KR20020071853A - 테스트 샘플에서 분자 이벤트를 탐지 및 규명하는 시스템및 방법 - Google Patents

테스트 샘플에서 분자 이벤트를 탐지 및 규명하는 시스템및 방법 Download PDF

Info

Publication number
KR20020071853A
KR20020071853A KR1020027004757A KR20027004757A KR20020071853A KR 20020071853 A KR20020071853 A KR 20020071853A KR 1020027004757 A KR1020027004757 A KR 1020027004757A KR 20027004757 A KR20027004757 A KR 20027004757A KR 20020071853 A KR20020071853 A KR 20020071853A
Authority
KR
South Korea
Prior art keywords
signal
fluid
test
sample
response
Prior art date
Application number
KR1020027004757A
Other languages
English (en)
Korean (ko)
Inventor
로버트 지. 채프만
존 제이. 헤프티
바렛 제이. 바텔
마크 에이. 로데스
민 자오
Original Assignee
시그나츄어 바이오사이언스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시그나츄어 바이오사이언스 인코포레이티드 filed Critical 시그나츄어 바이오사이언스 인코포레이티드
Publication of KR20020071853A publication Critical patent/KR20020071853A/ko

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020027004757A 1999-10-13 2000-10-13 테스트 샘플에서 분자 이벤트를 탐지 및 규명하는 시스템및 방법 KR20020071853A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15917599P 1999-10-13 1999-10-13
US60/159,175 1999-10-13
US19170200P 2000-03-23 2000-03-23
US60/191,702 2000-03-23
PCT/US2000/028491 WO2001027610A2 (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample

Publications (1)

Publication Number Publication Date
KR20020071853A true KR20020071853A (ko) 2002-09-13

Family

ID=26855720

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027004757A KR20020071853A (ko) 1999-10-13 2000-10-13 테스트 샘플에서 분자 이벤트를 탐지 및 규명하는 시스템및 방법

Country Status (10)

Country Link
EP (1) EP1224453A2 (de)
JP (1) JP2003535310A (de)
KR (1) KR20020071853A (de)
CN (1) CN1425133A (de)
AU (3) AU8023500A (de)
CA (1) CA2386193A1 (de)
IL (1) IL149001A0 (de)
MX (1) MXPA02003815A (de)
NO (1) NO20021687L (de)
WO (1) WO2001027610A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989130B2 (en) 2003-01-20 2006-01-24 Samsung Electronics Co., Ltd. Method and automated fluidic system for detecting protein in biological sample

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586946B2 (en) * 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
WO2002066983A2 (en) * 2001-02-01 2002-08-29 Signature Bioscience, Inc. Bioassay device for detecting molecular events
AU2002238100A1 (en) * 2001-02-12 2002-08-28 Signature Bioscience, Inc. A system and method for characterizing the permittivity of molecular events
GB0117715D0 (en) * 2001-07-19 2001-09-12 Mrbp Res Ltd Microwave biochemical analysis
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
SG187992A1 (en) * 2001-07-25 2013-03-28 Univ Princeton Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
GB0328054D0 (en) * 2003-12-04 2004-01-07 Council Cent Lab Res Councils Fluid probe
GB0605273D0 (en) * 2006-03-16 2006-04-26 Council Cent Lab Res Councils Fluid robe
US10746680B2 (en) * 2006-11-16 2020-08-18 General Electric Company Sensing system and method
EP2604344A3 (de) 2007-03-28 2014-07-16 BioNano Genomics, Inc. Verfahren zur makromolekularen Analyse mittels Nanokanalanordnungen
GB0716202D0 (en) * 2007-08-11 2007-09-26 Microvisk Ltd Improved fluid probe
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
KR102090851B1 (ko) 2012-08-14 2020-03-19 10엑스 제노믹스, 인크. 마이크로캡슐 조성물 및 방법
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9567631B2 (en) 2012-12-14 2017-02-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
GB201219016D0 (en) * 2012-10-23 2012-12-05 Liverpool John Moores University Electromagnetic wave sensing
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9791453B2 (en) * 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9255321B2 (en) 2013-10-15 2016-02-09 Globalfoundries Inc. Directed surface functionalization on selected surface areas of topographical features with nanometer resolution
US9303310B2 (en) 2013-10-15 2016-04-05 International Business Machines Corporation Nanofluidic sensor comprising spatially separated functional sensing components
US10024851B2 (en) 2013-10-15 2018-07-17 International Business Machines Corporation Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices
CN106413896B (zh) 2014-04-10 2019-07-05 10X基因组学有限公司 用于封装和分割试剂的流体装置、系统和方法及其应用
US9921181B2 (en) 2014-06-26 2018-03-20 International Business Machines Corporation Detection of translocation events using graphene-based nanopore assemblies
EP3889325A1 (de) 2014-06-26 2021-10-06 10X Genomics, Inc. Verfahren zur analyse von nukleinsäuren aus einzelzellen oder zellpopulationen
MX2017005267A (es) 2014-10-29 2017-07-26 10X Genomics Inc Metodos y composiciones para la secuenciacion de acidos nucleicos seleccionados como diana.
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
TWI569017B (zh) * 2014-11-14 2017-02-01 Nippon Mektron Kk Coaxial probe holding mechanism and electrical characteristics check device
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
EP3262188B1 (de) 2015-02-24 2021-05-05 10X Genomics, Inc. Verfahren zur sequenzierung von nukleinsäuren in gesteuertem ausmass
CN113186256A (zh) 2015-04-10 2021-07-30 空间转录公司 生物样本的空间区别、多重核酸分析
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
ES2809127T3 (es) * 2015-12-23 2021-03-03 Viking Genetics Fmba Sistema RFID para identificación de pajillas criogénicas
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN108257052B (zh) * 2018-01-16 2022-04-22 中南大学 一种在线学生知识评估方法及其系统
EP3775271A1 (de) 2018-04-06 2021-02-17 10X Genomics, Inc. Systeme und verfahren zur qualitätskontrolle in einer einzelzellenverarbeitung
CN109192250B (zh) * 2018-08-01 2021-12-07 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
CN115598464A (zh) * 2022-10-08 2023-01-13 金华乐馨发制品有限公司（Cn） 一种电缆末端高低压电路的检测和修复装置及其方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519250A3 (en) * 1991-06-10 1993-06-02 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
AU7552194A (en) * 1993-07-26 1995-02-20 Phase Dynamics, Inc. System and method for monitoring substances and reactions
SE9700828D0 (sv) * 1997-03-07 1997-03-07 Asea Brown Boveri Förfarande och anordning för att bestämma ett flertal kvalitetsparametrar vilka beskriver tillståndet hos ett organiskt material
KR20010040559A (ko) * 1998-02-02 2001-05-15 시그나츄어 바이오사이언스 인코포레이티드 분자 결합 이벤트의 검출용 방법 및 장치

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989130B2 (en) 2003-01-20 2006-01-24 Samsung Electronics Co., Ltd. Method and automated fluidic system for detecting protein in biological sample

Also Published As

Publication number Publication date
CA2386193A1 (en) 2001-04-19
WO2001027610A3 (en) 2002-03-28
MXPA02003815A (es) 2002-09-30
WO2001027610A2 (en) 2001-04-19
WO2001027610A9 (en) 2002-08-01
IL149001A0 (en) 2002-11-10
AU2008203111A1 (en) 2008-08-07
AU8023500A (en) 2001-04-23
AU2005203756A1 (en) 2005-09-15
CN1425133A (zh) 2003-06-18
EP1224453A2 (de) 2002-07-24
NO20021687D0 (no) 2002-04-10
JP2003535310A (ja) 2003-11-25
NO20021687L (no) 2002-06-12

Similar Documents

Publication Publication Date Title
KR20020071853A (ko) 테스트 샘플에서 분자 이벤트를 탐지 및 규명하는 시스템및 방법
US6627461B2 (en) Method and apparatus for detection of molecular events using temperature control of detection environment
US20030032000A1 (en) Method for analyzing cellular events
US11016053B2 (en) Devices and methods for sample analysis
US20200256843A1 (en) Devices and methods for sample analysis
US6586946B2 (en) System and method for detecting and identifying molecular events in a test sample using a resonant test structure
US6461808B1 (en) Pipette-loaded bioassay assembly for detecting molecular or cellular events
US7083985B2 (en) Coplanar waveguide biosensor for detecting molecular or cellular events
US7993854B2 (en) Detection and quantification of biomarkers via a piezoelectric cantilever sensor
JP3693572B2 (ja) ナノ電極アレイ（ａｒｒａｙ）
Mendoza et al. High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA)
US6485905B2 (en) Bio-assay device
US20060121502A1 (en) Microfluidics apparatus for cantilevers and methods of use therefor
JP2005535881A (ja) 分子間相互作用のモニター方法及びシステム
Lu et al. Dissolution-enhanced luminescence enhanced digital microfluidics immunoassay for sensitive and automated detection of H5N1
WO2002066983A2 (en) Bioassay device for detecting molecular events
Jarrige et al. A fast intraoperative PTH point-of-care assay on the Philips handheld magnotech system
US7011948B2 (en) Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement
WO2002086475A2 (en) Method and apparatus for detection of molecular events using temperature control of detection environment
AU2012201441A1 (en) System and method for detecting and identifying molecular events in a test sample
US20090111117A1 (en) Device and method for detecting complex formation
US20020177175A1 (en) Coplanar waveguide biosensor for detecting molecular or cellular events
JP2009186202A (ja) センサー装置と標的物質検出法
WO2002077605A2 (en) Reentrant cavity bioassay for detecting molecular or cellular events

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid