KR20020063987A - Cosmetic composition having anti-irritation effect - Google Patents

Abstract

PURPOSE: A cosmetic composition prepared by using phytosterol which has excellent skin irritation reducing effects and is appliable to skin cosmetics is provided. Therefore, the composition is easy to formulate and has an effect on reducing skin irritation. CONSTITUTION: This cosmetic composition contains 0.01 to 20% by weight of phytosterol, based on the total weight of the cosmetic composition, wherein the phytosterol is one or two or more mixtures selected from the group consisting of beta-sitosterol, stigmasterol, campesterol, brassicasterol and avenasterol.

Description

Cosmetic composition with skin stimulating effect {COSMETIC COMPOSITION HAVING ANTI-IRRITATION EFFECT}

The present invention relates to a cosmetic composition, and more particularly to a cosmetic composition excellent in skin irritation relief.

The skin is an organ that is in constant contact with the external environment. Its main function is to act as a protective barrier against water loss.

The stratum corneum of the epidermis is located on the outermost side of the skin and suppresses the loss of moisture and electrolytes out of the skin, thereby preventing the drying of the skin and providing a normal biochemical metabolism of the skin. In addition, it plays an important role in protecting the human body from external physical damage and chemicals or preventing the invasion of bacteria and viruses into the skin.

These skins are damaged by exposure to substances that cause skin irritation, such as sodium lauryl sulfate, dimethyl sulfoxide, croton oil, and sodium hydroxide. Transepidermal Water Loss, an indicator of damage, increases.

Modern people are exposed to a lot of irritants in their daily lives, and skin is often irritated by the frequent use of synthetic surfactants contained in detergents and latex products.

As such, studies have been conducted to alleviate the irritation by protecting the skin against substances causing skin irritation. Oil-in-Water emulsions containing glycerin have been shown to protect the skin against skin irritation by sodium lauryl sulfate or dimethyl sulfoxide (Bettiger J et al. Dermatology. 1998), It has also been reported that Protective Cream has a skin irritant effect on chronic skin irritation (Walter Wigger-Alberti et al. J Am Acad Dermatol. 1999).

Phytosterols are generic to vegetable sterols in alcohols having a cyclopentano hydrophenanthrene ring and include many types of sterols. Among them, representative phytosterols include beta-Sitosterol, Stigmasterol, Campesterol, Brassicasterol, Avenasterol, Typhasterol, and Spinasterol. ), Ergosterol, Diosgenin and the like.

Japanese Patent Laid-Open No. 2000-103727 discloses that the phytosterol as described above is effective in moisturizing the skin by using it as a component of the skin moisturizing composition. In addition, Patent No. 1992-5646 discloses a cosmetic composition containing lysophospholipids and sphingolipids and having excellent skin moisturizing properties and skin stability to which phytosterol is added to secure their long-term emulsion stability.

However, the use of phytosterols as a skin irritant is not known.

It is an object of the present invention to confirm that phytosterol has an excellent skin stimulating effect, and to provide a skin stimulating alleviating cosmetic composition prepared using phytosterol which is excellent in stimulating effect on irritants and can be applied to skin cosmetics. .

The present invention for achieving the above object relates to a cosmetic composition having a skin irritation-releasing effect containing 0.01 to 20% by weight of phytosterol relative to the total weight of the cosmetic composition.

Hereinafter, the present invention will be described in detail.

In the present invention, phytosterols, which are skin stimulation-releasing substances, are added to a conventional cosmetic composition to form a skin stimulation-releasing cosmetic composition.

In the present invention, phytosterol may be used in general phytosterol, but it is preferable to use those extracted from soybean, Rape Seed or wood. Especially, it is especially preferable to use commercial products, such as Generol of Henkel, Germany, phytosterol of Canada Pitochem, and phytosterol of Japan Aiza.

In addition, as phytosterol, it is preferable to use one or a mixture of two or more selected from beta sitosterol, stigmasterol, campestrol, bracisterol and avenasterol. Phytosterols, such as tifasterol, spinasterol, ergosterol, and diosgenin, can also be used, but they are contained in a very small amount in plants, so they are very expensive to separate and use.

The phytosterol is preferably added 0.01 to 20% by weight based on the total weight of the cosmetic composition. When phytosterol is added in an amount less than 0.01% by weight based on the total weight of the cosmetic composition, irritation-releasing effect does not appear, and when added in excess of 20% by weight, it is difficult to formulate. The phytosterol is particularly preferably added to 1 to 5% by weight based on the total weight of the cosmetic composition, in this range is excellent in stimulating effect and easy to formulate.

The present invention will be described in more detail based on the following examples. The following examples are intended to facilitate the understanding of the present invention and do not limit the scope of the present invention.

(Example 1)

Preparation of Nutritious Cosmetic Water (Milk Lotion)

Using the ingredients in Table 1 below, nutrient longevity (mild lotion) containing phytosterol was prepared.

division Raw material name content One Purified water Up to 100 2 glycerin 5.0 3 1,3 butylene glycol 4.0 4 Carboxyvinyl Polymer 0.2 5 Methyl paraben 0.1 6 Profile paraben 0.1 7 Floating paraffin 10.0 8 Mono stearin polyoxy ethylene sorbitan (20E.O) 0.7 9 Self-emulsifying glycerin monostearate 1.3 10 Cetanol 0.5 11 Stearic acid 0.7 12 Phytosterol 2.0 13 Triethanol amine 0.2 14 incense 0.1

First, after mixing and weighing the raw materials 1 to 5, the solution A was obtained by heating and dissolving at 80 ° C., and separately weighing the raw materials 6 to 12 and dissolving it to 80 ° C. to obtain solution B.

The solution B was added to solution A to emulsify and then neutralized by adding a neutralizing agent of raw material 13, and then cooled to 40 ° C. After cooling, the raw material 14 was added and cooled to 35 ° C to obtain a desired lotion-like cosmetic.

(Comparative Example 1)

Using the components of Table 2 below to prepare a nutrient lotion (mild lotion) of Comparative Example 1.

division Raw material name content One Purified water Up to 100 2 glycerin 5.0 3 1,3 butylene glycol 4.0 4 Carboxyvinyl Polymer 0.2 5 Methyl paraben 0.1 6 Profile paraben 0.1 7 Floating paraffin 10.0 8 Mono stearin polyoxy ethylene sorbitan (20E.O) 0.7 9 Self-emulsifying glycerin monostearate 1.3 10 Cetanol 0.5 11 Stearic acid 0.7 12 Triethanol amine 0.2 13 incense 0.1

First, after mixing and weighing the raw materials 1 to 5, the solution A was obtained by heating and dissolving at 80 ° C., separately weighing the raw materials 6 to 11 and heating and dissolving to 80 ° C. to obtain solution B.

The solution B was added to solution A to emulsify and neutralized by adding a neutralizing agent 12, and then cooled to 40 ° C. After cooling, the raw material 13 was added and cooled to 35 ° C to obtain a desired lotion-like cosmetic.

Experimental Example 1

Experiment of Stimulation Relaxation Effect

In order to evaluate the stimulating effect of phytosterol, the phytosterol-containing emulsion of Example 1 and the phytosterol-containing emulsion of Comparative Example 1 were pretreated and then compared with how much stimulation was suppressed when contacted with a stimulant.

The experimental methods and procedures followed the procedure of the paper (Walter Wigger-Alberti et al. J Am Acad Dermatol. 1999), which tested the effect of protective creams on irritants.

20 healthy adult men and women (10 males, 10 females) were applied to the inner soft skin of the upper arm, 0.03 ml of the fluid of Example 1 and the fluid of Comparative Example 1 were applied so as to have a diameter of about 2 cm.

After 30 minutes of application, 10% sodium lauryl sulfate, which is a stimulant, was attached to a pin chamber (diameter 12 mm. Epitest Ltd Oy. Finland) for 30 minutes and then removed. One hour after removal, the degree of stimulation was assessed by visual observation, measurement of epidermal moisture loss, and erythema index.

All the above experiments were carried out at the same place with a temperature of 22 ± 2 ℃, relative humidity 55-60%.

(1) Visual observation

The evaluation method was divided into six grades as follows. The evaluation results are shown in Table 3 below.

0: no reaction

1: very slight erythema

2: slight erythema

3: erythema, border edema, papule

4: erythema, edema

5: severe erythema, edema, blisters

Subject Example 1 Comparative Example 1 One One 2 2 One 2 3 One 2 4 2 3 5 One 3 6 0 2 7 2 2 8 One 2 9 One 2 10 One 3 11 One One 12 One 2 13 2 3 14 One One 15 One 2 16 One 3 17 2 2 18 One 2 19 0 3 20 One 2 Average observation 1.0 2.2

As can be seen from the results of Table 3, the lotion containing the phytosterol of the present invention (Example 1) was superior to the skin irritation-releasing effect compared to the lotion without the conventional phytosterol (Comparative Example 1).

(2) Transepidermal Water Loss (TEWL)

When the skin is irritated, the stratum corneum is damaged and the epidermal moisture loss is increased. Therefore, the epidermal moisture loss measuring device (Tewameter TM-210, Courage + Khazaka Koln, Germany) is used to measure the hard epidermal moisture loss. Evaluated.

The results are shown in Table 4 below, and the unit is mg / m 2 / hr.

Subject Example 1 Comparative Example 1 One 12.5 18.5 2 16.7 19.0 3 15.3 20.1 4 17.9 21.0 5 13.4 20.5 6 11.5 18.5 7 15.5 18.9 8 13.6 18.3 9 14.5 18.8 10 13.7 20.3 11 12.1 17.4 12 12.5 17.5 13 15.4 19.8 14 13.1 18.8 15 14.2 18.5 16 13.7 21.5 17 15.7 19.3 18 14.8 19.1 19 12.5 20.7 20 13.6 19.5 Average measurement value 14.1 19.3

As can be seen from the results of Table 4, when the lotion containing the phytosterol of the present invention (Example 1) was used, the amount of hard epidermal moisture loss was reduced compared to the case where the lotion without the conventional phytosterol (Comparative Example 1) was used. Showed results. Therefore, it can be seen that the lotion containing the phytosterol of the present invention is a cosmetic having excellent skin stimulating effect.

(3) Erythema Score

When the skin is irritated, erythema, blisters, and redness of the skin become red. The degree of redness can be measured using a colorimeter (Chromameter CR-300, Minolta, Japan).

The erythema index is expressed in three dimensions of L * a * b *. Among them, the a * value, which is a value between red (pasitive value) and green (negative value), was measured. The results are shown in Table 5 below.

Subject Example 1 Comparative Example 1 One 6.89 7.97 2 7.21 8.21 3 7.36 8.17 4 7.40 8.46 5 6.54 7.80 6 6.40 7.06 7 7.42 8.17 8 6.88 8.54 9 6.96 8.36 10 7.10 8.27 11 7.26 7.47 12 7.11 7.76 13 7.57 8.77 14 6.87 7.56 15 6.96 7.99 16 6.71 8.54 17 7.60 8.12 18 7.01 8.07 19 6.72 8.89 20 6.91 8.24 Average measurement value 7.04 8.12

As can be seen from the results of Table 5, the lotion containing phytosterol of the present invention (Example 1) showed an excellent stimulating effect compared to the lotion without the conventional phytosterol (Comparative Example 1).

(Example 2)

Preparation of Nutritional Cream

Nutritional cream containing phytosterol was prepared in the same manner as in Example 1 using the ingredients shown in Table 6.

division Raw material name content One Purified water Up to 100 2 glycerin 5.0 3 1,3 butylene glycol 4.0 4 Carboxyvinyl Polymer 0.15 5 Methyl paraben 0.1 6 Profile paraben 0.1 7 Floating paraffin 10.0 8 Mono stearin polyoxy ethylene sorbitan (20E.O) 0.7 9 Self-emulsifying glycerin monostearate 1.3 10 Cetanol 2.0 11 Stearic acid 2.0 12 Phytosterol 3.0 13 Triethanol amine 0.2 14 incense 0.1

(Comparative Example 2)

Using the ingredients in Table 7, the nutrition cream of Comparative Example 2 containing no physterol was prepared in the same manner as in Comparative Example 1.

division Raw material name content One Purified water Up to 100 2 glycerin 5.0 3 1,3 butylene glycol 4.0 4 Carboxyvinyl Polymer 0.15 5 Methyl paraben 0.1 6 Profile paraben 0.1 7 Floating paraffin 10.0 8 Mono stearin polyoxy ethylene sorbitan (20E.O) 0.7 9 Self-emulsifying glycerin monostearate 1.3 10 Cetanol 2.0 11 Stearic acid 2.0 12 Triethanol amine 0.2 13 incense 0.1

Experimental Example 2

Stimulation Relaxation Effect Experiment

For Example 2 and Comparative Example 2, the stimulation relaxation effect was tested in the same manner as in Experimental Example 1.

(1) Visual observation

The visual observations of Example 2 and Comparative Example 2 are shown in Table 8 below.

Subject Example 2 Comparative Example 2 One One 2 2 One One 3 0 2 4 One 2 5 One 2 6 0 2 7 One 2 8 One 2 9 One One 10 0 2 11 One One 12 One 2 13 2 2 14 0 One 15 One 2 16 One 3 17 One 2 18 One 2 19 0 3 20 One 2 Average observation 0.8 1.9

As can be seen from the results of Table 8, the nourishing cream containing phytosterol of the present invention (Example 2) was superior to the skin irritation-releasing effect compared to the nourishing cream containing no conventional phytosterol (Comparative Example 2).

(2) Measurement of hard epidermal moisture loss

The results obtained by measuring the amount of hard epidermal moisture loss in Example 2 and Comparative Example 2 are shown in Table 9 below. The unit is mg / m 2 / hr.

Subject Example 2 Comparative Example 2 One 12.0 18.3 2 13.5 19.0 3 12.6 19.1 4 13.9 19.9 5 13.5 19.5 6 11.0 19.0 7 13.0 18.0 8 12.7 17.5 9 12.8 18.5 10 13.0 18.3 11 12.1 16.5 12 12.0 17.0 13 12.3 19.0 14 13.0 18.3 15 12.5 18.9 16 11.9 19.5 17 13.2 18.3 18 12.5 18.7 19 10.9 19.4 20 11.7 19.0 Average measurement value 12.5 18.5

As can be seen from the results of Table 9, when the nutrient cream containing phytosterol of the present invention (Example 2) was used, the amount of hard epidermal moisture loss compared to the case of using the conventional nutrient cream without phytosterol (Comparative Example 2) This showed a decreasing result. Therefore, it can be seen that the nutrient cream containing phytosterol of the present invention is a cosmetic having excellent skin stimulating effect.

(3) Erythema Score

The erythema index was measured for Example 2 and Comparative Example 2, and the results are shown in Table 10 below.

Subject Example 1 Comparative Example 1 One 6.77 8.10 2 7.24 7.96 3 6.37 8.10 4 6.70 8.17 5 6.46 7.86 6 6.27 7.72 7 5.96 7.46 8 6.43 7.97 9 6.57 7.66 10 6.14 7.89 11 6.46 8.16 12 6.47 7.67 13 7.01 7.96 14 6.04 7.54 15 6.27 7.94 16 6.83 8.18 17 6.77 8.07 18 6.23 7.85 19 5.87 8.64 20 6.36 8.17 Average measurement value 6.46 7.95

As can be seen from the results of Table 10, the nutrient cream containing phytosterol of the present invention (Example 2) showed an excellent stimulating effect compared to the nutrient cream containing no conventional phytosterol (Comparative Example 2).

As described above, phytosterol can be applied to skin cosmetics and shows excellent irritation-releasing effect when formulated in cosmetics, and the phytosterol-containing cosmetic composition of the present invention has excellent irritation-releasing effect on irritants.

Claims (2)

A cosmetic composition having a skin stimulating effect containing 0.01 to 20% by weight of phytosterol relative to the total weight of the cosmetic composition. The method of claim 1, The phytosterol is a cosmetic composition having a skin stimulating effect, characterized in that one or a mixture of two or more selected from the group consisting of beta sitosterol, stigmasterol, campestrol, brassicasterol and avenasterol.