WO2001027610A3 - System and method for detecting and identifying molecular events in a test sample - Google Patents

System and method for detecting and identifying molecular events in a test sample Download PDF

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Publication number
WO2001027610A3
WO2001027610A3 PCT/US2000/028491 US0028491W WO0127610A3 WO 2001027610 A3 WO2001027610 A3 WO 2001027610A3 US 0028491 W US0028491 W US 0028491W WO 0127610 A3 WO0127610 A3 WO 0127610A3
Authority
WO
WIPO (PCT)
Prior art keywords
test sample
detecting
signal
molecular events
test
Prior art date
Application number
PCT/US2000/028491
Other languages
French (fr)
Other versions
WO2001027610A2 (en
WO2001027610A9 (en
Inventor
Robert G Chapman
John J Hefti
Barrett J Bartell
Mark A Rhodes
Min Zhao
Original Assignee
Signature Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL14900100A priority Critical patent/IL149001A0/en
Application filed by Signature Bioscience Inc filed Critical Signature Bioscience Inc
Priority to CA002386193A priority patent/CA2386193A1/en
Priority to EP00970920A priority patent/EP1224453A2/en
Priority to AU80235/00A priority patent/AU8023500A/en
Priority to MXPA02003815A priority patent/MXPA02003815A/en
Priority to JP2001530570A priority patent/JP2003535310A/en
Priority to KR1020027004757A priority patent/KR20020071853A/en
Publication of WO2001027610A2 publication Critical patent/WO2001027610A2/en
Publication of WO2001027610A3 publication Critical patent/WO2001027610A3/en
Priority to NO20021687A priority patent/NO20021687L/en
Publication of WO2001027610A9 publication Critical patent/WO2001027610A9/en
Priority to AU2005203756A priority patent/AU2005203756A1/en
Priority to AU2008203111A priority patent/AU2008203111A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A molecular detection system for detecting the presence or absence of a molecular event within a test sample includes a fluid reservoir, a signal source, a measurement probe, and a signal detector. The measurement probe includes a probe head and a connecting end. The probe head is configured to electromagnetically couple an incident test signal to the test sample within the detection region of the fluid reservoir. The interaction of the incident test signal with the test sample produces a modulated test signal, at least a portion of which the probe head is configured to recover. The system further includes a signal detector that is coupled to the connecting end of the measurement probe and configured to recover the modulated test signal.
PCT/US2000/028491 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample WO2001027610A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2001530570A JP2003535310A (en) 1999-10-13 2000-10-13 Systems and methods for detecting and identifying molecular events in test samples
CA002386193A CA2386193A1 (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample
EP00970920A EP1224453A2 (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample
AU80235/00A AU8023500A (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample
MXPA02003815A MXPA02003815A (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample.
IL14900100A IL149001A0 (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in test sample
KR1020027004757A KR20020071853A (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample
NO20021687A NO20021687L (en) 1999-10-13 2002-04-10 System and method for detecting and identifying molecular events in a test sample
AU2005203756A AU2005203756A1 (en) 1999-10-13 2005-08-19 System and method for detecting and identifying molecular events in a test sample
AU2008203111A AU2008203111A1 (en) 1999-10-13 2008-07-14 System and method for detecting and identifying molecular events in a test sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15917599P 1999-10-13 1999-10-13
US60/159,175 1999-10-13
US19170200P 2000-03-23 2000-03-23
US60/191,702 2000-03-23

Publications (3)

Publication Number Publication Date
WO2001027610A2 WO2001027610A2 (en) 2001-04-19
WO2001027610A3 true WO2001027610A3 (en) 2002-03-28
WO2001027610A9 WO2001027610A9 (en) 2002-08-01

Family

ID=26855720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028491 WO2001027610A2 (en) 1999-10-13 2000-10-13 System and method for detecting and identifying molecular events in a test sample

Country Status (10)

Country Link
EP (1) EP1224453A2 (en)
JP (1) JP2003535310A (en)
KR (1) KR20020071853A (en)
CN (1) CN1425133A (en)
AU (3) AU8023500A (en)
CA (1) CA2386193A1 (en)
IL (1) IL149001A0 (en)
MX (1) MXPA02003815A (en)
NO (1) NO20021687L (en)
WO (1) WO2001027610A2 (en)

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US10150117B2 (en) 2014-04-10 2018-12-11 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10287623B2 (en) 2014-10-29 2019-05-14 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US12084716B2 (en) 2021-09-13 2024-09-10 10X Genomics, Inc. Methods and systems for processing polynucleotides

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US6586946B2 (en) 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
WO2002066983A2 (en) * 2001-02-01 2002-08-29 Signature Bioscience, Inc. Bioassay device for detecting molecular events
US20020168659A1 (en) * 2001-02-12 2002-11-14 Signature Bioscience Inc. System and method for characterizing the permittivity of molecular events
GB0117715D0 (en) * 2001-07-19 2001-09-12 Mrbp Res Ltd Microwave biochemical analysis
WO2003010289A2 (en) 2001-07-25 2003-02-06 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
KR100537504B1 (en) 2003-01-20 2005-12-19 삼성전자주식회사 An automated fluidic system for protein detection in biological samples
GB0328054D0 (en) * 2003-12-04 2004-01-07 Council Cent Lab Res Councils Fluid probe
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US10746680B2 (en) * 2006-11-16 2020-08-18 General Electric Company Sensing system and method
KR101522741B1 (en) 2007-03-28 2015-05-26 바이오나노 제노믹스, 인크. Methods of macromolecular analysis using nanochannel arrays
GB0716202D0 (en) * 2007-08-11 2007-09-26 Microvisk Ltd Improved fluid probe
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
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US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
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US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9791453B2 (en) * 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
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WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
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US9303310B2 (en) 2013-10-15 2016-04-05 International Business Machines Corporation Nanofluidic sensor comprising spatially separated functional sensing components
US10024851B2 (en) 2013-10-15 2018-07-17 International Business Machines Corporation Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices
US9255321B2 (en) 2013-10-15 2016-02-09 Globalfoundries Inc. Directed surface functionalization on selected surface areas of topographical features with nanometer resolution
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US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
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US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10150117B2 (en) 2014-04-10 2018-12-11 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US10287623B2 (en) 2014-10-29 2019-05-14 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US12084716B2 (en) 2021-09-13 2024-09-10 10X Genomics, Inc. Methods and systems for processing polynucleotides

Also Published As

Publication number Publication date
WO2001027610A2 (en) 2001-04-19
CA2386193A1 (en) 2001-04-19
NO20021687D0 (en) 2002-04-10
AU2005203756A1 (en) 2005-09-15
WO2001027610A9 (en) 2002-08-01
CN1425133A (en) 2003-06-18
IL149001A0 (en) 2002-11-10
KR20020071853A (en) 2002-09-13
MXPA02003815A (en) 2002-09-30
AU2008203111A1 (en) 2008-08-07
AU8023500A (en) 2001-04-23
NO20021687L (en) 2002-06-12
JP2003535310A (en) 2003-11-25
EP1224453A2 (en) 2002-07-24

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