KR20040008146A - 프레가발린 락토스 접합체 - Google Patents

프레가발린 락토스 접합체 Download PDF

Info

Publication number
KR20040008146A
KR20040008146A KR10-2003-7012714A KR20037012714A KR20040008146A KR 20040008146 A KR20040008146 A KR 20040008146A KR 20037012714 A KR20037012714 A KR 20037012714A KR 20040008146 A KR20040008146 A KR 20040008146A
Authority
KR
South Korea
Prior art keywords
tetrahydro
pyran
isobutyl
pyrrolidin
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2003-7012714A
Other languages
English (en)
Korean (ko)
Inventor
티모시 로버트 허레이
마이클 제임스 로브달
브라이언 토비아스
Original Assignee
워너-램버트 캄파니 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 워너-램버트 캄파니 엘엘씨 filed Critical 워너-램버트 캄파니 엘엘씨
Publication of KR20040008146A publication Critical patent/KR20040008146A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-2003-7012714A 2001-03-30 2002-02-25 프레가발린 락토스 접합체 Ceased KR20040008146A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28017601P 2001-03-30 2001-03-30
US60/280.176 2001-03-30
PCT/IB2002/000647 WO2002078747A2 (en) 2001-03-30 2002-02-25 Pregabalin lactose conjugates

Publications (1)

Publication Number Publication Date
KR20040008146A true KR20040008146A (ko) 2004-01-28

Family

ID=23072002

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7012714A Ceased KR20040008146A (ko) 2001-03-30 2002-02-25 프레가발린 락토스 접합체

Country Status (32)

Country Link
US (1) US7022678B2 (OSRAM)
EP (1) EP1377318A2 (OSRAM)
JP (1) JP2004524357A (OSRAM)
KR (1) KR20040008146A (OSRAM)
CN (1) CN1511043A (OSRAM)
AP (1) AP2003002873A0 (OSRAM)
AR (1) AR033024A1 (OSRAM)
BG (1) BG108193A (OSRAM)
BR (1) BR0208439A (OSRAM)
CA (1) CA2440468C (OSRAM)
CZ (1) CZ20032547A3 (OSRAM)
DO (1) DOP2002000356A (OSRAM)
EA (1) EA200300954A1 (OSRAM)
EC (1) ECSP034740A (OSRAM)
EE (1) EE200300480A (OSRAM)
GT (1) GT200200051A (OSRAM)
HU (1) HUP0303956A2 (OSRAM)
IL (1) IL157879A0 (OSRAM)
IS (1) IS6912A (OSRAM)
MA (1) MA27004A1 (OSRAM)
MX (1) MXPA03007437A (OSRAM)
NO (1) NO20034348D0 (OSRAM)
OA (1) OA12456A (OSRAM)
PA (1) PA8542101A1 (OSRAM)
PE (1) PE20021016A1 (OSRAM)
PL (1) PL369179A1 (OSRAM)
SK (1) SK11832003A3 (OSRAM)
SV (1) SV2003000928A (OSRAM)
TN (1) TNSN02038A1 (OSRAM)
UY (1) UY27233A1 (OSRAM)
WO (1) WO2002078747A2 (OSRAM)
ZA (1) ZA200306608B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
WO2007035890A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
DE102007019071A1 (de) 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010115612A2 (en) 2009-04-10 2010-10-14 Synthon B.V. Pregabalin compositions
WO2010150221A1 (en) 2009-06-25 2010-12-29 Wockhardt Research Centre Taste masked pharmaceutical compositions of pregabalin
HU230031B1 (hu) 2010-03-01 2015-05-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény
CN103494796B (zh) * 2013-09-30 2016-01-20 浙江华义医药有限公司 普瑞巴林稳定的药物组合物及其制备方法
CN104370986B (zh) * 2014-10-28 2017-07-04 河南中烟工业有限责任公司 糖衍生物烟用增香保润剂Mal‑Pro、制备方法及其应用
CN104311608B (zh) * 2014-10-28 2016-10-05 河南中烟工业有限责任公司 亲水型烟草增香保润剂Mal-Hyp、制备方法及其应用
CN105520918B (zh) * 2015-12-31 2018-12-11 常州市阳光药业有限公司 普瑞巴林胶囊
CN105434395B (zh) * 2015-12-31 2018-12-11 常州市阳光药业有限公司 普瑞巴林胶囊及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
FR2781793B1 (fr) * 1998-08-03 2001-07-20 Prographarm Lab Procede de fabrication de granules de gabapentine enrobes
KR100697734B1 (ko) * 1998-10-16 2007-03-22 워너-램버트 캄파니 엘엘씨 조증 및 양극성 장애 치료용 제약 조성물
IL155704A0 (en) * 2000-11-30 2003-11-23 Pfizer Prod Inc Combination of gaba agonists and sorbitol dehydrogenase inhibitors

Also Published As

Publication number Publication date
US7022678B2 (en) 2006-04-04
WO2002078747A8 (en) 2003-12-04
IS6912A (is) 2003-08-14
BG108193A (en) 2004-09-30
PA8542101A1 (es) 2002-10-28
US20020187941A1 (en) 2002-12-12
WO2002078747A2 (en) 2002-10-10
AP2003002873A0 (en) 2003-09-30
UY27233A1 (es) 2002-10-31
AR033024A1 (es) 2003-12-03
PL369179A1 (en) 2005-04-18
TNSN02038A1 (fr) 2005-12-23
OA12456A (en) 2004-08-24
PE20021016A1 (es) 2002-11-14
CA2440468C (en) 2008-09-02
MXPA03007437A (es) 2003-11-18
EA200300954A1 (ru) 2004-02-26
NO20034348L (no) 2003-09-29
ECSP034740A (es) 2003-12-24
WO2002078747A3 (en) 2003-10-09
EE200300480A (et) 2003-12-15
MA27004A1 (fr) 2004-12-20
EP1377318A2 (en) 2004-01-07
SK11832003A3 (sk) 2004-04-06
CN1511043A (zh) 2004-07-07
ZA200306608B (en) 2004-11-25
SV2003000928A (es) 2003-07-29
CA2440468A1 (en) 2002-10-10
BR0208439A (pt) 2004-03-23
JP2004524357A (ja) 2004-08-12
DOP2002000356A (es) 2002-12-15
CZ20032547A3 (en) 2004-04-14
NO20034348D0 (no) 2003-09-29
HUP0303956A2 (hu) 2004-04-28
GT200200051A (es) 2002-11-15
WO2002078747A9 (en) 2003-12-31
IL157879A0 (en) 2004-03-28

Similar Documents

Publication Publication Date Title
DE60129863T2 (de) Hydroxysubstituierte 2-Azetidinone verwendbar als Hypocholesterolemische Arzneimittel
US7022678B2 (en) Pregabalin lactose conjugates
EP1012154A2 (en) Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof
JP3004297B2 (ja) リゾスフィンゴ脂質誘導体
NL8803140A (nl) Adenosinederivaten.
HU202547B (en) Process for producing epipodophyllotoxin-glycoside-4'-phosphate derivatives and pharmaceutical compositions comprising such active ingredient
EP2943503B1 (en) Polymyxins, compositions, methods of making and methods of use
US5225529A (en) Synthetic amphiphilic glycoconjugates for neurological use
EP3330275A1 (en) Novel aminoglycoside antibiotic effective against multidrug-resistant bacteria
JPH01308282A (ja) ジデオキシジデヒドロ炭素環式ヌクレオシド
WO2014152718A1 (en) Saccharide conjugates
AU2019271799A1 (en) Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin
WO1987000174A2 (en) 1-o-phosphono-saccharides, method for the production and utilization thereof
US6242429B1 (en) Arabinosyladenine derivatives
Bozó et al. Synthesis of 4-cyanophenyl 2-deoxy-1, 5-dithio-β-d-threo-pentopyranoside
EP3735233A1 (en) Artemisinic acid glycoconjugate compounds, process for preparation and use thereof
Israel et al. Adriamycin analogs. 2. Novel anomeric ribofuranoside analogs of daunorubicin
AU2002236134A1 (en) Pregabalin lactose conjugates
EP0351784B1 (en) Therapeutic use of the isopropyl ester derivative of monosialoganglioside in nervous pathologies with an inflammatory component
EP0300960A2 (de) Neue pharmazeutische Präparate sowie neue Lactosylverbindungen und ihre Herstellung
DE68907857T2 (de) Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
HK1063151A (en) Pregabalin lactose conjugates
CA2322424A1 (en) 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
CA1058612A (en) Antibiotic and a process of preparing thereof
Cabaret et al. Synthesis of a lipodisaccharidic reagent for the chemical modification of enzymes

Legal Events

Date Code Title Description
A201 Request for examination
PA0105 International application

Patent event date: 20030929

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20030929

Comment text: Request for Examination of Application

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20050530

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20050818

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20050530

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I