gcg 1459 Leu Phe Ala Leu Phe Ala Thr Ala Phe Ala Ile Ala Ala Ile Ala Ala 440 445 450 ttt acg ctg cct gag cag aag ggt aag tct ctc gct gat tagtgagatc 1508 Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu Ala Asp 455 460 465 cttccaccag tttttcacct 1528 <210> 62 <211> 466 <212> PRT <213> Corynebacterium glutamicum <400> 62 Val Tyr Gly Phe Cys Leu Ser Thr Pro Thr Ser Asp Phe Lys Gly Lys 1 5 10 15 Tyr Phe Val Ser Gln Arg Val Ile Phe Ser Gly Met Asn Leu Thr Arg 20 25 30 Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser Lys His Lys Lys Ile 35 40 45 Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp Ala Met Asp Val Gly 50 55 60 Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr His Trp Gly Leu Ser 65 70 75 80 Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly Phe Val Gly Met Ala 85 90 95 Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp Lys Leu Gly Arg Arg 100 105 110 Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly Val Ala Thr Gly Ala 115 120 125 Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met Ala Leu Arg Phe Val 130 135 140 Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val Ala Ser Thr Leu Ile 145 150 155 160 Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg Met Val Val Ile Leu 165 170 175 Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala Ala Ile Val Gly Thr 180 185 190 Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg Trp Ala Leu Ala Leu 195 200 205 Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro 210 215 220 Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg His Asp Glu Ala Glu 225 230 235 240 Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala Ala Glu Gly Lys Ala 245 250 255 Ala Asp Ala Thr Thr Ala Val Val His Asp Asn Ala Ala Glu Gly Ser 260 265 270 Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp 275 280 285 Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr Gly Ala Phe Ile Trp 290 295 300 Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr Leu Val Lys Ser Phe 305 310 315 320 Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu Pro Gly Tyr Ala Val 325 330 335 Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg Ser Thr Leu Ala Thr 340 345 350 Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu Tyr Gly Leu Ala Asn 355 360 365 Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu Leu Ser Phe Phe Asn 370 375 380 Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly Pro Glu Leu Tyr Pro 385 390 395 400 Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala Ala Gly Phe Gly Arg 405 410 415 Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro Pro Val Ile Ala Phe 420 425 430 Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala Thr Ala Phe Ala Ile 435 440 445 Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu 450 455 460 Ala Asp 465 <210> 63 <211> 2005 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1975) <223> RXA00980 <400> 63 ggggagtggc tgtttttgga gctctttgac gcaggtcaag gaagttcaga gagcgcaacc 60 ataacgttaa aagtaaggaa aagagagaaa gggagaaatc atg aaa acg tgg aag 115 Met Lys Thr Trp Lys 1 5 acc tgg ggg gtc gtc gga gct tca ggc ctc ttg att att ttg tcg tgg 163 Thr Trp Gly Val Val Gly Ala Ser Gly Leu Leu Ile Ile Leu Ser Trp 10 15 20 ttg agt tca tcg agc ccg atg ctg gca gat gca ttc atg atc gcg gct 211 Leu Ser Ser Ser Ser Pro Met Leu Ala Asp Ala Phe Met Ile Ala Ala 25 30 35 gca att gtt gca ggt tgg ccg atc gcg cag tct gca tat caa gca ctt 259 Ala Ile Val Ala Gly Trp Pro Ile Ala Gln Ser Ala Tyr Gln Ala Leu 40 45 50 cgc att cga atg gtg tcg att gac tta ctg gtc gtt gtg gct gcc gtt 307 Arg Ile Arg Met Val Ser Ile Asp Leu Leu Val Val Val Ala Ala Val 55 60 65 ggt gcc atg ttc atc aac aac tat tgg gag tct gcg gcg gtg acg ttc 355 Gly Ala Met Phe Ile Asn Asn Tyr Trp Glu Ser Ala Ala Val Thr Phe 70 75 80 85 ctc ttt gcc ctt ggc aag gca ctg gaa cgc gcg aca atg aac cgc aca 403 Leu Phe Ala Leu Gly Lys Ala Leu Glu Arg Ala Thr Met Asn Arg Thr 90 95 100 cga aaa gca cta tcg gat ctg gtg gat gca gct cca gaa act gca aca 451 Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala Pro Glu Thr Ala Thr 105 110 115 agg ctc aac gcg gat gac tca aca gag gta gtt gag ctg tgg gag ctt 499 Arg Leu Asn Ala Asp Asp Ser Thr Glu Val Val Glu Leu Trp Glu Leu 120 125 130 gag ccc ggt gac atc gtc ttg gta cgc aat ggc gaa caa att ccc gtc 547 Glu Pro Gly Asp Ile Val Leu Val Arg Asn Gly Glu Gln Ile Pro Val 135 140 145 gat gga aac gtg att gcg ggt gtc ggt gga att gat gaa tcc aac atc 595 Asp Gly Asn Val Ile Ala Gly Val Gly Gly Ile Asp Glu Ser Asn Ile 150 155 160 165 acg ggt gaa tca atg ccg gct gaa aag ggt caa ggc tct gat gtg tat 643 Thr Gly Glu Ser Met Pro Ala Glu Lys Gly Gln Gly Ser Asp Val Tyr 170 175 180 gca gga acc tgg ctg cga tct ggt gtt ttg aga gtc gag gca aca gga 691 Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg Val Glu Ala Thr Gly 185 190 195 att ggt tca gac tca act ttg gca aaa atc att cac cgc gtt gaa gac 739 Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile His Arg Val Glu Asp 200 205 210 gcc cag gat gac aaa gcc cgc aca caa aca ttc tta gag aaa ttc tct 787 Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe Leu Glu Lys Phe Ser 215 220 225 aag tgg tac acc ccg ggc gtc atg atc gcc gcc gca gtg gtg gga ctt 835 Lys Trp Tyr Thr Pro Gly Val Met Ile Ala Ala Ala Val Val Gly Leu 230 235 240 245 atc acc tgg gac gta gaa cta gca ctg acg ctc tta gtg atc ggc tgc 883 Ile Thr Trp Asp Val Glu Leu Ala Leu Thr Leu Leu Val Ile Gly Cys 250 255 260 ccc ggc gcg ttg gtt atc tcc atc ccg gtg tcc atc gtc gca ggc atc 931 Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser Ile Val Ala Gly Ile 265 270 275 ggc cgt gct gca cgc gat ggc gtg ctg atc aag ggt gga gaa tac cta 979 Gly Arg Ala Ala Arg Asp Gly Val Leu Ile Lys Gly Gly Glu Tyr Leu 280 285 290 gaa acc gcc gcg aaa gtc gac gtc gtt gtc gtg gac aaa act gga acg 1027 Glu Thr Ala Ala Lys Val Asp Val Val Val Val Asp Lys Thr Gly Thr 295 300 305 ctg acc acc ggc cgc cca gaa ctc aca gac gta gaa gtc atc gag ccc 1075 Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val Glu Val Ile Glu Pro 310 315 320 325 gcc tac agc cag ggc gag gtg ctg gag ctc gcc gcg cgc gcc gag acg 1123 Ala Tyr Ser Gln Gly Glu Val Leu Glu Leu Ala Ala Arg Ala Glu Thr 330 335 340 gct tca gaa cat ccg ctt gcc gac gcc atc atc cgt ggt gcc cag gat 1171 Ala Ser Glu His Pro Leu Ala Asp Ala Ile Ile Arg Gly Ala Gln Asp 345 350 355 cgg ggg ctg tcc aca aca ttg gtg gaa gca gct gaa aac atc acc ggc 1219 Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Ala Glu Asn Ile Thr Gly 360 365 370 cga ggc att atc gca aat gtt gat gga cag gca gtt gct gtt gga tct 1267 Arg Gly Ile Ile Ala Asn Val Asp Gly Gln Ala Val Ala Val Gly Ser 375 380 385 gct gag tta ctt gat cat gaa cca gac tcg acc agg atc ctg gag cta 1315 Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr Arg Ile Leu Glu Leu 390 395 400 405 aat gcc gaa gga aag acc gcg atg ttt gtc gga gtg aac gga cac gcc 1363 Asn Ala Glu Gly Lys Thr Ala Met Phe Val Gly Val Asn Gly His Ala 410 415 420 att gga atc gtg gcc gtc gcc gac gcc gtt cgt tca gat tct gcc tca 1411 Ile Gly Ile Val Ala Val Ala Asp Ala Val Arg Ser Asp Ser Ala Ser 425 430 435 gca atc gaa tcg ctg cat aag gcg ggc att caa gtt gtc atg gcg act 1459 Ala Ile Glu Ser Leu His Lys Ala Gly Ile Gln Val Val Met Ala Thr 440 445 450 ggc gac gct cac cgc gtt gca caa aac gtg gcc tcc aag ctg gga gtg 1507 Gly Asp Ala His Arg Val Ala Gln Asn Val Ala Ser Lys Leu Gly Val 455 460 465 gat gaa gtc tac tca gag cta ctc cct gaa cag aaa tta gaa ctg gtg 1555 Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln Lys Leu Glu Leu Val 470 475 480 485 cgt gat ctg caa gct gcc ggc aaa acg gtc gcg atg gtg ggt gac gga 1603 Arg Asp Leu Gln Ala Ala Gly Lys Thr Val Ala Met Val Gly Asp Gly 490 495 500 gtc aac gac acc cca gca ttg gca gct gct gat atc gga gta gcg atg 1651 Val Asn Asp Thr Pro Ala Leu Ala Ala Ala Asp Ile Gly Val Ala Met 505 510 515 ggc gtg gca ggt tcc cct gca gcc att gaa acc gct gat atc gca ctc 1699 Gly Val Ala Gly Ser Pro Ala Ala Ile Glu Thr Ala Asp Ile Ala Leu 520 525 530 atg gcg gat cgt ctc cca cgg ctg gca cat gca gtg acc ttg gca aaa 1747 Met Ala Asp Arg Leu Pro Arg Leu Ala His Ala Val Thr Leu Ala Lys 535 540 545 cgc acc gta aga acc atg cgc atc aat att ctg att gcg ttg gct acc 1795 Arg Thr Val Arg Thr Met Arg Ile Asn Ile Leu Ile Ala Leu Ala Thr 550 555 560 565 gtg atg gtg tta cta gct ggc gtc cta ttt ggc gga gtt acc atg tcg 1843 Val Met Val Leu Leu Ala Gly Val Leu Phe Gly Gly Val Thr Met Ser 570 575 580 gtt ggc atg ctc gtt cac gaa gca agc gtg ctg ctt gtt atc agc atc 1891 Val Gly Met Leu Val His Glu Ala Ser Val Leu Leu Val Ile Ser Ile 585 590 595 gcc atg ctg ttg ctg cgt cca aca ctt aaa gaa gat gct gcg caa gca 1939 Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu Asp Ala Ala Gln Ala 600 605 610 agt gat att aaa cgc tcg gaa ata caa cag atc gca taaccaatgg 1985 Ser Asp Ile Lys Arg Ser Glu Ile Gln Gln Ile Ala 615 620 625 ctgggtactg atgtggtgat 2005 <210> 64 <211> 625 <212> PRT <213> Corynebacterium glutamicum <400> 64 Met Lys Thr Trp Lys Thr Trp Gly Val Val Gly Ala Ser Gly Leu Leu 1 5 10 15 Ile Ile Leu Ser Trp Leu Ser Ser Ser Ser Pro Met Leu Ala Asp Ala 20 25 30 Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp Pro Ile Ala Gln Ser 35 40 45 Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser Ile Asp Leu Leu Val 50 55 60 Val Val Ala Ala Val Gly Ala Met Phe Ile Asn Asn Tyr Trp Glu Ser 65 70 75 80 Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys Ala Leu Glu Arg Ala 85 90 95 Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala 100 105 110 Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp Ser Thr Glu Val Val 115 120 125 Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val Leu Val Arg Asn Gly 130 135 140 Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala Gly Val Gly Gly Ile 145 150 155 160 Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro Ala Glu Lys Gly Gln 165 170 175 Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg 180 185 190 Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile 195 200 205 His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe 210 215 220 Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly Val Met Ile Ala Ala 225 230 235 240 Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu Leu Ala Leu Thr Leu 245 250 255 Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser 260 265 270 Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp Gly Val Leu Ile Lys 275 280 285 Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val Asp Val Val Val Val 290 295 300 Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val 305 310 315 320 Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu Val Leu Glu Leu Ala 325 330 335 Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu Ala Asp Ala Ile Ile 340 345 350 Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Ala 355 360 365 Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn Val Asp Gly Gln Ala 370 375 380 Val Ala Val Gly Ser Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr 385 390 395 400 Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr Ala Met Phe Val Gly 405 410 415 Val Asn Gly His Ala Ile Gly Ile Val Ala Val Ala Asp Ala Val Arg 420 425 430 Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His Lys Ala Gly Ile Gln 435 440 445 Val Val Met Ala Thr Gly Asp Ala His Arg Val Ala Gln Asn Val Ala 450 455 460 Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln 465 470 475 480 Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala Gly Lys Thr Val Ala 485 490 495 Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala Leu Ala Ala Ala Asp 500 505 510 Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro Ala Ala Ile Glu Thr 515 520 525 Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro Arg Leu Ala His Ala 530 535 540 Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met Arg Ile Asn Ile Leu 545 550 555 560 Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala Gly Val Leu Phe Gly 565 570 575 Gly Val Thr Met Ser Val Gly Met Leu Val His Glu Ala Ser Val Leu 580 585 590 Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu 595 600 605 Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser Glu Ile Gln Gln Ile 610 615 620 Ala 625 <210> 65 <211> 1012 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(982) <223> RXA01013 <400> 65 tgatcgcagc tgctgtttat gttttgatca acctcatcgt ggatttgttg tacccagtcc 60 tcgatgcccg tctgcgccgc agggaaaggg cataagactc atg agt aat cct cct 115 Met Ser Asn Pro Pro 1 5 att tca ccc aaa aaa ccg gta tcc gct aat cct cga act gga tcc gct 163 Ile Ser Pro Lys Lys Pro Val Ser Ala Asn Pro Arg Thr Gly Ser Ala 10 15 20 gac ccg gca cgc aag cgt aaa gcg ttg ggc aat cct tgg acg agg cct 211 Asp Pro Ala Arg Lys Arg Lys Ala Leu Gly Asn Pro Trp Thr Arg Pro 25 30 35 gct gct gtt att tcc atc gtg gta ctc gcc gtt gcg gtg ctg atg gca 259 Ala Ala Val Ile Ser Ile Val Val Leu Ala Val Ala Val Leu Met Ala 40 45 50 ctt gtt cct gga ctg ttt acc tcc cag gat ccg ttc act ggc gat gat 307 Leu Val Pro Gly Leu Phe Thr Ser Gln Asp Pro Phe Thr Gly Asp Asp 55 60 65 gtg gcg ctg ctt ggg cca agt ggc acc cac tgg ttt ggt acc gat tcc 355 Val Ala Leu Leu Gly Pro Ser Gly Thr His Trp Phe Gly Thr Asp Ser 70 75 80 85 gtg gga cgc gat ctc tac agt cgt gtt gtt tac ggc gcg agg gaa acc 403 Val Gly Arg Asp Leu Tyr Ser Arg Val Val Tyr Gly Ala Arg Glu Thr 90 95 100 ctg ctc ggt gca ctg atc gca gtg ctg gtt ggt ctg atc gtg gga acc 451 Leu Leu Gly Ala Leu Ile Ala Val Leu Val Gly Leu Ile Val Gly Thr 105 110 115 ctg atc gga ctg ctc gca ggt gca cag cgc ggt tgg gtt gac act gta 499 Leu Ile Gly Leu Leu Ala Gly Ala Gln Arg Gly Trp Val Asp Thr Val 120 125 130 tta atg cgt ttc gtg gat gtg ctg ttg tcc atc ccg gca ctg ctg ctc 547 Leu Met Arg Phe Val Asp Val Leu Leu Ser Ile Pro Ala Leu Leu Leu 135 140 145 agc ttg act gtc att atc ctt ttg gga ttc ggc acc atg aac gca gcg 595 Ser Leu Thr Val Ile Ile Leu Leu Gly Phe Gly Thr Met Asn Ala Ala 150 155 160 165 atc gca gtc ggt att acc tct gtt gcc acc ttc gcg cgt ctg gcg cgt 643 Ile Ala Val Gly Ile Thr Ser Val Ala Thr Phe Ala Arg Leu Ala Arg 170 175 180 tcc cag gtg atg act gtt gca ggt tcc gat ttc gtg gaa gct gca tac 691 Ser Gln Val Met Thr Val Ala Gly Ser Asp Phe Val Glu Ala Ala Tyr 185 190 195 ggt tcc ggt ggc acc cag gcg cag gtg ttg ttc cgc cac att ctg cct 739 Gly Ser Gly Gly Thr Gln Ala Gln Val Leu Phe Arg His Ile Leu Pro 200 205 210 aac tct ctg acc cca gtg ttt gct ctt gca gca ctg cag ttc ggt tcc 787 Asn Ser Leu Thr Pro Val Phe Ala Leu Ala Ala Leu Gln Phe Gly Ser 215 220 225 gcg att ttg cag ctg tcc gtg ttg ggc ttc ttg ggc tac ggc gct ccg 835 Ala Ile Leu Gln Leu Ser Val Leu Gly Phe Leu Gly Tyr Gly Ala Pro 230 235 240 245 gca cca aca cca gag tgg ggt ctg ctg atc tct gat gcc cgc gac tac 883 Ala Pro Thr Pro Glu Trp Gly Leu Leu Ile Ser Asp Ala Arg Asp Tyr 250 255 260 atg gcg acc tca tgg tgg ctg act gtg ctg cct ggt ttt gtc atc atc 931 Met Ala Thr Ser Trp Trp Leu Thr Val Leu Pro Gly Phe Val Ile Ile 265 270 275 gcc gtg gtt atg tct gcc aac tac cta agc cgc atc att cag aag gag 979 Ala Val Val Met Ser Ala Asn Tyr Leu Ser Arg Ile Ile Gln Lys Glu 280 285 290 gca tagaaaatga ctactccctt gttagagatc 1012 Ala <210> 66 <211> 294 <212> PRT <213> Corynebacterium glutamicum <400> 66 Met Ser Asn Pro Pro Ile Ser Pro Lys Lys Pro Val Ser Ala Asn Pro 1 5 10 15 Arg Thr Gly Ser Ala Asp Pro Ala Arg Lys Arg Lys Ala Leu Gly Asn 20 25 30 Pro Trp Thr Arg Pro Ala Ala Val Ile Ser Ile Val Val Leu Ala Val 35 40 45 Ala Val Leu Met Ala Leu Val Pro Gly Leu Phe Thr Ser Gln Asp Pro 50 55 60 Phe Thr Gly Asp Asp Val Ala Leu Leu Gly Pro Ser Gly Thr His Trp 65 70 75 80 Phe Gly Thr Asp Ser Val Gly Arg Asp Leu Tyr Ser Arg Val Val Tyr 85 90 95 Gly Ala Arg Glu Thr Leu Leu Gly Ala Leu Ile Ala Val Leu Val Gly 100 105 110 Leu Ile Val Gly Thr Leu Ile Gly Leu Leu Ala Gly Ala Gln Arg Gly 115 120 125 Trp Val Asp Thr Val Leu Met Arg Phe Val Asp Val Leu Leu Ser Ile 130 135 140 Pro Ala Leu Leu Leu Ser Leu Thr Val Ile Ile Leu Leu Gly Phe Gly 145 150 155 160 Thr Met Asn Ala Ala Ile Ala Val Gly Ile Thr Ser Val Ala Thr Phe 165 170 175 Ala Arg Leu Ala Arg Ser Gln Val Met Thr Val Ala Gly Ser Asp Phe 180 185 190 Val Glu Ala Ala Tyr Gly Ser Gly Gly Thr Gln Ala Gln Val Leu Phe 195 200 205 Arg His Ile Leu Pro Asn Ser Leu Thr Pro Val Phe Ala Leu Ala Ala 210 215 220 Leu Gln Phe Gly Ser Ala Ile Leu Gln Leu Ser Val Leu Gly Phe Leu 225 230 235 240 Gly Tyr Gly Ala Pro Ala Pro Thr Pro Glu Trp Gly Leu Leu Ile Ser 245 250 255 Asp Ala Arg Asp Tyr Met Ala Thr Ser Trp Trp Leu Thr Val Leu Pro 260 265 270 Gly Phe Val Ile Ile Ala Val Val Met Ser Ala Asn Tyr Leu Ser Arg 275 280 285 Ile Ile Gln Lys Glu Ala 290 <210> 67 <211> 1516 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1486) <223> RXA01070 <400> 67 cagcttcggt taatttggtc acactaatgc aataaattcc tgtctacagc gttacagtta 60 atgaattcaa ttcaaccgct aaacgcaagg agtgctaccc atg gct aac gcc acc 115 Met Ala Asn Ala Thr 1 5 gca cag aag ggc cgt ttc ggc ctt ccc ggc tgg atg act ggc ttt ggt 163 Ala Gln Lys Gly Arg Phe Gly Leu Pro Gly Trp Met Thr Gly Phe Gly 10 15 20 gcc cag gtt atc gcc ggc ctc att ctt ggt ctt att ctc ggc ctt gtc 211 Ala Gln Val Ile Ala Gly Leu Ile Leu Gly Leu Ile Leu Gly Leu Val 25 30 35 gcc cga ggc atg gac agc ggc gct gca gac ggt gaa gca agc tgg ctt 259 Ala Arg Gly Met Asp Ser Gly Ala Ala Asp Gly Glu Ala Ser Trp Leu 40 45 50 acc ggt ctt ctt agc ggc gtc ggt tct gct tat gtt tct cta ctt aaa 307 Thr Gly Leu Leu Ser Gly Val Gly Ser Ala Tyr Val Ser Leu Leu Lys 55 60 65 gtt atg gtt cca cca ctg gtg ttc gct gca gtg gtt acc agt gtg gca 355 Val Met Val Pro Pro Leu Val Phe Ala Ala Val Val Thr Ser Val Ala 70 75 80 85 aag ttg cgc gag gta gct aac gct gct cgc ctg gct gtt tcc acc ttg 403 Lys Leu Arg Glu Val Ala Asn Ala Ala Arg Leu Ala Val Ser Thr Leu 90 95 100 gtg tgg ttc gcc att act gca ttc ttc tct gtg ctc gcg ggt atc gcc 451 Val Trp Phe Ala Ile Thr Ala Phe Phe Ser Val Leu Ala Gly Ile Ala 105 110 115 gta gcg ctg att atg cag cct ggt gtt gga tcc act gtc gac gca tct 499 Val Ala Leu Ile Met Gln Pro Gly Val Gly Ser Thr Val Asp Ala Ser 120 125 130 aat gct gct gat cct tct cgc gtg ggc agc tgg ctg ggc ttt atc cag 547 Asn Ala Ala Asp Pro Ser Arg Val Gly Ser Trp Leu Gly Phe Ile Gln 135 140 145 tcc gtt att cca tca aac att ctg gga ctt tcc ggt tct tac agt gag 595 Ser Val Ile Pro Ser Asn Ile Leu Gly Leu Ser Gly Ser Tyr Ser Glu 150 155 160 165 aac tct ggt gtg aac ctg tcc ttc aac gtg ctg cag atc ctg gtt atc 643 Asn Ser Gly Val Asn Leu Ser Phe Asn Val Leu Gln Ile Leu Val Ile 170 175 180 tcc att gcg att ggt gtt gca gct ctg aag gct ggc aag tcc gcc gag 691 Ser Ile Ala Ile Gly Val Ala Ala Leu Lys Ala Gly Lys Ser Ala Glu 185 190 195 cct ttc ttg aag ttc acc gag tcc ttc ctc aag atc atc cag atc gtg 739 Pro Phe Leu Lys Phe Thr Glu Ser Phe Leu Lys Ile Ile Gln Ile Val 200 205 210 ttg tgg tgg att att cgc ctg gct cca att ggt tcc gct gcg ctg atc 787 Leu Trp Trp Ile Ile Arg Leu Ala Pro Ile Gly Ser Ala Ala Leu Ile 215 220 225 ggt aat gct gtt gct acc tac ggt tgg tct gca ctt gga tcc ctg ggc 835 Gly Asn Ala Val Ala Thr Tyr Gly Trp Ser Ala Leu Gly Ser Leu Gly 230 235 240 245 aag ttt gtt ctt gcg atc tac gtt ggt ctg gca atc gtc atg ttc gtt 883 Lys Phe Val Leu Ala Ile Tyr Val Gly Leu Ala Ile Val Met Phe Val 250 255 260 atc tac cca gtc gtg ctg aag ctc aat gga att cct gtt ctt gga ttc 931 Ile Tyr Pro Val Val Leu Lys Leu Asn Gly Ile Pro Val Leu Gly Phe 265 270 275 ttc aag cgc gtt tgg cct gtc aca agc ctt ggc ttt gtt acc cgt tcc 979 Phe Lys Arg Val Trp Pro Val Thr Ser Leu Gly Phe Val Thr Arg Ser 280 285 290 tcc atg ggc gtt atg cca gtt acc cag cgc gtt act gag cag tcc ttg 1027 Ser Met Gly Val Met Pro Val Thr Gln Arg Val Thr Glu Gln Ser Leu 295 300 305 ggt gtt cca tct gcg tac gct tcc ttt gct atc cca ctg ggt gcg acc 1075 Gly Val Pro Ser Ala Tyr Ala Ser Phe Ala Ile Pro Leu Gly Ala Thr 310 315 320 325 agc aag atg gac ggc tgc gct gct gtc tac cca gct gtt gcc gct atc 1123 Ser Lys Met Asp Gly Cys Ala Ala Val Tyr Pro Ala Val Ala Ala Ile 330 335 340 ttc gtg gca cag ttc tac ggc att gac ttg agc atc atg gat tac gta 1171 Phe Val Ala Gln Phe Tyr Gly Ile Asp Leu Ser Ile Met Asp Tyr Val 345 350 355 ctg atc atg atc gtc tct gtc ctg ggc tct gct gca act gca ggc acc 1219 Leu Ile Met Ile Val Ser Val Leu Gly Ser Ala Ala Thr Ala Gly Thr 360 365 370 act ggc gca acc gtc atg ctg acc ctg acc cta tcc acc ttg ggt ctg 1267 Thr Gly Ala Thr Val Met Leu Thr Leu Thr Leu Ser Thr Leu Gly Leu 375 380 385 cca ctt gct ggt gtt ggt ctg ctg ctg gct atc gag cca atc atc gac 1315 Pro Leu Ala Gly Val Gly Leu Leu Leu Ala Ile Glu Pro Ile Ile Asp 390 395 400 405 atg gga cgt acc gca acc aac gtc acc ggt cag gca ctg gtt cct gcg 1363 Met Gly Arg Thr Ala Thr Asn Val Thr Gly Gln Ala Leu Val Pro Ala 410 415 420 atc gtt gct aag cgc gag ggc att ctg gat cag gat gtg tgg gat gct 1411 Ile Val Ala Lys Arg Glu Gly Ile Leu Asp Gln Asp Val Trp Asp Ala 425 430 435 gct gaa aag ggt ggc gct gct att gaa atg gca acc gtc tct gag aaa 1459 Ala Glu Lys Gly Gly Ala Ala Ile Glu Met Ala Thr Val Ser Glu Lys 440 445 450 gaa act gag cct gca gag gtt cgc tcc taagctctct tgagtacctg 1506 Glu Thr Glu Pro Ala Glu Val Arg Ser 455 460 agaccttctc 1516 <210> 68 <211> 462 <212> PRT <213> Corynebacterium glutamicum <400> 68 Met Ala Asn Ala Thr Ala Gln Lys Gly Arg Phe Gly Leu Pro Gly Trp 1 5 10 15 Met Thr Gly Phe Gly Ala Gln Val Ile Ala Gly Leu Ile Leu Gly Leu 20 25 30 Ile Leu Gly Leu Val Ala Arg Gly Met Asp Ser Gly Ala Ala Asp Gly 35 40 45 Glu Ala Ser Trp Leu Thr Gly Leu Leu Ser Gly Val Gly Ser Ala Tyr 50 55 60 Val Ser Leu Leu Lys Val Met Val Pro Pro Leu Val Phe Ala Ala Val 65 70 75 80 Val Thr Ser Val Ala Lys Leu Arg Glu Val Ala Asn Ala Ala Arg Leu 85 90 95 Ala Val Ser Thr Leu Val Trp Phe Ala Ile Thr Ala Phe Phe Ser Val 100 105 110 Leu Ala Gly Ile Ala Val Ala Leu Ile Met Gln Pro Gly Val Gly Ser 115 120 125 Thr Val Asp Ala Ser Asn Ala Ala Asp Pro Ser Arg Val Gly Ser Trp 130 135 140 Leu Gly Phe Ile Gln Ser Val Ile Pro Ser Asn Ile Leu Gly Leu Ser 145 150 155 160 Gly Ser Tyr Ser Glu Asn Ser Gly Val Asn Leu Ser Phe Asn Val Leu 165 170 175 Gln Ile Leu Val Ile Ser Ile Ala Ile Gly Val Ala Ala Leu Lys Ala 180 185 190 Gly Lys Ser Ala Glu Pro Phe Leu Lys Phe Thr Glu Ser Phe Leu Lys 195 200 205 Ile Ile Gln Ile Val Leu Trp Trp Ile Ile Arg Leu Ala Pro Ile Gly 210 215 220 Ser Ala Ala Leu Ile Gly Asn Ala Val Ala Thr Tyr Gly Trp Ser Ala 225 230 235 240 Leu Gly Ser Leu Gly Lys Phe Val Leu Ala Ile Tyr Val Gly Leu Ala 245 250 255 Ile Val Met Phe Val Ile Tyr Pro Val Val Leu Lys Leu Asn Gly Ile 260 265 270 Pro Val Leu Gly Phe Phe Lys Arg Val Trp Pro Val Thr Ser Leu Gly 275 280 285 Phe Val Thr Arg Ser Ser Met Gly Val Met Pro Val Thr Gln Arg Val 290 295 300 Thr Glu Gln Ser Leu Gly Val Pro Ser Ala Tyr Ala Ser Phe Ala Ile 305 310 315 320 Pro Leu Gly Ala Thr Ser Lys Met Asp Gly Cys Ala Ala Val Tyr Pro 325 330 335 Ala Val Ala Ala Ile Phe Val Ala Gln Phe Tyr Gly Ile Asp Leu Ser 340 345 350 Ile Met Asp Tyr Val Leu Ile Met Ile Val Ser Val Leu Gly Ser Ala 355 360 365 Ala Thr Ala Gly Thr Thr Gly Ala Thr Val Met Leu Thr Leu Thr Leu 370 375 380 Ser Thr Leu Gly Leu Pro Leu Ala Gly Val Gly Leu Leu Leu Ala Ile 385 390 395 400 Glu Pro Ile Ile Asp Met Gly Arg Thr Ala Thr Asn Val Thr Gly Gln 405 410 415 Ala Leu Val Pro Ala Ile Val Ala Lys Arg Glu Gly Ile Leu Asp Gln 420 425 430 Asp Val Trp Asp Ala Ala Glu Lys Gly Gly Ala Ala Ile Glu Met Ala 435 440 445 Thr Val Ser Glu Lys Glu Thr Glu Pro Ala Glu Val Arg Ser 450 455 460 <210> 69 <211> 1645 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1615) <223> RXA01172 <400> 69 tcgcctgaaa ggcgccagca aagctttcgc gcttggtggc taggcgcgtc gacaagcgcc 60 taaatttttc tagactaccc agattaagtg agattctttc gtg tct tcg aca act 115 Val Ser Ser Thr Thr 1 5 tcg aca act tcg gcc acc cga caa gag ccg ttg agc ccg acg ggt gtg 163 Ser Thr Thr Ser Ala Thr Arg Gln Glu Pro Leu Ser Pro Thr Gly Val 10 15 20 ctt gcc tcg ttt agg ttc gcg ttt agt agc ccg cgg agg ttt cgc acc 211 Leu Ala Ser Phe Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg Thr 25 30 35 gag gtt tta gct ggc ctc gtg gtg gcg ctc gcg ctg att ccg gag tcg 259 Glu Val Leu Ala Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu Ser 40 45 50 att gcg ttt tcc gta tta gct ggc gtg gat cct aag atg ggt ctt ttt 307 Ile Ala Phe Ser Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu Phe 55 60 65 gcg tcg tgc acc atg gca atg acc att gcg ctt aca ggt gga cgc cct 355 Ala Ser Cys Thr Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg Pro 70 75 80 85 gcg atg att tcc gcg gcg aca ggc gct gtg gcg ctg gtg att gca ccg 403 Ala Met Ile Ser Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala Pro 90 95 100 gtg gtt cgg gat cat ggc gtg gaa tat ttc ctg gcc acg gta att ttg 451 Val Val Arg Asp His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile Leu 105 110 115 gcg ggc att att cag att gcg ttg tcg ttg ctg ggt gta gcc aag ctg 499 Ala Gly Ile Ile Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys Leu 120 125 130 atg cgg ttc att ccg cgt tcc gtt atg ctc gga ttt gtt aat gcg ctg 547 Met Arg Phe Ile Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala Leu 135 140 145 gcg tgc ttg gtg ttt ttt gcg cag ctg ccg cac ctg atc gat gtt ccg 595 Ala Cys Leu Val Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val Pro 150 155 160 165 tgg atg gtg tat ccg ctg ttc gcg ctg ggt att ggc atc atg ctg ttt 643 Trp Met Val Tyr Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu Phe 170 175 180 tgg ccg aag ctg acc tcg gtg att ccg gct ccg ctg att gtt atc gtg 691 Trp Pro Lys Leu Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile Val 185 190 195 gcc ttg act gcg atc gtg tgg gtt ttc gga atc aac att cca aac gtc 739 Ala Leu Thr Ala Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn Val 200 205 210 tct gac cag ggc gaa ctc ccc tct tcc cta cca gaa ttc ctc att ccc 787 Ser Asp Gln Gly Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile Pro 215 220 225 aac gtt ccg ctt act ctt gag act cta aaa att att ggg ccg tat gcg 835 Asn Val Pro Leu Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr Ala 230 235 240 245 ctt gga atg tcg ctt gtt ggg ttg atg gaa tcg ctg ctg acc gcc aag 883 Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala Lys 250 255 260 ctg gtc gat gat att acg gag gtt cac tcc aat aaa tcc cgc gaa gct 931 Leu Val Asp Asp Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu Ala 265 270 275 gca ggt cag ggc atc gca aac att atc acc gcg ttt ttg ggc ggc atg 979 Ala Gly Gln Gly Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly Met 280 285 290 ggt ggc tgc gcg atg atc ggc cag acc atg atc aac gtg aaa aac tca 1027 Gly Gly Cys Ala Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn Ser 295 300 305 gga gcc cgc act cgc cta tcc acc ttc ttg gcc ggc ggc ttc ctg ctg 1075 Gly Ala Arg Thr Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu Leu 310 315 320 325 ctc ctg gtg gtt ttg ctg ggc gat gtc gtg ggc aaa atc ccc atg gcg 1123 Leu Leu Val Val Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met Ala 330 335 340 gcg ctc gtg gca gtc atg att atc gtc tcc atc gac acc gcc gac tgg 1171 Ala Leu Val Ala Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp Trp 345 350 355 cat tcg ctg aac ccg cgc acc ctc aaa ttc atg ccg ctg agt gaa acg 1219 His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu Thr 360 365 370 atc gtc atg ttt ata acg atc atc gcg acc ctc gtc acc gga aac ctg 1267 Ile Val Met Phe Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn Leu 375 380 385 gcg atc ggc gtc atc ctc gga gtg ctc acc gcc atg gtc atg ttt gct 1315 Ala Ile Gly Val Ile Leu Gly Val Leu Thr Ala Met Val Met Phe Ala 390 395 400 405 cgc cgc gtg gcc cac ctc gtg tct gtg gag cgc acc acc gac aac aac 1363 Arg Arg Val Ala His Leu Val Ser Val Glu Arg Thr Thr Asp Asn Asn 410 415 420 atc agc acc tat acc gtc aag ggc cag cta ttt tgg gcg tcc tcg aac 1411 Ile Ser Thr Tyr Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser Asn 425 430 435 gat atg gtg tac tcc ttc gac tac tcc gac gag gcc gag cag atc atc 1459 Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile Ile 440 445 450 atc gat ctc acc gcc gca gaa atc tgg gac gcc tcc acg gta gcc acg 1507 Ile Asp Leu Thr Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala Thr 455 460 465 ctg gac agc atc atc cac aaa tac gcc gcg cgc ggc aag agc gtg gag 1555 Leu Asp Ser Ile Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val Glu 470 475 480 485 atc atc ggg ctc gac ggc ccc agc cgc gat agg ctt gag cgc cta tca 1603 Ile Ile Gly Leu Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu Ser 490 495 500 ggc aag ctg ggc taaaaatttg cttatcgacg cgcccctcca 1645 Gly Lys Leu Gly 505 <210> 70 <211> 505 <212> PRT <213> Corynebacterium glutamicum <400> 70 Val Ser Ser Thr Thr Ser Thr Thr Ser Ala Thr Arg Gln Glu Pro Leu 1 5 10 15 Ser Pro Thr Gly Val Leu Ala Ser Phe Arg Phe Ala Phe Ser Ser Pro 20 25 30 Arg Arg Phe Arg Thr Glu Val Leu Ala Gly Leu Val Val Ala Leu Ala 35 40 45 Leu Ile Pro Glu Ser Ile Ala Phe Ser Val Leu Ala Gly Val Asp Pro 50 55 60 Lys Met Gly Leu Phe Ala Ser Cys Thr Met Ala Met Thr Ile Ala Leu 65 70 75 80 Thr Gly Gly Arg Pro Ala Met Ile Ser Ala Ala Thr Gly Ala Val Ala 85 90 95 Leu Val Ile Ala Pro Val Val Arg Asp His Gly Val Glu Tyr Phe Leu 100 105 110 Ala Thr Val Ile Leu Ala Gly Ile Ile Gln Ile Ala Leu Ser Leu Leu 115 120 125 Gly Val Ala Lys Leu Met Arg Phe Ile Pro Arg Ser Val Met Leu Gly 130 135 140 Phe Val Asn Ala Leu Ala Cys Leu Val Phe Phe Ala Gln Leu Pro His 145 150 155 160 Leu Ile Asp Val Pro Trp Met Val Tyr Pro Leu Phe Ala Leu Gly Ile 165 170 175 Gly Ile Met Leu Phe Trp Pro Lys Leu Thr Ser Val Ile Pro Ala Pro 180 185 190 Leu Ile Val Ile Val Ala Leu Thr Ala Ile Val Trp Val Phe Gly Ile 195 200 205 Asn Ile Pro Asn Val Ser Asp Gln Gly Glu Leu Pro Ser Ser Leu Pro 210 215 220 Glu Phe Leu Ile Pro Asn Val Pro Leu Thr Leu Glu Thr Leu Lys Ile 225 230 235 240 Ile Gly Pro Tyr Ala Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser 245 250 255 Leu Leu Thr Ala Lys Leu Val Asp Asp Ile Thr Glu Val His Ser Asn 260 265 270 Lys Ser Arg Glu Ala Ala Gly Gln Gly Ile Ala Asn Ile Ile Thr Ala 275 280 285 Phe Leu Gly Gly Met Gly Gly Cys Ala Met Ile Gly Gln Thr Met Ile 290 295 300 Asn Val Lys Asn Ser Gly Ala Arg Thr Arg Leu Ser Thr Phe Leu Ala 305 310 315 320 Gly Gly Phe Leu Leu Leu Leu Val Val Leu Leu Gly Asp Val Val Gly 325 330 335 Lys Ile Pro Met Ala Ala Leu Val Ala Val Met Ile Ile Val Ser Ile 340 345 350 Asp Thr Ala Asp Trp His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met 355 360 365 Pro Leu Ser Glu Thr Ile Val Met Phe Ile Thr Ile Ile Ala Thr Leu 370 375 380 Val Thr Gly Asn Leu Ala Ile Gly Val Ile Leu Gly Val Leu Thr Ala 385 390 395 400 Met Val Met Phe Ala Arg Arg Val Ala His Leu Val Ser Val Glu Arg 405 410 415 Thr Thr Asp Asn Asn Ile Ser Thr Tyr Thr Val Lys Gly Gln Leu Phe 420 425 430 Trp Ala Ser Ser Asn Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu 435 440 445 Ala Glu Gln Ile Ile Ile Asp Leu Thr Ala Ala Glu Ile Trp Asp Ala 450 455 460 Ser Thr Val Ala Thr Leu Asp Ser Ile Ile His Lys Tyr Ala Ala Arg 465 470 475 480 Gly Lys Ser Val Glu Ile Ile Gly Leu Asp Gly Pro Ser Arg Asp Arg 485 490 495 Leu Glu Arg Leu Ser Gly Lys Leu Gly 500 505 <210> 71 <211> 1207 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1177) <223> RXA01220 <400> 71 caggtgcgag catcgcgaag ttcatcgtac tcatcgctgt tgttgccttc ctgcagttta 60 ggcctcaagg actcttccaa acccaaacta ggagcctcgt atg agc act caa ctc 115 Met Ser Thr Gln Leu 1 5 aag ctg aag aag ccc gca aag aag aaa act acg ccg aaa ctt agc gtc 163 Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr Pro Lys Leu Ser Val 10 15 20 gta aat gct ccc acg ctg cgc act gcg gcg ttg ggc ctg gcc gcg ctc 211 Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu Gly Leu Ala Ala Leu 25 30 35 gct gcg gta ttg ctg tgc gcc ccg ctc ttt tta tcc aca ttc cag ctg 259 Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu Ser Thr Phe Gln Leu 40 45 50 acg ttg atg tcg cgc ttg gtg tgt tat gcg atc gtc gca gtc ggc atc 307 Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile Val Ala Val Gly Ile 55 60 65 ggg ctg gcg tgg ggc aga ggc ggc atg ctc acg ctg ggg caa ggc gtg 355 Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr Leu Gly Gln Gly Val 70 75 80 85 ttc ttt gga atc ggc gcg tac atc atg gcc atg cac atg ctg tac agc 403 Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met His Met Leu Tyr Ser 90 95 100 gat tcg cag att ttt ggg acc aca gtt ccg caa tgg tgg tcc att ttt 451 Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln Trp Trp Ser Ile Phe 105 110 115 gcc aac ccg gca gtc gca ctc atc gca gtt gtg gcg ctt ccc ggc atc 499 Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val Ala Leu Pro Gly Ile 120 125 130 gtg gct ttt gtg ctc ggc ttc tcc att ttc aaa cga cgc atc aaa ggc 547 Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys Arg Arg Ile Lys Gly 135 140 145 gcc tac ttt gcc atc gtg aac caa gcg ctc gcc gca gct gtt gtg gtg 595 Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala Ala Ala Val Val Val 150 155 160 165 ttg ctg gtc gga caa caa gat tcc ctt gga ggt tcc aat ggt ctt tcc 643 Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly Ser Asn Gly Leu Ser 170 175 180 gga ttt cga tcg ttc atg ggt ttt gcc gtc tac gac ccc atc aac cgc 691 Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr Asp Pro Ile Asn Arg 185 190 195 atc atg ttt tac ttc acc gca gtg gga gtt ctc ttg gct ttg gtg gct 739 Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu Leu Ala Leu Val Ala 200 205 210 atc tca tat tgg ctc atg cgc agc cgc tat gga gaa ctg ctc gtg gcc 787 Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly Glu Leu Leu Val Ala 215 220 225 acc aga gat gca gaa gaa cgc gtc cga ttc ctc gga tat gat ccc gca 835 Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu Gly Tyr Asp Pro Ala 230 235 240 245 ttg atc aaa acc gcc gca tat gtc att gct gcg atg att gcc gga atc 883 Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala Met Ile Ala Gly Ile 250 255 260 gcc gga gcg ctg ttc gtg ccg atc gtg ggc atc att tca ccc gca gaa 931 Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile Ile Ser Pro Ala Glu 265 270 275 atc ggc gtg gtg cca tca atc gtg ttc gtg atc gcc gtc gcc gct ggt 979 Ile Gly Val Val Pro Ser Ile Val Phe Val Ile Ala Val Ala Ala Gly 280 285 290 ggc agg gca tcc cta ttc ggt ccc gta gtt ggc gcg ctg gtg ctg ggc 1027 Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly Ala Leu Val Leu Gly 295 300 305 tgg gtg gaa tcc aca ctt gct caa act ttc ccc agc atg tgg tcc tat 1075 Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro Ser Met Trp Ser Tyr 310 315 320 325 ttc cag ggt gcg atc ctg gtt ctc gtg atc gtg ttg ctg ccg ggc gga 1123 Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val Leu Leu Pro Gly Gly 330 335 340 att gct tca att aaa ctt tcc gcg ctc aaa aat aag gcc agg aag gcc 1171 Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn Lys Ala Arg Lys Ala 345 350 355 acc tca tgagccttaa aatcaccaac ctcaaagtcg 1207 Thr Ser <210> 72 <211> 359 <212> PRT <213> Corynebacterium glutamicum <400> 72 Met Ser Thr Gln Leu Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr 1 5 10 15 Pro Lys Leu Ser Val Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu 20 25 30 Gly Leu Ala Ala Leu Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu 35 40 45 Ser Thr Phe Gln Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile 50 55 60 Val Ala Val Gly Ile Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr 65 70 75 80 Leu Gly Gln Gly Val Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met 85 90 95 His Met Leu Tyr Ser Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln 100 105 110 Trp Trp Ser Ile Phe Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val 115 120 125 Ala Leu Pro Gly Ile Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys 130 135 140 Arg Arg Ile Lys Gly Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala 145 150 155 160 Ala Ala Val Val Val Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly 165 170 175 Ser Asn Gly Leu Ser Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr 180 185 190 Asp Pro Ile Asn Arg Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu 195 200 205 Leu Ala Leu Val Ala Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly 210 215 220 Glu Leu Leu Val Ala Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu 225 230 235 240 Gly Tyr Asp Pro Ala Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala 245 250 255 Met Ile Ala Gly Ile Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile 260 265 270 Ile Ser Pro Ala Glu Ile Gly Val Val Pro Ser Ile Val Phe Val Ile 275 280 285 Ala Val Ala Ala Gly Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly 290 295 300 Ala Leu Val Leu Gly Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro 305 310 315 320 Ser Met Trp Ser Tyr Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val 325 330 335 Leu Leu Pro Gly Gly Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn 340 345 350 Lys Ala Arg Lys Ala Thr Ser 355 <210> 73 <211> 922 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(892) <223> RXA01285 <400> 73 tgtatccatc ggtggttgct acatgatctg gcttctgctg cgcgaaaccc gccgccaata 60 ccgcaccggc accatccgat agttctttta aggatccctc atg aat aac cgc ctg 115 Met Asn Asn Arg Leu 1 5 acc atg gaa gac gtc acc atg gcg tat gac aac cgc gtc atc gcc gaa 163 Thr Met Glu Asp Val Thr Met Ala Tyr Asp Asn Arg Val Ile Ala Glu 10 15 20 cac ctc aac gtc acc atc ccc gac aac acc ttc acc gcc atc atc ggc 211 His Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly 25 30 35 ccc aac ggc tgc ggc aaa tcc acc ctg ctc cgc ggt ttc tcc cgc gtg 259 Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val 40 45 50 ctc aat ccg cag cac ggc aaa gtg ctt ctc gac ggt cgg caa ctc gat 307 Leu Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp 55 60 65 tca ttc aag cct aaa gag atc gcc cga gaa cta ggc ctg ctg cca cag 355 Ser Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln 70 75 80 85 acc tcc atc gcc cca gaa ggc atc cgg gtt tac gat ctc atc gcg cgc 403 Thr Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg 90 95 100 ggg cgc gct ccc tac caa agc ctc ata caa caa tgg cgc acc tcc gac 451 Gly Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp 105 110 115 gaa gac gcc gtc gcg caa gcg ctc gcc tcc acg aat ctc acc gaa ctt 499 Glu Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu 120 125 130 gca gct cgc ctc gtc gat gaa ctc tcc ggt ggc cag cgc caa cga gtg 547 Ala Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val 135 140 145 tgg gtg gcc atg ttg ctc gcc cag caa aca ccg atc atg ctt ctc gac 595 Trp Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp 150 155 160 165 gag ccc acc acc ttc ctc gac atc gcc cac caa tac gaa ctc ttg gaa 643 Glu Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu 170 175 180 ttg ctg cgc gca ttc aac gag gcc ggg aaa act gtg gtc act gtg ctt 691 Leu Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu 185 190 195 cac gat ctc aac caa gcc gcc cgc tac gcc gac cac ctc atc gtg atg 739 His Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met 200 205 210 aaa gat ggg cac gta cat gcc acg ggc aca ccg gag gaa gtc tta act 787 Lys Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr 215 220 225 gcc gag atg gtt caa gga gtt ttt ggc ctg ccc tgc atc atc tcc cca 835 Ala Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro 230 235 240 245 gac ccc gtc aca gga acc ccc acc gtc gtt ccc ctc agt cgg tct cgc 883 Asp Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg 250 255 260 gca gga gct taagtagcta cccctccaac ggaatgatct 922 Ala Gly Ala <210> 74 <211> 264 <212> PRT <213> Corynebacterium glutamicum <400> 74 Met Asn Asn Arg Leu Thr Met Glu Asp Val Thr Met Ala Tyr Asp Asn 1 5 10 15 Arg Val Ile Ala Glu His Leu Asn Val Thr Ile Pro Asp Asn Thr Phe 20 25 30 Thr Ala Ile Ile Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg 35 40 45 Gly Phe Ser Arg Val Leu Asn Pro Gln His Gly Lys Val Leu Leu Asp 50 55 60 Gly Arg Gln Leu Asp Ser Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu 65 70 75 80 Gly Leu Leu Pro Gln Thr Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr 85 90 95 Asp Leu Ile Ala Arg Gly Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln 100 105 110 Trp Arg Thr Ser Asp Glu Asp Ala Val Ala Gln Ala Leu Ala Ser Thr 115 120 125 Asn Leu Thr Glu Leu Ala Ala Arg Leu Val Asp Glu Leu Ser Gly Gly 130 135 140 Gln Arg Gln Arg Val Trp Val Ala Met Leu Leu Ala Gln Gln Thr Pro 145 150 155 160 Ile Met Leu Leu Asp Glu Pro Thr Thr Phe Leu Asp Ile Ala His Gln 165 170 175 Tyr Glu Leu Leu Glu Leu Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr 180 185 190 Val Val Thr Val Leu His Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp 195 200 205 His Leu Ile Val Met Lys Asp Gly His Val His Ala Thr Gly Thr Pro 210 215 220 Glu Glu Val Leu Thr Ala Glu Met Val Gln Gly Val Phe Gly Leu Pro 225 230 235 240 Cys Ile Ile Ser Pro Asp Pro Val Thr Gly Thr Pro Thr Val Val Pro 245 250 255 Leu Ser Arg Ser Arg Ala Gly Ala 260 <210> 75 <211> 1060 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1030) <223> RXA01298 <400> 75 cttaaacgtc accttattta tgcattatgt tggtttcaga ctcgaacaat tcaattagaa 60 aacactaatc ggacatttag gtcacataac atttccgctc gtg tcc aca tta att 115 Val Ser Thr Leu Ile 1 5 tct gaa ccc gag gtg gat aag cta cgt aaa cgt gcc aag aga tca agg 163 Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg Ala Lys Arg Ser Arg 10 15 20 cgg aca gaa tgg tgg ctt gcc gcc gca ctt ctt gcc cca aac ttg ctt 211 Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu Ala Pro Asn Leu Leu 25 30 35 ctc ttg gcc atc ttt acg tat cgg cca ctg tta gat aac ttc cgg ttg 259 Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu Asp Asn Phe Arg Leu 40 45 50 tcc ttt ttc aac tgg aac att tcc tcg ccc aca tca acc ttc att ggg 307 Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr Ser Thr Phe Ile Gly 55 60 65 ttt gat aac tac gtt gag ttc ttc act cgt agt gac act ctc caa gtt 355 Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser Asp Thr Leu Gln Val 70 75 80 85 gtt tta aac acc gtc atc ttc acg gca tgt gct gtg atc gga tcg atg 403 Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala Val Ile Gly Ser Met 90 95 100 gtg ctc ggt ttg ctc ctg gcc atg ttg ttg gat cag aag ctt ttc ggc 451 Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp Gln Lys Leu Phe Gly 105 110 115 cgt aac ttt gtg cgt tcc atg gtg ttt gcc ccg ttt gtg att tcc ggt 499 Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro Phe Val Ile Ser Gly 120 125 130 gct gcc att ggt gtt gct ttc cag ttc gtt ttt gac cct aat ttt ggt 547 Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe Asp Pro Asn Phe Gly 135 140 145 ttg gtt cag gac ttg ctg gga cgc atc ggc gtt gat tcg cca cag ttc 595 Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val Asp Ser Pro Gln Phe 150 155 160 165 tac caa aac cct aac tgg gca ttg ttc atg gtg acg ttc act ttc gtg 643 Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val Thr Phe Thr Phe Val 170 175 180 tgg aag aac ttg ggc tac tcc ttt gtt atc tac ctg gct gca ttg cag 691 Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr Leu Ala Ala Leu Gln 185 190 195 ggg cta aac aag gat ttg tct gag gcc gca gcg gtg gat ggc gcg agc 739 Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Ala Val Asp Gly Ala Ser 200 205 210 gcg tgg aca cgt ttt tgg aag gtt act ctt ccg cag ctt cgc cca acc 787 Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro Gln Leu Arg Pro Thr 215 220 225 acg ttc ttc ctt tct att act gtc acg ctg aac tcg gtt cag gtc ttc 835 Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn Ser Val Gln Val Phe 230 235 240 245 gac atc att cac acc atg act cgt ggt ggc ccc ttg ggt aac ggt acg 883 Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro Leu Gly Asn Gly Thr 250 255 260 acc acc ttg gtt tac cag gtg tac acc gag act ttc acc aac tat cgc 931 Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr Phe Thr Asn Tyr Arg 265 270 275 gcg gga tat ggt gca aca atc gca acg att ttg ttc ctg ttg ctg ctg 979 Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu Phe Leu Leu Leu Leu 280 285 290 att atc act gtt atc cag gtt cga tac atg gat aag gag aac aag cag 1027 Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp Lys Glu Asn Lys Gln 295 300 305 aaa tgatctcgac tgatagaaac gttttggtca 1060 Lys 310 <210> 76 <211> 310 <212> PRT <213> Corynebacterium glutamicum <400> 76 Val Ser Thr Leu Ile Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg 1 5 10 15 Ala Lys Arg Ser Arg Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu 20 25 30 Ala Pro Asn Leu Leu Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu 35 40 45 Asp Asn Phe Arg Leu Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr 50 55 60 Ser Thr Phe Ile Gly Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser 65 70 75 80 Asp Thr Leu Gln Val Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala 85 90 95 Val Ile Gly Ser Met Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp 100 105 110 Gln Lys Leu Phe Gly Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro 115 120 125 Phe Val Ile Ser Gly Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe 130 135 140 Asp Pro Asn Phe Gly Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val 145 150 155 160 Asp Ser Pro Gln Phe Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val 165 170 175 Thr Phe Thr Phe Val Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr 180 185 190 Leu Ala Ala Leu Gln Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Ala 195 200 205 Val Asp Gly Ala Ser Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro 210 215 220 Gln Leu Arg Pro Thr Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn 225 230 235 240 Ser Val Gln Val Phe Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro 245 250 255 Leu Gly Asn Gly Thr Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr 260 265 270 Phe Thr Asn Tyr Arg Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu 275 280 285 Phe Leu Leu Leu Leu Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp 290 295 300 Lys Glu Asn Lys Gln Lys 305 310 <210> 77 <211> 2395 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2365) <223> RXA01323 <400> 77 cacgtggttt acgccaggca tgttcccgcg aagggttgac ccatacccct agggggtata 60 cagtgagtca tgtaaacata ctcgcagaag gagcgatccc atg gct cag aca ccc 115 Met Ala Gln Thr Pro 1 5 gcc aaa atc ccg gcg gca ctg aat ttc att gac gtc gac ctc ggc gtt 163 Ala Lys Ile Pro Ala Ala Leu Asn Phe Ile Asp Val Asp Leu Gly Val 10 15 20 acc ggc atg acc tgc act tct tgc tcc gcc cgc gtc gag cgc aaa ctg 211 Thr Gly Met Thr Cys Thr Ser Cys Ser Ala Arg Val Glu Arg Lys Leu 25 30 35 aac aag ctc gac ggc gtt gaa gca acc gtc aac tac gcg acg gaa tcc 259 Asn Lys Leu Asp Gly Val Glu Ala Thr Val Asn Tyr Ala Thr Glu Ser 40 45 50 gca cag gtc agc tac gac ccc tca aag gtc agc cct gaa cag ctg att 307 Ala Gln Val Ser Tyr Asp Pro Ser Lys Val Ser Pro Glu Gln Leu Ile 55 60 65 aag act gtt gag gac acc ggc tac ggt gct ttc acg atg gct tcc gca 355 Lys Thr Val Glu Asp Thr Gly Tyr Gly Ala Phe Thr Met Ala Ser Ala 70 75 80 85 gct gcc gaa tca gaa gag gac aac gct cca gct gac agc ggc cag tcc 403 Ala Ala Glu Ser Glu Glu Asp Asn Ala Pro Ala Asp Ser Gly Gln Ser 90 95 100 cgc atc gac gca gct cgc gac cac gaa gca gcc gac ctg aaa cac cgc 451 Arg Ile Asp Ala Ala Arg Asp His Glu Ala Ala Asp Leu Lys His Arg 105 110 115 gtg atc gtc tct gca ctg ttg tca gtt cct gtg gtt ttg gtc agc atg 499 Val Ile Val Ser Ala Leu Leu Ser Val Pro Val Val Leu Val Ser Met 120 125 130 atc ccg gcg ctg caa ttc aac aac tgg cag tgg gcc gta ctc act ttg 547 Ile Pro Ala Leu Gln Phe Asn Asn Trp Gln Trp Ala Val Leu Thr Leu 135 140 145 gtc acc ccg att ttc ttc tgg ggc ggt tca ccg ttc cac aag gca acg 595 Val Thr Pro Ile Phe Phe Trp Gly Gly Ser Pro Phe His Lys Ala Thr 150 155 160 165 tgg gca aac ctg aag cac ggt tcc ttc acc atg gac acc ctg gtt tca 643 Trp Ala Asn Leu Lys His Gly Ser Phe Thr Met Asp Thr Leu Val Ser 170 175 180 ctc ggc acg tcc gct gct tac ctg tgg tcc ctg tgg gct ttg ttc att 691 Leu Gly Thr Ser Ala Ala Tyr Leu Trp Ser Leu Trp Ala Leu Phe Ile 185 190 195 gga aat gct ggt cac cct ggc atg aag atg gag atg cac ctg ctg ccg 739 Gly Asn Ala Gly His Pro Gly Met Lys Met Glu Met His Leu Leu Pro 200 205 210 tcg gcc tcc acg atg gat gag att tac ctc gaa acc gtc gcg gtc gtt 787 Ser Ala Ser Thr Met Asp Glu Ile Tyr Leu Glu Thr Val Ala Val Val 215 220 225 att acg ttc ctg ctg ctt gga cgc tgg ttt gag aca aaa gct aag ggc 835 Ile Thr Phe Leu Leu Leu Gly Arg Trp Phe Glu Thr Lys Ala Lys Gly 230 235 240 245 caa tct tcg gaa gct ctg cgc aag ctg ctg gac atg ggc gcc aaa gat 883 Gln Ser Ser Glu Ala Leu Arg Lys Leu Leu Asp Met Gly Ala Lys Asp 250 255 260 gca gtc gtc tta cgt gac ggc gcc gaa gtc cgc gtt cct gtg aat cag 931 Ala Val Val Leu Arg Asp Gly Ala Glu Val Arg Val Pro Val Asn Gln 265 270 275 ctt aaa ctc ggc gac gtt ttc atc acc cgc ccc ggc gag aaa atc gcc 979 Leu Lys Leu Gly Asp Val Phe Ile Thr Arg Pro Gly Glu Lys Ile Ala 280 285 290 acc gac ggt gaa gtc gtc gaa ggt tcc tcc gca gtc gac gaa tcc atg 1027 Thr Asp Gly Glu Val Val Glu Gly Ser Ser Ala Val Asp Glu Ser Met 295 300 305 ctc acc ggc gaa tcc atc ccc gtt gaa gtc acc aag ggc tcc aaa gtt 1075 Leu Thr Gly Glu Ser Ile Pro Val Glu Val Thr Lys Gly Ser Lys Val 310 315 320 325 acc ggc gca acg ctg aac act tcc ggc cgc ctc atg gtg aaa gta acc 1123 Thr Gly Ala Thr Leu Asn Thr Ser Gly Arg Leu Met Val Lys Val Thr 330 335 340 cgc atc ggc gcc gac acc acc ctg tcg caa atg gct aaa ctg gtc acg 1171 Arg Ile Gly Ala Asp Thr Thr Leu Ser Gln Met Ala Lys Leu Val Thr 345 350 355 gac gca cag tcc aaa aag gcc cct gtc cag cgt ctt gtt gac caa atc 1219 Asp Ala Gln Ser Lys Lys Ala Pro Val Gln Arg Leu Val Asp Gln Ile 360 365 370 tcg cag gtt ttc gtt ccc gtt gtc atc gta att gct att gcg acg ctg 1267 Ser Gln Val Phe Val Pro Val Val Ile Val Ile Ala Ile Ala Thr Leu 375 380 385 atc gcg cac ctc gtc ttc acc gac gcc ggc ctc gcc cca gca ttc acc 1315 Ile Ala His Leu Val Phe Thr Asp Ala Gly Leu Ala Pro Ala Phe Thr 390 395 400 405 gca gca gtc gcc gtc ctc att atc gcc tgc cct tgt gcc ctc ggc ctg 1363 Ala Ala Val Ala Val Leu Ile Ile Ala Cys Pro Cys Ala Leu Gly Leu 410 415 420 gca acc cca acc gca ctt ctg gtc gga acc ggc cgc ggc gcg caa ctt 1411 Ala Thr Pro Thr Ala Leu Leu Val Gly Thr Gly Arg Gly Ala Gln Leu 425 430 435 ggt ctg ttg atc aag ggc cct gaa atc ctc gaa tcc acc aaa aaa gtc 1459 Gly Leu Leu Ile Lys Gly Pro Glu Ile Leu Glu Ser Thr Lys Lys Val 440 445 450 gac acc atc gtc ctc gac aaa acc ggc acc gtc acc acc ggc acc atg 1507 Asp Thr Ile Val Leu Asp Lys Thr Gly Thr Val Thr Thr Gly Thr Met 455 460 465 tcc gtc acc gac gtc acc gcc atc aac tac agc gaa acc gaa atc ctc 1555 Ser Val Thr Asp Val Thr Ala Ile Asn Tyr Ser Glu Thr Glu Ile Leu 470 475 480 485 gaa ttc gct gca gcc gtc gag tcc gcc tcc gaa cac ccc atc gcc cag 1603 Glu Phe Ala Ala Ala Val Glu Ser Ala Ser Glu His Pro Ile Ala Gln 490 495 500 gca atc gcc aag gcc gcc gaa cac gag caa gtc acc gac ttc caa aac 1651 Ala Ile Ala Lys Ala Ala Glu His Glu Gln Val Thr Asp Phe Gln Asn 505 510 515 acc gca ggt cag gga gtc acc ggt gta gtc cgc gga cac gag gtc cgc 1699 Thr Ala Gly Gln Gly Val Thr Gly Val Val Arg Gly His Glu Val Arg 520 525 530 gtg ggc agg cct tca agc acg ctt atc gac gcc ctc ctc cac ccc ttc 1747 Val Gly Arg Pro Ser Ser Thr Leu Ile Asp Ala Leu Leu His Pro Phe 535 540 545 caa cac gcc caa aaa atc ggc gga acc ccc gta gtc gtc acg att gac 1795 Gln His Ala Gln Lys Ile Gly Gly Thr Pro Val Val Val Thr Ile Asp 550 555 560 565 ggc gta gat tcc gga ata atc acg gtc cgc gac acc gtc aaa gac acc 1843 Gly Val Asp Ser Gly Ile Ile Thr Val Arg Asp Thr Val Lys Asp Thr 570 575 580 tcc gcc gaa gca atc cgc gga ctc aag gaa ctg gga ctc acc cca atc 1891 Ser Ala Glu Ala Ile Arg Gly Leu Lys Glu Leu Gly Leu Thr Pro Ile 585 590 595 cta ctc acc gga gac aat gaa ggc gca gct aaa tcc gta gcc gct gaa 1939 Leu Leu Thr Gly Asp Asn Glu Gly Ala Ala Lys Ser Val Ala Ala Glu 600 605 610 gtc ggc atc gac caa gtc atc gcc aac gtc ctc ccc cac gaa aaa gtc 1987 Val Gly Ile Asp Gln Val Ile Ala Asn Val Leu Pro His Glu Lys Val 615 620 625 caa aac gta gaa gcc ctc caa gca caa ggc aaa aac gtt gcg atg gtc 2035 Gln Asn Val Glu Ala Leu Gln Ala Gln Gly Lys Asn Val Ala Met Val 630 635 640 645 ggc gac ggc gtc aac gat gcc gca gct ctt gcc caa gct gac ctc gga 2083 Gly Asp Gly Val Asn Asp Ala Ala Ala Leu Ala Gln Ala Asp Leu Gly 650 655 660 ctc gcc atg gga gcc ggc acc gac gta gcc atc gaa gcc tcc gac atc 2131 Leu Ala Met Gly Ala Gly Thr Asp Val Ala Ile Glu Ala Ser Asp Ile 665 670 675 acc ctc atg aac aac gac ctc cga tcc gca gtc gac gcc atc cga ctg 2179 Thr Leu Met Asn Asn Asp Leu Arg Ser Ala Val Asp Ala Ile Arg Leu 680 685 690 tcc cgt aaa acc ctc ggc acc atc aag gga aac ctt ttc tgg gct ttc 2227 Ser Arg Lys Thr Leu Gly Thr Ile Lys Gly Asn Leu Phe Trp Ala Phe 695 700 705 gcc tac aat gtt gca cta atc cca gta gcg gcg atc gga ctc ctc aac 2275 Ala Tyr Asn Val Ala Leu Ile Pro Val Ala Ala Ile Gly Leu Leu Asn 710 715 720 725 cca atg ctt gcc ggc att gcg atg gcc ttc agt tca gtt ttc gtc gtc 2323 Pro Met Leu Ala Gly Ile Ala Met Ala Phe Ser Ser Val Phe Val Val 730 735 740 tcc aat tcc ttg cgt ctg cga gga ttc aaa gca agg agc aac 2365 Ser Asn Ser Leu Arg Leu Arg Gly Phe Lys Ala Arg Ser Asn 745 750 755 taatgtccaa cagcgaatgc cacacccacg 2395 <210> 78 <211> 755 <212> PRT <213> Corynebacterium glutamicum <400> 78 Met Ala Gln Thr Pro Ala Lys Ile Pro Ala Ala Leu Asn Phe Ile Asp 1 5 10 15 Val Asp Leu Gly Val Thr Gly Met Thr Cys Thr Ser Cys Ser Ala Arg 20 25 30 Val Glu Arg Lys Leu Asn Lys Leu Asp Gly Val Glu Ala Thr Val Asn 35 40 45 Tyr Ala Thr Glu Ser Ala Gln Val Ser Tyr Asp Pro Ser Lys Val Ser 50 55 60 Pro Glu Gln Leu Ile Lys Thr Val Glu Asp Thr Gly Tyr Gly Ala Phe 65 70 75 80 Thr Met Ala Ser Ala Ala Ala Glu Ser Glu Glu Asp Asn Ala Pro Ala 85 90 95 Asp Ser Gly Gln Ser Arg Ile Asp Ala Ala Arg Asp His Glu Ala Ala 100 105 110 Asp Leu Lys His Arg Val Ile Val Ser Ala Leu Leu Ser Val Pro Val 115 120 125 Val Leu Val Ser Met Ile Pro Ala Leu Gln Phe Asn Asn Trp Gln Trp 130 135 140 Ala Val Leu Thr Leu Val Thr Pro Ile Phe Phe Trp Gly Gly Ser Pro 145 150 155 160 Phe His Lys Ala Thr Trp Ala Asn Leu Lys His Gly Ser Phe Thr Met 165 170 175 Asp Thr Leu Val Ser Leu Gly Thr Ser Ala Ala Tyr Leu Trp Ser Leu 180 185 190 Trp Ala Leu Phe Ile Gly Asn Ala Gly His Pro Gly Met Lys Met Glu 195 200 205 Met His Leu Leu Pro Ser Ala Ser Thr Met Asp Glu Ile Tyr Leu Glu 210 215 220 Thr Val Ala Val Val Ile Thr Phe Leu Leu Leu Gly Arg Trp Phe Glu 225 230 235 240 Thr Lys Ala Lys Gly Gln Ser Ser Glu Ala Leu Arg Lys Leu Leu Asp 245 250 255 Met Gly Ala Lys Asp Ala Val Val Leu Arg Asp Gly Ala Glu Val Arg 260 265 270 Val Pro Val Asn Gln Leu Lys Leu Gly Asp Val Phe Ile Thr Arg Pro 275 280 285 Gly Glu Lys Ile Ala Thr Asp Gly Glu Val Val Glu Gly Ser Ser Ala 290 295 300 Val Asp Glu Ser Met Leu Thr Gly Glu Ser Ile Pro Val Glu Val Thr 305 310 315 320 Lys Gly Ser Lys Val Thr Gly Ala Thr Leu Asn Thr Ser Gly Arg Leu 325 330 335 Met Val Lys Val Thr Arg Ile Gly Ala Asp Thr Thr Leu Ser Gln Met 340 345 350 Ala Lys Leu Val Thr Asp Ala Gln Ser Lys Lys Ala Pro Val Gln Arg 355 360 365 Leu Val Asp Gln Ile Ser Gln Val Phe Val Pro Val Val Ile Val Ile 370 375 380 Ala Ile Ala Thr Leu Ile Ala His Leu Val Phe Thr Asp Ala Gly Leu 385 390 395 400 Ala Pro Ala Phe Thr Ala Ala Val Ala Val Leu Ile Ile Ala Cys Pro 405 410 415 Cys Ala Leu Gly Leu Ala Thr Pro Thr Ala Leu Leu Val Gly Thr Gly 420 425 430 Arg Gly Ala Gln Leu Gly Leu Leu Ile Lys Gly Pro Glu Ile Leu Glu 435 440 445 Ser Thr Lys Lys Val Asp Thr Ile Val Leu Asp Lys Thr Gly Thr Val 450 455 460 Thr Thr Gly Thr Met Ser Val Thr Asp Val Thr Ala Ile Asn Tyr Ser 465 470 475 480 Glu Thr Glu Ile Leu Glu Phe Ala Ala Ala Val Glu Ser Ala Ser Glu 485 490 495 His Pro Ile Ala Gln Ala Ile Ala Lys Ala Ala Glu His Glu Gln Val 500 505 510 Thr Asp Phe Gln Asn Thr Ala Gly Gln Gly Val Thr Gly Val Val Arg 515 520 525 Gly His Glu Val Arg Val Gly Arg Pro Ser Ser Thr Leu Ile Asp Ala 530 535 540 Leu Leu His Pro Phe Gln His Ala Gln Lys Ile Gly Gly Thr Pro Val 545 550 555 560 Val Val Thr Ile Asp Gly Val Asp Ser Gly Ile Ile Thr Val Arg Asp 565 570 575 Thr Val Lys Asp Thr Ser Ala Glu Ala Ile Arg Gly Leu Lys Glu Leu 580 585 590 Gly Leu Thr Pro Ile Leu Leu Thr Gly Asp Asn Glu Gly Ala Ala Lys 595 600 605 Ser Val Ala Ala Glu Val Gly Ile Asp Gln Val Ile Ala Asn Val Leu 610 615 620 Pro His Glu Lys Val Gln Asn Val Glu Ala Leu Gln Ala Gln Gly Lys 625 630 635 640 Asn Val Ala Met Val Gly Asp Gly Val Asn Asp Ala Ala Ala Leu Ala 645 650 655 Gln Ala Asp Leu Gly Leu Ala Met Gly Ala Gly Thr Asp Val Ala Ile 660 665 670 Glu Ala Ser Asp Ile Thr Leu Met Asn Asn Asp Leu Arg Ser Ala Val 675 680 685 Asp Ala Ile Arg Leu Ser Arg Lys Thr Leu Gly Thr Ile Lys Gly Asn 690 695 700 Leu Phe Trp Ala Phe Ala Tyr Asn Val Ala Leu Ile Pro Val Ala Ala 705 710 715 720 Ile Gly Leu Leu Asn Pro Met Leu Ala Gly Ile Ala Met Ala Phe Ser 725 730 735 Ser Val Phe Val Val Ser Asn Ser Leu Arg Leu Arg Gly Phe Lys Ala 740 745 750 Arg Ser Asn 755 <210> 79 <211> 2041 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2011) <223> RXA01338 <400> 79 ggtcgttggc cttattattt tagggaaagc ccatccttac cttgccaagg gaagcctgta 60 catgctggtc agggacattt ttatgggtga taatggggtt atg aat aaa aaa ctt 115 Met Asn Lys Lys Leu 1 5 aat acc cca aat ccc tgg atg tta ttc atc cgc tca ttt gat ggc atc 163 Asn Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp Gly Ile 10 15 20 atc act gtc gca gcc ctt gtt gcc atc gca ata cat ctc att tta tgg 211 Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile Leu Trp 25 30 35 ctg gct cta gat cta gat ggc ctt gct aaa aac tgg cct tta ata gcc 259 Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu Ile Ala 40 45 50 atc gtt atc gta ggt ggc att ccg ttg atg tgg gat gtg ctg aaa tca 307 Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu Lys Ser 55 60 65 gcc att aaa act cgc ggt ggc gcg gat act tta gca gca gtc tcc atc 355 Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val Ser Ile 70 75 80 85 att act tct gtg ttg tta ggg gag tgg ttg gtt gcc gcg atc atc gtg 403 Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile Ile Val 90 95 100 ctc atg ctc tct ggt ggt gaa gcg cta gaa gag gca gca tca cgg cga 451 Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser Arg Arg 105 110 115 gcc agt ggc acc ttg gac gca ctt gcc cgg cgc gca cca agt aca gct 499 Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser Thr Ala 120 125 130 cac cgc ctg ttg ggt gca acc att ctt gat gga acc gaa gag atc gcc 547 His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu Ile Ala 135 140 145 gtg gaa gag atc acg gtt ggt gat tta gtg gcg gtg ctc ccg cat gaa 595 Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro His Glu 150 155 160 165 ctt tgt ccc gtg gat ggt gaa atc gtg gca ggc cac ggc acc atg gat 643 Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr Met Asp 170 175 180 gag tct tat ctc acg ggt gag ccc tat gtg gtg agt aaa tct aaa ggt 691 Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser Lys Gly 185 190 195 tcg caa gca atg tcg ggt gca gtc aat ggt gat act ccg ctg acg att 739 Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu Thr Ile 200 205 210 gtt gcc aca aag ctt gcc cat gat tcc aga tac gcc caa att gtt ggt 787 Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile Val Gly 215 220 225 gta ctc cat gaa gca gaa aac aac cgc cca gaa atg cgc agg atg gct 835 Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg Met Ala 230 235 240 245 gac cgt ctt ggc gcg tgg tat acg gtg att gca ctt gcc ctc ggt ggt 883 Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu Gly Gly 250 255 260 ctt ggc tgg att gtc tcc ggc gac cca gtg agg ttc ttg gct gtt gtc 931 Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala Val Val 265 270 275 gtt gtc gcc acc cca tgt cca ttg ctc att gca gtg cca gtg gcg atc 979 Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val Ala Ile 280 285 290 atc ggt gcg att tct ctt gcg gct cgt cgg ggc atc atc gtg aag aac 1027 Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val Lys Asn 295 300 305 cct gga atg ctg gaa aac gct tca gga gta aag aca gtg atg ttc gat 1075 Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met Phe Asp 310 315 320 325 aag act gga acg ctc acc tat ggc agg cca gtg att act gat atc cac 1123 Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp Ile His 330 335 340 act gct ccc gga gtt gag gaa gat aca gtc cta gct ttg gct gct tca 1171 Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala Ala Ser 345 350 355 gta gag cgc tac tcc aga cac ccg ttg gct gac gcg att cgt gag ggc 1219 Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg Glu Gly 360 365 370 gca aaa gcc agg gaa ctt cat ctg cct gat gta gtg gaa gta tcg gaa 1267 Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val Ser Glu 375 380 385 cgt cca gga cag gga cta acc ggc acg gtg ggc gag cac ctg gtt cga 1315 Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu Val Arg 390 395 400 405 ata acc aat agg cgc agc aca cta gaa att gat cca gac agc aag aac 1363 Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser Lys Asn 410 415 420 tac att ccg gtg aca agt tcc ggc atg gaa tct gtg gtg ctt gtt gat 1411 Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu Val Asp 425 430 435 gat aaa tat gca gca ctc att cgc ctc cgg gat gaa cct cgt gca tct 1459 Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg Ala Ser 440 445 450 gcc agt gag ttc atc gcg cac ttg ccc aag aag cac aaa gtg gac aag 1507 Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val Asp Lys 455 460 465 ctc atg att atc tct ggt gat cgc gca tct gag gtt cgt tac ctt gcg 1555 Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr Leu Ala 470 475 480 485 gac aag gtt ggc att gat gag gta cac gca gag gcc tca ccg gaa gac 1603 Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro Glu Asp 490 495 500 aag ctg aac att gtt aat cgg cat aat gag cac ggc gcc acc atg ttc 1651 Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr Met Phe 505 510 515 tta ggt gat gga atc aac gat gcg cca gcc atg gcc gtt gcc acc gtt 1699 Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala Thr Val 520 525 530 ggt gtc gcg atg gga gca gac tcc gat gtc acg tcc gaa gca gca gat 1747 Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala Ala Asp 535 540 545 gct gtg att ttg gat tct tcc ctg gaa cgt ctc gac gat ctg ctc cac 1795 Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu Leu His 550 555 560 565 atc agt gca cgg atg cgt cga ata gcg ttg caa tct gcg ggc ggt ggc 1843 Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly Gly Gly 570 575 580 atg gcg ttg agt gtc ata gga atg atc ctc gcg gta ttt gga ttc ttg 1891 Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly Phe Leu 585 590 595 acg cca ctg atg ggt gcg atc ttc caa gag gtc att gac gtg ctg gct 1939 Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val Leu Ala 600 605 610 atc ctc aat tcc gct cgg gtc gca ctg cca cgc gga gcg att agt gat 1987 Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile Ser Asp 615 620 625 ttt gat acg caa gaa aaa gtt tct tagcagggta acctaaatgt cgtgacattt 2041 Phe Asp Thr Gln Glu Lys Val Ser 630 635 <210> 80 <211> 637 <212> PRT <213> Corynebacterium glutamicum <400> 80 Met Asn Lys Lys Leu Asn Thr Pro Asn Pro Trp Met Leu Phe Ile Arg 1 5 10 15 Ser Phe Asp Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile 20 25 30 His Leu Ile Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn 35 40 45 Trp Pro Leu Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp 50 55 60 Asp Val Leu Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu 65 70 75 80 Ala Ala Val Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val 85 90 95 Ala Ala Ile Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu 100 105 110 Ala Ala Ser Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg 115 120 125 Ala Pro Ser Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly 130 135 140 Thr Glu Glu Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala 145 150 155 160 Val Leu Pro His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly 165 170 175 His Gly Thr Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val 180 185 190 Ser Lys Ser Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp 195 200 205 Thr Pro Leu Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr 210 215 220 Ala Gln Ile Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu 225 230 235 240 Met Arg Arg Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala 245 250 255 Leu Ala Leu Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg 260 265 270 Phe Leu Ala Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala 275 280 285 Val Pro Val Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly 290 295 300 Ile Ile Val Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys 305 310 315 320 Thr Val Met Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val 325 330 335 Ile Thr Asp Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu 340 345 350 Ala Leu Ala Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp 355 360 365 Ala Ile Arg Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val 370 375 380 Val Glu Val Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly 385 390 395 400 Glu His Leu Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp 405 410 415 Pro Asp Ser Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser 420 425 430 Val Val Leu Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp 435 440 445 Glu Pro Arg Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys 450 455 460 His Lys Val Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu 465 470 475 480 Val Arg Tyr Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu 485 490 495 Ala Ser Pro Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His 500 505 510 Gly Ala Thr Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met 515 520 525 Ala Val Ala Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr 530 535 540 Ser Glu Ala Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu 545 550 555 560 Asp Asp Leu Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln 565 570 575 Ser Ala Gly Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala 580 585 590 Val Phe Gly Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val 595 600 605 Ile Asp Val Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg 610 615 620 Gly Ala Ile Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625 630 635 <210> 81 <211> 1375 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1345) <223> RXA01339 <400> 81 gagaaggcgg aaccgaagga atcgaagaat atctctccgt gcgttacctc gctttgccgt 60 gacacatgag ctgtccggtg aataacccga aggaaaaaac atg act acc gaa tca 115 Met Thr Thr Glu Ser 1 5 ata gtt gcg cac aat gct gca ggt aca gca cct cag aat gtg tcc tct 163 Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro Gln Asn Val Ser Ser 10 15 20 gct aag aag aag tac ctc agc gtt gcc caa ggc gtt gcc ctt atc tac 211 Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly Val Ala Leu Ile Tyr 25 30 35 gga acc aac atc ggc gcc ggt gtg ctc agc ctc cca tac gct gcc cgc 259 Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu Pro Tyr Ala Ala Arg 40 45 50 aac ggt ggt ttc ctc gcc ctg gtt gtt gcc ctg ctc att gcg gga aca 307 Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu Leu Ile Ala Gly Thr 55 60 65 ctg acc acc atc tcc atg ctc tac atc gcc gaa gta tcc ctg cgc acc 355 Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu Val Ser Leu Arg Thr 70 75 80 85 aag aag cca ctg cag ctt tcc ggc ctg gca gaa aaa tac ctg ggg cag 403 Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu Lys Tyr Leu Gly Gln 90 95 100 tgg ggc cgc tgg ctg gtg ttc att gcc att gtg gtc aac agc gtg ggt 451 Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val Val Asn Ser Val Gly 105 110 115 gca ctg att gcc tac gca tca gga tcc ggc att ttg ata ggc aac ctc 499 Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile Leu Ile Gly Asn Leu 120 125 130 acc ggc ctg cca cca atc gtg ggc acc ctt gga ttc ttt gtt tta ggc 547 Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly Phe Phe Val Leu Gly 135 140 145 acc ttg atc atg tgg aaa ggc ctg cac acg gca agc ttc gtg gag gca 595 Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala Ser Phe Val Glu Ala 150 155 160 165 ttg atc acc act ggc atg gca acg atc atc atc gtg ctg tgt gga tgg 643 Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile Val Leu Cys Gly Trp 170 175 180 aca gtg ctt ggc cct gga att tcc gca gac aac ctg atc gtg ttc cac 691 Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn Leu Ile Val Phe His 185 190 195 cca ttc ttc atc gtt ccg atc atg aac ctc gcg gtc ttt acc ttc ctt 739 Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala Val Phe Thr Phe Leu 200 205 210 gcc caa tat gtg gtt cca gaa atc gca cga gga gtt aac cct gcc acc 787 Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly Val Asn Pro Ala Thr 215 220 225 ccg aag gca gtg cca cgc gcg atc atc atc ggc atg gtc gca act ggt 835 Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly Met Val Ala Thr Gly 230 235 240 245 gtc acc ctg gca gct gta cca ttc gcg gca cta ggg ctt ctg ggc aca 883 Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu Gly Leu Leu Gly Thr 250 255 260 ggc gtc agt gaa gtt gtc acc atc tcc tgg ggc gaa gca ctc gcc cca 931 Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly Glu Ala Leu Ala Pro 265 270 275 gtg gcc tat tac atg gcc aat gcc ttc gca cta ttg gcc atg ttc act 979 Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu Leu Ala Met Phe Thr 280 285 290 tca ttc atc gcc att gga ttc acc gcg atg cgc aac gta cta gat att 1027 Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg Asn Val Leu Asp Ile 295 300 305 ggc cac tgg cca caa cac gga tgg cag cga tcc gtt gct gtc gga cta 1075 Gly His Trp Pro Gln His Gly Trp Gln Arg Ser Val Ala Val Gly Leu 310 315 320 325 act gtt ctt cca cca ctg gca att tca ctt gcg gga tta ggc gga ttc 1123 Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala Gly Leu Gly Gly Phe 330 335 340 gtg gca gca ctg agc tac gcc gga gga ttt gcc gga gca atc atg tcc 1171 Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala Gly Ala Ile Met Ser 345 350 355 atc atc ccc gtg ctg ttg ctg cgc aac tcc cgc aag agt ggt gac caa 1219 Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg Lys Ser Gly Asp Gln 360 365 370 gaa cca gtg tgg aaa gcc acc tgg caa gcg cac ccc atc ttc cag atc 1267 Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His Pro Ile Phe Gln Ile 375 380 385 ctg ttg att gtg gtg tac tcc ctg gcg ttt gtg tac tcg gtt ctc gcg 1315 Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val Tyr Ser Val Leu Ala 390 395 400 405 atc gtc gga tta atg cct gcg ggt tgg gca tagtcacttc ctgttgtggc 1365 Ile Val Gly Leu Met Pro Ala Gly Trp Ala 410 415 tgcctgttgc 1375 <210> 82 <211> 415 <212> PRT <213> Corynebacterium glutamicum <400> 82 Met Thr Thr Glu Ser Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro 1 5 10 15 Gln Asn Val Ser Ser Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly 20 25 30 Val Ala Leu Ile Tyr Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu 35 40 45 Pro Tyr Ala Ala Arg Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu 50 55 60 Leu Ile Ala Gly Thr Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu 65 70 75 80 Val Ser Leu Arg Thr Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu 85 90 95 Lys Tyr Leu Gly Gln Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val 100 105 110 Val Asn Ser Val Gly Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile 115 120 125 Leu Ile Gly Asn Leu Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly 130 135 140 Phe Phe Val Leu Gly Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala 145 150 155 160 Ser Phe Val Glu Ala Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile 165 170 175 Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn 180 185 190 Leu Ile Val Phe His Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala 195 200 205 Val Phe Thr Phe Leu Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly 210 215 220 Val Asn Pro Ala Thr Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly 225 230 235 240 Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu 245 250 255 Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly 260 265 270 Glu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu 275 280 285 Leu Ala Met Phe Thr Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg 290 295 300 Asn Val Leu Asp Ile Gly His Trp Pro Gln His Gly Trp Gln Arg Ser 305 310 315 320 Val Ala Val Gly Leu Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala 325 330 335 Gly Leu Gly Gly Phe Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala 340 345 350 Gly Ala Ile Met Ser Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg 355 360 365 Lys Ser Gly Asp Gln Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His 370 375 380 Pro Ile Phe Gln Ile Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val 385 390 395 400 Tyr Ser Val Leu Ala Ile Val Gly Leu Met Pro Ala Gly Trp Ala 405 410 415 <210> 83 <211> 1081 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1051) <223> RXA01425 <400> 83 ccggtgccga accatggatt ttggtccacc gaaacggtga catagaagtc ctgccaacaa 60 gtacatagtc cctattaatc ccaaggagtt tcgactcaca gtg ctc aat ttc att 115 Val Leu Asn Phe Ile 1 5 tat tgg cca att tcg gcc att ctg tgg ttc tgg cat aaa gcg ttc agc 163 Tyr Trp Pro Ile Ser Ala Ile Leu Trp Phe Trp His Lys Ala Phe Ser 10 15 20 ttt gtg ctg agc cca gat tcc gga att acc tgg gcc ttg tcg atc atg 211 Phe Val Leu Ser Pro Asp Ser Gly Ile Thr Trp Ala Leu Ser Ile Met 25 30 35 ttc ttg acc ttc acc gtg cgt atg gtt ctg gtc aag ccg atg gtc aac 259 Phe Leu Thr Phe Thr Val Arg Met Val Leu Val Lys Pro Met Val Asn 40 45 50 acc atg cgt tca cag cgc aag atg caa gac atg gct cca aag atg cag 307 Thr Met Arg Ser Gln Arg Lys Met Gln Asp Met Ala Pro Lys Met Gln 55 60 65 gcc atc cgc gag aag tac aaa aat gac cag cag aag atg atg gag gag 355 Ala Ile Arg Glu Lys Tyr Lys Asn Asp Gln Gln Lys Met Met Glu Glu 70 75 80 85 acc cgc aaa ctt caa aaa gaa gtg ggc gtt aac ccc atc gca ggc tgt 403 Thr Arg Lys Leu Gln Lys Glu Val Gly Val Asn Pro Ile Ala Gly Cys 90 95 100 ttg cca atg ttg gtg cag atc cca gtg ttc ctg ggt ctg ttc cac gtg 451 Leu Pro Met Leu Val Gln Ile Pro Val Phe Leu Gly Leu Phe His Val 105 110 115 ctg cgc tcc ttc aac cgc acc ggt tct ggc gtt ggc cag ctg gaa atg 499 Leu Arg Ser Phe Asn Arg Thr Gly Ser Gly Val Gly Gln Leu Glu Met 120 125 130 acc gtt gag caa aac gcg aac acc ccg aac tac atc ttc ggt gtc gac 547 Thr Val Glu Gln Asn Ala Asn Thr Pro Asn Tyr Ile Phe Gly Val Asp 135 140 145 gag gtt cag tcc ttc ctg cgt gca gac ctg ttc ggt gcg cca ctg tcg 595 Glu Val Gln Ser Phe Leu Arg Ala Asp Leu Phe Gly Ala Pro Leu Ser 150 155 160 165 tcc tac atc acc atg cct gct gac gcg ttc gac gcg ttc ctt ggc ctg 643 Ser Tyr Ile Thr Met Pro Ala Asp Ala Phe Asp Ala Phe Leu Gly Leu 170 175 180 gat gtc tcc cgc ctc aac atc gcg ctg gtt gca gct cca atg att ttg 691 Asp Val Ser Arg Leu Asn Ile Ala Leu Val Ala Ala Pro Met Ile Leu 185 190 195 atc att gtc gtg gca act cac atg aac gcg cgt ctg tcc gtc aac cgc 739 Ile Ile Val Val Ala Thr His Met Asn Ala Arg Leu Ser Val Asn Arg 200 205 210 cag gaa gct cgc aag gca gcc ggc aag cag cag gcc gct tcc agc gat 787 Gln Glu Ala Arg Lys Ala Ala Gly Lys Gln Gln Ala Ala Ser Ser Asp 215 220 225 cag atg gcc atg cag atg caa atg atg aac aag atg atg ctc tgg ttc 835 Gln Met Ala Met Gln Met Gln Met Met Asn Lys Met Met Leu Trp Phe 230 235 240 245 atg cca gcc acc att ttg ttc acc ggc ttc atc tgg acc atc ggt ctt 883 Met Pro Ala Thr Ile Leu Phe Thr Gly Phe Ile Trp Thr Ile Gly Leu 250 255 260 ctt gtc tac atg atg tcc aac aac gtg tgg acc ttc ttc cag cag cgc 931 Leu Val Tyr Met Met Ser Asn Asn Val Trp Thr Phe Phe Gln Gln Arg 265 270 275 tac atc ttc gcc aag atg gac gct gag gaa gca gct gag gag gag gaa 979 Tyr Ile Phe Ala Lys Met Asp Ala Glu Glu Ala Ala Glu Glu Glu Glu 280 285 290 aag cgc gca gca aag cgc act acc gct cca aag cct ggc gtg aag cca 1027 Lys Arg Ala Ala Lys Arg Thr Thr Ala Pro Lys Pro Gly Val Lys Pro 295 300 305 gaa aac ccc aag aag cgt aag aag taaaacttca ctaaaaaccg ccagcccacg 1081 Glu Asn Pro Lys Lys Arg Lys Lys 310 315 <210> 84 <211> 317 <212> PRT <213> Corynebacterium glutamicum <400> 84 Val Leu Asn Phe Ile Tyr Trp Pro Ile Ser Ala Ile Leu Trp Phe Trp 1 5 10 15 His Lys Ala Phe Ser Phe Val Leu Ser Pro Asp Ser Gly Ile Thr Trp 20 25 30 Ala Leu Ser Ile Met Phe Leu Thr Phe Thr Val Arg Met Val Leu Val 35 40 45 Lys Pro Met Val Asn Thr Met Arg Ser Gln Arg Lys Met Gln Asp Met 50 55 60 Ala Pro Lys Met Gln Ala Ile Arg Glu Lys Tyr Lys Asn Asp Gln Gln 65 70 75 80 Lys Met Met Glu Glu Thr Arg Lys Leu Gln Lys Glu Val Gly Val Asn 85 90 95 Pro Ile Ala Gly Cys Leu Pro Met Leu Val Gln Ile Pro Val Phe Leu 100 105 110 Gly Leu Phe His Val Leu Arg Ser Phe Asn Arg Thr Gly Ser Gly Val 115 120 125 Gly Gln Leu Glu Met Thr Val Glu Gln Asn Ala Asn Thr Pro Asn Tyr 130 135 140 Ile Phe Gly Val Asp Glu Val Gln Ser Phe Leu Arg Ala Asp Leu Phe 145 150 155 160 Gly Ala Pro Leu Ser Ser Tyr Ile Thr Met Pro Ala Asp Ala Phe Asp 165 170 175 Ala Phe Leu Gly Leu Asp Val Ser Arg Leu Asn Ile Ala Leu Val Ala 180 185 190 Ala Pro Met Ile Leu Ile Ile Val Val Ala Thr His Met Asn Ala Arg 195 200 205 Leu Ser Val Asn Arg Gln Glu Ala Arg Lys Ala Ala Gly Lys Gln Gln 210 215 220 Ala Ala Ser Ser Asp Gln Met Ala Met Gln Met Gln Met Met Asn Lys 225 230 235 240 Met Met Leu Trp Phe Met Pro Ala Thr Ile Leu Phe Thr Gly Phe Ile 245 250 255 Trp Thr Ile Gly Leu Leu Val Tyr Met Met Ser Asn Asn Val Trp Thr 260 265 270 Phe Phe Gln Gln Arg Tyr Ile Phe Ala Lys Met Asp Ala Glu Glu Ala 275 280 285 Ala Glu Glu Glu Glu Lys Arg Ala Ala Lys Arg Thr Thr Ala Pro Lys 290 295 300 Pro Gly Val Lys Pro Glu Asn Pro Lys Lys Arg Lys Lys 305 310 315 <210> 85 <211> 421 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(391) <223> RXA01467 <400> 85 gcgtcatctt tagccttgct ttatgagctt ttccccgcaa tgagccgcgt tgtgtatcca 60 taagtcttag cctacaagcg ctttgaggta gtttgggatc atg gat ttc aac gac 115 Met Asp Phe Asn Asp 1 5 aaa gcc gct tca gaa aac gct gta aag act ggc gca gaa ggc ccc aac 163 Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn 10 15 20 gtt ttc gcg agc gtg gcc aag att ttg cag gat gtt ggc gga att tca 211 Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp Val Gly Gly Ile Ser 25 30 35 gcc gaa gac gtc act ccg gaa tct cgt ttt act gag gat ttg gca gtg 259 Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Ala Val 40 45 50 agc tca ctc aat tac atc gag ttg att gtc aat gcg gag gac gca ttt 307 Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn Ala Glu Asp Ala Phe 55 60 65 ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag 355 Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp Leu Thr Thr Val Gln 70 75 80 85 gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa 401 Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala Asp 90 95 atttcgccca aaacagggac 421 <210> 86 <211> 97 <212> PRT <213> Corynebacterium glutamicum <400> 86 Met Asp Phe Asn Asp Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly 1 5 10 15 Ala Glu Gly Pro Asn Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp 20 25 30 Val Gly Gly Ile Ser Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr 35 40 45 Glu Asp Leu Ala Val Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn 50 55 60 Ala Glu Asp Ala Phe Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp 65 70 75 80 Leu Thr Thr Val Gln Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala 85 90 95 Asp <210> 87 <211> 1642 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1612) <223> RXA01629 <400> 87 caggaagaag ttaacaccgc ccaggggtgc gttggatgat gatcatctac aaacaaacat 60 tccgttatgc actcataaga tatgacgaga ggttttactc gtg agc ccg att cgc 115 Val Ser Pro Ile Arg 1 5 tca aaa aag aaa atc aag aac gaa cca aga cta aca gtc gat gac gtc 163 Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu Thr Val Asp Asp Val 10 15 20 aac gtt gtt ccc cca aag aag atc cgt ccg gcc att aaa ggc act gtg 211 Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala Ile Lys Gly Thr Val 25 30 35 gtg ggt aac ttc atg gag tgg tac gac ttc gga att tat ggt tat ttg 259 Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly Ile Tyr Gly Tyr Leu 40 45 50 acg gtc acg atg acc gca gta ttt acc caa ggc ctg ccg caa gaa tgg 307 Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly Leu Pro Gln Glu Trp 55 60 65 cag ttg ttg gcc gtg atg ttt ggt ttc gcg gtg tct tat tta gtt cgc 355 Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val Ser Tyr Leu Val Arg 70 75 80 85 ccg ctt ggt ggc ctg gtt ctg ggt ccg ctt ggc gat aag gtt ggc cgc 403 Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly Asp Lys Val Gly Arg 90 95 100 cag aag gtt ttg tac gta acc atg gcc atg atg gcc gtg tct acg gcg 451 Gln Lys Val Leu Tyr Val Thr Met Ala Met Met Ala Val Ser Thr Ala 105 110 115 ctg att ggc ttg ctg ccg acg gcg gcg tcg ata ggc gct tgg gct ttg 499 Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile Gly Ala Trp Ala Leu 120 125 130 gtg ctt ttg tac ctg ttg aag atg gtg cag gga ttt tcg act ggt ggt 547 Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly Phe Ser Thr Gly Gly 135 140 145 gaa tat gct ggt gcg acc acc tat gtt gct gag ttt gcg ccg gat cgt 595 Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu Phe Ala Pro Asp Arg 150 155 160 165 cga cga ggt ttc ttc gga gct ttc cta gat atg ggt tcc tac ctg ggc 643 Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met Gly Ser Tyr Leu Gly 170 175 180 ttt gcc gcg ggt gct tcg gtc gtg gcg att act acc tgg gtg acc act 691 Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr Thr Trp Val Thr Thr 185 190 195 cac ttc tat ggc gca act gcc atg gag gat ttc ggt tgg cgt att cct 739 His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe Gly Trp Arg Ile Pro 200 205 210 ttc ctg act gcg atc ccg ctg ggc atc att gcg gtg tac ctg cgt act 787 Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala Val Tyr Leu Arg Thr 215 220 225 cgt atc cct gag acc cct gcg ttt gag aac aac caa gac gag cca aat 835 Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn Gln Asp Glu Pro Asn 230 235 240 245 gca gtt gtt gaa aag gac act gaa gat cct tat gca cgc ctg ggc ctg 883 Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr Ala Arg Leu Gly Leu 250 255 260 gct ggt gtt atc cgc cac cac tgg cgt cca ctg ctg att ggt att gcg 931 Ala Gly Val Ile Arg His His Trp Arg Pro Leu Leu Ile Gly Ile Ala 265 270 275 att gtg gca gcg acc aac acc gcc ggt tac gcg cta acc agt tac atg 979 Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala Leu Thr Ser Tyr Met 280 285 290 cct gtg tat cta gag gag cag atc ggt ctg cac tcc gca tcc gct gcc 1027 Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His Ser Ala Ser Ala Ala 295 300 305 gct gtg acc gtg ccg att ctg gtt gtt atg tcc ctg ctg ctg cca ttt 1075 Ala Val Thr Val Pro Ile Leu Val Val Met Ser Leu Leu Leu Pro Phe 310 315 320 325 gtt ggt atg tgg agt gac cgc gtg ggc cgc aag cct gtc tac gcg act 1123 Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys Pro Val Tyr Ala Thr 330 335 340 gct gtt gcg gca acg ctg atc ttg atg gtt cct gcc ttc ttg atc atg 1171 Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro Ala Phe Leu Ile Met 345 350 355 aac acc gga acc atc ggc gcc gta ctg att gca ctg tcc atg gtt gct 1219 Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala Leu Ser Met Val Ala 360 365 370 att cca acc ggt ttg tat gtg gca ctg tcc gca tct gcc ctg cca gcg 1267 Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala Ser Ala Leu Pro Ala 375 380 385 ctg ttc cca acc gcg tca cga ttc tct gga atg ggt att tcc tac aac 1315 Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met Gly Ile Ser Tyr Asn 390 395 400 405 att tcc gtg tcg ttg ttc ggt ggt aca acc ccg ctg atc acc cag ttc 1363 Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro Leu Ile Thr Gln Phe 410 415 420 ctg ctg cag aag act ggc ctg gat atc gtt cca gcg ctc tac atc atg 1411 Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro Ala Leu Tyr Ile Met 425 430 435 ttc ttc tct gca atc gca ggt gtg gcg ctg ctg ttc atg acc gag tct 1459 Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu Phe Met Thr Glu Ser 440 445 450 tca cag aag cca ctg ctt ggc tca ttc cca acc gtg gaa acc aag tct 1507 Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr Val Glu Thr Lys Ser 455 460 465 gag gcc gtg gag atc gtg aag aac cag gac gag gat cca aat att gat 1555 Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu Asp Pro Asn Ile Asp 470 475 480 485 ctt tcc cat atg ccg ttt cct gat gag gaa aac gta ggt gct gaa aag 1603 Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn Val Gly Ala Glu Lys 490 495 500 caa aac gca taaccgtaaa gcccgctgca aggcgggctt 1642 Gln Asn Ala <210> 88 <211> 504 <212> PRT <213> Corynebacterium glutamicum <400> 88 Val Ser Pro Ile Arg Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu 1 5 10 15 Thr Val Asp Asp Val Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala 20 25 30 Ile Lys Gly Thr Val Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly 35 40 45 Ile Tyr Gly Tyr Leu Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly 50 55 60 Leu Pro Gln Glu Trp Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val 65 70 75 80 Ser Tyr Leu Val Arg Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly 85 90 95 Asp Lys Val Gly Arg Gln Lys Val Leu Tyr Val Thr Met Ala Met Met 100 105 110 Ala Val Ser Thr Ala Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile 115 120 125 Gly Ala Trp Ala Leu Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly 130 135 140 Phe Ser Thr Gly Gly Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu 145 150 155 160 Phe Ala Pro Asp Arg Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met 165 170 175 Gly Ser Tyr Leu Gly Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr 180 185 190 Thr Trp Val Thr Thr His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe 195 200 205 Gly Trp Arg Ile Pro Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala 210 215 220 Val Tyr Leu Arg Thr Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn 225 230 235 240 Gln Asp Glu Pro Asn Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr 245 250 255 Ala Arg Leu Gly Leu Ala Gly Val Ile Arg His His Trp Arg Pro Leu 260 265 270 Leu Ile Gly Ile Ala Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala 275 280 285 Leu Thr Ser Tyr Met Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His 290 295 300 Ser Ala Ser Ala Ala Ala Val Thr Val Pro Ile Leu Val Val Met Ser 305 310 315 320 Leu Leu Leu Pro Phe Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys 325 330 335 Pro Val Tyr Ala Thr Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro 340 345 350 Ala Phe Leu Ile Met Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala 355 360 365 Leu Ser Met Val Ala Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala 370 375 380 Ser Ala Leu Pro Ala Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met 385 390 395 400 Gly Ile Ser Tyr Asn Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro 405 410 415 Leu Ile Thr Gln Phe Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro 420 425 430 Ala Leu Tyr Ile Met Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu 435 440 445 Phe Met Thr Glu Ser Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr 450 455 460 Val Glu Thr Lys Ser Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu 465 470 475 480 Asp Pro Asn Ile Asp Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn 485 490 495 Val Gly Ala Glu Lys Gln Asn Ala 500 <210> 89 <211> 1498 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1468) <223> RXA01667 <400> 89 attgcgcccc aaaacccgcg cactagaacg caaaacaaaa accagtaagg ctgaacccgg 60 ccgaatgtaa ctgaatctca aaaaagattt ctatgaagaa gtg gaa gga agt gct 115 Val Glu Gly Ser Ala 1 5 tta ggt atg gag tac aca ccg ttt agt ctg att ctc gat gtg ggg tgg 163 Leu Gly Met Glu Tyr Thr Pro Phe Ser Leu Ile Leu Asp Val Gly Trp 10 15 20 atc tcg ggg ttg atg atc atc ggc aat atc atg cgc cgg aag att ccg 211 Ile Ser Gly Leu Met Ile Ile Gly Asn Ile Met Arg Arg Lys Ile Pro 25 30 35 ttt ttc cag act ttg ctc att cct tcc tct att act gct ggc atc atc 259 Phe Phe Gln Thr Leu Leu Ile Pro Ser Ser Ile Thr Ala Gly Ile Ile 40 45 50 ggc atg att ttg ggg cct aag gtg ttg ggt ctg att ggt tgg tcg gat 307 Gly Met Ile Leu Gly Pro Lys Val Leu Gly Leu Ile Gly Trp Ser Asp 55 60 65 cat ctt tcc act tac act acg gtg ctc att gcg att gtg ttt gct tcg 355 His Leu Ser Thr Tyr Thr Thr Val Leu Ile Ala Ile Val Phe Ala Ser 70 75 80 85 atg ccg tat tcg atg aag ttt gac cgt ggc gtg cgt act ggc atg aag 403 Met Pro Tyr Ser Met Lys Phe Asp Arg Gly Val Arg Thr Gly Met Lys 90 95 100 acg atg tgg gcg tat tcg act gcg atg ttt gtg ggg cag tgg ggt ctg 451 Thr Met Trp Ala Tyr Ser Thr Ala Met Phe Val Gly Gln Trp Gly Leu 105 110 115 ttc att ttg ctg ggt ctg ttt ttg ttc cag ccg gtg tgg ggt acc gat 499 Phe Ile Leu Leu Gly Leu Phe Leu Phe Gln Pro Val Trp Gly Thr Asp 120 125 130 gag tgg ttc ggc atg atg ttg ccg gtt ggt ttt gtt ggt ggt ttt ggt 547 Glu Trp Phe Gly Met Met Leu Pro Val Gly Phe Val Gly Gly Phe Gly 135 140 145 act gct gct gcg gtg ggt act gcg ttg gag tct tcg ggt gcg gag gct 595 Thr Ala Ala Ala Val Gly Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala 150 155 160 165 gcg atg tct ttg ggc ttt acc tct gcg acg gtg ggt act ttt gct gcg 643 Ala Met Ser Leu Gly Phe Thr Ser Ala Thr Val Gly Thr Phe Ala Ala 170 175 180 att gtt ggt gga att att ttc aca acg tgg ggt att aag aag ggc aag 691 Ile Val Gly Gly Ile Ile Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys 185 190 195 act gcg gcg atg cct gcg cag ttg ccg tgg gat ttg cgt tcg ggt tat 739 Thr Ala Ala Met Pro Ala Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr 200 205 210 atc gat aag ctg agt gat cgt ccg tcg att ggt aag gcg agt acg aat 787 Ile Asp Lys Leu Ser Asp Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn 215 220 225 ccg tct gcg att gag cct ttg gcg ctg cat act ggc att att ttg ttg 835 Pro Ser Ala Ile Glu Pro Leu Ala Leu His Thr Gly Ile Ile Leu Leu 230 235 240 245 act gtt gcg gtt gcg tat tcc att aat cag tgg ttg ggt agc atg ttc 883 Thr Val Ala Val Ala Tyr Ser Ile Asn Gln Trp Leu Gly Ser Met Phe 250 255 260 cca acc gtg cag att ccg ttg ttt gcg atg tca ttt gtg gtc ggc att 931 Pro Thr Val Gln Ile Pro Leu Phe Ala Met Ser Phe Val Val Gly Ile 265 270 275 gtg ggc atg gga att atg cgt ttg ttg aag aag cct gag tat ttg gat 979 Val Gly Met Gly Ile Met Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp 280 285 290 cgc gac acc gtg aat tcc gtg tcg ggc gcg gcg acg gat tac ctc att 1027 Arg Asp Thr Val Asn Ser Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile 295 300 305 gcg ttt ggt att gcc tcg att gct cct gct gcg att gct gat tac tgg 1075 Ala Phe Gly Ile Ala Ser Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp 310 315 320 325 gtt cct ctt gtg gtg ctg ttt gtt ttg ggc acc atc tac tgt tgt ttc 1123 Val Pro Leu Val Val Leu Phe Val Leu Gly Thr Ile Tyr Cys Cys Phe 330 335 340 ttc ttt ttc tgg gtt gcg cct cgt ttc ttt ggc gag aag tgg ctg gag 1171 Phe Phe Phe Trp Val Ala Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu 345 350 355 cgc gcg atc ttc ggt tgg ggt tgg gct act gcc gcg gtt gct acc ggt 1219 Arg Ala Ile Phe Gly Trp Gly Trp Ala Thr Ala Ala Val Ala Thr Gly 360 365 370 atc gcg ttg ctg aag atc gtg gat ccg aag ttg aag tcg gga gcg ctt 1267 Ile Ala Leu Leu Lys Ile Val Asp Pro Lys Leu Lys Ser Gly Ala Leu 375 380 385 aat gag tac ggc gtg gct tat atc ggt ttt gct cca ttt gaa atc ggc 1315 Asn Glu Tyr Gly Val Ala Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly 390 395 400 405 atg acc atc atc gcg ccg atc gcg gtg ctc gca ggc ttt acc atg ggg 1363 Met Thr Ile Ile Ala Pro Ile Ala Val Leu Ala Gly Phe Thr Met Gly 410 415 420 ttg ggt tgg gcg tcg ttg att gtt gcg atc gtg att ttt ggc ctc gcg 1411 Leu Gly Trp Ala Ser Leu Ile Val Ala Ile Val Ile Phe Gly Leu Ala 425 430 435 tgg ggt ctg aag tgg ttg ccg gag cgc gga cat gtc cgc ggc gag ggt 1459 Trp Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly 440 445 450 aag ccg caa taaaggttgg aagcgccggg tctaggtccg 1498 Lys Pro Gln 455 <210> 90 <211> 456 <212> PRT <213> Corynebacterium glutamicum <400> 90 Val Glu Gly Ser Ala Leu Gly Met Glu Tyr Thr Pro Phe Ser Leu Ile 1 5 10 15 Leu Asp Val Gly Trp Ile Ser Gly Leu Met Ile Ile Gly Asn Ile Met 20 25 30 Arg Arg Lys Ile Pro Phe Phe Gln Thr Leu Leu Ile Pro Ser Ser Ile 35 40 45 Thr Ala Gly Ile Ile Gly Met Ile Leu Gly Pro Lys Val Leu Gly Leu 50 55 60 Ile Gly Trp Ser Asp His Leu Ser Thr Tyr Thr Thr Val Leu Ile Ala 65 70 75 80 Ile Val Phe Ala Ser Met Pro Tyr Ser Met Lys Phe Asp Arg Gly Val 85 90 95 Arg Thr Gly Met Lys Thr Met Trp Ala Tyr Ser Thr Ala Met Phe Val 100 105 110 Gly Gln Trp Gly Leu Phe Ile Leu Leu Gly Leu Phe Leu Phe Gln Pro 115 120 125 Val Trp Gly Thr Asp Glu Trp Phe Gly Met Met Leu Pro Val Gly Phe 130 135 140 Val Gly Gly Phe Gly Thr Ala Ala Ala Val Gly Thr Ala Leu Glu Ser 145 150 155 160 Ser Gly Ala Glu Ala Ala Met Ser Leu Gly Phe Thr Ser Ala Thr Val 165 170 175 Gly Thr Phe Ala Ala Ile Val Gly Gly Ile Ile Phe Thr Thr Trp Gly 180 185 190 Ile Lys Lys Gly Lys Thr Ala Ala Met Pro Ala Gln Leu Pro Trp Asp 195 200 205 Leu Arg Ser Gly Tyr Ile Asp Lys Leu Ser Asp Arg Pro Ser Ile Gly 210 215 220 Lys Ala Ser Thr Asn Pro Ser Ala Ile Glu Pro Leu Ala Leu His Thr 225 230 235 240 Gly Ile Ile Leu Leu Thr Val Ala Val Ala Tyr Ser Ile Asn Gln Trp 245 250 255 Leu Gly Ser Met Phe Pro Thr Val Gln Ile Pro Leu Phe Ala Met Ser 260 265 270 Phe Val Val Gly Ile Val Gly Met Gly Ile Met Arg Leu Leu Lys Lys 275 280 285 Pro Glu Tyr Leu Asp Arg Asp Thr Val Asn Ser Val Ser Gly Ala Ala 290 295 300 Thr Asp Tyr Leu Ile Ala Phe Gly Ile Ala Ser Ile Ala Pro Ala Ala 305 310 315 320 Ile Ala Asp Tyr Trp Val Pro Leu Val Val Leu Phe Val Leu Gly Thr 325 330 335 Ile Tyr Cys Cys Phe Phe Phe Phe Trp Val Ala Pro Arg Phe Phe Gly 340 345 350 Glu Lys Trp Leu Glu Arg Ala Ile Phe Gly Trp Gly Trp Ala Thr Ala 355 360 365 Ala Val Ala Thr Gly Ile Ala Leu Leu Lys Ile Val Asp Pro Lys Leu 370 375 380 Lys Ser Gly Ala Leu Asn Glu Tyr Gly Val Ala Tyr Ile Gly Phe Ala 385 390 395 400 Pro Phe Glu Ile Gly Met Thr Ile Ile Ala Pro Ile Ala Val Leu Ala 405 410 415 Gly Phe Thr Met Gly Leu Gly Trp Ala Ser Leu Ile Val Ala Ile Val 420 425 430 Ile Phe Gly Leu Ala Trp Gly Leu Lys Trp Leu Pro Glu Arg Gly His 435 440 445 Val Arg Gly Glu Gly Lys Pro Gln 450 455 <210> 91 <211> 874 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(844) <223> RXA01677 <400> 91 gtcgccatag ttgagtttta ttcatggctt ttagctaggc gactttagtt gagggctttt 60 agttgagggc ttcccagcag ggatggttaa ggagaattca gtg aac caa cag agt 115 Val Asn Gln Gln Ser 1 5 aaa aag tgg ctc gta ccg aca ctg gtc gtc atc att gca gtg ctc ctc 163 Lys Lys Trp Leu Val Pro Thr Leu Val Val Ile Ile Ala Val Leu Leu 10 15 20 atc gca gtt gtt ctg ttg atg tac cga gga aat gcg agt gat acg gcc 211 Ile Ala Val Val Leu Leu Met Tyr Arg Gly Asn Ala Ser Asp Thr Ala 25 30 35 gag ggc gtt tca gcc gct gcg act tcg gac tcg gct gct gct tcg act 259 Glu Gly Val Ser Ala Ala Ala Thr Ser Asp Ser Ala Ala Ala Ser Thr 40 45 50 gct gct tcg ggt tcc gct tct ggt gct gcg gac tcc gat ctg acc agc 307 Ala Ala Ser Gly Ser Ala Ser Gly Ala Ala Asp Ser Asp Leu Thr Ser 55 60 65 gtg gaa gca cgc gac cct tcc gac cct gtt gcg gtg gga gac gtt gat 355 Val Glu Ala Arg Asp Pro Ser Asp Pro Val Ala Val Gly Asp Val Asp 70 75 80 85 gca cct gtt ggg tta gtg gtg ttt tcc gac tac caa tgc ccg ttc tgt 403 Ala Pro Val Gly Leu Val Val Phe Ser Asp Tyr Gln Cys Pro Phe Cys 90 95 100 gca aag tgg agc gat gaa acc ctg cca cag atg atg aag cat gtg gaa 451 Ala Lys Trp Ser Asp Glu Thr Leu Pro Gln Met Met Lys His Val Glu 105 110 115 gat gga aac ctc cgc att gaa tgg cgt gaa gtg aac atc ttt gga gaa 499 Asp Gly Asn Leu Arg Ile Glu Trp Arg Glu Val Asn Ile Phe Gly Glu 120 125 130 cca tct gag cgt gga gct cgc gcg gca tac gct gcg ggt ttg cag gac 547 Pro Ser Glu Arg Gly Ala Arg Ala Ala Tyr Ala Ala Gly Leu Gln Asp 135 140 145 gca tac ttg gaa tac cac aac gca ctc ttt gcc aac ggt gaa aaa ccc 595 Ala Tyr Leu Glu Tyr His Asn Ala Leu Phe Ala Asn Gly Glu Lys Pro 150 155 160 165 agc gaa gac ctg ctc agc gaa gag gga ctt att aag ctt gct ggt gac 643 Ser Glu Asp Leu Leu Ser Glu Glu Gly Leu Ile Lys Leu Ala Gly Asp 170 175 180 ctt gga cta gac gaa tcg aaa ttc act gcc gat ttc caa tcc cct gaa 691 Leu Gly Leu Asp Glu Ser Lys Phe Thr Ala Asp Phe Gln Ser Pro Glu 185 190 195 act gca gtc gca att gcg caa cat caa cag ctg gga atc gat ctt ggc 739 Thr Ala Val Ala Ile Ala Gln His Gln Gln Leu Gly Ile Asp Leu Gly 200 205 210 gcc tac tcc acc cca gct ttc ctc cta ggt ggc cag cca atc atg ggc 787 Ala Tyr Ser Thr Pro Ala Phe Leu Leu Gly Gly Gln Pro Ile Met Gly 215 220 225 gct cag cct gct tct gta ttt gaa gcc gcc ttc gag caa gca ctg gca 835 Ala Gln Pro Ala Ser Val Phe Glu Ala Ala Phe Glu Gln Ala Leu Ala 230 235 240 245 gcg aaa gaa taaaccgtgg atgtcggcct agttacagct 874 Ala Lys Glu <210> 92 <211> 248 <212> PRT <213> Corynebacterium glutamicum <400> 92 Val Asn Gln Gln Ser Lys Lys Trp Leu Val Pro Thr Leu Val Val Ile 1 5 10 15 Ile Ala Val Leu Leu Ile Ala Val Val Leu Leu Met Tyr Arg Gly Asn 20 25 30 Ala Ser Asp Thr Ala Glu Gly Val Ser Ala Ala Ala Thr Ser Asp Ser 35 40 45 Ala Ala Ala Ser Thr Ala Ala Ser Gly Ser Ala Ser Gly Ala Ala Asp 50 55 60 Ser Asp Leu Thr Ser Val Glu Ala Arg Asp Pro Ser Asp Pro Val Ala 65 70 75 80 Val Gly Asp Val Asp Ala Pro Val Gly Leu Val Val Phe Ser Asp Tyr 85 90 95 Gln Cys Pro Phe Cys Ala Lys Trp Ser Asp Glu Thr Leu Pro Gln Met 100 105 110 Met Lys His Val Glu Asp Gly Asn Leu Arg Ile Glu Trp Arg Glu Val 115 120 125 Asn Ile Phe Gly Glu Pro Ser Glu Arg Gly Ala Arg Ala Ala Tyr Ala 130 135 140 Ala Gly Leu Gln Asp Ala Tyr Leu Glu Tyr His Asn Ala Leu Phe Ala 145 150 155 160 Asn Gly Glu Lys Pro Ser Glu Asp Leu Leu Ser Glu Glu Gly Leu Ile 165 170 175 Lys Leu Ala Gly Asp Leu Gly Leu Asp Glu Ser Lys Phe Thr Ala Asp 180 185 190 Phe Gln Ser Pro Glu Thr Ala Val Ala Ile Ala Gln His Gln Gln Leu 195 200 205 Gly Ile Asp Leu Gly Ala Tyr Ser Thr Pro Ala Phe Leu Leu Gly Gly 210 215 220 Gln Pro Ile Met Gly Ala Gln Pro Ala Ser Val Phe Glu Ala Ala Phe 225 230 235 240 Glu Gln Ala Leu Ala Ala Lys Glu 245 <210> 93 <211> 1408 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1378) <223> RXA01727 <400> 93 agcttttggt ggtttcacca cctgcgctcg tcttaatttt gcgtgttcca gagagaccct 60 tgaggagggg ctgcgccgta tcgccagcgt gttgtaaata atg agt aaa aag tct 115 Met Ser Lys Lys Ser 1 5 gtc ctg att act tct ttg atg ctg ttt tcc atg ttc ttc gga gct gga 163 Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met Phe Phe Gly Ala Gly 10 15 20 aac ctc atc ttc ccg ccg atg ctt gga ttg tcg gca gga acc aac tat 211 Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser Ala Gly Thr Asn Tyr 25 30 35 cta cca gct atc tta gga ttt cta gca acg agt gtt ctg ctc ccg gtg 259 Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser Val Leu Leu Pro Val 40 45 50 ctg gcg att atc gcg gtg gtg ttg tcg gga gaa aat gtc aag gac atg 307 Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu Asn Val Lys Asp Met 55 60 65 gct tct cgt ggc ggt aag atc ttt ggc ctg gtg ttt cct att gct gcc 355 Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val Phe Pro Ile Ala Ala 70 75 80 85 tat ttg tct atc ggc gcg ttt tac gcg ctg ccg agg act ggg gcg gtg 403 Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro Arg Thr Gly Ala Val 90 95 100 agc tat tcg acg gcg gtt ggc gtc gat aat gcg ctt tat tcg ggc ttg 451 Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala Leu Tyr Ser Gly Leu 105 110 115 ttt aac ttt gtg ttt ttt gcg gtg gca ctg gcg ttg tcg tgg aat ccg 499 Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala Leu Ser Trp Asn Pro 120 125 130 aat ggc att gca gac aag ttg ggt aag tgg ctc acg cca gcg ttg ctc 547 Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu Thr Pro Ala Leu Leu 135 140 145 acg ttg att gtg gtg ctg gtg gtg ttg tcg gta gcc aag ttg gat ggc 595 Thr Leu Ile Val Val Leu Val Val Leu Ser Val Ala Lys Leu Asp Gly 150 155 160 165 acg cca ggt gag cca agt agt gcg tat gcg cag cag cct gcg ggg gcg 643 Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln Gln Pro Ala Gly Ala 170 175 180 ggt ttg ctt gag ggc tac atg acg atg gat gcg att gct gcg ttg gcg 691 Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala Ile Ala Ala Leu Ala 185 190 195 ttt ggc atc gtg gtg att tct gcg ttc aag tac caa aag gtt aac aag 739 Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr Gln Lys Val Asn Lys 200 205 210 gtc cgc acg gca act gtc gtg tcg gcg ttc att gcc gga att ttg ttg 787 Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile Ala Gly Ile Leu Leu 215 220 225 gcg ctg gtt tat ctt ggt ttg ggc tca atc ggt caa gta gta aac ggt 835 Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly Gln Val Val Asn Gly 230 235 240 245 gag ttc gct gat ggc acc gca att ttg aac tac gct gca ctg tcc acg 883 Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr Ala Ala Leu Ser Thr 250 255 260 atg ggt cag gct ggt cgc atc atg ttc gtg gct att ttg atc ctt gca 931 Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala Ile Leu Ile Leu Ala 265 270 275 tgt atg acc acc gca gtt ggt ctg atc agt gcg acg tct gag ttt ttc 979 Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala Thr Ser Glu Phe Phe 280 285 290 aat tcg ctg ctg cca ggt gtc aag tac cac gtc tgg gcc act gtt ttc 1027 Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val Trp Ala Thr Val Phe 295 300 305 gcg ctg att tcc ttt ggc gtt gcc acc atg ggt ttg gat acg gtg ttg 1075 Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly Leu Asp Thr Val Leu 310 315 320 325 gcc gtt gcg gct cca gtg att agt ttc att tac cca tcg gcc atc acc 1123 Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr Pro Ser Ala Ile Thr 330 335 340 ttg gtg ttc ttg tcg ctc atc gag ccc ctg ctg ttc cgt ctc aag tgg 1171 Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu Phe Arg Leu Lys Trp 345 350 355 acc tac cta ttc ggc att tgg act gca gtt gtg tgg gcg ctg ttc atg 1219 Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val Trp Ala Leu Phe Met 360 365 370 tct atc cct gcg ctg aat cca ttc atc gaa tgg gcg ccg ctg cac agc 1267 Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp Ala Pro Leu His Ser 375 380 385 atg tct ttg ggt tgg gtt gtc cca gtt ctc gtg gcc tct gcc atc ggt 1315 Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala Ile Gly 390 395 400 405 ttg gct att gat tgg aac aag aaa ggt gcc cag tct gtt gca aag aag 1363 Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln Ser Val Ala Lys Lys 410 415 420 gaa tcc att tcc gtc taatcgctaa ttgcgaggag tctttgcatg 1408 Glu Ser Ile Ser Val 425 <210> 94 <211> 426 <212> PRT <213> Corynebacterium glutamicum <400> 94 Met Ser Lys Lys Ser Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met 1 5 10 15 Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser 20 25 30 Ala Gly Thr Asn Tyr Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser 35 40 45 Val Leu Leu Pro Val Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu 50 55 60 Asn Val Lys Asp Met Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val 65 70 75 80 Phe Pro Ile Ala Ala Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro 85 90 95 Arg Thr Gly Ala Val Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala 100 105 110 Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala 115 120 125 Leu Ser Trp Asn Pro Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu 130 135 140 Thr Pro Ala Leu Leu Thr Leu Ile Val Val Leu Val Val Leu Ser Val 145 150 155 160 Ala Lys Leu Asp Gly Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln 165 170 175 Gln Pro Ala Gly Ala Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala 180 185 190 Ile Ala Ala Leu Ala Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr 195 200 205 Gln Lys Val Asn Lys Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile 210 215 220 Ala Gly Ile Leu Leu Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly 225 230 235 240 Gln Val Val Asn Gly Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr 245 250 255 Ala Ala Leu Ser Thr Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala 260 265 270 Ile Leu Ile Leu Ala Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala 275 280 285 Thr Ser Glu Phe Phe Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val 290 295 300 Trp Ala Thr Val Phe Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly 305 310 315 320 Leu Asp Thr Val Leu Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr 325 330 335 Pro Ser Ala Ile Thr Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu 340 345 350 Phe Arg Leu Lys Trp Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val 355 360 365 Trp Ala Leu Phe Met Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp 370 375 380 Ala Pro Leu His Ser Met Ser Leu Gly Trp Val Val Pro Val Leu Val 385 390 395 400 Ala Ser Ala Ile Gly Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln 405 410 415 Ser Val Ala Lys Lys Glu Ser Ile Ser Val 420 425 <210> 95 <211> 910 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(880) <223> RXA01746 <400> 95 ctgcagctct aagatctctg caagttaaaa ccgccactcc cctttcactg gggagtggcg 60 gttttgtcgt ttcatgcatg cagtgtgtga cttatcaacc ttg tta ggg cta ggg 115 Leu Leu Gly Leu Gly 1 5 tgg ata tct atc atg act gca cca aga gat cct ttt ttc ccc gca gat 163 Trp Ile Ser Ile Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Ala Asp 10 15 20 ctt tct atc cgc gcg tct gca gag ccc att gaa att cag cgg ttg ggt 211 Leu Ser Ile Arg Ala Ser Ala Glu Pro Ile Glu Ile Gln Arg Leu Gly 25 30 35 ttg atc gat tat caa gag gcc tgg gat tat caa gca gag ctt gct acc 259 Leu Ile Asp Tyr Gln Glu Ala Trp Asp Tyr Gln Ala Glu Leu Ala Thr 40 45 50 cgt agg gct aat gat gaa atc cct gat cag ctg ctt att ttg gag cac 307 Arg Arg Ala Asn Asp Glu Ile Pro Asp Gln Leu Leu Ile Leu Glu His 55 60 65 ccg tcg gtg tat acc gca ggt aag cgc acc cag ccg gaa gat ctt ccc 355 Pro Ser Val Tyr Thr Ala Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro 70 75 80 85 acc aac gga ctg ccg gtg atc aat gct gat cgt ggt ggt cgc atc acg 403 Thr Asn Gly Leu Pro Val Ile Asn Ala Asp Arg Gly Gly Arg Ile Thr 90 95 100 tgg cat ggt cct ggc caa ttg gtg atc tat ccg atc atc aaa tta gcc 451 Trp His Gly Pro Gly Gln Leu Val Ile Tyr Pro Ile Ile Lys Leu Ala 105 110 115 gat ccg atc gat gtg gtt gat tac gta aga cgc ctc gag gaa gcg ctc 499 Asp Pro Ile Asp Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu 120 125 130 atc caa gtt gtc ggc gat atg ggt gtt gcc ggc gct ggg cgc att gat 547 Ile Gln Val Val Gly Asp Met Gly Val Ala Gly Ala Gly Arg Ile Asp 135 140 145 ggg cgt tcg ggt gtg tgg gtg cca gct cat gat ggt tgg gtg gac agc 595 Gly Arg Ser Gly Val Trp Val Pro Ala His Asp Gly Trp Val Asp Ser 150 155 160 165 aag gtt gcg gcc atc ggc att cga ata act cgt ggt gtt gca atg cac 643 Lys Val Ala Ala Ile Gly Ile Arg Ile Thr Arg Gly Val Ala Met His 170 175 180 ggt gtg gcc atc aac tgc aac aac acg ttg gat ttc tat gag cac atc 691 Gly Val Ala Ile Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His Ile 185 190 195 att ccg tgt ggc att gct gat gca ggc ttg agc aca ctc tcg agg gaa 739 Ile Pro Cys Gly Ile Ala Asp Ala Gly Leu Ser Thr Leu Ser Arg Glu 200 205 210 ctg aaa agg gac gtt tca gtt gag gaa tta gtc gag cca tcg atc cgc 787 Leu Lys Arg Asp Val Ser Val Glu Glu Leu Val Glu Pro Ser Ile Arg 215 220 225 gca ttg gat gat gct ttg gct ggt cgg ctg gtt gtt tct gat cat tct 835 Ala Leu Asp Asp Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser 230 235 240 245 ttc ggc agc gcg ccc gac cca act aag aat ctc cct aaa cgg ggg 880 Phe Gly Ser Ala Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly 250 255 260 tagtacgagg aattttgtcg gtggggcgcc 910 <210> 96 <211> 260 <212> PRT <213> Corynebacterium glutamicum <400> 96 Leu Leu Gly Leu Gly Trp Ile Ser Ile Met Thr Ala Pro Arg Asp Pro 1 5 10 15 Phe Phe Pro Ala Asp Leu Ser Ile Arg Ala Ser Ala Glu Pro Ile Glu 20 25 30 Ile Gln Arg Leu Gly Leu Ile Asp Tyr Gln Glu Ala Trp Asp Tyr Gln 35 40 45 Ala Glu Leu Ala Thr Arg Arg Ala Asn Asp Glu Ile Pro Asp Gln Leu 50 55 60 Leu Ile Leu Glu His Pro Ser Val Tyr Thr Ala Gly Lys Arg Thr Gln 65 70 75 80 Pro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val Ile Asn Ala Asp Arg 85 90 95 Gly Gly Arg Ile Thr Trp His Gly Pro Gly Gln Leu Val Ile Tyr Pro 100 105 110 Ile Ile Lys Leu Ala Asp Pro Ile Asp Val Val Asp Tyr Val Arg Arg 115 120 125 Leu Glu Glu Ala Leu Ile Gln Val Val Gly Asp Met Gly Val Ala Gly 130 135 140 Ala Gly Arg Ile Asp Gly Arg Ser Gly Val Trp Val Pro Ala His Asp 145 150 155 160 Gly Trp Val Asp Ser Lys Val Ala Ala Ile Gly Ile Arg Ile Thr Arg 165 170 175 Gly Val Ala Met His Gly Val Ala Ile Asn Cys Asn Asn Thr Leu Asp 180 185 190 Phe Tyr Glu His Ile Ile Pro Cys Gly Ile Ala Asp Ala Gly Leu Ser 195 200 205 Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu Leu Val 210 215 220 Glu Pro Ser Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg Leu Val 225 230 235 240 Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys Asn Leu 245 250 255 Pro Lys Arg Gly 260 <210> 97 <211> 1747 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1717) <223> RXA01749 <400> 97 ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60 taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg agc ttc ctt gta 115 Val Ser Phe Leu Val 1 5 gaa aat caa tta ctc gcg ttg gtt gtc atc atg acg gtc gga cta ttg 163 Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met Thr Val Gly Leu Leu 10 15 20 ctc ggc cgc atc aaa att ttc ggg ttc cgt ctc ggc gtc gcc gct gta 211 Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu Gly Val Ala Ala Val 25 30 35 ctg ttt gta ggt cta gcg cta tcc acc att gag ccg gat att tcc gtc 259 Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu Pro Asp Ile Ser Val 40 45 50 cca tcc ctc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg atc 307 Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr Ile 55 60 65 ggt ctg gaa gcc ggc cct gga ttc ttc acc tcc atg aaa acc act ggt 355 Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser Met Lys Thr Thr Gly 70 75 80 85 ctg cgc aac aac gca ctg acc ttg ggc gcc atc atc gcc acc acg gca 403 Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile Ile Ala Thr Thr Ala 90 95 100 ctc gca tgg gca ctc atc aca gtt ttg aac atc gat gcc gcc tcc ggc 451 Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile Asp Ala Ala Ser Gly 105 110 115 gcc ggc atg ctc acc ggc gcg ctc acc aac acc cca gcc atg gcc gca 499 Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Ala Met Ala Ala 120 125 130 gtt gtt gac gca ctt cct tcg ctt atc gac gac acc ggc cag ctt cac 547 Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp Thr Gly Gln Leu His 135 140 145 ctc atc gcc gag ctg ccc gtc gtc gca tat tcc ttg gca tac ccc ctc 595 Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser Leu Ala Tyr Pro Leu 150 155 160 165 ggt gtg ctc atc gtt att ctc tcc atc gcc atc ttc agc tct gtg ttc 643 Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile Phe Ser Ser Val Phe 170 175 180 aaa gtc gac cac aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691 Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala Gly Val Ala Val Gln 185 190 195 gaa ctc aaa ggc cgt cgc atc cgc gtc acc gtc gct gat ctt cca gcc 739 Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val Ala Asp Leu Pro Ala 200 205 210 ctg gag aac atc cca gag ctg ctc aac ctc cac gtc att gtg tcc cga 787 Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His Val Ile Val Ser Arg 215 220 225 gtg gaa cga gac ggt gag caa ttc atc ccg ctt tat ggc gaa cac gca 835 Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu Tyr Gly Glu His Ala 230 235 240 245 cgc atc ggc gat gtc tta aca gtg gtg ggt gcc gat gaa gaa ctc aac 883 Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala Asp Glu Glu Leu Asn 250 255 260 cgc gcg gaa aaa gcc atc ggt gaa ctc att gac ggc gac ccc tac agc 931 Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp Gly Asp Pro Tyr Ser 265 270 275 aat gtg gaa ctt gat tac cga cgc atc ttc gtc tca aac aca gca gtc 979 Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val Ser Asn Thr Ala Val 280 285 290 gtg ggc act ccc cta tcc aag ctc cag cca ctg ttt aaa gac atg ctg 1027 Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu 295 300 305 atc acc cgc atc agg cgc ggc gac aca gat ttg gtg gcc tcc tcc gac 1075 Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu Val Ala Ser Ser Asp 310 315 320 325 atg act ttg cag ctc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123 Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Ala Pro Ala Glu 330 335 340 aaa ctc cgc gaa gca acc caa ttg ctc ggc gat tcc tac aag aaa ctc 1171 Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu 345 350 355 tcc gat ttc aac ctg ctc cca ctc gct gcc ggc ctc atg atc ggt gtg 1219 Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly Leu Met Ile Gly Val 360 365 370 ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga agc tcc ctg aaa 1267 Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys 375 380 385 ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg ctc ggc atg 1315 Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala Leu Leu Leu Gly Met 390 395 400 405 atc aat cgc aca ggc aag ttc gtc tgg caa atc ccc tac gga gca aac 1363 Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile Pro Tyr Gly Ala Asn 410 415 420 ctt gcc ctt cgc caa ctg ggc atc aca cta ttt ttg gct gcc atc ggt 1411 Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe Leu Ala Ala Ile Gly 425 430 435 acc tca gcg ggc gca gga ttt cga tca gcg atc agc gac ccc caa tca 1459 Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile Ser Asp Pro Gln Ser 440 445 450 ctc acc atc atc ggc ttc ggt gcg ctg ctc act ttg ttc atc tcc atc 1507 Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr Leu Phe Ile Ser Ile 455 460 465 acg gtg ctg ttc gtt ggc cac aaa ctg atg aaa atc ccc ttc ggt gaa 1555 Thr Val Leu Phe Val Gly His Lys Leu Met Lys Ile Pro Phe Gly Glu 470 475 480 485 acc gct ggc atc ctc gcc ggt acg caa acc cac cct gct gtg ctg agt 1603 Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His Pro Ala Val Leu Ser 490 495 500 tat gtg tca gat gcc tcc cgc aac gag ctc cct gcc atg ggt tat acc 1651 Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro Ala Met Gly Tyr Thr 505 510 515 tct gtg tat ccg ctg gcg atg atc gca aag atc ctg gcc gcc caa acg 1699 Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile Leu Ala Ala Gln Thr 520 525 530 ttg ttg ttc cta ctt atc tagcattgac cccttaagcg cagaaggcga 1747 Leu Leu Phe Leu Leu Ile 535 <210> 98 <211> 539 <212> PRT <213> Corynebacterium glutamicum <400> 98 Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met 1 5 10 15 Thr Val Gly Leu Leu Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu 20 25 30 Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu 35 40 45 Pro Asp Ile Ser Val Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu 50 55 60 Phe Val Tyr Thr Ile Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser 65 70 75 80 Met Lys Thr Thr Gly Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile 85 90 95 Ile Ala Thr Thr Ala Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile 100 105 110 Asp Ala Ala Ser Gly Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr 115 120 125 Pro Ala Met Ala Ala Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp 130 135 140 Thr Gly Gln Leu His Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser 145 150 155 160 Leu Ala Tyr Pro Leu Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile 165 170 175 Phe Ser Ser Val Phe Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala 180 185 190 Gly Val Ala Val Gln Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val 195 200 205 Ala Asp Leu Pro Ala Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His 210 215 220 Val Ile Val Ser Arg Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu 225 230 235 240 Tyr Gly Glu His Ala Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala 245 250 255 Asp Glu Glu Leu Asn Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp 260 265 270 Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val 275 280 285 Ser Asn Thr Ala Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu 290 295 300 Phe Lys Asp Met Leu Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu 305 310 315 320 Val Ala Ser Ser Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val 325 330 335 Val Ala Pro Ala Glu Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp 340 345 350 Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly 355 360 365 Leu Met Ile Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly 370 375 380 Gly Ser Ser Leu Lys Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala 385 390 395 400 Leu Leu Leu Gly Met Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile 405 410 415 Pro Tyr Gly Ala Asn Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe 420 425 430 Leu Ala Ala Ile Gly Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile 435 440 445 Ser Asp Pro Gln Ser Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr 450 455 460 Leu Phe Ile Ser Ile Thr Val Leu Phe Val Gly His Lys Leu Met Lys 465 470 475 480 Ile Pro Phe Gly Glu Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His 485 490 495 Pro Ala Val Leu Ser Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro 500 505 510 Ala Met Gly Tyr Thr Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile 515 520 525 Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu Ile 530 535 <210> 99 <211> 1147 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1117) <223> RXA01822 <400> 99 gcgctgtcgc catcggaaag ataggcaact gcaaggctta accgggtgcg tgttctccag 60 gtgctgatgt ttagccctgt ttcatcgaga aaacggcgct gtg aaa aga aac cag 115 Val Lys Arg Asn Gln 1 5 acg att cgg gtt gca aag ctt tct gtg cag ttc cgt ccc cgg aca ctg 163 Thr Ile Arg Val Ala Lys Leu Ser Val Gln Phe Arg Pro Arg Thr Leu 10 15 20 atg gta gtg ctc atc gcg gtt acg ttg gtg gtg att ctt att cat ttg 211 Met Val Val Leu Ile Ala Val Thr Leu Val Val Ile Leu Ile His Leu 25 30 35 agt ctg act gtt ggt tcc atc act gca tcg cag gcg tgg tcg gcg gtc 259 Ser Leu Thr Val Gly Ser Ile Thr Ala Ser Gln Ala Trp Ser Ala Val 40 45 50 gta gga gtg ggt gat gct tct gat att cgt tca gtg caa tca cgg cgc 307 Val Gly Val Gly Asp Ala Ser Asp Ile Arg Ser Val Gln Ser Arg Arg 55 60 65 ttg cct cga gtg ctg aca gcg gta gga gtg ggc gct gcg ctg gga tta 355 Leu Pro Arg Val Leu Thr Ala Val Gly Val Gly Ala Ala Leu Gly Leu 70 75 80 85 tct ggc gct tgt ttc agt ccg tgt cac gta aca gtg ctg ggc tca cca 403 Ser Gly Ala Cys Phe Ser Pro Cys His Val Thr Val Leu Gly Ser Pro 90 95 100 gac atc att gga ttt acc acg gga gct gcc aca gct gcg gcg atc agc 451 Asp Ile Ile Gly Phe Thr Thr Gly Ala Ala Thr Ala Ala Ala Ile Ser 105 110 115 att att ttc ttt gat gca ggt gtg gtc tta acc gga gtg gca gcc att 499 Ile Ile Phe Phe Asp Ala Gly Val Val Leu Thr Gly Val Ala Ala Ile 120 125 130 ctt ggt gga ctt gcg acc gca gtt ttt gtc tat ctc atg gcc aga caa 547 Leu Gly Gly Leu Ala Thr Ala Val Phe Val Tyr Leu Met Ala Arg Gln 135 140 145 aat agc aat acc ggc ggg ttg cgt ctg gtg ttg gtt ggt atc gga aca 595 Asn Ser Asn Thr Gly Gly Leu Arg Leu Val Leu Val Gly Ile Gly Thr 150 155 160 165 ggt gca ttt ttg ggt gct gct cgt gat ttc ttc atg gtg cgc gca gat 643 Gly Ala Phe Leu Gly Ala Ala Arg Asp Phe Phe Met Val Arg Ala Asp 170 175 180 att acg ggt gct tcg acg gta cag ctg tgg tct gcc ggt tcg ttg agc 691 Ile Thr Gly Ala Ser Thr Val Gln Leu Trp Ser Ala Gly Ser Leu Ser 185 190 195 ggg cgc gac tgg aat cat gcc ctg ttg gtg ttg att tcg tgt gca gtg 739 Gly Arg Asp Trp Asn His Ala Leu Leu Val Leu Ile Ser Cys Ala Val 200 205 210 att gtg cca gca ctg tgc att att gtc cgc cgt tta cgc ctg atg gaa 787 Ile Val Pro Ala Leu Cys Ile Ile Val Arg Arg Leu Arg Leu Met Glu 215 220 225 atg ggt gat gat gca gct ggg gca ctt gga att tca gtg gag aga aca 835 Met Gly Asp Asp Ala Ala Gly Ala Leu Gly Ile Ser Val Glu Arg Thr 230 235 240 245 cgg ttg ata gcc att ttg ttg gct gtg ctg ctg gtg ggg atc gcc acc 883 Arg Leu Ile Ala Ile Leu Leu Ala Val Leu Leu Val Gly Ile Ala Thr 250 255 260 gca gct gca ggt ccc atc gct ttt att gca ctg gca gca cct cag att 931 Ala Ala Ala Gly Pro Ile Ala Phe Ile Ala Leu Ala Ala Pro Gln Ile 265 270 275 gcc cgg gct ctg gcc cgg gag gat gga gtg ctg gtg gct gcg tcg ata 979 Ala Arg Ala Leu Ala Arg Glu Asp Gly Val Leu Val Ala Ala Ser Ile 280 285 290 agc att ggc tct ggg ctg tta gtt gcg gcg gat tgc cta gag caa cac 1027 Ser Ile Gly Ser Gly Leu Leu Val Ala Ala Asp Cys Leu Glu Gln His 295 300 305 gtt gat act gag ctg cac acg ccc gtt ggc ctg gtg acc agt ttg ctg 1075 Val Asp Thr Glu Leu His Thr Pro Val Gly Leu Val Thr Ser Leu Leu 310 315 320 325 ggc ggg gtg tat ttg atg tgg ctt ttg agc cga aag gag gca 1117 Gly Gly Val Tyr Leu Met Trp Leu Leu Ser Arg Lys Glu Ala 330 335 taaatgctgc aagcgcatga tctcacgctg 1147 <210> 100 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 100 Val Lys Arg Asn Gln Thr Ile Arg Val Ala Lys Leu Ser Val Gln Phe 1 5 10 15 Arg Pro Arg Thr Leu Met Val Val Leu Ile Ala Val Thr Leu Val Val 20 25 30 Ile Leu Ile His Leu Ser Leu Thr Val Gly Ser Ile Thr Ala Ser Gln 35 40 45 Ala Trp Ser Ala Val Val Gly Val Gly Asp Ala Ser Asp Ile Arg Ser 50 55 60 Val Gln Ser Arg Arg Leu Pro Arg Val Leu Thr Ala Val Gly Val Gly 65 70 75 80 Ala Ala Leu Gly Leu Ser Gly Ala Cys Phe Ser Pro Cys His Val Thr 85 90 95 Val Leu Gly Ser Pro Asp Ile Ile Gly Phe Thr Thr Gly Ala Ala Thr 100 105 110 Ala Ala Ala Ile Ser Ile Ile Phe Phe Asp Ala Gly Val Val Leu Thr 115 120 125 Gly Val Ala Ala Ile Leu Gly Gly Leu Ala Thr Ala Val Phe Val Tyr 130 135 140 Leu Met Ala Arg Gln Asn Ser Asn Thr Gly Gly Leu Arg Leu Val Leu 145 150 155 160 Val Gly Ile Gly Thr Gly Ala Phe Leu Gly Ala Ala Arg Asp Phe Phe 165 170 175 Met Val Arg Ala Asp Ile Thr Gly Ala Ser Thr Val Gln Leu Trp Ser 180 185 190 Ala Gly Ser Leu Ser Gly Arg Asp Trp Asn His Ala Leu Leu Val Leu 195 200 205 Ile Ser Cys Ala Val Ile Val Pro Ala Leu Cys Ile Ile Val Arg Arg 210 215 220 Leu Arg Leu Met Glu Met Gly Asp Asp Ala Ala Gly Ala Leu Gly Ile 225 230 235 240 Ser Val Glu Arg Thr Arg Leu Ile Ala Ile Leu Leu Ala Val Leu Leu 245 250 255 Val Gly Ile Ala Thr Ala Ala Ala Gly Pro Ile Ala Phe Ile Ala Leu 260 265 270 Ala Ala Pro Gln Ile Ala Arg Ala Leu Ala Arg Glu Asp Gly Val Leu 275 280 285 Val Ala Ala Ser Ile Ser Ile Gly Ser Gly Leu Leu Val Ala Ala Asp 290 295 300 Cys Leu Glu Gln His Val Asp Thr Glu Leu His Thr Pro Val Gly Leu 305 310 315 320 Val Thr Ser Leu Leu Gly Gly Val Tyr Leu Met Trp Leu Leu Ser Arg 325 330 335 Lys Glu Ala <210> 101 <211> 769 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(739) <223> RXA01853 <400> 101 gaatgtccaa cgtcaaaaaa attcttttct atcctaaccg tatcttcaca ccttgaggga 60 atgatggggg agcgccgctt acgcactaca ctgtttattc atg gag atc ctc gga 115 Met Glu Ile Leu Gly 1 5 ttc gcg gct ggt ccg tat aaa aca aat tgc tat gtg gtg cgc ggg gag 163 Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr Val Val Arg Gly Glu 10 15 20 aat gag gtc gcg atc att gat cct ggc atg cat gcc cac gat gat ttg 211 Asn Glu Val Ala Ile Ile Asp Pro Gly Met His Ala His Asp Asp Leu 25 30 35 gtg gaa tac atc acc acg aat aat ttg agc gtg gac aag att gtg ctc 259 Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val Asp Lys Ile Val Leu 40 45 50 acc cac gga cac att gat cac acc cgt gat gct ggt gtt gtg gca aag 307 Thr His Gly His Ile Asp His Thr Arg Asp Ala Gly Val Val Ala Lys 55 60 65 cgt ttc aat gcg ccg gtc tat atc cat cct gat gat gcg ttt ttc ctt 355 Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp Asp Ala Phe Phe Leu 70 75 80 85 gag gtc tac aag gga tct gga aca aag acg gcc atg ctt ttc gac gcc 403 Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala Met Leu Phe Asp Ala 90 95 100 gac aac atg gtg tcc cct gat cct gag tca ctg cgt gat ctg gtt gat 451 Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu Arg Asp Leu Val Asp 105 110 115 ggt gag aca atc act ttg gct ggc gaa gaa ttc acg ttg aag cat gca 499 Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe Thr Leu Lys His Ala 120 125 130 cca ggg cat tca cct ggt tgt acg ctg atc gtc ggc aag gaa tac tgc 547 Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val Gly Lys Glu Tyr Cys 135 140 145 ttt agc ggt gat gtg ttg ttc aag ggc tct att ggt cgc act gat ttt 595 Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile Gly Arg Thr Asp Phe 150 155 160 165 gag tgg tct gat gca gat gcc atg aat gag tca cta cgc acg gca gtg 643 Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser Leu Arg Thr Ala Val 170 175 180 ctc cca ctt gat gat gca ttg cag att ctt cct ggg cat ggc cca acc 691 Leu Pro Leu Asp Asp Ala Leu Gln Ile Leu Pro Gly His Gly Pro Thr 185 190 195 acc acc atg cgt gca gaa cgc act ggt aac cct ttc ttg ctg gca ctg 739 Thr Thr Met Arg Ala Glu Arg Thr Gly Asn Pro Phe Leu Leu Ala Leu 200 205 210 tagggctaag ttccgtacta cttcttcgaa 769 <210> 102 <211> 213 <212> PRT <213> Corynebacterium glutamicum <400> 102 Met Glu Ile Leu Gly Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr 1 5 10 15 Val Val Arg Gly Glu Asn Glu Val Ala Ile Ile Asp Pro Gly Met His 20 25 30 Ala His Asp Asp Leu Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val 35 40 45 Asp Lys Ile Val Leu Thr His Gly His Ile Asp His Thr Arg Asp Ala 50 55 60 Gly Val Val Ala Lys Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp 65 70 75 80 Asp Ala Phe Phe Leu Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala 85 90 95 Met Leu Phe Asp Ala Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu 100 105 110 Arg Asp Leu Val Asp Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe 115 120 125 Thr Leu Lys His Ala Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val 130 135 140 Gly Lys Glu Tyr Cys Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile 145 150 155 160 Gly Arg Thr Asp Phe Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser 165 170 175 Leu Arg Thr Ala Val Leu Pro Leu Asp Asp Ala Leu Gln Ile Leu Pro 180 185 190 Gly His Gly Pro Thr Thr Thr Met Arg Ala Glu Arg Thr Gly Asn Pro 195 200 205 Phe Leu Leu Ala Leu 210 <210> 103 <211> 1402 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1372) <223> RXA01936 <400> 103 gcgcggtgac accacagccg ttgtcagcgg cgcttggtct gtggaggatc gccgaggtta 60 ctaacaaata ggcccaacaa agaggtctaa gctctacctg gtg agt ttc cga gat 115 Val Ser Phe Arg Asp 1 5 att ttc gct gac acc aga ccg ctg aaa gaa ccg gcc ttc aaa cgc ctc 163 Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro Ala Phe Lys Arg Leu 10 15 20 tgg ctt ggc aat gtt gcc acc gtc att ggt gcc caa tta act gtt gtt 211 Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala Gln Leu Thr Val Val 25 30 35 gcc gtt ccg gtg cag att tac caa atg act ggg tcc tcc ggc tat gtg 259 Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly Ser Ser Gly Tyr Val 40 45 50 ggc ttg acc ggg ctt ttt ggc ctt att cct ttg gtt att ttt ggc ctt 307 Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu Val Ile Phe Gly Leu 55 60 65 tat ggt gga tcc att gcg gat gct ttt gat aaa cgc atc gtg ctg atc 355 Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys Arg Ile Val Leu Ile 70 75 80 85 tgc acc acg atc ggc atg tgt gtc acc act gcc ggt ttt tgg gtg ctg 403 Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala Gly Phe Trp Val Leu 90 95 100 acc att tta ggc aat gag aat att tgg ctc ctg tta ata aac ttt tct 451 Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu Leu Ile Asn Phe Ser 105 110 115 tta cag cag gca ttt ttc gcg gtg aat caa ccc acc cga acg gcg atc 499 Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro Thr Arg Thr Ala Ile 120 125 130 ctt cga agt att ttg ccg att gat caa tta gcg tcg gca aca tca ctg 547 Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala Ser Ala Thr Ser Leu 135 140 145 aat atg ctg ctc atg cag acc ggc gca atc gtt ggc ccg ctg atc gca 595 Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val Gly Pro Leu Ile Ala 150 155 160 165 ggt gcg ttg att ccg ctg atc ggt ttc ggg tgg ctg tat ttc ctt gat 643 Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp Leu Tyr Phe Leu Asp 170 175 180 gtt gtc tcc atc atc ccc aca ctg tgg gct gta tgg tca ctg cct tcg 691 Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val Trp Ser Leu Pro Ser 185 190 195 atc aag cca tcc ggc aag gtg atg aag gct ggt ttc gcc agt gtg gtg 739 Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly Phe Ala Ser Val Val 200 205 210 gat ggc ctg aag tat ttg gct ggc caa ccc gtg ttg ttg atg gtg atg 787 Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val Leu Leu Met Val Met 215 220 225 gtg ctg gat ctt atc gcc atg att ttc ggc atg cca cgt gcg ctt tac 835 Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met Pro Arg Ala Leu Tyr 230 235 240 245 ccc gag atc gca gaa gtg aac ttc ggt ggg ggt gac gcc ggt gca acg 883 Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly Asp Ala Gly Ala Thr 250 255 260 atg ctg gcg ttc atg tac tca tcc atg gct gtt ggc gca gtt ctt ggc 931 Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val Gly Ala Val Leu Gly 265 270 275 ggc gtg ctg tct ggt tgg gtg gcc cgg att agc cgc cag ggt gtt gca 979 Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser Arg Gln Gly Val Ala 280 285 290 gtt tat tgg tgc atc atc gcc tgg ggc gca gcc gtt gct ttg ggt ggt 1027 Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala Val Ala Leu Gly Gly 295 300 305 gtg gca att gtt gtc agc ccc ggc gcg gtg act gcg tgg gcg tgg atg 1075 Val Ala Ile Val Val Ser Pro Gly Ala Val Thr Ala Trp Ala Trp Met 310 315 320 325 ttc atc atc atg atg gtc att ggt ggc atg gct gac atg ttc agc tcg 1123 Phe Ile Ile Met Met Val Ile Gly Gly Met Ala Asp Met Phe Ser Ser 330 335 340 gca gtt cga aac gct att ttg cag cag tct gct gcg gaa cat gtg cag 1171 Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala Ala Glu His Val Gln 345 350 355 ggc cga atc caa ggt gtg tgg atc atc gtc gtg gtg ggt gga cct cgt 1219 Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val Val Gly Gly Pro Arg 360 365 370 tta gct gac gtc ctt cac ggt tgg gcc gct gag ccc ctc ggc gca ggt 1267 Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu Pro Leu Gly Ala Gly 375 380 385 tgg acg gta tta tgg ggc gga gta gcg gtg gtt gta ctc act gca att 1315 Trp Thr Val Leu Trp Gly Gly Val Ala Val Val Val Leu Thr Ala Ile 390 395 400 405 tgt atg gtg gcg gtg cct aaa ttc tgg aaa tac gag aaa cca aaa att 1363 Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr Glu Lys Pro Lys Ile 410 415 420 acc ggc atc taaatactta tccatgccca tttacagaca 1402 Thr Gly Ile <210> 104 <211> 424 <212> PRT <213> Corynebacterium glutamicum <400> 104 Val Ser Phe Arg Asp Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro 1 5 10 15 Ala Phe Lys Arg Leu Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala 20 25 30 Gln Leu Thr Val Val Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly 35 40 45 Ser Ser Gly Tyr Val Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu 50 55 60 Val Ile Phe Gly Leu Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys 65 70 75 80 Arg Ile Val Leu Ile Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala 85 90 95 Gly Phe Trp Val Leu Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu 100 105 110 Leu Ile Asn Phe Ser Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro 115 120 125 Thr Arg Thr Ala Ile Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala 130 135 140 Ser Ala Thr Ser Leu Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val 145 150 155 160 Gly Pro Leu Ile Ala Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp 165 170 175 Leu Tyr Phe Leu Asp Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val 180 185 190 Trp Ser Leu Pro Ser Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly 195 200 205 Phe Ala Ser Val Val Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val 210 215 220 Leu Leu Met Val Met Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met 225 230 235 240 Pro Arg Ala Leu Tyr Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly 245 250 255 Asp Ala Gly Ala Thr Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val 260 265 270 Gly Ala Val Leu Gly Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser 275 280 285 Arg Gln Gly Val Ala Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala 290 295 300 Val Ala Leu Gly Gly Val Ala Ile Val Val Ser Pro Gly Ala Val Thr 305 310 315 320 Ala Trp Ala Trp Met Phe Ile Ile Met Met Val Ile Gly Gly Met Ala 325 330 335 Asp Met Phe Ser Ser Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala 340 345 350 Ala Glu His Val Gln Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val 355 360 365 Val Gly Gly Pro Arg Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu 370 375 380 Pro Leu Gly Ala Gly Trp Thr Val Leu Trp Gly Gly Val Ala Val Val 385 390 395 400 Val Leu Thr Ala Ile Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr 405 410 415 Glu Lys Pro Lys Ile Thr Gly Ile 420 <210> 105 <211> 1519 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1489) <223> RXA02020 <400> 105 ttggtcaatc aagcgtgaat ccggcttcca tgagccagtt gcccgcctca aagcttgacc 60 cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tct aat 115 Met Ala Lys Ser Asn 1 5 gaa ggg ctg gga acc gga ctt cgg acc cgc cac ctc aca atg atg gga 163 Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His Leu Thr Met Met Gly 10 15 20 ctc ggc tcc gca att ggt gcc gga ctg ttc ctc ggc acc ggc gtt ggt 211 Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu Gly Thr Gly Val Gly 25 30 35 atc cgc gca gcc ggc ccc gca gtg ctc ctg gcg tac atc atc gcc gga 259 Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala Tyr Ile Ile Ala Gly 40 45 50 gcc atc gtt gtg ctt gtt atg caa atg ctc ggc gag atg gct gct gcc 307 Ala Ile Val Val Leu Val Met Gln Met Leu Gly Glu Met Ala Ala Ala 55 60 65 cgt ccc gcc tcc gga tcg ttt tca cgt tac ggc gag gat gct ttc ggc 355 Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly Glu Asp Ala Phe Gly 70 75 80 85 cac tgg gct ggt ttc tcc ctc ggt tgg ttg tac tgg ttc atg ctg att 403 His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr Trp Phe Met Leu Ile 90 95 100 atg gtg atg ggc gcc gaa atg act ggc gct gct gcc atc atg ggt gca 451 Met Val Met Gly Ala Glu Met Thr Gly Ala Ala Ala Ile Met Gly Ala 105 110 115 tgg ttc ggc gtc gaa ccg tgg att cct tcg ctt gtc tgc gtg gtc ttc 499 Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu Val Cys Val Val Phe 120 125 130 ttc gct gtg gtg aac ctc gtc gcg gtt cgc ggt ttc ggt gaa ttc gag 547 Phe Ala Val Val Asn Leu Val Ala Val Arg Gly Phe Gly Glu Phe Glu 135 140 145 tac tgg ttc gca ttc att aag gtc gcg gtg atc atc gct ttc ctc atc 595 Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile Ile Ala Phe Leu Ile 150 155 160 165 att ggt att gct ctt att ttc gga tgg ctt ccc gga tcc acc ttt gtt 643 Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro Gly Ser Thr Phe Val 170 175 180 gga acc tca aac ttc atc ggt gat cac gga ttc atg ccc aat ggt att 691 Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe Met Pro Asn Gly Ile 185 190 195 tct ggt gtt gct gct ggt ttg ctc gcg gtg gct ttt gcc ttt ggt ggc 739 Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala Phe Ala Phe Gly Gly 200 205 210 att gaa att gtc acc att gca gct gca gag tcc gat aag cca cgt gaa 787 Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser Asp Lys Pro Arg Glu 215 220 225 gct att tcc ctg gcg gtg cgt gcc gtg att tgg cgt att tca gtc ttt 835 Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp Arg Ile Ser Val Phe 230 235 240 245 tac ttg ggc tct gtt ttg gtc atc act ttc ctc atg cct tat gag tcg 883 Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu Met Pro Tyr Glu Ser 250 255 260 atc aat ggt gcc gac acc gct gcg gaa tcc ccc ttc acc caa atc ctg 931 Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro Phe Thr Gln Ile Leu 265 270 275 gcg atg gca aac atc cct ggc acg gtt ggt ttc atg gaa gcg atc atc 979 Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe Met Glu Ala Ile Ile 280 285 290 gtt cta gca ctg ctt tcc gct ttc aac gcc caa atc tat gcc act tct 1027 Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln Ile Tyr Ala Thr Ser 295 300 305 cgt ttg gta ttt tcc atg gcg aat cga caa gac gct ccg cga gtt ttc 1075 Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp Ala Pro Arg Val Phe 310 315 320 325 agt aag ctc agc acc agc cac gtc ccc acc aat gcg gtg ctg ttg tcc 1123 Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn Ala Val Leu Leu Ser 330 335 340 atg ttc ttc gcc ttc gtt tca gtt ggt ttg cag tac tgg aat cca gcc 1171 Met Phe Phe Ala Phe Val Ser Val Gly Leu Gln Tyr Trp Asn Pro Ala 345 350 355 ggt ctg ctt gat ttc ctc ctc aac gct gtt ggc ggt tgt ttg att gtg 1219 Gly Leu Leu Asp Phe Leu Leu Asn Ala Val Gly Gly Cys Leu Ile Val 360 365 370 gtg tgg gca atg atc act ttg tca cag ttg aaa ctc cgc aaa gaa ctg 1267 Val Trp Ala Met Ile Thr Leu Ser Gln Leu Lys Leu Arg Lys Glu Leu 375 380 385 caa gca aac gat gaa atc tcc acg gtt cgc atg tgg gcg cac cca tgg 1315 Gln Ala Asn Asp Glu Ile Ser Thr Val Arg Met Trp Ala His Pro Trp 390 395 400 405 tta ggc atc ctc acc ttg gtt ttg ttg gca gga ctc gtt gct ctc atg 1363 Leu Gly Ile Leu Thr Leu Val Leu Leu Ala Gly Leu Val Ala Leu Met 410 415 420 ctc ggc gac gca gcc tcc cgc agc cag gtt tac tca gtg gca att gtg 1411 Leu Gly Asp Ala Ala Ser Arg Ser Gln Val Tyr Ser Val Ala Ile Val 425 430 435 tac gga ttc ttg gtt ctt ttg tcc ttc gtc aca gtt aac agc cca ttg 1459 Tyr Gly Phe Leu Val Leu Leu Ser Phe Val Thr Val Asn Ser Pro Leu 440 445 450 cgc gga ggt cgc acc cct tcc gac ttg aac tgataggccg atagaaatta 1509 Arg Gly Gly Arg Thr Pro Ser Asp Leu Asn 455 460 ttctggacgt 1519 <210> 106 <211> 463 <212> PRT <213> Corynebacterium glutamicum <400> 106 Met Ala Lys Ser Asn Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His 1 5 10 15 Leu Thr Met Met Gly Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu 20 25 30 Gly Thr Gly Val Gly Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala 35 40 45 Tyr Ile Ile Ala Gly Ala Ile Val Val Leu Val Met Gln Met Leu Gly 50 55 60 Glu Met Ala Ala Ala Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly 65 70 75 80 Glu Asp Ala Phe Gly His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr 85 90 95 Trp Phe Met Leu Ile Met Val Met Gly Ala Glu Met Thr Gly Ala Ala 100 105 110 Ala Ile Met Gly Ala Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu 115 120 125 Val Cys Val Val Phe Phe Ala Val Val Asn Leu Val Ala Val Arg Gly 130 135 140 Phe Gly Glu Phe Glu Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile 145 150 155 160 Ile Ala Phe Leu Ile Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro 165 170 175 Gly Ser Thr Phe Val Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe 180 185 190 Met Pro Asn Gly Ile Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala 195 200 205 Phe Ala Phe Gly Gly Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser 210 215 220 Asp Lys Pro Arg Glu Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp 225 230 235 240 Arg Ile Ser Val Phe Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu 245 250 255 Met Pro Tyr Glu Ser Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro 260 265 270 Phe Thr Gln Ile Leu Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe 275 280 285 Met Glu Ala Ile Ile Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln 290 295 300 Ile Tyr Ala Thr Ser Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp 305 310 315 320 Ala Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn 325 330 335 Ala Val Leu Leu Ser Met Phe Phe Ala Phe Val Ser Val Gly Leu Gln 340 345 350 Tyr Trp Asn Pro Ala Gly Leu Leu Asp Phe Leu Leu Asn Ala Val Gly 355 360 365 Gly Cys Leu Ile Val Val Trp Ala Met Ile Thr Leu Ser Gln Leu Lys 370 375 380 Leu Arg Lys Glu Leu Gln Ala Asn Asp Glu Ile Ser Thr Val Arg Met 385 390 395 400 Trp Ala His Pro Trp Leu Gly Ile Leu Thr Leu Val Leu Leu Ala Gly 405 410 415 Leu Val Ala Leu Met Leu Gly Asp Ala Ala Ser Arg Ser Gln Val Tyr 420 425 430 Ser Val Ala Ile Val Tyr Gly Phe Leu Val Leu Leu Ser Phe Val Thr 435 440 445 Val Asn Ser Pro Leu Arg Gly Gly Arg Thr Pro Ser Asp Leu Asn 450 455 460 <210> 107 <211> 1444 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1414) <223> RXA02029 <400> 107 cgcacgtaca ctacttttag cagttaaccc gccgaacttt cttgattaag tattcattga 60 gcgttcttgg cataaatccc actggaggtg catcaaacgt atg gca gag gca cgt 115 Met Ala Glu Ala Arg 1 5 ttg cgc cat ctt gaa ccc att gat gtg gaa gag tgg cct ggg gtg gcg 163 Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu Trp Pro Gly Val Ala 10 15 20 tca gtg ccc aac cta gcg ttt gct ggt gca cgc gca cgg caa gca gaa 211 Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg Ala Arg Gln Ala Glu 25 30 35 tat cga ttt gcc aag gcc tgc agc aac gca ggt tta gtt ctg cta gga 259 Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly Leu Val Leu Leu Gly 40 45 50 aat gac ccg gat ctc att att gat cat gag gaa tta ttc tca cgt ttg 307 Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu Leu Phe Ser Arg Leu 55 60 65 gcc gca tcg ggc tgg ctg ggg ctc gct gag agc tac atg gca ggc gag 355 Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser Tyr Met Ala Gly Glu 70 75 80 85 tgg cgc agc gag agg ctt gcc gac gtc ttg acc gct ttg ttg gga act 403 Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr Ala Leu Leu Gly Thr 90 95 100 ggg ttt aaa ccc cgc ggc aaa cta tct gga tcg ttc acc ctg cca ggg 451 Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser Phe Thr Leu Pro Gly 105 110 115 caa gct gtg gat gcc gga ggc gca cta ccc aat gaa ctc att cgt tta 499 Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn Glu Leu Ile Arg Leu 120 125 130 agt tca ggt gat ggc atg agc gca ttt ggt gga gtt ttt gcc tcc ggt 547 Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly Val Phe Ala Ser Gly 135 140 145 gtt cca acc act tta cgt acc gca gtg aaa agc cat gtg ccg gga gct 595 Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser His Val Pro Gly Ala 150 155 160 165 ggt cgc aat agg gag ccc gca tct cac ttt gtg gat atc acc aag atc 643 Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val Asp Ile Thr Lys Ile 170 175 180 tcg gag cct gtg gcc gtg gag cgt gaa gac ctc ggc gag gct cag cgc 691 Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu Gly Glu Ala Gln Arg 185 190 195 cga gca gcg tcc ttt ttg ctt gac ggc gcc aaa gtt aaa gcc gga agc 739 Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys Val Lys Ala Gly Ser 200 205 210 cat gtg ttg gag ttt ccc agc agt ggt gga gct tta gct att ttg gct 787 His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala Leu Ala Ile Leu Ala 215 220 225 gct cga cgc cag gga act gtt gac gct tta acg gct gat ccc gcg caa 835 Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr Ala Asp Pro Ala Gln 230 235 240 245 gtt tca agc ctg gag gag acg ttt gtg ctc gcc ggt gtg gag gag gat 883 Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala Gly Val Glu Glu Asp 250 255 260 att cac atc gag gtc att ccc cag gcg att ccc tcg cca cgc gaa tgg 931 Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro Ser Pro Arg Glu Trp 265 270 275 ggt ggc gcc tac gat tcg ata gtc gcc atg gag aag cta gaa gtg gtg 979 Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu Lys Leu Glu Val Val 280 285 290 ggc aag cac ggt tcc aag cgg ttt att aaa gct atc gac aga atg ctc 1027 Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala Ile Asp Arg Met Leu 295 300 305 acc acc ggc ggc aac gta gcc atg caa tcc ttg gta gct act gac caa 1075 Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu Val Ala Thr Asp Gln 310 315 320 325 tgg agt cct gtg tgt tct gaa gcg att tct ttg ctc aag gcc tat att 1123 Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu Leu Lys Ala Tyr Ile 330 335 340 tgg cct gcg ctg cat tac cca act gtt gat gaa gtt cat cag ctt gtt 1171 Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu Val His Gln Leu Val 345 350 355 gat agg gat tct tct ctg cgc gtg gtg aag gaa aca cac ttt gcg ggc 1219 Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu Thr His Phe Ala Gly 360 365 370 cat tac cta aaa agc gtg cag ttg caa cgt gaa gtg ttt gaa ggc cag 1267 His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu Val Phe Glu Gly Gln 375 380 385 ata cgc gaa gcg gcg gca gat ggc ttt gat gcc gtc tac cgc cgc atg 1315 Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala Val Tyr Arg Arg Met 390 395 400 405 tgg gtg tat cac tac gcg ctt att gaa gcc ctg tta cgc ctg gga tgt 1363 Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu Leu Arg Leu Gly Cys 410 415 420 ctc aat gca gtg caa ttt gcg ttg acg aca aga aac aga agg ggg cgt 1411 Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg Asn Arg Arg Gly Arg 425 430 435 cga taagcaaaaa tcttttagac ctctcggagg 1444 Arg <210> 108 <211> 438 <212> PRT <213> Corynebacterium glutamicum <400> 108 Met Ala Glu Ala Arg Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu 1 5 10 15 Trp Pro Gly Val Ala Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg 20 25 30 Ala Arg Gln Ala Glu Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly 35 40 45 Leu Val Leu Leu Gly Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu 50 55 60 Leu Phe Ser Arg Leu Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser 65 70 75 80 Tyr Met Ala Gly Glu Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr 85 90 95 Ala Leu Leu Gly Thr Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser 100 105 110 Phe Thr Leu Pro Gly Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn 115 120 125 Glu Leu Ile Arg Leu Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly 130 135 140 Val Phe Ala Ser Gly Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser 145 150 155 160 His Val Pro Gly Ala Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val 165 170 175 Asp Ile Thr Lys Ile Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu 180 185 190 Gly Glu Ala Gln Arg Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys 195 200 205 Val Lys Ala Gly Ser His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala 210 215 220 Leu Ala Ile Leu Ala Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr 225 230 235 240 Ala Asp Pro Ala Gln Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala 245 250 255 Gly Val Glu Glu Asp Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro 260 265 270 Ser Pro Arg Glu Trp Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu 275 280 285 Lys Leu Glu Val Val Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala 290 295 300 Ile Asp Arg Met Leu Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu 305 310 315 320 Val Ala Thr Asp Gln Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu 325 330 335 Leu Lys Ala Tyr Ile Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu 340 345 350 Val His Gln Leu Val Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu 355 360 365 Thr His Phe Ala Gly His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu 370 375 380 Val Phe Glu Gly Gln Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala 385 390 395 400 Val Tyr Arg Arg Met Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu 405 410 415 Leu Arg Leu Gly Cys Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg 420 425 430 Asn Arg Arg Gly Arg Arg 435 <210> 109 <211> 1096 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1066) <223> RXA02034 <400> 109 tcgtggtgat gtcaccagag atcaccggca ttgatcccaa cgtggtgtcc ggggcgttgg 60 aattgtcgtt gattggtcgg aaagaatccg gggtagcgca gtg agt aaa aca atc 115 Val Ser Lys Thr Ile 1 5 gct tgg act gtg ctg cgg tac acc ctg act ttt gtg atc gcc agc atc 163 Ala Trp Thr Val Leu Arg Tyr Thr Leu Thr Phe Val Ile Ala Ser Ile 10 15 20 atc att ttt gtg ctg att cga gtc atc ccc ggt gac ccc gcc gct gtt 211 Ile Ile Phe Val Leu Ile Arg Val Ile Pro Gly Asp Pro Ala Ala Val 25 30 35 gcc ctg gga att acc gcg aca cca gaa gca atc gct gcg ttg caa tca 259 Ala Leu Gly Ile Thr Ala Thr Pro Glu Ala Ile Ala Ala Leu Gln Ser 40 45 50 caa tta ggt act gat caa ccg ctt ttc caa cag tac ttt tcc tgg ata 307 Gln Leu Gly Thr Asp Gln Pro Leu Phe Gln Gln Tyr Phe Ser Trp Ile 55 60 65 ggt gga atg ctc act ggc gat ttc ggc acc tcg ctg agc tct ggc caa 355 Gly Gly Met Leu Thr Gly Asp Phe Gly Thr Ser Leu Ser Ser Gly Gln 70 75 80 85 gac ctt tcc ccc atc att ttt gac cgc tta caa gtg agc ctc att ttg 403 Asp Leu Ser Pro Ile Ile Phe Asp Arg Leu Gln Val Ser Leu Ile Leu 90 95 100 gtg gga tgc tcc att gtg ttg tcg ttg ctc att gcc att cca ctt ggt 451 Val Gly Cys Ser Ile Val Leu Ser Leu Leu Ile Ala Ile Pro Leu Gly 105 110 115 gtg ctt tcg gcc cgg cgc ggt ggc gtg atc att tcc ggc atc agc cag 499 Val Leu Ser Ala Arg Arg Gly Gly Val Ile Ile Ser Gly Ile Ser Gln 120 125 130 att ggc att gcg atc cct agt ttc ctc gcc ggt att ttg ttg gtc gct 547 Ile Gly Ile Ala Ile Pro Ser Phe Leu Ala Gly Ile Leu Leu Val Ala 135 140 145 gtc ttc gcc gtt ggt ttg ggg tgg ctg ccc gcc aat ggc tgg att ccg 595 Val Phe Ala Val Gly Leu Gly Trp Leu Pro Ala Asn Gly Trp Ile Pro 150 155 160 165 ccg tcg gaa aac ttt gga ggt ttc tta gcc agg ctg atc ctc ccg gtt 643 Pro Ser Glu Asn Phe Gly Gly Phe Leu Ala Arg Leu Ile Leu Pro Val 170 175 180 ctg gct ctt act gct gtt caa gca gca att ttg acc cgc tat gtc cgc 691 Leu Ala Leu Thr Ala Val Gln Ala Ala Ile Leu Thr Arg Tyr Val Arg 185 190 195 tct gca gta atg gat gta atg ggg caa gat ttc atg cgc acc gcg agg 739 Ser Ala Val Met Asp Val Met Gly Gln Asp Phe Met Arg Thr Ala Arg 200 205 210 tcg aaa ggt atg agc ttc aac cgc gcg ttg atc atc cac ggt ctt cgg 787 Ser Lys Gly Met Ser Phe Asn Arg Ala Leu Ile Ile His Gly Leu Arg 215 220 225 aat gct gct ctt cct gtc ctt acc gtc act ggt ttg cag cta aca acc 835 Asn Ala Ala Leu Pro Val Leu Thr Val Thr Gly Leu Gln Leu Thr Thr 230 235 240 245 ttg gtt atc ggc gcc gtg gtg att gaa caa gtc ttt gtc atc ccc gga 883 Leu Val Ile Gly Ala Val Val Ile Glu Gln Val Phe Val Ile Pro Gly 250 255 260 atc ggt tcg atg ctg ctg gag tcc gtg tcc aac cgt gat ctc atc gct 931 Ile Gly Ser Met Leu Leu Glu Ser Val Ser Asn Arg Asp Leu Ile Ala 265 270 275 gtg caa tct att gtc atg ctg ctg gtg gcg ttc acg ttg ctg gtt aat 979 Val Gln Ser Ile Val Met Leu Leu Val Ala Phe Thr Leu Leu Val Asn 280 285 290 ttg gtg gtt gat ctg ctg tat cag gtg gtt gat cca aga gtc ggt gct 1027 Leu Val Val Asp Leu Leu Tyr Gln Val Val Asp Pro Arg Val Gly Ala 295 300 305 gtt ggg gtt gct agc act aag gtt cca ggg agc gtg gct taagtgacaa 1076 Val Gly Val Ala Ser Thr Lys Val Pro Gly Ser Val Ala 310 315 320 cgatcaaaaa catgcccctt 1096 <210> 110 <211> 322 <212> PRT <213> Corynebacterium glutamicum <400> 110 Val Ser Lys Thr Ile Ala Trp Thr Val Leu Arg Tyr Thr Leu Thr Phe 1 5 10 15 Val Ile Ala Ser Ile Ile Ile Phe Val Leu Ile Arg Val Ile Pro Gly 20 25 30 Asp Pro Ala Ala Val Ala Leu Gly Ile Thr Ala Thr Pro Glu Ala Ile 35 40 45 Ala Ala Leu Gln Ser Gln Leu Gly Thr Asp Gln Pro Leu Phe Gln Gln 50 55 60 Tyr Phe Ser Trp Ile Gly Gly Met Leu Thr Gly Asp Phe Gly Thr Ser 65 70 75 80 Leu Ser Ser Gly Gln Asp Leu Ser Pro Ile Ile Phe Asp Arg Leu Gln 85 90 95 Val Ser Leu Ile Leu Val Gly Cys Ser Ile Val Leu Ser Leu Leu Ile 100 105 110 Ala Ile Pro Leu Gly Val Leu Ser Ala Arg Arg Gly Gly Val Ile Ile 115 120 125 Ser Gly Ile Ser Gln Ile Gly Ile Ala Ile Pro Ser Phe Leu Ala Gly 130 135 140 Ile Leu Leu Val Ala Val Phe Ala Val Gly Leu Gly Trp Leu Pro Ala 145 150 155 160 Asn Gly Trp Ile Pro Pro Ser Glu Asn Phe Gly Gly Phe Leu Ala Arg 165 170 175 Leu Ile Leu Pro Val Leu Ala Leu Thr Ala Val Gln Ala Ala Ile Leu 180 185 190 Thr Arg Tyr Val Arg Ser Ala Val Met Asp Val Met Gly Gln Asp Phe 195 200 205 Met Arg Thr Ala Arg Ser Lys Gly Met Ser Phe Asn Arg Ala Leu Ile 210 215 220 Ile His Gly Leu Arg Asn Ala Ala Leu Pro Val Leu Thr Val Thr Gly 225 230 235 240 Leu Gln Leu Thr Thr Leu Val Ile Gly Ala Val Val Ile Glu Gln Val 245 250 255 Phe Val Ile Pro Gly Ile Gly Ser Met Leu Leu Glu Ser Val Ser Asn 260 265 270 Arg Asp Leu Ile Ala Val Gln Ser Ile Val Met Leu Leu Val Ala Phe 275 280 285 Thr Leu Leu Val Asn Leu Val Val Asp Leu Leu Tyr Gln Val Val Asp 290 295 300 Pro Arg Val Gly Ala Val Gly Val Ala Ser Thr Lys Val Pro Gly Ser 305 310 315 320 Val Ala <210> 111 <211> 1639 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1609) <223> RXA02035 <400> 111 ggattttcca ttggcggagg ttcatgcggc gggtatccat tgccttccat tttagttttc 60 catttagttt cccggatcac accgactaat ctcagaagcc atg aag atc acg cgc 115 Met Lys Ile Thr Arg 1 5 gga ctc ctg cca tca ttg ctg ttg gca agc aca atc gtg gtg tcg tca 163 Gly Leu Leu Pro Ser Leu Leu Leu Ala Ser Thr Ile Val Val Ser Ser 10 15 20 tgc tct gct gga tcg act gcg tat cag cag ccc cct gct gtt gat caa 211 Cys Ser Ala Gly Ser Thr Ala Tyr Gln Gln Pro Pro Ala Val Asp Gln 25 30 35 tca tcc att gtc att gct acc acg gct gct gcg gcg tca ctt gat ttc 259 Ser Ser Ile Val Ile Ala Thr Thr Ala Ala Ala Ala Ser Leu Asp Phe 40 45 50 acc aat gct gcg ggc gct gct att ccg cag gcg atg atg tcc aat att 307 Thr Asn Ala Ala Gly Ala Ala Ile Pro Gln Ala Met Met Ser Asn Ile 55 60 65 tac gag ggg ctt gtg cgc atc gat gcg gag ggt gag att cag ccg ctg 355 Tyr Glu Gly Leu Val Arg Ile Asp Ala Glu Gly Glu Ile Gln Pro Leu 70 75 80 85 ctt gcc acg tcg tgg gat att tca gac gat cgc acc gag tac att ttc 403 Leu Ala Thr Ser Trp Asp Ile Ser Asp Asp Arg Thr Glu Tyr Ile Phe 90 95 100 cat ttg cgg gag ggt gtg ctg ttt tcc aac ggc gat ccc ttc aat gct 451 His Leu Arg Glu Gly Val Leu Phe Ser Asn Gly Asp Pro Phe Asn Ala 105 110 115 gat tct gcg aag ttt tcc att gat cgg gta aaa act gac tgg acc aat 499 Asp Ser Ala Lys Phe Ser Ile Asp Arg Val Lys Thr Asp Trp Thr Asn 120 125 130 ggt ttg aaa agt ggc atg gat gtg gtg gag tcc acc gag gtg att gac 547 Gly Leu Lys Ser Gly Met Asp Val Val Glu Ser Thr Glu Val Ile Asp 135 140 145 gat cac acg ctg aaa gtt tcg ctg gtc agg ccg tcc aac caa tgg ttg 595 Asp His Thr Leu Lys Val Ser Leu Val Arg Pro Ser Asn Gln Trp Leu 150 155 160 165 tgg agc atg ggt acc gcg atc ggt gcc atg atg acg gag ggg ggc gtc 643 Trp Ser Met Gly Thr Ala Ile Gly Ala Met Met Thr Glu Gly Gly Val 170 175 180 gat aag ctg gca act gat ccc gtt ggc acc ggc ccg tac acg gtg acg 691 Asp Lys Leu Ala Thr Asp Pro Val Gly Thr Gly Pro Tyr Thr Val Thr 185 190 195 cac tgg gcg ccg ggc cgc gca att ggg ttc ggc gcg cgg gcc gat tat 739 His Trp Ala Pro Gly Arg Ala Ile Gly Phe Gly Ala Arg Ala Asp Tyr 200 205 210 tgg ggg cag aag ccg ctt aac gac gcc gca acc atc cgc tac ttc agc 787 Trp Gly Gln Lys Pro Leu Asn Asp Ala Ala Thr Ile Arg Tyr Phe Ser 215 220 225 gat gcg acg gcc tcg acc aat gcg ctg caa agc ggt gac gtg gac gtg 835 Asp Ala Thr Ala Ser Thr Asn Ala Leu Gln Ser Gly Asp Val Asp Val 230 235 240 245 att tgg gcg atg caa gcg ccc gaa cag ctg gct acg ctg cag gaa tac 883 Ile Trp Ala Met Gln Ala Pro Glu Gln Leu Ala Thr Leu Gln Glu Tyr 250 255 260 acc gtg gaa gtg ggc aca acc aat ggt gag atg ttg ctg tcg atg aat 931 Thr Val Glu Val Gly Thr Thr Asn Gly Glu Met Leu Leu Ser Met Asn 265 270 275 aat cag cgt gca cct ttt gat gat gtg cgt gtg cgc cag gcg gtg atg 979 Asn Gln Arg Ala Pro Phe Asp Asp Val Arg Val Arg Gln Ala Val Met 280 285 290 ttt gcg att gat cgc caa gcc gtc att gat acc gcg ttg gaa ggt tac 1027 Phe Ala Ile Asp Arg Gln Ala Val Ile Asp Thr Ala Leu Glu Gly Tyr 295 300 305 ggc acc gac act ggt ggc gtg cct gtt ccg ccg act gat ccg tgg tac 1075 Gly Thr Asp Thr Gly Gly Val Pro Val Pro Pro Thr Asp Pro Trp Tyr 310 315 320 325 gag aaa tcc acg atg tac ccc tac gat ccg gac cgc gca cgg gca ttg 1123 Glu Lys Ser Thr Met Tyr Pro Tyr Asp Pro Asp Arg Ala Arg Ala Leu 330 335 340 tta gag gag gcc ggc gcc gag gga acg cgg atc acc atg tcc att cct 1171 Leu Glu Glu Ala Gly Ala Glu Gly Thr Arg Ile Thr Met Ser Ile Pro 345 350 355 tcg ttg ccg tac gct cag gca gcc tct gaa atc ctg tac tcg caa ctg 1219 Ser Leu Pro Tyr Ala Gln Ala Ala Ser Glu Ile Leu Tyr Ser Gln Leu 360 365 370 cga gat gtt ggt ttt gat cct gtg att gaa tca acc gag ttc cca gcc 1267 Arg Asp Val Gly Phe Asp Pro Val Ile Glu Ser Thr Glu Phe Pro Ala 375 380 385 gtc tgg ttg gca cag gtc atg ggg caa aaa gac tac gac atg tca cta 1315 Val Trp Leu Ala Gln Val Met Gly Gln Lys Asp Tyr Asp Met Ser Leu 390 395 400 405 atc gcg cat gtg gaa ccc cgc gac atc ccc acg ctg ttt agc ccc aac 1363 Ile Ala His Val Glu Pro Arg Asp Ile Pro Thr Leu Phe Ser Pro Asn 410 415 420 tac tat ttg ggc ttt gac gac acc gaa acc caa gcc ctc ctc gca gag 1411 Tyr Tyr Leu Gly Phe Asp Asp Thr Glu Thr Gln Ala Leu Leu Ala Glu 425 430 435 gca gac agt tca gca aac gaa gtg gaa ttg atg caa caa gct gtc gat 1459 Ala Asp Ser Ser Ala Asn Glu Val Glu Leu Met Gln Gln Ala Val Asp 440 445 450 cga atc atg gaa caa gcc gtc gcc gac aac ctc atg aac gtg gcc aac 1507 Arg Ile Met Glu Gln Ala Val Ala Asp Asn Leu Met Asn Val Ala Asn 455 460 465 atc gtg gtg atg tca cca gag atc acc ggc att gat ccc aac gtg gtg 1555 Ile Val Val Met Ser Pro Glu Ile Thr Gly Ile Asp Pro Asn Val Val 470 475 480 485 tcc ggg gcg ttg gaa ttg tcg ttg att ggt cgg aaa gaa tcc ggg gta 1603 Ser Gly Ala Leu Glu Leu Ser Leu Ile Gly Arg Lys Glu Ser Gly Val 490 495 500 gcg cag tgagtaaaac aatcgcttgg actgtgctgc 1639 Ala Gln <210> 112 <211> 503 <212> PRT <213> Corynebacterium glutamicum <400> 112 Met Lys Ile Thr Arg Gly Leu Leu Pro Ser Leu Leu Leu Ala Ser Thr 1 5 10 15 Ile Val Val Ser Ser Cys Ser Ala Gly Ser Thr Ala Tyr Gln Gln Pro 20 25 30 Pro Ala Val Asp Gln Ser Ser Ile Val Ile Ala Thr Thr Ala Ala Ala 35 40 45 Ala Ser Leu Asp Phe Thr Asn Ala Ala Gly Ala Ala Ile Pro Gln Ala 50 55 60 Met Met Ser Asn Ile Tyr Glu Gly Leu Val Arg Ile Asp Ala Glu Gly 65 70 75 80 Glu Ile Gln Pro Leu Leu Ala Thr Ser Trp Asp Ile Ser Asp Asp Arg 85 90 95 Thr Glu Tyr Ile Phe His Leu Arg Glu Gly Val Leu Phe Ser Asn Gly 100 105 110 Asp Pro Phe Asn Ala Asp Ser Ala Lys Phe Ser Ile Asp Arg Val Lys 115 120 125 Thr Asp Trp Thr Asn Gly Leu Lys Ser Gly Met Asp Val Val Glu Ser 130 135 140 Thr Glu Val Ile Asp Asp His Thr Leu Lys Val Ser Leu Val Arg Pro 145 150 155 160 Ser Asn Gln Trp Leu Trp Ser Met Gly Thr Ala Ile Gly Ala Met Met 165 170 175 Thr Glu Gly Gly Val Asp Lys Leu Ala Thr Asp Pro Val Gly Thr Gly 180 185 190 Pro Tyr Thr Val Thr His Trp Ala Pro Gly Arg Ala Ile Gly Phe Gly 195 200 205 Ala Arg Ala Asp Tyr Trp Gly Gln Lys Pro Leu Asn Asp Ala Ala Thr 210 215 220 Ile Arg Tyr Phe Ser Asp Ala Thr Ala Ser Thr Asn Ala Leu Gln Ser 225 230 235 240 Gly Asp Val Asp Val Ile Trp Ala Met Gln Ala Pro Glu Gln Leu Ala 245 250 255 Thr Leu Gln Glu Tyr Thr Val Glu Val Gly Thr Thr Asn Gly Glu Met 260 265 270 Leu Leu Ser Met Asn Asn Gln Arg Ala Pro Phe Asp Asp Val Arg Val 275 280 285 Arg Gln Ala Val Met Phe Ala Ile Asp Arg Gln Ala Val Ile Asp Thr 290 295 300 Ala Leu Glu Gly Tyr Gly Thr Asp Thr Gly Gly Val Pro Val Pro Pro 305 310 315 320 Thr Asp Pro Trp Tyr Glu Lys Ser Thr Met Tyr Pro Tyr Asp Pro Asp 325 330 335 Arg Ala Arg Ala Leu Leu Glu Glu Ala Gly Ala Glu Gly Thr Arg Ile 340 345 350 Thr Met Ser Ile Pro Ser Leu Pro Tyr Ala Gln Ala Ala Ser Glu Ile 355 360 365 Leu Tyr Ser Gln Leu Arg Asp Val Gly Phe Asp Pro Val Ile Glu Ser 370 375 380 Thr Glu Phe Pro Ala Val Trp Leu Ala Gln Val Met Gly Gln Lys Asp 385 390 395 400 Tyr Asp Met Ser Leu Ile Ala His Val Glu Pro Arg Asp Ile Pro Thr 405 410 415 Leu Phe Ser Pro Asn Tyr Tyr Leu Gly Phe Asp Asp Thr Glu Thr Gln 420 425 430 Ala Leu Leu Ala Glu Ala Asp Ser Ser Ala Asn Glu Val Glu Leu Met 435 440 445 Gln Gln Ala Val Asp Arg Ile Met Glu Gln Ala Val Ala Asp Asn Leu 450 455 460 Met Asn Val Ala Asn Ile Val Val Met Ser Pro Glu Ile Thr Gly Ile 465 470 475 480 Asp Pro Asn Val Val Ser Gly Ala Leu Glu Leu Ser Leu Ile Gly Arg 485 490 495 Lys Glu Ser Gly Val Ala Gln 500 <210> 113 <211> 1357 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1327) <223> RXA02062 <400> 113 tcacaccctt aaccataaag gcaaaataac tatcccgcat gaaagctggg taacaaattg 60 tctaaacatc gttttggggt ccgaatgata gcccctttta atg ccc cca ttt cgg 115 Met Pro Pro Phe Arg 1 5 tat cgc tgc gca act gtt ttt aga tgg cta atc ttt gaa att atg aga 163 Tyr Arg Cys Ala Thr Val Phe Arg Trp Leu Ile Phe Glu Ile Met Arg 10 15 20 gtc gga atg atg aca aga gag tat cca cca gag gtt tac ggc ggc gct 211 Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly Gly Ala 25 30 35 ggc gtg cac gtc acc gaa ttg acc cga ttc atg cgt gag atc gct gaa 259 Gly Val His Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile Ala Glu 40 45 50 gtt gat gtt cac tgc atg ggt gca cct cgc gat atg gag gga gtt ttc 307 Val Asp Val His Cys Met Gly Ala Pro Arg Asp Met Glu Gly Val Phe 55 60 65 gtc cac ggc gtc gat cct gcc ttg gaa agc gcg aac cct gcg att aag 355 Val His Gly Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala Ile Lys 70 75 80 85 aca ctg tcc acc ggt tta cgc atg gca gaa gct gca aac aac gtg gat 403 Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn Val Asp 90 95 100 gtc gtg cac tca cac act tgg tat gca ggt ctt ggc ggc cac ctt gca 451 Val Val His Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His Leu Ala 105 110 115 gct cgt ctc cac ggc att cct cac gtg gct acc gcg cac tct ttg gag 499 Ala Arg Leu His Gly Ile Pro His Val Ala Thr Ala His Ser Leu Glu 120 125 130 cca gat cgc cca tgg aag cgt gag cag ctt ggc ggt gga tac gac gtg 547 Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr Asp Val 135 140 145 tcc tcc tgg tct gaa aaa aat gcc atg gaa tac gct gac gcg gtc atc 595 Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala Val Ile 150 155 160 165 gct gtg tcg gct cgc atg aaa gat tcc atc ctc gct gcg tac cct cgc 643 Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr Pro Arg 170 175 180 atc gag ccg gac aac gtg cgt gtt gtc ctc aac ggc atc gac act gag 691 Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp Thr Glu 185 190 195 ttg tgg cag cct cgc ccg act ttc gat gac gcg gaa gat tcc gta ctc 739 Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser Val Leu 200 205 210 cgc tcc cta ggc gtt gac cca cag cgg ccc atc gtc gca ttt gtc ggc 787 Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe Val Gly 215 220 225 cgc atc acc cgc caa aaa ggc gtc gag cac ctc atc aag gca gca gcg 835 Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala Ala Ala 230 235 240 245 ctt ttc gac gag tcc gtg cag ctt gtg ctc tgt gcc ggc gcg cca gac 883 Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp 250 255 260 acc ccc gaa atc gca gct cgc acc acc gcc ctg gtg gaa gaa ctc cag 931 Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu Leu Gln 265 270 275 gca aag cgc gaa ggc att ttc tgg gtt cag gac atg ctg ggc aag gac 979 Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly Lys Asp 280 285 290 aaa atc caa gag att ctc acc gct gct gac acc ttc gtg tgc cca tcc 1027 Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys Pro Ser 295 300 305 att tac gag cca ctg ggc atc gtg aac ttg gaa gca atg gcc tgc aac 1075 Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala Cys Asn 310 315 320 325 acc gca gtt gtc gca tcc gac gtt gga ggc atc cct gag gtt gtt gtc 1123 Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val Val Val 330 335 340 gac ggc acc acc ggc gcc ctc gtt cac tac gac gaa aat gat gtc gaa 1171 Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp Val Glu 345 350 355 acc ttc gag cgc gat atc gcc gaa gcg gtg aat aaa atg gtc gct gat 1219 Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val Ala Asp 360 365 370 cga gag acc gca gcc aaa ttt ggt ctc gca ggg cgc gaa cgt gct atc 1267 Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg Ala Ile 375 380 385 aat gat ttc tcc tgg gca acg att gct cag cag acc att gat gtg tac 1315 Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp Val Tyr 390 395 400 405 aaa tcc ttg atg taaaaccgaa agccggggaa cctctccccg 1357 Lys Ser Leu Met <210> 114 <211> 409 <212> PRT <213> Corynebacterium glutamicum <400> 114 Met Pro Pro Phe Arg Tyr Arg Cys Ala Thr Val Phe Arg Trp Leu Ile 1 5 10 15 Phe Glu Ile Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu 20 25 30 Val Tyr Gly Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met 35 40 45 Arg Glu Ile Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp 50 55 60 Met Glu Gly Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala 65 70 75 80 Asn Pro Ala Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala 85 90 95 Ala Asn Asn Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu 100 105 110 Gly Gly His Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr 115 120 125 Ala His Ser Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly 130 135 140 Gly Gly Tyr Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr 145 150 155 160 Ala Asp Ala Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu 165 170 175 Ala Ala Tyr Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn 180 185 190 Gly Ile Asp Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala 195 200 205 Glu Asp Ser Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile 210 215 220 Val Ala Phe Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu 225 230 235 240 Ile Lys Ala Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys 245 250 255 Ala Gly Ala Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu 260 265 270 Val Glu Glu Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp 275 280 285 Met Leu Gly Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr 290 295 300 Phe Val Cys Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu 305 310 315 320 Ala Met Ala Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile 325 330 335 Pro Glu Val Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp 340 345 350 Glu Asn Asp Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn 355 360 365 Lys Met Val Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly 370 375 380 Arg Glu Arg Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln 385 390 395 400 Thr Ile Asp Val Tyr Lys Ser Leu Met 405 <210> 115 <211> 1753 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1723) <223> RXA02074 <400> 115 cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60 tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115 Met Arg Ser Leu Leu 1 5 cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163 Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val 10 15 20 cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211 Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile 25 30 35 gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259 Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala 40 45 50 ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307 Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro 55 60 65 caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355 Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala 70 75 80 85 gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403 Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu 90 95 100 atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451 Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val 105 110 115 atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499 Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val 120 125 130 att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547 Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu 135 140 145 tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595 Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg 150 155 160 165 atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643 Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu 170 175 180 gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691 Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met 185 190 195 ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739 Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu 200 205 210 aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787 Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met 215 220 225 att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835 Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala 230 235 240 245 gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883 Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly 250 255 260 caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931 Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile 265 270 275 aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979 Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser 280 285 290 ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027 Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro 295 300 305 act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075 Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu 310 315 320 325 aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123 Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser 330 335 340 att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171 Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly 345 350 355 aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219 Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly 360 365 370 gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267 Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala 375 380 385 tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315 Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile 390 395 400 405 aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363 Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile 410 415 420 cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411 His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly 425 430 435 gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459 Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile 440 445 450 gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507 Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala 455 460 465 acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555 Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala 470 475 480 485 aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603 Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu 490 495 500 gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651 Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr 505 510 515 atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699 Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg 520 525 530 acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttggctaaga 1753 Thr Ala Val Met Glu Glu Glu Gln 535 540 <210> 116 <211> 541 <212> PRT <213> Corynebacterium glutamicum <400> 116 Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr 1 5 10 15 Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly 20 25 30 Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu 35 40 45 Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala 50 55 60 Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp 65 70 75 80 Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser 85 90 95 Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala 100 105 110 Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu 115 120 125 Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro 130 135 140 Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile 145 150 155 160 Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg 165 170 175 Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu 180 185 190 Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile 195 200 205 Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr 210 215 220 Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala 225 230 235 240 Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly 245 250 255 Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu 260 265 270 Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met 275 280 285 Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr 290 295 300 Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His 325 330 335 Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly 340 345 350 Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu 355 360 365 Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met 370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val 405 410 415 Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala 420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala 435 440 445 Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile 450 455 460 Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln 465 470 475 480 Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr 485 490 495 His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu 500 505 510 Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His 515 520 525 Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln 530 535 540 <210> 117 <211> 3871 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3841) <223> RXA02095 <400> 117 ctctcttggt cctctcccca cccattttta agtactcaag acccttccaa cagaaaggat 60 tactccccca acaggctcaa aaatactgaa aggctcacgc atg aaa act gag caa 115 Met Lys Thr Glu Gln 1 5 tcc caa aaa gca caa tta gcc cct aag aaa gca cct gaa aag cca caa 163 Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala Pro Glu Lys Pro Gln 10 15 20 cgc atc cgc caa ctt att tcc gtg gcg tgg cag cga cct tgg ctc acc 211 Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln Arg Pro Trp Leu Thr 25 30 35 tca ttc acc gta atc agc gct tta gct gca acg ttg ttt gaa ctt aca 259 Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr Leu Phe Glu Leu Thr 40 45 50 ctt cct ctt ttg acc ggt ggc gcc atc gat atc gcg ctc gga aat acc 307 Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile Ala Leu Gly Asn Thr 55 60 65 gga gat act tta acc act gac ctg ctg gac cgg ttc act ccg agt gga 355 Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly 70 75 80 85 tta agc gtg ttg acc agc gtc att gcc ctt atc gtg ctt ctc gcg ttg 403 Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile Val Leu Leu Ala Leu 90 95 100 ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag ctc 451 Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr Thr Ala Gly Lys Leu 105 110 115 agc atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tca ttg 499 Ser Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu 120 125 130 cag aac ctc gat ggg cca ggt cag gac tct att cgc aca ggc caa gta 547 Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile Arg Thr Gly Gln Val 135 140 145 gtc agt cgg tcc att tcg gat atc aac atg gtg caa agc ctt gtg gcg 595 Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val Gln Ser Leu Val Ala 150 155 160 165 atg ttg ccg atg ttg atc gga aat gtg gtc aag ctt gtg ctc act ttg 643 Met Leu Pro Met Leu Ile Gly Asn Val Val Lys Leu Val Leu Thr Leu 170 175 180 gtg atc atg ctg gct att tcc ccg ccg ctg acc atc atc gct gca gtg 691 Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr Ile Ile Ala Ala Val 185 190 195 ttg gtg cct ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739 Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr Ser Arg Lys Ala Leu 200 205 210 ttt gcg tcc acg tgg tcg gcc cag caa aag gct gcg gat ctg acc act 787 Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala Ala Asp Leu Thr Thr 215 220 225 cat gtg gaa gaa act gtc acg ggt atc cgc gtg gtc aag gca ttt gcg 835 His Val Glu Glu Thr Val Thr Gly Ile Arg Val Val Lys Ala Phe Ala 230 235 240 245 cag gaa gac cgc gag acc gac aaa ttg gat ctc acc gca cgt gag tta 883 Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Ala Arg Glu Leu 250 255 260 ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc atc ccc 931 Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr Ala Lys Phe Ile Pro 265 270 275 atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979 Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn Ile Val Gly 280 285 290 ggt ggc tat ttg gcc atg act ggt cac atc acg gtg ggc acg ttt gtg 1027 Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr Val Gly Thr Phe Val 295 300 305 gcg ttt tct tcc tat ctc act agc ttg tcg gcg gtg gct agg tcc ctg 1075 Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala Val Ala Arg Ser Leu 310 315 320 325 tcg ggc atg ctc atg cgc gtg cag ttg gcg ctg tct tct gtg gag cgc 1123 Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg 330 335 340 atc ttt gaa gtc att gat ctt cag cct gaa cgc acc gat cct gca cac 1171 Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg Thr Asp Pro Ala His 345 350 355 ccc ctg tca ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219 Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val 360 365 370 gat ttc cgt ggg att ctc aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267 Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu Gly Val Gln Ala Gly 375 380 385 gaa acc gtt gtg ttg gtg ggc cct cca ggt tca ggc aag acc atg gct 1315 Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Ala 390 395 400 405 gtg cag ctt gct gga aac ttt tat caa cca gac agc ggc cac atc gcc 1363 Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp Ser Gly His Ile Ala 410 415 420 ttt gat agc aac ggc cat cgc act cgc ttc gac gac ctc acc cac agc 1411 Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser 425 430 435 gat atc cgc agg aat ctc atc gcg gtt ttt gat gag ccg ttc ttg tac 1459 Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp Glu Pro Phe Leu Tyr 440 445 450 tcc tcc tcc atc cgc gag aac atc tcg atg ggt ttg gat gtc agt gat 1507 Ser Ser Ser Ile Arg Glu Asn Ile Ser Met Gly Leu Asp Val Ser Asp 455 460 465 gag cag atc gaa cac gca gcc agg ctt gcc cag gct cat gat ttt atc 1555 Glu Gln Ile Glu His Ala Ala Arg Leu Ala Gln Ala His Asp Phe Ile 470 475 480 485 gat cgc ctt cca aac aaa tac gag gaa gtc att ggc gaa cgc ggc ctg 1603 Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val Ile Gly Glu Arg Gly Leu 490 495 500 acg ctt tct ggt ggt caa cgc caa cgc atc gcc ctc gca cgg gct ttc 1651 Thr Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala Leu Ala Arg Ala Phe 505 510 515 ctg gcg cat ccc aaa gtg ttg gtg ctt gat gat gcc acc tct gcc att 1699 Leu Ala His Pro Lys Val Leu Val Leu Asp Asp Ala Thr Ser Ala Ile 520 525 530 gat gcc tcc act gag gac cgc att ttc cag gcc ttg cgc gaa gaa ctg 1747 Asp Ala Ser Thr Glu Asp Arg Ile Phe Gln Ala Leu Arg Glu Glu Leu 535 540 545 cac gat gtc acc att ttg atc atc gcg cac cgc cac tcc act ttg gag 1795 His Asp Val Thr Ile Leu Ile Ile Ala His Arg His Ser Thr Leu Glu 550 555 560 565 ctc ggc gat cgg gtt ggt ctg gtc gaa gat gga cgg gta aca gca ctg 1843 Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly Arg Val Thr Ala Leu 570 575 580 gga ccg ttg agt gag atg cgt gat cac gct cgt ttc tcg cat ctg atg 1891 Gly Pro Leu Ser Glu Met Arg Asp His Ala Arg Phe Ser His Leu Met 585 590 595 gct ctt gat ttc cag gat tct cac gat ccg gaa ttc acc ctc gac aac 1939 Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu Phe Thr Leu Asp Asn 600 605 610 ggt tca cta ccc agc caa gag caa ttg tgg ccg gag gtc tcc aca gaa 1987 Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro Glu Val Ser Thr Glu 615 620 625 aag cag tac aag att ctt gcg cct gcc cct ggt cga ggc cgt ggc atg 2035 Lys Gln Tyr Lys Ile Leu Ala Pro Ala Pro Gly Arg Gly Arg Gly Met 630 635 640 645 tcc atg cca gca acc cct gag ctg ctc gcc cag att gag gcg ctg cca 2083 Ser Met Pro Ala Thr Pro Glu Leu Leu Ala Gln Ile Glu Ala Leu Pro 650 655 660 gca gca acg gaa gaa aca cga gtt gat gcc ggg agg cta cgc acc agt 2131 Ala Ala Thr Glu Glu Thr Arg Val Asp Ala Gly Arg Leu Arg Thr Ser 665 670 675 acc tcc ggt ttc aaa ttg ctc agt tta ttc aag cag gtc cgt tgg ctc 2179 Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys Gln Val Arg Trp Leu 680 685 690 gtc gtc gcg gtc atc gcg ttg ttg ctg gtg ggc gta gcc gcc gat cta 2227 Val Val Ala Val Ile Ala Leu Leu Leu Val Gly Val Ala Ala Asp Leu 695 700 705 gca ttt cca aca ctg atg cgc gca gcc atc gac aac ggt gtg caa gca 2275 Ala Phe Pro Thr Leu Met Arg Ala Ala Ile Asp Asn Gly Val Gln Ala 710 715 720 725 caa agc acc tcc acg ttg tgg tgg atc gcc atc gca ggc agc gta gta 2323 Gln Ser Thr Ser Thr Leu Trp Trp Ile Ala Ile Ala Gly Ser Val Val 730 735 740 gtc ctt ctg tcc tgg gcc gcc gcc gcg atc aac acg att atc acg gca 2371 Val Leu Leu Ser Trp Ala Ala Ala Ala Ile Asn Thr Ile Ile Thr Ala 745 750 755 cgc acc ggt gaa cgg ctg ctt tac ggc ttg cgt ctg cgc tca ttt gtg 2419 Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg Leu Arg Ser Phe Val 760 765 770 cat cta ttg cgc ctg tcc atg agc tat ttc gaa cgc acc atg tcc ggc 2467 His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu Arg Thr Met Ser Gly 775 780 785 cgc atc atg acg cgc atg acc acc gac atc gac aac ctc tcg tcc ttc 2515 Arg Ile Met Thr Arg Met Thr Thr Asp Ile Asp Asn Leu Ser Ser Phe 790 795 800 805 ctc caa tca ggt ctg gcg caa aca gtt gtc tct gtg ggc acg ctc atc 2563 Leu Gln Ser Gly Leu Ala Gln Thr Val Val Ser Val Gly Thr Leu Ile 810 815 820 ggt gtg gtc acc atg ctc gcc atc acc gac gca caa cta gca ctc gtt 2611 Gly Val Val Thr Met Leu Ala Ile Thr Asp Ala Gln Leu Ala Leu Val 825 830 835 gcg ctg tcc gtg gtg ccg atc atc atc gtg ctc act ctc att ttc cga 2659 Ala Leu Ser Val Val Pro Ile Ile Ile Val Leu Thr Leu Ile Phe Arg 840 845 850 cgc atc agc tcc agg ctg tac acc gct tca cgc gag caa gcc agc cag 2707 Arg Ile Ser Ser Arg Leu Tyr Thr Ala Ser Arg Glu Gln Ala Ser Gln 855 860 865 gtc aac gcg gta ttc cac gag tcc atc gcc ggt tta cgc acc gcg cag 2755 Val Asn Ala Val Phe His Glu Ser Ile Ala Gly Leu Arg Thr Ala Gln 870 875 880 885 atg cac cgc atg gaa gac caa gtc ttt gac aat tat gcg ggc gaa gca 2803 Met His Arg Met Glu Asp Gln Val Phe Asp Asn Tyr Ala Gly Glu Ala 890 895 900 gag gaa ttc cga cgc ctg cgt gtg aaa tcc cag acg gcc atc gcc atc 2851 Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln Thr Ala Ile Ala Ile 905 910 915 tac ttc ccc ggc ctt ggc gcg ctc tct gaa atc gcc cag gca ctc gtc 2899 Tyr Phe Pro Gly Leu Gly Ala Leu Ser Glu Ile Ala Gln Ala Leu Val 920 925 930 ctc ggt ttc ggc gca ctg caa gta acg cgc ggc gac atc tcc acc ggc 2947 Leu Gly Phe Gly Ala Leu Gln Val Thr Arg Gly Asp Ile Ser Thr Gly 935 940 945 gta ctc gtg gca ttc gtg ctg tac atg ggc ctg atg ttc ggc ccc atc 2995 Val Leu Val Ala Phe Val Leu Tyr Met Gly Leu Met Phe Gly Pro Ile 950 955 960 965 caa caa cta agc caa atc ttc gac tcc tac caa caa gcc gcc gtc ggc 3043 Gln Gln Leu Ser Gln Ile Phe Asp Ser Tyr Gln Gln Ala Ala Val Gly 970 975 980 ttc cgt cgc atc acc gaa ctg ctc gca acg cag ccc agc gtc cca gat 3091 Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gln Pro Ser Val Pro Asp 985 990 995 ctg ggc acc aac agg cac gct agg cag gct gcc acg cag cct tta ttg 3139 Leu Gly Thr Asn Arg His Ala Arg Gln Ala Ala Thr Gln Pro Leu Leu 1000 1005 1010 ctt gac gac gtc acc ttc ggc tat tca gac gat ccg atc cta gac aac 3187 Leu Asp Asp Val Thr Phe Gly Tyr Ser Asp Asp Pro Ile Leu Asp Asn 1015 1020 1025 gtc acc gtc cag atc gaa ccg gga acc acc gtc gct gtg gtg gga cca 3235 Val Thr Val Gln Ile Glu Pro Gly Thr Thr Val Ala Val Val Gly Pro 1030 1035 1040 1045 acc ggc gct gga aaa tcc acc gtg gtg aaa ctc ctt tcc cgc ctc tac 3283 Thr Gly Ala Gly Lys Ser Thr Val Val Lys Leu Leu Ser Arg Leu Tyr 1050 1055 1060 gac ccc aat gaa ggt gcc gtg aaa gct ggc gag atc gat atc aag gac 3331 Asp Pro Asn Glu Gly Ala Val Lys Ala Gly Glu Ile Asp Ile Lys Asp 1065 1070 1075 ttc ccc acc gct gat tgg cgc cgc aca atc ggt acc gtg cca caa gaa 3379 Phe Pro Thr Ala Asp Trp Arg Arg Thr Ile Gly Thr Val Pro Gln Glu 1080 1085 1090 gca cac ttg ttt agt gga agc atc gcc gac aac att ggc tac gga tgc 3427 Ala His Leu Phe Ser Gly Ser Ile Ala Asp Asn Ile Gly Tyr Gly Cys 1095 1100 1105 agg gag gcg tcg aca agc aaa atc gaa gcg gca gca cgc cgc gtc gga 3475 Arg Glu Ala Ser Thr Ser Lys Ile Glu Ala Ala Ala Arg Arg Val Gly 1110 1115 1120 1125 gcc tta aac gcc atc gcc gcc atc cct gat ggt ttc aac cat caa gtc 3523 Ala Leu Asn Ala Ile Ala Ala Ile Pro Asp Gly Phe Asn His Gln Val 1130 1135 1140 ggt gaa cgc ggg cgc aac ctg tca tcc gga cag cgc caa ctg atc gcg 3571 Gly Glu Arg Gly Arg Asn Leu Ser Ser Gly Gln Arg Gln Leu Ile Ala 1145 1150 1155 ctg gcg cgc gcc gaa ctt atc gag cct tcc atc atg ctt ctc gac gaa 3619 Leu Ala Arg Ala Glu Leu Ile Glu Pro Ser Ile Met Leu Leu Asp Glu 1160 1165 1170 gcc acc tcc acc ctc gac ccc gcc acc gaa gcc gtt atc ctc aac gcc 3667 Ala Thr Ser Thr Leu Asp Pro Ala Thr Glu Ala Val Ile Leu Asn Ala 1175 1180 1185 tcc gat cga gtc act aag gga cgc acc agc atc atc gtc gcg cac cgc 3715 Ser Asp Arg Val Thr Lys Gly Arg Thr Ser Ile Ile Val Ala His Arg 1190 1195 1200 1205 ttg gca acc gct aaa agg gcc gac cgt att ctt gtt gtt gaa caa gga 3763 Leu Ala Thr Ala Lys Arg Ala Asp Arg Ile Leu Val Val Glu Gln Gly 1210 1215 1220 cgt atc att gag gac gga tct cac gac gcg ttg ttg tct gct aac ggc 3811 Arg Ile Ile Glu Asp Gly Ser His Asp Ala Leu Leu Ser Ala Asn Gly 1225 1230 1235 acc tac gcc cgc atg tgg cat tta atg gcc tgacacgtta tttttaggag 3861 Thr Tyr Ala Arg Met Trp His Leu Met Ala 1240 1245 aactgtcaac 3871 <210> 118 <211> 1247 <212> PRT <213> Corynebacterium glutamicum <400> 118 Met Lys Thr Glu Gln Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala 1 5 10 15 Pro Glu Lys Pro Gln Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln 20 25 30 Arg Pro Trp Leu Thr Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr 35 40 45 Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile 50 55 60 Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg 65 70 75 80 Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile 85 90 95 Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr 100 105 110 Thr Ala Gly Lys Leu Ser Met Gly Val Gln His Asp Val Arg Leu Lys 115 120 125 Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile 130 135 140 Arg Thr Gly Gln Val Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val 145 150 155 160 Gln Ser Leu Val Ala Met Leu Pro Met Leu Ile Gly Asn Val Val Lys 165 170 175 Leu Val Leu Thr Leu Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr 180 185 190 Ile Ile Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr 195 200 205 Ser Arg Lys Ala Leu Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala 210 215 220 Ala Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly Ile Arg Val 225 230 235 240 Val Lys Ala Phe Ala Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu 245 250 255 Thr Ala Arg Glu Leu Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr 260 265 270 Ala Lys Phe Ile Pro Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val 275 280 285 Val Asn Ile Val Gly Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr 290 295 300 Val Gly Thr Phe Val Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala 305 310 315 320 Val Ala Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu 325 330 335 Ser Ser Val Glu Arg Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg 340 345 350 Thr Asp Pro Ala His Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu 355 360 365 Ser Phe Asn Asn Val Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu 370 375 380 Gly Val Gln Ala Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser 385 390 395 400 Gly Lys Thr Met Ala Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp 405 410 415 Ser Gly His Ile Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp 420 425 430 Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp 435 440 445 Glu Pro Phe Leu Tyr Ser Ser Ser Ile Arg Glu Asn Ile Ser Met Gly 450 455 460 Leu Asp Val Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu Ala Gln 465 470 475 480 Ala His Asp Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val Ile 485 490 495 Gly Glu Arg Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala 500 505 510 Leu Ala Arg Ala Phe Leu Ala His Pro Lys Val Leu Val Leu Asp Asp 515 520 525 Ala Thr Ser Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe Gln Ala 530 535 540 Leu Arg Glu Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala His Arg 545 550 555 560 His Ser Thr Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly 565 570 575 Arg Val Thr Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His Ala Arg 580 585 590 Phe Ser His Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu 595 600 605 Phe Thr Leu Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro 610 615 620 Glu Val Ser Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala Pro Gly 625 630 635 640 Arg Gly Arg Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu Ala Gln 645 650 655 Ile Glu Ala Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp Ala Gly 660 665 670 Arg Leu Arg Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys 675 680 685 Gln Val Arg Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu Val Gly 690 695 700 Val Ala Ala Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala Ile Asp 705 710 715 720 Asn Gly Val Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile Ala Ile 725 730 735 Ala Gly Ser Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala Ile Asn 740 745 750 Thr Ile Ile Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg 755 760 765 Leu Arg Ser Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu 770 775 780 Arg Thr Met Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp Ile Asp 785 790 795 800 Asn Leu Ser Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val Val Ser 805 810 815 Val Gly Thr Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr Asp Ala 820 825 830 Gln Leu Ala Leu Val Ala Leu Ser Val Val Pro Ile Ile Ile Val Leu 835 840 845 Thr Leu Ile Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala Ser Arg 850 855 860 Glu Gln Ala Ser Gln Val Asn Ala Val Phe His Glu Ser Ile Ala Gly 865 870 875 880 Leu Arg Thr Ala Gln Met His Arg Met Glu Asp Gln Val Phe Asp Asn 885 890 895 Tyr Ala Gly Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln 900 905 910 Thr Ala Ile Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser Glu Ile 915 920 925 Ala Gln Ala Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr Arg Gly 930 935 940 Asp Ile Ser Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met Gly Leu 945 950 955 960 Met Phe Gly Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser Tyr Gln 965 970 975 Gln Ala Ala Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gln 980 985 990 Pro Ser Val Pro Asp Leu Gly Thr Asn Arg His Ala Arg Gln Ala Ala 995 1000 1005 Thr Gln Pro Leu Leu Leu Asp Asp Val Thr Phe Gly Tyr Ser Asp Asp 1010 1015 1020 Pro Ile Leu Asp Asn Val Thr Val Gln Ile Glu Pro Gly Thr Thr Val 1025 1030 1035 1040 Ala Val Val Gly Pro Thr Gly Ala Gly Lys Ser Thr Val Val Lys Leu 1045 1050 1055 Leu Ser Arg Leu Tyr Asp Pro Asn Glu Gly Ala Val Lys Ala Gly Glu 1060 1065 1070 Ile Asp Ile Lys Asp Phe Pro Thr Ala Asp Trp Arg Arg Thr Ile Gly 1075 1080 1085 Thr Val Pro Gln Glu Ala His Leu Phe Ser Gly Ser Ile Ala Asp Asn 1090 1095 1100 Ile Gly Tyr Gly Cys Arg Glu Ala Ser Thr Ser Lys Ile Glu Ala Ala 1105 1110 1115 1120 Ala Arg Arg Val Gly Ala Leu Asn Ala Ile Ala Ala Ile Pro Asp Gly 1125 1130 1135 Phe Asn His Gln Val Gly Glu Arg Gly Arg Asn Leu Ser Ser Gly Gln 1140 1145 1150 Arg Gln Leu Ile Ala Leu Ala Arg Ala Glu Leu Ile Glu Pro Ser Ile 1155 1160 1165 Met Leu Leu Asp Glu Ala Thr Ser Thr Leu Asp Pro Ala Thr Glu Ala 1170 1175 1180 Val Ile Leu Asn Ala Ser Asp Arg Val Thr Lys Gly Arg Thr Ser Ile 1185 1190 1195 1200 Ile Val Ala His Arg Leu Ala Thr Ala Lys Arg Ala Asp Arg Ile Leu 1205 1210 1215 Val Val Glu Gln Gly Arg Ile Ile Glu Asp Gly Ser His Asp Ala Leu 1220 1225 1230 Leu Ser Ala Asn Gly Thr Tyr Ala Arg Met Trp His Leu Met Ala 1235 1240 1245 <210> 119 <211> 1771 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1741) <223> RXA02119 <400> 119 ttcggtccgc tctggcaaaa atggctggct gccacctcgg cgcagcagct taagggctgg 60 gcttaaattg cttgtcgacg cctagtgcca caatggagac atg acc gaa aca ctt 115 Met Thr Glu Thr Leu 1 5 gtg gtg aat ggc ctt gca ggc ggc tat ggg cac cgc aca tta ttt aac 163 Val Val Asn Gly Leu Ala Gly Gly Tyr Gly His Arg Thr Leu Phe Asn 10 15 20 gat gtg aat ctc acc gta gct gcc ggc gat gtc gtg ggc gtt gtc ggc 211 Asp Val Asn Leu Thr Val Ala Ala Gly Asp Val Val Gly Val Val Gly 25 30 35 gtc aat ggc gct ggt aaa tcc aca ttt cta aaa att ctg gcg ggc gtg 259 Val Asn Gly Ala Gly Lys Ser Thr Phe Leu Lys Ile Leu Ala Gly Val 40 45 50 gaa aag cca ctg gct gga act atc gcg ctt tcg cca gcc gat gct ttt 307 Glu Lys Pro Leu Ala Gly Thr Ile Ala Leu Ser Pro Ala Asp Ala Phe 55 60 65 gtg ggc tac ttg cca cag gaa cac acc cgc acg tct gga gag acg atc 355 Val Gly Tyr Leu Pro Gln Glu His Thr Arg Thr Ser Gly Glu Thr Ile 70 75 80 85 gca gtt tac att gct cgt cga acc ggc tgc caa gct gca aca act gcc 403 Ala Val Tyr Ile Ala Arg Arg Thr Gly Cys Gln Ala Ala Thr Thr Ala 90 95 100 atg gat gac acc gcc gaa gcg ttt ggt gcg gat cca gac aac gct gcc 451 Met Asp Asp Thr Ala Glu Ala Phe Gly Ala Asp Pro Asp Asn Ala Ala 105 110 115 ttg gcc gat gca tac gcc gag gcg ctg gat cgg tgg atg gcc agt ggc 499 Leu Ala Asp Ala Tyr Ala Glu Ala Leu Asp Arg Trp Met Ala Ser Gly 120 125 130 gca gcc gat ttg gat gaa cgc atc ccc atc gtg ctc gct gat ttg ggc 547 Ala Ala Asp Leu Asp Glu Arg Ile Pro Ile Val Leu Ala Asp Leu Gly 135 140 145 ttt gag ctt ccc acc tcg acg ctg atg gaa gga ctt tca ggc ggg cag 595 Phe Glu Leu Pro Thr Ser Thr Leu Met Glu Gly Leu Ser Gly Gly Gln 150 155 160 165 gca gcc cgg gtc ggg ctg gcg gcg tta ctg ttg tca cgt ttt gac att 643 Ala Ala Arg Val Gly Leu Ala Ala Leu Leu Leu Ser Arg Phe Asp Ile 170 175 180 gtg ctt ctc gac gag ccc acc aac gat ttg gat ctc gac ggt ctt gag 691 Val Leu Leu Asp Glu Pro Thr Asn Asp Leu Asp Leu Asp Gly Leu Glu 185 190 195 caa ctg gag aat ttt gtt cag ggg ctt cgc ggg gga gtc gta ctg gtc 739 Gln Leu Glu Asn Phe Val Gln Gly Leu Arg Gly Gly Val Val Leu Val 200 205 210 agc cat gat cgt gag ttt ctt tcc agg tgt gtg acc act gtg ctg gaa 787 Ser His Asp Arg Glu Phe Leu Ser Arg Cys Val Thr Thr Val Leu Glu 215 220 225 ctc gat ctg cac caa aat tcc cac cat gtt tat ggc ggt gga tat gat 835 Leu Asp Leu His Gln Asn Ser His His Val Tyr Gly Gly Gly Tyr Asp 230 235 240 245 tcc tac ctt gag gaa cgc gca gtg cta cgc cag cac gcc cgt gac caa 883 Ser Tyr Leu Glu Glu Arg Ala Val Leu Arg Gln His Ala Arg Asp Gln 250 255 260 tat gag gaa ttt gcg gaa aag aag aag gac ctt gtg gca cgt gct cga 931 Tyr Glu Glu Phe Ala Glu Lys Lys Lys Asp Leu Val Ala Arg Ala Arg 265 270 275 acg cag cgt gaa tgg tct agt cac ggt gtc cgc aat gct att aaa cgt 979 Thr Gln Arg Glu Trp Ser Ser His Gly Val Arg Asn Ala Ile Lys Arg 280 285 290 gca cct gac aac gac aaa ctt cgg aag aaa gcc gct gcg gaa tcc agt 1027 Ala Pro Asp Asn Asp Lys Leu Arg Lys Lys Ala Ala Ala Glu Ser Ser 295 300 305 gaa aag cag gct caa aaa gtc cgc cag atg gaa agc cgc atc gct cgg 1075 Glu Lys Gln Ala Gln Lys Val Arg Gln Met Glu Ser Arg Ile Ala Arg 310 315 320 325 tta gaa gaa gtt gaa gag cca cgt aaa gaa tgg aaa ctg cag ttc agc 1123 Leu Glu Glu Val Glu Glu Pro Arg Lys Glu Trp Lys Leu Gln Phe Ser 330 335 340 gtc ggt aag gcg tcg cgg tca agt tct gtt gtt tcc acg ttg aat gat 1171 Val Gly Lys Ala Ser Arg Ser Ser Ser Val Val Ser Thr Leu Asn Asp 345 350 355 gca agc ttc acc caa ggc gat ttc acc ttg gga cca gta tcc atc caa 1219 Ala Ser Phe Thr Gln Gly Asp Phe Thr Leu Gly Pro Val Ser Ile Gln 360 365 370 gta aat gct ggc gat cgc att ggc atc aca gga ccc aac ggt gct ggt 1267 Val Asn Ala Gly Asp Arg Ile Gly Ile Thr Gly Pro Asn Gly Ala Gly 375 380 385 aaa tcc aca ttg ctg cgc gga cta ttg gga aac caa gaa ccc acc agc 1315 Lys Ser Thr Leu Leu Arg Gly Leu Leu Gly Asn Gln Glu Pro Thr Ser 390 395 400 405 ggt act gcc acg atg ggc acg agc gtg gcg atc gga gaa atc gat cag 1363 Gly Thr Ala Thr Met Gly Thr Ser Val Ala Ile Gly Glu Ile Asp Gln 410 415 420 gca cga gcg tta ctt gat cca cag ttg cca ctg att tct gcg ttt gaa 1411 Ala Arg Ala Leu Leu Asp Pro Gln Leu Pro Leu Ile Ser Ala Phe Glu 425 430 435 aag cat gtt cca gac tta ccg atc agt gag gtg cgc aca ctg ctc gcg 1459 Lys His Val Pro Asp Leu Pro Ile Ser Glu Val Arg Thr Leu Leu Ala 440 445 450 aaa ttt ggg ctg aat gat aat cat gtg gaa cgg gac gtc gaa aag cta 1507 Lys Phe Gly Leu Asn Asp Asn His Val Glu Arg Asp Val Glu Lys Leu 455 460 465 tct cct ggc gag cgc acg cgc gcc gga ctt gcg ctg cta cag gtg cgg 1555 Ser Pro Gly Glu Arg Thr Arg Ala Gly Leu Ala Leu Leu Gln Val Arg 470 475 480 485 ggc gtc aac gtg ctt gtt ctt gat gag ccc acc aac cac ctt gac ctg 1603 Gly Val Asn Val Leu Val Leu Asp Glu Pro Thr Asn His Leu Asp Leu 490 495 500 gag gcc atc gag caa ttg gag caa gcg ttg gcc tcg tat gat ggt gtg 1651 Glu Ala Ile Glu Gln Leu Glu Gln Ala Leu Ala Ser Tyr Asp Gly Val 505 510 515 ttg ctg ctg gtc acg cac gat cgt cgc atg ttg gac gct gtg cag acc 1699 Leu Leu Leu Val Thr His Asp Arg Arg Met Leu Asp Ala Val Gln Thr 520 525 530 aat cgt cgt tgg cat gtc gag gct ggc gaa gtt agg gag cta 1741 Asn Arg Arg Trp His Val Glu Ala Gly Glu Val Arg Glu Leu 535 540 545 taaccgtttc cgtattgatg ccatggtgaa 1771 <210> 120 <211> 547 <212> PRT <213> Corynebacterium glutamicum <400> 120 Met Thr Glu Thr Leu Val Val Asn Gly Leu Ala Gly Gly Tyr Gly His 1 5 10 15 Arg Thr Leu Phe Asn Asp Val Asn Leu Thr Val Ala Ala Gly Asp Val 20 25 30 Val Gly Val Val Gly Val Asn Gly Ala Gly Lys Ser Thr Phe Leu Lys 35 40 45 Ile Leu Ala Gly Val Glu Lys Pro Leu Ala Gly Thr Ile Ala Leu Ser 50 55 60 Pro Ala Asp Ala Phe Val Gly Tyr Leu Pro Gln Glu His Thr Arg Thr 65 70 75 80 Ser Gly Glu Thr Ile Ala Val Tyr Ile Ala Arg Arg Thr Gly Cys Gln 85 90 95 Ala Ala Thr Thr Ala Met Asp Asp Thr Ala Glu Ala Phe Gly Ala Asp 100 105 110 Pro Asp Asn Ala Ala Leu Ala Asp Ala Tyr Ala Glu Ala Leu Asp Arg 115 120 125 Trp Met Ala Ser Gly Ala Ala Asp Leu Asp Glu Arg Ile Pro Ile Val 130 135 140 Leu Ala Asp Leu Gly Phe Glu Leu Pro Thr Ser Thr Leu Met Glu Gly 145 150 155 160 Leu Ser Gly Gly Gln Ala Ala Arg Val Gly Leu Ala Ala Leu Leu Leu 165 170 175 Ser Arg Phe Asp Ile Val Leu Leu Asp Glu Pro Thr Asn Asp Leu Asp 180 185 190 Leu Asp Gly Leu Glu Gln Leu Glu Asn Phe Val Gln Gly Leu Arg Gly 195 200 205 Gly Val Val Leu Val Ser His Asp Arg Glu Phe Leu Ser Arg Cys Val 210 215 220 Thr Thr Val Leu Glu Leu Asp Leu His Gln Asn Ser His His Val Tyr 225 230 235 240 Gly Gly Gly Tyr Asp Ser Tyr Leu Glu Glu Arg Ala Val Leu Arg Gln 245 250 255 His Ala Arg Asp Gln Tyr Glu Glu Phe Ala Glu Lys Lys Lys Asp Leu 260 265 270 Val Ala Arg Ala Arg Thr Gln Arg Glu Trp Ser Ser His Gly Val Arg 275 280 285 Asn Ala Ile Lys Arg Ala Pro Asp Asn Asp Lys Leu Arg Lys Lys Ala 290 295 300 Ala Ala Glu Ser Ser Glu Lys Gln Ala Gln Lys Val Arg Gln Met Glu 305 310 315 320 Ser Arg Ile Ala Arg Leu Glu Glu Val Glu Glu Pro Arg Lys Glu Trp 325 330 335 Lys Leu Gln Phe Ser Val Gly Lys Ala Ser Arg Ser Ser Ser Val Val 340 345 350 Ser Thr Leu Asn Asp Ala Ser Phe Thr Gln Gly Asp Phe Thr Leu Gly 355 360 365 Pro Val Ser Ile Gln Val Asn Ala Gly Asp Arg Ile Gly Ile Thr Gly 370 375 380 Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Arg Gly Leu Leu Gly Asn 385 390 395 400 Gln Glu Pro Thr Ser Gly Thr Ala Thr Met Gly Thr Ser Val Ala Ile 405 410 415 Gly Glu Ile Asp Gln Ala Arg Ala Leu Leu Asp Pro Gln Leu Pro Leu 420 425 430 Ile Ser Ala Phe Glu Lys His Val Pro Asp Leu Pro Ile Ser Glu Val 435 440 445 Arg Thr Leu Leu Ala Lys Phe Gly Leu Asn Asp Asn His Val Glu Arg 450 455 460 Asp Val Glu Lys Leu Ser Pro Gly Glu Arg Thr Arg Ala Gly Leu Ala 465 470 475 480 Leu Leu Gln Val Arg Gly Val Asn Val Leu Val Leu Asp Glu Pro Thr 485 490 495 Asn His Leu Asp Leu Glu Ala Ile Glu Gln Leu Glu Gln Ala Leu Ala 500 505 510 Ser Tyr Asp Gly Val Leu Leu Leu Val Thr His Asp Arg Arg Met Leu 515 520 525 Asp Ala Val Gln Thr Asn Arg Arg Trp His Val Glu Ala Gly Glu Val 530 535 540 Arg Glu Leu 545 <210> 121 <211> 1897 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1867) <223> RXA02128 <400> 121 ttgggtttgg gatgttccct caatccatct aatccgtgtt tcaattgccc tgggagtggc 60 tgtttaccct ggtattagca aaacttctta aagagccttt ttg tgc ctt tat ccg 115 Leu Cys Leu Tyr Pro 1 5 agt atc ttt aaa agc atg agt att aag tgg gcg cgc ttt gta ccg ggg 163 Ser Ile Phe Lys Ser Met Ser Ile Lys Trp Ala Arg Phe Val Pro Gly 10 15 20 ata acc gcg atg cgg ggc tat caa cga tcc tgg ttg aag ggt gat gtc 211 Ile Thr Ala Met Arg Gly Tyr Gln Arg Ser Trp Leu Lys Gly Asp Val 25 30 35 atc gcg ggt ata acc gtg gcc gcg tac ttg gtt cca caa gtc atg gct 259 Ile Ala Gly Ile Thr Val Ala Ala Tyr Leu Val Pro Gln Val Met Ala 40 45 50 tat gcc gtc att gcg ggg ctg cca gct gtc gtt ggt ctg tgg gga gtt 307 Tyr Ala Val Ile Ala Gly Leu Pro Ala Val Val Gly Leu Trp Gly Val 55 60 65 ctg gct ccc atg gcg ctg tac ttt ttc ttg ggc acg tct cga aat ctc 355 Leu Ala Pro Met Ala Leu Tyr Phe Phe Leu Gly Thr Ser Arg Asn Leu 70 75 80 85 tcg gtt ggt cct gaa tca acc acc gct ctg atg acg gct gca ggt gtg 403 Ser Val Gly Pro Glu Ser Thr Thr Ala Leu Met Thr Ala Ala Gly Val 90 95 100 gga gct tta gtc ggg gca gct ggc ggg cct gaa cga tac gca gaa gta 451 Gly Ala Leu Val Gly Ala Ala Gly Gly Pro Glu Arg Tyr Ala Glu Val 105 110 115 gcg gca cta ttg gct att gca gtg ggc att gta tgc gct gtt ggt ttt 499 Ala Ala Leu Leu Ala Ile Ala Val Gly Ile Val Cys Ala Val Gly Phe 120 125 130 att ggc cga ttg gga ttt ctt acc agg ctg ttg tct cga ccg gtg ctc 547 Ile Gly Arg Leu Gly Phe Leu Thr Arg Leu Leu Ser Arg Pro Val Leu 135 140 145 gtt gga tat ttg atc ggt att gca gtc ttg atg atc gtc agt cag ctg 595 Val Gly Tyr Leu Ile Gly Ile Ala Val Leu Met Ile Val Ser Gln Leu 150 155 160 165 tcc aaa gtc acc cag gtg aat gtg gag agc ggt cag acg tgg cag gaa 643 Ser Lys Val Thr Gln Val Asn Val Glu Ser Gly Gln Thr Trp Gln Glu 170 175 180 ata ata tcg ttt atc aaa gta gct ggc cag gca cat att cct aca gtg 691 Ile Ile Ser Phe Ile Lys Val Ala Gly Gln Ala His Ile Pro Thr Val 185 190 195 att ttg gca gtc gtg gtg ttg agc ttg ctg tat ctg gca aat tgg ttg 739 Ile Leu Ala Val Val Val Leu Ser Leu Leu Tyr Leu Ala Asn Trp Leu 200 205 210 acg cct aaa ttt ccc agc aca ctc atg gtt ctt ctg ctt tcg gca gcc 787 Thr Pro Lys Phe Pro Ser Thr Leu Met Val Leu Leu Leu Ser Ala Ala 215 220 225 gcg gtg ggg ttt ttt cat ctg gat agg ttt ggt ctt gag gtc att ggt 835 Ala Val Gly Phe Phe His Leu Asp Arg Phe Gly Leu Glu Val Ile Gly 230 235 240 245 gag gtg ccc cgt ggc ctg cct caa cca agt att ccc tcg att ggc gat 883 Glu Val Pro Arg Gly Leu Pro Gln Pro Ser Ile Pro Ser Ile Gly Asp 250 255 260 cta gag atc tgg tcg ttg ttg ccc tat gcc gtg ggt att gcc atc gtt 931 Leu Glu Ile Trp Ser Leu Leu Pro Tyr Ala Val Gly Ile Ala Ile Val 265 270 275 ggt ttt tca gac aat gtg ttg act gct cgt gca ttc gcg tcg gga aaa 979 Gly Phe Ser Asp Asn Val Leu Thr Ala Arg Ala Phe Ala Ser Gly Lys 280 285 290 gat gag gtg att gat tcc aac cag gag ctg ctc gca ctg gga acc gca 1027 Asp Glu Val Ile Asp Ser Asn Gln Glu Leu Leu Ala Leu Gly Thr Ala 295 300 305 aac ctg gcg aat ggg ttc ttc cag gga ttt cct gtg tca tcg agt ggc 1075 Asn Leu Ala Asn Gly Phe Phe Gln Gly Phe Pro Val Ser Ser Ser Gly 310 315 320 325 tcc cga act gtt ctt gga gac acg gca ggt gct cgc act cag gtg cat 1123 Ser Arg Thr Val Leu Gly Asp Thr Ala Gly Ala Arg Thr Gln Val His 330 335 340 tca ctt gtc gtg gtg gcg ctg gtg atc atg gtg ctg ttg ttt gct ggt 1171 Ser Leu Val Val Val Ala Leu Val Ile Met Val Leu Leu Phe Ala Gly 345 350 355 cct gtg ctc gag tct ttc cca gat gcg gca ctt ggc gcc tta gtt att 1219 Pro Val Leu Glu Ser Phe Pro Asp Ala Ala Leu Gly Ala Leu Val Ile 360 365 370 tat gca gca acg cag ttg att gat atc gca gag atc aaa agg atc gca 1267 Tyr Ala Ala Thr Gln Leu Ile Asp Ile Ala Glu Ile Lys Arg Ile Ala 375 380 385 cgt ttc cgc aag agc gag ttg gtc atc aca gcg gct act gct gca tcc 1315 Arg Phe Arg Lys Ser Glu Leu Val Ile Thr Ala Ala Thr Ala Ala Ser 390 395 400 405 gtt gtg gct tct ggc gtg ctc gcg ggg atc ggc gtt gcg gtt acg ttg 1363 Val Val Ala Ser Gly Val Leu Ala Gly Ile Gly Val Ala Val Thr Leu 410 415 420 tcc atc ttg gat ctc atc aga cgt att acc cga cct tat gcc gat gtc 1411 Ser Ile Leu Asp Leu Ile Arg Arg Ile Thr Arg Pro Tyr Ala Asp Val 425 430 435 cta gga tat acg ccg ggc atg gct gga atg cac agc ttg gag gat tat 1459 Leu Gly Tyr Thr Pro Gly Met Ala Gly Met His Ser Leu Glu Asp Tyr 440 445 450 cct gag tcg aca gca gtc gaa ggg ctc gtg gtt ttt aga tac gat tcc 1507 Pro Glu Ser Thr Ala Val Glu Gly Leu Val Val Phe Arg Tyr Asp Ser 455 460 465 cca ctg ttt ttc gcc aac gct gat gat ttt tcc aaa cgt gcc atc gaa 1555 Pro Leu Phe Phe Ala Asn Ala Asp Asp Phe Ser Lys Arg Ala Ile Glu 470 475 480 485 gcc gtt gat gaa gca act caa ccc gtg cat tgg ttt tta ctg aat gct 1603 Ala Val Asp Glu Ala Thr Gln Pro Val His Trp Phe Leu Leu Asn Ala 490 495 500 gaa gcg aat acg gaa gtt gat ctc acg gcc gtc gat gcc atg gaa gca 1651 Glu Ala Asn Thr Glu Val Asp Leu Thr Ala Val Asp Ala Met Glu Ala 505 510 515 ctt cgc aaa acc ctg gag gaa cgg ggt atc cga ttt gcg atg gcc cgg 1699 Leu Arg Lys Thr Leu Glu Glu Arg Gly Ile Arg Phe Ala Met Ala Arg 520 525 530 gtg aag caa gat cta cgc cga agc ctc gag cct gca ggt ttc att gaa 1747 Val Lys Gln Asp Leu Arg Arg Ser Leu Glu Pro Ala Gly Phe Ile Glu 535 540 545 tcc gtg ggg gag gag tac att ttc gcc aca ctc ccc act gca gtc aag 1795 Ser Val Gly Glu Glu Tyr Ile Phe Ala Thr Leu Pro Thr Ala Val Lys 550 555 560 565 ggg tat tcc gtg gag ttt cgc gat cgt ttt gga aac tat cca gaa ggc 1843 Gly Tyr Ser Val Glu Phe Arg Asp Arg Phe Gly Asn Tyr Pro Glu Gly 570 575 580 gtt ccg aaa gaa att ttg gaa ctt taagctgcct ggttggcgga cttagtcatg 1897 Val Pro Lys Glu Ile Leu Glu Leu 585 <210> 122 <211> 589 <212> PRT <213> Corynebacterium glutamicum <400> 122 Leu Cys Leu Tyr Pro Ser Ile Phe Lys Ser Met Ser Ile Lys Trp Ala 1 5 10 15 Arg Phe Val Pro Gly Ile Thr Ala Met Arg Gly Tyr Gln Arg Ser Trp 20 25 30 Leu Lys Gly Asp Val Ile Ala Gly Ile Thr Val Ala Ala Tyr Leu Val 35 40 45 Pro Gln Val Met Ala Tyr Ala Val Ile Ala Gly Leu Pro Ala Val Val 50 55 60 Gly Leu Trp Gly Val Leu Ala Pro Met Ala Leu Tyr Phe Phe Leu Gly 65 70 75 80 Thr Ser Arg Asn Leu Ser Val Gly Pro Glu Ser Thr Thr Ala Leu Met 85 90 95 Thr Ala Ala Gly Val Gly Ala Leu Val Gly Ala Ala Gly Gly Pro Glu 100 105 110 Arg Tyr Ala Glu Val Ala Ala Leu Leu Ala Ile Ala Val Gly Ile Val 115 120 125 Cys Ala Val Gly Phe Ile Gly Arg Leu Gly Phe Leu Thr Arg Leu Leu 130 135 140 Ser Arg Pro Val Leu Val Gly Tyr Leu Ile Gly Ile Ala Val Leu Met 145 150 155 160 Ile Val Ser Gln Leu Ser Lys Val Thr Gln Val Asn Val Glu Ser Gly 165 170 175 Gln Thr Trp Gln Glu Ile Ile Ser Phe Ile Lys Val Ala Gly Gln Ala 180 185 190 His Ile Pro Thr Val Ile Leu Ala Val Val Val Leu Ser Leu Leu Tyr 195 200 205 Leu Ala Asn Trp Leu Thr Pro Lys Phe Pro Ser Thr Leu Met Val Leu 210 215 220 Leu Leu Ser Ala Ala Ala Val Gly Phe Phe His Leu Asp Arg Phe Gly 225 230 235 240 Leu Glu Val Ile Gly Glu Val Pro Arg Gly Leu Pro Gln Pro Ser Ile 245 250 255 Pro Ser Ile Gly Asp Leu Glu Ile Trp Ser Leu Leu Pro Tyr Ala Val 260 265 270 Gly Ile Ala Ile Val Gly Phe Ser Asp Asn Val Leu Thr Ala Arg Ala 275 280 285 Phe Ala Ser Gly Lys Asp Glu Val Ile Asp Ser Asn Gln Glu Leu Leu 290 295 300 Ala Leu Gly Thr Ala Asn Leu Ala Asn Gly Phe Phe Gln Gly Phe Pro 305 310 315 320 Val Ser Ser Ser Gly Ser Arg Thr Val Leu Gly Asp Thr Ala Gly Ala 325 330 335 Arg Thr Gln Val His Ser Leu Val Val Val Ala Leu Val Ile Met Val 340 345 350 Leu Leu Phe Ala Gly Pro Val Leu Glu Ser Phe Pro Asp Ala Ala Leu 355 360 365 Gly Ala Leu Val Ile Tyr Ala Ala Thr Gln Leu Ile Asp Ile Ala Glu 370 375 380 Ile Lys Arg Ile Ala Arg Phe Arg Lys Ser Glu Leu Val Ile Thr Ala 385 390 395 400 Ala Thr Ala Ala Ser Val Val Ala Ser Gly Val Leu Ala Gly Ile Gly 405 410 415 Val Ala Val Thr Leu Ser Ile Leu Asp Leu Ile Arg Arg Ile Thr Arg 420 425 430 Pro Tyr Ala Asp Val Leu Gly Tyr Thr Pro Gly Met Ala Gly Met His 435 440 445 Ser Leu Glu Asp Tyr Pro Glu Ser Thr Ala Val Glu Gly Leu Val Val 450 455 460 Phe Arg Tyr Asp Ser Pro Leu Phe Phe Ala Asn Ala Asp Asp Phe Ser 465 470 475 480 Lys Arg Ala Ile Glu Ala Val Asp Glu Ala Thr Gln Pro Val His Trp 485 490 495 Phe Leu Leu Asn Ala Glu Ala Asn Thr Glu Val Asp Leu Thr Ala Val 500 505 510 Asp Ala Met Glu Ala Leu Arg Lys Thr Leu Glu Glu Arg Gly Ile Arg 515 520 525 Phe Ala Met Ala Arg Val Lys Gln Asp Leu Arg Arg Ser Leu Glu Pro 530 535 540 Ala Gly Phe Ile Glu Ser Val Gly Glu Glu Tyr Ile Phe Ala Thr Leu 545 550 555 560 Pro Thr Ala Val Lys Gly Tyr Ser Val Glu Phe Arg Asp Arg Phe Gly 565 570 575 Asn Tyr Pro Glu Gly Val Pro Lys Glu Ile Leu Glu Leu 580 585 <210> 123 <211> 1603 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1573) <223> RXA02173 <400> 123 attttttacg caatcgatag cctaaattgg gcttagatct tccgcctcta aataggtatg 60 cagagacatt cgaattaatt aacaaagcca tttttcggcc gtg gag aag cgt ttt 115 Val Glu Lys Arg Phe 1 5 ccg act atg gtg tgg ggc atg gaa cac act tca gca ttg acg ctc ata 163 Pro Thr Met Val Trp Gly Met Glu His Thr Ser Ala Leu Thr Leu Ile 10 15 20 gac tcg gtt ttg gac cct gac agc ttc att tct tgg aat gaa act ccc 211 Asp Ser Val Leu Asp Pro Asp Ser Phe Ile Ser Trp Asn Glu Thr Pro 25 30 35 caa tat gac aac ctc aat caa ggc tat gca gag acc ttg gag cgg gct 259 Gln Tyr Asp Asn Leu Asn Gln Gly Tyr Ala Glu Thr Leu Glu Arg Ala 40 45 50 cga agc aag gcc aaa tgc gat gaa tcg gta att act gga gaa ggc acc 307 Arg Ser Lys Ala Lys Cys Asp Glu Ser Val Ile Thr Gly Glu Gly Thr 55 60 65 gtg gag ggc att ccg gta gcc gtt att ttg tcc gat ttt tcc ttc ctc 355 Val Glu Gly Ile Pro Val Ala Val Ile Leu Ser Asp Phe Ser Phe Leu 70 75 80 85 ggc ggt tct ttg ggc acg gtc gcg tcg gtg cgc atc atg aag gcg att 403 Gly Gly Ser Leu Gly Thr Val Ala Ser Val Arg Ile Met Lys Ala Ile 90 95 100 cac cgc gcc aca gag ctg aaa ctc cca ctg ctg gtc tcc cct gct tcc 451 His Arg Ala Thr Glu Leu Lys Leu Pro Leu Leu Val Ser Pro Ala Ser 105 110 115 ggt ggt gcg cgc atg cag gaa gac aat cga gct ttt gtc atg atg gtg 499 Gly Gly Ala Arg Met Gln Glu Asp Asn Arg Ala Phe Val Met Met Val 120 125 130 tcc ata acc gcg gct gtg cag cgt cac cgc gag gcg cat ttg ccg ttc 547 Ser Ile Thr Ala Ala Val Gln Arg His Arg Glu Ala His Leu Pro Phe 135 140 145 ctg gtg tat ttg cgc aat ccc acg atg ggt ggc gcc atg gcc tcg tgg 595 Leu Val Tyr Leu Arg Asn Pro Thr Met Gly Gly Ala Met Ala Ser Trp 150 155 160 165 ggt tca tct ggg cat ctc act ttt gcg gaa ccc ggc gcg cag ata ggt 643 Gly Ser Ser Gly His Leu Thr Phe Ala Glu Pro Gly Ala Gln Ile Gly 170 175 180 ttc ctg ggt cct cgc gtg gtg gag tta acc act ggg cat gcg ctt cca 691 Phe Leu Gly Pro Arg Val Val Glu Leu Thr Thr Gly His Ala Leu Pro 185 190 195 gac ggt gtg cag cag gcg gag aat ttg gtg aaa act ggt gtg att gat 739 Asp Gly Val Gln Gln Ala Glu Asn Leu Val Lys Thr Gly Val Ile Asp 200 205 210 gga att gtg tcg cca ctc caa ttg cgt gca gcg gtg gca aaa acc ctc 787 Gly Ile Val Ser Pro Leu Gln Leu Arg Ala Ala Val Ala Lys Thr Leu 215 220 225 aag gtt att cag ccg gta gag gca acg gat cgt ttt tct cca aca act 835 Lys Val Ile Gln Pro Val Glu Ala Thr Asp Arg Phe Ser Pro Thr Thr 230 235 240 245 cct ggc gtg gca ctt ccg gtg atg gag gcg att gcg cgt tct cgt gac 883 Pro Gly Val Ala Leu Pro Val Met Glu Ala Ile Ala Arg Ser Arg Asp 250 255 260 ccg cag agg cct gga atc ggg gag att atg gaa acg ttg ggg gca gac 931 Pro Gln Arg Pro Gly Ile Gly Glu Ile Met Glu Thr Leu Gly Ala Asp 265 270 275 gtc gtc aag ctt tct ggt gcg cgt gct ggc gca ttg agc ccg gct gtg 979 Val Val Lys Leu Ser Gly Ala Arg Ala Gly Ala Leu Ser Pro Ala Val 280 285 290 cgc gtt gcc ctg gcg cgc atc ggg ggc cgg ccc gtg gtg ctg att ggg 1027 Arg Val Ala Leu Ala Arg Ile Gly Gly Arg Pro Val Val Leu Ile Gly 295 300 305 cag gat cgc cgc ttc acg ctt ggg ccg cag gag ctg cgt ttt gcg cgt 1075 Gln Asp Arg Arg Phe Thr Leu Gly Pro Gln Glu Leu Arg Phe Ala Arg 310 315 320 325 cgt ggc att tcg ctg gcg cgc gag cta aac ctg ccg atc gtg tcc atc 1123 Arg Gly Ile Ser Leu Ala Arg Glu Leu Asn Leu Pro Ile Val Ser Ile 330 335 340 atc gac acc tcc ggc gcc gaa ttg tcg cag gcg gct gag gag ctc ggc 1171 Ile Asp Thr Ser Gly Ala Glu Leu Ser Gln Ala Ala Glu Glu Leu Gly 345 350 355 atc gca agc tcg att gcg cgc acc ttg tcc aag ctt atc gac gct ccc 1219 Ile Ala Ser Ser Ile Ala Arg Thr Leu Ser Lys Leu Ile Asp Ala Pro 360 365 370 ctc ccc acc gtt tcg gtc att att ggt cag ggc gtt ggc ggt ggc gcg 1267 Leu Pro Thr Val Ser Val Ile Ile Gly Gln Gly Val Gly Gly Gly Ala 375 380 385 ctg gcc atg ctg ccc gcc gat ctg gtc tac gcg gcc gaa aac gcg tgg 1315 Leu Ala Met Leu Pro Ala Asp Leu Val Tyr Ala Ala Glu Asn Ala Trp 390 395 400 405 ctg tcc gca ttg cca cca gag ggc gcc tcg gcc atc ctc ttc cgc gac 1363 Leu Ser Ala Leu Pro Pro Glu Gly Ala Ser Ala Ile Leu Phe Arg Asp 410 415 420 acc aac cac gcc gcg gaa atc ata gag cga caa ggc gtg cag gcg cac 1411 Thr Asn His Ala Ala Glu Ile Ile Glu Arg Gln Gly Val Gln Ala His 425 430 435 gca ctt tta agc caa ggg ctt atc gac ggg atc gtc gcc gaa acc gag 1459 Ala Leu Leu Ser Gln Gly Leu Ile Asp Gly Ile Val Ala Glu Thr Glu 440 445 450 cac ttt gtt gaa gaa att ctc ggc aca atc agc aac gcc ctc tcc gaa 1507 His Phe Val Glu Glu Ile Leu Gly Thr Ile Ser Asn Ala Leu Ser Glu 455 460 465 ttg gat aac aat ccg gag agg gcg gga cgc gac agt cgc ttc aca cga 1555 Leu Asp Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe Thr Arg 470 475 480 485 ttt gag cgt tta gcg cag taaagaaaat tatgcgctga tcaaatcgat 1603 Phe Glu Arg Leu Ala Gln 490 <210> 124 <211> 491 <212> PRT <213> Corynebacterium glutamicum <400> 124 Val Glu Lys Arg Phe Pro Thr Met Val Trp Gly Met Glu His Thr Ser 1 5 10 15 Ala Leu Thr Leu Ile Asp Ser Val Leu Asp Pro Asp Ser Phe Ile Ser 20 25 30 Trp Asn Glu Thr Pro Gln Tyr Asp Asn Leu Asn Gln Gly Tyr Ala Glu 35 40 45 Thr Leu Glu Arg Ala Arg Ser Lys Ala Lys Cys Asp Glu Ser Val Ile 50 55 60 Thr Gly Glu Gly Thr Val Glu Gly Ile Pro Val Ala Val Ile Leu Ser 65 70 75 80 Asp Phe Ser Phe Leu Gly Gly Ser Leu Gly Thr Val Ala Ser Val Arg 85 90 95 Ile Met Lys Ala Ile His Arg Ala Thr Glu Leu Lys Leu Pro Leu Leu 100 105 110 Val Ser Pro Ala Ser Gly Gly Ala Arg Met Gln Glu Asp Asn Arg Ala 115 120 125 Phe Val Met Met Val Ser Ile Thr Ala Ala Val Gln Arg His Arg Glu 130 135 140 Ala His Leu Pro Phe Leu Val Tyr Leu Arg Asn Pro Thr Met Gly Gly 145 150 155 160 Ala Met Ala Ser Trp Gly Ser Ser Gly His Leu Thr Phe Ala Glu Pro 165 170 175 Gly Ala Gln Ile Gly Phe Leu Gly Pro Arg Val Val Glu Leu Thr Thr 180 185 190 Gly His Ala Leu Pro Asp Gly Val Gln Gln Ala Glu Asn Leu Val Lys 195 200 205 Thr Gly Val Ile Asp Gly Ile Val Ser Pro Leu Gln Leu Arg Ala Ala 210 215 220 Val Ala Lys Thr Leu Lys Val Ile Gln Pro Val Glu Ala Thr Asp Arg 225 230 235 240 Phe Ser Pro Thr Thr Pro Gly Val Ala Leu Pro Val Met Glu Ala Ile 245 250 255 Ala Arg Ser Arg Asp Pro Gln Arg Pro Gly Ile Gly Glu Ile Met Glu 260 265 270 Thr Leu Gly Ala Asp Val Val Lys Leu Ser Gly Ala Arg Ala Gly Ala 275 280 285 Leu Ser Pro Ala Val Arg Val Ala Leu Ala Arg Ile Gly Gly Arg Pro 290 295 300 Val Val Leu Ile Gly Gln Asp Arg Arg Phe Thr Leu Gly Pro Gln Glu 305 310 315 320 Leu Arg Phe Ala Arg Arg Gly Ile Ser Leu Ala Arg Glu Leu Asn Leu 325 330 335 Pro Ile Val Ser Ile Ile Asp Thr Ser Gly Ala Glu Leu Ser Gln Ala 340 345 350 Ala Glu Glu Leu Gly Ile Ala Ser Ser Ile Ala Arg Thr Leu Ser Lys 355 360 365 Leu Ile Asp Ala Pro Leu Pro Thr Val Ser Val Ile Ile Gly Gln Gly 370 375 380 Val Gly Gly Gly Ala Leu Ala Met Leu Pro Ala Asp Leu Val Tyr Ala 385 390 395 400 Ala Glu Asn Ala Trp Leu Ser Ala Leu Pro Pro Glu Gly Ala Ser Ala 405 410 415 Ile Leu Phe Arg Asp Thr Asn His Ala Ala Glu Ile Ile Glu Arg Gln 420 425 430 Gly Val Gln Ala His Ala Leu Leu Ser Gln Gly Leu Ile Asp Gly Ile 435 440 445 Val Ala Glu Thr Glu His Phe Val Glu Glu Ile Leu Gly Thr Ile Ser 450 455 460 Asn Ala Leu Ser Glu Leu Asp Asn Asn Pro Glu Arg Ala Gly Arg Asp 465 470 475 480 Ser Arg Phe Thr Arg Phe Glu Arg Leu Ala Gln 485 490 <210> 125 <211> 2806 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2776) <223> RXA02220 <400> 125 gggctttcgc cgcggaatgg tccctcgtcc aggtctttaa ttgatgtctt gacgtgatct 60 gggcgggcac gcggccaatc atgtgaaagg tctgttttag gtg tcg tcc cct ctc 115 Val Ser Ser Pro Leu 1 5 ccc gct gcc gtc aca tca aaa ccc gcc cac gcg ctt tcc tct gat gag 163 Pro Ala Ala Val Thr Ser Lys Pro Ala His Ala Leu Ser Ser Asp Glu 10 15 20 gtg tta gaa aat ctc ggg gtc cag gac acc gga ttg acc tcc gcg gag 211 Val Leu Glu Asn Leu Gly Val Gln Asp Thr Gly Leu Thr Ser Ala Glu 25 30 35 gca aca cag cgt ttg gaa gca aac ggg cca aac gag ctt cct caa act 259 Ala Thr Gln Arg Leu Glu Ala Asn Gly Pro Asn Glu Leu Pro Gln Thr 40 45 50 cca cct gaa aca gtc tgg caa cgg cta ttc cgc cag gtc aac gat cca 307 Pro Pro Glu Thr Val Trp Gln Arg Leu Phe Arg Gln Val Asn Asp Pro 55 60 65 atg atc tac gtt ctc att gcc gcc gcg gta ctc acg gcg ttt ctt ggg 355 Met Ile Tyr Val Leu Ile Ala Ala Ala Val Leu Thr Ala Phe Leu Gly 70 75 80 85 cat tgg aca gac acc atc gtg atc ggc gcc gtt gtc atc atc aac atg 403 His Trp Thr Asp Thr Ile Val Ile Gly Ala Val Val Ile Ile Asn Met 90 95 100 atg gtt ggg ttc atc caa gag ggc aaa gct gcg gat gcg ttg gca tcg 451 Met Val Gly Phe Ile Gln Glu Gly Lys Ala Ala Asp Ala Leu Ala Ser 105 110 115 atc cgc aac atg ctc tcc ccg gaa tcc gcg gcg ttg cgc gat ggg gtc 499 Ile Arg Asn Met Leu Ser Pro Glu Ser Ala Ala Leu Arg Asp Gly Val 120 125 130 ttc cac aaa att gat gcg gca gag ctg gtg gtc ggt gac gtt gtg aaa 547 Phe His Lys Ile Asp Ala Ala Glu Leu Val Val Gly Asp Val Val Lys 135 140 145 cta tcc gcc ggc gat aaa gtg ccc gct gac ctg cgc atg ctc gcc gcc 595 Leu Ser Ala Gly Asp Lys Val Pro Ala Asp Leu Arg Met Leu Ala Ala 150 155 160 165 acc aat ctg cac att gag gaa tcc gcg ctc acc ggc gag gcg gaa gca 643 Thr Asn Leu His Ile Glu Glu Ser Ala Leu Thr Gly Glu Ala Glu Ala 170 175 180 gtg gtc aaa ggt act gat cca gtt gag gcc gac gcc gga atc ggc gac 691 Val Val Lys Gly Thr Asp Pro Val Glu Ala Asp Ala Gly Ile Gly Asp 185 190 195 cgc aca tcc atg gcg ttt tca gga acg ctg gtg ctc aca ggc agc ggc 739 Arg Thr Ser Met Ala Phe Ser Gly Thr Leu Val Leu Thr Gly Ser Gly 200 205 210 acc ggc gtg gtc acc gcc acc ggt gca ggc aca gaa atc ggg cac atc 787 Thr Gly Val Val Thr Ala Thr Gly Ala Gly Thr Glu Ile Gly His Ile 215 220 225 acc acc atg ctt gcc gac gtc gac tcc gtg gat acc cca ttg act cgg 835 Thr Thr Met Leu Ala Asp Val Asp Ser Val Asp Thr Pro Leu Thr Arg 230 235 240 245 tcg atg aaa aag ttc tca tcg gcg tta gca atc gtg tgt gta ttc cta 883 Ser Met Lys Lys Phe Ser Ser Ala Leu Ala Ile Val Cys Val Phe Leu 250 255 260 gcg atc ctc atg ctg gtg gtt gcc ggt cta gtc cac cac aca cct ttg 931 Ala Ile Leu Met Leu Val Val Ala Gly Leu Val His His Thr Pro Leu 265 270 275 gaa gag ctc att ctt tcc gcc atc ggc ttt gcg gtg gct gcc att ccg 979 Glu Glu Leu Ile Leu Ser Ala Ile Gly Phe Ala Val Ala Ala Ile Pro 280 285 290 gag ggt cta cct gcg gtt atc gcc atc acg ctg gca ttg ggt gtg caa 1027 Glu Gly Leu Pro Ala Val Ile Ala Ile Thr Leu Ala Leu Gly Val Gln 295 300 305 aag atg gca gct cga aat gcg att acg cgc cgg ttg aat tcc gtg gaa 1075 Lys Met Ala Ala Arg Asn Ala Ile Thr Arg Arg Leu Asn Ser Val Glu 310 315 320 325 aca ctt ggc tct gtc acc acc atc tgc acg gat aaa acc ggc aca ctc 1123 Thr Leu Gly Ser Val Thr Thr Ile Cys Thr Asp Lys Thr Gly Thr Leu 330 335 340 acc cgc aat gag atg aca gtc cgc gca atc gcc acc ggt acg agt ctt 1171 Thr Arg Asn Glu Met Thr Val Arg Ala Ile Ala Thr Gly Thr Ser Leu 345 350 355 tat gac gtc agt gga gca ggc tac gaa cct ctc ggg gaa atc cgc tta 1219 Tyr Asp Val Ser Gly Ala Gly Tyr Glu Pro Leu Gly Glu Ile Arg Leu 360 365 370 aaa gac ggc gag caa gta tcc aag cag gat ttc cca gat ctc tac gcc 1267 Lys Asp Gly Glu Gln Val Ser Lys Gln Asp Phe Pro Asp Leu Tyr Ala 375 380 385 atg gcg ttg gtc gca gcg aac gtc aac gac gcc gaa att tac caa gaa 1315 Met Ala Leu Val Ala Ala Asn Val Asn Asp Ala Glu Ile Tyr Gln Glu 390 395 400 405 gac ggc atg tgg agg ctt tcc ggc gaa ccc acc gac ggc ggt att cgt 1363 Asp Gly Met Trp Arg Leu Ser Gly Glu Pro Thr Asp Gly Gly Ile Arg 410 415 420 gcc ttt gca atg aaa acc aac gct gaa atc ttg acc cga aca gcc gaa 1411 Ala Phe Ala Met Lys Thr Asn Ala Glu Ile Leu Thr Arg Thr Ala Glu 425 430 435 gtc ccc ttc gat tcc gca tac aaa tac atg gcg acg ctt cac acc atc 1459 Val Pro Phe Asp Ser Ala Tyr Lys Tyr Met Ala Thr Leu His Thr Ile 440 445 450 gat gga gca aac acc atg ctg gtc aag ggc gct ccc gat cgt tta ttg 1507 Asp Gly Ala Asn Thr Met Leu Val Lys Gly Ala Pro Asp Arg Leu Leu 455 460 465 gat aga agt gca cag cag cgc aac ggt gaa cca ctt gac cgg ccg tat 1555 Asp Arg Ser Ala Gln Gln Arg Asn Gly Glu Pro Leu Asp Arg Pro Tyr 470 475 480 485 tgg gaa cag ctc atc gag gac ctc gcg tcc caa ggc ctc cgc gtg ctg 1603 Trp Glu Gln Leu Ile Glu Asp Leu Ala Ser Gln Gly Leu Arg Val Leu 490 495 500 gct gcg gca tat aaa gag ctt ccc cac agc acg tca aca att act cca 1651 Ala Ala Ala Tyr Lys Glu Leu Pro His Ser Thr Ser Thr Ile Thr Pro 505 510 515 gaa gat gtt gac cag ggc gaa ctc acc ttc ctc ggg ctc tac ggc atc 1699 Glu Asp Val Asp Gln Gly Glu Leu Thr Phe Leu Gly Leu Tyr Gly Ile 520 525 530 atg gat ccg cca cgc gaa gaa gtc atc gaa gcc atg aaa gtg gtg caa 1747 Met Asp Pro Pro Arg Glu Glu Val Ile Glu Ala Met Lys Val Val Gln 535 540 545 tcg gca ggc gtt cgc gtc cgc atg atc acc ggc gat cac tcc tcc acg 1795 Ser Ala Gly Val Arg Val Arg Met Ile Thr Gly Asp His Ser Ser Thr 550 555 560 565 gcc cgc gca atc gcc cgc gaa gtg gga atc cgc ggc cag aac gtg ctc 1843 Ala Arg Ala Ile Ala Arg Glu Val Gly Ile Arg Gly Gln Asn Val Leu 570 575 580 acc ggt gcg gaa att act gcg gct acg gat gag gag ctg cag gga ctc 1891 Thr Gly Ala Glu Ile Thr Ala Ala Thr Asp Glu Glu Leu Gln Gly Leu 585 590 595 gtc gat aat gct gat ctt ttt gtg cgc acc agc ccc gag cac aag ctg 1939 Val Asp Asn Ala Asp Leu Phe Val Arg Thr Ser Pro Glu His Lys Leu 600 605 610 cgc gtc gtg cgc gca ctg caa gct aac ggc gaa gtc gcg tcc atg acc 1987 Arg Val Val Arg Ala Leu Gln Ala Asn Gly Glu Val Ala Ser Met Thr 615 620 625 ggc gac ggc gtc aac gat gcg cca gcg cta aaa caa gcc gac gtc ggc 2035 Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Gln Ala Asp Val Gly 630 635 640 645 gtc gcc atg ggc att aag ggc acc gaa gcc acc aaa gac gcg gcc gac 2083 Val Ala Met Gly Ile Lys Gly Thr Glu Ala Thr Lys Asp Ala Ala Asp 650 655 660 atc gtg ctt gcc gac gac aat ttc gcc aca atc gcc ggc gcc gta gaa 2131 Ile Val Leu Ala Asp Asp Asn Phe Ala Thr Ile Ala Gly Ala Val Glu 665 670 675 atg ggt cgc acc atc tac gac aac ctg cgc aaa gcc gtc gtc ttc atg 2179 Met Gly Arg Thr Ile Tyr Asp Asn Leu Arg Lys Ala Val Val Phe Met 680 685 690 ctc ccc acc aac ggc gcc caa ggc ctc gtc att ttc atc gcg atg ctg 2227 Leu Pro Thr Asn Gly Ala Gln Gly Leu Val Ile Phe Ile Ala Met Leu 695 700 705 ctc ggc tgg gaa ctg ccc atc acc gca ctt caa gtg ctg tgg atc aac 2275 Leu Gly Trp Glu Leu Pro Ile Thr Ala Leu Gln Val Leu Trp Ile Asn 710 715 720 725 ctc atc acc gcc atc aca ctg tcc ctg gcg ctg tcc ttc gag ccg gcc 2323 Leu Ile Thr Ala Ile Thr Leu Ser Leu Ala Leu Ser Phe Glu Pro Ala 730 735 740 gag ccc ggc atc atg aac aga aaa ccc aga aac ccc aag agc ggg ctt 2371 Glu Pro Gly Ile Met Asn Arg Lys Pro Arg Asn Pro Lys Ser Gly Leu 745 750 755 atc gac gcc ccc tcc gtg ctt cgc atc gtc tat gtc tcc ctg ctg ctc 2419 Ile Asp Ala Pro Ser Val Leu Arg Ile Val Tyr Val Ser Leu Leu Leu 760 765 770 ggc gga gca acg ttc tgg gct ttc ctt ggc gcc cgc gac gca gga atc 2467 Gly Gly Ala Thr Phe Trp Ala Phe Leu Gly Ala Arg Asp Ala Gly Ile 775 780 785 gac atc gac acc gcc cgc acc atc gcg gtc acc acc ctt gca gtc agc 2515 Asp Ile Asp Thr Ala Arg Thr Ile Ala Val Thr Thr Leu Ala Val Ser 790 795 800 805 caa gtg ttc tac ctt tta agc tcc cga tac ttc gaa gta tcc gcg ctg 2563 Gln Val Phe Tyr Leu Leu Ser Ser Arg Tyr Phe Glu Val Ser Ala Leu 810 815 820 cga aaa gaa ctc ttc acc acc aac ccg att tcc tgg ctg tgc atc gca 2611 Arg Lys Glu Leu Phe Thr Thr Asn Pro Ile Ser Trp Leu Cys Ile Ala 825 830 835 ctc atg ctg atc ctg caa ctg gcc ttt gtc tac ctg ccg ttc atg caa 2659 Leu Met Leu Ile Leu Gln Leu Ala Phe Val Tyr Leu Pro Phe Met Gln 840 845 850 agc acc ttc gac acc gcc gca ctg acg ctt aga gat tgg gtc atg cca 2707 Ser Thr Phe Asp Thr Ala Ala Leu Thr Leu Arg Asp Trp Val Met Pro 855 860 865 ctg gtg ttt ggt gtt gtt gtc ttt gcg gtc gtt gaa acc gag aaa ttc 2755 Leu Val Phe Gly Val Val Val Phe Ala Val Val Glu Thr Glu Lys Phe 870 875 880 885 atc agg cgc ctt aaa gcg tct taaggtttca gcccctcaag atacttgtcg 2806 Ile Arg Arg Leu Lys Ala Ser 890 <210> 126 <211> 892 <212> PRT <213> Corynebacterium glutamicum <400> 126 Val Ser Ser Pro Leu Pro Ala Ala Val Thr Ser Lys Pro Ala His Ala 1 5 10 15 Leu Ser Ser Asp Glu Val Leu Glu Asn Leu Gly Val Gln Asp Thr Gly 20 25 30 Leu Thr Ser Ala Glu Ala Thr Gln Arg Leu Glu Ala Asn Gly Pro Asn 35 40 45 Glu Leu Pro Gln Thr Pro Pro Glu Thr Val Trp Gln Arg Leu Phe Arg 50 55 60 Gln Val Asn Asp Pro Met Ile Tyr Val Leu Ile Ala Ala Ala Val Leu 65 70 75 80 Thr Ala Phe Leu Gly His Trp Thr Asp Thr Ile Val Ile Gly Ala Val 85 90 95 Val Ile Ile Asn Met Met Val Gly Phe Ile Gln Glu Gly Lys Ala Ala 100 105 110 Asp Ala Leu Ala Ser Ile Arg Asn Met Leu Ser Pro Glu Ser Ala Ala 115 120 125 Leu Arg Asp Gly Val Phe His Lys Ile Asp Ala Ala Glu Leu Val Val 130 135 140 Gly Asp Val Val Lys Leu Ser Ala Gly Asp Lys Val Pro Ala Asp Leu 145 150 155 160 Arg Met Leu Ala Ala Thr Asn Leu His Ile Glu Glu Ser Ala Leu Thr 165 170 175 Gly Glu Ala Glu Ala Val Val Lys Gly Thr Asp Pro Val Glu Ala Asp 180 185 190 Ala Gly Ile Gly Asp Arg Thr Ser Met Ala Phe Ser Gly Thr Leu Val 195 200 205 Leu Thr Gly Ser Gly Thr Gly Val Val Thr Ala Thr Gly Ala Gly Thr 210 215 220 Glu Ile Gly His Ile Thr Thr Met Leu Ala Asp Val Asp Ser Val Asp 225 230 235 240 Thr Pro Leu Thr Arg Ser Met Lys Lys Phe Ser Ser Ala Leu Ala Ile 245 250 255 Val Cys Val Phe Leu Ala Ile Leu Met Leu Val Val Ala Gly Leu Val 260 265 270 His His Thr Pro Leu Glu Glu Leu Ile Leu Ser Ala Ile Gly Phe Ala 275 280 285 Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Ala Ile Thr Leu 290 295 300 Ala Leu Gly Val Gln Lys Met Ala Ala Arg Asn Ala Ile Thr Arg Arg 305 310 315 320 Leu Asn Ser Val Glu Thr Leu Gly Ser Val Thr Thr Ile Cys Thr Asp 325 330 335 Lys Thr Gly Thr Leu Thr Arg Asn Glu Met Thr Val Arg Ala Ile Ala 340 345 350 Thr Gly Thr Ser Leu Tyr Asp Val Ser Gly Ala Gly Tyr Glu Pro Leu 355 360 365 Gly Glu Ile Arg Leu Lys Asp Gly Glu Gln Val Ser Lys Gln Asp Phe 370 375 380 Pro Asp Leu Tyr Ala Met Ala Leu Val Ala Ala Asn Val Asn Asp Ala 385 390 395 400 Glu Ile Tyr Gln Glu Asp Gly Met Trp Arg Leu Ser Gly Glu Pro Thr 405 410 415 Asp Gly Gly Ile Arg Ala Phe Ala Met Lys Thr Asn Ala Glu Ile Leu 420 425 430 Thr Arg Thr Ala Glu Val Pro Phe Asp Ser Ala Tyr Lys Tyr Met Ala 435 440 445 Thr Leu His Thr Ile Asp Gly Ala Asn Thr Met Leu Val Lys Gly Ala 450 455 460 Pro Asp Arg Leu Leu Asp Arg Ser Ala Gln Gln Arg Asn Gly Glu Pro 465 470 475 480 Leu Asp Arg Pro Tyr Trp Glu Gln Leu Ile Glu Asp Leu Ala Ser Gln 485 490 495 Gly Leu Arg Val Leu Ala Ala Ala Tyr Lys Glu Leu Pro His Ser Thr 500 505 510 Ser Thr Ile Thr Pro Glu Asp Val Asp Gln Gly Glu Leu Thr Phe Leu 515 520 525 Gly Leu Tyr Gly Ile Met Asp Pro Pro Arg Glu Glu Val Ile Glu Ala 530 535 540 Met Lys Val Val Gln Ser Ala Gly Val Arg Val Arg Met Ile Thr Gly 545 550 555 560 Asp His Ser Ser Thr Ala Arg Ala Ile Ala Arg Glu Val Gly Ile Arg 565 570 575 Gly Gln Asn Val Leu Thr Gly Ala Glu Ile Thr Ala Ala Thr Asp Glu 580 585 590 Glu Leu Gln Gly Leu Val Asp Asn Ala Asp Leu Phe Val Arg Thr Ser 595 600 605 Pro Glu His Lys Leu Arg Val Val Arg Ala Leu Gln Ala Asn Gly Glu 610 615 620 Val Ala Ser Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys 625 630 635 640 Gln Ala Asp Val Gly Val Ala Met Gly Ile Lys Gly Thr Glu Ala Thr 645 650 655 Lys Asp Ala Ala Asp Ile Val Leu Ala Asp Asp Asn Phe Ala Thr Ile 660 665 670 Ala Gly Ala Val Glu Met Gly Arg Thr Ile Tyr Asp Asn Leu Arg Lys 675 680 685 Ala Val Val Phe Met Leu Pro Thr Asn Gly Ala Gln Gly Leu Val Ile 690 695 700 Phe Ile Ala Met Leu Leu Gly Trp Glu Leu Pro Ile Thr Ala Leu Gln 705 710 715 720 Val Leu Trp Ile Asn Leu Ile Thr Ala Ile Thr Leu Ser Leu Ala Leu 725 730 735 Ser Phe Glu Pro Ala Glu Pro Gly Ile Met Asn Arg Lys Pro Arg Asn 740 745 750 Pro Lys Ser Gly Leu Ile Asp Ala Pro Ser Val Leu Arg Ile Val Tyr 755 760 765 Val Ser Leu Leu Leu Gly Gly Ala Thr Phe Trp Ala Phe Leu Gly Ala 770 775 780 Arg Asp Ala Gly Ile Asp Ile Asp Thr Ala Arg Thr Ile Ala Val Thr 785 790 795 800 Thr Leu Ala Val Ser Gln Val Phe Tyr Leu Leu Ser Ser Arg Tyr Phe 805 810 815 Glu Val Ser Ala Leu Arg Lys Glu Leu Phe Thr Thr Asn Pro Ile Ser 820 825 830 Trp Leu Cys Ile Ala Leu Met Leu Ile Leu Gln Leu Ala Phe Val Tyr 835 840 845 Leu Pro Phe Met Gln Ser Thr Phe Asp Thr Ala Ala Leu Thr Leu Arg 850 855 860 Asp Trp Val Met Pro Leu Val Phe Gly Val Val Val Phe Ala Val Val 865 870 875 880 Glu Thr Glu Lys Phe Ile Arg Arg Leu Lys Ala Ser 885 890 <210> 127 <211> 1417 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1387) <223> RXA02233 <400> 127 atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60 ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115 Val Leu Val Thr Ser 1 5 aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163 Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly 10 15 20 gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211 Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly 25 30 35 atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259 Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val 40 45 50 ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307 Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly 55 60 65 ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355 Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser 70 75 80 85 tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403 Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln 90 95 100 gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451 Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu 105 110 115 gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499 Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val 120 125 130 att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547 Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu 135 140 145 atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595 Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln 150 155 160 165 cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643 Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val 170 175 180 gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691 Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val 185 190 195 atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739 Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala 200 205 210 gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787 Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His 215 220 225 aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835 Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile 230 235 240 245 atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883 Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu 250 255 260 atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931 Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala 265 270 275 gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979 Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr 280 285 290 acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027 Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr 295 300 305 tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075 Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala 310 315 320 325 ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123 Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val 330 335 340 ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171 Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly 345 350 355 att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219 Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn 360 365 370 ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267 Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr 375 380 385 ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg ggc tct gta 1315 Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Gly Ser Val 390 395 400 405 ggc atc att gtg ctg tac cca atc atg aag cgc ctg tac ctt tcc att 1363 Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg Leu Tyr Leu Ser Ile 410 415 420 ggg gaa ggc aag aac gca aag ttc tagtacgctg ctaaagtatg cagcttggcc 1417 Gly Glu Gly Lys Asn Ala Lys Phe 425 <210> 128 <211> 429 <212> PRT <213> Corynebacterium glutamicum <400> 128 Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys 1 5 10 15 Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp 20 25 30 Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly 35 40 45 Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr 50 55 60 Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg 65 70 75 80 Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro 85 90 95 Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile 100 105 110 Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala 115 120 125 Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly 130 135 140 Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly 145 150 155 160 Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile 165 170 175 Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile 180 185 190 Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn 195 200 205 Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly 210 215 220 Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val 225 230 235 240 Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val 245 250 255 Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly 260 265 270 Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe 275 280 285 Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala 290 295 300 Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr 305 310 315 320 Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr 325 330 335 Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu 340 345 350 Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe 355 360 365 Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly 370 375 380 Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile 385 390 395 400 Ala Trp Gly Ser Val Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg 405 410 415 Leu Tyr Leu Ser Ile Gly Glu Gly Lys Asn Ala Lys Phe 420 425 <210> 129 <211> 1180 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1150) <223> RXA02309 <400> 129 gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60 aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115 Met Ser Ser Gly Arg 1 5 acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163 Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr 10 15 20 aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211 Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg 25 30 35 atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259 Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu 40 45 50 tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307 Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg 55 60 65 gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355 Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu 70 75 80 85 ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403 Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val 90 95 100 gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451 Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp 105 110 115 gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499 Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp 120 125 130 aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547 Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser 135 140 145 ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595 Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu 150 155 160 165 aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643 Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro 170 175 180 cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691 Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys 185 190 195 act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739 Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala 200 205 210 ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787 Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala 215 220 225 gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835 Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser 230 235 240 245 gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883 Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly 250 255 260 gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931 Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val 265 270 275 ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979 Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu 280 285 290 acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027 Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln 295 300 305 gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075 Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu 310 315 320 325 ctc gac cgc ctc cca gac agc acc gtc aag gaa gcc ctc cgc aac ctt 1123 Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu Ala Leu Arg Asn Leu 330 335 340 gca acc ttc aca gtc aag cgc gtc gga taaccccgta atccaccact 1170 Ala Thr Phe Thr Val Lys Arg Val Gly 345 350 taacctgccg 1180 <210> 130 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 130 Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys 1 5 10 15 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro 20 25 30 Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu 35 40 45 Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val 50 55 60 Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala 65 70 75 80 Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile 85 90 95 Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His 100 105 110 Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala 115 120 125 Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu 130 135 140 Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn 180 185 190 Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu 195 200 205 Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys 210 215 220 Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile 225 230 235 240 Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg 260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro 275 280 285 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln 290 295 300 Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 Ile Ala Asn Ala Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu 325 330 335 Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly 340 345 350 <210> 131 <211> 1903 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1873) <223> RXA02335 <400> 131 tggttgagtt cttcggggtt gagtgtgcaa gaatattcac tattggtcag gcaactatgt 60 gtctacccac tgagtcatca atttaaatca ggagttatta gtg tca gtc gag act 115 Val Ser Val Glu Thr 1 5 agg aag atc acc aag gtt ctt gtc gct aac cgt ggt gag att gca atc 163 Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg Gly Glu Ile Ala Ile 10 15 20 cgc gtg ttc cgt gca gct cga gat gaa ggc atc gga tct gtc gcc gtc 211 Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Ile Gly Ser Val Ala Val 25 30 35 tac gca gag cca gat gca gat gca cca ttc gtg tca tat gca gac gag 259 Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val Ser Tyr Ala Asp Glu 40 45 50 gct ttt gcc ctc ggt ggc caa aca tcc gct gag tcc tac ctt gtc att 307 Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu Ser Tyr Leu Val Ile 55 60 65 gac aag atc atc gat gcg gcc cgc aag tcc ggc gcc gac gcc atc cac 355 Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly Ala Asp Ala Ile His 70 75 80 85 ccc ggc tac ggc ttc ctc gca gaa aac gct gac ttc gca gaa gca gtc 403 Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp Phe Ala Glu Ala Val 90 95 100 atc aac gaa ggc ctg atc tgg att gga cct tca cct gag tcc atc cgc 451 Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser Pro Glu Ser Ile Arg 105 110 115 tcc ctc ggc gac aag gtc acc gct cgc cac atc gca gat acc gcc aag 499 Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile Ala Asp Thr Ala Lys 120 125 130 gct cca atg gct cct ggc acc aag gaa cca gta aaa gac gca gca gaa 547 Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val Lys Asp Ala Ala Glu 135 140 145 gtt gtg gct ttc gct gaa gaa ttc ggt ctc cca atc gcc atc aag gca 595 Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro Ile Ala Ile Lys Ala 150 155 160 165 gct ttc ggt ggc ggc gga cgt ggc atg aag gtt gcc tac aag atg gaa 643 Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val Ala Tyr Lys Met Glu 170 175 180 gaa gtc gct gac ctc ttc gag tcc gca acc cgt gaa gca acc gca gcg 691 Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg Glu Ala Thr Ala Ala 185 190 195 ttc ggc cgc ggc gag tgc ttc gtg gag cgc tac ctg gac aag gca cgc 739 Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr Leu Asp Lys Ala Arg 200 205 210 cac gtt gag gct cag gtc atc gcc gat aag cac ggc aac gtt gtt gtc 787 His Val Glu Ala Gln Val Ile Ala Asp Lys His Gly Asn Val Val Val 215 220 225 gcc gga acc cgt gac tgc tcc ctg cag cgc cgt ttc cag aag ctc gtc 835 Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg Phe Gln Lys Leu Val 230 235 240 245 gaa gaa gca cca gca cca ttc ctc acc gat gac cag cgc gag cgt ctc 883 Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp Gln Arg Glu Arg Leu 250 255 260 cac tcc tcc gcg aag gct atc tgt aag gaa gct ggc tac tac ggt gca 931 His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala Gly Tyr Tyr Gly Ala 265 270 275 ggc acc gtt gag tac ctc gtt ggc tcc gac ggc ctg atc tcc ttc ctc 979 Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly Leu Ile Ser Phe Leu 280 285 290 gag gtc aac acc cgc ctc cag gtg gaa cac cca gtc acc gaa gag acc 1027 Glu Val Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Glu Thr 295 300 305 acc ggc atc gac ctg gtc cgc gaa atg ttc cgc atc gca gaa ggc cac 1075 Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg Ile Ala Glu Gly His 310 315 320 325 gag ctc tcc atc aag gaa gat cca gct cca cgc ggc cac gca ttc gag 1123 Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg Gly His Ala Phe Glu 330 335 340 ttc cgc atc aac ggc gaa gac gct ggc tcc aac ttc atg cct gca cca 1171 Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn Phe Met Pro Ala Pro 345 350 355 ggc aag atc acc agc tac cgc gag cca cag ggc cca ggc gtc cgc atg 1219 Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly Pro Gly Val Arg Met 360 365 370 gac tcc ggt gtc gtt gaa ggt tcc gaa atc tcc gga cag ttc gac tcc 1267 Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser Gly Gln Phe Asp Ser 375 380 385 atg ctg gca aag ctg atc gtt tgg ggc gac acc cgc gag cag gct ctc 1315 Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr Arg Glu Gln Ala Leu 390 395 400 405 cag cgc tcc cgc cgt gca ctt gca gag tac gtt gtc gag ggc atg cca 1363 Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val Val Glu Gly Met Pro 410 415 420 acc gtt atc cca ttc cac cag cac atc gtg gaa aac cca gca ttc gtg 1411 Thr Val Ile Pro Phe His Gln His Ile Val Glu Asn Pro Ala Phe Val 425 430 435 ggc aac gac gaa ggc ttc gag atc tac acc aag tgg atc gaa gag gtt 1459 Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys Trp Ile Glu Glu Val 440 445 450 tgg gat aac cca atc gca cct tac gtt gac gct tcc gag ctc gac gaa 1507 Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala Ser Glu Leu Asp Glu 455 460 465 gat gag gac aag acc cca gca cag aag gtt gtt gtg gag atc aac ggc 1555 Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val Val Glu Ile Asn Gly 470 475 480 485 cgt cgc gtt gag gtt gca ctc cca ggc gat ctg gca ctc ggt ggc acc 1603 Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu Ala Leu Gly Gly Thr 490 495 500 gct ggt cct aag aag aag gcc aag aag cgt cgc gca ggt ggt gca aag 1651 Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg Ala Gly Gly Ala Lys 505 510 515 gct ggc gta tcc ggc gat gca gtg gca gct cca atg cag ggc act gtc 1699 Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro Met Gln Gly Thr Val 520 525 530 atc aag gtc aac gtc gaa gaa ggc gct gaa gtc aac gaa ggc gac acc 1747 Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val Asn Glu Gly Asp Thr 535 540 545 gtt gtt gtc ctc gag gct atg aag atg gaa aac cct gtg aag gct cat 1795 Val Val Val Leu Glu Ala Met Lys Met Glu Asn Pro Val Lys Ala His 550 555 560 565 aag tcc gga acc gta acc ggc ctt act gtc gct gca ggc gag ggt gtc 1843 Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala Ala Gly Glu Gly Val 570 575 580 aac aag ggc gtt gtt ctc ctc gag atc aag taagttcttg gattcctgtt 1893 Asn Lys Gly Val Val Leu Leu Glu Ile Lys 585 590 agtcaaaaac 1903 <210> 132 <211> 591 <212> PRT <213> Corynebacterium glutamicum <400> 132 Val Ser Val Glu Thr Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg 1 5 10 15 Gly Glu Ile Ala Ile Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Ile 20 25 30 Gly Ser Val Ala Val Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val 35 40 45 Ser Tyr Ala Asp Glu Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu 50 55 60 Ser Tyr Leu Val Ile Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly 65 70 75 80 Ala Asp Ala Ile His Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp 85 90 95 Phe Ala Glu Ala Val Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser 100 105 110 Pro Glu Ser Ile Arg Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile 115 120 125 Ala Asp Thr Ala Lys Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val 130 135 140 Lys Asp Ala Ala Glu Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro 145 150 155 160 Ile Ala Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val 165 170 175 Ala Tyr Lys Met Glu Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg 180 185 190 Glu Ala Thr Ala Ala Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr 195 200 205 Leu Asp Lys Ala Arg His Val Glu Ala Gln Val Ile Ala Asp Lys His 210 215 220 Gly Asn Val Val Val Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg 225 230 235 240 Phe Gln Lys Leu Val Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp 245 250 255 Gln Arg Glu Arg Leu His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala 260 265 270 Gly Tyr Tyr Gly Ala Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly 275 280 285 Leu Ile Ser Phe Leu Glu Val Asn Thr Arg Leu Gln Val Glu His Pro 290 295 300 Val Thr Glu Glu Thr Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg 305 310 315 320 Ile Ala Glu Gly His Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg 325 330 335 Gly His Ala Phe Glu Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn 340 345 350 Phe Met Pro Ala Pro Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly 355 360 365 Pro Gly Val Arg Met Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser 370 375 380 Gly Gln Phe Asp Ser Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr 385 390 395 400 Arg Glu Gln Ala Leu Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val 405 410 415 Val Glu Gly Met Pro Thr Val Ile Pro Phe His Gln His Ile Val Glu 420 425 430 Asn Pro Ala Phe Val Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys 435 440 445 Trp Ile Glu Glu Val Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala 450 455 460 Ser Glu Leu Asp Glu Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val 465 470 475 480 Val Glu Ile Asn Gly Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu 485 490 495 Ala Leu Gly Gly Thr Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg 500 505 510 Ala Gly Gly Ala Lys Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro 515 520 525 Met Gln Gly Thr Val Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val 530 535 540 Asn Glu Gly Asp Thr Val Val Val Leu Glu Ala Met Lys Met Glu Asn 545 550 555 560 Pro Val Lys Ala His Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala 565 570 575 Ala Gly Glu Gly Val Asn Lys Gly Val Val Leu Leu Glu Ile Lys 580 585 590 <210> 133 <211> 1441 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1411) <223> RXA02394 <400> 133 tacccccttg ttgatgaatc agaagaacct cgagatttgg acgagctaga ggcccaaagc 60 gctatagatt ctgcaagttc agcggaaggt aggaactaat atg ttg tcg cca gca 115 Met Leu Ser Pro Ala 1 5 gct gta gca gct tta att ctt gtc atc ggc att gtg gtg ctc atc atc 163 Ala Val Ala Ala Leu Ile Leu Val Ile Gly Ile Val Val Leu Ile Ile 10 15 20 gca tca gtg ccc gtt gcc att gcc atc ggt ttg cca tca ctt ttt gcc 211 Ala Ser Val Pro Val Ala Ile Ala Ile Gly Leu Pro Ser Leu Phe Ala 25 30 35 gcg atg gcc gtg ctt ggc cca gaa aac gcc gcg cag gcc gtc gcg cag 259 Ala Met Ala Val Leu Gly Pro Glu Asn Ala Ala Gln Ala Val Ala Gln 40 45 50 cgc atg ttt acc ggc aca aac tcc ttt aca ctc ctt gcc att ccg ttc 307 Arg Met Phe Thr Gly Thr Asn Ser Phe Thr Leu Leu Ala Ile Pro Phe 55 60 65 ttc gtg ttg gcg ggt ttg ctg atg aac tcg ggt ggt att gcc acg cgg 355 Phe Val Leu Ala Gly Leu Leu Met Asn Ser Gly Gly Ile Ala Thr Arg 70 75 80 85 ctt atc gac gcc gcg aag gtg ctt gtc ggc cgc atg cct gcc tcc atg 403 Leu Ile Asp Ala Ala Lys Val Leu Val Gly Arg Met Pro Ala Ser Met 90 95 100 gcc aat acg aat atc gca gca aat ggt ctc ttc gga gca gtt tca ggg 451 Ala Asn Thr Asn Ile Ala Ala Asn Gly Leu Phe Gly Ala Val Ser Gly 105 110 115 gca gcg gta gca tca gct tct gcc gtg gga acc gtc atg aca cca aaa 499 Ala Ala Val Ala Ser Ala Ser Ala Val Gly Thr Val Met Thr Pro Lys 120 125 130 atg aag gaa gag ggc tac tcg cgc gct tac gca gcg gcc gtc aac gtg 547 Met Lys Glu Glu Gly Tyr Ser Arg Ala Tyr Ala Ala Ala Val Asn Val 135 140 145 gct tca gca cct gcg ggc atg ctg atc ccg cca tca aac act ttt att 595 Ala Ser Ala Pro Ala Gly Met Leu Ile Pro Pro Ser Asn Thr Phe Ile 150 155 160 165 gtg tat tcc ttg gtg tcc tcg aca tca att gca gca cta ttt atg gcc 643 Val Tyr Ser Leu Val Ser Ser Thr Ser Ile Ala Ala Leu Phe Met Ala 170 175 180 ggt gtt gga ccc ggt ctg ctc tgg att ctg gcc tgt gtc atc gtg gga 691 Gly Val Gly Pro Gly Leu Leu Trp Ile Leu Ala Cys Val Ile Val Gly 185 190 195 act tgg tta gcg cga aag gaa aac tac aag cgc gag cag att cat cca 739 Thr Trp Leu Ala Arg Lys Glu Asn Tyr Lys Arg Glu Gln Ile His Pro 200 205 210 aca ttc aag cag tcg ctc gtt gtg ctg tgg agg gcg ctg cct tca ctg 787 Thr Phe Lys Gln Ser Leu Val Val Leu Trp Arg Ala Leu Pro Ser Leu 215 220 225 ctc atg atc gtc att gtt gtt gga ggt atc ttg ctg ggc tgg ttc act 835 Leu Met Ile Val Ile Val Val Gly Gly Ile Leu Leu Gly Trp Phe Thr 230 235 240 245 cca act gaa tcc gct gct att gct gta gtg tac tgc ctg gtc ttg ggc 883 Pro Thr Glu Ser Ala Ala Ile Ala Val Val Tyr Cys Leu Val Leu Gly 250 255 260 ttt att tac cgc aca atc aag gtg gga gat ctg gca gat att ttg ctc 931 Phe Ile Tyr Arg Thr Ile Lys Val Gly Asp Leu Ala Asp Ile Leu Leu 265 270 275 aag gca act cgc acc aca tca att gtc atg ttg ctc att gca gtt tct 979 Lys Ala Thr Arg Thr Thr Ser Ile Val Met Leu Leu Ile Ala Val Ser 280 285 290 gca gca ctg tcg tgg gtg atg gcc ttt gcc aag atc cct cag atg atc 1027 Ala Ala Leu Ser Trp Val Met Ala Phe Ala Lys Ile Pro Gln Met Ile 295 300 305 tct gat gcg ctt ctt tcg gta tcc gat tcc aag gtt gtc atc ttg ttg 1075 Ser Asp Ala Leu Leu Ser Val Ser Asp Ser Lys Val Val Ile Leu Leu 310 315 320 325 atc atg atg ttc atc ctg tta ctc atc ggt acc gta atg gac cca aca 1123 Ile Met Met Phe Ile Leu Leu Leu Ile Gly Thr Val Met Asp Pro Thr 330 335 340 cca gca att ttg atc ttc gtc ccg atc ttc ctt cca gtg gtt acc gaa 1171 Pro Ala Ile Leu Ile Phe Val Pro Ile Phe Leu Pro Val Val Thr Glu 345 350 355 ctt ggt gtg gac cca gtc cac ttc ggt gcg atg gtg gta atg aac ctg 1219 Leu Gly Val Asp Pro Val His Phe Gly Ala Met Val Val Met Asn Leu 360 365 370 tcc gtg ggc gtg att acc cca cca gta ggc aac gtg ttg ttc gtt ggt 1267 Ser Val Gly Val Ile Thr Pro Pro Val Gly Asn Val Leu Phe Val Gly 375 380 385 tcg caa gtg gca ggg ctg cgt gtg gaa act gtg atc aga cga ctg tgg 1315 Ser Gln Val Ala Gly Leu Arg Val Glu Thr Val Ile Arg Arg Leu Trp 390 395 400 405 ccg tat ctc att gcc att att gtt gcg ctg ttc gtg gtt gtt ttc gta 1363 Pro Tyr Leu Ile Ala Ile Ile Val Ala Leu Phe Val Val Val Phe Val 410 415 420 ccg cag atc tct atc tgg ctg ccc aca aca atg gga ttg atg gga ggc 1411 Pro Gln Ile Ser Ile Trp Leu Pro Thr Thr Met Gly Leu Met Gly Gly 425 430 435 taaacctcca gccatcagct aagaaaccgc 1441 <210> 134 <211> 437 <212> PRT <213> Corynebacterium glutamicum <400> 134 Met Leu Ser Pro Ala Ala Val Ala Ala Leu Ile Leu Val Ile Gly Ile 1 5 10 15 Val Val Leu Ile Ile Ala Ser Val Pro Val Ala Ile Ala Ile Gly Leu 20 25 30 Pro Ser Leu Phe Ala Ala Met Ala Val Leu Gly Pro Glu Asn Ala Ala 35 40 45 Gln Ala Val Ala Gln Arg Met Phe Thr Gly Thr Asn Ser Phe Thr Leu 50 55 60 Leu Ala Ile Pro Phe Phe Val Leu Ala Gly Leu Leu Met Asn Ser Gly 65 70 75 80 Gly Ile Ala Thr Arg Leu Ile Asp Ala Ala Lys Val Leu Val Gly Arg 85 90 95 Met Pro Ala Ser Met Ala Asn Thr Asn Ile Ala Ala Asn Gly Leu Phe 100 105 110 Gly Ala Val Ser Gly Ala Ala Val Ala Ser Ala Ser Ala Val Gly Thr 115 120 125 Val Met Thr Pro Lys Met Lys Glu Glu Gly Tyr Ser Arg Ala Tyr Ala 130 135 140 Ala Ala Val Asn Val Ala Ser Ala Pro Ala Gly Met Leu Ile Pro Pro 145 150 155 160 Ser Asn Thr Phe Ile Val Tyr Ser Leu Val Ser Ser Thr Ser Ile Ala 165 170 175 Ala Leu Phe Met Ala Gly Val Gly Pro Gly Leu Leu Trp Ile Leu Ala 180 185 190 Cys Val Ile Val Gly Thr Trp Leu Ala Arg Lys Glu Asn Tyr Lys Arg 195 200 205 Glu Gln Ile His Pro Thr Phe Lys Gln Ser Leu Val Val Leu Trp Arg 210 215 220 Ala Leu Pro Ser Leu Leu Met Ile Val Ile Val Val Gly Gly Ile Leu 225 230 235 240 Leu Gly Trp Phe Thr Pro Thr Glu Ser Ala Ala Ile Ala Val Val Tyr 245 250 255 Cys Leu Val Leu Gly Phe Ile Tyr Arg Thr Ile Lys Val Gly Asp Leu 260 265 270 Ala Asp Ile Leu Leu Lys Ala Thr Arg Thr Thr Ser Ile Val Met Leu 275 280 285 Leu Ile Ala Val Ser Ala Ala Leu Ser Trp Val Met Ala Phe Ala Lys 290 295 300 Ile Pro Gln Met Ile Ser Asp Ala Leu Leu Ser Val Ser Asp Ser Lys 305 310 315 320 Val Val Ile Leu Leu Ile Met Met Phe Ile Leu Leu Leu Ile Gly Thr 325 330 335 Val Met Asp Pro Thr Pro Ala Ile Leu Ile Phe Val Pro Ile Phe Leu 340 345 350 Pro Val Val Thr Glu Leu Gly Val Asp Pro Val His Phe Gly Ala Met 355 360 365 Val Val Met Asn Leu Ser Val Gly Val Ile Thr Pro Pro Val Gly Asn 370 375 380 Val Leu Phe Val Gly Ser Gln Val Ala Gly Leu Arg Val Glu Thr Val 385 390 395 400 Ile Arg Arg Leu Trp Pro Tyr Leu Ile Ala Ile Ile Val Ala Leu Phe 405 410 415 Val Val Val Phe Val Pro Gln Ile Ser Ile Trp Leu Pro Thr Thr Met 420 425 430 Gly Leu Met Gly Gly 435 <210> 135 <211> 2035 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2005) <223> RXA02395 <400> 135 ttgcttataa tacaaaaaca ggaatattta actcgacttc ttaaaaaagc tctatacgta 60 aatatcttgc ccatccagca ccacctcatt gtggtgcaca atg gag agg aca cac 115 Met Glu Arg Thr His 1 5 atg tcc acc aac tct ggc aat aac ttg cct gaa tcc caa gag tca ccc 163 Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro 10 15 20 gag gaa cct cat tat cct cac gac acc cac cca ggc cta gtt cct ggc 211 Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly 25 30 35 att tcg gtc gat gct caa cgc aac aag ttc gga ctc gac aaa acc gtt 259 Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val 40 45 50 ttc ggc gtc acc gca gca tta att ctg gcg ttc atc gcc tgg ggc att 307 Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile 55 60 65 tcc agc cct gat tcg gtt tct tca gta tcg tcc acg atg ttc agt tgg 355 Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp 70 75 80 85 gct atg acg aat act ggt tgg ctc ctc aac ttt gtc atg ctg atc ggc 403 Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly 90 95 100 att ggc acc atg ctc tac atc gct ttt tcg cgc tac ggc cgc atc aag 451 Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys 105 110 115 ctg ggc acg gac gaa gac gaa cca gaa ttc tct cgc ttt tcc tgg att 499 Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile 120 125 130 gcg atg atg ttc ggc gcc ggc atc ggt gtc ggt atc ttc ttc ttc ggt 547 Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly 135 140 145 cct tcc gaa ccg ctg tgg cat tat ctc agt ccc cca cct cac acc gtg 595 Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val 150 155 160 165 gaa gga tct aca cct gag tcc ttg cac caa gca ctt gcg cag tcc cac 643 Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His 170 175 180 ttc cac tgg ggc tta tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc 691 Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly 185 190 195 gcg ttg gcg tac tcc agt tac cga cgc ggc cgc gta acc ttg atc agc 739 Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser 200 205 210 tcc acc ttc cgg tca ctt ttc ggt gag aaa acc gaa ggt atc gcg ggt 787 Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly 215 220 225 cgc ctc atc gac atg atg gcg atc atc gcc acg ctg ttt gga acg gct 835 Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala 230 235 240 245 gca acc ttg ggc ctt tca gca att cag gtt ggt cag ggc gtg cag att 883 Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile 250 255 260 att tct ggc gct tcg gaa atc acc aac aac atc ttg atc gcc atc atc 931 Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile 265 270 275 gcg atc ttg acc att ggc ttc atc atc tcc tca gta tct ggc gtg tcc 979 Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser 280 285 290 aag ggc att cgt tat ctt tcc aac ctc aat att tcc ttg acg ctt gga 1027 Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly 295 300 305 ttg gtc ctg ttt gtg ttc atc acc ggc ccc acc ttg ttc ctg ctc aac 1075 Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn 310 315 320 325 ttg atc cca tcg agt gtg ttg gaa tat ggc agt gag ttc ttg tca atg 1123 Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met 330 335 340 gct ggc aag tct ttg tcg tgg ggt gag gaa acc att gaa ttc caa gct 1171 Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala 345 350 355 ggt tgg acg gcg ttc tac tgg gca tgg tgg atc gca tgg act cca ttc 1219 Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe 360 365 370 gtg ggt atg ttc atc gcg cgt att tct cgc ggc cgc acc ttg cgt gaa 1267 Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu 375 380 385 ttc gcg ctc atc acc atg gct atc ccc tcc ttc att ttg atc ctg gcg 1315 Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala 390 395 400 405 ttc acc att ttc ggt gga act gcc atc acg atg aac cgc gag aac gta 1363 Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val 410 415 420 gat ggt ttt gac ggc agt tca tcc aag gaa cag gtg ctg ttt gat atg 1411 Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met 425 430 435 ttc agc aac ctt ccg ctg tac tcg atc aca ccg ttc att ttg atc ttt 1459 Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe 440 445 450 gtg ctg gca gta ttc ttt gtt acc tct gcc gat tcc gcc tcc gtg gtg 1507 Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val 455 460 465 atg gga acg atg agc tcc caa ggt aac cct gca cca aac aaa tta atc 1555 Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile 470 475 480 485 gtg gtg ttc tgg gga ctg tgc atg atg ggc atc gcg gtg gtc atg ctg 1603 Val Val Phe Trp Gly Leu Cys Met Met Gly Ile Ala Val Val Met Leu 490 495 500 ctt act ggt ggc gaa tcc gcg ctg act ggt ctg cag aac ctc acc att 1651 Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile 505 510 515 ttg atc gcc att ccg ttt gcg ctg gtg ttg atc gtg atg gct att gcc 1699 Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala 520 525 530 ttt att aag gac tta tcc aca gac cca gcc gct att cga caa cgc tat 1747 Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr 535 540 545 gca aag gca gcc atc tct aac gcg gtg gtt cgt ggc ttg gaa gaa cac 1795 Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg Gly Leu Glu Glu His 550 555 560 565 ggc gac gac ttc gag ctc tcc atc gaa cct gca gag gaa ggt cgt gga 1843 Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly 570 575 580 gcg ggt gct acc ttc gat tcc acc gct gat cac atc acc gac tgg tat 1891 Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr 585 590 595 cag cgc acc gac gaa gaa ggc aat gat gtt gat tat gac ttc acc acc 1939 Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr 600 605 610 ggc aaa tgg gcc gat ggt tgg aca ccg gaa tcg acc gaa gaa ggc gaa 1987 Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu 615 620 625 gtg gac gcg aaa aag gat taaaaaataa cgactggctg ggattcacac 2035 Val Asp Ala Lys Lys Asp 630 635 <210> 136 <211> 635 <212> PRT <213> Corynebacterium glutamicum <400> 136 Met Glu Arg Thr His Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu 1 5 10 15 Ser Gln Glu Ser Pro Glu Glu Pro His Tyr Pro His Asp Thr His Pro 20 25 30 Gly Leu Val Pro Gly Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly 35 40 45 Leu Asp Lys Thr Val Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe 50 55 60 Ile Ala Trp Gly Ile Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser 65 70 75 80 Thr Met Phe Ser Trp Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe 85 90 95 Val Met Leu Ile Gly Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg 100 105 110 Tyr Gly Arg Ile Lys Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser 115 120 125 Arg Phe Ser Trp Ile Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly 130 135 140 Ile Phe Phe Phe Gly Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro 145 150 155 160 Pro Pro His Thr Val Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala 165 170 175 Leu Ala Gln Ser His Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr 180 185 190 Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg 195 200 205 Val Thr Leu Ile Ser Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr 210 215 220 Glu Gly Ile Ala Gly Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr 225 230 235 240 Leu Phe Gly Thr Ala Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly 245 250 255 Gln Gly Val Gln Ile Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile 260 265 270 Leu Ile Ala Ile Ile Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser 275 280 285 Val Ser Gly Val Ser Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile 290 295 300 Ser Leu Thr Leu Gly Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr 305 310 315 320 Leu Phe Leu Leu Asn Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser 325 330 335 Glu Phe Leu Ser Met Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr 340 345 350 Ile Glu Phe Gln Ala Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile 355 360 365 Ala Trp Thr Pro Phe Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly 370 375 380 Arg Thr Leu Arg Glu Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe 385 390 395 400 Ile Leu Ile Leu Ala Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met 405 410 415 Asn Arg Glu Asn Val Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln 420 425 430 Val Leu Phe Asp Met Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro 435 440 445 Phe Ile Leu Ile Phe Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp 450 455 460 Ser Ala Ser Val Val Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala 465 470 475 480 Pro Asn Lys Leu Ile Val Val Phe Trp Gly Leu Cys Met Met Gly Ile 485 490 495 Ala Val Val Met Leu Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu 500 505 510 Gln Asn Leu Thr Ile Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile 515 520 525 Val Met Ala Ile Ala Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala 530 535 540 Ile Arg Gln Arg Tyr Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg 545 550 555 560 Gly Leu Glu Glu His Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala 565 570 575 Glu Glu Gly Arg Gly Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His 580 585 590 Ile Thr Asp Trp Tyr Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp 595 600 605 Tyr Asp Phe Thr Thr Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser 610 615 620 Thr Glu Glu Gly Glu Val Asp Ala Lys Lys Asp 625 630 635 <210> 137 <211> 1627 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1597) <223> RXA02426 <400> 137 actgaaaaac tgacaaacct gacagacctg acccgaagag accttattca tgacgatatt 60 gttcatgctc attacattgc tgctcgccac cgtgattgtg gtg gcc atc ggc gat 115 Val Ala Ile Gly Asp 1 5 aaa acc gga ctc ccc tgg cct gct ttg atg act att gtc gcc gca ggt 163 Lys Thr Gly Leu Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala Gly 10 15 20 gga gcg ttg ttg cca ttt ttg ccg gaa ttt act atc ccg gcc gat ctg 211 Gly Ala Leu Leu Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp Leu 25 30 35 atg ttg cct att ttc att ccg ccg ctg ctg tgg gcg ctg gcg agg aag 259 Met Leu Pro Ile Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg Lys 40 45 50 tca tcg tgg gcg gtg att agg tcg cag atg tct acc atc atc acg atg 307 Ser Ser Trp Ala Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr Met 55 60 65 tcg gtg ttg ttg gtg ttc gtg acc atc gcg gca ctc acg ggt gca tcc 355 Ser Val Leu Leu Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala Ser 70 75 80 85 atg ctg ttg ctt cct ggc att ggt ctt gct ggt gcg atc atg ttg gct 403 Met Leu Leu Leu Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu Ala 90 95 100 gcg gct att gct cca ccg gat cct gtt gct gtt gat gca gtg gcg gaa 451 Ala Ala Ile Ala Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala Glu 105 110 115 cct gcg gga atc ccg aag cgc atc acc acc act ttg cag acg gag ggt 499 Pro Ala Gly Ile Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu Gly 120 125 130 ctg ttt aat gat gca gcc agc atc gtg gcg ttc cat gtg gct tta gct 547 Leu Phe Asn Asp Ala Ala Ser Ile Val Ala Phe His Val Ala Leu Ala 135 140 145 gcc ctg gtc gct ggt gag gat ttg tcc tgg tca acg ggt gtt ttg gaa 595 Ala Leu Val Ala Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu Glu 150 155 160 165 ttc ttg tgg tcg tgt ctt gct gcc gtt att ttg ggc ttg gtt att ggc 643 Phe Leu Trp Ser Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile Gly 170 175 180 cgg gcg gct gcg tgg ttt acc gat cac gtg agt tcc gtt gag gct cga 691 Arg Ala Ala Ala Trp Phe Thr Asp His Val Ser Ser Val Glu Ala Arg 185 190 195 aat gcg ttt acg tgg gtg ctg ccg ttt gcc att tat gtg gtg gcg gaa 739 Asn Ala Phe Thr Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala Glu 200 205 210 gaa atc ggc ggt tcg ggc gtt atc gcc att gtg atc gct gca gtg gag 787 Glu Ile Gly Gly Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val Glu 215 220 225 atg aat tcg agg gcg tcg att ggt gcg gag gat cgt cta acg ggt tct 835 Met Asn Ser Arg Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly Ser 230 235 240 245 gcg ttc tgg gga acc att gag gtg ctg ttt act ggc gtt gcc ttt ggt 883 Ala Phe Trp Gly Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe Gly 250 255 260 ttg atc ggc ctg aat gtg cgc gct gcg att gat gaa gtt gga tct gag 931 Leu Ile Gly Leu Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser Glu 265 270 275 ctg tgg cat gcc gtg gtc gtg ggc att gtg ctc tcg gtg gtg gcg atc 979 Leu Trp His Ala Val Val Val Gly Ile Val Leu Ser Val Val Ala Ile 280 285 290 gtt gtc cgt ggt gtg tgg atg ttc gcg gcg tat aag cgc aat cgt ttc 1027 Val Val Arg Gly Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg Phe 295 300 305 aag atc gat aag aag ggt gcg acc aat agt tca ttg cgg gcg cct ctt 1075 Lys Ile Asp Lys Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro Leu 310 315 320 325 cga ctg cag gaa tcg ttg ctg atg acg tgg gcg ggc atg cgc ggt ttg 1123 Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly Leu 330 335 340 gtg acg ttg gcg ctg gtg ctg tct att ccg gag gat att ttc ccg tat 1171 Val Thr Leu Ala Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro Tyr 345 350 355 cac cac gag ttg cag gtc att gcg ctg gtc gtt ctc tta atc acc atg 1219 His His Glu Leu Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr Met 360 365 370 gtg ggc cct ggt ttg acg ttg ccg tgg ctg atg cgg aag ctc agc ttg 1267 Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser Leu 375 380 385 gat aag ggt ccc gat gct gcg ggc gat gag agt atc gcc gcg ctg aca 1315 Asp Lys Gly Pro Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu Thr 390 395 400 405 gag agg gct cac aag gcc gca aca acg tat ttg gtg gat acc acg gag 1363 Glu Arg Ala His Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr Glu 410 415 420 ttg ccg atg gag cag atg gtg gcg atc aag aat tgg ttc tcg caa gaa 1411 Leu Pro Met Glu Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln Glu 425 430 435 att gac gct gat gaa ctg cag gag aac gtc gat aag ctg cat cag cgc 1459 Ile Asp Ala Asp Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln Arg 440 445 450 gcg cat cat gcg cgt gtc ggg gca att aag gcg gcc cag gag gag ctg 1507 Ala His His Ala Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu Leu 455 460 465 ttg aag gcg cgg cgg gag cgc ggc gtt aat ccg gcc tat gtt gat gag 1555 Leu Lys Ala Arg Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp Glu 470 475 480 485 gtg ttg acc aac att gac cgg atg ctt gtt gcg gct gaa cgc 1597 Val Leu Thr Asn Ile Asp Arg Met Leu Val Ala Ala Glu Arg 490 495 tagataaaca gcagcaggct gatcgccatg 1627 <210> 138 <211> 499 <212> PRT <213> Corynebacterium glutamicum <400> 138 Val Ala Ile Gly Asp Lys Thr Gly Leu Pro Trp Pro Ala Leu Met Thr 1 5 10 15 Ile Val Ala Ala Gly Gly Ala Leu Leu Pro Phe Leu Pro Glu Phe Thr 20 25 30 Ile Pro Ala Asp Leu Met Leu Pro Ile Phe Ile Pro Pro Leu Leu Trp 35 40 45 Ala Leu Ala Arg Lys Ser Ser Trp Ala Val Ile Arg Ser Gln Met Ser 50 55 60 Thr Ile Ile Thr Met Ser Val Leu Leu Val Phe Val Thr Ile Ala Ala 65 70 75 80 Leu Thr Gly Ala Ser Met Leu Leu Leu Pro Gly Ile Gly Leu Ala Gly 85 90 95 Ala Ile Met Leu Ala Ala Ala Ile Ala Pro Pro Asp Pro Val Ala Val 100 105 110 Asp Ala Val Ala Glu Pro Ala Gly Ile Pro Lys Arg Ile Thr Thr Thr 115 120 125 Leu Gln Thr Glu Gly Leu Phe Asn Asp Ala Ala Ser Ile Val Ala Phe 130 135 140 His Val Ala Leu Ala Ala Leu Val Ala Gly Glu Asp Leu Ser Trp Ser 145 150 155 160 Thr Gly Val Leu Glu Phe Leu Trp Ser Cys Leu Ala Ala Val Ile Leu 165 170 175 Gly Leu Val Ile Gly Arg Ala Ala Ala Trp Phe Thr Asp His Val Ser 180 185 190 Ser Val Glu Ala Arg Asn Ala Phe Thr Trp Val Leu Pro Phe Ala Ile 195 200 205 Tyr Val Val Ala Glu Glu Ile Gly Gly Ser Gly Val Ile Ala Ile Val 210 215 220 Ile Ala Ala Val Glu Met Asn Ser Arg Ala Ser Ile Gly Ala Glu Asp 225 230 235 240 Arg Leu Thr Gly Ser Ala Phe Trp Gly Thr Ile Glu Val Leu Phe Thr 245 250 255 Gly Val Ala Phe Gly Leu Ile Gly Leu Asn Val Arg Ala Ala Ile Asp 260 265 270 Glu Val Gly Ser Glu Leu Trp His Ala Val Val Val Gly Ile Val Leu 275 280 285 Ser Val Val Ala Ile Val Val Arg Gly Val Trp Met Phe Ala Ala Tyr 290 295 300 Lys Arg Asn Arg Phe Lys Ile Asp Lys Lys Gly Ala Thr Asn Ser Ser 305 310 315 320 Leu Arg Ala Pro Leu Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Ala 325 330 335 Gly Met Arg Gly Leu Val Thr Leu Ala Leu Val Leu Ser Ile Pro Glu 340 345 350 Asp Ile Phe Pro Tyr His His Glu Leu Gln Val Ile Ala Leu Val Val 355 360 365 Leu Leu Ile Thr Met Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met 370 375 380 Arg Lys Leu Ser Leu Asp Lys Gly Pro Asp Ala Ala Gly Asp Glu Ser 385 390 395 400 Ile Ala Ala Leu Thr Glu Arg Ala His Lys Ala Ala Thr Thr Tyr Leu 405 410 415 Val Asp Thr Thr Glu Leu Pro Met Glu Gln Met Val Ala Ile Lys Asn 420 425 430 Trp Phe Ser Gln Glu Ile Asp Ala Asp Glu Leu Gln Glu Asn Val Asp 435 440 445 Lys Leu His Gln Arg Ala His His Ala Arg Val Gly Ala Ile Lys Ala 450 455 460 Ala Gln Glu Glu Leu Leu Lys Ala Arg Arg Glu Arg Gly Val Asn Pro 465 470 475 480 Ala Tyr Val Asp Glu Val Leu Thr Asn Ile Asp Arg Met Leu Val Ala 485 490 495 Ala Glu Arg <210> 139 <211> 1654 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1624) <223> RXA02447 <400> 139 ttaaatgctc cgaaccattt tccataagtc tgctatgtgg atcggttaag aactgcagat 60 agcagcaatt gtgacttcat caaagatata aggacgcgac atg acg gac atc aag 115 Met Thr Asp Ile Lys 1 5 tcc aca tca agt aca tcg gcc gct aca gca cca aca gca ggc cgg cca 163 Ser Thr Ser Ser Thr Ser Ala Ala Thr Ala Pro Thr Ala Gly Arg Pro 10 15 20 gcg cgt cga ctt ggt caa att tcc ctc gtc gcc tgt ctc gac gga ctt 211 Ala Arg Arg Leu Gly Gln Ile Ser Leu Val Ala Cys Leu Asp Gly Leu 25 30 35 ctc ttc ggc tat gac acc ggt gtc gcc agc ggc gcc gaa ggc cac atg 259 Leu Phe Gly Tyr Asp Thr Gly Val Ala Ser Gly Ala Glu Gly His Met 40 45 50 gca caa gaa ctc gga ctc aac gtg ctg cag ctc ggc gtt gtc atc agt 307 Ala Gln Glu Leu Gly Leu Asn Val Leu Gln Leu Gly Val Val Ile Ser 55 60 65 tca ctg gtt ttc gct gca gcc ttt ggc gcg ctg ttc gct ggg cgt atc 355 Ser Leu Val Phe Ala Ala Ala Phe Gly Ala Leu Phe Ala Gly Arg Ile 70 75 80 85 tcg gac gaa atc ggg cgt cga aaa gca att atc act ttg tcc gtg ctg 403 Ser Asp Glu Ile Gly Arg Arg Lys Ala Ile Ile Thr Leu Ser Val Leu 90 95 100 ttc ttc ctc gga tca atc ctc gtc gta ttc tcc ccc gcc ggt gag ctg 451 Phe Phe Leu Gly Ser Ile Leu Val Val Phe Ser Pro Ala Gly Glu Leu 105 110 115 ggg cag ttc tac gga cca gga ttt gcc acc ttg gtc acc ggg cgc atc 499 Gly Gln Phe Tyr Gly Pro Gly Phe Ala Thr Leu Val Thr Gly Arg Ile 120 125 130 atg ttg ggt ctc gcg gtt ggc ggc gcc tcc aca gta gtt ccg gtg tac 547 Met Leu Gly Leu Ala Val Gly Gly Ala Ser Thr Val Val Pro Val Tyr 135 140 145 ctc gct gaa ctc gca cca cta gaa atc cgc ggc tcc ctg acc ggc cga 595 Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg Gly Ser Leu Thr Gly Arg 150 155 160 165 aac gag ctt gct atc gtc acc ggc cag ctg ctt gcc ttc gtg atc aac 643 Asn Glu Leu Ala Ile Val Thr Gly Gln Leu Leu Ala Phe Val Ile Asn 170 175 180 gcg ctt atc gcc gtc acc cta cac gga gtt att gat gga atc tgg cgc 691 Ala Leu Ile Ala Val Thr Leu His Gly Val Ile Asp Gly Ile Trp Arg 185 190 195 atc atg ttc gcc gtc tgt gcc ctc cct gcc gtc gcc ctc ttc ctc ggc 739 Ile Met Phe Ala Val Cys Ala Leu Pro Ala Val Ala Leu Phe Leu Gly 200 205 210 atg ctg cgg atg ccg gaa tca cca cgc tgg ctg gtc aac cag ggg cgt 787 Met Leu Arg Met Pro Glu Ser Pro Arg Trp Leu Val Asn Gln Gly Arg 215 220 225 tac gac gac gcc cgc cgc gtc atg gag acc gtc cgt acc cct gag cgt 835 Tyr Asp Asp Ala Arg Arg Val Met Glu Thr Val Arg Thr Pro Glu Arg 230 235 240 245 gcg aaa gcc gaa atg gat gaa atc atc gcg gtg cac tct gaa aac aat 883 Ala Lys Ala Glu Met Asp Glu Ile Ile Ala Val His Ser Glu Asn Asn 250 255 260 gcg gca ctt cct ggt gtt aag cag tct tcg ggc cag gct tca ggc cag 931 Ala Ala Leu Pro Gly Val Lys Gln Ser Ser Gly Gln Ala Ser Gly Gln 265 270 275 gtt tct agc aag cac acc cac atg tcc atc ggc gaa gtc ctc agc aac 979 Val Ser Ser Lys His Thr His Met Ser Ile Gly Glu Val Leu Ser Asn 280 285 290 aaa tgg ctg gtt cgt ctg ctc atc gcc ggc atc ggt gtt gca gtt gcc 1027 Lys Trp Leu Val Arg Leu Leu Ile Ala Gly Ile Gly Val Ala Val Ala 295 300 305 cag cag ctc acc ggc atc aac gcc atc atg tac tac gga acc cgc gtc 1075 Gln Gln Leu Thr Gly Ile Asn Ala Ile Met Tyr Tyr Gly Thr Arg Val 310 315 320 325 ctc gag gaa tcc ggc atg agc gca gaa atg gct gtg gtt gcc aac att 1123 Leu Glu Glu Ser Gly Met Ser Ala Glu Met Ala Val Val Ala Asn Ile 330 335 340 gct ttc ggt gcc gtt gcc gtc atc ggt gga ctg atc gca ctg cgc aac 1171 Ala Phe Gly Ala Val Ala Val Ile Gly Gly Leu Ile Ala Leu Arg Asn 345 350 355 atg gac cgc ctg gat cgc cgc acc acc ttc atc atc ggc ctg tca ctg 1219 Met Asp Arg Leu Asp Arg Arg Thr Thr Phe Ile Ile Gly Leu Ser Leu 360 365 370 acc acc acc ttc cac ctt ttg atc gca gct gcc ggc act ctc ctt cca 1267 Thr Thr Thr Phe His Leu Leu Ile Ala Ala Ala Gly Thr Leu Leu Pro 375 380 385 gaa ggt aac tcc att cga cca ttc gcc atc atg atc ctt gtt gtt ggg 1315 Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile Met Ile Leu Val Val Gly 390 395 400 405 ttc gtg ctc tcc atg cag act ttc ctc aac gtt gca gtg tgg gtg tgg 1363 Phe Val Leu Ser Met Gln Thr Phe Leu Asn Val Ala Val Trp Val Trp 410 415 420 ctg gcg gaa atc ttc cca gtc cga atg aag ggt atc ggc acc ggt att 1411 Leu Ala Glu Ile Phe Pro Val Arg Met Lys Gly Ile Gly Thr Gly Ile 425 430 435 tcg gta ttc tgc ggt tgg ggc atc aat ggc gtc cta gcg ttg ttc ttc 1459 Ser Val Phe Cys Gly Trp Gly Ile Asn Gly Val Leu Ala Leu Phe Phe 440 445 450 cca gca ctg gtc tcc ggc gtg ggt atc acc ttc tcc ttc ctt atc ttc 1507 Pro Ala Leu Val Ser Gly Val Gly Ile Thr Phe Ser Phe Leu Ile Phe 455 460 465 gca gtc gtc gga gtc att gcc ctg gcg ttc gtc acc aag ttt gtt cct 1555 Ala Val Val Gly Val Ile Ala Leu Ala Phe Val Thr Lys Phe Val Pro 470 475 480 485 gaa acc cgt ggc cgc tca ctt gaa gaa ctc gat cac gca gca ttc acc 1603 Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu Asp His Ala Ala Phe Thr 490 495 500 ggc cag atc ttc aag aag gct taaaccccct ccgatctctt tggctagcac 1654 Gly Gln Ile Phe Lys Lys Ala 505 <210> 140 <211> 508 <212> PRT <213> Corynebacterium glutamicum <400> 140 Met Thr Asp Ile Lys Ser Thr Ser Ser Thr Ser Ala Ala Thr Ala Pro 1 5 10 15 Thr Ala Gly Arg Pro Ala Arg Arg Leu Gly Gln Ile Ser Leu Val Ala 20 25 30 Cys Leu Asp Gly Leu Leu Phe Gly Tyr Asp Thr Gly Val Ala Ser Gly 35 40 45 Ala Glu Gly His Met Ala Gln Glu Leu Gly Leu Asn Val Leu Gln Leu 50 55 60 Gly Val Val Ile Ser Ser Leu Val Phe Ala Ala Ala Phe Gly Ala Leu 65 70 75 80 Phe Ala Gly Arg Ile Ser Asp Glu Ile Gly Arg Arg Lys Ala Ile Ile 85 90 95 Thr Leu Ser Val Leu Phe Phe Leu Gly Ser Ile Leu Val Val Phe Ser 100 105 110 Pro Ala Gly Glu Leu Gly Gln Phe Tyr Gly Pro Gly Phe Ala Thr Leu 115 120 125 Val Thr Gly Arg Ile Met Leu Gly Leu Ala Val Gly Gly Ala Ser Thr 130 135 140 Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg Gly 145 150 155 160 Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu Leu 165 170 175 Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val Ile 180 185 190 Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala Val 195 200 205 Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp Leu 210 215 220 Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr Val 225 230 235 240 Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala Val 245 250 255 His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser Gly 260 265 270 Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile Gly 275 280 285 Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly Ile 290 295 300 Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met Tyr 305 310 315 320 Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met Ala 325 330 335 Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly Leu 340 345 350 Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe Ile 355 360 365 Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala Ala 370 375 380 Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile Met 385 390 395 400 Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn Val 405 410 415 Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys Gly 420 425 430 Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly Val 435 440 445 Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr Phe 450 455 460 Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe Val 465 470 475 480 Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu Asp 485 490 495 His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala 500 505 <210> 141 <211> 1834 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1804) <223> RXA02487 <400> 141 tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60 atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115 Met Ser Ala Tyr Glu 1 5 acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163 Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu 10 15 20 gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211 Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala 25 30 35 att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259 Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr 40 45 50 tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307 Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg 55 60 65 gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355 Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn 70 75 80 85 tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403 Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala 90 95 100 gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451 Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu 105 110 115 ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499 Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala 120 125 130 tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547 Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile 135 140 145 gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595 Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala 150 155 160 165 ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643 Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser 170 175 180 ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691 Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala 185 190 195 atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739 Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys 200 205 210 gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787 Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro 215 220 225 aag ggt gcc cag ctc acc cac gga aac ctg ttc tcc aat ctc ctc caa 835 Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Ser Asn Leu Leu Gln 230 235 240 245 gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883 Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu 250 255 260 gca gcc cta cca atg ttc cac gca tac ggt ctg acc atg gtc ggc aca 931 Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu Thr Met Val Gly Thr 265 270 275 ctg tcc gtg ttc atc ggt ggc gaa atg gtg cta ctt ccc acc cca cgc 979 Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu Leu Pro Thr Pro Arg 280 285 290 atc gac ctg atc atg aac gta atg aaa aag cac acc cca acc tgg cta 1027 Ile Asp Leu Ile Met Asn Val Met Lys Lys His Thr Pro Thr Trp Leu 295 300 305 cca ggc gtg ccc acc ctt tac gaa aaa atc gtc gac gcc tcc gaa aaa 1075 Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val Asp Ala Ser Glu Lys 310 315 320 325 gaa gga atc ccc atc aag gga gtc cgc aac gcc ttc tcc ggt gca tcc 1123 Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala Phe Ser Gly Ala Ser 330 335 340 aca ctc tcc cag cgc acc gtt gaa cgc tgg gaa aag cac acc ggc gga 1171 Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu Lys His Thr Gly Gly 345 350 355 cgc ctc gtc gaa ggc tac ggc ctc acc gaa acc tcc ccc atc atc gtg 1219 Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr Ser Pro Ile Ile Val 360 365 370 ggt aac ccc atg agc gat cac cga cgc caa ggc tac gta gga atc ccc 1267 Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly Tyr Val Gly Ile Pro 375 380 385 ttc ccc gac acc atc gtg cgc atc gca aac cca gaa aac ctc gac gaa 1315 Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro Glu Asn Leu Asp Glu 390 395 400 405 acc atg ccc gac ggc agc gaa ggc gaa gtc cta gtc aag ggc cca cag 1363 Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu Val Lys Gly Pro Gln 410 415 420 gtg ttc aag ggt tac ctc aac cag gaa gaa gcc acc aag aac agc ttc 1411 Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala Thr Lys Asn Ser Phe 425 430 435 cac ggc gag tgg tac cgc acc ggc gac gtc gga gtg atg gaa gaa gac 1459 His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly Val Met Glu Glu Asp 440 445 450 ggg ttc atc cgc cta gtt gct cgc atc aag gaa gtc atc atc act ggc 1507 Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu Val Ile Ile Thr Gly 455 460 465 ggt ttc aac gtg tac cca gct gag gtt gaa gaa gtc ctc gca gag cac 1555 Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His 470 475 480 485 cca gac att gaa gat tcc gca gtc gtt ggt atc ccg cgt gaa gac ggc 1603 Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly 490 495 500 tcc gaa aac gtc gtt gct gcc atc act ttg gtg gaa ggt gca gcg ctg 1651 Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu 505 510 515 gat ccg gat ggc ctg aag gaa ttc gcc cgc aag aac ctc acc cgc tac 1699 Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr 520 525 530 aag gtt ccg cgc act ttc tac cac ttt gag gag atg ccg cgg gat cag 1747 Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln 535 540 545 atg ggc aag att agg cgt cgt gaa gtg cag gcg gag ttg ttg aag aag 1795 Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys 550 555 560 565 ctc ggc aag tagacgccga tttaagaggt cgagtttccc 1834 Leu Gly Lys <210> 142 <211> 568 <212> PRT <213> Corynebacterium glutamicum <400> 142 Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp 1 5 10 15 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr 20 25 30 Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe 35 40 45 Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr 50 55 60 Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala 65 70 75 80 Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val 85 90 95 Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala 100 105 110 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile 115 120 125 Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr 130 135 140 Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro 145 150 155 160 Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser 165 170 175 Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr 180 185 190 Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu 195 200 205 Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly 210 215 220 Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe 225 230 235 240 Ser Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu 260 265 270 Thr Met Val Gly Thr Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu 275 280 285 Leu Pro Thr Pro Arg Ile Asp Leu Ile Met Asn Val Met Lys Lys His 290 295 300 Thr Pro Thr Trp Leu Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val 305 310 315 320 Asp Ala Ser Glu Lys Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala 325 330 335 Phe Ser Gly Ala Ser Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu 340 345 350 Lys His Thr Gly Gly Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr 355 360 365 Ser Pro Ile Ile Val Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly 370 375 380 Tyr Val Gly Ile Pro Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro 385 390 395 400 Glu Asn Leu Asp Glu Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu 405 410 415 Val Lys Gly Pro Gln Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala 420 425 430 Thr Lys Asn Ser Phe His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly 435 440 445 Val Met Glu Glu Asp Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu 450 455 460 Val Ile Ile Thr Gly Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu 465 470 475 480 Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile 485 490 495 Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val 500 505 510 Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys 515 520 525 Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu 530 535 540 Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala 545 550 555 560 Glu Leu Leu Lys Lys Leu Gly Lys 565 <210> 143 <211> 1093 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1063) <223> RXA02512 <400> 143 gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60 tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115 Met Lys Pro Lys Asp 1 5 ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163 Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr 10 15 20 cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211 Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg 25 30 35 cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259 Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly 40 45 50 atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307 Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn 55 60 65 gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355 Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr 70 75 80 85 tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403 Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu 90 95 100 ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451 Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu 105 110 115 tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499 Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly 120 125 130 aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547 Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe 135 140 145 acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595 Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe 150 155 160 165 gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643 Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly 170 175 180 ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691 Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly 185 190 195 ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val 200 205 210 gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala 215 220 225 cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835 Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val 250 255 260 gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala 265 270 275 aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979 Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp 280 285 290 ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027 Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr 295 300 305 aat gtt cac aaa ccg gtg gca tta cag gag gac aat taggtgcgaa 1073 Asn Val His Lys Pro Val Ala Leu Gln Glu Asp Asn 310 315 320 ttggaatggt ctgcccgtac 1093 <210> 144 <211> 321 <212> PRT <213> Corynebacterium glutamicum <400> 144 Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu 1 5 10 15 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro 20 25 30 Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser 35 40 45 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val 50 55 60 Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg 65 70 75 80 Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala 85 90 95 Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu 100 105 110 Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr 115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser 130 135 140 His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu 180 185 190 Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu 195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met 210 215 220 Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser 245 250 255 Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala 260 265 270 His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met 275 280 285 Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg 290 295 300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu Asp 305 310 315 320 Asn <210> 145 <211> 1339 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1309) <223> RXA02566 <400> 145 gactccggat gatcaagcag cgaaaccttt gtcaagaaca tagctcccca ccctagacaa 60 aagcccaaat aaatctgctc aataacctaa cctaaagtcc atg cac gcc tcg tcg 115 Met His Ala Ser Ser 1 5 ccc caa cct cac cct cag cgc acc cgt gtt ctc agc ggc ctg att ttc 163 Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu Ser Gly Leu Ile Phe 10 15 20 gcc caa atc atg gtt ggt gca tcc aat ggc gtg acg cta tcg atg gga 211 Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly 25 30 35 agt ttg ctg gca gca cac ttg gcg gga gct tcg tgg gga gga tca gcc 259 Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala 40 45 50 gcc aca ttg acc acg atc ggc gca gct atc ttt tcg att ccc ctt gcc 307 Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala 55 60 65 cgc atg gtc tcc aca tac gat cgc cga act tca ctc agc acg ggc atg 355 Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met 70 75 80 85 ttg ctt ggt tgc gtg ggc gca cta ctg gcg atc ctc ggc gca caa ttc 403 Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe 90 95 100 ggc ttg ttt cca gta gta ctt ttg gca ttt ttg ttc ctc gga tcc atg 451 Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met 105 110 115 tcg gcg gtt aac ctc caa gca cgt ttc gcc gca acc gac gtg gcc agt 499 Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser 120 125 130 gaa gaa acc cgc ggc cgc gac ctc tcg atc gtt gtg tgg tcc acc acc 547 Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr 135 140 145 atc ggc gca atc gcc gga cca aat tta ttt gaa cca agc gcc cga ttc 595 Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe 150 155 160 165 agc gaa acc ctg ggc ctc gaa caa cat gcc ggc gca tac ctg ctg tgt 643 Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys 170 175 180 tta ttt ggc cag ctc atc gcc atc gca gtc tgg cga ttc acc ctc ccc 691 Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro 185 190 195 aaa ggc ctc aaa ccc gaa gcc acc cca aat gca cca aca gaa aag aag 739 Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys 200 205 210 cgc ctc acc ccg aaa gcc ctc caa gcc atc aca tcg gtt gca acc gca 787 Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala 215 220 225 cac ttc tcc atg gtc ggt ctc atg tcc atg gcc gcc atc cac atg caa 835 His Phe Ser Met Val Gly Leu Met Ser Met Ala Ala Ile His Met Gln 230 235 240 245 ggc cac ggc gcc agc ctc acc atc atc ggc ttc acc atc agt ttg cac 883 Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe Thr Ile Ser Leu His 250 255 260 gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc ctg ctc aca gac 931 Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly Leu Leu Thr Asp 265 270 275 aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc gcc atg ctc gcc 979 Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe Ala Met Leu Ala 280 285 290 aca tcc gca gca ttt ctt atc att tgg ccc gaa cca cag tgg gcc atg 1027 Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro Gln Trp Ala Met 295 300 305 atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac tct gcc ctc gtc 1075 Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn Ser Ala Leu Val 310 315 320 325 ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc cac cac cgc acc 1123 Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile His His Arg Thr 330 335 340 tac gcc cag ggg cgc agc gac cta acg atg aat ctt gcg gga gct tca 1171 Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu Ala Gly Ala Ser 345 350 355 ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc gga atg ccc ttg 1219 Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly Gly Met Pro Leu 360 365 370 ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa acg gtg ctt agt 1267 Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln Thr Val Leu Ser 375 380 385 ttc aga acc cgt tca att gaa aag act cct gct tca tgt ttt 1309 Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser Cys Phe 390 395 400 tagcctagga attcacgcac gacggagtca 1339 <210> 146 <211> 403 <212> PRT <213> Corynebacterium glutamicum <400> 146 Met His Ala Ser Ser Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu 1 5 10 15 Ser Gly Leu Ile Phe Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val 20 25 30 Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser 35 40 45 Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe 50 55 60 Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser 65 70 75 80 Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile 85 90 95 Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu 100 105 110 Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala 115 120 125 Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val 130 135 140 Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu 145 150 155 160 Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly 165 170 175 Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp 180 185 190 Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala 195 200 205 Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr 210 215 220 Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met Ser Met Ala 225 230 235 240 Ala Ile His Met Gln Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe 245 250 255 Thr Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe 260 265 270 Gly Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly 275 280 285 Phe Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu 290 295 300 Pro Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp 305 310 315 320 Asn Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro 325 330 335 Ile His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn 340 345 350 Leu Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met 355 360 365 Gly Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu 370 375 380 Gln Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala 385 390 395 400 Ser Cys Phe <210> 147 <211> 772 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(742) <223> RXA02570 <400> 147 ccattgttat gctcattgtg tttgtggtgg tcaagtcgct acccaagcgc accactaggg 60 cattggttcc gcagcgggtt ccggaggacg tcgcttaaac atg aat cct ttg aca 115 Met Asn Pro Leu Thr 1 5 tgg atc att ggc gca ttc agc atg tgg atc gtg gtg ctg ggc gtt aat 163 Trp Ile Ile Gly Ala Phe Ser Met Trp Ile Val Val Leu Gly Val Asn 10 15 20 aag ctt ggt tta agc atc gca gtg atc atc atc gcg cag gtc gtg gcg 211 Lys Leu Gly Leu Ser Ile Ala Val Ile Ile Ile Ala Gln Val Val Ala 25 30 35 atg att cgg gtg cgc aat gta tct gtg ttg gct tca aca gca ttg tta 259 Met Ile Arg Val Arg Asn Val Ser Val Leu Ala Ser Thr Ala Leu Leu 40 45 50 tcg gtt cct gca ttg gcc tcg atg gcg ctg att cac atg ccg tat tct 307 Ser Val Pro Ala Leu Ala Ser Met Ala Leu Ile His Met Pro Tyr Ser 55 60 65 tcc gac ggc tgg ttg att gct ctt acc ttg acg gct cgt ttt agt gcg 355 Ser Asp Gly Trp Leu Ile Ala Leu Thr Leu Thr Ala Arg Phe Ser Ala 70 75 80 85 ttg atg tct att ttc ctc ctt gca gca aca gcg att act att cct gag 403 Leu Met Ser Ile Phe Leu Leu Ala Ala Thr Ala Ile Thr Ile Pro Glu 90 95 100 ctg gtg aaa tcc cta tat cgt tgg ccc aag ctg gcg tat atc gtg ggt 451 Leu Val Lys Ser Leu Tyr Arg Trp Pro Lys Leu Ala Tyr Ile Val Gly 105 110 115 tct gca ttg cag atg att ccg cag ggt aaa cag acc ttg gcg ttg gtt 499 Ser Ala Leu Gln Met Ile Pro Gln Gly Lys Gln Thr Leu Ala Leu Val 120 125 130 cgt gat gcc aat gct ttg cgc ggg cgc agc gtt aaa ggt ccc gtg cgc 547 Arg Asp Ala Asn Ala Leu Arg Gly Arg Ser Val Lys Gly Pro Val Arg 135 140 145 gcg gtg aaa tat gtg ggt ttg ccc ctg att aca cat tta ctt agt gca 595 Ala Val Lys Tyr Val Gly Leu Pro Leu Ile Thr His Leu Leu Ser Ala 150 155 160 165 ggt gcc gcg cga gcg att ccc ttg gag gtc gca ggc ctg gac agg ccg 643 Gly Ala Ala Arg Ala Ile Pro Leu Glu Val Ala Gly Leu Asp Arg Pro 170 175 180 ggg ccg cgt acg gtg ttg gtt gag gtg gtg gag ggg cgc gtc gaa aag 691 Gly Pro Arg Thr Val Leu Val Glu Val Val Glu Gly Arg Val Glu Lys 185 190 195 cat tgt cgc tgg ttg ttg ccg ctt ttg gca gtc ggg atg gcg tgg tgg 739 His Cys Arg Trp Leu Leu Pro Leu Leu Ala Val Gly Met Ala Trp Trp 200 205 210 ctc taactcaaat cgtcggaccg tccggctccg 772 Leu <210> 148 <211> 214 <212> PRT <213> Corynebacterium glutamicum <400> 148 Met Asn Pro Leu Thr Trp Ile Ile Gly Ala Phe Ser Met Trp Ile Val 1 5 10 15 Val Leu Gly Val Asn Lys Leu Gly Leu Ser Ile Ala Val Ile Ile Ile 20 25 30 Ala Gln Val Val Ala Met Ile Arg Val Arg Asn Val Ser Val Leu Ala 35 40 45 Ser Thr Ala Leu Leu Ser Val Pro Ala Leu Ala Ser Met Ala Leu Ile 50 55 60 His Met Pro Tyr Ser Ser Asp Gly Trp Leu Ile Ala Leu Thr Leu Thr 65 70 75 80 Ala Arg Phe Ser Ala Leu Met Ser Ile Phe Leu Leu Ala Ala Thr Ala 85 90 95 Ile Thr Ile Pro Glu Leu Val Lys Ser Leu Tyr Arg Trp Pro Lys Leu 100 105 110 Ala Tyr Ile Val Gly Ser Ala Leu Gln Met Ile Pro Gln Gly Lys Gln 115 120 125 Thr Leu Ala Leu Val Arg Asp Ala Asn Ala Leu Arg Gly Arg Ser Val 130 135 140 Lys Gly Pro Val Arg Ala Val Lys Tyr Val Gly Leu Pro Leu Ile Thr 145 150 155 160 His Leu Leu Ser Ala Gly Ala Ala Arg Ala Ile Pro Leu Glu Val Ala 165 170 175 Gly Leu Asp Arg Pro Gly Pro Arg Thr Val Leu Val Glu Val Val Glu 180 185 190 Gly Arg Val Glu Lys His Cys Arg Trp Leu Leu Pro Leu Leu Ala Val 195 200 205 Gly Met Ala Trp Trp Leu 210 <210> 149 <211> 1087 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1057) <223> RXA02613 <400> 149 agatatcccc ggcgatcgcc gcacccaccc ctcctttgcc tcctacaccg ctcaactcct 60 tgagtggctc gaaatcacca cacctgccta gaaagaaatc atg aaa ttt aag aaa 115 Met Lys Phe Lys Lys 1 5 atc gcc ctc gtt ctc gcc ttc ggt cta ggc ctt gca tcc tgc tca tca 163 Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu Ala Ser Cys Ser Ser 10 15 20 gct tct ggc gat ccc gcc acc aac gcc gat gga tcc atc gat ctg agc 211 Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly Ser Ile Asp Leu Ser 25 30 35 aaa gta acc ctt aac atc ggt gat caa atc gcc gga aca gaa caa gtg 259 Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala Gly Thr Glu Gln Val 40 45 50 ctc caa gct tca ggg gag cta gat gat gtc cct tat aaa atc gaa tgg 307 Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro Tyr Lys Ile Glu Trp 55 60 65 tca tca ttt acc tct gga cca ccc caa atc gaa gca tta aac gca ggt 355 Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu Ala Leu Asn Ala Gly 70 75 80 85 caa att gat ttc gcg atc acc gga aac acc cca ccg atc atc ggc ggc 403 Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro Pro Ile Ile Gly Gly 90 95 100 ccc acc aac acc aaa gtg gtc tcc gcc tac aac aac gat gct tta ggt 451 Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn Asn Asp Ala Leu Gly 105 110 115 gat gtc atc ttg gtc gcc ccg gat tct tca ata acc tcg gtg gct gac 499 Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile Thr Ser Val Ala Asp 120 125 130 ctt gct gga aag aaa gtg gct gtc gcc cgc gga tcc agc gcc cac gga 547 Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly Ser Ser Ala His Gly 135 140 145 cac ctc atc caa caa cta gaa aaa gca ggc gtg agc gtt gac gac gta 595 His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val Ser Val Asp Asp Val 150 155 160 165 gaa atc aac ctc ctc caa ccc tcc gac gcc aaa gcc gct ttc caa aac 643 Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys Ala Ala Phe Gln Asn 170 175 180 ggc cag gta gat gcg tgg gca gtg tgg gat ccc tac agc tca cag gcg 691 Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro Tyr Ser Ser Gln Ala 185 190 195 gaa ctg gaa gga gct caa gtt ttg gtc agg gga gcg gga ctg gtc agt 739 Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly Ala Gly Leu Val Ser 200 205 210 ggg cat gga ttt ggt gtc gca agt gat gaa gcg ctc gat gac ccc gca 787 Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala Leu Asp Asp Pro Ala 215 220 225 aag gaa gcc gcc ttg gca gat ttc ctc gat cgc gtg gcc gac tct tat 835 Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg Val Ala Asp Ser Tyr 230 235 240 245 gaa tgg gct gaa gac aac acc gat gaa tgg gcg acg att ttc agc caa 883 Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala Thr Ile Phe Ser Gln 250 255 260 gaa tcc ggc ttt gat ccg gag gcc tct caa ctg aac acc cgc agc ctg 931 Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu Asn Thr Arg Ser Leu 265 270 275 cgc cat cag gtg ccg ctc gac gag tcc gtc aac acc tat cag aac gcg 979 Arg His Gln Val Pro Leu Asp Glu Ser Val Asn Thr Tyr Gln Asn Ala 280 285 290 ctt atc gac gct ttc gtc tcc gcg ggt ctc gtt gag gac ttt aat ttc 1027 Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val Glu Asp Phe Asn Phe 295 300 305 gag gac acc gta gac acc cga ttt gag ggc taagtatgtc tgagtatggc 1077 Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 310 315 aaaggggcgt 1087 <210> 150 <211> 319 <212> PRT <213> Corynebacterium glutamicum <400> 150 Met Lys Phe Lys Lys Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu 1 5 10 15 Ala Ser Cys Ser Ser Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly 20 25 30 Ser Ile Asp Leu Ser Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala 35 40 45 Gly Thr Glu Gln Val Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro 50 55 60 Tyr Lys Ile Glu Trp Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu 65 70 75 80 Ala Leu Asn Ala Gly Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro 85 90 95 Pro Ile Ile Gly Gly Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn 100 105 110 Asn Asp Ala Leu Gly Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile 115 120 125 Thr Ser Val Ala Asp Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly 130 135 140 Ser Ser Ala His Gly His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val 145 150 155 160 Ser Val Asp Asp Val Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys 165 170 175 Ala Ala Phe Gln Asn Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro 180 185 190 Tyr Ser Ser Gln Ala Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly 195 200 205 Ala Gly Leu Val Ser Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala 210 215 220 Leu Asp Asp Pro Ala Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg 225 230 235 240 Val Ala Asp Ser Tyr Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala 245 250 255 Thr Ile Phe Ser Gln Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu 260 265 270 Asn Thr Arg Ser Leu Arg His Gln Val Pro Leu Asp Glu Ser Val Asn 275 280 285 Thr Tyr Gln Asn Ala Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val 290 295 300 Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 305 310 315 <210> 151 <211> 1144 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1114) <223> RXA02627 <400> 151 tcgcctattg ggggttattt tcgatgcccg atcacagtaa tctcgaacag gttaggtaag 60 gtttgcatac tttattttta tcctgaaggg acgggcgcca atg aaa aag cgt gtc 115 Met Lys Lys Arg Val 1 5 agt tta ttt aag tca gct gca tcg att gtg gtg gtt gcg gga atg gcg 163 Ser Leu Phe Lys Ser Ala Ala Ser Ile Val Val Val Ala Gly Met Ala 10 15 20 ttg ggt atg gtg ggt tgc tca tcg acc gaa tcg gag agt gaa tct agc 211 Leu Gly Met Val Gly Cys Ser Ser Thr Glu Ser Glu Ser Glu Ser Ser 25 30 35 gct gac gtg aca tca tct gcc gat ggg gca tat cca gtg tcc atc gcg 259 Ala Asp Val Thr Ser Ser Ala Asp Gly Ala Tyr Pro Val Ser Ile Ala 40 45 50 acc aaa ttc ggt gat gtc act gtg gaa agc caa cca gaa cgc gtc gtt 307 Thr Lys Phe Gly Asp Val Thr Val Glu Ser Gln Pro Glu Arg Val Val 55 60 65 gcc ctg ggt tgg gga gat gct gag gct gcg ctg gaa ttc ggt gtg cag 355 Ala Leu Gly Trp Gly Asp Ala Glu Ala Ala Leu Glu Phe Gly Val Gln 70 75 80 85 cct gtg ggt gca tca gat tgg ctc gca ttc ggt ggt gaa ggc gtg gga 403 Pro Val Gly Ala Ser Asp Trp Leu Ala Phe Gly Gly Glu Gly Val Gly 90 95 100 ccg tgg att gag gat tct gcc tac gat gaa gcg cca gaa ata atc gga 451 Pro Trp Ile Glu Asp Ser Ala Tyr Asp Glu Ala Pro Glu Ile Ile Gly 105 110 115 acc atg gaa ccg gag tat gaa aag att gca gcg ctt gaa ccg gat ctg 499 Thr Met Glu Pro Glu Tyr Glu Lys Ile Ala Ala Leu Glu Pro Asp Leu 120 125 130 att ttg gac gtg cgc agc tct ggc gac cag gaa cgc tat gac aag ttg 547 Ile Leu Asp Val Arg Ser Ser Gly Asp Gln Glu Arg Tyr Asp Lys Leu 135 140 145 tct tca atc gca ctg acc atc ggc gtt cca gaa ggt ggc gat agc tac 595 Ser Ser Ile Ala Leu Thr Ile Gly Val Pro Glu Gly Gly Asp Ser Tyr 150 155 160 165 ctc acc cca cgc gct gag cag gta acc atg atc gcc act gct ctg ggg 643 Leu Thr Pro Arg Ala Glu Gln Val Thr Met Ile Ala Thr Ala Leu Gly 170 175 180 cag gct gaa cgt ggt gaa gaa gtg aac gct gaa tac gag cag ctc act 691 Gln Ala Glu Arg Gly Glu Glu Val Asn Ala Glu Tyr Glu Gln Leu Thr 185 190 195 gct gat att cgt gca gct cac ccg ggc tgg cct gag aag acc gcg gct 739 Ala Asp Ile Arg Ala Ala His Pro Gly Trp Pro Glu Lys Thr Ala Ala 200 205 210 gct gta tct gca acg gca acc agc tgg ggt gca tac atc aag ggc tcc 787 Ala Val Ser Ala Thr Ala Thr Ser Trp Gly Ala Tyr Ile Lys Gly Ser 215 220 225 aac cgt gta gat act ttg ctg gac ctg ggc ttc cag gaa aac cct gag 835 Asn Arg Val Asp Thr Leu Leu Asp Leu Gly Phe Gln Glu Asn Pro Glu 230 235 240 245 ctg gct aaa cag caa cct ggc gat acg ggt ttc tcc atc aaa ttc agt 883 Leu Ala Lys Gln Gln Pro Gly Asp Thr Gly Phe Ser Ile Lys Phe Ser 250 255 260 gaa gag act ttc ggc gtt gtg gat tcc gac ctg gtt gtc ggc ttt gcc 931 Glu Glu Thr Phe Gly Val Val Asp Ser Asp Leu Val Val Gly Phe Ala 265 270 275 atc ggt atg act cct gag gaa atg gca gag cag gtt cca tgg cag atg 979 Ile Gly Met Thr Pro Glu Glu Met Ala Glu Gln Val Pro Trp Gln Met 280 285 290 ttg acc gcc act cgt gac ggc cgt tcc ttt gtg atg ccc cgt gag att 1027 Leu Thr Ala Thr Arg Asp Gly Arg Ser Phe Val Met Pro Arg Glu Ile 295 300 305 tcc aat gcg ttt tct ttg ggt tcc ccg cag tcc act cgg ttc gcg tta 1075 Ser Asn Ala Phe Ser Leu Gly Ser Pro Gln Ser Thr Arg Phe Ala Leu 310 315 320 325 gac gcc ttg gtg cca ctt ctg gag gag cat gca ggg gag tagtggtccg 1124 Asp Ala Leu Val Pro Leu Leu Glu Glu His Ala Gly Glu 330 335 gtggtgcggg cagggggtag 1144 <210> 152 <211> 338 <212> PRT <213> Corynebacterium glutamicum <400> 152 Met Lys Lys Arg Val Ser Leu Phe Lys Ser Ala Ala Ser Ile Val Val 1 5 10 15 Val Ala Gly Met Ala Leu Gly Met Val Gly Cys Ser Ser Thr Glu Ser 20 25 30 Glu Ser Glu Ser Ser Ala Asp Val Thr Ser Ser Ala Asp Gly Ala Tyr 35 40 45 Pro Val Ser Ile Ala Thr Lys Phe Gly Asp Val Thr Val Glu Ser Gln 50 55 60 Pro Glu Arg Val Val Ala Leu Gly Trp Gly Asp Ala Glu Ala Ala Leu 65 70 75 80 Glu Phe Gly Val Gln Pro Val Gly Ala Ser Asp Trp Leu Ala Phe Gly 85 90 95 Gly Glu Gly Val Gly Pro Trp Ile Glu Asp Ser Ala Tyr Asp Glu Ala 100 105 110 Pro Glu Ile Ile Gly Thr Met Glu Pro Glu Tyr Glu Lys Ile Ala Ala 115 120 125 Leu Glu Pro Asp Leu Ile Leu Asp Val Arg Ser Ser Gly Asp Gln Glu 130 135 140 Arg Tyr Asp Lys Leu Ser Ser Ile Ala Leu Thr Ile Gly Val Pro Glu 145 150 155 160 Gly Gly Asp Ser Tyr Leu Thr Pro Arg Ala Glu Gln Val Thr Met Ile 165 170 175 Ala Thr Ala Leu Gly Gln Ala Glu Arg Gly Glu Glu Val Asn Ala Glu 180 185 190 Tyr Glu Gln Leu Thr Ala Asp Ile Arg Ala Ala His Pro Gly Trp Pro 195 200 205 Glu Lys Thr Ala Ala Ala Val Ser Ala Thr Ala Thr Ser Trp Gly Ala 210 215 220 Tyr Ile Lys Gly Ser Asn Arg Val Asp Thr Leu Leu Asp Leu Gly Phe 225 230 235 240 Gln Glu Asn Pro Glu Leu Ala Lys Gln Gln Pro Gly Asp Thr Gly Phe 245 250 255 Ser Ile Lys Phe Ser Glu Glu Thr Phe Gly Val Val Asp Ser Asp Leu 260 265 270 Val Val Gly Phe Ala Ile Gly Met Thr Pro Glu Glu Met Ala Glu Gln 275 280 285 Val Pro Trp Gln Met Leu Thr Ala Thr Arg Asp Gly Arg Ser Phe Val 290 295 300 Met Pro Arg Glu Ile Ser Asn Ala Phe Ser Leu Gly Ser Pro Gln Ser 305 310 315 320 Thr Arg Phe Ala Leu Asp Ala Leu Val Pro Leu Leu Glu Glu His Ala 325 330 335 Gly Glu <210> 153 <211> 1519 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1489) <223> RXA02676 <400> 153 aaccattggg tattaagaaa tttgtggctt agatctcaat ttctgtatag tttgatcata 60 ctaattcatc cacttccaaa ttttcacgaa ggatcacccc atg gac acc tgg gaa 115 Met Asp Thr Trp Glu 1 5 caa acc ctt gga aca ggg cca ctg cta ggc att gca gcc ggc gcc att 163 Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile Ala Ala Gly Ala Ile 10 15 20 gcc ctc atc ttg gtt ctc gtc atc gtt ttt aaa ctc cat gct ttt ctc 211 Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys Leu His Ala Phe Leu 25 30 35 acc cta ata ctg gtt tca att gtt acc gca ctt gct gcc ggc att ccc 259 Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu Ala Ala Gly Ile Pro 40 45 50 gtc acc gca gta gtg gac act ctc ctt gac ggt ttt ggt aaa aca ctc 307 Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly Phe Gly Lys Thr Leu 55 60 65 gcc tcg gtc gcc cta ttg gta ggc ctg ggt gcc atg ctt ggt cga ttg 355 Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala Met Leu Gly Arg Leu 70 75 80 85 gtt gaa aca tcc ggt ggc gca aaa tct cta gcc gac act atg gtg cga 403 Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala Asp Thr Met Val Arg 90 95 100 atc ttc ggt gaa aaa cga gca gct ttc gca ctc ggt gtc gca tcg ctg 451 Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu Gly Val Ala Ser Leu 105 110 115 atc atg gga ttc cct atc ttc ttc gat gct ggc ctc gtg gtc atg ctc 499 Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly Leu Val Val Met Leu 120 125 130 cca gtg atc ttc gca gta gct cga cgc ctc aac ggc tcc gtc ctt act 547 Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn Gly Ser Val Leu Thr 135 140 145 ttt ggt atc cct gca gct ggc gcc ttc tct gtc atg cac gtg ttc gtc 595 Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val Met His Val Phe Val 150 155 160 165 cca cct cac cca ggc cca att gca gcc tct gaa ttc ttc ggc gca caa 643 Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu Phe Phe Gly Ala Gln 170 175 180 gtt gga tac gta cta atc gct ggc atc atc gtt gca cta ccc acc tgg 691 Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val Ala Leu Pro Thr Trp 185 190 195 tat tta acc ggt tac ctg cta ggt aag ttc tta ggc cga aag ttc ccc 739 Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu Gly Arg Lys Phe Pro 200 205 210 ctt ccc gta ccc gat cta ctc agt ggt gga gca cag gaa gat gat cag 787 Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala Gln Glu Asp Asp Gln 215 220 225 cct cag aac cca gct aac gca gtg tcg atc att gtc att ttg ctc att 835 Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile Val Ile Leu Leu Ile 230 235 240 245 cct atg ctc ctt att ttt ggc aat acc gga aca tca atg gca gtt tcc 883 Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr Ser Met Ala Val Ser 250 255 260 gcc ggc ctc cta gat gca gaa tcc acc atg gtg aaa att cta gga ttc 931 Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val Lys Ile Leu Gly Phe 265 270 275 ctc ggc gaa aca cca gtg gca ctg ctc att acc ttg atc att gcc ctg 979 Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr Leu Ile Ile Ala Leu 280 285 290 ttc ttc cta ggc aac cga cgt ggc att aat ggt tct gct cta gag aaa 1027 Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly Ser Ala Leu Glu Lys 295 300 305 acc atc gaa ggc gca ctc ggc cca atc tgt tca gtc gta tta atc act 1075 Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser Val Val Leu Ile Thr 310 315 320 325 ggc gcc ggt ggc atg ttc ggt gga gtg cta cgc acg tct gga att gga 1123 Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg Thr Ser Gly Ile Gly 330 335 340 gga gcg ctt gca gac tcc atg gca gat cta gga ctt cca gtt atc gca 1171 Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly Leu Pro Val Ile Ala 345 350 355 ggt tgt ttc atc gtg gca gcc gtc ctt cgt gtc gcg cag ggt tct gcc 1219 Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val Ala Gln Gly Ser Ala 360 365 370 acc gtt gcg cta acc acc gcc gca gca ctc atg gca cct gct gtt gcc 1267 Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met Ala Pro Ala Val Ala 375 380 385 gct gct gac ttt aac gaa ttc cag ctt gct gcc atc gtt att tcc act 1315 Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala Ile Val Ile Ser Thr 390 395 400 405 gcc gct ggt tct gtt att gcc agc cac gtc aac gac tcc gga ttc tgg 1363 Ala Ala Gly Ser Val Ile Ala Ser His Val Asn Asp Ser Gly Phe Trp 410 415 420 ctc gtt ggt cga ctc atg aac gcc gac gta ccc acc acg cta aaa act 1411 Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro Thr Thr Leu Lys Thr 425 430 435 tgg acc gta aac caa acc tgc att gcg att gtg gga ttt gtg atg gcc 1459 Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val Gly Phe Val Met Ala 440 445 450 tat gca atg ttc gga ttg gca tcg ctt gca tagtccgctg accccattga 1509 Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala 455 460 ttcacaggct 1519 <210> 154 <211> 463 <212> PRT <213> Corynebacterium glutamicum <400> 154 Met Asp Thr Trp Glu Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile 1 5 10 15 Ala Ala Gly Ala Ile Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys 20 25 30 Leu His Ala Phe Leu Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu 35 40 45 Ala Ala Gly Ile Pro Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly 50 55 60 Phe Gly Lys Thr Leu Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala 65 70 75 80 Met Leu Gly Arg Leu Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala 85 90 95 Asp Thr Met Val Arg Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu 100 105 110 Gly Val Ala Ser Leu Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly 115 120 125 Leu Val Val Met Leu Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn 130 135 140 Gly Ser Val Leu Thr Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val 145 150 155 160 Met His Val Phe Val Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu 165 170 175 Phe Phe Gly Ala Gln Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val 180 185 190 Ala Leu Pro Thr Trp Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu 195 200 205 Gly Arg Lys Phe Pro Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala 210 215 220 Gln Glu Asp Asp Gln Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile 225 230 235 240 Val Ile Leu Leu Ile Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr 245 250 255 Ser Met Ala Val Ser Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val 260 265 270 Lys Ile Leu Gly Phe Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr 275 280 285 Leu Ile Ile Ala Leu Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly 290 295 300 Ser Ala Leu Glu Lys Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser 305 310 315 320 Val Val Leu Ile Thr Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg 325 330 335 Thr Ser Gly Ile Gly Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly 340 345 350 Leu Pro Val Ile Ala Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val 355 360 365 Ala Gln Gly Ser Ala Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met 370 375 380 Ala Pro Ala Val Ala Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala 385 390 395 400 Ile Val Ile Ser Thr Ala Ala Gly Ser Val Ile Ala Ser His Val Asn 405 410 415 Asp Ser Gly Phe Trp Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro 420 425 430 Thr Thr Leu Lys Thr Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val 435 440 445 Gly Phe Val Met Ala Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala 450 455 460 <210> 155 <211> 949 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(919) <223> RXA02677 <400> 155 acattttcct cgtagatcct tgctaggtcg tgaaaagaaa aagtaatctg catcacaaaa 60 ttagtgcagt gtatttattt ccgttcacgc tgcggggctg gtg gtt tgg agg gat 115 Val Val Trp Arg Asp 1 5 act aga gtc gat agc agg tat ata aag gcc agg aga gat ggg ttc atg 163 Thr Arg Val Asp Ser Arg Tyr Ile Lys Ala Arg Arg Asp Gly Phe Met 10 15 20 aaa gtc atc gcg cac cga ggt tta tcg tct cgc ttt ccc gaa tta aca 211 Lys Val Ile Ala His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu Thr 25 30 35 gag tct gcg ttt cgg gcg gct cta gag cta ccg att cat gga att gaa 259 Glu Ser Ala Phe Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile Glu 40 45 50 act gat gtc cgg ctg act aaa tgt ggc gaa gtg gtt aac gtc cat gac 307 Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val Val Asn Val His Asp 55 60 65 ccc att gtg gat cgc gtg tcg aat ggt cgc ggt cgg gtg tcg cgt ttg 355 Pro Ile Val Asp Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg Leu 70 75 80 85 gac ttg gaa tcc ttg ctg agc ttg aac ttt gga acc aaa gaa acc cca 403 Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr Pro 90 95 100 gaa aaa gtg ctt act tta aac aat cta tta gat att ttt gag gat tat 451 Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp Tyr 105 110 115 cca gat aag cac ctt tat ata gaa acc aag cac cca atg cgc tac gcg 499 Pro Asp Lys His Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr Ala 120 125 130 gtc atg ctg gaa gaa gaa atc aca aaa atc tta aaa tat cgt ggg ctg 547 Val Met Leu Glu Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly Leu 135 140 145 acg gaa gac cca cgc atc cac atc att tct ttt gca ctt ccc gcg atg 595 Thr Glu Asp Pro Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala Met 150 155 160 165 tat cgc atg gct cgc ctt gct cca cag ctt gat cgc att cat ctg cgc 643 Tyr Arg Met Ala Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu Arg 170 175 180 agg tcg tgg gag cgt tgg ggt aat ccg cgc gat gtg cgc tgc ggt gta 691 Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly Val 185 190 195 ccc acc ggt ttg ggg ttg tcg ctg gag cgg gcg aag atg gat cca agg 739 Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro Arg 200 205 210 atg att ggg gcg aaa ggg tta ccc acc tat ctt ttc acc gtc gat aag 787 Met Ile Gly Ala Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp Lys 215 220 225 caa aaa gac atg ctg tgg gcg cgc gaa cag ggc gtc gac atg ctc gcc 835 Gln Lys Asp Met Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu Ala 230 235 240 245 acc aat tat ccg gac cgt gcg gcg gag ctt ttg aac gca cat ccc aag 883 Thr Asn Tyr Pro Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro Lys 250 255 260 ccc gcc atg tac gct aat gcg cat ggc aaa gaa gac taagaagaat 929 Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp 265 270 gaacagctgc cggagggcat 949 <210> 156 <211> 273 <212> PRT <213> Corynebacterium glutamicum <400> 156 Val Val Trp Arg Asp Thr Arg Val Asp Ser Arg Tyr Ile Lys Ala Arg 1 5 10 15 Arg Asp Gly Phe Met Lys Val Ile Ala His Arg Gly Leu Ser Ser Arg 20 25 30 Phe Pro Glu Leu Thr Glu Ser Ala Phe Arg Ala Ala Leu Glu Leu Pro 35 40 45 Ile His Gly Ile Glu Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val 50 55 60 Val Asn Val His Asp Pro Ile Val Asp Arg Val Ser Asn Gly Arg Gly 65 70 75 80 Arg Val Ser Arg Leu Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly 85 90 95 Thr Lys Glu Thr Pro Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp 100 105 110 Ile Phe Glu Asp Tyr Pro Asp Lys His Leu Tyr Ile Glu Thr Lys His 115 120 125 Pro Met Arg Tyr Ala Val Met Leu Glu Glu Glu Ile Thr Lys Ile Leu 130 135 140 Lys Tyr Arg Gly Leu Thr Glu Asp Pro Arg Ile His Ile Ile Ser Phe 145 150 155 160 Ala Leu Pro Ala Met Tyr Arg Met Ala Arg Leu Ala Pro Gln Leu Asp 165 170 175 Arg Ile His Leu Arg Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp 180 185 190 Val Arg Cys Gly Val Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Ala 195 200 205 Lys Met Asp Pro Arg Met Ile Gly Ala Lys Gly Leu Pro Thr Tyr Leu 210 215 220 Phe Thr Val Asp Lys Gln Lys Asp Met Leu Trp Ala Arg Glu Gln Gly 225 230 235 240 Val Asp Met Leu Ala Thr Asn Tyr Pro Asp Arg Ala Ala Glu Leu Leu 245 250 255 Asn Ala His Pro Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu 260 265 270 Asp <210> 157 <211> 1372 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1342) <223> RXA02684 <400> 157 taaactgaag ttcctatttt attgggatta gaaaaacacg agagatttaa ggcaaatccg 60 ctaaatacat ctgtccctcc taggcgctac tctattaacc atg gat tca cca gga 115 Met Asp Ser Pro Gly 1 5 cag ggc gag att gcc cgc gat agt caa gga cgc ccg ata ctg gac cgg 163 Gln Gly Glu Ile Ala Arg Asp Ser Gln Gly Arg Pro Ile Leu Asp Arg 10 15 20 tat ggt cgg ccg gtt cgg gtt cgt ccg caa ccg cgg caa act ccc ccg 211 Tyr Gly Arg Pro Val Arg Val Arg Pro Gln Pro Arg Gln Thr Pro Pro 25 30 35 act cct cga acc cct ccg gtg aat gaa aca agg gtc tat cag cca agg 259 Thr Pro Arg Thr Pro Pro Val Asn Glu Thr Arg Val Tyr Gln Pro Arg 40 45 50 caa acg cca ccg cgc cag act cct cca agg cag aca cct cca cga caa 307 Gln Thr Pro Pro Arg Gln Thr Pro Pro Arg Gln Thr Pro Pro Arg Gln 55 60 65 atg cct cct agg caa acc cca ccg agg cag gtt ccc cca caa cag cag 355 Met Pro Pro Arg Gln Thr Pro Pro Arg Gln Val Pro Pro Gln Gln Gln 70 75 80 85 tac cag cag cct ggt cag atc ggg cag gtt cgt cca cag ccg ccg gtg 403 Tyr Gln Gln Pro Gly Gln Ile Gly Gln Val Arg Pro Gln Pro Pro Val 90 95 100 att gca ggg gat ggg ggg agg cgt cga aaa gca ata tct ttt aag ccc 451 Ile Ala Gly Asp Gly Gly Arg Arg Arg Lys Ala Ile Ser Phe Lys Pro 105 110 115 cgt ggc tgc ctg ggc acg atc gcg ggc gtg ctt gct gtg ggc ttg gtg 499 Arg Gly Cys Leu Gly Thr Ile Ala Gly Val Leu Ala Val Gly Leu Val 120 125 130 ctt gtg ttt gtg gtg acg ctg tgg gcg gat tcg aag ctg aat cgc gtg 547 Leu Val Phe Val Val Thr Leu Trp Ala Asp Ser Lys Leu Asn Arg Val 135 140 145 gat gcc acg cct gcg acg cag gtg gcg aac act gcc gga acg aac tgg 595 Asp Ala Thr Pro Ala Thr Gln Val Ala Asn Thr Ala Gly Thr Asn Trp 150 155 160 165 ctg ctg gta ggt tcg gat tcg cgg cag ggt tta agt gat gag gat att 643 Leu Leu Val Gly Ser Asp Ser Arg Gln Gly Leu Ser Asp Glu Asp Ile 170 175 180 gag cgg cta ggt acc ggc ggc gat atc ggt gtg ggc cgt acg gac acg 691 Glu Arg Leu Gly Thr Gly Gly Asp Ile Gly Val Gly Arg Thr Asp Thr 185 190 195 atc atg gtg ttg cat atg ccg cgt act ggc gag ccg acg ctg ttg tcg 739 Ile Met Val Leu His Met Pro Arg Thr Gly Glu Pro Thr Leu Leu Ser 200 205 210 att ccg cgt gat tct tat gtc aat gtc cct ggc tgg ggc atg gat aag 787 Ile Pro Arg Asp Ser Tyr Val Asn Val Pro Gly Trp Gly Met Asp Lys 215 220 225 gca aac gcc gca ttt acc gtg ggt ggc ccg gaa ctg ctg acg caa acc 835 Ala Asn Ala Ala Phe Thr Val Gly Gly Pro Glu Leu Leu Thr Gln Thr 230 235 240 245 gtg gag gag gca act ggc ctg cga att gat cac tat gca gaa atc ggc 883 Val Glu Glu Ala Thr Gly Leu Arg Ile Asp His Tyr Ala Glu Ile Gly 250 255 260 atg ggt ggt ttg gcg aac atg gtt gat gcc gtg ggc ggc gtg gaa atg 931 Met Gly Gly Leu Ala Asn Met Val Asp Ala Val Gly Gly Val Glu Met 265 270 275 tgt cct gct gag ccg atg tat gat ccg ctc gcg aac ctg gat att cag 979 Cys Pro Ala Glu Pro Met Tyr Asp Pro Leu Ala Asn Leu Asp Ile Gln 280 285 290 gct ggt tgc cag gaa ttt gat ggg gca gcc gcg ctg ggt tat gtg cgc 1027 Ala Gly Cys Gln Glu Phe Asp Gly Ala Ala Ala Leu Gly Tyr Val Arg 295 300 305 act cgt gcc aca gcc ctg ggt gat ctg gac cgg gtg gtg cgt cag cgg 1075 Thr Arg Ala Thr Ala Leu Gly Asp Leu Asp Arg Val Val Arg Gln Arg 310 315 320 325 gaa ttc ttc tcc gct ctg ctg agt aca gct acg tcc ccg ggc acg ttg 1123 Glu Phe Phe Ser Ala Leu Leu Ser Thr Ala Thr Ser Pro Gly Thr Leu 330 335 340 ctg aat ccg ttc cgc acc ttc ccg atg atc tcc aac gcg gtg gga aca 1171 Leu Asn Pro Phe Arg Thr Phe Pro Met Ile Ser Asn Ala Val Gly Thr 345 350 355 ttc acc gtc ggc gag ggc gat cac gtg tgg cac ctg gcc cga ttg gcg 1219 Phe Thr Val Gly Glu Gly Asp His Val Trp His Leu Ala Arg Leu Ala 360 365 370 ctg gcg atg cgc gga gga atc gtg acg gag acc gtg ccg att gcc tca 1267 Leu Ala Met Arg Gly Gly Ile Val Thr Glu Thr Val Pro Ile Ala Ser 375 380 385 ttc gca gat tac gat gtg gga aat gtt gcg att tgg gac gaa gct gga 1315 Phe Ala Asp Tyr Asp Val Gly Asn Val Ala Ile Trp Asp Glu Ala Gly 390 395 400 405 gcc gaa gca cta ttt agc tcc atg cgc taaaacccca ggtaatcgtt 1362 Ala Glu Ala Leu Phe Ser Ser Met Arg 410 cacaggaagt 1372 <210> 158 <211> 414 <212> PRT <213> Corynebacterium glutamicum <400> 158 Met Asp Ser Pro Gly Gln Gly Glu Ile Ala Arg Asp Ser Gln Gly Arg 1 5 10 15 Pro Ile Leu Asp Arg Tyr Gly Arg Pro Val Arg Val Arg Pro Gln Pro 20 25 30 Arg Gln Thr Pro Pro Thr Pro Arg Thr Pro Pro Val Asn Glu Thr Arg 35 40 45 Val Tyr Gln Pro Arg Gln Thr Pro Pro Arg Gln Thr Pro Pro Arg Gln 50 55 60 Thr Pro Pro Arg Gln Met Pro Pro Arg Gln Thr Pro Pro Arg Gln Val 65 70 75 80 Pro Pro Gln Gln Gln Tyr Gln Gln Pro Gly Gln Ile Gly Gln Val Arg 85 90 95 Pro Gln Pro Pro Val Ile Ala Gly Asp Gly Gly Arg Arg Arg Lys Ala 100 105 110 Ile Ser Phe Lys Pro Arg Gly Cys Leu Gly Thr Ile Ala Gly Val Leu 115 120 125 Ala Val Gly Leu Val Leu Val Phe Val Val Thr Leu Trp Ala Asp Ser 130 135 140 Lys Leu Asn Arg Val Asp Ala Thr Pro Ala Thr Gln Val Ala Asn Thr 145 150 155 160 Ala Gly Thr Asn Trp Leu Leu Val Gly Ser Asp Ser Arg Gln Gly Leu 165 170 175 Ser Asp Glu Asp Ile Glu Arg Leu Gly Thr Gly Gly Asp Ile Gly Val 180 185 190 Gly Arg Thr Asp Thr Ile Met Val Leu His Met Pro Arg Thr Gly Glu 195 200 205 Pro Thr Leu Leu Ser Ile Pro Arg Asp Ser Tyr Val Asn Val Pro Gly 210 215 220 Trp Gly Met Asp Lys Ala Asn Ala Ala Phe Thr Val Gly Gly Pro Glu 225 230 235 240 Leu Leu Thr Gln Thr Val Glu Glu Ala Thr Gly Leu Arg Ile Asp His 245 250 255 Tyr Ala Glu Ile Gly Met Gly Gly Leu Ala Asn Met Val Asp Ala Val 260 265 270 Gly Gly Val Glu Met Cys Pro Ala Glu Pro Met Tyr Asp Pro Leu Ala 275 280 285 Asn Leu Asp Ile Gln Ala Gly Cys Gln Glu Phe Asp Gly Ala Ala Ala 290 295 300 Leu Gly Tyr Val Arg Thr Arg Ala Thr Ala Leu Gly Asp Leu Asp Arg 305 310 315 320 Val Val Arg Gln Arg Glu Phe Phe Ser Ala Leu Leu Ser Thr Ala Thr 325 330 335 Ser Pro Gly Thr Leu Leu Asn Pro Phe Arg Thr Phe Pro Met Ile Ser 340 345 350 Asn Ala Val Gly Thr Phe Thr Val Gly Glu Gly Asp His Val Trp His 355 360 365 Leu Ala Arg Leu Ala Leu Ala Met Arg Gly Gly Ile Val Thr Glu Thr 370 375 380 Val Pro Ile Ala Ser Phe Ala Asp Tyr Asp Val Gly Asn Val Ala Ile 385 390 395 400 Trp Asp Glu Ala Gly Ala Glu Ala Leu Phe Ser Ser Met Arg 405 410 <210> 159 <211> 1243 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1213) <223> RXA02718 <400> 159 gacatgcctg ggtatcttag tgtgatgaga gtgttttgtt gggactgcct ctggcattta 60 ttcacctcca ccaaaattca gcccgcatcc ccctattcga ttg aag gac gtc tcc 115 Leu Lys Asp Val Ser 1 5 ttg agc agt ttc gat gcc cat gac ctt gac ctc gac aaa ttt ccg gag 163 Leu Ser Ser Phe Asp Ala His Asp Leu Asp Leu Asp Lys Phe Pro Glu 10 15 20 gtc gtg cga gat cgt ttg acg cag ttc ctc gat gct caa gag cta aca 211 Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr 25 30 35 att gct gat atc ggc gct cct gtc aca gat gct gtg gcc cat ctt cgc 259 Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala Val Ala His Leu Arg 40 45 50 agt ttc gtg ctc aat gga gga aag cga atc cgt cct ctt tat gcg tgg 307 Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp 55 60 65 gct ggt ttc ctg gcg gcg caa ggc cat aag aat tct tct gaa aaa ctt 355 Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn Ser Ser Glu Lys Leu 70 75 80 85 gag tcc gtc ctt gac gcc gca gcg agt ctc gaa ttc atc cag gct tgt 403 Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys 90 95 100 gcc ttg att cat gac gat att atc gat tct tct gat acc cgg cgc gga 451 Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly 105 110 115 gcc ccc aca gtt cac cgg gct gtg gaa gct gat cac cgc gcc aat aat 499 Ala Pro Thr Val His Arg Ala Val Glu Ala Asp His Arg Ala Asn Asn 120 125 130 ttc gaa ggc gat ccc gag cac ttt ggc gtt tca gtc tcg att ttg gct 547 Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser Ile Leu Ala 135 140 145 ggc gat atg gca ttg gtg tgg gca gaa gac atg ctg cag gat tcc ggt 595 Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser Gly 150 155 160 165 ttg agt gca gag gca ttg gcc cgc acg agg gat gct tgg cgt ggc atg 643 Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly Met 170 175 180 cgt act gag gtt att ggc ggc cag ctg ctt gat att tat cta gag tcg 691 Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser 185 190 195 cac gcc aac gag tcg gtg gag ctt gcg gat tct gtc aac cgc ttc aaa 739 His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser Val Asn Arg Phe Lys 200 205 210 acg gcc gct tac acg att gcg cgc cca ttg cac ctg ggc gcc tcc att 787 Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser Ile 215 220 225 gct ggc ggt tcg ccg cag ctt atc gac gcg ctc ctc cac tac ggc cac 835 Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu Leu His Tyr Gly His 230 235 240 245 gac atc ggc att gca ttc cag ttg agg gat gat ctg ctt ggt gtg ttt 883 Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe 250 255 260 ggg gat ccc gct atc acc ggc aaa cca gct gga gac gat atc cgt gaa 931 Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu 265 270 275 ggc aag cgc act gtt ctt ctt gcg ctc gct cta caa cgc gct gat aag 979 Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys 280 285 290 caa tct cct gaa gct gca acg gcc att cgc gca ggt gtt gga aag gtg 1027 Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala Gly Val Gly Lys Val 295 300 305 act tca cca gaa gat att gct gtc att aca gag cat att cga gct act 1075 Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu His Ile Arg Ala Thr 310 315 320 325 ggt gct gaa gaa gaa gtt gag cag cga att tcc cag ctg act gaa tcc 1123 Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser 330 335 340 ggt ttg gct cac ctc gat gat gta gac atc ccc gat gag gtg cgc gca 1171 Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro Asp Glu Val Arg Ala 345 350 355 cag ttg cgg gca ctg gct atc cgc tca acc gaa cgt cgg atg 1213 Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met 360 365 370 tagtagacgc gtatgacact ttttcaacgt 1243 <210> 160 <211> 371 <212> PRT <213> Corynebacterium glutamicum <400> 160 Leu Lys Asp Val Ser Leu Ser Ser Phe Asp Ala His Asp Leu Asp Leu 1 5 10 15 Asp Lys Phe Pro Glu Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp 20 25 30 Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala 35 40 45 Val Ala His Leu Arg Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg 50 55 60 Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn 65 70 75 80 Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu 85 90 95 Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser 100 105 110 Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg Ala Val Glu Ala Asp 115 120 125 His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser 130 135 140 Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met 145 150 155 160 Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp 165 170 175 Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp 180 185 190 Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser 195 200 205 Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His 210 215 220 Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu 225 230 235 240 Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp 245 250 255 Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly 260 265 270 Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu 275 280 285 Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala 290 295 300 Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu 305 310 315 320 His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser 325 330 335 Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro 340 345 350 Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu 355 360 365 Arg Arg Met 370 <210> 161 <211> 922 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(892) <223> RXA02767 <400> 161 ggacgatgag ggaaaacgtt tcctcgccgc ccacagaatc ataaaaattt tctgaggttg 60 tcatgggtac cagtctaagc cctggcctta cgccagtaag gtg tta ccc atg cgc 115 Val Leu Pro Met Arg 1 5 gaa cta gca ctc aac atg gcc ggc gtc acc gtg cgg cgc ggc gag aaa 163 Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly Glu Lys 10 15 20 ttg ctt ctc gac gat atc tcc ctc tca att ccg caa ggg tcg cac tgg 211 Leu Leu Leu Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser His Trp 25 30 35 gcc gta ctt ggt cca aat ggc gcc ggt aaa acc acc atg ctg aag atc 259 Ala Val Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu Lys Ile 40 45 50 gca gcc acc ttg ctg tac cca tcg gaa ggc acc gtg gac atc ctg ggg 307 Ala Ala Thr Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile Leu Gly 55 60 65 cat cgc ttt ggt cgg gtg gat act cgt gag ctg cgg aaa aca atc ggc 355 His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr Ile Gly 70 75 80 85 ctg gtg gac ccg aag caa aga ttt acc aac ctg ccg gcc cac gaa att 403 Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His Glu Ile 90 95 100 gtg ctg tcg ggg tta acc gcc tcc aac ggg ttg ttg cca cgg tgg tcg 451 Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg Trp Ser 105 110 115 gct tcg gct tcg gag ttg gag cgg tgc gct ttg atg ttg gag ttg gtg 499 Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu Leu Val 120 125 130 ggc atg aca gcg cgt gcc gat cgt tac tgg gcc gat atg agc cag ggc 547 Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser Gln Gly 135 140 145 gaa aaa gcc cgc acc ctg att gct cgt gcg ctg att atc tca ccg acc 595 Glu Lys Ala Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser Pro Thr 150 155 160 165 cta ctg ctg ctt gat gaa ccc acc acc ggc ctt gac ctg ccc gga cgt 643 Leu Leu Leu Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro Gly Arg 170 175 180 gaa act ttg ctc agt gtg att gat ggt ttg cga gcc gct ctt cct ggt 691 Glu Thr Leu Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu Pro Gly 185 190 195 ctg acg aca gtg atg atc acc cac cac gtc gaa gag atc gcc gcc tcc 739 Leu Thr Thr Val Met Ile Thr His His Val Glu Glu Ile Ala Ala Ser 200 205 210 acg aca gat atc ctc atg atc aag gac gcc cgc ata ctg gct tcg ggg 787 Thr Thr Asp Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala Ser Gly 215 220 225 act gtt tca gaa gtg atg act cct gaa aat ttg ggc gcg ctg tat gac 835 Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu Tyr Asp 230 235 240 245 atg tcg gtg tcg ttg gaa act gtg cgc agc cgg tgg ttc gcg ttc gat 883 Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala Phe Asp 250 255 260 gct ctg cat taaaaggggc tagttttaca caaaagtgga 922 Ala Leu His <210> 162 <211> 264 <212> PRT <213> Corynebacterium glutamicum <400> 162 Val Leu Pro Met Arg Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val 1 5 10 15 Arg Arg Gly Glu Lys Leu Leu Leu Asp Asp Ile Ser Leu Ser Ile Pro 20 25 30 Gln Gly Ser His Trp Ala Val Leu Gly Pro Asn Gly Ala Gly Lys Thr 35 40 45 Thr Met Leu Lys Ile Ala Ala Thr Leu Leu Tyr Pro Ser Glu Gly Thr 50 55 60 Val Asp Ile Leu Gly His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu 65 70 75 80 Arg Lys Thr Ile Gly Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu 85 90 95 Pro Ala His Glu Ile Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu 100 105 110 Leu Pro Arg Trp Ser Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu 115 120 125 Met Leu Glu Leu Val Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala 130 135 140 Asp Met Ser Gln Gly Glu Lys Ala Arg Thr Leu Ile Ala Arg Ala Leu 145 150 155 160 Ile Ile Ser Pro Thr Leu Leu Leu Leu Asp Glu Pro Thr Thr Gly Leu 165 170 175 Asp Leu Pro Gly Arg Glu Thr Leu Leu Ser Val Ile Asp Gly Leu Arg 180 185 190 Ala Ala Leu Pro Gly Leu Thr Thr Val Met Ile Thr His His Val Glu 195 200 205 Glu Ile Ala Ala Ser Thr Thr Asp Ile Leu Met Ile Lys Asp Ala Arg 210 215 220 Ile Leu Ala Ser Gly Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu 225 230 235 240 Gly Ala Leu Tyr Asp Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg 245 250 255 Trp Phe Ala Phe Asp Ala Leu His 260 <210> 163 <211> 1630 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1600) <223> RXA02795 <400> 163 gatcccagct ggggtcgcat gttgcaaacc gctcaagcat ccatcggcgt cacccccatg 60 ttggcggtgt ggcccggtgc tgcgatcgct ttgacggtcc ttg gtt tta atc ttt 115 Leu Val Leu Ile Phe 1 5 tcg gtg atg gtt tac gcg atg cca tcg atc caa agc ggg agg tcg gcc 163 Ser Val Met Val Tyr Ala Met Pro Ser Ile Gln Ser Gly Arg Ser Ala 10 15 20 gtg ctt aaa gtt tct gat tta acg gtt ggc aac aat ttt gtc cac aac 211 Val Leu Lys Val Ser Asp Leu Thr Val Gly Asn Asn Phe Val His Asn 25 30 35 gtc tcc ttc gag gtc aac ccc ggc gaa cgc gtc ggc atc atc ggc gag 259 Val Ser Phe Glu Val Asn Pro Gly Glu Arg Val Gly Ile Ile Gly Glu 40 45 50 tcc ggc tca ggc aaa tca ctc acc gcg cta tcc atc atg ggt tta act 307 Ser Gly Ser Gly Lys Ser Leu Thr Ala Leu Ser Ile Met Gly Leu Thr 55 60 65 gac ctg ccg acc acc ggc cag atc acc ttc aac ggc aaa ccc tcc gct 355 Asp Leu Pro Thr Thr Gly Gln Ile Thr Phe Asn Gly Lys Pro Ser Ala 70 75 80 85 aca ttc cgt ggc acc cgc atc gcc atg gtt ttc caa gaa cca atg agc 403 Thr Phe Arg Gly Thr Arg Ile Ala Met Val Phe Gln Glu Pro Met Ser 90 95 100 gca ctc aac ccg ctc atg cgc atc ggc cgc caa atc gaa gaa atg atg 451 Ala Leu Asn Pro Leu Met Arg Ile Gly Arg Gln Ile Glu Glu Met Met 105 110 115 acc ctg cac ggg gca agc aaa aaa gac gcg cgg gcg cgc tta aaa agc 499 Thr Leu His Gly Ala Ser Lys Lys Asp Ala Arg Ala Arg Leu Lys Ser 120 125 130 ttg ctt atc gac gtc tcc ctc ccc gaa cgc acc gct tcg gcc tac cca 547 Leu Leu Ile Asp Val Ser Leu Pro Glu Arg Thr Ala Ser Ala Tyr Pro 135 140 145 cac gaa ctt tca ggc ggg caa cgc caa cgc gca cta atc gca atg gcg 595 His Glu Leu Ser Gly Gly Gln Arg Gln Arg Ala Leu Ile Ala Met Ala 150 155 160 165 ctg gcc aat gat cct gac ctg ttg atc tgc gat gaa ccc acc acg gct 643 Leu Ala Asn Asp Pro Asp Leu Leu Ile Cys Asp Glu Pro Thr Thr Ala 170 175 180 ttg gat gtg gtt gtg caa aaa caa atc gtc gat ctg ctg ctg cgt ctc 691 Leu Asp Val Val Val Gln Lys Gln Ile Val Asp Leu Leu Leu Arg Leu 185 190 195 acc aaa gaa cgt ggc acc gct tta ttg ttc atc acc cac gat ctt gga 739 Thr Lys Glu Arg Gly Thr Ala Leu Leu Phe Ile Thr His Asp Leu Gly 200 205 210 ctc atc gcg cgc acc tgc gaa cgc tta ttg gtg atg aaa tcc ggc gaa 787 Leu Ile Ala Arg Thr Cys Glu Arg Leu Leu Val Met Lys Ser Gly Glu 215 220 225 acc gta gaa cgc ggc gac acc gag gca att ctt cgc tcc ccc gcc cat 835 Thr Val Glu Arg Gly Asp Thr Glu Ala Ile Leu Arg Ser Pro Ala His 230 235 240 245 tcg tat acc caa cag ctc ctt gat gct tca atc ctt gac cag cca gaa 883 Ser Tyr Thr Gln Gln Leu Leu Asp Ala Ser Ile Leu Asp Gln Pro Glu 250 255 260 atc gcc tca gat tct ggc gcg ccg gta gtg att gat gtg gag gag gcg 931 Ile Ala Ser Asp Ser Gly Ala Pro Val Val Ile Asp Val Glu Glu Ala 265 270 275 tcg aaa agc ttt aaa gaa acc acc gcc ctc cac aag gtt tca ttg gcg 979 Ser Lys Ser Phe Lys Glu Thr Thr Ala Leu His Lys Val Ser Leu Ala 280 285 290 gtg cgc aaa ggt gac ctg ctt gga ata gtc ggc gga tca ggt tcc ggc 1027 Val Arg Lys Gly Asp Leu Leu Gly Ile Val Gly Gly Ser Gly Ser Gly 295 300 305 aaa acg act ctg ctg aag ctc atc gcc ggt ttg gat aag ccc aca acc 1075 Lys Thr Thr Leu Leu Lys Leu Ile Ala Gly Leu Asp Lys Pro Thr Thr 310 315 320 325 ggt acc gtt gcg gta acc ggt ggt gtg cag atg gtg ttt cag gat ccc 1123 Gly Thr Val Ala Val Thr Gly Gly Val Gln Met Val Phe Gln Asp Pro 330 335 340 caa tca agc ctc aac cca cgg atg aaa atc aaa gac att gtc gcc gaa 1171 Gln Ser Ser Leu Asn Pro Arg Met Lys Ile Lys Asp Ile Val Ala Glu 345 350 355 cca ctg ctt ggt tgg aac gcg gcg gag aaa acc aca cgg gtt gcg gaa 1219 Pro Leu Leu Gly Trp Asn Ala Ala Glu Lys Thr Thr Arg Val Ala Glu 360 365 370 gtc atc acc caa gtg gga ctg agc ccc gat gtc tta gat cgc tac ccc 1267 Val Ile Thr Gln Val Gly Leu Ser Pro Asp Val Leu Asp Arg Tyr Pro 375 380 385 cac gaa ttc tcc gga gga cag cgc caa cga atc tcc atc gcc aga gcc 1315 His Glu Phe Ser Gly Gly Gln Arg Gln Arg Ile Ser Ile Ala Arg Ala 390 395 400 405 ctc gcc atc aaa cca gcg atc ctg ctt gcc gac gaa cct gtc tcc gcc 1363 Leu Ala Ile Lys Pro Ala Ile Leu Leu Ala Asp Glu Pro Val Ser Ala 410 415 420 ctc gat gtg tcc gta cgt aaa caa gta ctg gat ctt ctc caa caa ctc 1411 Leu Asp Val Ser Val Arg Lys Gln Val Leu Asp Leu Leu Gln Gln Leu 425 430 435 gtc gaa gaa tac ggc atc acc ttg gtg ttc gtc tcc cac gat ctg gca 1459 Val Glu Glu Tyr Gly Ile Thr Leu Val Phe Val Ser His Asp Leu Ala 440 445 450 gtg gtg aga cac ctg tgc aca acc gtg tgg gtg atg gaa cag gga cga 1507 Val Val Arg His Leu Cys Thr Thr Val Trp Val Met Glu Gln Gly Arg 455 460 465 gtc ctt gag caa ggg ccc atc gat tcg gtt tat gat cac cca cag acc 1555 Val Leu Glu Gln Gly Pro Ile Asp Ser Val Tyr Asp His Pro Gln Thr 470 475 480 485 gaa tac acc aag gag ctg ctt gat gcc gtt ccg cgg ttg agc ctt 1600 Glu Tyr Thr Lys Glu Leu Leu Asp Ala Val Pro Arg Leu Ser Leu 490 495 500 taaaccagcg cagatgacaa cgcaatggtg 1630 <210> 164 <211> 500 <212> PRT <213> Corynebacterium glutamicum <400> 164 Leu Val Leu Ile Phe Ser Val Met Val Tyr Ala Met Pro Ser Ile Gln 1 5 10 15 Ser Gly Arg Ser Ala Val Leu Lys Val Ser Asp Leu Thr Val Gly Asn 20 25 30 Asn Phe Val His Asn Val Ser Phe Glu Val Asn Pro Gly Glu Arg Val 35 40 45 Gly Ile Ile Gly Glu Ser Gly Ser Gly Lys Ser Leu Thr Ala Leu Ser 50 55 60 Ile Met Gly Leu Thr Asp Leu Pro Thr Thr Gly Gln Ile Thr Phe Asn 65 70 75 80 Gly Lys Pro Ser Ala Thr Phe Arg Gly Thr Arg Ile Ala Met Val Phe 85 90 95 Gln Glu Pro Met Ser Ala Leu Asn Pro Leu Met Arg Ile Gly Arg Gln 100 105 110 Ile Glu Glu Met Met Thr Leu His Gly Ala Ser Lys Lys Asp Ala Arg 115 120 125 Ala Arg Leu Lys Ser Leu Leu Ile Asp Val Ser Leu Pro Glu Arg Thr 130 135 140 Ala Ser Ala Tyr Pro His Glu Leu Ser Gly Gly Gln Arg Gln Arg Ala 145 150 155 160 Leu Ile Ala Met Ala Leu Ala Asn Asp Pro Asp Leu Leu Ile Cys Asp 165 170 175 Glu Pro Thr Thr Ala Leu Asp Val Val Val Gln Lys Gln Ile Val Asp 180 185 190 Leu Leu Leu Arg Leu Thr Lys Glu Arg Gly Thr Ala Leu Leu Phe Ile 195 200 205 Thr His Asp Leu Gly Leu Ile Ala Arg Thr Cys Glu Arg Leu Leu Val 210 215 220 Met Lys Ser Gly Glu Thr Val Glu Arg Gly Asp Thr Glu Ala Ile Leu 225 230 235 240 Arg Ser Pro Ala His Ser Tyr Thr Gln Gln Leu Leu Asp Ala Ser Ile 245 250 255 Leu Asp Gln Pro Glu Ile Ala Ser Asp Ser Gly Ala Pro Val Val Ile 260 265 270 Asp Val Glu Glu Ala Ser Lys Ser Phe Lys Glu Thr Thr Ala Leu His 275 280 285 Lys Val Ser Leu Ala Val Arg Lys Gly Asp Leu Leu Gly Ile Val Gly 290 295 300 Gly Ser Gly Ser Gly Lys Thr Thr Leu Leu Lys Leu Ile Ala Gly Leu 305 310 315 320 Asp Lys Pro Thr Thr Gly Thr Val Ala Val Thr Gly Gly Val Gln Met 325 330 335 Val Phe Gln Asp Pro Gln Ser Ser Leu Asn Pro Arg Met Lys Ile Lys 340 345 350 Asp Ile Val Ala Glu Pro Leu Leu Gly Trp Asn Ala Ala Glu Lys Thr 355 360 365 Thr Arg Val Ala Glu Val Ile Thr Gln Val Gly Leu Ser Pro Asp Val 370 375 380 Leu Asp Arg Tyr Pro His Glu Phe Ser Gly Gly Gln Arg Gln Arg Ile 385 390 395 400 Ser Ile Ala Arg Ala Leu Ala Ile Lys Pro Ala Ile Leu Leu Ala Asp 405 410 415 Glu Pro Val Ser Ala Leu Asp Val Ser Val Arg Lys Gln Val Leu Asp 420 425 430 Leu Leu Gln Gln Leu Val Glu Glu Tyr Gly Ile Thr Leu Val Phe Val 435 440 445 Ser His Asp Leu Ala Val Val Arg His Leu Cys Thr Thr Val Trp Val 450 455 460 Met Glu Gln Gly Arg Val Leu Glu Gln Gly Pro Ile Asp Ser Val Tyr 465 470 475 480 Asp His Pro Gln Thr Glu Tyr Thr Lys Glu Leu Leu Asp Ala Val Pro 485 490 495 Arg Leu Ser Leu 500 <210> 165 <211> 1210 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1180) <223> RXA02922 <400> 165 cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc caccgccact attgatctca 60 gttccatatc cgcccaacta gtttcccagg gagcccactc atg atc tca ccg caa 115 Met Ile Ser Pro Gln 1 5 aca atc atc gac aat ctt gct cca gtc ctc gcg gag atc gca gca acg 163 Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala Glu Ile Ala Ala Thr 10 15 20 gct gcg cag cgc gaa cag gat cga gaa ttc agc cgt gat ttg gca aag 211 Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser Arg Asp Leu Ala Lys 25 30 35 cag ctt agt gcc ggt ggg ttc act aaa ctc cgc att cca gtt gaa ttt 259 Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg Ile Pro Val Glu Phe 40 45 50 ggc ggt ttg ggt ttt agc ctt cca gaa gca ttt gag gtg ctg gtg gca 307 Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe Glu Val Leu Val Ala 55 60 65 gcg gcc gct gca gat tca aat atc gcg cag gga ttg cgg cct cac ttc 355 Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly Leu Arg Pro His Phe 70 75 80 85 ttg gca gtg gag agc tta ttg atc gct cct tat tca gag cac cgc acc 403 Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr Ser Glu His Arg Thr 90 95 100 aag tgg ctg cga aaa atc gct gag aaa ggc gtg gtc att ggc aat gcg 451 Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val Val Ile Gly Asn Ala 105 110 115 ttg act gaa gtg gga aac aag cca ggt gag ctg aaa acc aag atc cga 499 Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu Lys Thr Lys Ile Arg 120 125 130 aag gaa ggc gag tct tac gtt ctc agc gac acc aag ttc tat tcc acg 547 Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr Lys Phe Tyr Ser Thr 135 140 145 ggc agt ctt tac gcc gac tgg att caa gta cat gcg aaa gat gag gaa 595 Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His Ala Lys Asp Glu Glu 150 155 160 165 gat caa gat gtt ttc gcc ttt gtt gat cgc gac gca tca ggc gtt gtt 643 Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp Ala Ser Gly Val Val 170 175 180 ttg gtg gat tac tgg gac gaa ttt ggg caa caa cta ttt gcc tcc gga 691 Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln Leu Phe Ala Ser Gly 185 190 195 acc agc ttc ttt gaa aaa gtc gtg gta gat cca ctg gac att gtc acc 739 Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro Leu Asp Ile Val Thr 200 205 210 cgt gat tac acc gca ccc agc gct ttc cag gcg ctg gcg cag tca cat 787 Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala Leu Ala Gln Ser His 215 220 225 cat ttg tct acg ttg act ggt att tcg cag gca atc acc cgt gac att 835 His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala Ile Thr Arg Asp Ile 230 235 240 245 gtt acc tat gta caa aac cgc acc cgt att ttc agc cac gga agt ggt 883 Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe Ser His Gly Ser Gly 250 255 260 gac ctt cca cgc ttt gat ccg cag gtg caa cag gtg gtg ggt gag gtg 931 Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln Val Val Gly Glu Val 265 270 275 aaa gcc aag tcg tat gca gtc gag aaa atc ttt cag ggt ttc gca caa 979 Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe Gln Gly Phe Ala Gln 280 285 290 gaa ctg gat ctt gtc gtc gat aag gca aaa gcc ggc act gct acg gag 1027 Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Ala Thr Glu 295 300 305 gtc gat ctg gcc gct gtc gac ctg agc gcc tac caa gcc cag tta gcg 1075 Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gln Ala Gln Leu Ala 310 315 320 325 gtg gca cct ttg gtg ctg agc cag gcc acc cag gcc ttt gag gtt ggc 1123 Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln Ala Phe Glu Val Gly 330 335 340 gca gat gcc tta aac ggc ggc cac gtg gct gcc caa tac acg atc gga 1171 Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala Gln Tyr Thr Ile Gly 345 350 355 tcc ttg tca tgagccaaga aattttgagc cattttgcac 1210 Ser Leu Ser 360 <210> 166 <211> 360 <212> PRT <213> Corynebacterium glutamicum <400> 166 Met Ile Ser Pro Gln Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala 1 5 10 15 Glu Ile Ala Ala Thr Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser 20 25 30 Arg Asp Leu Ala Lys Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg 35 40 45 Ile Pro Val Glu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe 50 55 60 Glu Val Leu Val Ala Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly 65 70 75 80 Leu Arg Pro His Phe Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr 85 90 95 Ser Glu His Arg Thr Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val 100 105 110 Val Ile Gly Asn Ala Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu 115 120 125 Lys Thr Lys Ile Arg Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr 130 135 140 Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His 145 150 155 160 Ala Lys Asp Glu Glu Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp 165 170 175 Ala Ser Gly Val Val Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln 180 185 190 Leu Phe Ala Ser Gly Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro 195 200 205 Leu Asp Ile Val Thr Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala 210 215 220 Leu Ala Gln Ser His His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala 225 230 235 240 Ile Thr Arg Asp Ile Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe 245 250 255 Ser His Gly Ser Gly Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln 260 265 270 Val Val Gly Glu Val Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe 275 280 285 Gln Gly Phe Ala Gln Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala 290 295 300 Gly Thr Ala Thr Glu Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr 305 310 315 320 Gln Ala Gln Leu Ala Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln 325 330 335 Ala Phe Glu Val Gly Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala 340 345 350 Gln Tyr Thr Ile Gly Ser Leu Ser 355 360 <210> 167 <211> 2365 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2335) <223> RXA02925 <400> 167 cgggttccgt gcccctggaa accgtccacc gggcaattga ggagaccggc tacaccgtct 60 tgtcctgatc gattcaccca tcatctcgac cccgaccggg ttg agc gga agg aac 115 Leu Ser Gly Arg Asn 1 5 ctc atg agc act ccc cac cac cac ggt gat cac ccc gct ccg gaa aca 163 Leu Met Ser Thr Pro His His His Gly Asp His Pro Ala Pro Glu Thr 10 15 20 gac cac acc cac cac ccg aat cat gcc ggt cac gag cac cat gcg gat 211 Asp His Thr His His Pro Asn His Ala Gly His Glu His His Ala Asp 25 30 35 gcc gcc acc cac ggc cag gcc atg ccg cac gat cat ccg cat tcc act 259 Ala Ala Thr His Gly Gln Ala Met Pro His Asp His Pro His Ser Thr 40 45 50 gtc gat gaa gaa cat cag gtc cac agt cac ggt gaa cac gcc ggc cac 307 Val Asp Glu Glu His Gln Val His Ser His Gly Glu His Ala Gly His 55 60 65 agc gcc gcg atg ttc cgg gac cgc ttc tgg tgg tcg ctg atc ctg tcg 355 Ser Ala Ala Met Phe Arg Asp Arg Phe Trp Trp Ser Leu Ile Leu Ser 70 75 80 85 gtt ccg gtg gtg ttc ttc agc ccg atg ttc gcc gac ctg ctg gga tat 403 Val Pro Val Val Phe Phe Ser Pro Met Phe Ala Asp Leu Leu Gly Tyr 90 95 100 aat att ccg gag att ccg gga gcc tac tgg att cct ccg gtc ctg ggc 451 Asn Ile Pro Glu Ile Pro Gly Ala Tyr Trp Ile Pro Pro Val Leu Gly 105 110 115 acg atc atc ttc ctc tac ggc ggc acc ccc ttc ctc aag ggc gca atg 499 Thr Ile Ile Phe Leu Tyr Gly Gly Thr Pro Phe Leu Lys Gly Ala Met 120 125 130 acc gag ctg aaa tcc cgc caa ccg ggc atg atg ctc ctg atc gcc atg 547 Thr Glu Leu Lys Ser Arg Gln Pro Gly Met Met Leu Leu Ile Ala Met 135 140 145 gcg atc acc gtg gcg ttt atc gcc tcc tgg gtc acc acc ctg ggg ctg 595 Ala Ile Thr Val Ala Phe Ile Ala Ser Trp Val Thr Thr Leu Gly Leu 150 155 160 165 ggc ggg ttc cac cta gat ttc tgg tgg gaa ctg gcc ctg ctg gtg acc 643 Gly Gly Phe His Leu Asp Phe Trp Trp Glu Leu Ala Leu Leu Val Thr 170 175 180 atc atg ctg ttg ggc cac tgg ctg gag atg cgc gct ctt ggt gca gcc 691 Ile Met Leu Leu Gly His Trp Leu Glu Met Arg Ala Leu Gly Ala Ala 185 190 195 tcc tcc gcg ctt gac gcg ctg gca gcg ctc ctg ccc gat gag gcc gag 739 Ser Ser Ala Leu Asp Ala Leu Ala Ala Leu Leu Pro Asp Glu Ala Glu 200 205 210 aag gtc gtc gac ggg acc acc cgc acc gta gcg atc tca gag ctg gcc 787 Lys Val Val Asp Gly Thr Thr Arg Thr Val Ala Ile Ser Glu Leu Ala 215 220 225 gtc gac gat gtc gtg ctg gtc cga gca ggt gcc cgc gtc ccg gcc gac 835 Val Asp Asp Val Val Leu Val Arg Ala Gly Ala Arg Val Pro Ala Asp 230 235 240 245 ggg acc atc atc gac gga gcg gcc gaa ttc gat gag gcc atg atc acc 883 Gly Thr Ile Ile Asp Gly Ala Ala Glu Phe Asp Glu Ala Met Ile Thr 250 255 260 ggc gaa tcc cga ccc gtc tac cgg gat acc ggt gag acc gtg gtg gcc 931 Gly Glu Ser Arg Pro Val Tyr Arg Asp Thr Gly Glu Thr Val Val Ala 265 270 275 ggc acc gtg gcc acc gac aac acc gtc cgt atc cgg gtg gag gcc acc 979 Gly Thr Val Ala Thr Asp Asn Thr Val Arg Ile Arg Val Glu Ala Thr 280 285 290 ggt ggg gac acc gcc ctg gca ggc atc cag cgc atg gtc gcc gac gcc 1027 Gly Gly Asp Thr Ala Leu Ala Gly Ile Gln Arg Met Val Ala Asp Ala 295 300 305 cag gcc tcc tcc tcc cgg gcc cag gcc ctg gcc gat cga gcc gca gcc 1075 Gln Ala Ser Ser Ser Arg Ala Gln Ala Leu Ala Asp Arg Ala Ala Ala 310 315 320 325 ttc ctg ttc tgg ttc gcc ctg atc acg gcc ctg atc acc gcc gtg gtc 1123 Phe Leu Phe Trp Phe Ala Leu Ile Thr Ala Leu Ile Thr Ala Val Val 330 335 340 tgg acc atc atc ggc agc ccc gac gat gcc gtg gtc cgc gcg gtg acc 1171 Trp Thr Ile Ile Gly Ser Pro Asp Asp Ala Val Val Arg Ala Val Thr 345 350 355 gtg ctg atc atc gcc tgc ccg cac gcc ctg ggc ctg gcc atc ccg ctg 1219 Val Leu Ile Ile Ala Cys Pro His Ala Leu Gly Leu Ala Ile Pro Leu 360 365 370 gtc atc gcg atc tcc tcc gag cgc gcc gcg aaa tcc ggg gtg ctc atc 1267 Val Ile Ala Ile Ser Ser Glu Arg Ala Ala Lys Ser Gly Val Leu Ile 375 380 385 aag gac cgc atg gca ctc gag cac atg cgc acc atc gac gtc gtc ttg 1315 Lys Asp Arg Met Ala Leu Glu His Met Arg Thr Ile Asp Val Val Leu 390 395 400 405 ttc gat aag acc ggc acc ctg acc gaa ggc gca cac gcc gtc acc ggc 1363 Phe Asp Lys Thr Gly Thr Leu Thr Glu Gly Ala His Ala Val Thr Gly 410 415 420 gtg gct ccg gcc acg ggt atc gcc gag ggt gag ctg ctg gcc ctg gcc 1411 Val Ala Pro Ala Thr Gly Ile Ala Glu Gly Glu Leu Leu Ala Leu Ala 425 430 435 gcc gcc gct gag gcc gat agt gag cac ccc gtg gcc cgc gcg atc gtg 1459 Ala Ala Ala Glu Ala Asp Ser Glu His Pro Val Ala Arg Ala Ile Val 440 445 450 act gcc gcg gcc gca cac ccg gag gcc tcg cag cgt cag ctg cgc gca 1507 Thr Ala Ala Ala Ala His Pro Glu Ala Ser Gln Arg Gln Leu Arg Ala 455 460 465 acc ggt ttc acc gcc gcc tcc ggc cgc ggg atc cgg gcc acc gtc gac 1555 Thr Gly Phe Thr Ala Ala Ser Gly Arg Gly Ile Arg Ala Thr Val Asp 470 475 480 485 ggt gcc gaa atc ctc gtg ggc ggg ccg aac atg cta cgc gag ttc aat 1603 Gly Ala Glu Ile Leu Val Gly Gly Pro Asn Met Leu Arg Glu Phe Asn 490 495 500 ctg acc acc ccg ggt gag ctc gcc gac atc acc ggt tcc tgg gca cag 1651 Leu Thr Thr Pro Gly Glu Leu Ala Asp Ile Thr Gly Ser Trp Ala Gln 505 510 515 cga ggt gcc gga gtg ctc cat gtc gtc cgc gac ggt gag atc atc ggt 1699 Arg Gly Ala Gly Val Leu His Val Val Arg Asp Gly Glu Ile Ile Gly 520 525 530 gcg gtg gca gtg gag gac aaa atc cgc ccc gaa tcc cgc gcg gcg gta 1747 Ala Val Ala Val Glu Asp Lys Ile Arg Pro Glu Ser Arg Ala Ala Val 535 540 545 cgc gcc ctg cag gcc cgc ggg gtg aag gtg gcg atg atc acc ggt gac 1795 Arg Ala Leu Gln Ala Arg Gly Val Lys Val Ala Met Ile Thr Gly Asp 550 555 560 565 gcc acc cag gtc gcc cag gca gtg ggc aag gat ctg ggg atc gat gag 1843 Ala Thr Gln Val Ala Gln Ala Val Gly Lys Asp Leu Gly Ile Asp Glu 570 575 580 gtc ttc gcc gag gtt ctg ccg cag gac aag gac acc aag gtc acc cag 1891 Val Phe Ala Glu Val Leu Pro Gln Asp Lys Asp Thr Lys Val Thr Gln 585 590 595 ctg cag gag cgc ggt ctg agc gtg gcc atg gtc ggc gac ggt gtc aat 1939 Leu Gln Glu Arg Gly Leu Ser Val Ala Met Val Gly Asp Gly Val Asn 600 605 610 gac gcc ccg gcc ctg gcc cgg gcc gag gtc ggt att gcg att ggc gcg 1987 Asp Ala Pro Ala Leu Ala Arg Ala Glu Val Gly Ile Ala Ile Gly Ala 615 620 625 ggt aca gat gtg gcg atg gag tcc gcc ggg gtg gtc ctg gcc agt gat 2035 Gly Thr Asp Val Ala Met Glu Ser Ala Gly Val Val Leu Ala Ser Asp 630 635 640 645 gat ccc cgg gcc gtg ctg tcg atg atc gag ctc tcc cat gcc agc tac 2083 Asp Pro Arg Ala Val Leu Ser Met Ile Glu Leu Ser His Ala Ser Tyr 650 655 660 cgc aag atg gtc cag aac ctg gtc tgg gcg acc ggg tac aac atc gtg 2131 Arg Lys Met Val Gln Asn Leu Val Trp Ala Thr Gly Tyr Asn Ile Val 665 670 675 gcc gtt ccg ctg gcc gcc ggt gtg ctc gcc cct atc ggt gtg ctg ctt 2179 Ala Val Pro Leu Ala Ala Gly Val Leu Ala Pro Ile Gly Val Leu Leu 680 685 690 ccc ccg gcg gcg gcc gcc atc ttg atg tcc ctg tcc acg atc atc gtc 2227 Pro Pro Ala Ala Ala Ala Ile Leu Met Ser Leu Ser Thr Ile Ile Val 695 700 705 gcc ctc aac gcc cag ctg cta cgc cgg atc gac ctg gac ccg gct cac 2275 Ala Leu Asn Ala Gln Leu Leu Arg Arg Ile Asp Leu Asp Pro Ala His 710 715 720 725 cta gct ccg acc gac ggg aag gag gag aag gct gct gtg agc tct gca 2323 Leu Ala Pro Thr Asp Gly Lys Glu Glu Lys Ala Ala Val Ser Ser Ala 730 735 740 gcc ccc gtc cgc tgactttcaa tgcttcatgg actcccccat 2365 Ala Pro Val Arg 745 <210> 168 <211> 745 <212> PRT <213> Corynebacterium glutamicum <400> 168 Leu Ser Gly Arg Asn Leu Met Ser Thr Pro His His His Gly Asp His 1 5 10 15 Pro Ala Pro Glu Thr Asp His Thr His His Pro Asn His Ala Gly His 20 25 30 Glu His His Ala Asp Ala Ala Thr His Gly Gln Ala Met Pro His Asp 35 40 45 His Pro His Ser Thr Val Asp Glu Glu His Gln Val His Ser His Gly 50 55 60 Glu His Ala Gly His Ser Ala Ala Met Phe Arg Asp Arg Phe Trp Trp 65 70 75 80 Ser Leu Ile Leu Ser Val Pro Val Val Phe Phe Ser Pro Met Phe Ala 85 90 95 Asp Leu Leu Gly Tyr Asn Ile Pro Glu Ile Pro Gly Ala Tyr Trp Ile 100 105 110 Pro Pro Val Leu Gly Thr Ile Ile Phe Leu Tyr Gly Gly Thr Pro Phe 115 120 125 Leu Lys Gly Ala Met Thr Glu Leu Lys Ser Arg Gln Pro Gly Met Met 130 135 140 Leu Leu Ile Ala Met Ala Ile Thr Val Ala Phe Ile Ala Ser Trp Val 145 150 155 160 Thr Thr Leu Gly Leu Gly Gly Phe His Leu Asp Phe Trp Trp Glu Leu 165 170 175 Ala Leu Leu Val Thr Ile Met Leu Leu Gly His Trp Leu Glu Met Arg 180 185 190 Ala Leu Gly Ala Ala Ser Ser Ala Leu Asp Ala Leu Ala Ala Leu Leu 195 200 205 Pro Asp Glu Ala Glu Lys Val Val Asp Gly Thr Thr Arg Thr Val Ala 210 215 220 Ile Ser Glu Leu Ala Val Asp Asp Val Val Leu Val Arg Ala Gly Ala 225 230 235 240 Arg Val Pro Ala Asp Gly Thr Ile Ile Asp Gly Ala Ala Glu Phe Asp 245 250 255 Glu Ala Met Ile Thr Gly Glu Ser Arg Pro Val Tyr Arg Asp Thr Gly 260 265 270 Glu Thr Val Val Ala Gly Thr Val Ala Thr Asp Asn Thr Val Arg Ile 275 280 285 Arg Val Glu Ala Thr Gly Gly Asp Thr Ala Leu Ala Gly Ile Gln Arg 290 295 300 Met Val Ala Asp Ala Gln Ala Ser Ser Ser Arg Ala Gln Ala Leu Ala 305 310 315 320 Asp Arg Ala Ala Ala Phe Leu Phe Trp Phe Ala Leu Ile Thr Ala Leu 325 330 335 Ile Thr Ala Val Val Trp Thr Ile Ile Gly Ser Pro Asp Asp Ala Val 340 345 350 Val Arg Ala Val Thr Val Leu Ile Ile Ala Cys Pro His Ala Leu Gly 355 360 365 Leu Ala Ile Pro Leu Val Ile Ala Ile Ser Ser Glu Arg Ala Ala Lys 370 375 380 Ser Gly Val Leu Ile Lys Asp Arg Met Ala Leu Glu His Met Arg Thr 385 390 395 400 Ile Asp Val Val Leu Phe Asp Lys Thr Gly Thr Leu Thr Glu Gly Ala 405 410 415 His Ala Val Thr Gly Val Ala Pro Ala Thr Gly Ile Ala Glu Gly Glu 420 425 430 Leu Leu Ala Leu Ala Ala Ala Ala Glu Ala Asp Ser Glu His Pro Val 435 440 445 Ala Arg Ala Ile Val Thr Ala Ala Ala Ala His Pro Glu Ala Ser Gln 450 455 460 Arg Gln Leu Arg Ala Thr Gly Phe Thr Ala Ala Ser Gly Arg Gly Ile 465 470 475 480 Arg Ala Thr Val Asp Gly Ala Glu Ile Leu Val Gly Gly Pro Asn Met 485 490 495 Leu Arg Glu Phe Asn Leu Thr Thr Pro Gly Glu Leu Ala Asp Ile Thr 500 505 510 Gly Ser Trp Ala Gln Arg Gly Ala Gly Val Leu His Val Val Arg Asp 515 520 525 Gly Glu Ile Ile Gly Ala Val Ala Val Glu Asp Lys Ile Arg Pro Glu 530 535 540 Ser Arg Ala Ala Val Arg Ala Leu Gln Ala Arg Gly Val Lys Val Ala 545 550 555 560 Met Ile Thr Gly Asp Ala Thr Gln Val Ala Gln Ala Val Gly Lys Asp 565 570 575 Leu Gly Ile Asp Glu Val Phe Ala Glu Val Leu Pro Gln Asp Lys Asp 580 585 590 Thr Lys Val Thr Gln Leu Gln Glu Arg Gly Leu Ser Val Ala Met Val 595 600 605 Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Ala Arg Ala Glu Val Gly 610 615 620 Ile Ala Ile Gly Ala Gly Thr Asp Val Ala Met Glu Ser Ala Gly Val 625 630 635 640 Val Leu Ala Ser Asp Asp Pro Arg Ala Val Leu Ser Met Ile Glu Leu 645 650 655 Ser His Ala Ser Tyr Arg Lys Met Val Gln Asn Leu Val Trp Ala Thr 660 665 670 Gly Tyr Asn Ile Val Ala Val Pro Leu Ala Ala Gly Val Leu Ala Pro 675 680 685 Ile Gly Val Leu Leu Pro Pro Ala Ala Ala Ala Ile Leu Met Ser Leu 690 695 700 Ser Thr Ile Ile Val Ala Leu Asn Ala Gln Leu Leu Arg Arg Ile Asp 705 710 715 720 Leu Asp Pro Ala His Leu Ala Pro Thr Asp Gly Lys Glu Glu Lys Ala 725 730 735 Ala Val Ser Ser Ala Ala Pro Val Arg 740 745 <210> 169 <211> 1075 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1045) <223> RXA02991 <400> 169 ttgtcgtgtt cgcgatcttc gccgttggct tcatgattct gaccctgcct atgggccttg 60 gcttgggcaa actctctgag cgtttggcgg tgaagaagta atg gct aat aca gtt 115 Met Ala Asn Thr Val 1 5 cgc gca aca gtc ctc tac gat gct cct gga cca aag ggc cgt cga ttc 163 Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro Lys Gly Arg Arg Phe 10 15 20 aac ctc ata atc acc att ctc acg gtg gtt ctg gga ttg gcg ctc ctc 211 Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu Gly Leu Ala Leu Leu 25 30 35 ttc tgg att ggc tcc atg ctt tca ggc aac ggc caa ctc gat gcc aac 259 Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly Gln Leu Asp Ala Asn 40 45 50 aaa tgg act ccg ttc atc aat tcc caa acc tgg acc acc tac att ctt 307 Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp Thr Thr Tyr Ile Leu 55 60 65 cct ggt ttg tgg ggc acg ctg aaa tct gcc gtg ttc tcg gtg atc ttg 355 Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val Phe Ser Val Ile Leu 70 75 80 85 gct ctg gtc atg ggt acc gca ctg ggt ctt ggc cgt atc tct gaa atc 403 Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly Arg Ile Ser Glu Ile 90 95 100 agg att ctc cgc tgg ttc tgc gcc gtc atc atc gag act ttc cga gcc 451 Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile Glu Thr Phe Arg Ala 105 110 115 att ccg gtt ctg atc ctc atg att ttc gcc tac cag atg ttc gcc cag 499 Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr Gln Met Phe Ala Gln 120 125 130 tac aac atc gtg ccg tcg agc cag ctc gcg ttc gcc gcc gtg gta ttc 547 Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe 135 140 145 ggt ctg acc atg tac aac ggt tct gtg atc gca gag att ctg cgt tct 595 Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala Glu Ile Leu Arg Ser 150 155 160 165 ggt atc gct tcc ctg cct aag ggg cag aag gaa gca gcg att gcg ttg 643 Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu Ala Ala Ile Ala Leu 170 175 180 ggt atg tct tct agg caa acc acc tgg tca atc ttg ttg cct cag gcc 691 Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile Leu Leu Pro Gln Ala 185 190 195 gtg gct gca atg ctc cca gcg ttg atc tct cag atg gtt att gca ctg 739 Val Ala Ala Met Leu Pro Ala Leu Ile Ser Gln Met Val Ile Ala Leu 200 205 210 aag gac tcc gca ctt ggt tac cag atc ggc tac att gaa gtg gtt cgt 787 Lys Asp Ser Ala Leu Gly Tyr Gln Ile Gly Tyr Ile Glu Val Val Arg 215 220 225 tcc ggt att cag tcc gcg tct gtc aac cgc aac tac ctt gca gcg ctg 835 Ser Gly Ile Gln Ser Ala Ser Val Asn Arg Asn Tyr Leu Ala Ala Leu 230 235 240 245 ttt gtt gtt gcg ctg atc atg att gtt ctg aac ttc tcc ctc acc gct 883 Phe Val Val Ala Leu Ile Met Ile Val Leu Asn Phe Ser Leu Thr Ala 250 255 260 ctg gct tct cgc atc gag cgc cag ttg cgt gca ggt agg gct cgt aag 931 Leu Ala Ser Arg Ile Glu Arg Gln Leu Arg Ala Gly Arg Ala Arg Lys 265 270 275 aac att gtt gcc aag gtc cct gag cag cca gat caa ggt ctg gag acc 979 Asn Ile Val Ala Lys Val Pro Glu Gln Pro Asp Gln Gly Leu Glu Thr 280 285 290 aag gac aat gtc aat gtc gac tgg cag gat cct gat tat aag gat ctg 1027 Lys Asp Asn Val Asn Val Asp Trp Gln Asp Pro Asp Tyr Lys Asp Leu 295 300 305 aaa acc cct gga gtt cag taactccctt accccggatg attcccatcc 1075 Lys Thr Pro Gly Val Gln 310 315 <210> 170 <211> 315 <212> PRT <213> Corynebacterium glutamicum <400> 170 Met Ala Asn Thr Val Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro 1 5 10 15 Lys Gly Arg Arg Phe Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu 20 25 30 Gly Leu Ala Leu Leu Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly 35 40 45 Gln Leu Asp Ala Asn Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp 50 55 60 Thr Thr Tyr Ile Leu Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val 65 70 75 80 Phe Ser Val Ile Leu Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly 85 90 95 Arg Ile Ser Glu Ile Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile 100 105 110 Glu Thr Phe Arg Ala Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr 115 120 125 Gln Met Phe Ala Gln Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe 130 135 140 Ala Ala Val Val Phe Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala 145 150 155 160 Glu Ile Leu Arg Ser Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu 165 170 175 Ala Ala Ile Ala Leu Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile 180 185 190 Leu Leu Pro Gln Ala Val Ala Ala Met Leu Pro Ala Leu Ile Ser Gln 195 200 205 Met Val Ile Ala Leu Lys Asp Ser Ala Leu Gly Tyr Gln Ile Gly Tyr 210 215 220 Ile Glu Val Val Arg Ser Gly Ile Gln Ser Ala Ser Val Asn Arg Asn 225 230 235 240 Tyr Leu Ala Ala Leu Phe Val Val Ala Leu Ile Met Ile Val Leu Asn 245 250 255 Phe Ser Leu Thr Ala Leu Ala Ser Arg Ile Glu Arg Gln Leu Arg Ala 260 265 270 Gly Arg Ala Arg Lys Asn Ile Val Ala Lys Val Pro Glu Gln Pro Asp 275 280 285 Gln Gly Leu Glu Thr Lys Asp Asn Val Asn Val Asp Trp Gln Asp Pro 290 295 300 Asp Tyr Lys Asp Leu Lys Thr Pro Gly Val Gln 305 310 315 <210> 171 <211> 1354 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1324) <223> RXA03129 <400> 171 gctgaggttg agaccaagct gaacaccatc tacacccgcg acatcgaacc acttatttaa 60 tccgagcact tcagctacac ctatttaagg aggctgtgac atg gcg tca atc gtc 115 Met Ala Ser Ile Val 1 5 ttt gaa aac gtc aca cgc aaa tac tct ccg ggc gca cgc ccg gcc gtc 163 Phe Glu Asn Val Thr Arg Lys Tyr Ser Pro Gly Ala Arg Pro Ala Val 10 15 20 gac aag ctt aat ttg gaa atc gcc gac ggc gag ttc cta gtt ctc gtt 211 Asp Lys Leu Asn Leu Glu Ile Ala Asp Gly Glu Phe Leu Val Leu Val 25 30 35 gga ccc tca ggc tgt gga aag tcc act tct ttg cgc atg ctg gct ggt 259 Gly Pro Ser Gly Cys Gly Lys Ser Thr Ser Leu Arg Met Leu Ala Gly 40 45 50 ctt gag cct atc gac gag gga cgt cta ctc att gat ggt aaa gac gcc 307 Leu Glu Pro Ile Asp Glu Gly Arg Leu Leu Ile Asp Gly Lys Asp Ala 55 60 65 acg gaa ctg cgt ccg cag gat cgt gac atc gct atg gtc ttc cag agc 355 Thr Glu Leu Arg Pro Gln Asp Arg Asp Ile Ala Met Val Phe Gln Ser 70 75 80 85 tac gcg ctg tac ccg aat atg act gtt cgg gac aac atg ggc ttt gcg 403 Tyr Ala Leu Tyr Pro Asn Met Thr Val Arg Asp Asn Met Gly Phe Ala 90 95 100 ctg aag aat cag aag gtg gct aag gct gag atc gaa aag cgt gtt gct 451 Leu Lys Asn Gln Lys Val Ala Lys Ala Glu Ile Glu Lys Arg Val Ala 105 110 115 gaa gcc tca cgc att ctg cag ctg gat ccg tat ctt gat cgt aag cct 499 Glu Ala Ser Arg Ile Leu Gln Leu Asp Pro Tyr Leu Asp Arg Lys Pro 120 125 130 gca gct ttg tct ggt ggt cag cgc cag cgc gtg gcc atg ggc cgt gca 547 Ala Ala Leu Ser Gly Gly Gln Arg Gln Arg Val Ala Met Gly Arg Ala 135 140 145 att gtg cgt gag cca tcg gtg ttc tgc atg gat gag cca ctg tcc aac 595 Ile Val Arg Glu Pro Ser Val Phe Cys Met Asp Glu Pro Leu Ser Asn 150 155 160 165 cta gat gcg aag ctg cgt gtg tct acg cgt gcg gag atc tct ggt ttg 643 Leu Asp Ala Lys Leu Arg Val Ser Thr Arg Ala Glu Ile Ser Gly Leu 170 175 180 cag cgt cgc atg ggc gtg acc acg gtg tat gtg act cac gat cag gtc 691 Gln Arg Arg Met Gly Val Thr Thr Val Tyr Val Thr His Asp Gln Val 185 190 195 gag gcc atg acc atg ggt gat cgc gtc gct gtg ctt ttg ctc ggt gtg 739 Glu Ala Met Thr Met Gly Asp Arg Val Ala Val Leu Leu Leu Gly Val 200 205 210 ctg cag caa gta gac acc ccg cag aac ctg tac gac tac cca gca aat 787 Leu Gln Gln Val Asp Thr Pro Gln Asn Leu Tyr Asp Tyr Pro Ala Asn 215 220 225 gcg ttc gtc gcc agc ttc att ggt tcc cct tcc atg aac ttg att gag 835 Ala Phe Val Ala Ser Phe Ile Gly Ser Pro Ser Met Asn Leu Ile Glu 230 235 240 245 ggc acc atc cgt ggc gat aag gtc act ttg ggt act gga att cag att 883 Gly Thr Ile Arg Gly Asp Lys Val Thr Leu Gly Thr Gly Ile Gln Ile 250 255 260 tca gtt cct gat gag gtg gca gca gag gtt cgc aac aac ccg gat cgc 931 Ser Val Pro Asp Glu Val Ala Ala Glu Val Arg Asn Asn Pro Asp Arg 265 270 275 ttt gag ggt cgt cca gtc att gtt ggt gct cgt ccc gag cac atg tat 979 Phe Glu Gly Arg Pro Val Ile Val Gly Ala Arg Pro Glu His Met Tyr 280 285 290 ttg acc acg gcg aat gag agt ggt gct gta ttg ggc gaa gtc agc cac 1027 Leu Thr Thr Ala Asn Glu Ser Gly Ala Val Leu Gly Glu Val Ser His 295 300 305 att gat gag ctc ggc gcg gat tca atg gtc tac gta ttg gcg tct ggt 1075 Ile Asp Glu Leu Gly Ala Asp Ser Met Val Tyr Val Leu Ala Ser Gly 310 315 320 325 gtg aag aac ccg aat act gat ctt ttg ggt gag ggc att cca gag gat 1123 Val Lys Asn Pro Asn Thr Asp Leu Leu Gly Glu Gly Ile Pro Glu Asp 330 335 340 atg cgc gtg acc gtt gtc ggt gct gaa gag acc gat aag gcc cgg ctg 1171 Met Arg Val Thr Val Val Gly Ala Glu Glu Thr Asp Lys Ala Arg Leu 345 350 355 ggt att cgt gtt gag cgc cat cac ggt ctg aag gcc ggc gat aag gtg 1219 Gly Ile Arg Val Glu Arg His His Gly Leu Lys Ala Gly Asp Lys Val 360 365 370 cac gtt gtt gct gca ccg aag gat gtt cac ctc ttc gac ggt ctt gat 1267 His Val Val Ala Ala Pro Lys Asp Val His Leu Phe Asp Gly Leu Asp 375 380 385 ggc cgt cga atc ggt gca acg gtt cta gct cca gcc cat aca gtc cag 1315 Gly Arg Arg Ile Gly Ala Thr Val Leu Ala Pro Ala His Thr Val Gln 390 395 400 405 gct ggt cac tagattattt accagtgcaa ctccccagca 1354 Ala Gly His <210> 172 <211> 408 <212> PRT <213> Corynebacterium glutamicum <400> 172 Met Ala Ser Ile Val Phe Glu Asn Val Thr Arg Lys Tyr Ser Pro Gly 1 5 10 15 Ala Arg Pro Ala Val Asp Lys Leu Asn Leu Glu Ile Ala Asp Gly Glu 20 25 30 Phe Leu Val Leu Val Gly Pro Ser Gly Cys Gly Lys Ser Thr Ser Leu 35 40 45 Arg Met Leu Ala Gly Leu Glu Pro Ile Asp Glu Gly Arg Leu Leu Ile 50 55 60 Asp Gly Lys Asp Ala Thr Glu Leu Arg Pro Gln Asp Arg Asp Ile Ala 65 70 75 80 Met Val Phe Gln Ser Tyr Ala Leu Tyr Pro Asn Met Thr Val Arg Asp 85 90 95 Asn Met Gly Phe Ala Leu Lys Asn Gln Lys Val Ala Lys Ala Glu Ile 100 105 110 Glu Lys Arg Val Ala Glu Ala Ser Arg Ile Leu Gln Leu Asp Pro Tyr 115 120 125 Leu Asp Arg Lys Pro Ala Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 130 135 140 Ala Met Gly Arg Ala Ile Val Arg Glu Pro Ser Val Phe Cys Met Asp 145 150 155 160 Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Ser Thr Arg Ala 165 170 175 Glu Ile Ser Gly Leu Gln Arg Arg Met Gly Val Thr Thr Val Tyr Val 180 185 190 Thr His Asp Gln Val Glu Ala Met Thr Met Gly Asp Arg Val Ala Val 195 200 205 Leu Leu Leu Gly Val Leu Gln Gln Val Asp Thr Pro Gln Asn Leu Tyr 210 215 220 Asp Tyr Pro Ala Asn Ala Phe Val Ala Ser Phe Ile Gly Ser Pro Ser 225 230 235 240 Met Asn Leu Ile Glu Gly Thr Ile Arg Gly Asp Lys Val Thr Leu Gly 245 250 255 Thr Gly Ile Gln Ile Ser Val Pro Asp Glu Val Ala Ala Glu Val Arg 260 265 270 Asn Asn Pro Asp Arg Phe Glu Gly Arg Pro Val Ile Val Gly Ala Arg 275 280 285 Pro Glu His Met Tyr Leu Thr Thr Ala Asn Glu Ser Gly Ala Val Leu 290 295 300 Gly Glu Val Ser His Ile Asp Glu Leu Gly Ala Asp Ser Met Val Tyr 305 310 315 320 Val Leu Ala Ser Gly Val Lys Asn Pro Asn Thr Asp Leu Leu Gly Glu 325 330 335 Gly Ile Pro Glu Asp Met Arg Val Thr Val Val Gly Ala Glu Glu Thr 340 345 350 Asp Lys Ala Arg Leu Gly Ile Arg Val Glu Arg His His Gly Leu Lys 355 360 365 Ala Gly Asp Lys Val His Val Val Ala Ala Pro Lys Asp Val His Leu 370 375 380 Phe Asp Gly Leu Asp Gly Arg Arg Ile Gly Ala Thr Val Leu Ala Pro 385 390 395 400 Ala His Thr Val Gln Ala Gly His 405 <210> 173 <211> 610 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(580) <223> RXA03157 <400> 173 ctggctggta cccaccaccc agaaacttaa aaaacgaacc tacggcatag cacgcatgga 60 catggccgtt ttcgacgaat ctctgcttca ggagtaacca atg aaa gct gtt tgc 115 Met Lys Ala Val Cys 1 5 cca gga tca ttc gac ccc atc acc ctc ggc cac ctc gac atc gtg acc 163 Pro Gly Ser Phe Asp Pro Ile Thr Leu Gly His Leu Asp Ile Val Thr 10 15 20 cgc gcc gcc gcg caa ttt agc gaa gtc acc atc ttg gtc acc gcc aac 211 Arg Ala Ala Ala Gln Phe Ser Glu Val Thr Ile Leu Val Thr Ala Asn 25 30 35 ccc aac aaa aac tca gga ctg ttc acc gtc gca gaa cgc atg gat ctc 259 Pro Asn Lys Asn Ser Gly Leu Phe Thr Val Ala Glu Arg Met Asp Leu 40 45 50 atc cgc gaa tcc acc gca cac ctc gac aac gta aaa gta gac acc tgg 307 Ile Arg Glu Ser Thr Ala His Leu Asp Asn Val Lys Val Asp Thr Trp 55 60 65 gcc tca ctg ctc gtg gat tac acc acc gaa cat ggc atc ggc gcc cta 355 Ala Ser Leu Leu Val Asp Tyr Thr Thr Glu His Gly Ile Gly Ala Leu 70 75 80 85 gtc aaa ggc ctg cga agc tcc ctc gac tac gaa tac gag ctc ccc atg 403 Val Lys Gly Leu Arg Ser Ser Leu Asp Tyr Glu Tyr Glu Leu Pro Met 90 95 100 gca cag atg aac agg cga ctc acg ggc gta gac acc ttc ttc ctc ctc 451 Ala Gln Met Asn Arg Arg Leu Thr Gly Val Asp Thr Phe Phe Leu Leu 105 110 115 acc gac gag aaa tac ggc tac gtc agc tcc aca ctg tgc aaa gaa gtt 499 Thr Asp Glu Lys Tyr Gly Tyr Val Ser Ser Thr Leu Cys Lys Glu Val 120 125 130 gcc cgc ttc ggt ggc gat gtc tcc ggc ctc cta cct gag gta gtg gca 547 Ala Arg Phe Gly Gly Asp Val Ser Gly Leu Leu Pro Glu Val Val Ala 135 140 145 aaa gcc gtg aca gaa aaa tac agc aac cag cac tagtttcttt tgcatcaagc 600 Lys Ala Val Thr Glu Lys Tyr Ser Asn Gln His 150 155 160 gtctagacta 610 <210> 174 <211> 160 <212> PRT <213> Corynebacterium glutamicum <400> 174 Met Lys Ala Val Cys Pro Gly Ser Phe Asp Pro Ile Thr Leu Gly His 1 5 10 15 Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val Thr Ile 20 25 30 Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr Val Ala 35 40 45 Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp Asn Val 50 55 60 Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr Glu His 65 70 75 80 Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp Tyr Glu 85 90 95 Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly Val Asp 100 105 110 Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser Ser Thr 115 120 125 Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly Leu Leu 130 135 140 Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn Gln His 145 150 155 160 <210> 175 <211> 2503 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2473) <223> RXA03285 <400> 175 tgtgcaaaat tgcattcagg ctgaaaaatt cctaaaggga ctccgtccga ataattggaa 60 agcccagaag aacagtcaac tcctagatta aaggataatc gtg gcg aaa ttc ctg 115 Val Ala Lys Phe Leu 1 5 tat aag tta ggc tcc acg gcc tat caa aag aaa tgg ccg ttt ctt gcg 163 Tyr Lys Leu Gly Ser Thr Ala Tyr Gln Lys Lys Trp Pro Phe Leu Ala 10 15 20 gtc tgg ctc gtg att ctc ata ggt atc acg acg ctg gcg ggg ctg tat 211 Val Trp Leu Val Ile Leu Ile Gly Ile Thr Thr Leu Ala Gly Leu Tyr 25 30 35 gcc aag cca acg tcg agt agc ttc tct atc cct ggt ctt gat tct gtc 259 Ala Lys Pro Thr Ser Ser Ser Phe Ser Ile Pro Gly Leu Asp Ser Val 40 45 50 acg acc atg gag aag atg cag gag cgt ttc cct ggt tcg gat gat gca 307 Thr Thr Met Glu Lys Met Gln Glu Arg Phe Pro Gly Ser Asp Asp Ala 55 60 65 aca tcg gct ccc act ggt tct gtc gtc att cag gca ccg gaa ggc aag 355 Thr Ser Ala Pro Thr Gly Ser Val Val Ile Gln Ala Pro Glu Gly Lys 70 75 80 85 acc ctc act gat cct gag gtt ggg gct gaa gta aac cag atg ctt gat 403 Thr Leu Thr Asp Pro Glu Val Gly Ala Glu Val Asn Gln Met Leu Asp 90 95 100 gag gtt cgg gcg act ggt gtg ctg aag gat gct gat tcc gtt gtg gat 451 Glu Val Arg Ala Thr Gly Val Leu Lys Asp Ala Asp Ser Val Val Asp 105 110 115 cct gtg ttg gct gcg cag ggt gtg gct gct cag atg acc cca gcc ctg 499 Pro Val Leu Ala Ala Gln Gly Val Ala Ala Gln Met Thr Pro Ala Leu 120 125 130 gag gct cag ggt gta cct gcg gag aag atc gcc gca gat att gag tcg 547 Glu Ala Gln Gly Val Pro Ala Glu Lys Ile Ala Ala Asp Ile Glu Ser 135 140 145 att agt cca ctg agt gca gat gag act acc ggc atc atc tcg atg act 595 Ile Ser Pro Leu Ser Ala Asp Glu Thr Thr Gly Ile Ile Ser Met Thr 150 155 160 165 ttt gat gca gat tct gcc atg gat ata tcc gca gag gat cgt gag aag 643 Phe Asp Ala Asp Ser Ala Met Asp Ile Ser Ala Glu Asp Arg Glu Lys 170 175 180 gtc acc aat att ctt gat gaa tac gat gac ggc gat ctg act gtt gtc 691 Val Thr Asn Ile Leu Asp Glu Tyr Asp Asp Gly Asp Leu Thr Val Val 185 190 195 tac aac ggc aac gtg ttt ggc gca gct gca acc agc ttg gac atg acc 739 Tyr Asn Gly Asn Val Phe Gly Ala Ala Ala Thr Ser Leu Asp Met Thr 200 205 210 tct gag ctc atc ggc ctg ctg gtg gct gcg gtc gtt ctt atc gtg acc 787 Ser Glu Leu Ile Gly Leu Leu Val Ala Ala Val Val Leu Ile Val Thr 215 220 225 ttc ggt tcg ttc atc gct gcc ggt atg ccg ctg atc tct gca atc att 835 Phe Gly Ser Phe Ile Ala Ala Gly Met Pro Leu Ile Ser Ala Ile Ile 230 235 240 245 ggt gtc gga atc ggc atc atg ggc att cag tta gcc acg gcg ttt act 883 Gly Val Gly Ile Gly Ile Met Gly Ile Gln Leu Ala Thr Ala Phe Thr 250 255 260 gat tcg gtc aat gac atg act cct acc ctg gcg tcg atg att ggt ctg 931 Asp Ser Val Asn Asp Met Thr Pro Thr Leu Ala Ser Met Ile Gly Leu 265 270 275 gct gtc ggt atc gac tac gcg cta ttt atc gtg tcc cgt ttc cgc aat 979 Ala Val Gly Ile Asp Tyr Ala Leu Phe Ile Val Ser Arg Phe Arg Asn 280 285 290 gag ttg att tct cag act ggc gct aat gat ctg gag cca aag gaa ttg 1027 Glu Leu Ile Ser Gln Thr Gly Ala Asn Asp Leu Glu Pro Lys Glu Leu 295 300 305 gct gag cgt ctg cgc acc atg ccg ttg gct gct cgt gcg cat gcg atg 1075 Ala Glu Arg Leu Arg Thr Met Pro Leu Ala Ala Arg Ala His Ala Met 310 315 320 325 gga atg gct gtg ggc act gcg ggt tct gcg gtt gta ttc gcg ggt acc 1123 Gly Met Ala Val Gly Thr Ala Gly Ser Ala Val Val Phe Ala Gly Thr 330 335 340 acg gtg ctg atc gct ctg gtt gct ctg tcg atc att aat att cca ttt 1171 Thr Val Leu Ile Ala Leu Val Ala Leu Ser Ile Ile Asn Ile Pro Phe 345 350 355 cta acc gtg atg gcc att gct gcc gca atc acc gtt gcc atc gca gtt 1219 Leu Thr Val Met Ala Ile Ala Ala Ala Ile Thr Val Ala Ile Ala Val 360 365 370 ctg gtt gct ctg tcc ttc ctc cca gct ctg ctt ggc ctg ctt ggc act 1267 Leu Val Ala Leu Ser Phe Leu Pro Ala Leu Leu Gly Leu Leu Gly Thr 375 380 385 cgc atc ttc gca gca cgc gtg cct gga cct aag gtt ccg gat cct gag 1315 Arg Ile Phe Ala Ala Arg Val Pro Gly Pro Lys Val Pro Asp Pro Glu 390 395 400 405 gac gag aag cca acg atg ggt ctg aag tgg gtc cgc ctt gtg cgc aag 1363 Asp Glu Lys Pro Thr Met Gly Leu Lys Trp Val Arg Leu Val Arg Lys 410 415 420 atg ccg gtg gct tac ctg ctg gtt ggc gtc gtt ttg ctt ggt gca atc 1411 Met Pro Val Ala Tyr Leu Leu Val Gly Val Val Leu Leu Gly Ala Ile 425 430 435 gca att cct gcg acc aat atg cgc ctg gcc atg ccg act gat ggc acc 1459 Ala Ile Pro Ala Thr Asn Met Arg Leu Ala Met Pro Thr Asp Gly Thr 440 445 450 tcc acg ctg ggc acc gcg ccg cgc acg gcg tat gac atg acg gca gat 1507 Ser Thr Leu Gly Thr Ala Pro Arg Thr Ala Tyr Asp Met Thr Ala Asp 455 460 465 gcg ttc ggc ccg ggc cgc aac gcg ccc atg att gcg ctt atc gac gca 1555 Ala Phe Gly Pro Gly Arg Asn Ala Pro Met Ile Ala Leu Ile Asp Ala 470 475 480 485 acc gac gtc cct gag gaa gaa cgc cca ttg gtg ttt gga cag gcg gtg 1603 Thr Asp Val Pro Glu Glu Glu Arg Pro Leu Val Phe Gly Gln Ala Val 490 495 500 gag caa ttc ttg aac act gat ggt gtg aag aat gct cag atc act cag 1651 Glu Gln Phe Leu Asn Thr Asp Gly Val Lys Asn Ala Gln Ile Thr Gln 505 510 515 acc acg gag aat ttc gat acc gcg cag atc ctg att acc cca gaa ttt 1699 Thr Thr Glu Asn Phe Asp Thr Ala Gln Ile Leu Ile Thr Pro Glu Phe 520 525 530 gat gcg atc gat gag cgc acc tct gag act ctc gca act ctt cgt gca 1747 Asp Ala Ile Asp Glu Arg Thr Ser Glu Thr Leu Ala Thr Leu Arg Ala 535 540 545 gat gct gag acc ttc gct gat gac acc ggc gcg acg tat ggc att act 1795 Asp Ala Glu Thr Phe Ala Asp Asp Thr Gly Ala Thr Tyr Gly Ile Thr 550 555 560 565 ggc gtc acc cca att tac gat gac atc tct gct cgc ctc ggc gac gtc 1843 Gly Val Thr Pro Ile Tyr Asp Asp Ile Ser Ala Arg Leu Gly Asp Val 570 575 580 ctg gtt cct tac gtt ctg atc gtt ttg gtt cta gcg ttc ctc gtg ctg 1891 Leu Val Pro Tyr Val Leu Ile Val Leu Val Leu Ala Phe Leu Val Leu 585 590 595 ttg ctc gtg ttc cgg tcc att tgg gtc cca ttg atc gcg gct ctg ggc 1939 Leu Leu Val Phe Arg Ser Ile Trp Val Pro Leu Ile Ala Ala Leu Gly 600 605 610 ttt ggc ttg tca gtt ctg gct acc ttt ggt gct acc gtg gcg atc ttc 1987 Phe Gly Leu Ser Val Leu Ala Thr Phe Gly Ala Thr Val Ala Ile Phe 615 620 625 caa gaa ggt gct ttc ggc atc atc gac gat cct cag cca ctg ctg tcc 2035 Gln Glu Gly Ala Phe Gly Ile Ile Asp Asp Pro Gln Pro Leu Leu Ser 630 635 640 645 ttc ttg ccg atc atg ctc atc ggc ctg gta ttt ggt ctg gcc atg gat 2083 Phe Leu Pro Ile Met Leu Ile Gly Leu Val Phe Gly Leu Ala Met Asp 650 655 660 tac cag atc ttc ctc gtt act cgt atg cgt gag ggc ttc acc aag ggc 2131 Tyr Gln Ile Phe Leu Val Thr Arg Met Arg Glu Gly Phe Thr Lys Gly 665 670 675 aag act gcg ggc aac gca acg tcg aat ggt ttc aag cac ggt gcc cgc 2179 Lys Thr Ala Gly Asn Ala Thr Ser Asn Gly Phe Lys His Gly Ala Arg 680 685 690 gtg gtc act gct gcg gcg ctg atc atg gtg tct gtg ttc gcg gca ttc 2227 Val Val Thr Ala Ala Ala Leu Ile Met Val Ser Val Phe Ala Ala Phe 695 700 705 ata gcg cag gac atg gcg ttt att aag acc atg ggc ttt gct ctg gcc 2275 Ile Ala Gln Asp Met Ala Phe Ile Lys Thr Met Gly Phe Ala Leu Ala 710 715 720 725 gtt gct gtg ttc ttc gat gcc ttc gtt gtt cgc atg atg att atc cct 2323 Val Ala Val Phe Phe Asp Ala Phe Val Val Arg Met Met Ile Ile Pro 730 735 740 gca aca atg ttc ctg ctt gat gac aag gct tgg tgg cta cct aag tgg 2371 Ala Thr Met Phe Leu Leu Asp Asp Lys Ala Trp Trp Leu Pro Lys Trp 745 750 755 ttg gat aag att ctt ccc aac gtt gat gtt gaa ggt gag ggt ctt agt 2419 Leu Asp Lys Ile Leu Pro Asn Val Asp Val Glu Gly Glu Gly Leu Ser 760 765 770 gaa cta cat gag gct cgc acc gag gaa ctg aag gaa aat gta ggt gtc 2467 Glu Leu His Glu Ala Arg Thr Glu Glu Leu Lys Glu Asn Val Gly Val 775 780 785 ggg gct tagagaaaca aaaaaggctg ctacgcggac 2503 Gly Ala 790 <210> 176 <211> 791 <212> PRT <213> Corynebacterium glutamicum <400> 176 Val Ala Lys Phe Leu Tyr Lys Leu Gly Ser Thr Ala Tyr Gln Lys Lys 1 5 10 15 Trp Pro Phe Leu Ala Val Trp Leu Val Ile Leu Ile Gly Ile Thr Thr 20 25 30 Leu Ala Gly Leu Tyr Ala Lys Pro Thr Ser Ser Ser Phe Ser Ile Pro 35 40 45 Gly Leu Asp Ser Val Thr Thr Met Glu Lys Met Gln Glu Arg Phe Pro 50 55 60 Gly Ser Asp Asp Ala Thr Ser Ala Pro Thr Gly Ser Val Val Ile Gln 65 70 75 80 Ala Pro Glu Gly Lys Thr Leu Thr Asp Pro Glu Val Gly Ala Glu Val 85 90 95 Asn Gln Met Leu Asp Glu Val Arg Ala Thr Gly Val Leu Lys Asp Ala 100 105 110 Asp Ser Val Val Asp Pro Val Leu Ala Ala Gln Gly Val Ala Ala Gln 115 120 125 Met Thr Pro Ala Leu Glu Ala Gln Gly Val Pro Ala Glu Lys Ile Ala 130 135 140 Ala Asp Ile Glu Ser Ile Ser Pro Leu Ser Ala Asp Glu Thr Thr Gly 145 150 155 160 Ile Ile Ser Met Thr Phe Asp Ala Asp Ser Ala Met Asp Ile Ser Ala 165 170 175 Glu Asp Arg Glu Lys Val Thr Asn Ile Leu Asp Glu Tyr Asp Asp Gly 180 185 190 Asp Leu Thr Val Val Tyr Asn Gly Asn Val Phe Gly Ala Ala Ala Thr 195 200 205 Ser Leu Asp Met Thr Ser Glu Leu Ile Gly Leu Leu Val Ala Ala Val 210 215 220 Val Leu Ile Val Thr Phe Gly Ser Phe Ile Ala Ala Gly Met Pro Leu 225 230 235 240 Ile Ser Ala Ile Ile Gly Val Gly Ile Gly Ile Met Gly Ile Gln Leu 245 250 255 Ala Thr Ala Phe Thr Asp Ser Val Asn Asp Met Thr Pro Thr Leu Ala 260 265 270 Ser Met Ile Gly Leu Ala Val Gly Ile Asp Tyr Ala Leu Phe Ile Val 275 280 285 Ser Arg Phe Arg Asn Glu Leu Ile Ser Gln Thr Gly Ala Asn Asp Leu 290 295 300 Glu Pro Lys Glu Leu Ala Glu Arg Leu Arg Thr Met Pro Leu Ala Ala 305 310 315 320 Arg Ala His Ala Met Gly Met Ala Val Gly Thr Ala Gly Ser Ala Val 325 330 335 Val Phe Ala Gly Thr Thr Val Leu Ile Ala Leu Val Ala Leu Ser Ile 340 345 350 Ile Asn Ile Pro Phe Leu Thr Val Met Ala Ile Ala Ala Ala Ile Thr 355 360 365 Val Ala Ile Ala Val Leu Val Ala Leu Ser Phe Leu Pro Ala Leu Leu 370 375 380 Gly Leu Leu Gly Thr Arg Ile Phe Ala Ala Arg Val Pro Gly Pro Lys 385 390 395 400 Val Pro Asp Pro Glu Asp Glu Lys Pro Thr Met Gly Leu Lys Trp Val 405 410 415 Arg Leu Val Arg Lys Met Pro Val Ala Tyr Leu Leu Val Gly Val Val 420 425 430 Leu Leu Gly Ala Ile Ala Ile Pro Ala Thr Asn Met Arg Leu Ala Met 435 440 445 Pro Thr Asp Gly Thr Ser Thr Leu Gly Thr Ala Pro Arg Thr Ala Tyr 450 455 460 Asp Met Thr Ala Asp Ala Phe Gly Pro Gly Arg Asn Ala Pro Met Ile 465 470 475 480 Ala Leu Ile Asp Ala Thr Asp Val Pro Glu Glu Glu Arg Pro Leu Val 485 490 495 Phe Gly Gln Ala Val Glu Gln Phe Leu Asn Thr Asp Gly Val Lys Asn 500 505 510 Ala Gln Ile Thr Gln Thr Thr Glu Asn Phe Asp Thr Ala Gln Ile Leu 515 520 525 Ile Thr Pro Glu Phe Asp Ala Ile Asp Glu Arg Thr Ser Glu Thr Leu 530 535 540 Ala Thr Leu Arg Ala Asp Ala Glu Thr Phe Ala Asp Asp Thr Gly Ala 545 550 555 560 Thr Tyr Gly Ile Thr Gly Val Thr Pro Ile Tyr Asp Asp Ile Ser Ala 565 570 575 Arg Leu Gly Asp Val Leu Val Pro Tyr Val Leu Ile Val Leu Val Leu 580 585 590 Ala Phe Leu Val Leu Leu Leu Val Phe Arg Ser Ile Trp Val Pro Leu 595 600 605 Ile Ala Ala Leu Gly Phe Gly Leu Ser Val Leu Ala Thr Phe Gly Ala 610 615 620 Thr Val Ala Ile Phe Gln Glu Gly Ala Phe Gly Ile Ile Asp Asp Pro 625 630 635 640 Gln Pro Leu Leu Ser Phe Leu Pro Ile Met Leu Ile Gly Leu Val Phe 645 650 655 Gly Leu Ala Met Asp Tyr Gln Ile Phe Leu Val Thr Arg Met Arg Glu 660 665 670 Gly Phe Thr Lys Gly Lys Thr Ala Gly Asn Ala Thr Ser Asn Gly Phe 675 680 685 Lys His Gly Ala Arg Val Val Thr Ala Ala Ala Leu Ile Met Val Ser 690 695 700 Val Phe Ala Ala Phe Ile Ala Gln Asp Met Ala Phe Ile Lys Thr Met 705 710 715 720 Gly Phe Ala Leu Ala Val Ala Val Phe Phe Asp Ala Phe Val Val Arg 725 730 735 Met Met Ile Ile Pro Ala Thr Met Phe Leu Leu Asp Asp Lys Ala Trp 740 745 750 Trp Leu Pro Lys Trp Leu Asp Lys Ile Leu Pro Asn Val Asp Val Glu 755 760 765 Gly Glu Gly Leu Ser Glu Leu His Glu Ala Arg Thr Glu Glu Leu Lys 770 775 780 Glu Asn Val Gly Val Gly Ala 785 790 <210> 177 <211> 1360 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1330) <223> RXA03299 <400> 177 catgctcagc agcagcatga attagaagca gaaaatgaac ggcttaaaaa agaagttgat 60 gcgctcgctg cagagcttag tgctgcgttg atgggcgagg gtg gtg gtg atc atg 115 Val Val Val Ile Met 1 5 act aag gcc gtg aca cca att gtg gtg acc gat ggt gtt cgt ttt gat 163 Thr Lys Ala Val Thr Pro Ile Val Val Thr Asp Gly Val Arg Phe Asp 10 15 20 gag gtg gat ctt gtc gct ggt aat gca cgg cta cac agt gtg ctg tca 211 Glu Val Asp Leu Val Ala Gly Asn Ala Arg Leu His Ser Val Leu Ser 25 30 35 cag ctg tgg gac aag ctg tct tta ggc tca gat aag tta agg aat ctg 259 Gln Leu Trp Asp Lys Leu Ser Leu Gly Ser Asp Lys Leu Arg Asn Leu 40 45 50 ctt ctt ggt gat agc aca cat ccg gct tat ggg cgc tca tgg gtg acc 307 Leu Leu Gly Asp Ser Thr His Pro Ala Tyr Gly Arg Ser Trp Val Thr 55 60 65 tta act gag agc att aac aag ggt gtt gct gcc ggt acg gtg aca aga 355 Leu Thr Glu Ser Ile Asn Lys Gly Val Ala Ala Gly Thr Val Thr Arg 70 75 80 85 gcg cag gag cag ctt ttt cag cag atg ctg gga ttg cgc gat att tac 403 Ala Gln Glu Gln Leu Phe Gln Gln Met Leu Gly Leu Arg Asp Ile Tyr 90 95 100 cag ggt gtc act gat gct cag aca tgg ttg ggg cag tca gca gtg tca 451 Gln Gly Val Thr Asp Ala Gln Thr Trp Leu Gly Gln Ser Ala Val Ser 105 110 115 ggt gga gag agg gtg caa tca gag ata aag gtt gtg aca gag gta gca 499 Gly Gly Glu Arg Val Gln Ser Glu Ile Lys Val Val Thr Glu Val Ala 120 125 130 cag gcg cct gtg ttg cat gag gcg gtt gca gaa tct gca gag gtg acc 547 Gln Ala Pro Val Leu His Glu Ala Val Ala Glu Ser Ala Glu Val Thr 135 140 145 cag ggg gcg cca gct gtt gaa gta gtt gcg gat cta gac gcc gcg aaa 595 Gln Gly Ala Pro Ala Val Glu Val Val Ala Asp Leu Asp Ala Ala Lys 150 155 160 165 gag cac caa cta gca cag gag ccc aag cga tct ggc aaa aaa tct gtg 643 Glu His Gln Leu Ala Gln Glu Pro Lys Arg Ser Gly Lys Lys Ser Val 170 175 180 aaa cag gca ccg cga cga caa cgt agc gct cgc aca acc acc gat gca 691 Lys Gln Ala Pro Arg Arg Gln Arg Ser Ala Arg Thr Thr Thr Asp Ala 185 190 195 gca gcg tgt aca ccg cgt gca ggt gtg gtg gcc ttt aag tca agc att 739 Ala Ala Cys Thr Pro Arg Ala Gly Val Val Ala Phe Lys Ser Ser Ile 200 205 210 acg ttg cgt gat ggc gat ggt gtg gat cta gag gat gaa ctg cgt act 787 Thr Leu Arg Asp Gly Asp Gly Val Asp Leu Glu Asp Glu Leu Arg Thr 215 220 225 gtg cac agg acg agt gcc agg ctg acc gat cta ctg cag gat cat gtg 835 Val His Arg Thr Ser Ala Arg Leu Thr Asp Leu Leu Gln Asp His Val 230 235 240 245 cac aag aag ctt gca cag cag ggt gtg acg ttt cga ggc cct att cct 883 His Lys Lys Leu Ala Gln Gln Gly Val Thr Phe Arg Gly Pro Ile Pro 250 255 260 ttc ggg atc ttg gtg aac ctc ggg att gtg tca ctg ctg gcg aat cac 931 Phe Gly Ile Leu Val Asn Leu Gly Ile Val Ser Leu Leu Ala Asn His 265 270 275 gaa gat gtc caa gga tta gtg tct tta agt gac gat gac cag ctt gtg 979 Glu Asp Val Gln Gly Leu Val Ser Leu Ser Asp Asp Asp Gln Leu Val 280 285 290 ctc gac att ctc aat gaa cac cga tct gta ggt tgg cag gaa agt gtc 1027 Leu Asp Ile Leu Asn Glu His Arg Ser Val Gly Trp Gln Glu Ser Val 295 300 305 aat gac gcg ctt gat gaa cag gcg cag cag atg gcg cag atc aac aag 1075 Asn Asp Ala Leu Asp Glu Gln Ala Gln Gln Met Ala Gln Ile Asn Lys 310 315 320 325 aca ctg ggc ttt ttg cac aag cgc agc gta caa aac gaa cgc gac aat 1123 Thr Leu Gly Phe Leu His Lys Arg Ser Val Gln Asn Glu Arg Asp Asn 330 335 340 ttc ttt ttt gag cat ttg ctc agt gcg ttt ttc gca gaa cgc ctc atg 1171 Phe Phe Phe Glu His Leu Leu Ser Ala Phe Phe Ala Glu Arg Leu Met 345 350 355 atc ggt gat att gcg act ggt tca gca gta gaa gac att gat cta cac 1219 Ile Gly Asp Ile Ala Thr Gly Ser Ala Val Glu Asp Ile Asp Leu His 360 365 370 agt gaa aag cat gag aaa gtg ctt gct gta ttg aaa aag tca tcg gag 1267 Ser Glu Lys His Glu Lys Val Leu Ala Val Leu Lys Lys Ser Ser Glu 375 380 385 cat gag tgg cag cgg ggg aaa gac gta gcc ggg aga cag ttc cat gcg 1315 His Glu Trp Gln Arg Gly Lys Asp Val Ala Gly Arg Gln Phe His Ala 390 395 400 405 gtg cga aat gat gac tgaaggcttt cgacttaata ctgatgcaga 1360 Val Arg Asn Asp Asp 410 <210> 178 <211> 410 <212> PRT <213> Corynebacterium glutamicum <400> 178 Val Val Val Ile Met Thr Lys Ala Val Thr Pro Ile Val Val Thr Asp 1 5 10 15 Gly Val Arg Phe Asp Glu Val Asp Leu Val Ala Gly Asn Ala Arg Leu 20 25 30 His Ser Val Leu Ser Gln Leu Trp Asp Lys Leu Ser Leu Gly Ser Asp 35 40 45 Lys Leu Arg Asn Leu Leu Leu Gly Asp Ser Thr His Pro Ala Tyr Gly 50 55 60 Arg Ser Trp Val Thr Leu Thr Glu Ser Ile Asn Lys Gly Val Ala Ala 65 70 75 80 Gly Thr Val Thr Arg Ala Gln Glu Gln Leu Phe Gln Gln Met Leu Gly 85 90 95 Leu Arg Asp Ile Tyr Gln Gly Val Thr Asp Ala Gln Thr Trp Leu Gly 100 105 110 Gln Ser Ala Val Ser Gly Gly Glu Arg Val Gln Ser Glu Ile Lys Val 115 120 125 Val Thr Glu Val Ala Gln Ala Pro Val Leu His Glu Ala Val Ala Glu 130 135 140 Ser Ala Glu Val Thr Gln Gly Ala Pro Ala Val Glu Val Val Ala Asp 145 150 155 160 Leu Asp Ala Ala Lys Glu His Gln Leu Ala Gln Glu Pro Lys Arg Ser 165 170 175 Gly Lys Lys Ser Val Lys Gln Ala Pro Arg Arg Gln Arg Ser Ala Arg 180 185 190 Thr Thr Thr Asp Ala Ala Ala Cys Thr Pro Arg Ala Gly Val Val Ala 195 200 205 Phe Lys Ser Ser Ile Thr Leu Arg Asp Gly Asp Gly Val Asp Leu Glu 210 215 220 Asp Glu Leu Arg Thr Val His Arg Thr Ser Ala Arg Leu Thr Asp Leu 225 230 235 240 Leu Gln Asp His Val His Lys Lys Leu Ala Gln Gln Gly Val Thr Phe 245 250 255 Arg Gly Pro Ile Pro Phe Gly Ile Leu Val Asn Leu Gly Ile Val Ser 260 265 270 Leu Leu Ala Asn His Glu Asp Val Gln Gly Leu Val Ser Leu Ser Asp 275 280 285 Asp Asp Gln Leu Val Leu Asp Ile Leu Asn Glu His Arg Ser Val Gly 290 295 300 Trp Gln Glu Ser Val Asn Asp Ala Leu Asp Glu Gln Ala Gln Gln Met 305 310 315 320 Ala Gln Ile Asn Lys Thr Leu Gly Phe Leu His Lys Arg Ser Val Gln 325 330 335 Asn Glu Arg Asp Asn Phe Phe Phe Glu His Leu Leu Ser Ala Phe Phe 340 345 350 Ala Glu Arg Leu Met Ile Gly Asp Ile Ala Thr Gly Ser Ala Val Glu 355 360 365 Asp Ile Asp Leu His Ser Glu Lys His Glu Lys Val Leu Ala Val Leu 370 375 380 Lys Lys Ser Ser Glu His Glu Trp Gln Arg Gly Lys Asp Val Ala Gly 385 390 395 400 Arg Gln Phe His Ala Val Arg Asn Asp Asp 405 410 <210> 179 <211> 9037 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(9007) <223> RXA03376 <400> 179 agggtttagt catctatttc ggctacgctc acgtaaccta cgcattcgta agtggtcatg 60 ggtccaagaa gcccattcca agacttagga gctttatttc gtg agt att tct tca 115 Val Ser Ile Ser Ser 1 5 ctg aca ccg ctg cac tct ttc aaa gag cca gca att ctg tac gcc ggt 163 Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala Ile Leu Tyr Ala Gly 10 15 20 cag gct tct gcc tgg cag cag gtg atc gct gat tcc agc gaa gac cac 211 Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp Ser Ser Glu Asp His 25 30 35 atc acc gca acg cac ctg cgc gag ctc ctg tct cgc tcc cgt gca aag 259 Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser Arg Ser Arg Ala Lys 40 45 50 act gca cct ttc gct cgc caa atc acc gcc atc gtg cct ggc tca ctt 307 Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile Val Pro Gly Ser Leu 55 60 65 gct cgt ctt gag gaa ctg acc cgc gaa gac gca caa atc ggt gca gac 355 Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala Gln Ile Gly Ala Asp 70 75 80 85 atc gac gca cag cct gcc gtt tcc att cca ggc att ctg ctg gga cag 403 Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly Ile Leu Leu Gly Gln 90 95 100 atc gct gca acc cgt cag ctg cgt gac ctc gga ctc gat gtc gca gca 451 Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly Leu Asp Val Ala Ala 105 110 115 gct tcc cgc ctt gga cac tcc cag ggc att ttg ggc gtt gaa gca gta 499 Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu Gly Val Glu Ala Val 120 125 130 gac aat gaa gaa gac gtt tta gct ttc gcc atc ctg ctg ggc gca gca 547 Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile Leu Leu Gly Ala Ala 135 140 145 gct tcc cag ttc gct ggc aag ggc gca cat atg ctc tct gtt cgc ggc 595 Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met Leu Ser Val Arg Gly 150 155 160 165 ctg tcc cgt gag atc atc cag gac acc atc gct ggt gtc gat ggg gta 643 Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala Gly Val Asp Gly Val 170 175 180 gag gtc tcc ctg cgc aac gct cgt gca cac ttt gtt gtc tct ggt aag 691 Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Gly Lys 185 190 195 cca gag gca ctg aag aag gct gct gct gct cta cag cgc gca gct gat 739 Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu Gln Arg Ala Ala Asp 200 205 210 gtt tac aac gaa gac atc aac gaa aag cgc aag ggt gga tcc ctg gca 787 Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys Gly Gly Ser Leu Ala 215 220 225 gag cct aag ttt gac tac ttg gat gtg gcc att cct ttc cac cac tcc 835 Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile Pro Phe His His Ser 230 235 240 245 tcc atg cag gac gca gcc gac ttg gct gtc gag tgg gca acc acc tgt 883 Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu Trp Ala Thr Thr Cys 250 255 260 ggc cta aac gtc aac gcg cgc gcg ttg gca gaa gca att cta gtt aac 931 Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu Ala Ile Leu Val Asn 265 270 275 cca gct gac tgg gtt gag cag atc gca aac ctc aag gct gat tac gtt 979 Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu Lys Ala Asp Tyr Val 280 285 290 ctt tcc ctc gat gca ggc gtc agc cgt ttc acc gct cca ttg cta gac 1027 Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr Ala Pro Leu Leu Asp 295 300 305 ggt cgc gga atc tct ttg gtt cct gcg ttc tcc gct gca gag cgc gac 1075 Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser Ala Ala Glu Arg Asp 310 315 320 325 aac ttg gct cgc cct ggc ttc cac gtt cct acc gct gag gat tgg tcc 1123 Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr Ala Glu Asp Trp Ser 330 335 340 gag ttc gct cca aag ctg gtt aag ctt cca aac ggt gag cac aag gtt 1171 Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn Gly Glu His Lys Val 345 350 355 ctc acc ggg ttc tcc cgc ctg act ggt tat tcc cca atc gtc ctg gct 1219 Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser Pro Ile Val Leu Ala 360 365 370 ggc atg acc cca acc acc gtt gat cct gag atc gtt gca gct gca gcg 1267 Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile Val Ala Ala Ala Ala 375 380 385 aac gct gga cac tgg gcc gaa atg gcc ggt ggc gga cag tac tct gaa 1315 Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly Gly Gln Tyr Ser Glu 390 395 400 405 gaa gtc ttc acc aag aac aag gaa aag ctc gtt tcc ctg ctc aag gtt 1363 Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val Ser Leu Leu Lys Val 410 415 420 gga cgc tcc gca cag ttc aac tcc atg ttc ttc gac cgc tac atg tgg 1411 Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe Asp Arg Tyr Met Trp 425 430 435 aac ctg cag ttc ggt gca cag cgc atc gtt tcc aag gca cgt gca acc 1459 Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser Lys Ala Arg Ala Thr 440 445 450 ggt acc tcc atc aac ggt gtt gtt gtc tcc gct ggt atc cca gag gtt 1507 Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala Gly Ile Pro Glu Val 455 460 465 gag gaa gca act gag ctg atc aac gat ctg aac gct gat ggc ttc cca 1555 Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn Ala Asp Gly Phe Pro 470 475 480 485 tac gtt gca ttc aag cca ggc acc gtg gat cag atc cgc gca acc ctg 1603 Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln Ile Arg Ala Thr Leu 490 495 500 aag att gct gat gca aac cca gag acc aag atc atc atc cag atc gag 1651 Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile Ile Ile Gln Ile Glu 505 510 515 gac gga cac gct ggt ggc cac cac tcc tgg gtc aac ttg gac gat ctg 1699 Asp Gly His Ala Gly Gly His His Ser Trp Val Asn Leu Asp Asp Leu 520 525 530 ctc ctg acc acc tac gca gag ctg cgt tcc cgc aag aac gtt gtc gtc 1747 Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg Lys Asn Val Val Val 535 540 545 atg atc ggt ggc ggc atc gga acc cct gca aag gct gct tac tac ctg 1795 Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys Ala Ala Tyr Tyr Leu 550 555 560 565 acc ggt gaa tgg tcc acc gat ttg ggc ttc cca gca atg cca gtg gac 1843 Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro Ala Met Pro Val Asp 570 575 580 ggc atc ctc gtg ggt acc gct gcc atg gca acc aag gaa gca acc act 1891 Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr 585 590 595 tct cct cag gtc aag cag gca ctg gtc gac acc cca ggt gtt gat cca 1939 Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr Pro Gly Val Asp Pro 600 605 610 cac gac gct ggc ggc tgg gtt ggc cgt ggc gat gct cgt ggt ggc gtg 1987 His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp Ala Arg Gly Gly Val 615 620 625 acc tct ggt ctg tca cac ctg cac gct gac atg tac gag ctg gac aac 2035 Thr Ser Gly Leu Ser His Leu His Ala Asp Met Tyr Glu Leu Asp Asn 630 635 640 645 gat tct gct gca gct tcc cgc ctg atc tct tcc atc gat tct gat gat 2083 Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser Ile Asp Ser Asp Asp 650 655 660 tac gca gat cac cgc gaa gag ctc atc gag gct atc aac aag acc gct 2131 Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala Ile Asn Lys Thr Ala 665 670 675 aag cct ttc ttc ggc gag gtc gaa gag atg act tac gca gag tgg atc 2179 Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr Tyr Ala Glu Trp Ile 680 685 690 cag cgt tgg gtt gag ctt gct tac cca act cag gac cca acc tgg gat 2227 Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln Asp Pro Thr Trp Asp 695 700 705 gat cgt ttc ctc gat ttg gtt cac cgc att gaa gct cgt ctc aac gag 2275 Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu Ala Arg Leu Asn Glu 710 715 720 725 gca gag cac ggc gcc atc acc aca ctg ttc cca gac cat gcg tct gtg 2323 Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro Asp His Ala Ser Val 730 735 740 gaa aat gag gaa gag gcc gtc gaa aag ctt ctt gct gct tac ccg cag 2371 Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu Ala Ala Tyr Pro Gln 745 750 755 gcc cgc gag atc cag gtc tct gcg cgc gac gcc gcg tgg ttt att ggt 2419 Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala Ala Trp Phe Ile Gly 760 765 770 ctg tgc cgc aag cac cac aag cct atg cct tgg gtt cca gca atc gat 2467 Leu Cys Arg Lys His His Lys Pro Met Pro Trp Val Pro Ala Ile Asp 775 780 785 gct gac cta gca cgc tgg tgg ggc ctt gac acc ctg tgg cag tcc cag 2515 Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr Leu Trp Gln Ser Gln 790 795 800 805 aac gag cgc tac ggc gcg aac tca gtc cgc gtt atc cca gga cca gtc 2563 Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val Ile Pro Gly Pro Val 810 815 820 tcc gtc gcc ggc atc gac cgt gtt gac gag cca gtt gca gag ctg ctc 2611 Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro Val Ala Glu Leu Leu 825 830 835 ggc cgc ttc gaa gct gcc tgc gtt gac gct ctc gac ggc gag cca gaa 2659 Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu Asp Gly Glu Pro Glu 840 845 850 gag atc ttc gct cgc ctc aat gag tcc aag aac gag cgc gaa ttc ctg 2707 Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn Glu Arg Glu Phe Leu 855 860 865 ctg gct acc cca cac atc gtg tgg cac ggc aac ctg atc gac aac cca 2755 Leu Ala Thr Pro His Ile Val Trp His Gly Asn Leu Ile Asp Asn Pro 870 875 880 885 gct cac gtc ctc aac gag ggt gct ttc gag ctc atc gag gag gat ggc 2803 Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu Ile Glu Glu Asp Gly 890 895 900 tac tgg gtc atc cgt atc ctg gct gat tcc tac ttc gac gat ctg cca 2851 Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr Phe Asp Asp Leu Pro 905 910 915 gtt gag cag cgc cca tac ctg gtt cag cat gtt gac atc cca gtt gag 2899 Val Glu Gln Arg Pro Tyr Leu Val Gln His Val Asp Ile Pro Val Glu 920 925 930 ctg ggt gac gct gtt gca acc ggt ggc tcc cca gtt gtt tcc cgt gag 2947 Leu Gly Asp Ala Val Ala Thr Gly Gly Ser Pro Val Val Ser Arg Glu 935 940 945 aag ctg cct gag tct gtc ttc gca ctt ctt gct ggc gtt gct ggt gtt 2995 Lys Leu Pro Glu Ser Val Phe Ala Leu Leu Ala Gly Val Ala Gly Val 950 955 960 965 gga tct gtt tcc gct gct ggc gat gag atc aag gca ctt cca gag gca 3043 Gly Ser Val Ser Ala Ala Gly Asp Glu Ile Lys Ala Leu Pro Glu Ala 970 975 980 gtt cag gac ggc acc cca ttc ggc acc gtc cgc gat tct ttc acc ctg 3091 Val Gln Asp Gly Thr Pro Phe Gly Thr Val Arg Asp Ser Phe Thr Leu 985 990 995 cct gca tcc ctg ctg acc gca cac acc gca gtc acc ggc gca gcg ctg 3139 Pro Ala Ser Leu Leu Thr Ala His Thr Ala Val Thr Gly Ala Ala Leu 1000 1005 1010 gaa gca cac aac gtt ggc acc cca gac gtc ctg atg ggc gct tgc tgg 3187 Glu Ala His Asn Val Gly Thr Pro Asp Val Leu Met Gly Ala Cys Trp 1015 1020 1025 cca gca atc tac gcg gcc cta ggc acc ggt aag ctc tcc gat ggc tat 3235 Pro Ala Ile Tyr Ala Ala Leu Gly Thr Gly Lys Leu Ser Asp Gly Tyr 1030 1035 1040 1045 cca gtc atc gaa ggc ctg ctc aac gca gtc cac ctg gat cac ctt ctt 3283 Pro Val Ile Glu Gly Leu Leu Asn Ala Val His Leu Asp His Leu Leu 1050 1055 1060 gat ctg cgc atc cca ctc gag gag ctg gca aac ggc cgc acc atc gat 3331 Asp Leu Arg Ile Pro Leu Glu Glu Leu Ala Asn Gly Arg Thr Ile Asp 1065 1070 1075 gtt gag gca cgc acc gac tcc atc gaa gag tcc gca tcc ggc cgt atc 3379 Val Glu Ala Arg Thr Asp Ser Ile Glu Glu Ser Ala Ser Gly Arg Ile 1080 1085 1090 gtt acc gtg cgc atc gtg ctc acc acc gaa ggc gaa gta gca gcc aag 3427 Val Thr Val Arg Ile Val Leu Thr Thr Glu Gly Glu Val Ala Ala Lys 1095 1100 1105 ctg gtt acc cgc ttc gca att cgt gga cgc atc acc acc aac gaa atg 3475 Leu Val Thr Arg Phe Ala Ile Arg Gly Arg Ile Thr Thr Asn Glu Met 1110 1115 1120 1125 gct gca cca gca gat tcc tac ggc gca cgc gac gaa gtt gtc gag gca 3523 Ala Ala Pro Ala Asp Ser Tyr Gly Ala Arg Asp Glu Val Val Glu Ala 1130 1135 1140 acc cct cgt tcc ttc atc cgc cag gca act gtt tct gca cct gca gac 3571 Thr Pro Arg Ser Phe Ile Arg Gln Ala Thr Val Ser Ala Pro Ala Asp 1145 1150 1155 atg acc cca ttc gcc atg gtt tct ggt gac tac aac cca att cac acc 3619 Met Thr Pro Phe Ala Met Val Ser Gly Asp Tyr Asn Pro Ile His Thr 1160 1165 1170 tct gac aac gct gca aag ctt gtt ggc ctg gac gca gct ctt gtc cac 3667 Ser Asp Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His 1175 1180 1185 ggc atg tgg ctg tcc gct acc gca cag cac ctc gct ggt ctt ggc tct 3715 Gly Met Trp Leu Ser Ala Thr Ala Gln His Leu Ala Gly Leu Gly Ser 1190 1195 1200 1205 gag gtc att ggt tgg acc tac tcc atg tac ggc atg gtt cag ctc aac 3763 Glu Val Ile Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gln Leu Asn 1210 1215 1220 gac gtt gtt gac atc acc gtc gag cgt gtt ggc cgc gca ggt ctg aag 3811 Asp Val Val Asp Ile Thr Val Glu Arg Val Gly Arg Ala Gly Leu Lys 1225 1230 1235 cct gca tac gag gtc acc tgc cgc att gat ggc aac gtt gtc tcc cgc 3859 Pro Ala Tyr Glu Val Thr Cys Arg Ile Asp Gly Asn Val Val Ser Arg 1240 1245 1250 gga cag gca ctg ctc aag gct cct tcc acc gct tat gtt tac cca agc 3907 Gly Gln Ala Leu Leu Lys Ala Pro Ser Thr Ala Tyr Val Tyr Pro Ser 1255 1260 1265 cag ggc atc cag gct aag ggc atg ggc caa ggc gat cgc acc gca agc 3955 Gln Gly Ile Gln Ala Lys Gly Met Gly Gln Gly Asp Arg Thr Ala Ser 1270 1275 1280 1285 gca gag gct cgc gct gtg tgg gag cgt gca gat gca cac acc cgc gca 4003 Ala Glu Ala Arg Ala Val Trp Glu Arg Ala Asp Ala His Thr Arg Ala 1290 1295 1300 aac ctg ggc ttc tcc atc cag cag gtc att gat gaa aac cca act gag 4051 Asn Leu Gly Phe Ser Ile Gln Gln Val Ile Asp Glu Asn Pro Thr Glu 1305 1310 1315 ctg aag gtc ggg gac acc acc ttc gtg cac cca gct ggg gtt ttg aac 4099 Leu Lys Val Gly Asp Thr Thr Phe Val His Pro Ala Gly Val Leu Asn 1320 1325 1330 ctc acc cag ttc acg cag gtc gcg ctc gcc gtg gtt gcc tac gct cag 4147 Leu Thr Gln Phe Thr Gln Val Ala Leu Ala Val Val Ala Tyr Ala Gln 1335 1340 1345 acc gag cgc ctc aag gct gca aac gca att gtc gac ggc tcc ctc tac 4195 Thr Glu Arg Leu Lys Ala Ala Asn Ala Ile Val Asp Gly Ser Leu Tyr 1350 1355 1360 1365 gca ggc cac tcc ctc ggc gag tac acc gca ctg gca tcc ttg ggc aac 4243 Ala Gly His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn 1370 1375 1380 atc ttc gaa ctc gaa ggc gtc atc gac gtt gtg ttc tcc cgc ggt tcc 4291 Ile Phe Glu Leu Glu Gly Val Ile Asp Val Val Phe Ser Arg Gly Ser 1385 1390 1395 gca atg cac tcc ctg gtt cca cgt gat gag aag ggc cgt tcc aac tac 4339 Ala Met His Ser Leu Val Pro Arg Asp Glu Lys Gly Arg Ser Asn Tyr 1400 1405 1410 ggt ctt gcc gca ttc cgt ccg aac atg atc aac gtt gca gcc acc gag 4387 Gly Leu Ala Ala Phe Arg Pro Asn Met Ile Asn Val Ala Ala Thr Glu 1415 1420 1425 gtg gag aac tgg gtt gac cgt gtc gct gaa gaa tcc ggc gaa ttc ctg 4435 Val Glu Asn Trp Val Asp Arg Val Ala Glu Glu Ser Gly Glu Phe Leu 1430 1435 1440 1445 cag atc gtt aac tac aac gtt gat ggc cag cag tac gca gtc gca ggt 4483 Gln Ile Val Asn Tyr Asn Val Asp Gly Gln Gln Tyr Ala Val Ala Gly 1450 1455 1460 acc ttg gct ggc ctg aag gcc ctc aag gct tct gca tct gca aac cca 4531 Thr Leu Ala Gly Leu Lys Ala Leu Lys Ala Ser Ala Ser Ala Asn Pro 1465 1470 1475 cgt gct tac gtg aac att cca ggc att gac gtg cca ttc cac tcc agc 4579 Arg Ala Tyr Val Asn Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser 1480 1485 1490 gtc ctg cgc cca ggc gtt cct gct ttc gca gag aag ctg gac gag ctg 4627 Val Leu Arg Pro Gly Val Pro Ala Phe Ala Glu Lys Leu Asp Glu Leu 1495 1500 1505 ctg cca gag acc atc gac att gat gct ctt cgc ggc cgc tac atc ccg 4675 Leu Pro Glu Thr Ile Asp Ile Asp Ala Leu Arg Gly Arg Tyr Ile Pro 1510 1515 1520 1525 aac ctg gtt gct cgt cct ttc gag ctc acc cag agc ttc gtg gat gcc 4723 Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Gln Ser Phe Val Asp Ala 1530 1535 1540 atc ctt gct gtt gtt cca tcc gag cgc ctc aag ggc atc aag gtg gag 4771 Ile Leu Ala Val Val Pro Ser Glu Arg Leu Lys Gly Ile Lys Val Glu 1545 1550 1555 gac acc gac gag aac acc ctg gca cgt ctg ctc ctc atc gag ctg ctg 4819 Asp Thr Asp Glu Asn Thr Leu Ala Arg Leu Leu Leu Ile Glu Leu Leu 1560 1565 1570 tct tgg cag ttc gca tcc cct gtg cgt tgg atc gaa acc cag gct ctg 4867 Ser Trp Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Ala Leu 1575 1580 1585 atc atc gat acc gtc gat cag atc atc gag gtc ggc ttg gca gca tcg 4915 Ile Ile Asp Thr Val Asp Gln Ile Ile Glu Val Gly Leu Ala Ala Ser 1590 1595 1600 1605 cca acc ctg acc aac ctg gca ctg cgc acc atg gat gtc att ggc aag 4963 Pro Thr Leu Thr Asn Leu Ala Leu Arg Thr Met Asp Val Ile Gly Lys 1610 1615 1620 tcc cgc cca gta ttc aac gtg gag cgc gac cag gac acc gtt atg ctc 5011 Ser Arg Pro Val Phe Asn Val Glu Arg Asp Gln Asp Thr Val Met Leu 1625 1630 1635 aac gat gtt cgc cag gca cct gtt gct gag gtt gaa gaa gaa gca gtt 5059 Asn Asp Val Arg Gln Ala Pro Val Ala Glu Val Glu Glu Glu Ala Val 1640 1645 1650 gag gaa gca cct gca gca gcc gca gct cca gca gct gag gca cca gtt 5107 Glu Glu Ala Pro Ala Ala Ala Ala Ala Pro Ala Ala Glu Ala Pro Val 1655 1660 1665 gct gca gct cca gta gcc gca gcc gca cct gca cct gtt gga aac gca 5155 Ala Ala Ala Pro Val Ala Ala Ala Ala Pro Ala Pro Val Gly Asn Ala 1670 1675 1680 1685 cct gaa ctg aag ttc aac gct gcc aat gcc atc atg gtt ctc ttc gct 5203 Pro Glu Leu Lys Phe Asn Ala Ala Asn Ala Ile Met Val Leu Phe Ala 1690 1695 1700 gtc cag aac aag atc aac att gat cag atc acc gca gcg gat acc tct 5251 Val Gln Asn Lys Ile Asn Ile Asp Gln Ile Thr Ala Ala Asp Thr Ser 1705 1710 1715 gag acc ctg acc aac ggt gtg tcc tca cgc cgt aac cag atg ctc atg 5299 Glu Thr Leu Thr Asn Gly Val Ser Ser Arg Arg Asn Gln Met Leu Met 1720 1725 1730 gac atg tcc acc gag ctg tcc gtc cca acc atc gac ggc gca gct gac 5347 Asp Met Ser Thr Glu Leu Ser Val Pro Thr Ile Asp Gly Ala Ala Asp 1735 1740 1745 gct gac gta gct acc ctg cag gga cgt gtt gtc acc gca gct cct ggc 5395 Ala Asp Val Ala Thr Leu Gln Gly Arg Val Val Thr Ala Ala Pro Gly 1750 1755 1760 1765 tac aag cct ttc gga cca gtt ctt tcc gag acc gtt cgt gca cgt ctt 5443 Tyr Lys Pro Phe Gly Pro Val Leu Ser Glu Thr Val Arg Ala Arg Leu 1770 1775 1780 cgc gca ctg acc ggt gca gca ggt ctg aag acc tcc tac atc ggc gat 5491 Arg Ala Leu Thr Gly Ala Ala Gly Leu Lys Thr Ser Tyr Ile Gly Asp 1785 1790 1795 cgc gtg acc ggc acc tgg gga ctt cca gaa agc tgg acc gca cac gtt 5539 Arg Val Thr Gly Thr Trp Gly Leu Pro Glu Ser Trp Thr Ala His Val 1800 1805 1810 gag gtt gaa ttg ctg ctg ggc acc cgc gaa ggc gag tcc gtc cgc ggc 5587 Glu Val Glu Leu Leu Leu Gly Thr Arg Glu Gly Glu Ser Val Arg Gly 1815 1820 1825 ggc aac ctg ggt agc ctg cct gct aac gca tcc agc aag ggc gac gtc 5635 Gly Asn Leu Gly Ser Leu Pro Ala Asn Ala Ser Ser Lys Gly Asp Val 1830 1835 1840 1845 gat gcg ctt atc gac gca gcc gtg cag aat gtt gct gca gcc aac ggc 5683 Asp Ala Leu Ile Asp Ala Ala Val Gln Asn Val Ala Ala Ala Asn Gly 1850 1855 1860 acc agc gtc tcc atg tcc tcc ggc ggt gca gct tca ggt ggc gga gtt 5731 Thr Ser Val Ser Met Ser Ser Gly Gly Ala Ala Ser Gly Gly Gly Val 1865 1870 1875 gtt gat tcc gca gca ctt gat gcc tac gca tcc acc gtc act ggt gaa 5779 Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Glu 1880 1885 1890 gaa ggc gtc ctg gca aac gtt gct cgc ggc atc ctg tct cag ctt ggt 5827 Glu Gly Val Leu Ala Asn Val Ala Arg Gly Ile Leu Ser Gln Leu Gly 1895 1900 1905 ctc gac acc aag gac gag gtt gaa ggc gca gag atc gac acc gaa ctc 5875 Leu Asp Thr Lys Asp Glu Val Glu Gly Ala Glu Ile Asp Thr Glu Leu 1910 1915 1920 1925 tac gac gct gtc gaa gca gaa ctg ggc acc ggc tgg ctg aag ctt gtc 5923 Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr Gly Trp Leu Lys Leu Val 1930 1935 1940 acc cca gtg ttc tcc gct gat cgt gcg atc ttg ttc gac gac cgt tgg 5971 Thr Pro Val Phe Ser Ala Asp Arg Ala Ile Leu Phe Asp Asp Arg Trp 1945 1950 1955 gca tct gca cgt gaa gat ctg gca cgc ctt gcc aac ggc gag gat att 6019 Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu Ala Asn Gly Glu Asp Ile 1960 1965 1970 gcc gtc gag cgc ttt gct gga acg ggg gag acc gtc gtc aag caa gct 6067 Ala Val Glu Arg Phe Ala Gly Thr Gly Glu Thr Val Val Lys Gln Ala 1975 1980 1985 gca tgg tgg gct gag cac gtt gaa gac acc gct ctc gct gca acc ctg 6115 Ala Trp Trp Ala Glu His Val Glu Asp Thr Ala Leu Ala Ala Thr Leu 1990 1995 2000 2005 aag cag gtt tcc gag gtg gct gcg aag cca gcc aac gag cca cac atc 6163 Lys Gln Val Ser Glu Val Ala Ala Lys Pro Ala Asn Glu Pro His Ile 2010 2015 2020 gac gat gtt gcg ctg gtt acc ggt gcg gct cct gag tcg atc gcc ggt 6211 Asp Asp Val Ala Leu Val Thr Gly Ala Ala Pro Glu Ser Ile Ala Gly 2025 2030 2035 gca gtt gcg gct cgc ctg ctg tcc cag ggc gcg acc gtc att ctc acc 6259 Ala Val Ala Ala Arg Leu Leu Ser Gln Gly Ala Thr Val Ile Leu Thr 2040 2045 2050 gca tcg aac gtc tcc cag gcg cgt aag gaa tac gca cgc aag ctc tac 6307 Ala Ser Asn Val Ser Gln Ala Arg Lys Glu Tyr Ala Arg Lys Leu Tyr 2055 2060 2065 gct gcg aac gca acc cct aac gca aag ctg tgg att gtt cct gcg aac 6355 Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu Trp Ile Val Pro Ala Asn 2070 2075 2080 2085 atg tcc tcc tac cgc gat gtt gat gca gtc atc gat tgg atc ggc aac 6403 Met Ser Ser Tyr Arg Asp Val Asp Ala Val Ile Asp Trp Ile Gly Asn 2090 2095 2100 gag cag cgc gtc acc gtc ggc agc acc gtc acc gtg acc aag cca gct 6451 Glu Gln Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Ala 2105 2110 2115 ctg acc cca acc ctt gcg tac cca ttc gca gct cca tcc gta tcc ggt 6499 Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala Ala Pro Ser Val Ser Gly 2120 2125 2130 acc ttg gcg gat gca ggc cca cag gct gaa aac cag gca cgc ctg ctc 6547 Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu Asn Gln Ala Arg Leu Leu 2135 2140 2145 ctc tgg tcc gtg gag cgc acc atc gca gga ctt gca gat ctt gca tcc 6595 Leu Trp Ser Val Glu Arg Thr Ile Ala Gly Leu Ala Asp Leu Ala Ser 2150 2155 2160 2165 cgc ggt gtc gat gga cgc gtc cac gtt gta ctc cca ggt tcc ccg aac 6643 Arg Gly Val Asp Gly Arg Val His Val Val Leu Pro Gly Ser Pro Asn 2170 2175 2180 cgc gga atg ttc ggt ggc gac ggc gct tac ggc gaa gtc aag gct gct 6691 Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr Gly Glu Val Lys Ala Ala 2185 2190 2195 ttc gac gcc atc ctt gcc aag tgg ggc tcc gag acc ggc tgg cca cag 6739 Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser Glu Thr Gly Trp Pro Gln 2200 2205 2210 ttt gtc tcc ctc gca cag gca cgc atc ggc tgg gtc gca ggc acc ggc 6787 Phe Val Ser Leu Ala Gln Ala Arg Ile Gly Trp Val Ala Gly Thr Gly 2215 2220 2225 ctc atg ggt cgc aac gac gtg ctc atc cct gcc gct gaa aag ctg ggc 6835 Leu Met Gly Arg Asn Asp Val Leu Ile Pro Ala Ala Glu Lys Leu Gly 2230 2235 2240 2245 atc cac gtc tac acc cct gaa gag atc tct tcc gaa ctg ctg ggt ctt 6883 Ile His Val Tyr Thr Pro Glu Glu Ile Ser Ser Glu Leu Leu Gly Leu 2250 2255 2260 gca tcc gca gaa tcc cgc gaa aag gct ctg gaa gca ccg atc gat tac 6931 Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu Glu Ala Pro Ile Asp Tyr 2265 2270 2275 gac ctg acc ggt gga ctt tcc ggt ggc gta tcc atc gca gca ctg gca 6979 Asp Leu Thr Gly Gly Leu Ser Gly Gly Val Ser Ile Ala Ala Leu Ala 2280 2285 2290 gca tcc ctc gag tcc gac gca gta gag acc acc tct gca gca gaa gac 7027 Ala Ser Leu Glu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Glu Asp 2295 2300 2305 acc atc aag gcg ctt cca tca cct aag cac cca gag cag cca gtg ggc 7075 Thr Ile Lys Ala Leu Pro Ser Pro Lys His Pro Glu Gln Pro Val Gly 2310 2315 2320 2325 acg cca gtt gga gag gtc aag acc gat ctc gaa gac atg gtt gtc atg 7123 Thr Pro Val Gly Glu Val Lys Thr Asp Leu Glu Asp Met Val Val Met 2330 2335 2340 gtt ggc gtt ggc gaa gtc tcc tca tgg ggc tcc gga cgt acc cgc ttc 7171 Val Gly Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe 2345 2350 2355 gaa gct gag tac ggc atc cag cgc gac ggc tcc gtt gac ctc acc gca 7219 Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly Ser Val Asp Leu Thr Ala 2360 2365 2370 gca ggc gtc ctt gag ctt gca tgg atg atg ggt ctg atc tcc tgg agc 7267 Ala Gly Val Leu Glu Leu Ala Trp Met Met Gly Leu Ile Ser Trp Ser 2375 2380 2385 gaa gat cca aag cca gcc tgg tac gac gct gac ggc acc gaa gtg cct 7315 Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala Asp Gly Thr Glu Val Pro 2390 2395 2400 2405 gaa gaa gag atc tac gag cgc ttc cgc gac gaa gtc atc gca cga tgc 7363 Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp Glu Val Ile Ala Arg Cys 2410 2415 2420 ggt gtt cgt gag ctt gtc gac gac gca ttc ctc gtc gac ggc ggc tcc 7411 Gly Val Arg Glu Leu Val Asp Asp Ala Phe Leu Val Asp Gly Gly Ser 2425 2430 2435 ctc gac gca gct gaa gtc ttc ctc gac cgc gac atc tcc ttc tcc gta 7459 Leu Asp Ala Ala Glu Val Phe Leu Asp Arg Asp Ile Ser Phe Ser Val 2440 2445 2450 acc tct gct gaa gaa gca cag gcc tac gtc gat gca gat gct tcc gtg 7507 Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val Asp Ala Asp Ala Ser Val 2455 2460 2465 acc gtt gaa gaa gca gac ggc gaa tgg atc gtg acc aag aag aag ggc 7555 Thr Val Glu Glu Ala Asp Gly Glu Trp Ile Val Thr Lys Lys Lys Gly 2470 2475 2480 2485 tcc acc tcc ttc gtg cca cgc aag gca acc ctg acc cgc tcc gta gca 7603 Ser Thr Ser Phe Val Pro Arg Lys Ala Thr Leu Thr Arg Ser Val Ala 2490 2495 2500 ggc cag ctg cca acc gac ttc gac cct gcc aag tgg ggt atc cca gcc 7651 Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala Lys Trp Gly Ile Pro Ala 2505 2510 2515 tcc atg atc gat gca ctc gac aac atc gca gcg tgg aac ctg gtc act 7699 Ser Met Ile Asp Ala Leu Asp Asn Ile Ala Ala Trp Asn Leu Val Thr 2520 2525 2530 gca gtc gac gcc ttc ctg tcc tcc ggc ttc agc cca gca gaa ctc ctg 7747 Ala Val Asp Ala Phe Leu Ser Ser Gly Phe Ser Pro Ala Glu Leu Leu 2535 2540 2545 cag tcc atc cac cca gct gac gtg tcc tcc acc cag ggc acc ggt atc 7795 Gln Ser Ile His Pro Ala Asp Val Ser Ser Thr Gln Gly Thr Gly Ile 2550 2555 2560 2565 ggt ggc atg cag tcc cta cgc aag ctg ttc gtc aac cgc ttc ctc ggc 7843 Gly Gly Met Gln Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly 2570 2575 2580 cag gat cgt cca tcc gac atc ctc cag gag acc ctg cca aac gtt gtg 7891 Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu Thr Leu Pro Asn Val Val 2585 2590 2595 gct gca cac acc atg cag tcc tac gtc ggt ggc tac ggc cag atg atc 7939 Ala Ala His Thr Met Gln Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile 2600 2605 2610 cac cca gtg gca gca tgt gca acc gca gct gtc tcc gtg gaa gaa ggc 7987 His Pro Val Ala Ala Cys Ala Thr Ala Ala Val Ser Val Glu Glu Gly 2615 2620 2625 gtg gac aag atc cgc ctc aac aag gca gat ttc gtt gtc gcc ggt ggt 8035 Val Asp Lys Ile Arg Leu Asn Lys Ala Asp Phe Val Val Ala Gly Gly 2630 2635 2640 2645 atc gat gac atc cag gtt gaa tcc ctg acc ggc ttc ggt gac atg aac 8083 Ile Asp Asp Ile Gln Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn 2650 2655 2660 gcc acc gca gac acc cag gca atg ctg gac aag ggc atc gac cca cgc 8131 Ala Thr Ala Asp Thr Gln Ala Met Leu Asp Lys Gly Ile Asp Pro Arg 2665 2670 2675 ttc atc tcc cgc gca aac gat cga cgt cgc gca ggc ttc ctc gaa gca 8179 Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg Ala Gly Phe Leu Glu Ala 2680 2685 2690 gca ggt ggc ggt acc gtc ctc ctg gca cgt gca tcc gtt gct gct gaa 8227 Ala Gly Gly Gly Thr Val Leu Leu Ala Arg Ala Ser Val Ala Ala Glu 2695 2700 2705 ctg gga ctg cca gtt ctc gca gtt gtt gca cac gca cag tcc tac gcc 8275 Leu Gly Leu Pro Val Leu Ala Val Val Ala His Ala Gln Ser Tyr Ala 2710 2715 2720 2725 gat ggt gct cac acc tcc atc cca gca ccg gga ctt ggc gca ctg ggt 8323 Asp Gly Ala His Thr Ser Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly 2730 2735 2740 gca gca cgt ggt ggc aag aag tcc gta ctt gct cgc gaa ctg aac aaa 8371 Ala Ala Arg Gly Gly Lys Lys Ser Val Leu Ala Arg Glu Leu Asn Lys 2745 2750 2755 ttg ggt ctg acc cca gat gac gtt cgc gtg gtc tcg aag cac gac acc 8419 Leu Gly Leu Thr Pro Asp Asp Val Arg Val Val Ser Lys His Asp Thr 2760 2765 2770 tcc acc aac gcc aac gat cca aac gag tcc gag ctg cac aac ctg ctg 8467 Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser Glu Leu His Asn Leu Leu 2775 2780 2785 tgg aag acc att gga cgc gaa gcc gac aac ccg atg ttc gtc gtc tcc 8515 Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn Pro Met Phe Val Val Ser 2790 2795 2800 2805 cag aag tcc ctt acc gga cac tca aag ggc ggt gca gca ctc ttc cag 8563 Gln Lys Ser Leu Thr Gly His Ser Lys Gly Gly Ala Ala Leu Phe Gln 2810 2815 2820 atc ggt gga ctt gtc tcc atc ctg gaa acc ggc aag ctg cca cag aac 8611 Ile Gly Gly Leu Val Ser Ile Leu Glu Thr Gly Lys Leu Pro Gln Asn 2825 2830 2835 gca tcc ctt gac tgc gtt gac cca gag atg gaa gca aag ggc gag aac 8659 Ala Ser Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn 2840 2845 2850 ttc gtc tgg ctg cgc aag cca ctg gat ctc ggc gca ggc tcc att aag 8707 Phe Val Trp Leu Arg Lys Pro Leu Asp Leu Gly Ala Gly Ser Ile Lys 2855 2860 2865 gcc ggc gta ctt acc tca ctg ggc ttc ggc cac gtg gct gca gtc gtc 8755 Ala Gly Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val 2870 2875 2880 2885 gtg ctg gca acc agc ggc atc ttc gag cag gca atg cgc aac gca ggc 8803 Val Leu Ala Thr Ser Gly Ile Phe Glu Gln Ala Met Arg Asn Ala Gly 2890 2895 2900 ctc gac gtc gaa gca tgg cgt gca cgc gca acc cag cgc ctg cgc acc 8851 Leu Asp Val Glu Ala Trp Arg Ala Arg Ala Thr Gln Arg Leu Arg Thr 2905 2910 2915 ggt gca aac cgc cta gaa gct ggc atg gtt ggc cga gca cca ttg ttc 8899 Gly Ala Asn Arg Leu Glu Ala Gly Met Val Gly Arg Ala Pro Leu Phe 2920 2925 2930 gag cag gtc gac gga cgt cgc ctg cca gag cat ggc gct cac caa gca 8947 Glu Gln Val Asp Gly Arg Arg Leu Pro Glu His Gly Ala His Gln Ala 2935 2940 2945 gag atc aac ttg ctt atc gac gct gac gct cgc ctc ggt gct gac ggc 8995 Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala Arg Leu Gly Ala Asp Gly 2950 2955 2960 2965 atc tac cag ggc taaacgttag atagctaaga aagctgcatt 9037 Ile Tyr Gln Gly <210> 180 <211> 2969 <212> PRT <213> Corynebacterium glutamicum <400> 180 Val Ser Ile Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala 1 5 10 15 Ile Leu Tyr Ala Gly Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp 20 25 30 Ser Ser Glu Asp His Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser 35 40 45 Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile 50 55 60 Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala 65 70 75 80 Gln Ile Gly Ala Asp Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly 85 90 95 Ile Leu Leu Gly Gln Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly 100 105 110 Leu Asp Val Ala Ala Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu 115 120 125 Gly Val Glu Ala Val Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile 130 135 140 Leu Leu Gly Ala Ala Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met 145 150 155 160 Leu Ser Val Arg Gly Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala 165 170 175 Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe 180 185 190 Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu 195 200 205 Gln Arg Ala Ala Asp Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys 210 215 220 Gly Gly Ser Leu Ala Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile 225 230 235 240 Pro Phe His His Ser Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu 245 250 255 Trp Ala Thr Thr Cys Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu 260 265 270 Ala Ile Leu Val Asn Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu 275 280 285 Lys Ala Asp Tyr Val Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr 290 295 300 Ala Pro Leu Leu Asp Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser 305 310 315 320 Ala Ala Glu Arg Asp Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr 325 330 335 Ala Glu Asp Trp Ser Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn 340 345 350 Gly Glu His Lys Val Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser 355 360 365 Pro Ile Val Leu Ala Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile 370 375 380 Val Ala Ala Ala Ala Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly 385 390 395 400 Gly Gln Tyr Ser Glu Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val 405 410 415 Ser Leu Leu Lys Val Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe 420 425 430 Asp Arg Tyr Met Trp Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser 435 440 445 Lys Ala Arg Ala Thr Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala 450 455 460 Gly Ile Pro Glu Val Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn 465 470 475 480 Ala Asp Gly Phe Pro Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln 485 490 495 Ile Arg Ala Thr Leu Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile 500 505 510 Ile Ile Gln Ile Glu Asp Gly His Ala Gly Gly His His Ser Trp Val 515 520 525 Asn Leu Asp Asp Leu Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg 530 535 540 Lys Asn Val Val Val Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys 545 550 555 560 Ala Ala Tyr Tyr Leu Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro 565 570 575 Ala Met Pro Val Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr 580 585 590 Lys Glu Ala Thr Thr Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr 595 600 605 Pro Gly Val Asp Pro His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp 610 615 620 Ala Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Ala Asp Met 625 630 635 640 Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser 645 650 655 Ile Asp Ser Asp Asp Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala 660 665 670 Ile Asn Lys Thr Ala Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr 675 680 685 Tyr Ala Glu Trp Ile Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln 690 695 700 Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu 705 710 715 720 Ala Arg Leu Asn Glu Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro 725 730 735 Asp His Ala Ser Val Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu 740 745 750 Ala Ala Tyr Pro Gln Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala 755 760 765 Ala Trp Phe Ile Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp 770 775 780 Val Pro Ala Ile Asp Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr 785 790 795 800 Leu Trp Gln Ser Gln Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val 805 810 815 Ile Pro Gly Pro Val Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro 820 825 830 Val Ala Glu Leu Leu Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu 835 840 845 Asp Gly Glu Pro Glu Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn 850 855 860 Glu Arg Glu Phe Leu Leu Ala Thr Pro His Ile Val Trp His Gly Asn 865 870 875 880 Leu Ile Asp Asn Pro Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu 885 890 895 Ile Glu Glu Asp Gly Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr 900 905 910 Phe Asp Asp Leu Pro Val Glu Gln Arg Pro Tyr Leu Val Gln His Val 915 920 925 Asp Ile Pro Val Glu Leu Gly Asp Ala Val Ala Thr Gly Gly Ser Pro 930 935 940 Val Val Ser Arg Glu Lys Leu Pro Glu Ser Val Phe Ala Leu Leu Ala 945 950 955 960 Gly Val Ala Gly Val Gly Ser Val Ser Ala Ala Gly Asp Glu Ile Lys 965 970 975 Ala Leu Pro Glu Ala Val Gln Asp Gly Thr Pro Phe Gly Thr Val Arg 980 985 990 Asp Ser Phe Thr Leu Pro Ala Ser Leu Leu Thr Ala His Thr Ala Val 995 1000 1005 Thr Gly Ala Ala Leu Glu Ala His Asn Val Gly Thr Pro Asp Val Leu 1010 1015 1020 Met Gly Ala Cys Trp Pro Ala Ile Tyr Ala Ala Leu Gly Thr Gly Lys 1025 1030 1035 1040 Leu Ser Asp Gly Tyr Pro Val Ile Glu Gly Leu Leu Asn Ala Val His 1045 1050 1055 Leu Asp His Leu Leu Asp Leu Arg Ile Pro Leu Glu Glu Leu Ala Asn 1060 1065 1070 Gly Arg Thr Ile Asp Val Glu Ala Arg Thr Asp Ser Ile Glu Glu Ser 1075 1080 1085 Ala Ser Gly Arg Ile Val Thr Val Arg Ile Val Leu Thr Thr Glu Gly 1090 1095 1100 Glu Val Ala Ala Lys Leu Val Thr Arg Phe Ala Ile Arg Gly Arg Ile 1105 1110 1115 1120 Thr Thr Asn Glu Met Ala Ala Pro Ala Asp Ser Tyr Gly Ala Arg Asp 1125 1130 1135 Glu Val Val Glu Ala Thr Pro Arg Ser Phe Ile Arg Gln Ala Thr Val 1140 1145 1150 Ser Ala Pro Ala Asp Met Thr Pro Phe Ala Met Val Ser Gly Asp Tyr 1155 1160 1165 Asn Pro Ile His Thr Ser Asp Asn Ala Ala Lys Leu Val Gly Leu Asp 1170 1175 1180 Ala Ala Leu Val His Gly Met Trp Leu Ser Ala Thr Ala Gln His Leu 1185 1190 1195 1200 Ala Gly Leu Gly Ser Glu Val Ile Gly Trp Thr Tyr Ser Met Tyr Gly 1205 1210 1215 Met Val Gln Leu Asn Asp Val Val Asp Ile Thr Val Glu Arg Val Gly 1220 1225 1230 Arg Ala Gly Leu Lys Pro Ala Tyr Glu Val Thr Cys Arg Ile Asp Gly 1235 1240 1245 Asn Val Val Ser Arg Gly Gln Ala Leu Leu Lys Ala Pro Ser Thr Ala 1250 1255 1260 Tyr Val Tyr Pro Ser Gln Gly Ile Gln Ala Lys Gly Met Gly Gln Gly 1265 1270 1275 1280 Asp Arg Thr Ala Ser Ala Glu Ala Arg Ala Val Trp Glu Arg Ala Asp 1285 1290 1295 Ala His Thr Arg Ala Asn Leu Gly Phe Ser Ile Gln Gln Val Ile Asp 1300 1305 1310 Glu Asn Pro Thr Glu Leu Lys Val Gly Asp Thr Thr Phe Val His Pro 1315 1320 1325 Ala Gly Val Leu Asn Leu Thr Gln Phe Thr Gln Val Ala Leu Ala Val 1330 1335 1340 Val Ala Tyr Ala Gln Thr Glu Arg Leu Lys Ala Ala Asn Ala Ile Val 1345 1350 1355 1360 Asp Gly Ser Leu Tyr Ala Gly His Ser Leu Gly Glu Tyr Thr Ala Leu 1365 1370 1375 Ala Ser Leu Gly Asn Ile Phe Glu Leu Glu Gly Val Ile Asp Val Val 1380 1385 1390 Phe Ser Arg Gly Ser Ala Met His Ser Leu Val Pro Arg Asp Glu Lys 1395 1400 1405 Gly Arg Ser Asn Tyr Gly Leu Ala Ala Phe Arg Pro Asn Met Ile Asn 1410 1415 1420 Val Ala Ala Thr Glu Val Glu Asn Trp Val Asp Arg Val Ala Glu Glu 1425 1430 1435 1440 Ser Gly Glu Phe Leu Gln Ile Val Asn Tyr Asn Val Asp Gly Gln Gln 1445 1450 1455 Tyr Ala Val Ala Gly Thr Leu Ala Gly Leu Lys Ala Leu Lys Ala Ser 1460 1465 1470 Ala Ser Ala Asn Pro Arg Ala Tyr Val Asn Ile Pro Gly Ile Asp Val 1475 1480 1485 Pro Phe His Ser Ser Val Leu Arg Pro Gly Val Pro Ala Phe Ala Glu 1490 1495 1500 Lys Leu Asp Glu Leu Leu Pro Glu Thr Ile Asp Ile Asp Ala Leu Arg 1505 1510 1515 1520 Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Gln 1525 1530 1535 Ser Phe Val Asp Ala Ile Leu Ala Val Val Pro Ser Glu Arg Leu Lys 1540 1545 1550 Gly Ile Lys Val Glu Asp Thr Asp Glu Asn Thr Leu Ala Arg Leu Leu 1555 1560 1565 Leu Ile Glu Leu Leu Ser Trp Gln Phe Ala Ser Pro Val Arg Trp Ile 1570 1575 1580 Glu Thr Gln Ala Leu Ile Ile Asp Thr Val Asp Gln Ile Ile Glu Val 1585 1590 1595 1600 Gly Leu Ala Ala Ser Pro Thr Leu Thr Asn Leu Ala Leu Arg Thr Met 1605 1610 1615 Asp Val Ile Gly Lys Ser Arg Pro Val Phe Asn Val Glu Arg Asp Gln 1620 1625 1630 Asp Thr Val Met Leu Asn Asp Val Arg Gln Ala Pro Val Ala Glu Val 1635 1640 1645 Glu Glu Glu Ala Val Glu Glu Ala Pro Ala Ala Ala Ala Ala Pro Ala 1650 1655 1660 Ala Glu Ala Pro Val Ala Ala Ala Pro Val Ala Ala Ala Ala Pro Ala 1665 1670 1675 1680 Pro Val Gly Asn Ala Pro Glu Leu Lys Phe Asn Ala Ala Asn Ala Ile 1685 1690 1695 Met Val Leu Phe Ala Val Gln Asn Lys Ile Asn Ile Asp Gln Ile Thr 1700 1705 1710 Ala Ala Asp Thr Ser Glu Thr Leu Thr Asn Gly Val Ser Ser Arg Arg 1715 1720 1725 Asn Gln Met Leu Met Asp Met Ser Thr Glu Leu Ser Val Pro Thr Ile 1730 1735 1740 Asp Gly Ala Ala Asp Ala Asp Val Ala Thr Leu Gln Gly Arg Val Val 1745 1750 1755 1760 Thr Ala Ala Pro Gly Tyr Lys Pro Phe Gly Pro Val Leu Ser Glu Thr 1765 1770 1775 Val Arg Ala Arg Leu Arg Ala Leu Thr Gly Ala Ala Gly Leu Lys Thr 1780 1785 1790 Ser Tyr Ile Gly Asp Arg Val Thr Gly Thr Trp Gly Leu Pro Glu Ser 1795 1800 1805 Trp Thr Ala His Val Glu Val Glu Leu Leu Leu Gly Thr Arg Glu Gly 1810 1815 1820 Glu Ser Val Arg Gly Gly Asn Leu Gly Ser Leu Pro Ala Asn Ala Ser 1825 1830 1835 1840 Ser Lys Gly Asp Val Asp Ala Leu Ile Asp Ala Ala Val Gln Asn Val 1845 1850 1855 Ala Ala Ala Asn Gly Thr Ser Val Ser Met Ser Ser Gly Gly Ala Ala 1860 1865 1870 Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala Ser 1875 1880 1885 Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly Ile 1890 1895 1900 Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala Glu 1905 1910 1915 1920 Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr Gly 1925 1930 1935 Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile Leu 1940 1945 1950 Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu Ala 1955 1960 1965 Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu Thr 1970 1975 1980 Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr Ala 1985 1990 1995 2000 Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro Ala 2005 2010 2015 Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala Pro 2020 2025 2030 Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly Ala 2035 2040 2045 Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu Tyr 2050 2055 2060 Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu Trp 2065 2070 2075 2080 Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val Ile 2085 2090 2095 Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val Thr 2100 2105 2110 Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala Ala 2115 2120 2125 Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu Asn 2130 2135 2140 Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly Leu 2145 2150 2155 2160 Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val Leu 2165 2170 2175 Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr Gly 2180 2185 2190 Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser Glu 2195 2200 2205 Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly Trp 2210 2215 2220 Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro Ala 2225 2230 2235 2240 Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser Ser 2245 2250 2255 Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu Glu 2260 2265 2270 Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val Ser 2275 2280 2285 Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr Thr 2290 2295 2300 Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His Pro 2305 2310 2315 2320 Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu Glu 2325 2330 2335 Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly Ser 2340 2345 2350 Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly Ser 2355 2360 2365 Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met Gly 2370 2375 2380 Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala Asp 2385 2390 2395 2400 Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp Glu 2405 2410 2415 Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe Leu 2420 2425 2430 Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg Asp 2435 2440 2445 Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val Asp 2450 2455 2460 Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile Val 2465 2470 2475 2480 Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr Leu 2485 2490 2495 Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala Lys 2500 2505 2510 Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala Ala 2515 2520 2525 Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe Ser 2530 2535 2540 Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser Thr 2545 2550 2555 2560 Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg Lys Leu Phe Val 2565 2570 2575 Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu Thr 2580 2585 2590 Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly Gly 2595 2600 2605 Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala Val 2610 2615 2620 Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp Phe 2625 2630 2635 2640 Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr Gly 2645 2650 2655 Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp Lys 2660 2665 2670 Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg Ala 2675 2680 2685 Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg Ala 2690 2695 2700 Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala His 2705 2710 2715 2720 Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro Gly 2725 2730 2735 Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu Ala 2740 2745 2750 Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val Val 2755 2760 2765 Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser Glu 2770 2775 2780 Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn Pro 2785 2790 2795 2800 Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly Gly 2805 2810 2815 Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr Gly 2820 2825 2830 Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met Glu 2835 2840 2845 Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu Gly 2850 2855 2860 Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly His 2865 2870 2875 2880 Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln Ala 2885 2890 2895 Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala Thr 2900 2905 2910 Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val Gly 2915 2920 2925 Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu His 2930 2935 2940 Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala Arg 2945 2950 2955 2960 Leu Gly Ala Asp Gly Ile Tyr Gln Gly 2965 <210> 181 <211> 1915 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1885) <223> RXA03393 <400> 181 taacagctat gtaaaagacc aggtcaggtt cgggtcggtt taggtacgaa acccattttt 60 cggtttgctt tccaggtttc cccaagtaaa ggtgagtttt atg act aca tct gac 115 Met Thr Thr Ser Asp 1 5 cca aat ccg aaa ccg ata gtg gag gat gct cag cca gag caa att acc 163 Pro Asn Pro Lys Pro Ile Val Glu Asp Ala Gln Pro Glu Gln Ile Thr 10 15 20 gca acc gaa gaa ctg gcg ggc ttg ctt gag aat cca act aac ctg gaa 211 Ala Thr Glu Glu Leu Ala Gly Leu Leu Glu Asn Pro Thr Asn Leu Glu 25 30 35 ggg aaa ctg gcc gac gcc gaa gag gaa att atc ctc gaa ggc gaa gac 259 Gly Lys Leu Ala Asp Ala Glu Glu Glu Ile Ile Leu Glu Gly Glu Asp 40 45 50 acc cag gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att 307 Thr Gln Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile 55 60 65 gtc cta gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc 355 Val Leu Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr 70 75 80 85 aac ttt gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg 403 Asn Phe Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp 90 95 100 gcc ttc att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc 451 Ala Phe Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile 105 110 115 gcc gct agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca 499 Ala Ala Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala 120 125 130 cca gag ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt 547 Pro Glu Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly 135 140 145 atg ggt att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc 595 Met Gly Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe 150 155 160 165 tac cgc aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct 643 Tyr Arg Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala 170 175 180 atg tcc acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac 691 Met Ser Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr 185 190 195 gca att gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt 739 Ala Ile Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg 200 205 210 aaa cag ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt 787 Lys Gln Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly 215 220 225 gca gaa gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc 835 Ala Glu Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala 230 235 240 245 acc gta ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att 883 Thr Val Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile 250 255 260 ggt gca ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg 931 Gly Ala Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp 265 270 275 acc atc gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc 979 Thr Ile Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser 280 285 290 gct att tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac 1027 Ala Ile Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn 295 300 305 atg gtt ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca 1075 Met Val Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro 310 315 320 325 acc gtg tcg att ttg aac ctg ctg cca ggt tct att ggc aac tac ctg 1123 Thr Val Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu 330 335 340 tcc aac ttc ttc caa atg gca ggc cgc act gcc atg agt gcc gac ggc 1171 Ser Asn Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly 345 350 355 aca gca ggt gag tgg cta ggt agc tgg acc atc ttc tac tgg gca tgg 1219 Thr Ala Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp 360 365 370 tgg atc tct tgg tca cca ttc gta gga atg ttc ttg gca cgt att tcc 1267 Trp Ile Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser 375 380 385 cgt ggc cgc tcc atc cgt gag ttc atc ctg ggc gtg ttg ctc gtc cca 1315 Arg Gly Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro 390 395 400 405 gca ggt gtg tcc acc gta tgg ttc tcc att ttt ggt ggc act gcg att 1363 Ala Gly Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile 410 415 420 gtc ttc gaa caa aat ggg gaa tcc att tgg ggt gat ggt gca gca gaa 1411 Val Phe Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu 425 430 435 gag cag ctt ttt gga ttg ctt cat gca ctt cca ggt ggg caa atc atg 1459 Glu Gln Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met 440 445 450 ggc atc atc gcc atg att ttg ctg ggt act ttc ttc att acc tct gct 1507 Gly Ile Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala 455 460 465 gac tct gct tcc acc gtc atg ggc acc atg agt cag cac ggc cag ctg 1555 Asp Ser Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu 470 475 480 485 gaa gcc aac aag tgg gtg aca gct gcc tgg ggt gtt gct acc gca gct 1603 Glu Ala Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala 490 495 500 att gga cta acg cta ttg ctt tct ggt ggt gac aat gcc ttg agc aac 1651 Ile Gly Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn 505 510 515 ttg caa aac gtc acc atc gtg gct gca aca cca ttc ttg ttt gtg gtt 1699 Leu Gln Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val 520 525 530 att gga ttg atg ttt gcg tta gtc aag gac tta agc aat gat gtg atc 1747 Ile Gly Leu Met Phe Ala Leu Val Lys Asp Leu Ser Asn Asp Val Ile 535 540 545 tac ctc gag tac cgt gag cag caa cgc ttc aac gcg cgc ctt gcc cgt 1795 Tyr Leu Glu Tyr Arg Glu Gln Gln Arg Phe Asn Ala Arg Leu Ala Arg 550 555 560 565 gaa cgt cgt gtt cac aat gaa cac cgc aag cgt gaa ctg gct gca aag 1843 Glu Arg Arg Val His Asn Glu His Arg Lys Arg Glu Leu Ala Ala Lys 570 575 580 cga cgc agg gag cgt aag gcg agt ggc gcg ggg aag cgt cga 1885 Arg Arg Arg Glu Arg Lys Ala Ser Gly Ala Gly Lys Arg Arg 585 590 595 taggcaattt ttaacccctg ataccccttt 1915 <210> 182 <211> 595 <212> PRT <213> Corynebacterium glutamicum <400> 182 Met Thr Thr Ser Asp Pro Asn Pro Lys Pro Ile Val Glu Asp Ala Gln 1 5 10 15 Pro Glu Gln Ile Thr Ala Thr Glu Glu Leu Ala Gly Leu Leu Glu Asn 20 25 30 Pro Thr Asn Leu Glu Gly Lys Leu Ala Asp Ala Glu Glu Glu Ile Ile 35 40 45 Leu Glu Gly Glu Asp Thr Gln Ala Ser Leu Asn Trp Ser Val Ile Val 50 55 60 Pro Ala Leu Val Ile Val Leu Ala Thr Val Val Trp Gly Ile Gly Phe 65 70 75 80 Lys Asp Ser Phe Thr Asn Phe Ala Ser Ser Ala Leu Ser Ala Val Val 85 90 95 Asp Asn Leu Gly Trp Ala Phe Ile Leu Phe Gly Thr Val Phe Val Phe 100 105 110 Phe Ile Val Val Ile Ala Ala Ser Lys Phe Gly Thr Ile Arg Leu Gly 115 120 125 Arg Ile Asp Glu Ala Pro Glu Phe Arg Thr Val Ser Trp Ile Ser Met 130 135 140 Met Phe Ala Ala Gly Met Gly Ile Gly Leu Met Phe Tyr Gly Thr Thr 145 150 155 160 Glu Pro Leu Thr Phe Tyr Arg Asn Gly Val Pro Gly His Asp Glu His 165 170 175 Asn Val Gly Val Ala Met Ser Thr Thr Met Phe His Trp Thr Leu His 180 185 190 Pro Trp Ala Ile Tyr Ala Ile Val Gly Leu Ala Ile Ala Tyr Ser Thr 195 200 205 Phe Arg Val Gly Arg Lys Gln Leu Leu Ser Ser Ala Phe Val Pro Leu 210 215 220 Ile Gly Glu Lys Gly Ala Glu Gly Trp Leu Gly Lys Leu Ile Asp Ile 225 230 235 240 Leu Ala Ile Ile Ala Thr Val Phe Gly Thr Ala Cys Ser Leu Gly Leu 245 250 255 Gly Ala Leu Gln Ile Gly Ala Gly Leu Ser Ala Ala Asn Ile Ile Glu 260 265 270 Asp Pro Ser Asp Trp Thr Ile Val Gly Ile Val Ser Val Leu Thr Leu 275 280 285 Ala Phe Ile Phe Ser Ala Ile Ser Gly Val Gly Lys Gly Ile Gln Tyr 290 295 300 Leu Ser Asn Ala Asn Met Val Leu Ala Ala Leu Leu Ala Ile Phe Val 305 310 315 320 Phe Val Val Gly Pro Thr Val Ser Ile Leu Asn Leu Leu Pro Gly Ser 325 330 335 Ile Gly Asn Tyr Leu Ser Asn Phe Phe Gln Met Ala Gly Arg Thr Ala 340 345 350 Met Ser Ala Asp Gly Thr Ala Gly Glu Trp Leu Gly Ser Trp Thr Ile 355 360 365 Phe Tyr Trp Ala Trp Trp Ile Ser Trp Ser Pro Phe Val Gly Met Phe 370 375 380 Leu Ala Arg Ile Ser Arg Gly Arg Ser Ile Arg Glu Phe Ile Leu Gly 385 390 395 400 Val Leu Leu Val Pro Ala Gly Val Ser Thr Val Trp Phe Ser Ile Phe 405 410 415 Gly Gly Thr Ala Ile Val Phe Glu Gln Asn Gly Glu Ser Ile Trp Gly 420 425 430 Asp Gly Ala Ala Glu Glu Gln Leu Phe Gly Leu Leu His Ala Leu Pro 435 440 445 Gly Gly Gln Ile Met Gly Ile Ile Ala Met Ile Leu Leu Gly Thr Phe 450 455 460 Phe Ile Thr Ser Ala Asp Ser Ala Ser Thr Val Met Gly Thr Met Ser 465 470 475 480 Gln His Gly Gln Leu Glu Ala Asn Lys Trp Val Thr Ala Ala Trp Gly 485 490 495 Val Ala Thr Ala Ala Ile Gly Leu Thr Leu Leu Leu Ser Gly Gly Asp 500 505 510 Asn Ala Leu Ser Asn Leu Gln Asn Val Thr Ile Val Ala Ala Thr Pro 515 520 525 Phe Leu Phe Val Val Ile Gly Leu Met Phe Ala Leu Val Lys Asp Leu 530 535 540 Ser Asn Asp Val Ile Tyr Leu Glu Tyr Arg Glu Gln Gln Arg Phe Asn 545 550 555 560 Ala Arg Leu Ala Arg Glu Arg Arg Val His Asn Glu His Arg Lys Arg 565 570 575 Glu Leu Ala Ala Lys Arg Arg Arg Glu Arg Lys Ala Ser Gly Ala Gly 580 585 590 Lys Arg Arg 595 <210> 183 <211> 433 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(403) <223> RXA03763 <400> 183 caccatcgat gcccaaccag atcaggtgtg ggaggtgttg agtgatctag agcccttccc 60 gcagtgacat cccaccatca cgtctttcag tggtgaagcg gtg gtt ggg aac acc 115 Val Val Gly Asn Thr 1 5 gtg gcg ttt aca aac aag gag ggg ggt tcg tcg ata agc tct act ccg 163 Val Ala Phe Thr Asn Lys Glu Gly Gly Ser Ser Ile Ser Ser Thr Pro 10 15 20 acc atc ctc gcg gcg gaa ccc gcc cgc gag ctg cgc tgg ctg gga cat 211 Thr Ile Leu Ala Ala Glu Pro Ala Arg Glu Leu Arg Trp Leu Gly His 25 30 35 gtg gcg ttt ccc ggg ctg atg gac ggc aac cat tcg ttt gtg ctg gag 259 Val Ala Phe Pro Gly Leu Met Asp Gly Asn His Ser Phe Val Leu Glu 40 45 50 cct gca ggc gag agc acg aag gtg acg cag tcg gag agt ttt acg ggg 307 Pro Ala Gly Glu Ser Thr Lys Val Thr Gln Ser Glu Ser Phe Thr Gly 55 60 65 att ctc ggg atg ttt gcc cca ctg ttt atg gat ttg ggg gca tca ttt 355 Ile Leu Gly Met Phe Ala Pro Leu Phe Met Asp Leu Gly Ala Ser Phe 70 75 80 85 gag gca tcc aat aaa gca ctt gca aat ttt gtg gag tct aaa gag cag 403 Glu Ala Ser Asn Lys Ala Leu Ala Asn Phe Val Glu Ser Lys Glu Gln 90 95 100 tgatttttcc cgatcccccc ctggccgcct 433 <210> 184 <211> 101 <212> PRT <213> Corynebacterium glutamicum <400> 184 Val Val Gly Asn Thr Val Ala Phe Thr Asn Lys Glu Gly Gly Ser Ser 1 5 10 15 Ile Ser Ser Thr Pro Thr Ile Leu Ala Ala Glu Pro Ala Arg Glu Leu 20 25 30 Arg Trp Leu Gly His Val Ala Phe Pro Gly Leu Met Asp Gly Asn His 35 40 45 Ser Phe Val Leu Glu Pro Ala Gly Glu Ser Thr Lys Val Thr Gln Ser 50 55 60 Glu Ser Phe Thr Gly Ile Leu Gly Met Phe Ala Pro Leu Phe Met Asp 65 70 75 80 Leu Gly Ala Ser Phe Glu Ala Ser Asn Lys Ala Leu Ala Asn Phe Val 85 90 95 Glu Ser Lys Glu Gln 100 <210> 185 <211> 562 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(532) <223> RXA03864 <400> 185 actcgcggaa ctcggtggct acggcccaga gcggcttgcc cccgtggatc gcctggacat 60 ttatagggag ctgctgtgtt tctaggtatt gtgtaacctc gtg tcc gaa aat ctt 115 Val Ser Glu Asn Leu 1 5 gat gtt acg atc gtc cga cca atg agc ctg aaa acc caa gct ttc cgg 163 Asp Val Thr Ile Val Arg Pro Met Ser Leu Lys Thr Gln Ala Phe Arg 10 15 20 ttc atc ctc acc ggt ggc ctc tca gcc atc gtg gac ctc ggc ctg ctg 211 Phe Ile Leu Thr Gly Gly Leu Ser Ala Ile Val Asp Leu Gly Leu Leu 25 30 35 tca ctt ttg cag cta gtg ttc ggc ctt ccc gta cct gtt gcc cgc acg 259 Ser Leu Leu Gln Leu Val Phe Gly Leu Pro Val Pro Val Ala Arg Thr 40 45 50 atc tcc ttc atc gcc ggc acc acc acc gcc tac atg atc aac cgc cgg 307 Ile Ser Phe Ile Ala Gly Thr Thr Thr Ala Tyr Met Ile Asn Arg Arg 55 60 65 tgg acc ttc caa gca gaa agc tcc acc tcc agg ttc ctt gct gtg gtg 355 Trp Thr Phe Gln Ala Glu Ser Ser Thr Ser Arg Phe Leu Ala Val Val 70 75 80 85 gcc ctc tac ggc gtg acc ttc ctg atc aac att gga ctg caa acc ctc 403 Ala Leu Tyr Gly Val Thr Phe Leu Ile Asn Ile Gly Leu Gln Thr Leu 90 95 100 tgc tcc gca ttg ttt gag aat tgg ggc tgg aac gaa gcc gtc gcg atg 451 Cys Ser Ala Leu Phe Glu Asn Trp Gly Trp Asn Glu Ala Val Ala Met 105 110 115 gtg gtc gcc ttc gtg atc gcc caa ggc acc gga acg gtc atc aac ttc 499 Val Val Ala Phe Val Ile Ala Gln Gly Thr Gly Thr Val Ile Asn Phe 120 125 130 atc gtc caa aga acc atc att ttc cga gtg aag taaggtaccc ctcatgaaga 552 Ile Val Gln Arg Thr Ile Ile Phe Arg Val Lys 135 140 ccttcaatcc 562 <210> 186 <211> 144 <212> PRT <213> Corynebacterium glutamicum <400> 186 Val Ser Glu Asn Leu Asp Val Thr Ile Val Arg Pro Met Ser Leu Lys 1 5 10 15 Thr Gln Ala Phe Arg Phe Ile Leu Thr Gly Gly Leu Ser Ala Ile Val 20 25 30 Asp Leu Gly Leu Leu Ser Leu Leu Gln Leu Val Phe Gly Leu Pro Val 35 40 45 Pro Val Ala Arg Thr Ile Ser Phe Ile Ala Gly Thr Thr Thr Ala Tyr 50 55 60 Met Ile Asn Arg Arg Trp Thr Phe Gln Ala Glu Ser Ser Thr Ser Arg 65 70 75 80 Phe Leu Ala Val Val Ala Leu Tyr Gly Val Thr Phe Leu Ile Asn Ile 85 90 95 Gly Leu Gln Thr Leu Cys Ser Ala Leu Phe Glu Asn Trp Gly Trp Asn 100 105 110 Glu Ala Val Ala Met Val Val Ala Phe Val Ile Ala Gln Gly Thr Gly 115 120 125 Thr Val Ile Asn Phe Ile Val Gln Arg Thr Ile Ile Phe Arg Val Lys 130 135 140 <210> 187 <211> 1621 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1591) <223> RXA03916 <400> 187 ttttacctat tggtgcgaag aatcagatcc accctattga tctgaacatt aaaacgaaat 60 gtagctaatt tagatcgcga atttatatgg aagaagaccg atg gca aat act aga 115 Met Ala Asn Thr Arg 1 5 gat gaa gct act gaa gta cct gaa gat ggc tct ttg agg aag ggc gca 163 Asp Glu Ala Thr Glu Val Pro Glu Asp Gly Ser Leu Arg Lys Gly Ala 10 15 20 gct cgg gga tcc gct atc act tta gta ggg cag att acg aga att ttg 211 Ala Arg Gly Ser Ala Ile Thr Leu Val Gly Gln Ile Thr Arg Ile Leu 25 30 35 att cag tta ctc agc gta atc tta cta gct aga tta att cct cct gca 259 Ile Gln Leu Leu Ser Val Ile Leu Leu Ala Arg Leu Ile Pro Pro Ala 40 45 50 gat ttt ggt tta tac gct atg gtc ctt gca gtt tca ggc gtg gct cag 307 Asp Phe Gly Leu Tyr Ala Met Val Leu Ala Val Ser Gly Val Ala Gln 55 60 65 atc ttt ctc gat cta ggg ttt tct atg gcg gcc ctg aga tca cgt gat 355 Ile Phe Leu Asp Leu Gly Phe Ser Met Ala Ala Leu Arg Ser Arg Asp 70 75 80 85 cta act aag caa caa cat tca aat cta ttt tgg att aat act tcc gct 403 Leu Thr Lys Gln Gln His Ser Asn Leu Phe Trp Ile Asn Thr Ser Ala 90 95 100 ggt ttt ctt cta ttt att att att ttt tca ctt gcg att cct tta gca 451 Gly Phe Leu Leu Phe Ile Ile Ile Phe Ser Leu Ala Ile Pro Leu Ala 105 110 115 act ttc tat gga gat gat cga tta ata agg gtt aca cag tgg ata tct 499 Thr Phe Tyr Gly Asp Asp Arg Leu Ile Arg Val Thr Gln Trp Ile Ser 120 125 130 att gtg tac ctg ttg ggg gga atc act gct cag ttt agg gtc cat tta 547 Ile Val Tyr Leu Leu Gly Gly Ile Thr Ala Gln Phe Arg Val His Leu 135 140 145 aat cgt cac ctg cga ttt gga gct tta tct ctt gca gat gtt tta gca 595 Asn Arg His Leu Arg Phe Gly Ala Leu Ser Leu Ala Asp Val Leu Ala 150 155 160 165 ccg ttg gta gct ctc gta gtg gcc gta att atg gca atg aag ggt tat 643 Pro Leu Val Ala Leu Val Val Ala Val Ile Met Ala Met Lys Gly Tyr 170 175 180 gga gtt caa gct ctt gtg gtt caa aca ata ttg aac tac tta gtt atg 691 Gly Val Gln Ala Leu Val Val Gln Thr Ile Leu Asn Tyr Leu Val Met 185 190 195 ctg gtt ttg gtt gtc gtg atg gcc cgg tgg gtt ccg agt ttt cct cgt 739 Leu Val Leu Val Val Val Met Ala Arg Trp Val Pro Ser Phe Pro Arg 200 205 210 aag act ccc ggt atg aag cca ttg ctt act ttt ggt atg gga ctt ggc 787 Lys Thr Pro Gly Met Lys Pro Leu Leu Thr Phe Gly Met Gly Leu Gly 215 220 225 gcg act aga ttc tta tct tat tta act caa aat att gat agt att att 835 Ala Thr Arg Phe Leu Ser Tyr Leu Thr Gln Asn Ile Asp Ser Ile Ile 230 235 240 245 att ggc cgg gtg atg ggg cca gtt cag ctc ggg ttt tat gat cgt gca 883 Ile Gly Arg Val Met Gly Pro Val Gln Leu Gly Phe Tyr Asp Arg Ala 250 255 260 ttt agg ctg gca gtc gca cct gtt gtg caa att agt ttc cca ttc aca 931 Phe Arg Leu Ala Val Ala Pro Val Val Gln Ile Ser Phe Pro Phe Thr 265 270 275 cgt gta gca ata cca ttt tta gtt cgt gta atg gat gat gga aaa aag 979 Arg Val Ala Ile Pro Phe Leu Val Arg Val Met Asp Asp Gly Lys Lys 280 285 290 tat gtt gcc gca cta cgt gaa gct caa atg gtc ggc atc tat gga act 1027 Tyr Val Ala Ala Leu Arg Glu Ala Gln Met Val Gly Ile Tyr Gly Thr 295 300 305 gct agt ttt ctt ttg gtt ttt ggc ggt atg gct aca cca att gtg acc 1075 Ala Ser Phe Leu Leu Val Phe Gly Gly Met Ala Thr Pro Ile Val Thr 310 315 320 325 tta att ttt ggt cct gat tgg gta gaa gcg gga ctt ctg atg aca att 1123 Leu Ile Phe Gly Pro Asp Trp Val Glu Ala Gly Leu Leu Met Thr Ile 330 335 340 cta tgc ata ggt gca ata ttc cgt aca ttg caa cag gtt gct act tgg 1171 Leu Cys Ile Gly Ala Ile Phe Arg Thr Leu Gln Gln Val Ala Thr Trp 345 350 355 gta ttt atg tca aaa gga ctg tcc ggg gca ttg ctg aag cta aat ctt 1219 Val Phe Met Ser Lys Gly Leu Ser Gly Ala Leu Leu Lys Leu Asn Leu 360 365 370 gtc atg caa ccg gtg atc gta ttg tta atc atc ggt ggt gct cga tgg 1267 Val Met Gln Pro Val Ile Val Leu Leu Ile Ile Gly Gly Ala Arg Trp 375 380 385 ggc acg gtt ggt gtt gca tgg gca ggg act ctg gga tac ttt ctg ttt 1315 Gly Thr Val Gly Val Ala Trp Ala Gly Thr Leu Gly Tyr Phe Leu Phe 390 395 400 405 tgg ttg gtc tca ata gct tgg gca agt tat gcc act aat tta aat ttg 1363 Trp Leu Val Ser Ile Ala Trp Ala Ser Tyr Ala Thr Asn Leu Asn Leu 410 415 420 tgg agt tta gtc aca aat cct cta gag att atc ggt aaa ttt agc ctt 1411 Trp Ser Leu Val Thr Asn Pro Leu Glu Ile Ile Gly Lys Phe Ser Leu 425 430 435 cct gcg ggg ctt att act ttt gcg att tcg tca aat tca tcc ctt tcg 1459 Pro Ala Gly Leu Ile Thr Phe Ala Ile Ser Ser Asn Ser Ser Leu Ser 440 445 450 cta tta aca cag ttc ttg gca tct att ggt ggt gca ttg att tgg ttt 1507 Leu Leu Thr Gln Phe Leu Ala Ser Ile Gly Gly Ala Leu Ile Trp Phe 455 460 465 gta ttc att tat tgc atc tca aag aag att aaa aaa gat att cgc cga 1555 Val Phe Ile Tyr Cys Ile Ser Lys Lys Ile Lys Lys Asp Ile Arg Arg 470 475 480 485 cta gtt gga atc gga atg cta gtt tta aag agg cgt tgaggggtag 1601 Leu Val Gly Ile Gly Met Leu Val Leu Lys Arg Arg 490 495 tatcgcgtaa gtttattagt 1621 <210> 188 <211> 497 <212> PRT <213> Corynebacterium glutamicum <400> 188 Met Ala Asn Thr Arg Asp Glu Ala Thr Glu Val Pro Glu Asp Gly Ser 1 5 10 15 Leu Arg Lys Gly Ala Ala Arg Gly Ser Ala Ile Thr Leu Val Gly Gln 20 25 30 Ile Thr Arg Ile Leu Ile Gln Leu Leu Ser Val Ile Leu Leu Ala Arg 35 40 45 Leu Ile Pro Pro Ala Asp Phe Gly Leu Tyr Ala Met Val Leu Ala Val 50 55 60 Ser Gly Val Ala Gln Ile Phe Leu Asp Leu Gly Phe Ser Met Ala Ala 65 70 75 80 Leu Arg Ser Arg Asp Leu Thr Lys Gln Gln His Ser Asn Leu Phe Trp 85 90 95 Ile Asn Thr Ser Ala Gly Phe Leu Leu Phe Ile Ile Ile Phe Ser Leu 100 105 110 Ala Ile Pro Leu Ala Thr Phe Tyr Gly Asp Asp Arg Leu Ile Arg Val 115 120 125 Thr Gln Trp Ile Ser Ile Val Tyr Leu Leu Gly Gly Ile Thr Ala Gln 130 135 140 Phe Arg Val His Leu Asn Arg His Leu Arg Phe Gly Ala Leu Ser Leu 145 150 155 160 Ala Asp Val Leu Ala Pro Leu Val Ala Leu Val Val Ala Val Ile Met 165 170 175 Ala Met Lys Gly Tyr Gly Val Gln Ala Leu Val Val Gln Thr Ile Leu 180 185 190 Asn Tyr Leu Val Met Leu Val Leu Val Val Val Met Ala Arg Trp Val 195 200 205 Pro Ser Phe Pro Arg Lys Thr Pro Gly Met Lys Pro Leu Leu Thr Phe 210 215 220 Gly Met Gly Leu Gly Ala Thr Arg Phe Leu Ser Tyr Leu Thr Gln Asn 225 230 235 240 Ile Asp Ser Ile Ile Ile Gly Arg Val Met Gly Pro Val Gln Leu Gly 245 250 255 Phe Tyr Asp Arg Ala Phe Arg Leu Ala Val Ala Pro Val Val Gln Ile 260 265 270 Ser Phe Pro Phe Thr Arg Val Ala Ile Pro Phe Leu Val Arg Val Met 275 280 285 Asp Asp Gly Lys Lys Tyr Val Ala Ala Leu Arg Glu Ala Gln Met Val 290 295 300 Gly Ile Tyr Gly Thr Ala Ser Phe Leu Leu Val Phe Gly Gly Met Ala 305 310 315 320 Thr Pro Ile Val Thr Leu Ile Phe Gly Pro Asp Trp Val Glu Ala Gly 325 330 335 Leu Leu Met Thr Ile Leu Cys Ile Gly Ala Ile Phe Arg Thr Leu Gln 340 345 350 Gln Val Ala Thr Trp Val Phe Met Ser Lys Gly Leu Ser Gly Ala Leu 355 360 365 Leu Lys Leu Asn Leu Val Met Gln Pro Val Ile Val Leu Leu Ile Ile 370 375 380 Gly Gly Ala Arg Trp Gly Thr Val Gly Val Ala Trp Ala Gly Thr Leu 385 390 395 400 Gly Tyr Phe Leu Phe Trp Leu Val Ser Ile Ala Trp Ala Ser Tyr Ala 405 410 415 Thr Asn Leu Asn Leu Trp Ser Leu Val Thr Asn Pro Leu Glu Ile Ile 420 425 430 Gly Lys Phe Ser Leu Pro Ala Gly Leu Ile Thr Phe Ala Ile Ser Ser 435 440 445 Asn Ser Ser Leu Ser Leu Leu Thr Gln Phe Leu Ala Ser Ile Gly Gly 450 455 460 Ala Leu Ile Trp Phe Val Phe Ile Tyr Cys Ile Ser Lys Lys Ile Lys 465 470 475 480 Lys Asp Ile Arg Arg Leu Val Gly Ile Gly Met Leu Val Leu Lys Arg 485 490 495 Arg <210> 189 <211> 1600 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1570) <223> RXA04102 <400> 189 cggcctaaag atctctgtag gaaacactcc cgccacagtc gctgggagtg tttcgtgctt 60 taaaaccaag aaccatgcaa aatggagaac tgtggcaaca atg gat gaa ttc tct 115 Met Asp Glu Phe Ser 1 5 cag gtc cct gac ggt gac caa cat ggc atc aga gac gac aaa aat ggc 163 Gln Val Pro Asp Gly Asp Gln His Gly Ile Arg Asp Asp Lys Asn Gly 10 15 20 gaa ccc gtt aag tct gcc agt gca gag ccg act cca agc aaa act tct 211 Glu Pro Val Lys Ser Ala Ser Ala Glu Pro Thr Pro Ser Lys Thr Ser 25 30 35 gct cgg cac cgg gat gca att gat cgc gta gac cgc tcg gtg gtc ata 259 Ala Arg His Arg Asp Ala Ile Asp Arg Val Asp Arg Ser Val Val Ile 40 45 50 ggt gat tac ttc aag agg gtg tcc atg tgg agt ttg cgg ttg gtg ttc 307 Gly Asp Tyr Phe Lys Arg Val Ser Met Trp Ser Leu Arg Leu Val Phe 55 60 65 gtc gcc gcc gct gtc ttt att tta tgg tgg gtc att ggt cgg ttc tgg 355 Val Ala Ala Ala Val Phe Ile Leu Trp Trp Val Ile Gly Arg Phe Trp 70 75 80 85 cag ggc gtt ttg ccg gtc acc ttg gca atc atc atc tgt act gtg ctg 403 Gln Gly Val Leu Pro Val Thr Leu Ala Ile Ile Ile Cys Thr Val Leu 90 95 100 tcc tca cca aac tca tgg ttg cgg aag cat gga gtt ccc agt gtg gtg 451 Ser Ser Pro Asn Ser Trp Leu Arg Lys His Gly Val Pro Ser Val Val 105 110 115 tcg gcg ttt atc acc atc ggc acg ttt ttt gcc gtc gtg ggt gct att 499 Ser Ala Phe Ile Thr Ile Gly Thr Phe Phe Ala Val Val Gly Ala Ile 120 125 130 ttg tgg tta att gcg ccg agt atc gcc caa caa tcc cag gtg ttg tac 547 Leu Trp Leu Ile Ala Pro Ser Ile Ala Gln Gln Ser Gln Val Leu Tyr 135 140 145 ttc cag gca ttt gag ggc att ttg agc att cag ctc tgg ctg cag ggt 595 Phe Gln Ala Phe Glu Gly Ile Leu Ser Ile Gln Leu Trp Leu Gln Gly 150 155 160 165 cca ccg ttg aac ttg gat tcg ggt gat ttg agc cgc tac ttc aac gag 643 Pro Pro Leu Asn Leu Asp Ser Gly Asp Leu Ser Arg Tyr Phe Asn Glu 170 175 180 gcc gcc gcg tgg ctg caa aac cag gca ggt gcc att gct gga gaa atc 691 Ala Ala Ala Trp Leu Gln Asn Gln Ala Gly Ala Ile Ala Gly Glu Ile 185 190 195 ttc tcg ggc ctg ggc gct gca acc agt gtg atc gtg acg ctt ggt gtg 739 Phe Ser Gly Leu Gly Ala Ala Thr Ser Val Ile Val Thr Leu Gly Val 200 205 210 gtg ttg gtg ctc aca ttc ttc ttc ctc aaa gac ggg cac cgg ttc ctc 787 Val Leu Val Leu Thr Phe Phe Phe Leu Lys Asp Gly His Arg Phe Leu 215 220 225 ccg tgg acc agg aag att ggt gga aag caa gct ggc tgg cac gtc acc 835 Pro Trp Thr Arg Lys Ile Gly Gly Lys Gln Ala Gly Trp His Val Thr 230 235 240 245 gag ctg ctc acc cgt gcg tgg acc acc ttg tct gga ttc gtc cgt gcg 883 Glu Leu Leu Thr Arg Ala Trp Thr Thr Leu Ser Gly Phe Val Arg Ala 250 255 260 cag gca ctg gtc tct gcg gtt gat gct gtg ttc att ggc atc ggt cta 931 Gln Ala Leu Val Ser Ala Val Asp Ala Val Phe Ile Gly Ile Gly Leu 265 270 275 ctt att gtg ggc gtt ccc atg gcg ttg gcg ctg tcg gtg att acc ttt 979 Leu Ile Val Gly Val Pro Met Ala Leu Ala Leu Ser Val Ile Thr Phe 280 285 290 gtt gct ggt ttc att ccc atc att ggt gcg ttc acc gca ggt gcg ttg 1027 Val Ala Gly Phe Ile Pro Ile Ile Gly Ala Phe Thr Ala Gly Ala Leu 295 300 305 gca gtg ctc gtg gca tta gtc tcg ctg ggc ttt acc gaa gcg gtc atc 1075 Ala Val Leu Val Ala Leu Val Ser Leu Gly Phe Thr Glu Ala Val Ile 310 315 320 325 gtg ctg gtt atc gtc gtg gca gtg cag cag ctg gag ggc aat att ttg 1123 Val Leu Val Ile Val Val Ala Val Gln Gln Leu Glu Gly Asn Ile Leu 330 335 340 tca cca ctg ttg cag tca aag gct atg aat ttg cac cct gtc atc gtg 1171 Ser Pro Leu Leu Gln Ser Lys Ala Met Asn Leu His Pro Val Ile Val 345 350 355 ttg ctg tcg gta act gtc ggt ggc acg ctc ttc ggc att gtc ggt gca 1219 Leu Leu Ser Val Thr Val Gly Gly Thr Leu Phe Gly Ile Val Gly Ala 360 365 370 ttc ttg gca gta cca gtg gct gcg atg att gct gta ttc ttc cgc tat 1267 Phe Leu Ala Val Pro Val Ala Ala Met Ile Ala Val Phe Phe Arg Tyr 375 380 385 ttc cag gac atg act tca cta cgt gct ggc gag aag gtg gct tct gat 1315 Phe Gln Asp Met Thr Ser Leu Arg Ala Gly Glu Lys Val Ala Ser Asp 390 395 400 405 ctg aag ttt gaa agc gaa tac ggc gag ttc gct ggc cgt gcc atg gaa 1363 Leu Lys Phe Glu Ser Glu Tyr Gly Glu Phe Ala Gly Arg Ala Met Glu 410 415 420 gcc gat ggt gaa atc ttc cgc agg cgc tac tac caa gac ttg ctt ggt 1411 Ala Asp Gly Glu Ile Phe Arg Arg Arg Tyr Tyr Gln Asp Leu Leu Gly 425 430 435 ggc gac gct gag acc aac gaa ctg aaa att cct gag ttt tta ggt gag 1459 Gly Asp Ala Glu Thr Asn Glu Leu Lys Ile Pro Glu Phe Leu Gly Glu 440 445 450 gat cgt gaa tcg gta gat cct aat gag gtt cgt cgt aaa gaa ttg aaa 1507 Asp Arg Glu Ser Val Asp Pro Asn Glu Val Arg Arg Lys Glu Leu Lys 455 460 465 cga cgg ttt acc tcg gca agg acg gca act tcg caa gca ttc gat aaa 1555 Arg Arg Phe Thr Ser Ala Arg Thr Ala Thr Ser Gln Ala Phe Asp Lys 470 475 480 485 ata cgc aag aga aac tgaggctcca taaaagctgc agaaactgca 1600 Ile Arg Lys Arg Asn 490 <210> 190 <211> 490 <212> PRT <213> Corynebacterium glutamicum <400> 190 Met Asp Glu Phe Ser Gln Val Pro Asp Gly Asp Gln His Gly Ile Arg 1 5 10 15 Asp Asp Lys Asn Gly Glu Pro Val Lys Ser Ala Ser Ala Glu Pro Thr 20 25 30 Pro Ser Lys Thr Ser Ala Arg His Arg Asp Ala Ile Asp Arg Val Asp 35 40 45 Arg Ser Val Val Ile Gly Asp Tyr Phe Lys Arg Val Ser Met Trp Ser 50 55 60 Leu Arg Leu Val Phe Val Ala Ala Ala Val Phe Ile Leu Trp Trp Val 65 70 75 80 Ile Gly Arg Phe Trp Gln Gly Val Leu Pro Val Thr Leu Ala Ile Ile 85 90 95 Ile Cys Thr Val Leu Ser Ser Pro Asn Ser Trp Leu Arg Lys His Gly 100 105 110 Val Pro Ser Val Val Ser Ala Phe Ile Thr Ile Gly Thr Phe Phe Ala 115 120 125 Val Val Gly Ala Ile Leu Trp Leu Ile Ala Pro Ser Ile Ala Gln Gln 130 135 140 Ser Gln Val Leu Tyr Phe Gln Ala Phe Glu Gly Ile Leu Ser Ile Gln 145 150 155 160 Leu Trp Leu Gln Gly Pro Pro Leu Asn Leu Asp Ser Gly Asp Leu Ser 165 170 175 Arg Tyr Phe Asn Glu Ala Ala Ala Trp Leu Gln Asn Gln Ala Gly Ala 180 185 190 Ile Ala Gly Glu Ile Phe Ser Gly Leu Gly Ala Ala Thr Ser Val Ile 195 200 205 Val Thr Leu Gly Val Val Leu Val Leu Thr Phe Phe Phe Leu Lys Asp 210 215 220 Gly His Arg Phe Leu Pro Trp Thr Arg Lys Ile Gly Gly Lys Gln Ala 225 230 235 240 Gly Trp His Val Thr Glu Leu Leu Thr Arg Ala Trp Thr Thr Leu Ser 245 250 255 Gly Phe Val Arg Ala Gln Ala Leu Val Ser Ala Val Asp Ala Val Phe 260 265 270 Ile Gly Ile Gly Leu Leu Ile Val Gly Val Pro Met Ala Leu Ala Leu 275 280 285 Ser Val Ile Thr Phe Val Ala Gly Phe Ile Pro Ile Ile Gly Ala Phe 290 295 300 Thr Ala Gly Ala Leu Ala Val Leu Val Ala Leu Val Ser Leu Gly Phe 305 310 315 320 Thr Glu Ala Val Ile Val Leu Val Ile Val Val Ala Val Gln Gln Leu 325 330 335 Glu Gly Asn Ile Leu Ser Pro Leu Leu Gln Ser Lys Ala Met Asn Leu 340 345 350 His Pro Val Ile Val Leu Leu Ser Val Thr Val Gly Gly Thr Leu Phe 355 360 365 Gly Ile Val Gly Ala Phe Leu Ala Val Pro Val Ala Ala Met Ile Ala 370 375 380 Val Phe Phe Arg Tyr Phe Gln Asp Met Thr Ser Leu Arg Ala Gly Glu 385 390 395 400 Lys Val Ala Ser Asp Leu Lys Phe Glu Ser Glu Tyr Gly Glu Phe Ala 405 410 415 Gly Arg Ala Met Glu Ala Asp Gly Glu Ile Phe Arg Arg Arg Tyr Tyr 420 425 430 Gln Asp Leu Leu Gly Gly Asp Ala Glu Thr Asn Glu Leu Lys Ile Pro 435 440 445 Glu Phe Leu Gly Glu Asp Arg Glu Ser Val Asp Pro Asn Glu Val Arg 450 455 460 Arg Lys Glu Leu Lys Arg Arg Phe Thr Ser Ala Arg Thr Ala Thr Ser 465 470 475 480 Gln Ala Phe Asp Lys Ile Arg Lys Arg Asn 485 490 <210> 191 <211> 1759 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1729) <223> RXA04164 <400> 191 atcgtcggtg cagtcctcgg attgcttaag ttgtaggtgg ctgggggcgt cgaaaagcag 60 ctttattgac ctggcaactt caatgataga ctgttaggtt gtg att gtc acc aat 115 Val Ile Val Thr Asn 1 5 gat tta gag gtg cgc gtt ggc gca cgt acc ctt ctc gat gcc cca ggt 163 Asp Leu Glu Val Arg Val Gly Ala Arg Thr Leu Leu Asp Ala Pro Gly 10 15 20 cag ctc ctt cgg gtg cag cca ggc gac cgt att ggt ctg gtt ggt aga 211 Gln Leu Leu Arg Val Gln Pro Gly Asp Arg Ile Gly Leu Val Gly Arg 25 30 35 aat ggt gcg ggc aaa acc acc acc atg cga atc ctc tcg ggc gaa acc 259 Asn Gly Ala Gly Lys Thr Thr Thr Met Arg Ile Leu Ser Gly Glu Thr 40 45 50 aag ccc tac gga gga tcc gta acc aca tct ggt gaa atc ggt tac ctg 307 Lys Pro Tyr Gly Gly Ser Val Thr Thr Ser Gly Glu Ile Gly Tyr Leu 55 60 65 ccc cag gac tcc cgc gaa ggc aac atc gaa caa acc gcc cgc gac cga 355 Pro Gln Asp Ser Arg Glu Gly Asn Ile Glu Gln Thr Ala Arg Asp Arg 70 75 80 85 gtc ctc tcc gcc cgt ggt ctt gac cag ctg cga tcc tcc atg gaa cgc 403 Val Leu Ser Ala Arg Gly Leu Asp Gln Leu Arg Ser Ser Met Glu Arg 90 95 100 cag cag gag atc atg gaa acc gcg acc gac ccc ggc aag ctc gac gcc 451 Gln Gln Glu Ile Met Glu Thr Ala Thr Asp Pro Gly Lys Leu Asp Ala 105 110 115 gcg atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc 499 Ala Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly 120 125 130 ggc tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc 547 Gly Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly 135 140 145 ctc gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc 595 Leu Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly 150 155 160 165 cag cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac 643 Gln Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn 170 175 180 ggc tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac 691 Gly Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn 185 190 195 cac ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag 739 His Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys 200 205 210 cac gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc 787 His Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly 215 220 225 gcc gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc 835 Ala Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala 230 235 240 245 gat gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc 883 Asp Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu 250 255 260 gat gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc 931 Asp Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala 265 270 275 gga gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag 979 Gly Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys 280 285 290 gct gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac 1027 Ala Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp 295 300 305 aac ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc 1075 Asn Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe 310 315 320 325 cca gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg 1123 Pro Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu 330 335 340 acc aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc 1171 Thr Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala 345 350 355 atc gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt 1219 Ile Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly 360 365 370 aaa acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc 1267 Lys Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly 375 380 385 gaa ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc 1315 Glu Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala 390 395 400 405 cag gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc 1363 Gln Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr 410 415 420 atc gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc 1411 Ile Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu 425 430 435 gga tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca 1459 Gly Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr 440 445 450 ctc tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc 1507 Leu Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser 455 460 465 tcc cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac 1555 Ser Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp 470 475 480 485 ccg atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc 1603 Pro Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly 490 495 500 gca gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag 1651 Ala Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu 505 510 515 cca gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat 1699 Pro Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn 520 525 530 gat cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1749 Asp Gln Tyr Met Glu Ile Val Glu Leu Ala 535 540 gctggtcaag 1759 <210> 192 <211> 543 <212> PRT <213> Corynebacterium glutamicum <400> 192 Val Ile Val Thr Asn Asp Leu Glu Val Arg Val Gly Ala Arg Thr Leu 1 5 10 15 Leu Asp Ala Pro Gly Gln Leu Leu Arg Val Gln Pro Gly Asp Arg Ile 20 25 30 Gly Leu Val Gly Arg Asn Gly Ala Gly Lys Thr Thr Thr Met Arg Ile 35 40 45 Leu Ser Gly Glu Thr Lys Pro Tyr Gly Gly Ser Val Thr Thr Ser Gly 50 55 60 Glu Ile Gly Tyr Leu Pro Gln Asp Ser Arg Glu Gly Asn Ile Glu Gln 65 70 75 80 Thr Ala Arg Asp Arg Val Leu Ser Ala Arg Gly Leu Asp Gln Leu Arg 85 90 95 Ser Ser Met Glu Arg Gln Gln Glu Ile Met Glu Thr Ala Thr Asp Pro 100 105 110 Gly Lys Leu Asp Ala Ala Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln 115 120 125 Phe Gln Ser Leu Gly Gly Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile 130 135 140 Cys Asp Asn Leu Gly Leu Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys 145 150 155 160 Thr Leu Ser Gly Gly Gln Arg Arg Arg Val Glu Leu Ala Gln Ile Leu 165 170 175 Phe Ala Ala Thr Asn Gly Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu 180 185 190 Asp Glu Pro Thr Asn His Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg 195 200 205 Asp Phe Leu Ala Lys His Glu Gly Gly Leu Ile Met Ile Ser His Asp 210 215 220 Val Glu Leu Leu Gly Ala Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala 225 230 235 240 Val Arg Ser Glu Ala Asp Val Tyr Asn Met Gly Phe Ser Lys Tyr Val 245 250 255 Asp Ala Arg Ala Leu Asp Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn 260 265 270 Ala Glu Lys Lys Ala Gly Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly 275 280 285 Ala Lys Ala Thr Lys Ala Ala Ala Ala Lys Gln Met Ile Ala Arg Ala 290 295 300 Glu Arg Met Ile Asp Asn Leu Asp Glu Ile Arg Val Ala Asp Arg Ala 305 310 315 320 Ala Asn Ile Val Phe Pro Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu 325 330 335 Asn Ala Lys Gly Leu Thr Lys Met Tyr Gly Ser Leu Glu Val Phe Ala 340 345 350 Gly Val Asp Leu Ala Ile Asp Lys Gly Ser Arg Val Val Val Leu Gly 355 360 365 Phe Asn Gly Ala Gly Lys Thr Thr Leu Leu Lys Leu Leu Ala Gly Val 370 375 380 Glu Arg Thr Asp Gly Glu Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys 385 390 395 400 Ile Gly Tyr Phe Ala Gln Glu His Asp Thr Ile Asp Pro Asp Lys Ser 405 410 415 Val Trp Gln Asn Thr Ile Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser 420 425 430 Leu Arg Ser Leu Leu Gly Ser Phe Met Phe Ser Gly Glu Gln Leu Asp 435 440 445 Gln Pro Ala Gly Thr Leu Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu 450 455 460 Ala Thr Leu Val Ser Ser Arg Ala Asn Val Leu Leu Leu Asp Glu Pro 465 470 475 480 Thr Asn Asn Leu Asp Pro Ile Ser Arg Glu Gln Val Leu Asp Ala Leu 485 490 495 Arg Thr Tyr Thr Gly Ala Val Val Leu Val Thr His Asp Pro Gly Ala 500 505 510 Val Lys Ala Leu Glu Pro Glu Arg Val Ile Val Leu Pro Asp Gly Thr 515 520 525 Glu Asp Leu Trp Asn Asp Gln Tyr Met Glu Ile Val Glu Leu Ala 530 535 540 <210> 193 <211> 2566 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2536) <223> RXA04275 <400> 193 tgttcatcgt agccgtaaag cattgagcag tgtcacaaaa ggtcacaagg tgcacagctc 60 agttccttaa aaaccgctgg atacggatac actatttttc atg cac ggt gaa aaa 115 Met His Gly Glu Lys 1 5 ctt gtg gat ggc act gag gga aat ctc agt caa ttc caa tgg cgc gat 163 Leu Val Asp Gly Thr Glu Gly Asn Leu Ser Gln Phe Gln Trp Arg Asp 10 15 20 atg gct aca aat cag acg ctg aga aaa gca ctg tta gtg ctt tct acc 211 Met Ala Thr Asn Gln Thr Leu Arg Lys Ala Leu Leu Val Leu Ser Thr 25 30 35 atc gct cta ctc ttg act tta tgg cct tca att ttc aat gtt cgg gcc 259 Ile Ala Leu Leu Leu Thr Leu Trp Pro Ser Ile Phe Asn Val Arg Ala 40 45 50 atc gag tct ttt gtt ttc ttc ttc cat att gat act gac gtg tac cgc 307 Ile Glu Ser Phe Val Phe Phe Phe His Ile Asp Thr Asp Val Tyr Arg 55 60 65 gcc ggt gct aat gca ttc ttg cat ggc gag aat ctg tat acc cag gac 355 Ala Gly Ala Asn Ala Phe Leu His Gly Glu Asn Leu Tyr Thr Gln Asp 70 75 80 85 tac caa gtt ggt agc att caa ctt ccc ttc acg tac cca ccg att tct 403 Tyr Gln Val Gly Ser Ile Gln Leu Pro Phe Thr Tyr Pro Pro Ile Ser 90 95 100 gct gcg ctg ttt gtt cca ctt gca atc ctt gca agc agt gta gcc gga 451 Ala Ala Leu Phe Val Pro Leu Ala Ile Leu Ala Ser Ser Val Ala Gly 105 110 115 ata gca tta acg ctt att tcc acg gtg ttg ctg tgg tgg agc gta gct 499 Ile Ala Leu Thr Leu Ile Ser Thr Val Leu Leu Trp Trp Ser Val Ala 120 125 130 atc gtc ttg cgc cga gtg ctc aag ggt ctc acg gat gct gat tcc agg 547 Ile Val Leu Arg Arg Val Leu Lys Gly Leu Thr Asp Ala Asp Ser Arg 135 140 145 ttt gtg tcc tat ttg att ctg cct atg gca ttg tcc acg gaa cct gta 595 Phe Val Ser Tyr Leu Ile Leu Pro Met Ala Leu Ser Thr Glu Pro Val 150 155 160 165 ttc cag acc ctg cag ttt ggc cag gtc aac atc att ttg atg gcg ctg 643 Phe Gln Thr Leu Gln Phe Gly Gln Val Asn Ile Ile Leu Met Ala Leu 170 175 180 gtt ctc atg gat acc ttc acc aaa aag ccc tgg ttg cca cgt ggt ttt 691 Val Leu Met Asp Thr Phe Thr Lys Lys Pro Trp Leu Pro Arg Gly Phe 185 190 195 tgg att ggt ttg gcg gca tcc atc aag ctg acc ccc gca gtc ttt ggc 739 Trp Ile Gly Leu Ala Ala Ser Ile Lys Leu Thr Pro Ala Val Phe Gly 200 205 210 ctt tac ttc cta gtg aag aag gac tgg aag ggc gct gga gta gca att 787 Leu Tyr Phe Leu Val Lys Lys Asp Trp Lys Gly Ala Gly Val Ala Ile 215 220 225 gct tct ggc gta ggt ttt tcc gcc ttg gcg ttt atc ctc tca cct tca 835 Ala Ser Gly Val Gly Phe Ser Ala Leu Ala Phe Ile Leu Ser Pro Ser 230 235 240 245 agt tcc aag att tac tgg act gaa aca ctc aac gac cct tct cgc atc 883 Ser Ser Lys Ile Tyr Trp Thr Glu Thr Leu Asn Asp Pro Ser Arg Ile 250 255 260 ggc aac cta tct tat att gct aac caa tct gtg cgt gga acg ctc agc 931 Gly Asn Leu Ser Tyr Ile Ala Asn Gln Ser Val Arg Gly Thr Leu Ser 265 270 275 cga atg atg cat gaa cag cag gat ctc gtc gaa aag ctt tgg ctt gtg 979 Arg Met Met His Glu Gln Gln Asp Leu Val Glu Lys Leu Trp Leu Val 280 285 290 gca gtt gtc ttg tgc ctt gcc gct gtc gcc gtc gcc atg tgg cgc gtg 1027 Ala Val Val Leu Cys Leu Ala Ala Val Ala Val Ala Met Trp Arg Val 295 300 305 gta cgc gcc ggc aac ccg tac ggc gcc gtc atg ctc aac tcg ttg att 1075 Val Arg Ala Gly Asn Pro Tyr Gly Ala Val Met Leu Asn Ser Leu Ile 310 315 320 325 gct ctg ctg tgc tcc cct gtt tca tgg tct cac cac tgg gta tgg ctg 1123 Ala Leu Leu Cys Ser Pro Val Ser Trp Ser His His Trp Val Trp Leu 330 335 340 att cca atc gct att ggt ttg ggg gca agt gcg tgg aac cag cgg cgg 1171 Ile Pro Ile Ala Ile Gly Leu Gly Ala Ser Ala Trp Asn Gln Arg Arg 345 350 355 act gct cca gga att gcc gcg acg gct gga gtc ttg gcg ctt ctg acc 1219 Thr Ala Pro Gly Ile Ala Ala Thr Ala Gly Val Leu Ala Leu Leu Thr 360 365 370 acg att ccg atg ttc atc aca aca ttt tgg aac atg cca tac gat tca 1267 Thr Ile Pro Met Phe Ile Thr Thr Phe Trp Asn Met Pro Tyr Asp Ser 375 380 385 gag tct tac cca ttt tgg cca ttg att ctg cag ccg tcg ggc aac gcg 1315 Glu Ser Tyr Pro Phe Trp Pro Leu Ile Leu Gln Pro Ser Gly Asn Ala 390 395 400 405 tat gta gta gtg gtc atc gct att ttg atc gtc gcg att gtg aat cca 1363 Tyr Val Val Val Val Ile Ala Ile Leu Ile Val Ala Ile Val Asn Pro 410 415 420 aca gtt ttg ggc agt ggc aat aaa gct gtt tca ggc cag gca gag aag 1411 Thr Val Leu Gly Ser Gly Asn Lys Ala Val Ser Gly Gln Ala Glu Lys 425 430 435 aag tcc tcc cct gcg ttg ctt gtt gtt tta gcg att gcc att ttc tac 1459 Lys Ser Ser Pro Ala Leu Leu Val Val Leu Ala Ile Ala Ile Phe Tyr 440 445 450 ctc ttt gcc aat att tgg ttt aag gga aac aat caa aac aaa gcg ctc 1507 Leu Phe Ala Asn Ile Trp Phe Lys Gly Asn Asn Gln Asn Lys Ala Leu 455 460 465 att cag tac cca ctg cag act atg gaa ggt cgc ggt ctc act gac ttc 1555 Ile Gln Tyr Pro Leu Gln Thr Met Glu Gly Arg Gly Leu Thr Asp Phe 470 475 480 485 ggc gag ctt att ttt gaa ttc gcg gct tcc tcc aac cag ctt gtt tcc 1603 Gly Glu Leu Ile Phe Glu Phe Ala Ala Ser Ser Asn Gln Leu Val Ser 490 495 500 ctc tgg ata atc ggc gcc ctc aac gcc atc gca ttg gct att acc ctg 1651 Leu Trp Ile Ile Gly Ala Leu Asn Ala Ile Ala Leu Ala Ile Thr Leu 505 510 515 tgg ttc ctc ctt cag cgt ttt gct ggg aag aag agc tcc tgg ctg att 1699 Trp Phe Leu Leu Gln Arg Phe Ala Gly Lys Lys Ser Ser Trp Leu Ile 520 525 530 tat ctc agc acc gtg gct gtt gcg ctg atg atg ttc tca gtg cag gat 1747 Tyr Leu Ser Thr Val Ala Val Ala Leu Met Met Phe Ser Val Gln Asp 535 540 545 gcc ttg cag ttt ggt tcg ctg act ctc gtt gca ctc gca ttg atc act 1795 Ala Leu Gln Phe Gly Ser Leu Thr Leu Val Ala Leu Ala Leu Ile Thr 550 555 560 565 gtt gat gtg ttg agt gtc aga gag att ggc cgc cgc ggg ctg ctc aca 1843 Val Asp Val Leu Ser Val Arg Glu Ile Gly Arg Arg Gly Leu Leu Thr 570 575 580 gga ctt gca gca gcc ctg ttt gga tgg cca att ctg att gtt atc gga 1891 Gly Leu Ala Ala Ala Leu Phe Gly Trp Pro Ile Leu Ile Val Ile Gly 585 590 595 ttc ctc att cac cga cgt tat gca gca aca atc aca acc act gtc acc 1939 Phe Leu Ile His Arg Arg Tyr Ala Ala Thr Ile Thr Thr Thr Val Thr 600 605 610 gca gct gtg ctg tgg atc tta gga att ctg ctc aat cca gac gcc ttc 1987 Ala Ala Val Leu Trp Ile Leu Gly Ile Leu Leu Asn Pro Asp Ala Phe 615 620 625 aac ctc aac ctg ctg cgt caa tgg ttc aac ggg cgc gat ggt cgg gac 2035 Asn Leu Asn Leu Leu Arg Gln Trp Phe Asn Gly Arg Asp Gly Arg Asp 630 635 640 645 aat ttg tcc ttc tat gct ttc ctt gcc agg tgg gtc agc gaa tcc cca 2083 Asn Leu Ser Phe Tyr Ala Phe Leu Ala Arg Trp Val Ser Glu Ser Pro 650 655 660 gtc atg atg ttc gta tgg ttc atc gtc gcc cta gga ctt ggt gcc tgg 2131 Val Met Met Phe Val Trp Phe Ile Val Ala Leu Gly Leu Gly Ala Trp 665 670 675 gca atc cac cgc acc tgg tca cat gga ttc aag gac ctc tcc gct gca 2179 Ala Ile His Arg Thr Trp Ser His Gly Phe Lys Asp Leu Ser Ala Ala 680 685 690 ctg agc atc gca cta cca acc ttg gtg ctc ccc ata gtg gaa ctc cac 2227 Leu Ser Ile Ala Leu Pro Thr Leu Val Leu Pro Ile Val Glu Leu His 695 700 705 cac ctc gtg cta ctt ctt cca ctg atc gca gtg ttg ctt cgt caa gga 2275 His Leu Val Leu Leu Leu Pro Leu Ile Ala Val Leu Leu Arg Gln Gly 710 715 720 725 cgc gtg gca att tcc tac ctc atc gga ttt atc tac cta gtc tca tgg 2323 Arg Val Ala Ile Ser Tyr Leu Ile Gly Phe Ile Tyr Leu Val Ser Trp 730 735 740 act ccg caa cac ctg tcc tac tcc acg gta ttc cca ctt aat gat cca 2371 Thr Pro Gln His Leu Ser Tyr Ser Thr Val Phe Pro Leu Asn Asp Pro 745 750 755 gca cca gaa ggg tac gtc gcc cac ttt gga tgg tat tta ctc gtt gaa 2419 Ala Pro Glu Gly Tyr Val Ala His Phe Gly Trp Tyr Leu Leu Val Glu 760 765 770 cca atg gcg gta gca ccg gca gct ata atc ctc gga gca ttt att gcc 2467 Pro Met Ala Val Ala Pro Ala Ala Ile Ile Leu Gly Ala Phe Ile Ala 775 780 785 tgt gct gca acc aca cct aaa aca agt cag ctc gtg cag gtc gac aag 2515 Cys Ala Ala Thr Thr Pro Lys Thr Ser Gln Leu Val Gln Val Asp Lys 790 795 800 805 tca agc gcg gaa aac acc aag taagccttac agtccgacag cctcatagcg 2566 Ser Ser Ala Glu Asn Thr Lys 810 <210> 194 <211> 812 <212> PRT <213> Corynebacterium glutamicum <400> 194 Met His Gly Glu Lys Leu Val Asp Gly Thr Glu Gly Asn Leu Ser Gln 1 5 10 15 Phe Gln Trp Arg Asp Met Ala Thr Asn Gln Thr Leu Arg Lys Ala Leu 20 25 30 Leu Val Leu Ser Thr Ile Ala Leu Leu Leu Thr Leu Trp Pro Ser Ile 35 40 45 Phe Asn Val Arg Ala Ile Glu Ser Phe Val Phe Phe Phe His Ile Asp 50 55 60 Thr Asp Val Tyr Arg Ala Gly Ala Asn Ala Phe Leu His Gly Glu Asn 65 70 75 80 Leu Tyr Thr Gln Asp Tyr Gln Val Gly Ser Ile Gln Leu Pro Phe Thr 85 90 95 Tyr Pro Pro Ile Ser Ala Ala Leu Phe Val Pro Leu Ala Ile Leu Ala 100 105 110 Ser Ser Val Ala Gly Ile Ala Leu Thr Leu Ile Ser Thr Val Leu Leu 115 120 125 Trp Trp Ser Val Ala Ile Val Leu Arg Arg Val Leu Lys Gly Leu Thr 130 135 140 Asp Ala Asp Ser Arg Phe Val Ser Tyr Leu Ile Leu Pro Met Ala Leu 145 150 155 160 Ser Thr Glu Pro Val Phe Gln Thr Leu Gln Phe Gly Gln Val Asn Ile 165 170 175 Ile Leu Met Ala Leu Val Leu Met Asp Thr Phe Thr Lys Lys Pro Trp 180 185 190 Leu Pro Arg Gly Phe Trp Ile Gly Leu Ala Ala Ser Ile Lys Leu Thr 195 200 205 Pro Ala Val Phe Gly Leu Tyr Phe Leu Val Lys Lys Asp Trp Lys Gly 210 215 220 Ala Gly Val Ala Ile Ala Ser Gly Val Gly Phe Ser Ala Leu Ala Phe 225 230 235 240 Ile Leu Ser Pro Ser Ser Ser Lys Ile Tyr Trp Thr Glu Thr Leu Asn 245 250 255 Asp Pro Ser Arg Ile Gly Asn Leu Ser Tyr Ile Ala Asn Gln Ser Val 260 265 270 Arg Gly Thr Leu Ser Arg Met Met His Glu Gln Gln Asp Leu Val Glu 275 280 285 Lys Leu Trp Leu Val Ala Val Val Leu Cys Leu Ala Ala Val Ala Val 290 295 300 Ala Met Trp Arg Val Val Arg Ala Gly Asn Pro Tyr Gly Ala Val Met 305 310 315 320 Leu Asn Ser Leu Ile Ala Leu Leu Cys Ser Pro Val Ser Trp Ser His 325 330 335 His Trp Val Trp Leu Ile Pro Ile Ala Ile Gly Leu Gly Ala Ser Ala 340 345 350 Trp Asn Gln Arg Arg Thr Ala Pro Gly Ile Ala Ala Thr Ala Gly Val 355 360 365 Leu Ala Leu Leu Thr Thr Ile Pro Met Phe Ile Thr Thr Phe Trp Asn 370 375 380 Met Pro Tyr Asp Ser Glu Ser Tyr Pro Phe Trp Pro Leu Ile Leu Gln 385 390 395 400 Pro Ser Gly Asn Ala Tyr Val Val Val Val Ile Ala Ile Leu Ile Val 405 410 415 Ala Ile Val Asn Pro Thr Val Leu Gly Ser Gly Asn Lys Ala Val Ser 420 425 430 Gly Gln Ala Glu Lys Lys Ser Ser Pro Ala Leu Leu Val Val Leu Ala 435 440 445 Ile Ala Ile Phe Tyr Leu Phe Ala Asn Ile Trp Phe Lys Gly Asn Asn 450 455 460 Gln Asn Lys Ala Leu Ile Gln Tyr Pro Leu Gln Thr Met Glu Gly Arg 465 470 475 480 Gly Leu Thr Asp Phe Gly Glu Leu Ile Phe Glu Phe Ala Ala Ser Ser 485 490 495 Asn Gln Leu Val Ser Leu Trp Ile Ile Gly Ala Leu Asn Ala Ile Ala 500 505 510 Leu Ala Ile Thr Leu Trp Phe Leu Leu Gln Arg Phe Ala Gly Lys Lys 515 520 525 Ser Ser Trp Leu Ile Tyr Leu Ser Thr Val Ala Val Ala Leu Met Met 530 535 540 Phe Ser Val Gln Asp Ala Leu Gln Phe Gly Ser Leu Thr Leu Val Ala 545 550 555 560 Leu Ala Leu Ile Thr Val Asp Val Leu Ser Val Arg Glu Ile Gly Arg 565 570 575 Arg Gly Leu Leu Thr Gly Leu Ala Ala Ala Leu Phe Gly Trp Pro Ile 580 585 590 Leu Ile Val Ile Gly Phe Leu Ile His Arg Arg Tyr Ala Ala Thr Ile 595 600 605 Thr Thr Thr Val Thr Ala Ala Val Leu Trp Ile Leu Gly Ile Leu Leu 610 615 620 Asn Pro Asp Ala Phe Asn Leu Asn Leu Leu Arg Gln Trp Phe Asn Gly 625 630 635 640 Arg Asp Gly Arg Asp Asn Leu Ser Phe Tyr Ala Phe Leu Ala Arg Trp 645 650 655 Val Ser Glu Ser Pro Val Met Met Phe Val Trp Phe Ile Val Ala Leu 660 665 670 Gly Leu Gly Ala Trp Ala Ile His Arg Thr Trp Ser His Gly Phe Lys 675 680 685 Asp Leu Ser Ala Ala Leu Ser Ile Ala Leu Pro Thr Leu Val Leu Pro 690 695 700 Ile Val Glu Leu His His Leu Val Leu Leu Leu Pro Leu Ile Ala Val 705 710 715 720 Leu Leu Arg Gln Gly Arg Val Ala Ile Ser Tyr Leu Ile Gly Phe Ile 725 730 735 Tyr Leu Val Ser Trp Thr Pro Gln His Leu Ser Tyr Ser Thr Val Phe 740 745 750 Pro Leu Asn Asp Pro Ala Pro Glu Gly Tyr Val Ala His Phe Gly Trp 755 760 765 Tyr Leu Leu Val Glu Pro Met Ala Val Ala Pro Ala Ala Ile Ile Leu 770 775 780 Gly Ala Phe Ile Ala Cys Ala Ala Thr Thr Pro Lys Thr Ser Gln Leu 785 790 795 800 Val Gln Val Asp Lys Ser Ser Ala Glu Asn Thr Lys 805 810 <210> 195 <211> 1438 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1408) <223> RXA04314 <400> 195 ttgttattgg tttgttcact cccatgcaat gtacgatcgg ttctaacgtc tacggcaatt 60 gacacgtcaa tttaattcag gaaaggggtg gggagaattt atg tct agt ggt ttt 115 Met Ser Ser Gly Phe 1 5 gaa tat gtt caa cat cct cga cga gcc ctc cct ccg cct ata cct gaa 163 Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro Pro Pro Ile Pro Glu 10 15 20 cgg aaa ggt cct gcc gca gca ttc ctg ccg gga act ttc cat ccc att 211 Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly Thr Phe His Pro Ile 25 30 35 aat cca aag aat att gca gcg agc cac gat cag gtg ctt cta tct ggt 259 Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln Val Leu Leu Ser Gly 40 45 50 tgg ggc aaa ttt gtg cgt tgg ctc ttg gta ttg ttg tcc att ttg gtc 307 Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu Leu Ser Ile Leu Val 55 60 65 atc atc att ggc atc aac ctc atc ttg gac ggt gtc tac gga ttt ggt 355 Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly Val Tyr Gly Phe Gly 70 75 80 85 act ttt tca acc acc cag atg tac caa gtt gcg aaa gat cca ctc att 403 Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala Lys Asp Pro Leu Ile 90 95 100 ggt gtg ctg atc ggt atc ttg gct acg gcc ttg gtg caa tca tca acc 451 Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu Val Gln Ser Ser Thr 105 110 115 acc acc aca acg ttg acg gtg act gca gtt ggt acg ggc att gtg tcg 499 Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly Thr Gly Ile Val Ser 120 125 130 gtg cct gtg gcg att ccg atc att ctt ggc gca aat atc ggt acg acg 547 Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala Asn Ile Gly Thr Thr 135 140 145 atc acc gcg atg ctc gtt gcg ttt tct tat gtg ggt gaa cgc agg gag 595 Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val Gly Glu Arg Arg Glu 150 155 160 165 ttt aag cga gct ttt acg gtt gcc gcc atg cat gtg tgg ttt aac gtg 643 Phe Lys Arg Ala Phe Thr Val Ala Ala Met His Val Trp Phe Asn Val 170 175 180 ctc gtc att ctt gtt cta ttt gtt gtg gaa ttg ctc ttt cat cca ttc 691 Leu Val Ile Leu Val Leu Phe Val Val Glu Leu Leu Phe His Pro Phe 185 190 195 cgc aca att agt ggt gcg atc gca acg gag atc aca ctg aca act ggt 739 Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile Thr Leu Thr Thr Gly 200 205 210 ggc tct ttg cct acc agt ggt gtg atg acc aag att ttt gat ccc cca 787 Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys Ile Phe Asp Pro Pro 215 220 225 acc caa ctt ctg ggt atg aat ggt ctt atc ggt tcg atc ggc aat cct 835 Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly Ser Ile Gly Asn Pro 230 235 240 245 agt att tcg gcg att gta tgt ctt gtg gtg ggc acc att ctt att ctg 883 Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly Thr Ile Leu Ile Leu 250 255 260 att tcg gtg cgt gcc atg agt tct cag atc cga acc att acg gca gcg 931 Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg Thr Ile Thr Ala Ala 265 270 275 acc gta acc tca att atg gac aag gtg atc aat cca gag aac agc ccc 979 Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn Pro Glu Asn Ser Pro 280 285 290 aag gcg acg att ctt tcc aat ttc tgg agc ttc att ctt gga gtt ttg 1027 Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe Ile Leu Gly Val Leu 295 300 305 ttc acg ctc atg gtc act gcc tcg tca gtg acc gtg gct tcc atg cag 1075 Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr Val Ala Ser Met Gln 310 315 320 325 cca gtg gct gcc tct ggt gtc gtt aag caa aag cca ttg ctg ggc gtc 1123 Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys Pro Leu Leu Gly Val 330 335 340 att ttg ggt gcc aac gtg ggc acc acg gtg acc gca atg ttt gct act 1171 Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr Ala Met Phe Ala Thr 345 350 355 ttc gcg att gtc agc gat cag ggt gag ttc gct att cag gct gcg ttg 1219 Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala Ile Gln Ala Ala Leu 360 365 370 atc cac ctc att gtg aac ttc acc ggc gca tta cta gtg ctg tgt att 1267 Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu Leu Val Leu Cys Ile 375 380 385 ccg cag ctt gcc aat gtg att att cac ttg gcc gag aaa act gcg aac 1315 Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala Glu Lys Thr Ala Asn 390 395 400 405 ctc act gcc cgc agt tac tcc atc acc ctg gcc aca att gta acg gcc 1363 Leu Thr Ala Arg Ser Tyr Ser Ile Thr Leu Ala Thr Ile Val Thr Ala 410 415 420 tat gtc ttg gtt cct tca gct gtg ttg atg att tac ttc ttc att 1408 Tyr Val Leu Val Pro Ser Ala Val Leu Met Ile Tyr Phe Phe Ile 425 430 435 taaaactctg ctgttccttg aaagatcgtg 1438 <210> 196 <211> 436 <212> PRT <213> Corynebacterium glutamicum <400> 196 Met Ser Ser Gly Phe Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro 1 5 10 15 Pro Pro Ile Pro Glu Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly 20 25 30 Thr Phe His Pro Ile Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln 35 40 45 Val Leu Leu Ser Gly Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu 50 55 60 Leu Ser Ile Leu Val Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly 65 70 75 80 Val Tyr Gly Phe Gly Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala 85 90 95 Lys Asp Pro Leu Ile Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu 100 105 110 Val Gln Ser Ser Thr Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly 115 120 125 Thr Gly Ile Val Ser Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala 130 135 140 Asn Ile Gly Thr Thr Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val 145 150 155 160 Gly Glu Arg Arg Glu Phe Lys Arg Ala Phe Thr Val Ala Ala Met His 165 170 175 Val Trp Phe Asn Val Leu Val Ile Leu Val Leu Phe Val Val Glu Leu 180 185 190 Leu Phe His Pro Phe Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile 195 200 205 Thr Leu Thr Thr Gly Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys 210 215 220 Ile Phe Asp Pro Pro Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly 225 230 235 240 Ser Ile Gly Asn Pro Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly 245 250 255 Thr Ile Leu Ile Leu Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg 260 265 270 Thr Ile Thr Ala Ala Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn 275 280 285 Pro Glu Asn Ser Pro Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe 290 295 300 Ile Leu Gly Val Leu Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr 305 310 315 320 Val Ala Ser Met Gln Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys 325 330 335 Pro Leu Leu Gly Val Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr 340 345 350 Ala Met Phe Ala Thr Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala 355 360 365 Ile Gln Ala Ala Leu Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu 370 375 380 Leu Val Leu Cys Ile Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala 385 390 395 400 Glu Lys Thr Ala Asn Leu Thr Ala Arg Ser Tyr Ser Ile Thr Leu Ala 405 410 415 Thr Ile Val Thr Ala Tyr Val Leu Val Pro Ser Ala Val Leu Met Ile 420 425 430 Tyr Phe Phe Ile 435 <210> 197 <211> 3187 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(3157) <223> RXA04323 <400> 197 tcgatgtgtg ttgctaactg ggggtggcac gcacgttggc gttgttgttt ggtgtggctc 60 cagagtaatc cacaacgcgc aaaggggaac tggagaacac gtg ctc att ctt ttt 115 Val Leu Ile Leu Phe 1 5 ctc gcg ctc act gca gcc gca gta gtc gcc ccc atc ctg atc cga act 163 Leu Ala Leu Thr Ala Ala Ala Val Val Ala Pro Ile Leu Ile Arg Thr 10 15 20 ctc ggt cga cca gct ttt ggt ctg ctg gcg ctt gta cct ggc att ggt 211 Leu Gly Arg Pro Ala Phe Gly Leu Leu Ala Leu Val Pro Gly Ile Gly 25 30 35 ttt ttc tgg gtg ctt tcg gag ttc atc aaa ggc act ttc aag gat gga 259 Phe Phe Trp Val Leu Ser Glu Phe Ile Lys Gly Thr Phe Lys Asp Gly 40 45 50 ggt gaa ctc ctc ctc cac tat gcc tgg atg cct tcg gct cac ctc aat 307 Gly Glu Leu Leu Leu His Tyr Ala Trp Met Pro Ser Ala His Leu Asn 55 60 65 atc gat ttc cgt atg gat tcc ctc gcg gcg ctg ttc tca ctc atc gtc 355 Ile Asp Phe Arg Met Asp Ser Leu Ala Ala Leu Phe Ser Leu Ile Val 70 75 80 85 tta ggc gtg ggc gcc cta gtg ctg ctg tac tgc tgg gga tat ttt gat 403 Leu Gly Val Gly Ala Leu Val Leu Leu Tyr Cys Trp Gly Tyr Phe Asp 90 95 100 tcc aac gcg ggt cgc ctc agt gcc ttt ggt gct gaa ctg gtg gcc ttc 451 Ser Asn Ala Gly Arg Leu Ser Ala Phe Gly Ala Glu Leu Val Ala Phe 105 110 115 gcc atg gcg atg ttt ggt ctt gtc att tca gac aac atc ctg ctg atg 499 Ala Met Ala Met Phe Gly Leu Val Ile Ser Asp Asn Ile Leu Leu Met 120 125 130 tac gtc ttc tgg gaa atc acc tcc gtt tta tcc ttc ctc ctg gtt ggt 547 Tyr Val Phe Trp Glu Ile Thr Ser Val Leu Ser Phe Leu Leu Val Gly 135 140 145 tat tac ggc gaa cgc gca tct tca cgt cgc tct gca ggt caa gcc ttg 595 Tyr Tyr Gly Glu Arg Ala Ser Ser Arg Arg Ser Ala Gly Gln Ala Leu 150 155 160 165 atg gtg acc acc ctg ggt gga ttg gcc atg ctg gtg ggc atc att ttg 643 Met Val Thr Thr Leu Gly Gly Leu Ala Met Leu Val Gly Ile Ile Leu 170 175 180 atg ggt acc caa act ggc gtg tgg cga ttc tct gag atc cct gcc tac 691 Met Gly Thr Gln Thr Gly Val Trp Arg Phe Ser Glu Ile Pro Ala Tyr 185 190 195 tca agc tcc tgg gca gat gtg ccg tat att tcc gct gct gct gcc ctt 739 Ser Ser Ser Trp Ala Asp Val Pro Tyr Ile Ser Ala Ala Ala Ala Leu 200 205 210 atc ttg gct ggc gca cta tcc aaa tcg gct atc gca cca acc cac ttc 787 Ile Leu Ala Gly Ala Leu Ser Lys Ser Ala Ile Ala Pro Thr His Phe 215 220 225 tgg ctt ccc ggc gcg atg gcc gca cca acg ccg gtg tct gct tac ctg 835 Trp Leu Pro Gly Ala Met Ala Ala Pro Thr Pro Val Ser Ala Tyr Leu 230 235 240 245 cac tcc gca gcg atg gtg aag gcg ggt att tac ctt gtg gct cgc ctc 883 His Ser Ala Ala Met Val Lys Ala Gly Ile Tyr Leu Val Ala Arg Leu 250 255 260 tct cca gac ctc aac gta gtt ggt tcg tgg tac ctg atc atc atc ccg 931 Ser Pro Asp Leu Asn Val Val Gly Ser Trp Tyr Leu Ile Ile Ile Pro 265 270 275 ttg ggc atg ttg acc atg ctc atg ggt ggt tgg atg gcg ctg cgc caa 979 Leu Gly Met Leu Thr Met Leu Met Gly Gly Trp Met Ala Leu Arg Gln 280 285 290 aag gat ctc aag ctg atc ctg gcg tac ggc acg gta tcc cag ttg ggc 1027 Lys Asp Leu Lys Leu Ile Leu Ala Tyr Gly Thr Val Ser Gln Leu Gly 295 300 305 ttc att att tcc gtg gtg ggc att ggt acc cgc gaa gct ttg ctg gca 1075 Phe Ile Ile Ser Val Val Gly Ile Gly Thr Arg Glu Ala Leu Leu Ala 310 315 320 325 ggt ctt gca ctg acc gtt gcg cac tcc ttg ttt aag gca aca ttg ttc 1123 Gly Leu Ala Leu Thr Val Ala His Ser Leu Phe Lys Ala Thr Leu Phe 330 335 340 atg aca gtt ggt gcc att gac cac acc acc gga act cgt gat att cgt 1171 Met Thr Val Gly Ala Ile Asp His Thr Thr Gly Thr Arg Asp Ile Arg 345 350 355 aaa ctc tcc ggt ctg tgg cgt aaa caa ccg atc ctg ttc gcc gtt gct 1219 Lys Leu Ser Gly Leu Trp Arg Lys Gln Pro Ile Leu Phe Ala Val Ala 360 365 370 gct gtt tcg gcg gcg tcc atg gct ggt att ccg cca ctg ttt ggt ttt 1267 Ala Val Ser Ala Ala Ser Met Ala Gly Ile Pro Pro Leu Phe Gly Phe 375 380 385 atc gcc aag gaa aca gcg ctg gat acc gtg ttg aat gag cag atg ttg 1315 Ile Ala Lys Glu Thr Ala Leu Asp Thr Val Leu Asn Glu Gln Met Leu 390 395 400 405 cat ggc atg cca ggt cga ttg atg ctg gct ggc atc gtt ttg ggt tcc 1363 His Gly Met Pro Gly Arg Leu Met Leu Ala Gly Ile Val Leu Gly Ser 410 415 420 atc ttc acc atg gca tat tcc tgc tac ttc ctg tac gaa gcc ttt gcc 1411 Ile Phe Thr Met Ala Tyr Ser Cys Tyr Phe Leu Tyr Glu Ala Phe Ala 425 430 435 acg aag cac tcc aaa ttc cca gag gcc aac ggt gtc tca cct gca gtg 1459 Thr Lys His Ser Lys Phe Pro Glu Ala Asn Gly Val Ser Pro Ala Val 440 445 450 gag gca atg cat ccg gtg aag ttt aag ctg tgg atc gca cct gtc atc 1507 Glu Ala Met His Pro Val Lys Phe Lys Leu Trp Ile Ala Pro Val Ile 455 460 465 ctg gct att ttg acc gta gtg ttt ggt gtt ttc ccc aag cca gtg tcg 1555 Leu Ala Ile Leu Thr Val Val Phe Gly Val Phe Pro Lys Pro Val Ser 470 475 480 485 gaa gca att gtc acg cat ctt gat aac gtc acg cca tcg ctt gat gat 1603 Glu Ala Ile Val Thr His Leu Asp Asn Val Thr Pro Ser Leu Asp Asp 490 495 500 gtc cac acc aaa ctg gcc ttg tgg cat ggt ctg aat cta ccg ctg ctg 1651 Val His Thr Lys Leu Ala Leu Trp His Gly Leu Asn Leu Pro Leu Leu 505 510 515 ctg tct gtg gtg atc atc att tcc gga ttc atc atc ttc tgg gag cga 1699 Leu Ser Val Val Ile Ile Ile Ser Gly Phe Ile Ile Phe Trp Glu Arg 520 525 530 gac acc gtc gaa cgt ttg cgc cct aac acc gca gcg ttt ggc agt gcc 1747 Asp Thr Val Glu Arg Leu Arg Pro Asn Thr Ala Ala Phe Gly Ser Ala 535 540 545 gat acc gcc tac gac gcc att ctt gat gca ctg cgt gtg ctc tcc cac 1795 Asp Thr Ala Tyr Asp Ala Ile Leu Asp Ala Leu Arg Val Leu Ser His 550 555 560 565 cgc ctg act gca tcc acc cag cgt ggt tct ttg acc ctg aac gtc ggt 1843 Arg Leu Thr Ala Ser Thr Gln Arg Gly Ser Leu Thr Leu Asn Val Gly 570 575 580 gtg atc ttc ttc gtc ctc acg att gtt ccg ctg atc gct ttg atc act 1891 Val Ile Phe Phe Val Leu Thr Ile Val Pro Leu Ile Ala Leu Ile Thr 585 590 595 ggc gaa caa agc gat gtc cgc atg gag ctg tgg gat agc cct att cag 1939 Gly Glu Gln Ser Asp Val Arg Met Glu Leu Trp Asp Ser Pro Ile Gln 600 605 610 ggc ttc atc gcg gcc atc att atc gtc gtt gcg att gtg gca acc acc 1987 Gly Phe Ile Ala Ala Ile Ile Ile Val Val Ala Ile Val Ala Thr Thr 615 620 625 atg gat aac cgt ttg tct gcg ctg att ttg gtg ggt gtg aca ggt tat 2035 Met Asp Asn Arg Leu Ser Ala Leu Ile Leu Val Gly Val Thr Gly Tyr 630 635 640 645 ggc att gcc gtt atc ttc gcg cta cat ggc gca ccg gac ttg gcg cta 2083 Gly Ile Ala Val Ile Phe Ala Leu His Gly Ala Pro Asp Leu Ala Leu 650 655 660 acc cag gtg ctg gtg gag acc atc gtc atg gtg gta ttc atg ctg gtg 2131 Thr Gln Val Leu Val Glu Thr Ile Val Met Val Val Phe Met Leu Val 665 670 675 ctg cgt aaa atg ccg aca gaa gtt gcg tgg aag gca gaa cct aaa cag 2179 Leu Arg Lys Met Pro Thr Glu Val Ala Trp Lys Ala Glu Pro Lys Gln 680 685 690 tct cgc gtg cga gcg tgg ctt gct ggc gcc acc gga ttg tcc gtt gtt 2227 Ser Arg Val Arg Ala Trp Leu Ala Gly Ala Thr Gly Leu Ser Val Val 695 700 705 att gtc acc att ttt gcc atg aat gct cgc acc act gaa ccg atc tct 2275 Ile Val Thr Ile Phe Ala Met Asn Ala Arg Thr Thr Glu Pro Ile Ser 710 715 720 725 gta tac atg cag gat ctg gcc tat gag atc gga cat ggc gca aac acc 2323 Val Tyr Met Gln Asp Leu Ala Tyr Glu Ile Gly His Gly Ala Asn Thr 730 735 740 gtc aac gta ctg ctc gta gac ctg cgt ggt ttt gat acc ttc ggt gaa 2371 Val Asn Val Leu Leu Val Asp Leu Arg Gly Phe Asp Thr Phe Gly Glu 745 750 755 att tcc gtc ctt gtg atc gcg gca acc ggt atc gcc tcc ctg gtc tac 2419 Ile Ser Val Leu Val Ile Ala Ala Thr Gly Ile Ala Ser Leu Val Tyr 760 765 770 cga aac cgc agc ttc cgc aag gat tct cgc aga cca acc ctg gct acc 2467 Arg Asn Arg Ser Phe Arg Lys Asp Ser Arg Arg Pro Thr Leu Ala Thr 775 780 785 act ggt cgc cgt tgg ttg gct gct gct gtt gat acc gaa agg gcg cag 2515 Thr Gly Arg Arg Trp Leu Ala Ala Ala Val Asp Thr Glu Arg Ala Gln 790 795 800 805 aac cgc tcg ctg atg gtt gat gtg gca acg cgc atc ctc ttc cct gcc 2563 Asn Arg Ser Leu Met Val Asp Val Ala Thr Arg Ile Leu Phe Pro Ala 810 815 820 atg atc atg ttg tct gtg tac ttc ttc ttc gcc gga cac aac gcg ccg 2611 Met Ile Met Leu Ser Val Tyr Phe Phe Phe Ala Gly His Asn Ala Pro 825 830 835 ggc ggc gga ttc gcc ggc ggc ctt gtt gcc tcc ttg gcg ttc gcc ttg 2659 Gly Gly Gly Phe Ala Gly Gly Leu Val Ala Ser Leu Ala Phe Ala Leu 840 845 850 cgc tac ctt gcc ggt gga cgt gaa gaa ctt gaa gaa gcg ttg cct atc 2707 Arg Tyr Leu Ala Gly Gly Arg Glu Glu Leu Glu Glu Ala Leu Pro Ile 855 860 865 gac gcc ggc cgt atc ttg gga act gga cta ttt gtt tct gca act gca 2755 Asp Ala Gly Arg Ile Leu Gly Thr Gly Leu Phe Val Ser Ala Thr Ala 870 875 880 885 gtg ctg tgg ccc atg gtt ctt ctt ggt gaa cca ccg ctg acc tcc cat 2803 Val Leu Trp Pro Met Val Leu Leu Gly Glu Pro Pro Leu Thr Ser His 890 895 900 att tgg gat ctc aca ctg cca ctt atc ggt gag att cac att gca tcc 2851 Ile Trp Asp Leu Thr Leu Pro Leu Ile Gly Glu Ile His Ile Ala Ser 905 910 915 gcg ctg ctc ttt gac ctt ggt gtc tac ctg atc gtc atc ggt ttg acc 2899 Ala Leu Leu Phe Asp Leu Gly Val Tyr Leu Ile Val Ile Gly Leu Thr 920 925 930 atg cac att ctc aac agt ttg ggc ggc cag ctc gac cgc gat gag gaa 2947 Met His Ile Leu Asn Ser Leu Gly Gly Gln Leu Asp Arg Asp Glu Glu 935 940 945 atg cgt aag cag cgt gcg cgc gac cga gct cga cgc ttg gcg cgc aac 2995 Met Arg Lys Gln Arg Ala Arg Asp Arg Ala Arg Arg Leu Ala Arg Asn 950 955 960 965 cag cgt cga gaa gca gca acc gtc ggc gca cgc agg tcg aac gag aaa 3043 Gln Arg Arg Glu Ala Ala Thr Val Gly Ala Arg Arg Ser Asn Glu Lys 970 975 980 tcg aca cgc caa atg ccg acg att cgg cct cca ggg gca gac aca gaa 3091 Ser Thr Arg Gln Met Pro Thr Ile Arg Pro Pro Gly Ala Asp Thr Glu 985 990 995 tcg gtg gag cag aac ggt gag aac cag acg tcg ata agc aca aag cgt 3139 Ser Val Glu Gln Asn Gly Glu Asn Gln Thr Ser Ile Ser Thr Lys Arg 1000 1005 1010 tta aag cag gaa gga aaa taacacatgg tagccaacct tttcctgctc 3187 Leu Lys Gln Glu Gly Lys 1015 <210> 198 <211> 1019 <212> PRT <213> Corynebacterium glutamicum <400> 198 Val Leu Ile Leu Phe Leu Ala Leu Thr Ala Ala Ala Val Val Ala Pro 1 5 10 15 Ile Leu Ile Arg Thr Leu Gly Arg Pro Ala Phe Gly Leu Leu Ala Leu 20 25 30 Val Pro Gly Ile Gly Phe Phe Trp Val Leu Ser Glu Phe Ile Lys Gly 35 40 45 Thr Phe Lys Asp Gly Gly Glu Leu Leu Leu His Tyr Ala Trp Met Pro 50 55 60 Ser Ala His Leu Asn Ile Asp Phe Arg Met Asp Ser Leu Ala Ala Leu 65 70 75 80 Phe Ser Leu Ile Val Leu Gly Val Gly Ala Leu Val Leu Leu Tyr Cys 85 90 95 Trp Gly Tyr Phe Asp Ser Asn Ala Gly Arg Leu Ser Ala Phe Gly Ala 100 105 110 Glu Leu Val Ala Phe Ala Met Ala Met Phe Gly Leu Val Ile Ser Asp 115 120 125 Asn Ile Leu Leu Met Tyr Val Phe Trp Glu Ile Thr Ser Val Leu Ser 130 135 140 Phe Leu Leu Val Gly Tyr Tyr Gly Glu Arg Ala Ser Ser Arg Arg Ser 145 150 155 160 Ala Gly Gln Ala Leu Met Val Thr Thr Leu Gly Gly Leu Ala Met Leu 165 170 175 Val Gly Ile Ile Leu Met Gly Thr Gln Thr Gly Val Trp Arg Phe Ser 180 185 190 Glu Ile Pro Ala Tyr Ser Ser Ser Trp Ala Asp Val Pro Tyr Ile Ser 195 200 205 Ala Ala Ala Ala Leu Ile Leu Ala Gly Ala Leu Ser Lys Ser Ala Ile 210 215 220 Ala Pro Thr His Phe Trp Leu Pro Gly Ala Met Ala Ala Pro Thr Pro 225 230 235 240 Val Ser Ala Tyr Leu His Ser Ala Ala Met Val Lys Ala Gly Ile Tyr 245 250 255 Leu Val Ala Arg Leu Ser Pro Asp Leu Asn Val Val Gly Ser Trp Tyr 260 265 270 Leu Ile Ile Ile Pro Leu Gly Met Leu Thr Met Leu Met Gly Gly Trp 275 280 285 Met Ala Leu Arg Gln Lys Asp Leu Lys Leu Ile Leu Ala Tyr Gly Thr 290 295 300 Val Ser Gln Leu Gly Phe Ile Ile Ser Val Val Gly Ile Gly Thr Arg 305 310 315 320 Glu Ala Leu Leu Ala Gly Leu Ala Leu Thr Val Ala His Ser Leu Phe 325 330 335 Lys Ala Thr Leu Phe Met Thr Val Gly Ala Ile Asp His Thr Thr Gly 340 345 350 Thr Arg Asp Ile Arg Lys Leu Ser Gly Leu Trp Arg Lys Gln Pro Ile 355 360 365 Leu Phe Ala Val Ala Ala Val Ser Ala Ala Ser Met Ala Gly Ile Pro 370 375 380 Pro Leu Phe Gly Phe Ile Ala Lys Glu Thr Ala Leu Asp Thr Val Leu 385 390 395 400 Asn Glu Gln Met Leu His Gly Met Pro Gly Arg Leu Met Leu Ala Gly 405 410 415 Ile Val Leu Gly Ser Ile Phe Thr Met Ala Tyr Ser Cys Tyr Phe Leu 420 425 430 Tyr Glu Ala Phe Ala Thr Lys His Ser Lys Phe Pro Glu Ala Asn Gly 435 440 445 Val Ser Pro Ala Val Glu Ala Met His Pro Val Lys Phe Lys Leu Trp 450 455 460 Ile Ala Pro Val Ile Leu Ala Ile Leu Thr Val Val Phe Gly Val Phe 465 470 475 480 Pro Lys Pro Val Ser Glu Ala Ile Val Thr His Leu Asp Asn Val Thr 485 490 495 Pro Ser Leu Asp Asp Val His Thr Lys Leu Ala Leu Trp His Gly Leu 500 505 510 Asn Leu Pro Leu Leu Leu Ser Val Val Ile Ile Ile Ser Gly Phe Ile 515 520 525 Ile Phe Trp Glu Arg Asp Thr Val Glu Arg Leu Arg Pro Asn Thr Ala 530 535 540 Ala Phe Gly Ser Ala Asp Thr Ala Tyr Asp Ala Ile Leu Asp Ala Leu 545 550 555 560 Arg Val Leu Ser His Arg Leu Thr Ala Ser Thr Gln Arg Gly Ser Leu 565 570 575 Thr Leu Asn Val Gly Val Ile Phe Phe Val Leu Thr Ile Val Pro Leu 580 585 590 Ile Ala Leu Ile Thr Gly Glu Gln Ser Asp Val Arg Met Glu Leu Trp 595 600 605 Asp Ser Pro Ile Gln Gly Phe Ile Ala Ala Ile Ile Ile Val Val Ala 610 615 620 Ile Val Ala Thr Thr Met Asp Asn Arg Leu Ser Ala Leu Ile Leu Val 625 630 635 640 Gly Val Thr Gly Tyr Gly Ile Ala Val Ile Phe Ala Leu His Gly Ala 645 650 655 Pro Asp Leu Ala Leu Thr Gln Val Leu Val Glu Thr Ile Val Met Val 660 665 670 Val Phe Met Leu Val Leu Arg Lys Met Pro Thr Glu Val Ala Trp Lys 675 680 685 Ala Glu Pro Lys Gln Ser Arg Val Arg Ala Trp Leu Ala Gly Ala Thr 690 695 700 Gly Leu Ser Val Val Ile Val Thr Ile Phe Ala Met Asn Ala Arg Thr 705 710 715 720 Thr Glu Pro Ile Ser Val Tyr Met Gln Asp Leu Ala Tyr Glu Ile Gly 725 730 735 His Gly Ala Asn Thr Val Asn Val Leu Leu Val Asp Leu Arg Gly Phe 740 745 750 Asp Thr Phe Gly Glu Ile Ser Val Leu Val Ile Ala Ala Thr Gly Ile 755 760 765 Ala Ser Leu Val Tyr Arg Asn Arg Ser Phe Arg Lys Asp Ser Arg Arg 770 775 780 Pro Thr Leu Ala Thr Thr Gly Arg Arg Trp Leu Ala Ala Ala Val Asp 785 790 795 800 Thr Glu Arg Ala Gln Asn Arg Ser Leu Met Val Asp Val Ala Thr Arg 805 810 815 Ile Leu Phe Pro Ala Met Ile Met Leu Ser Val Tyr Phe Phe Phe Ala 820 825 830 Gly His Asn Ala Pro Gly Gly Gly Phe Ala Gly Gly Leu Val Ala Ser 835 840 845 Leu Ala Phe Ala Leu Arg Tyr Leu Ala Gly Gly Arg Glu Glu Leu Glu 850 855 860 Glu Ala Leu Pro Ile Asp Ala Gly Arg Ile Leu Gly Thr Gly Leu Phe 865 870 875 880 Val Ser Ala Thr Ala Val Leu Trp Pro Met Val Leu Leu Gly Glu Pro 885 890 895 Pro Leu Thr Ser His Ile Trp Asp Leu Thr Leu Pro Leu Ile Gly Glu 900 905 910 Ile His Ile Ala Ser Ala Leu Leu Phe Asp Leu Gly Val Tyr Leu Ile 915 920 925 Val Ile Gly Leu Thr Met His Ile Leu Asn Ser Leu Gly Gly Gln Leu 930 935 940 Asp Arg Asp Glu Glu Met Arg Lys Gln Arg Ala Arg Asp Arg Ala Arg 945 950 955 960 Arg Leu Ala Arg Asn Gln Arg Arg Glu Ala Ala Thr Val Gly Ala Arg 965 970 975 Arg Ser Asn Glu Lys Ser Thr Arg Gln Met Pro Thr Ile Arg Pro Pro 980 985 990 Gly Ala Asp Thr Glu Ser Val Glu Gln Asn Gly Glu Asn Gln Thr Ser 995 1000 1005 Ile Ser Thr Lys Arg Leu Lys Gln Glu Gly Lys 1010 1015 <210> 199 <211> 1669 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1639) <223> RXA04359 <400> 199 cccggttcac gtgatcaatg acttcacgag caccgatgaa atcgatgctg cgcttcgtga 60 acgctacgac atctaactac tttaaaagga cgaaaatatt atg gac tgg tta acc 115 Met Asp Trp Leu Thr 1 5 att cct ctt ttc ctc gtt aat gaa atc ctt gcg gtt ccg gct ttc ctc 163 Ile Pro Leu Phe Leu Val Asn Glu Ile Leu Ala Val Pro Ala Phe Leu 10 15 20 atc ggt atc atc acc gcc gtg gga ttg ggt gcc atg ggg cgt tcc gtc 211 Ile Gly Ile Ile Thr Ala Val Gly Leu Gly Ala Met Gly Arg Ser Val 25 30 35 ggt cag gtt atc ggt gga gca atc aaa gca acg ttg ggc ttt ttg ctc 259 Gly Gln Val Ile Gly Gly Ala Ile Lys Ala Thr Leu Gly Phe Leu Leu 40 45 50 att ggt gcg ggt gcc acg ttg gtc act gcc tcc ctg gag cca ctg ggt 307 Ile Gly Ala Gly Ala Thr Leu Val Thr Ala Ser Leu Glu Pro Leu Gly 55 60 65 gcg atg atc atg ggt gcc aca ggc atg cgt ggt gtt gtc cca acg aat 355 Ala Met Ile Met Gly Ala Thr Gly Met Arg Gly Val Val Pro Thr Asn 70 75 80 85 gaa gcc atc gcc gga atc gca cag gct gaa tac ggc gcg cag gtg gcg 403 Glu Ala Ile Ala Gly Ile Ala Gln Ala Glu Tyr Gly Ala Gln Val Ala 90 95 100 tgg ctg atg att ctg ggc ttc gcc atc tct ttg gtg ttg gct cgt ttc 451 Trp Leu Met Ile Leu Gly Phe Ala Ile Ser Leu Val Leu Ala Arg Phe 105 110 115 acc aac ctg cgt tat gtc ttc ctc acc gga cac cac gtg ctg ttc atg 499 Thr Asn Leu Arg Tyr Val Phe Leu Thr Gly His His Val Leu Phe Met 120 125 130 tcc acc atg ctc acc atc atc ttg gcc acc gcc gga ttt gat gcg tgg 547 Ser Thr Met Leu Thr Ile Ile Leu Ala Thr Ala Gly Phe Asp Ala Trp 135 140 145 att gtg gtg ggt gtg ggt gct ctc ttg ctc ggt att ctc atg gtg tcg 595 Ile Val Val Gly Val Gly Ala Leu Leu Leu Gly Ile Leu Met Val Ser 150 155 160 165 ttg cct gcg ttc gcg cat ccg tgg act cgc cga atc act ggc gat gat 643 Leu Pro Ala Phe Ala His Pro Trp Thr Arg Arg Ile Thr Gly Asp Asp 170 175 180 tcc att gcc att gga cac ttc ggc acc gca ggt tat gta gct gcc ggt 691 Ser Ile Ala Ile Gly His Phe Gly Thr Ala Gly Tyr Val Ala Ala Gly 185 190 195 gca gtc ggc cga ctg gtc ggt ggc aag ggc aag aag gcc agc cct tcc 739 Ala Val Gly Arg Leu Val Gly Gly Lys Gly Lys Lys Ala Ser Pro Ser 200 205 210 act gag gat atg aag gtt ccg gaa ggc ttg cgc ttc ctc cgc gac tcc 787 Thr Glu Asp Met Lys Val Pro Glu Gly Leu Arg Phe Leu Arg Asp Ser 215 220 225 atg gtt tct aca gct ctg tcc atg gcg atc atg tac atc att ttg gct 835 Met Val Ser Thr Ala Leu Ser Met Ala Ile Met Tyr Ile Ile Leu Ala 230 235 240 245 att ttg ttc ctg gtg cgc gca gga gaa gaa gaa gcc ttc act gca ttc 883 Ile Leu Phe Leu Val Arg Ala Gly Glu Glu Glu Ala Phe Thr Ala Phe 250 255 260 ccc aat ggc gcc acc aac gta ggc aac tac atc atg cag tcc ttc act 931 Pro Asn Gly Ala Thr Asn Val Gly Asn Tyr Ile Met Gln Ser Phe Thr 265 270 275 caa ggt ctg cag ttc ggc gtt gca gtt gcc gtg att ctc ttt ggt gtc 979 Gln Gly Leu Gln Phe Gly Val Ala Val Ala Val Ile Leu Phe Gly Val 280 285 290 cgc acc att ctt ggt gaa ctg gtc ccc gca ttc caa ggt att gct gcg 1027 Arg Thr Ile Leu Gly Glu Leu Val Pro Ala Phe Gln Gly Ile Ala Ala 295 300 305 aag gtt gtt ccc gga gct atc ccc gca ttg gat gca ccg atc gtg ttc 1075 Lys Val Val Pro Gly Ala Ile Pro Ala Leu Asp Ala Pro Ile Val Phe 310 315 320 325 ccc tac gcg cag aac gcc gtt ctc att ggt ttc ttg tct tcc ttc gtc 1123 Pro Tyr Ala Gln Asn Ala Val Leu Ile Gly Phe Leu Ser Ser Phe Val 330 335 340 ggt ggc ttg gtt ggc ctg act gtt ctt gca tcg tgg ctg aac cca gct 1171 Gly Gly Leu Val Gly Leu Thr Val Leu Ala Ser Trp Leu Asn Pro Ala 345 350 355 ttt ggt gtc gcg ttg att ctg cct ggt ttg gtc ccc cac ttc ttc act 1219 Phe Gly Val Ala Leu Ile Leu Pro Gly Leu Val Pro His Phe Phe Thr 360 365 370 ggt ggc gcg gcg ggc gtt tac ggt aat gcc acg ggt ggt cgt cga gga 1267 Gly Gly Ala Ala Gly Val Tyr Gly Asn Ala Thr Gly Gly Arg Arg Gly 375 380 385 gca gta ttt ggc gcc ttt gcc aac ggt ctt ctg att acc ttc ctc cct 1315 Ala Val Phe Gly Ala Phe Ala Asn Gly Leu Leu Ile Thr Phe Leu Pro 390 395 400 405 gct ttc ctg ctt ggt gtg ctt ggt tcc ttc ggg tca gag aac acc act 1363 Ala Phe Leu Leu Gly Val Leu Gly Ser Phe Gly Ser Glu Asn Thr Thr 410 415 420 ttc ggt gat gcg gac ttt ggt tgg ttc gga atc gtt gtt ggt tct gca 1411 Phe Gly Asp Ala Asp Phe Gly Trp Phe Gly Ile Val Val Gly Ser Ala 425 430 435 gcc aag gtg gaa ggt gct ggc ggg ctc atc ttg ttg ctc atc atc gca 1459 Ala Lys Val Glu Gly Ala Gly Gly Leu Ile Leu Leu Leu Ile Ile Ala 440 445 450 gcg gtt ctt ctg ggt ggc gcg atg gtc ttc cag aag cgc gtc gtg aat 1507 Ala Val Leu Leu Gly Gly Ala Met Val Phe Gln Lys Arg Val Val Asn 455 460 465 ggg cac tgg gat cca gct ccc aac cgt gag cgc gtg gag aag gcg gaa 1555 Gly His Trp Asp Pro Ala Pro Asn Arg Glu Arg Val Glu Lys Ala Glu 470 475 480 485 gct gat gcc act cca acg gct ggg gct cgg acc tac cct aag att gct 1603 Ala Asp Ala Thr Pro Thr Ala Gly Ala Arg Thr Tyr Pro Lys Ile Ala 490 495 500 cct ccg gcg ggc gct cct acc cca ccg gct cga agc taagatctcc 1649 Pro Pro Ala Gly Ala Pro Thr Pro Pro Ala Arg Ser 505 510 aaaaccctga gatttcctaa 1669 <210> 200 <211> 513 <212> PRT <213> Corynebacterium glutamicum <400> 200 Met Asp Trp Leu Thr Ile Pro Leu Phe Leu Val Asn Glu Ile Leu Ala 1 5 10 15 Val Pro Ala Phe Leu Ile Gly Ile Ile Thr Ala Val Gly Leu Gly Ala 20 25 30 Met Gly Arg Ser Val Gly Gln Val Ile Gly Gly Ala Ile Lys Ala Thr 35 40 45 Leu Gly Phe Leu Leu Ile Gly Ala Gly Ala Thr Leu Val Thr Ala Ser 50 55 60 Leu Glu Pro Leu Gly Ala Met Ile Met Gly Ala Thr Gly Met Arg Gly 65 70 75 80 Val Val Pro Thr Asn Glu Ala Ile Ala Gly Ile Ala Gln Ala Glu Tyr 85 90 95 Gly Ala Gln Val Ala Trp Leu Met Ile Leu Gly Phe Ala Ile Ser Leu 100 105 110 Val Leu Ala Arg Phe Thr Asn Leu Arg Tyr Val Phe Leu Thr Gly His 115 120 125 His Val Leu Phe Met Ser Thr Met Leu Thr Ile Ile Leu Ala Thr Ala 130 135 140 Gly Phe Asp Ala Trp Ile Val Val Gly Val Gly Ala Leu Leu Leu Gly 145 150 155 160 Ile Leu Met Val Ser Leu Pro Ala Phe Ala His Pro Trp Thr Arg Arg 165 170 175 Ile Thr Gly Asp Asp Ser Ile Ala Ile Gly His Phe Gly Thr Ala Gly 180 185 190 Tyr Val Ala Ala Gly Ala Val Gly Arg Leu Val Gly Gly Lys Gly Lys 195 200 205 Lys Ala Ser Pro Ser Thr Glu Asp Met Lys Val Pro Glu Gly Leu Arg 210 215 220 Phe Leu Arg Asp Ser Met Val Ser Thr Ala Leu Ser Met Ala Ile Met 225 230 235 240 Tyr Ile Ile Leu Ala Ile Leu Phe Leu Val Arg Ala Gly Glu Glu Glu 245 250 255 Ala Phe Thr Ala Phe Pro Asn Gly Ala Thr Asn Val Gly Asn Tyr Ile 260 265 270 Met Gln Ser Phe Thr Gln Gly Leu Gln Phe Gly Val Ala Val Ala Val 275 280 285 Ile Leu Phe Gly Val Arg Thr Ile Leu Gly Glu Leu Val Pro Ala Phe 290 295 300 Gln Gly Ile Ala Ala Lys Val Val Pro Gly Ala Ile Pro Ala Leu Asp 305 310 315 320 Ala Pro Ile Val Phe Pro Tyr Ala Gln Asn Ala Val Leu Ile Gly Phe 325 330 335 Leu Ser Ser Phe Val Gly Gly Leu Val Gly Leu Thr Val Leu Ala Ser 340 345 350 Trp Leu Asn Pro Ala Phe Gly Val Ala Leu Ile Leu Pro Gly Leu Val 355 360 365 Pro His Phe Phe Thr Gly Gly Ala Ala Gly Val Tyr Gly Asn Ala Thr 370 375 380 Gly Gly Arg Arg Gly Ala Val Phe Gly Ala Phe Ala Asn Gly Leu Leu 385 390 395 400 Ile Thr Phe Leu Pro Ala Phe Leu Leu Gly Val Leu Gly Ser Phe Gly 405 410 415 Ser Glu Asn Thr Thr Phe Gly Asp Ala Asp Phe Gly Trp Phe Gly Ile 420 425 430 Val Val Gly Ser Ala Ala Lys Val Glu Gly Ala Gly Gly Leu Ile Leu 435 440 445 Leu Leu Ile Ile Ala Ala Val Leu Leu Gly Gly Ala Met Val Phe Gln 450 455 460 Lys Arg Val Val Asn Gly His Trp Asp Pro Ala Pro Asn Arg Glu Arg 465 470 475 480 Val Glu Lys Ala Glu Ala Asp Ala Thr Pro Thr Ala Gly Ala Arg Thr 485 490 495 Tyr Pro Lys Ile Ala Pro Pro Ala Gly Ala Pro Thr Pro Pro Ala Arg 500 505 510 Ser <210> 201 <211> 1684 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1654) <223> RXA04482 <400> 201 tccagcaatt gcaggctgaa gcccgccgag gcaccacagt actggcggtt tcgcatgatc 60 ctttgctgcg tgcggctgcc gatgaagtgg tggaggtcaa atg aac acc ctg gta 115 Met Asn Thr Leu Val 1 5 aaa ctt cgt ttc cgc gag cta att ccc gcc gtt gtt gca ggt agc gtc 163 Lys Leu Arg Phe Arg Glu Leu Ile Pro Ala Val Val Ala Gly Ser Val 10 15 20 acg atg atc gcc tcc atc acc ctg acg gtg gtg tcg gcc tgg ctg atc 211 Thr Met Ile Ala Ser Ile Thr Leu Thr Val Val Ser Ala Trp Leu Ile 25 30 35 acc aaa gct tgg gaa atg ccg cca gtg atg gat ctg acc gtg gcg gtc 259 Thr Lys Ala Trp Glu Met Pro Pro Val Met Asp Leu Thr Val Ala Val 40 45 50 acc gct gtg cga gcc ctg ggc att agc cgt gcg atg ttc cgt tat ata 307 Thr Ala Val Arg Ala Leu Gly Ile Ser Arg Ala Met Phe Arg Tyr Ile 55 60 65 gag aga atc gtt tca cat gac ttg gcg ttg aag gca gcc agc cga gcc 355 Glu Arg Ile Val Ser His Asp Leu Ala Leu Lys Ala Ala Ser Arg Ala 70 75 80 85 cgt tcg agt gca tat caa cgc ctg gct tcg tcg cca aac tct gcg ttg 403 Arg Ser Ser Ala Tyr Gln Arg Leu Ala Ser Ser Pro Asn Ser Ala Leu 90 95 100 acg atg cgc cgc ggc gaa ctg ctt agc cgc ctt ggt gtg gat atc gat 451 Thr Met Arg Arg Gly Glu Leu Leu Ser Arg Leu Gly Val Asp Ile Asp 105 110 115 tcg gtt gcc gat gtc atc gtc cgc gcc gtc att ccc gcc gga gtt gcc 499 Ser Val Ala Asp Val Ile Val Arg Ala Val Ile Pro Ala Gly Val Ala 120 125 130 ctg ctc acc gga gtt gtc gcg atc atc ttc acc gcg att ctc agc ccc 547 Leu Leu Thr Gly Val Val Ala Ile Ile Phe Thr Ala Ile Leu Ser Pro 135 140 145 gca acc gca ctt gtc ctg gcg att gga ttg att gct gct gca att atc 595 Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala Ala Ala Ile Ile 150 155 160 165 cct ccc ctg ctt gct gct cgc gga gtt aaa aca gcc gaa gcc cgg cgc 643 Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala Glu Ala Arg Arg 170 175 180 gct gaa tcc agc gaa gcc tac ttg agt tcc ttg gat cag gtg ctg tcc 691 Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp Gln Val Leu Ser 185 190 195 aac cag gcg gcg ctt cgt gtt cgt ggt gaa atg ccg gcc gct ctg tcc 739 Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro Ala Ala Leu Ser 200 205 210 aag gcg gat gtg gct gcg cgt tcc tat tct tct tca ctg gag gca ggc 787 Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser Leu Glu Ala Gly 215 220 225 gcg aaa gac act gcc att ggc gca gcg agt tcc ctg tgg att cac ggt 835 Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu Trp Ile His Gly 230 235 240 245 ttc act gtc att ggt gtg ctc atg gtt tcc gcg tca ctg tat gca gat 883 Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser Leu Tyr Ala Asp 250 255 260 gga agc cat tca ccg cag tgg ttt ggt gtg ttg gtg ctg ctt tca ctc 931 Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val Leu Leu Ser Leu 265 270 275 gca gct ttc gag gct gtc tct gtt ctc ccc gat gct gcg att gct cgt 979 Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala Ala Ile Ala Arg 280 285 290 acc cgc gcc gca gat gcc acc agg agg ctt gcg gaa atc tcg gcg ctg 1027 Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu Ile Ser Ala Leu 295 300 305 cca gaa tct gtc tct ctt gag ctt cgc acg gcc tct gac cag ccc gta 1075 Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser Asp Gln Pro Val 310 315 320 325 tta cgc gcc gag aat cta gtt tat gga tgg gac agc gac cta ggc acg 1123 Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser Asp Leu Gly Thr 330 335 340 agc aac ctg gat ctc acc ttt ggt tca cga cat gaa atc atc gca ccc 1171 Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu Ile Ile Ala Pro 345 350 355 tct gga act ggc aaa acg acc ctg ctg ctc aca ctt gcg ggg ctg ttg 1219 Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu Ala Gly Leu Leu 360 365 370 gaa cct cgt gga ggc caa gtg ctt atc gac ggc acc aat cct tcc gag 1267 Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr Asn Pro Ser Glu 375 380 385 ttg aaa aac gcc gtg ctg ttc agt cca gaa gat gcc cac att ttt gcc 1315 Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala His Ile Phe Ala 390 395 400 405 acc act gtc cga gat aac tta gca ctc gga gca ccg gaa gca acc gac 1363 Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro Glu Ala Thr Asp 410 415 420 gcg gaa atg aca tcg atc ctg gaa cat gtt ggt ttg tca gag tgg gtt 1411 Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu Ser Glu Trp Val 425 430 435 caa ggt tta ccc gat ggt ctt ggc act gtc ctt gat tca ggt gcc gat 1459 Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp Ser Gly Ala Asp 440 445 450 agt ctc tcg gga ggt cag cgc cgc cgc ctg ctc ctt gcc cgc gta cta 1507 Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu Ala Arg Val Leu 455 460 465 cta agt gat gca cca att ctg ctt ttg gat gaa ccc acc gag cac ctc 1555 Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro Thr Glu His Leu 470 475 480 485 gac act gca ggc tcc tct gaa atc ttg tct atg ctg gcc tcc gat gaa 1603 Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu Ala Ser Asp Glu 490 495 500 ctc cct ggt aaa aga gct agg aga acc gta gtg att gtg agg cat gtg 1651 Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile Val Arg His Val 505 510 515 agg taattttgcc ccgctgtctt ctgaccagaa 1684 Arg <210> 202 <211> 518 <212> PRT <213> Corynebacterium glutamicum <400> 202 Met Asn Thr Leu Val Lys Leu Arg Phe Arg Glu Leu Ile Pro Ala Val 1 5 10 15 Val Ala Gly Ser Val Thr Met Ile Ala Ser Ile Thr Leu Thr Val Val 20 25 30 Ser Ala Trp Leu Ile Thr Lys Ala Trp Glu Met Pro Pro Val Met Asp 35 40 45 Leu Thr Val Ala Val Thr Ala Val Arg Ala Leu Gly Ile Ser Arg Ala 50 55 60 Met Phe Arg Tyr Ile Glu Arg Ile Val Ser His Asp Leu Ala Leu Lys 65 70 75 80 Ala Ala Ser Arg Ala Arg Ser Ser Ala Tyr Gln Arg Leu Ala Ser Ser 85 90 95 Pro Asn Ser Ala Leu Thr Met Arg Arg Gly Glu Leu Leu Ser Arg Leu 100 105 110 Gly Val Asp Ile Asp Ser Val Ala Asp Val Ile Val Arg Ala Val Ile 115 120 125 Pro Ala Gly Val Ala Leu Leu Thr Gly Val Val Ala Ile Ile Phe Thr 130 135 140 Ala Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile 145 150 155 160 Ala Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr 165 170 175 Ala Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu 180 185 190 Asp Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met 195 200 205 Pro Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser 210 215 220 Ser Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser 225 230 235 240 Leu Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala 245 250 255 Ser Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu 260 265 270 Val Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp 275 280 285 Ala Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala 290 295 300 Glu Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala 305 310 315 320 Ser Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp 325 330 335 Ser Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His 340 345 350 Glu Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr 355 360 365 Leu Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly 370 375 380 Thr Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp 385 390 395 400 Ala His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala 405 410 415 Pro Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly 420 425 430 Leu Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu 435 440 445 Asp Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu 450 455 460 Leu Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu 465 470 475 480 Pro Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met 485 490 495 Leu Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val 500 505 510 Ile Val Arg His Val Arg 515 <210> 203 <211> 1456 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1426) <223> RXA04624 <400> 203 acattcatga tgatgtcctc agcaagtcca agcgccaagc catgctggaa acaattctcg 60 agctgatacc aagccagact taaatttcta ccttaaagtc ttg agc atg act gtt 115 Leu Ser Met Thr Val 1 5 cag gaa ttc gac cgc gcg acc aaa ccc aca cca aaa ccc cca att gtt 163 Gln Glu Phe Asp Arg Ala Thr Lys Pro Thr Pro Lys Pro Pro Ile Val 10 15 20 tct tgg gcg ttt tgg gat tgg ggt tcc gcc tct ttc aac gcg gtc ctc 211 Ser Trp Ala Phe Trp Asp Trp Gly Ser Ala Ser Phe Asn Ala Val Leu 25 30 35 gtg acc ttt att ttc tcg gtc tat ctc act gat tca gtc ggc gcc acc 259 Val Thr Phe Ile Phe Ser Val Tyr Leu Thr Asp Ser Val Gly Ala Thr 40 45 50 ctc ccc gag ggt tcc aac gcc aca tca ctg tat tcg atg gcg gtc gcc 307 Leu Pro Glu Gly Ser Asn Ala Thr Ser Leu Tyr Ser Met Ala Val Ala 55 60 65 atc gct ggc gtc att gtt gcg gtt gtt gcc cca gtc atg ggc agg cga 355 Ile Ala Gly Val Ile Val Ala Val Val Ala Pro Val Met Gly Arg Arg 70 75 80 85 tca gat atc aag ggc act cgc cgc agg tca ctg cgc atg tgg aca ctt 403 Ser Asp Ile Lys Gly Thr Arg Arg Arg Ser Leu Arg Met Trp Thr Leu 90 95 100 gtc acc gtg ttc ttg atg ttt tgt ctc ttt aca gta aag aac act gat 451 Val Thr Val Phe Leu Met Phe Cys Leu Phe Thr Val Lys Asn Thr Asp 105 110 115 ccc aca ttt ttc tgg ttt ggt gta gcc atc atg gcg atc gcc aac atc 499 Pro Thr Phe Phe Trp Phe Gly Val Ala Ile Met Ala Ile Ala Asn Ile 120 125 130 acc ttt gag ttc gct gaa gtt cag tac tat gcg cag ctc tcc caa atc 547 Thr Phe Glu Phe Ala Glu Val Gln Tyr Tyr Ala Gln Leu Ser Gln Ile 135 140 145 tcg acc cgc gaa aac gtg ggc cga gtt tct ggt ttc ggc tgg tcc atg 595 Ser Thr Arg Glu Asn Val Gly Arg Val Ser Gly Phe Gly Trp Ser Met 150 155 160 165 ggt tac ttc ggt ggc atc gtt cta ctg ctt gtt tgt tac cta ggt ttt 643 Gly Tyr Phe Gly Gly Ile Val Leu Leu Leu Val Cys Tyr Leu Gly Phe 170 175 180 gtt gcc ggt gat ggc gat acc cgc gga ttc cta aac ctg ccc atc gaa 691 Val Ala Gly Asp Gly Asp Thr Arg Gly Phe Leu Asn Leu Pro Ile Glu 185 190 195 gac ggc atg aat atc cgc ctc gtc gca gtg ctt gca gcc gtt tgg ttc 739 Asp Gly Met Asn Ile Arg Leu Val Ala Val Leu Ala Ala Val Trp Phe 200 205 210 ttg gtc tct gcg att ccg gca ctt ctt cga gtc cca gaa att gag gca 787 Leu Val Ser Ala Ile Pro Ala Leu Leu Arg Val Pro Glu Ile Glu Ala 215 220 225 cag gta gct gcc gaa gac cac ccc aaa ggc ctc ata gct gcc tac aag 835 Gln Val Ala Ala Glu Asp His Pro Lys Gly Leu Ile Ala Ala Tyr Lys 230 235 240 245 gat ctc ttt ggg cag atc gct gag ctg tgg aaa caa gac cgc aac tcc 883 Asp Leu Phe Gly Gln Ile Ala Glu Leu Trp Lys Gln Asp Arg Asn Ser 250 255 260 gtg tat ttc ctc atc gca gca gct gtt ttc cgt gac gga ctc gcc gga 931 Val Tyr Phe Leu Ile Ala Ala Ala Val Phe Arg Asp Gly Leu Ala Gly 265 270 275 gta ttt acc ttc ggt gcc atc ctt gcg gtc tct gtg tac gga cta tct 979 Val Phe Thr Phe Gly Ala Ile Leu Ala Val Ser Val Tyr Gly Leu Ser 280 285 290 gcc ggt gat gtc ctc ctc ttc ggt gtc gca gcc aac gtg gtc tct gcg 1027 Ala Gly Asp Val Leu Leu Phe Gly Val Ala Ala Asn Val Val Ser Ala 295 300 305 ttg gga gca ctc ctc gga gga ttc cta gac gat cgc gtc ggg cca aaa 1075 Leu Gly Ala Leu Leu Gly Gly Phe Leu Asp Asp Arg Val Gly Pro Lys 310 315 320 325 ccc atc atc ttg att tct ctt gcc atc atg atc gcc gat gct gca att 1123 Pro Ile Ile Leu Ile Ser Leu Ala Ile Met Ile Ala Asp Ala Ala Ile 330 335 340 ctc ttc ttc gtt gaa ggc ccc act aat ttc tgg atc ttc gga tta atc 1171 Leu Phe Phe Val Glu Gly Pro Thr Asn Phe Trp Ile Phe Gly Leu Ile 345 350 355 ctc tgt gcg ttt gtg gga cct gca cag tca gcg tcg aga agc tat tta 1219 Leu Cys Ala Phe Val Gly Pro Ala Gln Ser Ala Ser Arg Ser Tyr Leu 360 365 370 aca cgt ctt tcc cca gat ggc cag gaa ggc cag ctc ttc ggc ctt tat 1267 Thr Arg Leu Ser Pro Asp Gly Gln Glu Gly Gln Leu Phe Gly Leu Tyr 375 380 385 gcc act acc ggc cgt gcc gtg agt tgg atg gtg ccg tcg ctg ttt ggt 1315 Ala Thr Thr Gly Arg Ala Val Ser Trp Met Val Pro Ser Leu Phe Gly 390 395 400 405 gta ttt gtg ggg ctc acc ggc gat gac cgc act ggt att ttg gcc atc 1363 Val Phe Val Gly Leu Thr Gly Asp Asp Arg Thr Gly Ile Leu Ala Ile 410 415 420 gcg ctg att ctg cta ttc ggt att gtg ctg ctg agc atg gtg aag cca 1411 Ala Leu Ile Leu Leu Phe Gly Ile Val Leu Leu Ser Met Val Lys Pro 425 430 435 ccg cac aag gtg aag tagacaaagc gcccacaagg attacttgaa 1456 Pro His Lys Val Lys 440 <210> 204 <211> 442 <212> PRT <213> Corynebacterium glutamicum <400> 204 Leu Ser Met Thr Val Gln Glu Phe Asp Arg Ala Thr Lys Pro Thr Pro 1 5 10 15 Lys Pro Pro Ile Val Ser Trp Ala Phe Trp Asp Trp Gly Ser Ala Ser 20 25 30 Phe Asn Ala Val Leu Val Thr Phe Ile Phe Ser Val Tyr Leu Thr Asp 35 40 45 Ser Val Gly Ala Thr Leu Pro Glu Gly Ser Asn Ala Thr Ser Leu Tyr 50 55 60 Ser Met Ala Val Ala Ile Ala Gly Val Ile Val Ala Val Val Ala Pro 65 70 75 80 Val Met Gly Arg Arg Ser Asp Ile Lys Gly Thr Arg Arg Arg Ser Leu 85 90 95 Arg Met Trp Thr Leu Val Thr Val Phe Leu Met Phe Cys Leu Phe Thr 100 105 110 Val Lys Asn Thr Asp Pro Thr Phe Phe Trp Phe Gly Val Ala Ile Met 115 120 125 Ala Ile Ala Asn Ile Thr Phe Glu Phe Ala Glu Val Gln Tyr Tyr Ala 130 135 140 Gln Leu Ser Gln Ile Ser Thr Arg Glu Asn Val Gly Arg Val Ser Gly 145 150 155 160 Phe Gly Trp Ser Met Gly Tyr Phe Gly Gly Ile Val Leu Leu Leu Val 165 170 175 Cys Tyr Leu Gly Phe Val Ala Gly Asp Gly Asp Thr Arg Gly Phe Leu 180 185 190 Asn Leu Pro Ile Glu Asp Gly Met Asn Ile Arg Leu Val Ala Val Leu 195 200 205 Ala Ala Val Trp Phe Leu Val Ser Ala Ile Pro Ala Leu Leu Arg Val 210 215 220 Pro Glu Ile Glu Ala Gln Val Ala Ala Glu Asp His Pro Lys Gly Leu 225 230 235 240 Ile Ala Ala Tyr Lys Asp Leu Phe Gly Gln Ile Ala Glu Leu Trp Lys 245 250 255 Gln Asp Arg Asn Ser Val Tyr Phe Leu Ile Ala Ala Ala Val Phe Arg 260 265 270 Asp Gly Leu Ala Gly Val Phe Thr Phe Gly Ala Ile Leu Ala Val Ser 275 280 285 Val Tyr Gly Leu Ser Ala Gly Asp Val Leu Leu Phe Gly Val Ala Ala 290 295 300 Asn Val Val Ser Ala Leu Gly Ala Leu Leu Gly Gly Phe Leu Asp Asp 305 310 315 320 Arg Val Gly Pro Lys Pro Ile Ile Leu Ile Ser Leu Ala Ile Met Ile 325 330 335 Ala Asp Ala Ala Ile Leu Phe Phe Val Glu Gly Pro Thr Asn Phe Trp 340 345 350 Ile Phe Gly Leu Ile Leu Cys Ala Phe Val Gly Pro Ala Gln Ser Ala 355 360 365 Ser Arg Ser Tyr Leu Thr Arg Leu Ser Pro Asp Gly Gln Glu Gly Gln 370 375 380 Leu Phe Gly Leu Tyr Ala Thr Thr Gly Arg Ala Val Ser Trp Met Val 385 390 395 400 Pro Ser Leu Phe Gly Val Phe Val Gly Leu Thr Gly Asp Asp Arg Thr 405 410 415 Gly Ile Leu Ala Ile Ala Leu Ile Leu Leu Phe Gly Ile Val Leu Leu 420 425 430 Ser Met Val Lys Pro Pro His Lys Val Lys 435 440 <210> 205 <211> 1146 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1146) <223> RXA07009 <400> 205 atg gga gtc ggt ttc gcg gga atc ccg ctg cgc gaa ttg gga ttg gtt 48 Met Gly Val Gly Phe Ala Gly Ile Pro Leu Arg Glu Leu Gly Leu Val 1 5 10 15 atc ctc gtt gca gcg gcc atc acg tat ctc agc acg ggc atc atc cgc 96 Ile Leu Val Ala Ala Ala Ile Thr Tyr Leu Ser Thr Gly Ile Ile Arg 20 25 30 acc gtc atg gtg aaa agt ggt cgc ctc aat gag att cgt gaa cga gac 144 Thr Val Met Val Lys Ser Gly Arg Leu Asn Glu Ile Arg Glu Arg Asp 35 40 45 gtc cat gtc atc ccc aaa cca cgg ctt ggt ggc gtg gcg atg ttc agt 192 Val His Val Ile Pro Lys Pro Arg Leu Gly Gly Val Ala Met Phe Ser 50 55 60 gga ttt ctc ggc gca gta ttc ctt gcg gac cag ctt ccc gcc ttg act 240 Gly Phe Leu Gly Ala Val Phe Leu Ala Asp Gln Leu Pro Ala Leu Thr 65 70 75 80 cgc ggg ttc atg ccc atc acc ccg gag atg aat gcc gtc att tgg gca 288 Arg Gly Phe Met Pro Ile Thr Pro Glu Met Asn Ala Val Ile Trp Ala 85 90 95 ggc ttt gtc atc gtg gtg gtg ggc gca ctg gat gac ctt ttt gat ctt 336 Gly Phe Val Ile Val Val Val Gly Ala Leu Asp Asp Leu Phe Asp Leu 100 105 110 gat gcc atc act aaa ttg gtg ggt caa gta att ggt gcg gtg act atg 384 Asp Ala Ile Thr Lys Leu Val Gly Gln Val Ile Gly Ala Val Thr Met 115 120 125 agt ttg ctt ggt ctc acg tgg tcc atc ctc tat gtt ccc ttc ggt ggg 432 Ser Leu Leu Gly Leu Thr Trp Ser Ile Leu Tyr Val Pro Phe Gly Gly 130 135 140 ggc acc aca ttg ctt ctc gac caa gtc cag tca aca atc ttg aca tcc 480 Gly Thr Thr Leu Leu Leu Asp Gln Val Gln Ser Thr Ile Leu Thr Ser 145 150 155 160 ctg ttc acc gtg gcg ttg att aat gct ctg aac ttc gtt gac ggt ctt 528 Leu Phe Thr Val Ala Leu Ile Asn Ala Leu Asn Phe Val Asp Gly Leu 165 170 175 gac ggc ttg agt gcc ggc gta gga atg atc gcg ggt gca gcc atc ctg 576 Asp Gly Leu Ser Ala Gly Val Gly Met Ile Ala Gly Ala Ala Ile Leu 180 185 190 ctg ttc tcc ctg acg att ctc ttc gac caa aac ggc gcc gta tcg gcc 624 Leu Phe Ser Leu Thr Ile Leu Phe Asp Gln Asn Gly Ala Val Ser Ala 195 200 205 tat ccg ccg gcc atc atc gca gcg gct ctc gta gga att tgc gcg gga 672 Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile Cys Ala Gly 210 215 220 gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg ggc gat tcc 720 Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met Gly Asp Ser 225 230 235 240 ggc tcc atg ctc atc ggc ctg ctg ttg gct gca gca tcg acc tca gcg 768 Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser Thr Ser Ala 245 250 255 tca gga aaa atc aac atg agc ctg tat ggc gca gct gat ttt atc gca 816 Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp Phe Ile Ala 260 265 270 ttg atc tca ccc atc atc gtt gtt ctc gcc gcc gtg gcc atc cca ctg 864 Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala Ile Pro Leu 275 280 285 ctc gac ctc gtg atg gca gtg gtt agg cgc gtg ggc agg gga gca tca 912 Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg Gly Ala Ser 290 295 300 ccc ttt tcc ccg gac aaa atg cat ctg cac cac cga ctg ctg tcc atc 960 Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu Leu Ser Ile 305 310 315 320 gga cac acc cat agg cgc gtg gtc cta gtg ctc tac acc tgg gcg agc 1008 Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr Trp Ala Ser 325 330 335 gcc gtg gca ttc ggc gca gtg agc ttc tcc gtc gtt ccg cca ctg ttt 1056 Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro Pro Leu Phe 340 345 350 gcc acc gga tcg agc atc tgt ggc atc ctc atc gcc gtc gct gtc aca 1104 Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val Ala Val Thr 355 360 365 gcc gtg cca gtg atg aaa agc cgg cga gcc gcc aaa ctt gat 1146 Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu Asp 370 375 380 <210> 206 <211> 382 <212> PRT <213> Corynebacterium glutamicum <400> 206 Met Gly Val Gly Phe Ala Gly Ile Pro Leu Arg Glu Leu Gly Leu Val 1 5 10 15 Ile Leu Val Ala Ala Ala Ile Thr Tyr Leu Ser Thr Gly Ile Ile Arg 20 25 30 Thr Val Met Val Lys Ser Gly Arg Leu Asn Glu Ile Arg Glu Arg Asp 35 40 45 Val His Val Ile Pro Lys Pro Arg Leu Gly Gly Val Ala Met Phe Ser 50 55 60 Gly Phe Leu Gly Ala Val Phe Leu Ala Asp Gln Leu Pro Ala Leu Thr 65 70 75 80 Arg Gly Phe Met Pro Ile Thr Pro Glu Met Asn Ala Val Ile Trp Ala 85 90 95 Gly Phe Val Ile Val Val Val Gly Ala Leu Asp Asp Leu Phe Asp Leu 100 105 110 Asp Ala Ile Thr Lys Leu Val Gly Gln Val Ile Gly Ala Val Thr Met 115 120 125 Ser Leu Leu Gly Leu Thr Trp Ser Ile Leu Tyr Val Pro Phe Gly Gly 130 135 140 Gly Thr Thr Leu Leu Leu Asp Gln Val Gln Ser Thr Ile Leu Thr Ser 145 150 155 160 Leu Phe Thr Val Ala Leu Ile Asn Ala Leu Asn Phe Val Asp Gly Leu 165 170 175 Asp Gly Leu Ser Ala Gly Val Gly Met Ile Ala Gly Ala Ala Ile Leu 180 185 190 Leu Phe Ser Leu Thr Ile Leu Phe Asp Gln Asn Gly Ala Val Ser Ala 195 200 205 Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile Cys Ala Gly 210 215 220 Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met Gly Asp Ser 225 230 235 240 Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser Thr Ser Ala 245 250 255 Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp Phe Ile Ala 260 265 270 Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala Ile Pro Leu 275 280 285 Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg Gly Ala Ser 290 295 300 Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu Leu Ser Ile 305 310 315 320 Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr Trp Ala Ser 325 330 335 Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro Pro Leu Phe 340 345 350 Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val Ala Val Thr 355 360 365 Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu Asp 370 375 380 <210> 207 <211> 846 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(846) <223> RXA07010 <400> 207 atg agc acc tta acc tct cac cgc aca gta ccg gcc ccc agc tct ccc 48 Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro 1 5 10 15 ccg gcg cgc ccc aac aaa ctg gcg cgc aat atc gtt gca att gtc gct 96 Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala 20 25 30 gcg ctg att gtc ctt ata gct acc ggc acg ctc aag atc gag tgg aat 144 Ala Leu Ile Val Leu Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn 35 40 45 gag ctt ccg cag atg ccc gcg cag gtg tgg cat tac tta gag ctg atg 192 Glu Leu Pro Gln Met Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met 50 55 60 ttt agc gat ccc gat tgg tcg aag ttt ggc cgc gcc gtc cag gaa atg 240 Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met 65 70 75 80 tgg cgt tcc atc gcc atg gcg tgg ttg ggt gcc att tta tgc gtg gtg 288 Trp Arg Ser Ile Ala Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val 85 90 95 gtc tct gtc cct ctg gga atg ttg gct gcc cgc ggg gtg gga cct tat 336 Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr 100 105 110 tgg ctg cgt acc gtt tta cgg ttc gtg ttc gcg gtg att cgt gcg ttc 384 Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe 115 120 125 ccc gaa gtg gtt atc gca att att ttg cta act gtc acc ggc cta act 432 Pro Glu Val Val Ile Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr 130 135 140 cct ttt act ggt gcg ctc gca ttg ggt atc tcc ggt att gga caa cag 480 Pro Phe Thr Gly Ala Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln 145 150 155 160 gca aag tgg acc tat gaa gcc att gag tcc act ccc acc ggc ccg tca 528 Ala Lys Trp Thr Tyr Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser 165 170 175 gag gca gtg cgt gca gcg ggt gga act acg ccg gag gtt ctg cgg tgg 576 Glu Ala Val Arg Ala Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp 180 185 190 gcg ttg tgg cca cag gtt gcg cca tcc att gca tct ttt gcc ctg tac 624 Ala Leu Trp Pro Gln Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr 195 200 205 cgc ttt gag atc aac atc cgt acc tct gcg gta ttg ggc atc gtt ggt 672 Arg Phe Glu Ile Asn Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly 210 215 220 gca ggt ggt atc ggt agt atg ctt gcc aat tac acc aac tac agg cag 720 Ala Gly Gly Ile Gly Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln 225 230 235 240 tgg gac acc gtg ggc atg ctg ctc atc gtc gtg gtt gtc gca acg atg 768 Trp Asp Thr Val Gly Met Leu Leu Ile Val Val Val Val Ala Thr Met 245 250 255 atc gtc gat ctc atc tcc ggc acc atc cgc cgc cgc atc atg aag ggg 816 Ile Val Asp Leu Ile Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly 260 265 270 gct agt gac cgt gtc gtg gca cca agc aac 846 Ala Ser Asp Arg Val Val Ala Pro Ser Asn 275 280 <210> 208 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 208 Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro 1 5 10 15 Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala 20 25 30 Ala Leu Ile Val Leu Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn 35 40 45 Glu Leu Pro Gln Met Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met 50 55 60 Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met 65 70 75 80 Trp Arg Ser Ile Ala Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val 85 90 95 Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr 100 105 110 Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe 115 120 125 Pro Glu Val Val Ile Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr 130 135 140 Pro Phe Thr Gly Ala Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln 145 150 155 160 Ala Lys Trp Thr Tyr Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser 165 170 175 Glu Ala Val Arg Ala Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp 180 185 190 Ala Leu Trp Pro Gln Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr 195 200 205 Arg Phe Glu Ile Asn Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly 210 215 220 Ala Gly Gly Ile Gly Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln 225 230 235 240 Trp Asp Thr Val Gly Met Leu Leu Ile Val Val Val Val Ala Thr Met 245 250 255 Ile Val Asp Leu Ile Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly 260 265 270 Ala Ser Asp Arg Val Val Ala Pro Ser Asn 275 280 <210> 209 <211> 1155 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1155) <223> RXA07012 <400> 209 atg act aat gaa cga att ttt cta tca tcg cca gat gta aca cag tta 48 Met Thr Asn Glu Arg Ile Phe Leu Ser Ser Pro Asp Val Thr Gln Leu 1 5 10 15 gag gaa gac gca ttg gta cgc gca atc cga tca gga tgg att gca ccg 96 Glu Glu Asp Ala Leu Val Arg Ala Ile Arg Ser Gly Trp Ile Ala Pro 20 25 30 ctt ggt cca gaa gtt gat gcg ttt gag caa gaa ctt gct gag tat tgt 144 Leu Gly Pro Glu Val Asp Ala Phe Glu Gln Glu Leu Ala Glu Tyr Cys 35 40 45 ggc cgc aaa tat gtt gtt gca ctt tca tcg ggt act gca gcc ctc cac 192 Gly Arg Lys Tyr Val Val Ala Leu Ser Ser Gly Thr Ala Ala Leu His 50 55 60 tta ggt cta tta gca cta ggc gtt gga gaa gga gac ttg gtt ctt aca 240 Leu Gly Leu Leu Ala Leu Gly Val Gly Glu Gly Asp Leu Val Leu Thr 65 70 75 80 tca tca atg act ttt gca gcg acc acc aac gca att gtt tat acg ggt 288 Ser Ser Met Thr Phe Ala Ala Thr Thr Asn Ala Ile Val Tyr Thr Gly 85 90 95 gct gag cca att ttc gtg gac tgc gat gaa tct gga aat atg gat cca 336 Ala Glu Pro Ile Phe Val Asp Cys Asp Glu Ser Gly Asn Met Asp Pro 100 105 110 gat ctt tta gaa aaa gcc ttt gct gag cta aag agt gaa gga aag gaa 384 Asp Leu Leu Glu Lys Ala Phe Ala Glu Leu Lys Ser Glu Gly Lys Glu 115 120 125 gta aag gct gta gta cct gtc gat cta ctt ggc aaa gtt gtt cag cac 432 Val Lys Ala Val Val Pro Val Asp Leu Leu Gly Lys Val Val Gln His 130 135 140 gag aag att aaa aag att gct gat gaa tac ggg gca gta gtg ctt tct 480 Glu Lys Ile Lys Lys Ile Ala Asp Glu Tyr Gly Ala Val Val Leu Ser 145 150 155 160 gat gcc gct gaa tcc ttg ggc gcc att cgc aat gga aag tct gct gca 528 Asp Ala Ala Glu Ser Leu Gly Ala Ile Arg Asn Gly Lys Ser Ala Ala 165 170 175 gca tat gga gtg gcg gca gcg gtt tcc ttc aac gga aac aaa att atg 576 Ala Tyr Gly Val Ala Ala Ala Val Ser Phe Asn Gly Asn Lys Ile Met 180 185 190 act acc agc ggt ggt gga gct ttg tta act gat gac aag gat att gca 624 Thr Thr Ser Gly Gly Gly Ala Leu Leu Thr Asp Asp Lys Asp Ile Ala 195 200 205 gac aac gtc cgc tat ctt gcg aca caa gct cgc caa cct gta gtt cat 672 Asp Asn Val Arg Tyr Leu Ala Thr Gln Ala Arg Gln Pro Val Val His 210 215 220 tac gaa cac acc gat gtt ggg tat aac tat cgc ctt tca aat atc ctc 720 Tyr Glu His Thr Asp Val Gly Tyr Asn Tyr Arg Leu Ser Asn Ile Leu 225 230 235 240 gct gca ctg gga cga gct caa ctt tcc cga ctc gac aag atg att gag 768 Ala Ala Leu Gly Arg Ala Gln Leu Ser Arg Leu Asp Lys Met Ile Glu 245 250 255 cgt cga cgt caa cac cgt gcg ttc tat cga gaa ttg ttt gca ggt gtt 816 Arg Arg Arg Gln His Arg Ala Phe Tyr Arg Glu Leu Phe Ala Gly Val 260 265 270 tct gga gta gag atc ttt ggc gag cca tca ggg gtc gat ggt ggc gac 864 Ser Gly Val Glu Ile Phe Gly Glu Pro Ser Gly Val Asp Gly Gly Asp 275 280 285 act att gat aat ttc tgg ctc act tct att ctt att gat aaa gaa gtt 912 Thr Ile Asp Asn Phe Trp Leu Thr Ser Ile Leu Ile Asp Lys Glu Val 290 295 300 gcg gga ttt agc tct gaa gat ctt cga tca gtt cta aat cag gcg aat 960 Ala Gly Phe Ser Ser Glu Asp Leu Arg Ser Val Leu Asn Gln Ala Asn 305 310 315 320 att gag tct cgt ccc ttg tgg aaa cca atg cat ctc cag cca gta ttt 1008 Ile Glu Ser Arg Pro Leu Trp Lys Pro Met His Leu Gln Pro Val Phe 325 330 335 aag aag tat cgt agc ttc acc aat gaa gaa gga cag agg cta ttt gat 1056 Lys Lys Tyr Arg Ser Phe Thr Asn Glu Glu Gly Gln Arg Leu Phe Asp 340 345 350 tca ggg ctt tct ctc cca agc ggt tca gta ctt gat aat gcg tca atg 1104 Ser Gly Leu Ser Leu Pro Ser Gly Ser Val Leu Asp Asn Ala Ser Met 355 360 365 aat cgt gtt gag act aca att ggc cag ttt ttg gag agt cag cat gcg 1152 Asn Arg Val Glu Thr Thr Ile Gly Gln Phe Leu Glu Ser Gln His Ala 370 375 380 atc 1155 Ile 385 <210> 210 <211> 385 <212> PRT <213> Corynebacterium glutamicum <400> 210 Met Thr Asn Glu Arg Ile Phe Leu Ser Ser Pro Asp Val Thr Gln Leu 1 5 10 15 Glu Glu Asp Ala Leu Val Arg Ala Ile Arg Ser Gly Trp Ile Ala Pro 20 25 30 Leu Gly Pro Glu Val Asp Ala Phe Glu Gln Glu Leu Ala Glu Tyr Cys 35 40 45 Gly Arg Lys Tyr Val Val Ala Leu Ser Ser Gly Thr Ala Ala Leu His 50 55 60 Leu Gly Leu Leu Ala Leu Gly Val Gly Glu Gly Asp Leu Val Leu Thr 65 70 75 80 Ser Ser Met Thr Phe Ala Ala Thr Thr Asn Ala Ile Val Tyr Thr Gly 85 90 95 Ala Glu Pro Ile Phe Val Asp Cys Asp Glu Ser Gly Asn Met Asp Pro 100 105 110 Asp Leu Leu Glu Lys Ala Phe Ala Glu Leu Lys Ser Glu Gly Lys Glu 115 120 125 Val Lys Ala Val Val Pro Val Asp Leu Leu Gly Lys Val Val Gln His 130 135 140 Glu Lys Ile Lys Lys Ile Ala Asp Glu Tyr Gly Ala Val Val Leu Ser 145 150 155 160 Asp Ala Ala Glu Ser Leu Gly Ala Ile Arg Asn Gly Lys Ser Ala Ala 165 170 175 Ala Tyr Gly Val Ala Ala Ala Val Ser Phe Asn Gly Asn Lys Ile Met 180 185 190 Thr Thr Ser Gly Gly Gly Ala Leu Leu Thr Asp Asp Lys Asp Ile Ala 195 200 205 Asp Asn Val Arg Tyr Leu Ala Thr Gln Ala Arg Gln Pro Val Val His 210 215 220 Tyr Glu His Thr Asp Val Gly Tyr Asn Tyr Arg Leu Ser Asn Ile Leu 225 230 235 240 Ala Ala Leu Gly Arg Ala Gln Leu Ser Arg Leu Asp Lys Met Ile Glu 245 250 255 Arg Arg Arg Gln His Arg Ala Phe Tyr Arg Glu Leu Phe Ala Gly Val 260 265 270 Ser Gly Val Glu Ile Phe Gly Glu Pro Ser Gly Val Asp Gly Gly Asp 275 280 285 Thr Ile Asp Asn Phe Trp Leu Thr Ser Ile Leu Ile Asp Lys Glu Val 290 295 300 Ala Gly Phe Ser Ser Glu Asp Leu Arg Ser Val Leu Asn Gln Ala Asn 305 310 315 320 Ile Glu Ser Arg Pro Leu Trp Lys Pro Met His Leu Gln Pro Val Phe 325 330 335 Lys Lys Tyr Arg Ser Phe Thr Asn Glu Glu Gly Gln Arg Leu Phe Asp 340 345 350 Ser Gly Leu Ser Leu Pro Ser Gly Ser Val Leu Asp Asn Ala Ser Met 355 360 365 Asn Arg Val Glu Thr Thr Ile Gly Gln Phe Leu Glu Ser Gln His Ala 370 375 380 Ile 385 <210> 211 <211> 1083 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1083) <223> RXA07013 <400> 211 atg gct gtc atg gca tat caa cca gca gac aat cgc tat gac gac atg 48 Met Ala Val Met Ala Tyr Gln Pro Ala Asp Asn Arg Tyr Asp Asp Met 1 5 10 15 atc tac cgc agg gtg gga aat tct ggg ctg aag ctt ccg gca att tcg 96 Ile Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile Ser 20 25 30 ctt ggg ctg tgg cac aac ttc ggt gat gac aag ccg ctt tca acg cag 144 Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln 35 40 45 cgc agc att att cac cgc gcg ttt gat agg gga gtc act cac ttc gat 192 Arg Ser Ile Ile His Arg Ala Phe Asp Arg Gly Val Thr His Phe Asp 50 55 60 ttg gct aat aac tat gga cct cca gca ggt tcc gca gag acc aac ttt 240 Leu Ala Asn Asn Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn Phe 65 70 75 80 ggc agg att ttg cgt gag gat ctc aaa agc cac cgc gat gag ttg atc 288 Gly Arg Ile Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu Ile 85 90 95 att tct tcc aag gcg ggt tgg gat atg tgg cct gga cct tat ggt ttt 336 Ile Ser Ser Lys Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe 100 105 110 ggt ggt tcc cga aag tat cta gtg agt tcc ctt gat cag tcc ctg act 384 Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr 115 120 125 cgc ctc ggc ttg gat tac gtg gat att ttc tat cat cac cgc ccg gat 432 Arg Leu Gly Leu Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro Asp 130 135 140 cca gat act cct ttg gaa gaa acc atg tac gca ttg cgt gac att gtt 480 Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile Val 145 150 155 160 gcg tct gga aag gct ctt tac gtg ggt att tct tcc tac ggt cca gag 528 Ala Ser Gly Lys Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro Glu 165 170 175 ctc aca gcg gag gcg gct gag ttc atg gcg gag gag ggc tgc ccg ctt 576 Leu Thr Ala Glu Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu 180 185 190 ctg att cat cag cca agc tat tcc atc att aat cgt tgg gtg gag gaa 624 Leu Ile His Gln Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu Glu 195 200 205 ccg ggc gat gac ggt gag aac ttg ttg cag tca gct gcc aac aat ggt 672 Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn Gly 210 215 220 ctt ggc gtc att gct ttc tca cca ctt gcg cag ggc ctg ctc acg gac 720 Leu Gly Val Ile Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr Asp 225 230 235 240 aaa tat ctc gat gga att cca gag ggt tcc cgc gcc agc cag ggt aag 768 Lys Tyr Leu Asp Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys 245 250 255 tcc ctg tct gag ggc atg ttg aac gtg aac aat att gat atg gtc cgc 816 Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn Ile Asp Met Val Arg 260 265 270 aag ctc aat gac atc gcc cag gaa cgc ggg cag tca ctt gcg cag atg 864 Lys Leu Asn Asp Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln Met 275 280 285 gcg ctt gca tgg gtg ctg cgc gag caa gga gag tac ggc gcg gat acc 912 Ala Leu Ala Trp Val Leu Arg Glu Gln Gly Glu Tyr Gly Ala Asp Thr 290 295 300 gtg acc agt gca ttg att ggt gct tcg tca gtt gag cag ctg gac aac 960 Val Thr Ser Ala Leu Ile Gly Ala Ser Ser Val Glu Gln Leu Asp Asn 305 310 315 320 agc ctt gat tca ctc aac aac ttg gag ttt tct gac gcc gag ttg gag 1008 Ser Leu Asp Ser Leu Asn Asn Leu Glu Phe Ser Asp Ala Glu Leu Glu 325 330 335 gcg atc gat gag att tcc cac gac gcc ggc atc aac att tgg gcg aag 1056 Ala Ile Asp Glu Ile Ser His Asp Ala Gly Ile Asn Ile Trp Ala Lys 340 345 350 gcc acc gat tcc aaa acc cgc gaa aac 1083 Ala Thr Asp Ser Lys Thr Arg Glu Asn 355 360 <210> 212 <211> 361 <212> PRT <213> Corynebacterium glutamicum <400> 212 Met Ala Val Met Ala Tyr Gln Pro Ala Asp Asn Arg Tyr Asp Asp Met 1 5 10 15 Ile Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile Ser 20 25 30 Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln 35 40 45 Arg Ser Ile Ile His Arg Ala Phe Asp Arg Gly Val Thr His Phe Asp 50 55 60 Leu Ala Asn Asn Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn Phe 65 70 75 80 Gly Arg Ile Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu Ile 85 90 95 Ile Ser Ser Lys Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe 100 105 110 Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr 115 120 125 Arg Leu Gly Leu Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro Asp 130 135 140 Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile Val 145 150 155 160 Ala Ser Gly Lys Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro Glu 165 170 175 Leu Thr Ala Glu Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu 180 185 190 Leu Ile His Gln Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu Glu 195 200 205 Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn Gly 210 215 220 Leu Gly Val Ile Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr Asp 225 230 235 240 Lys Tyr Leu Asp Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys 245 250 255 Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn Ile Asp Met Val Arg 260 265 270 Lys Leu Asn Asp Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln Met 275 280 285 Ala Leu Ala Trp Val Leu Arg Glu Gln Gly Glu Tyr Gly Ala Asp Thr 290 295 300 Val Thr Ser Ala Leu Ile Gly Ala Ser Ser Val Glu Gln Leu Asp Asn 305 310 315 320 Ser Leu Asp Ser Leu Asn Asn Leu Glu Phe Ser Asp Ala Glu Leu Glu 325 330 335 Ala Ile Asp Glu Ile Ser His Asp Ala Gly Ile Asn Ile Trp Ala Lys 340 345 350 Ala Thr Asp Ser Lys Thr Arg Glu Asn 355 360 <210> 213 <211> 1767 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1767) <223> RXA07022 <400> 213 atg agt ggg gag acg tcg aaa agc atg cgc ttt ccg ttg gcc agc ctg 48 Met Ser Gly Glu Thr Ser Lys Ser Met Arg Phe Pro Leu Ala Ser Leu 1 5 10 15 ccg caa gtg cgg cgc gag gtg gcc cgg cag gtg ggt cgt att ccg cgg 96 Pro Gln Val Arg Arg Glu Val Ala Arg Gln Val Gly Arg Ile Pro Arg 20 25 30 gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc gct 144 Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly Ala 35 40 45 tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat ctg 192 Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp Leu 50 55 60 gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg att 240 Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val Ile 65 70 75 80 ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg ttc 288 Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly Phe 85 90 95 tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg gaa 336 Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg Glu 100 105 110 gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa gat 384 Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu Asp 115 120 125 gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc gag 432 Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser Glu 130 135 140 cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca ctg 480 Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser Leu 145 150 155 160 ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg caa 528 Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp Gln 165 170 175 ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg tcc 576 Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala Ser 180 185 190 aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc gcg 624 Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg Ala 195 200 205 gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg cgt 672 Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly Arg 210 215 220 gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag att 720 Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln Ile 225 230 235 240 gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc acc 768 Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg Thr 245 250 255 acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc atg 816 Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu Met 260 265 270 ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat gat gcg 864 Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asp Ala 275 280 285 ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt ctg 912 Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg Leu 290 295 300 cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa tcc 960 Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln Ser 305 310 315 320 ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg ccg 1008 Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro Pro 325 330 335 att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg gaa 1056 Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val Glu 340 345 350 ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa gac 1104 Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys Asp 355 360 365 atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc gca 1152 Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly Ala 370 375 380 tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg cgg 1200 Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu Arg 385 390 395 400 gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct cac 1248 Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser His 405 410 415 ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag gag 1296 Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln Glu 420 425 430 gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct aaa 1344 Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala Lys 435 440 445 cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt aat 1392 Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val Asn 450 455 460 gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc gtt 1440 Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val Val 465 470 475 480 ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg gcg 1488 Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu Ala 485 490 495 ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat gaa 1536 Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp Glu 500 505 510 gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag gct 1584 Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu Ala 515 520 525 gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac cgg 1632 Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His Arg 530 535 540 ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag ggg 1680 Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys Gly 545 550 555 560 gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg ggt 1728 Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly Gly 565 570 575 att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1767 Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 580 585 <210> 214 <211> 589 <212> PRT <213> Corynebacterium glutamicum <400> 214 Met Ser Gly Glu Thr Ser Lys Ser Met Arg Phe Pro Leu Ala Ser Leu 1 5 10 15 Pro Gln Val Arg Arg Glu Val Ala Arg Gln Val Gly Arg Ile Pro Arg 20 25 30 Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly Ala 35 40 45 Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp Leu 50 55 60 Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val Ile 65 70 75 80 Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly Phe 85 90 95 Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg Glu 100 105 110 Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu Asp 115 120 125 Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser Glu 130 135 140 Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser Leu 145 150 155 160 Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp Gln 165 170 175 Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala Ser 180 185 190 Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg Ala 195 200 205 Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly Arg 210 215 220 Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln Ile 225 230 235 240 Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg Thr 245 250 255 Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu Met 260 265 270 Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asp Ala 275 280 285 Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg Leu 290 295 300 Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln Ser 305 310 315 320 Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro Pro 325 330 335 Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val Glu 340 345 350 Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys Asp 355 360 365 Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly Ala 370 375 380 Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu Arg 385 390 395 400 Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser His 405 410 415 Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln Glu 420 425 430 Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala Lys 435 440 445 Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val Asn 450 455 460 Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val Val 465 470 475 480 Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu Ala 485 490 495 Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp Glu 500 505 510 Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu Ala 515 520 525 Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His Arg 530 535 540 Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys Gly 545 550 555 560 Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly Gly 565 570 575 Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 580 585

Claims (8)

  1. 표 1의 컬럼 2에 각각 나타낸 아미노산 서열을 갖는 폴리펩티드를 코딩하며, 표 1의 컬럼 4에 나타낸 아미노산 위치에서 그와 동일 열에 있는 표 1의 컬럼 5에 나타낸 특정 아미노산이 아닌 단백질원성 아미노산을 코딩하는 단리된 핵산 분자.
  2. 제1항에 있어서, 표 1의 컬럼 4에 나타낸 아미노산 위치에서 그와 동일 열에 있는 컬럼 6에 나타낸 아미노산을 코딩하는 단리된 핵산 분자.
  3. 제1항에 따른 하나 이상의 핵산 서열을 포함하는 벡터.
  4. 제3항에 따른 하나 이상의 벡터로 형질감염된 숙주 세포.
  5. 제4항에 있어서, 상기 핵산 분자의 발현에 의해 상기 세포로부터의 정밀 화학물질 (fine chemical) 생산이 조정되는 숙주 세포.
  6. 제3항에 따른 하나 이상의 벡터로 형질감염된 세포를 배양하여 정밀 화학물질이 생산되도록 하는 단계를 포함하는, 정밀 화학물질의 제조 방법.
  7. 제6항에 있어서, 정밀 화학물질이 아미노산인 방법.
  8. 제7항에 있어서, 상기 아미노산이 리신인 방법.
KR10-2004-7006761A 2001-11-05 2002-10-31 막 합성 및 막 수송 단백질을 코딩하는 유전자 KR20040058265A (ko)

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DE10154179A DE10154179A1 (de) 2001-11-05 2001-11-05 Gene die für membeansynthese-und Membrantransport-Proteine codieren
DE10154179.1 2001-11-05
PCT/EP2002/012136 WO2003040292A2 (de) 2001-11-05 2002-10-31 Gene die für membransynthese- und membrantransport-proteine codieren

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DE10359661A1 (de) 2003-12-18 2005-07-28 Basf Ag Genvarianten die für Proteine aus dem Stoffwechselweg von Feinchemikalien codieren
EP2330184B1 (en) 2008-09-01 2020-11-25 Shinshu University Process for producing a useful substance in coryneform bacteria
WO2019228937A1 (en) * 2018-05-28 2019-12-05 Universitaet Des Saarlandes Means and methods for the production of glutarate

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WO2003040292A3 (de) 2004-06-03

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