JP2001002574A - Accelerator for recovering skin barrier function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject accelerator capable of recovering reduced skin barrier function remarkably in a short time by containing phytosterol. SOLUTION: This accelertor for recovering skin barrier function contains phytosterol. Phytosterol is a mixture of plant originated sterols and mainly contains β-sitosterol, campesterol, stigmasterol, etc. To accelerate recovering of skin barrier function means to have an accelerating effect in a TEWL recovery factor with a clearly significant difference when TEWL values at every measuring time are compared with the value without any treatment by bringing the TEWL value after 1 hour of tape stripping of the skin to be 0% and the value before the tape stripping to be 100%. The accelerator can be added to cosmetics, medicines and quasi-drug baes. The amount to be added is preferably 0.1-20 wt.% in the whole amount of the aforesaid cosmetic and the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an agent for promoting the recovery of skin barrier function. More specifically, the present invention relates to a skin barrier function recovery promoter useful for promoting recovery of skin barrier function and preventing epidermal hyperplasia due to a decrease in skin epidermal function.

[0002]

2. Description of the Related Art It is known that in skin roughening symptoms seen in various skin diseases and the like, the loss of moisture from the skin is more active than in healthy skin. It has been considered that the increase in the so-called transdermal water loss (hereinafter also referred to as TEWL) involves the reduction of components that are considered to be responsible for water retention and barrier function in the epidermis. Was.

Therefore, NMF (Natural Moisturizi) has been conventionally used as an active ingredient having an effect of improving and preventing skin diseases and rough skin from the viewpoint of replenishing the skin with an intra-epidermal component having a moisture retaining function and a skin barrier function.
Amino acids as ng Factor), lipids as keratinocyte intercellular lipids, and other mucopolysaccharides such as hyaluronic acid or similar substances have been added to cosmetics and external preparations for skin because of their high safety.

[0004] Recently, it has been reported that a specific substance that activates the biosynthesis of an intraepidermal component that is responsible for the skin barrier function has an effect of improving skin roughness (Japanese Patent Laid-Open No. 9-2952). No.).

[0005]

However, although many studies have been made on substances having an effect of improving and preventing rough skin, studies on substances having an effect of improving or recovering the skin barrier function are not sufficient. Since the relationship between the effect of improving the barrier function and the effect of improving and preventing rough skin is not clear, a substance having the effect of improving and preventing rough skin does not necessarily have the effect of improving the skin barrier function.

[0006] On the other hand, it has been reported that when the skin barrier function is reduced, the epidermal function of the skin is reduced and abnormal epidermal proliferation is caused. In particular, in the case of elderly people, it takes a long time to recover the reduced skin barrier function, and a new skin barrier function that is effective to prevent epidermal hyperproliferative abnormalities due to a decrease in skin epidermal function with aging The development of a recovery accelerator was requested.

[0007] In view of the above circumstances, the present inventors have conducted extensive research on substances having a reduced skin barrier function, that is, substances which act rapidly on changes in TEWL. The present inventors have found a new finding of recovery within a short time and have completed the present invention.

[0008] It is an object of the present invention to provide a novel skin barrier function recovery promoter capable of recovering a reduced skin barrier function in an extremely short time.

[0009]

That is, the present invention provides a skin barrier function recovery promoting agent comprising phytosterol.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The phytosterol used in the present invention is a mixture of plant-derived sterols, which contains β-sitosterol, campesterol, stigmasterol and the like as main components, and is a substance which is conventionally known as a component of a skin external preparation or cosmetic. It has never been reported that it has an effect of promoting the recovery of the skin barrier function, and this is the first effect found by the present inventors.

In the present invention, promoting the recovery of the skin barrier function is described in detail later. Each measurement was performed by setting the TEWL value of the skin 1 hour after tape stripping to 0% and the value before tape stripping to 100%. The value of TEWL at time showed a significant difference when compared to the state where nothing was applied, meaning that it had an effect of promoting the recovery rate of TEWL, and the method of Andrew et al. (J Invest Dermatol, 86; 598, 1986), which is different from the so-called skin roughness improvement prevention effect in which skin is treated with a Cotton ball impregnated with a 4% aqueous solution of sodium dodecyl sulfate (SDS) to make a judgment.

The skin barrier function recovery promoter of the present invention comprises:
It can be applied to the skin as a cosmetic, pharmaceutical, quasi-drug, for example, as a cosmetic, pharmaceutical, quasi-drug base, for example, ointment, cream, emulsion, lotion, pack, bath agent, etc. . The amount is not particularly limited, but is preferably 0.1 to 20% by weight based on the total amount of the cosmetics and the like.

[0014]

Next, the present invention will be described in more detail with reference to examples, but the technical scope of the present invention is not limited to these examples. The compounding amount is% by weight.

The effect of promoting the recovery of the skin barrier function was evaluated by the following method, and the results are shown in FIG.

"Skin Barrier Function Recovery Acceleration Effect Test" The effect of a phytosterol-containing sample on the process in which the skin barrier function destroyed by stripping the skin to the original state is restored using TEWL as an index. Was evaluated. That is, the experiment was performed on the inner part of the forearm of 10 male panels. T
EWL was measured with TEWAMETER TM-200 (COURAGE + KHAZAKA). After measuring the TEWL of the target site in advance, a cellophane tape was applied, immediately peeled off, and this operation was repeated 10 times. One hour after this operation, the TEWL of the site was measured. A sample in which phytosterol was blended at a ratio of 2% by weight to a base of propylene glycol: ethanol = 7: 3 was applied so as to be 50 μl per 6 cm ² . In addition, as a control, only the above-mentioned base was applied to the site where tape stripping was performed in the same manner. TEWL was measured again 3 hours after sample application. The TEWL before 3 hours after the tape stripping is 0%, and the TEWL before the sample application 1 hour after the tape stripping is 100%.
The relative value of the EWL measurement value was calculated, and the recovery promoting effect was evaluated. FIG. 1 shows the results of calculating the average value of 10 subjects and comparing the phytosterol application group with the base application only group.

In this evaluation method, a TEWL relative value of 0% means that the TEWL is completely recovered. Therefore, it is judged that the phytosterol-containing sample significantly accelerated the recovery of TEWL as compared to the control base.

Examples of the formulation of the skin barrier function recovery promoter of the present invention are described below.

"Cream" (formulation)% by weight Solid paraffin 5.0 Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 2 0.2 Soap powder 0.1 Borax 0.2 Phytosterol 1.0 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Production method) Phytosterol, soap powder,
Borax was added and heated to 70 ° C. (aqueous phase). Also,
The other components were mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase was gradually added to the aqueous phase with stirring, and after the addition was completed, the temperature was maintained for a while to cause a reaction. Thereafter, the mixture was uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well to obtain a cream.

"Jelly" (formulation) weight% 95% ethanol 10.0 dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 3.0 carboxyvinyl polymer 0.05 (trade name: Carbopol 940, BFGoodrich Chemical co
mpany) Sodium hydroxide 0.15 Phytosterol 1.0 Sodium bisulfite 0.01 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Preparation method) Carboxyvinyl polymer is uniformly dissolved in ion-exchange water, and polyoxyethylene (50 Mol) oleyl alcohol ether was added to the aqueous phase. Next, after adding other components, the mixture was neutralized with sodium hydroxide and phytosterol to increase the viscosity, thereby obtaining a jelly.

"Pack" (formulation)% by weight (phase A) dipropylene glycol 5.0 polyoxyethylene (60 mol) hydrogenated castor oil 5.0 phytosterol 1.0 (phase B) olive oil 5.0 tocopherol acetate 0. 2 Ethylparaben 0.2 Fragrance 0.2 (Phase C) Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, Polymerization degree 2000) Ethanol 7.0 Deionized water Residue (Production method) A phase, B phase , C phase are uniformly dissolved,
Phase B was added to solubilize. Next, after adding the phase C to this, filling was performed to obtain a pack.

[0022]

According to the present invention, it is possible to provide an excellent skin barrier function recovery promoter which can promote the recovery of skin barrier function.

[Brief description of the drawings]

FIG. 1 is a graph showing the effect of promoting the recovery of phytosterol on the skin barrier function evaluated using TEWL as an index.

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Claims (1)

[Claims] 1. A skin barrier function recovery promoter comprising phytosterol.