KR20030088609A - 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용약제학적 조성물 - Google Patents
4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용약제학적 조성물 Download PDFInfo
- Publication number
- KR20030088609A KR20030088609A KR1020020026280A KR20020026280A KR20030088609A KR 20030088609 A KR20030088609 A KR 20030088609A KR 1020020026280 A KR1020020026280 A KR 1020020026280A KR 20020026280 A KR20020026280 A KR 20020026280A KR 20030088609 A KR20030088609 A KR 20030088609A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- oxaspiro
- butenyl
- methoxy
- hydroxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Description
피 검 균 | MIC(㎍/㎖) |
피티로스포룸 오발레 | < 2 ppm |
판단 결과 | |
실시예 3 | - |
실시예 4 | - |
실시예 5 | - |
실시예 6 | - |
실시예 7 | - |
실시예 8 | - |
실시예 9 | - |
판정 | 평점 |
○ | 0 내지 1.5 |
X | 1.5 내지 4.0 |
판정 | 평점 |
O | 0 내지 1.5 |
X | 1.5 내지 4.0 |
Claims (12)
- 약제학적으로 유효한 양의 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유함을 특징으로 하여 지루를 예방 또는 치료하기 위한 약제학적 조성물.
- 제1항에 있어서, 지루가 비듬인 약제학적 조성물.
- 제2항에 있어서, 지루가 단순성 피강진, 피강진, 연권상 피강진, 지루피부염 및 심상성 좌창으로 이루어진 그룹중에서 선택되는 약제학적 조성물.
- 제1항 내지 3항중 어느 한 항에 있어서, 바니싱 크림의 형태인 약제학적 조성물.
- 제1항 내지 3항중 어느 한 항에 있어서, 샴푸의 형태인 약제학적 조성물.
- 제1항에 있어서, 약제학적으로 유효한 양이 조성물의 0.1 중량% 내지 10 중량%인 약제학적 조성물.
- 약제학적으로 유효한 양의 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유하는 약제학적 조성물을 이를 필요로 하는 환자의 피부에 적용함을 특징으로 하여 지루를 예방 또는 치료하는 방법.
- 제7항에 있어서, 지루가 비듬인 방법.
- 제8항에 있어서, 지루가 단순성 피강진, 피강진, 연권상 피강진, 지루피부염 및 심상성 좌창으로 이루어진 그룹중에서 선택되는 방법.
- 제7항 내지 9항중 어느 한 항에 있어서, 바니싱 크림의 형태인 방법.
- 제7항 내지 9항중 어느 한 항에 있어서, 샴푸의 형태인 방법.
- 제7항에 있어서, 약제학적으로 유효한 양이 조성물의 0.01 중량% 내지 10 중량%인 방법.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020020026280A KR100564386B1 (ko) | 2002-05-13 | 2002-05-13 | 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용 약제학적 조성물 |
US10/514,373 US20050124690A1 (en) | 2002-05-13 | 2002-05-17 | Pharmaceutical composition for the treatment of seborrhea containing 4-hydroxy-5-methoxy-4-[2-methyl-3(3-methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one |
JP2004502994A JP2005530766A (ja) | 2002-05-13 | 2002-05-17 | 4−ヒドロキシ−5−メトキシ−4−[2−メチル−3−(3−メチル−2−ブテニル)−2−オキシラニル]−1−オキサスピロ[2,5]オクタン−6−オンを含有する脂漏症治療用医薬組成物 |
PCT/KR2002/000931 WO2003094908A1 (en) | 2002-05-13 | 2002-05-17 | A pharmaceutical composition for the treatment of seborrhea containing 4-hydroxy-5-methoxy-4-[2-methyl-3(3-methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one |
CNB028291913A CN1279901C (zh) | 2002-05-13 | 2002-05-17 | 用于治疗皮脂溢的含有取代的氧杂螺[2,5]辛烷的衍生物的药物组合物 |
CA002485380A CA2485380A1 (en) | 2002-05-13 | 2002-05-17 | A pharmaceutical composition for the treatment of seborrhea containing ovalicin |
AU2002256933A AU2002256933B8 (en) | 2002-05-13 | 2002-05-17 | A pharmaceutical composition for the treatment of seborrhea containing 4-hydroxy-5-methoxy-4-[2-methyl-3(3-methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one |
EP02726518A EP1509220A4 (en) | 2002-05-13 | 2002-05-17 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SEBORRHEA CONTAINING 4-HYDROXY-5-METHOXY-4- 2-METHYL-3- (3-METHYL-2-BUTENYL) -2-OXIRANYL -1-OXASPIRO 2,5 OCTANE-6-ONE |
RU2004136311/15A RU2282435C2 (ru) | 2002-05-13 | 2002-05-17 | Фармацевтический состав для профилактики или лечения себореи, способ профилактики или лечения себореи. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020020026280A KR100564386B1 (ko) | 2002-05-13 | 2002-05-13 | 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용 약제학적 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20030088609A true KR20030088609A (ko) | 2003-11-20 |
KR100564386B1 KR100564386B1 (ko) | 2006-03-27 |
Family
ID=29417355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020020026280A KR100564386B1 (ko) | 2002-05-13 | 2002-05-13 | 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용 약제학적 조성물 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20050124690A1 (ko) |
EP (1) | EP1509220A4 (ko) |
JP (1) | JP2005530766A (ko) |
KR (1) | KR100564386B1 (ko) |
CN (1) | CN1279901C (ko) |
AU (1) | AU2002256933B8 (ko) |
CA (1) | CA2485380A1 (ko) |
RU (1) | RU2282435C2 (ko) |
WO (1) | WO2003094908A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100447044B1 (ko) * | 2002-08-28 | 2004-09-07 | 주식회사 마이코플러스 | 오발리신을 함유하는 식물역병 방제용 조성물 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100528033B1 (ko) * | 2005-04-07 | 2005-11-15 | 주식회사 마이코플러스 | 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 아토피 피부염 치료용 약제학적 조성물 |
EP2167073A1 (en) * | 2007-06-14 | 2010-03-31 | Instituto Biomar S.A. | Terpenes with antifungal activity against malassezia yeasts |
AU2008316225B2 (en) | 2007-10-26 | 2014-06-19 | Avivagen Inc. | Compositions and methods for enhancing immune response |
KR101084734B1 (ko) | 2009-02-09 | 2011-11-22 | 한국과학기술연구원 | 옥사스파이로 화합 및 이 화합물의 제조방법 |
CA2975313C (en) | 2009-04-30 | 2020-06-30 | Avivagen Inc. | Methods and compositions for improving the health of animals |
FR2954124B1 (fr) * | 2009-12-18 | 2012-04-06 | Fabre Pierre Dermo Cosmetique | Utilisation du 2,3-dihydroxypropyl dodecanoate pour le traitement de la seborrhee |
GB201002356D0 (en) * | 2010-02-12 | 2010-03-31 | Reckitt Benckiser Nv | Composition |
FR2968560A1 (fr) * | 2010-12-13 | 2012-06-15 | Oreal | Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu |
US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
EP3313413A4 (en) | 2015-09-28 | 2018-07-11 | Azura Opthalmics Ltd. | Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion |
BR112018070852B1 (pt) | 2016-04-14 | 2024-01-16 | Azura Ophthalmics Ltd | Composições de dissulfeto de selênio |
CA3166357A1 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
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CH459467A (de) * | 1965-12-06 | 1968-07-15 | Sandoz Ag | Verfahren zur Herstellung eines neuen Antibioticums |
CH505811A (de) * | 1968-04-16 | 1971-04-15 | Sandoz Ag | Verfahren zur Herstellung eines bisher unbekannten Antibioticum-Derivates |
US3852443A (en) * | 1969-11-26 | 1974-12-03 | Colgate Palmolive Co | 2-mercaptoquinoxaline-1-oxides, salts thereof and-(1-oxoquinoxalinyl) disulfides for treating hair and skin |
US3881000A (en) * | 1971-09-08 | 1975-04-29 | Mundipharma Ag | Bis-(phosphorylated anthralin) compounds in the treatment of psoriasis and arthritis |
US3971725A (en) * | 1972-11-06 | 1976-07-27 | Colgate-Palmolive Company | 2-Mercaptoquinoxaline-1-oxides, salts thereof and 2-(1-oxoquinoxalinyl)disulfides in detergent compositions |
DE2430039C2 (de) * | 1974-06-22 | 1983-11-10 | Bayer Ag, 5090 Leverkusen | Climbazol in kosmetischen Mitteln |
JPS6040403B2 (ja) * | 1979-11-02 | 1985-09-11 | エスエス製薬株式会社 | フケ防止用の洗浄剤またはロ−シヨン |
GB8914024D0 (en) * | 1989-06-19 | 1989-08-09 | Fujisawa Pharmaceutical Co | Angiogenesis inhibitory composition comprising fr125756 and/or fr125035 substance,and process preparing the same |
FR2751217B1 (fr) * | 1996-07-16 | 2004-04-16 | Oreal | Utilisation de l'iodo-3 propynyl-2 butylcarbamate dans une composition cosmetique et/ou dermatologique comme actif pour le traitement de la seborrhee |
WO1999061432A1 (en) * | 1998-05-12 | 1999-12-02 | Biochem Pharma Inc. | Fumagillin analogs and their use as angiogenesis inhibitors |
US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
-
2002
- 2002-05-13 KR KR1020020026280A patent/KR100564386B1/ko active IP Right Grant
- 2002-05-17 WO PCT/KR2002/000931 patent/WO2003094908A1/en active Application Filing
- 2002-05-17 CA CA002485380A patent/CA2485380A1/en not_active Abandoned
- 2002-05-17 US US10/514,373 patent/US20050124690A1/en not_active Abandoned
- 2002-05-17 EP EP02726518A patent/EP1509220A4/en not_active Withdrawn
- 2002-05-17 JP JP2004502994A patent/JP2005530766A/ja active Pending
- 2002-05-17 CN CNB028291913A patent/CN1279901C/zh not_active Expired - Fee Related
- 2002-05-17 RU RU2004136311/15A patent/RU2282435C2/ru not_active IP Right Cessation
- 2002-05-17 AU AU2002256933A patent/AU2002256933B8/en not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100447044B1 (ko) * | 2002-08-28 | 2004-09-07 | 주식회사 마이코플러스 | 오발리신을 함유하는 식물역병 방제용 조성물 |
Also Published As
Publication number | Publication date |
---|---|
JP2005530766A (ja) | 2005-10-13 |
WO2003094908A1 (en) | 2003-11-20 |
EP1509220A4 (en) | 2009-04-01 |
RU2004136311A (ru) | 2005-05-27 |
RU2282435C2 (ru) | 2006-08-27 |
CN1279901C (zh) | 2006-10-18 |
AU2002256933B2 (en) | 2006-11-09 |
CN1627941A (zh) | 2005-06-15 |
AU2002256933A1 (en) | 2003-11-11 |
EP1509220A1 (en) | 2005-03-02 |
CA2485380A1 (en) | 2003-11-20 |
AU2002256933B8 (en) | 2009-06-18 |
KR100564386B1 (ko) | 2006-03-27 |
US20050124690A1 (en) | 2005-06-09 |
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