KR20010057429A - Skin care composition containing Ursolic acid - Google Patents

Abstract

The present invention relates to a cosmetic composition containing ursolic acid together with retinol, which is an existing cosmetic ingredient.

The cosmetic composition of the present invention can significantly improve the skin improvement effect of retinol by containing ursolic acid, and solve the safety and stability problems of the cosmetics containing retinol.

In the cosmetic composition of the present invention, the retinol is contained in an amount of 0.001 to 10.0% by weight, preferably 0.05 to 2.0% by weight, and ursolic acid is 0.01 to 5.0% by weight, based on the total weight of the cosmetic. Preferably in an amount of 0.1 to 2.0% by weight.

Description

Cosmetic composition containing ursolic acid {Skin care composition containing Ursolic acid}

The present invention relates to a cosmetic composition containing ursolic acid together with retinol.

In most people's growth, the skin responds easily to daylight, but as the age increases, the skin tissue gradually changes, making it difficult to respond to daylight, causing wrinkles, thickening of the skin, sagging skin, loss of skin elasticity, Skin roughness, skin dryness, and skin stains may occur. The result of the accumulation of these effects of sunlight is "photoaging". When the epidermis and dermal tissue changes due to photoaging of the skin, wrinkles are formed, the skin becomes yellowish, the skin becomes thicker and elasticity gradually decreases.

Examples of using retinoid (vitamin A) to solve the problem related to skin aging are disclosed in US Patent Publication No. 4603146, 4877805 and the like.

Retinoids used in skin care cosmetics include Retinol: Vitamin Aalcohol, Retinal: Vitamin A aldehyde, Retinyl acetate, Retinyl propionate, Retinyl linoleate and Retinyl palmitate. Of these, retinol is an endogenous compound that exists naturally in the human body and is essential for the differentiation and growth of epithelial tissue. In addition, retinol has very high safety compared to retinoids such as retinoic acid, and thus can be said to be very suitable as a raw material for skin improvement cosmetics.

Recently, there is a growing interest in skin protection agents containing retinoids. For example, retinol, a vitamin A, has a high therapeutic effect on acne, so many products in the form of skin ointments are produced and easily purchased by the general consumer. The situation is using. In addition, retinol has recently been found to have a wide range of effects as well as healing acne has been tried to apply it. Representative of such effects include the prevention of photoaging and the treatment of skin damaged by sunlight.

However, although retinol is very effective in improving and preventing skin wrinkles and healing acne, discoloration and discoloration occur when prescribed in the product, and the effect decreases over time, and the effect decreases even when a small amount is used. Due to problems such as skin irritation, its use has been extremely limited in cosmetics.

Therefore, there have been many attempts to solve the above problems with retinol by adding other ingredients with retinol in cosmetics. So far, examples of adding other substances to stabilize the retinol are useful oxidizing agents. There is a patent for the oil-in-water (O / W) emulsifier type stabilized by containing Retinoic acid with BHT, dl-α-tocopherol and EDTA chelating agent (US Pat. No. 3,906,108). There is a patent for oil-in-water emulsifier type (US Patent 4,247,547) that stabilizes the retinol by using the oil-in-water type emulsifier type that is stabilized by containing retinol, retinyl acetate, retinyl palmitate using oil-soluble oxidizing agents BHT and BHA. (US Pat. No. 4,826,828) and retinol as antioxidants BHA, ascorbic acid, tocopheryl There is a water-in-oil type patent (US Pat. No. 4,720,353) stabilized using nooleate, and an oil-in-water emulsion containing at least one water-soluble antioxidant, at least one oil-soluble antioxidant, and a chelating agent to improve the chemical stability of the retinoid. (European Patent 0440,398 BI) has been published, European Patent 1568106A1 is a system for stabilizing retinoids, chelating and oil-soluble antioxidants, chelating and water-soluble antioxidants, antioxidants present in the oil phase and water phase of the emulsion and An oil-in-water emulsion composition containing free base imidazole has been reported.

Looking at the various patents, it can be seen that the purpose of stabilizing the retinol and its derivatives by changing the type of oil-soluble antioxidants and chelating agents according to the emulsification form.

The present inventors have made a lot of research and efforts to solve the above problems, as a result of the patent application to develop a cosmetic composition that maintains a high functional effect for a long time by stabilizing a double unstable high functional useful active material in the prior art. (Domestic Patent Application 97-47262,47276)

Meanwhile, most of the ingredients currently developed as cosmetics such as AHA and vitamin C, including retinol, have problems such as weak clinical efficacy effects and prolonged period of use required for visible clinical results, in addition to the safety and stability problems described above. . In particular, retinol has the effect of effectively improving the appearance of thick wrinkles against the reduction of skin elasticity and wrinkle formation caused by the collapse of the collagen bundle of skin dermis due to photoaging, but the collagen bundle structure, skin elasticity and Fine wrinkles are hardly improved, and thus, the time required for wrinkle improvement by using retinol is inevitably prolonged.

An object of the present invention is to improve the existing effects of retinol and to improve the problems of cosmetics containing retinol. Specifically, the purpose of the present invention is to improve the skin wrinkles, blemishes, freckles, such as pigmentation, pigmentation improvement, skin elasticity enhancement, whitening effect and moisturizing effect, etc., while retaining the efficacy of the retinol as a cosmetic, weak and visible clinical efficacy It is to provide a cosmetic composition that overcomes problems such as prolongation of the period of use necessary for clinical results.

In order to achieve the above object, the present invention has the effect of improving the fine wrinkles (fine wrinkles) unlike the retinol together with the retinol having the effect of improving the deep wrinkles (appearing wrinkles) by photoaging as an existing skin improvement component. It is carried out to provide a cosmetic composition containing ursolic acid that will have an enhancing effect.

The present invention relates to a cosmetic composition containing ursolic acid together with retinol, thereby improving the skin beauty effect of retinol and improving the problem as a cosmetic having retinol.

The present inventors are ursolic acid (Ursolic acid) treatment for acne, skin wrinkle improvement, prevention of skin aging by the antioxidant effect, improvement of pigmentation such as blemishes, freckles, black mushrooms, treatment of damaged skin, sun protection, etc. The present invention has been found to significantly improve the effects of retinol, which is widely used in cosmetics, and to effectively solve problems such as weak clinical efficacy and prolonged period of use required for visible clinical results. .

Ursolic acid ((3β) -3-Hydroxyurs-12-en-28-oic acid), C ₃₀ H ₄₈ O ₃ : molecular weight 456.68] used in the present invention is known as Urson, Prunol, Micromrol, malol, etc. It is a pentacyclic triterpenoid complex contained in vegetables, herbs, etc., and is known to be excellent in photoaging skin improvement (wrinkle improvement, elasticity improvement) and anti-inflammatory effect (JP09143050, 09118611,1997.).

Ursolic acid, like most triterpenoids, is widely distributed in plants and contains various derivatives, including the isomeric oleanolic acid [(3β) -3-Hydroxyolean-12-en-28-oic acid]. Ursolic acid, in particular, has the same pharmacological effects as the anti-cancer (skin cancer), anti-inflammatory, anti-ulcer, hepatoprotective, and antibacterial effects of Oleanolic acid. The discovery of ursolic acid in cosmetics began by separating it from the wax coating components on the fruit's surface, such as apples, pears, cranberries, and plums.

Plants containing such ursolic acid are known to contain a large amount of Lamiaceae family, such as Rosemarinus officinalis L., Lavendula augustifolia Mill., Oreganum vulgare L., Thymus vulgare L.

The cosmetic composition of the present invention is not particularly limited in the formulation, for example, softening longevity, astringent longevity, nourishing longevity, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence It may have a dosage form, such as a pack.

In addition, in the cosmetic composition of each formulation, it is difficult for those skilled in the art to include ingredients other than retinol and ursolic acid as skin raw materials including retinol and ursolic acid as described above. It can be selected and formulated without any enemy.

Retinol in the cosmetic composition of the present invention is contained in an amount of 0.001 to 10.0% by weight, preferably 0.05 to 2.0% by weight relative to the total weight of the cosmetic, Ursolic acid is 0.01 to 5.0% by weight relative to the total weight of the cosmetic, Preferably it is contained in the amount of 0.1-2.0 weight%.

Hereinafter, a test example will be described in detail the configuration and effects of the present invention, but the present invention is not intended to be limited to these test examples.

For the test examples, according to the present invention as shown in Table 1, a composition containing ursolic acid together with retinol (example) and a composition containing only retinol (comparative example) were prepared.

The raw materials of phase A and phase B of Table 1 were uniformly mixed, heated to 75 ° C., and then emulsified in two phases, cooled to 45 ° C., and then stabilized retinol (liposphere), ursolic acid, and The fragrance and the preservative were added and mixed in order to obtain the final product.

Table 1.

Examples and Comparative Examples

Unit: weight% ingredient Example Comparative Example Delta-tocopherol 0.2 0.2 Lipospeare 10.0 10.0 Usolelic acid 0.5 - A Cetostearyl alcohol 2.0 2.0 Glyceryl Stearate 1.5 1.5 Microcrystallin 0.7 0.7 Squalane 5.0 5.0 Liquid paraffin 3.0 3.0 Trioctanoine 5.0 5.0 Polysorbate 60 1.2 1.2 Sorbitan stearate 0.5 0.5 Cyclomethicone 3.0 3.0 Tocopheryl Acetate 0.2 0.2 BHT 0.05 0.05 B Purified water Remaining amount Remaining amount Concentrated glycerin 4.0 4.0 1,3-butylene glycol 2.0 2.0 Xanthan Gum 0.1 0.1 EDTA-2Na 0.05 0.05 Incense, preservative Quantity Quantity system 100 100

Retinol is contained in the liposperia of Table 1, which is added to the B phase and then emulsified as a final product.

Table 2.

Liposperia Ingredients

Unit: weight% ingredient Lipospia A Hydrogenated lecithin retinol tocopherol trioctanoin 5.03.05.015.0 B Alcohol solution (50% by weight) Remaining amount system 100

[Test Example 1] Wrinkle improvement effect

The skin wrinkle improvement effect on the cosmetics containing the retinol and ursolic acid of the present invention was measured.

Twenty women over 30 years old (average age 33.5 years) were divided into two groups (A and B), and the examples for group A and the comparative examples for group B were formulated according to Table 1 above. After 8 weeks and 24 weeks of application on the area of 2X2 cm2 of the upper arm (2 times / day, 0.2g / time), a replica of the skin wrinkles is floated using a transparent silicone solution. Skin wrinkle change was measured using VISIOMETER SV400, C + K Electronics GmbH. Three-dimensional analysis of the image of the replica with a CCD camera, wrinkle improvement by the average wrinkle roughness (R _z ) of the formula obtained by dividing the sum of roughness (R _m : m is an integer of 1 or more) of each wrinkle by the number of wrinkles The effect was analyzed. The test results are shown in Tables 3 and 4 below.

Table 3.

Skin wrinkle improvement effect (8 weeks)

Average wrinkle roughness (R _z, ㎛) Example Comparative Example T0 T8 ΔR _z T0 T8 ΔR _z Subject 1 114 95 -19 107 92 -15 Subject 2 133 101 -32 118 103 -15 Subject 3 138 82 -56 126 92 -34 Subject 4 124 103 -21 120 100 -20 Subject 5 120 88 -32 135 108 -27 Subject 6 115 84 -31 127 109 -18 Subject 7 142 113 -29 133 130 -3 Subject 8 128 87 -41 119 111 -8 Subject 9 135 115 -20 120 108 -12 Subject 10 105 74 -31 99 67 -32 Average -31.2 -18.4

Table 4.

Skin wrinkle improvement (24 weeks)

Average wrinkle roughness (R _z, ㎛) Example Comparative Example T0 T24 ΔR _z T0 T24 ΔR _z Subject 1 120 60 -60 121 92 -29 Subject 2 115 35 -80 115 56 -59 Subject 3 125 20 -105 141 81 -60 Subject 4 135 46 -89 123 92 -31 Subject 5 120 47 -73 107 78 -29 Subject 6 130 30 -100 139 91 -48 Subject 7 115 40 -75 115 69 -46 Subject 8 127 40 -87 102 55 -47 Subject 9 125 28 -97 143 102 -41 Subject 10 143 35 -108 133 85 -48 Average -85.4 -43.8

As a result, after 8 weeks, the examples containing retinol and ursolic acid were lowered by 31.2 μm (p <0.05), and the wrinkles were improved more than about 69.6% compared to the comparative examples containing only ursolic acid. It became. Therefore, it can be seen from the above results that solic acid (Ursolic acid) very effectively enhances the wrinkle improvement effect of retinol.

In addition, looking at the skin wrinkle improvement effect (24 weeks) of Table 4, the embodiment of the present invention is 85.4㎛ lower (p <0.01) shows a very effective wrinkle improvement effect. On the other hand, the comparative example is 43.8 μm lower (p <0.05), but the wrinkle improvement effect, but it can be seen that the wrinkle improvement effect is similar to the results of the skin wrinkle improvement effect (8 weeks) of the Example of Table 3. This generally shows that the cosmetics currently used for wrinkle improvement may take a long time of more than 24 weeks to show a visible effect, whereas the ursolic acid-containing cosmetic composition of the present invention can see a visible effect in a very short time.

Test Example 2 Clinical Effect of Skin Wrinkle Improvement

The clinical effects of skin wrinkle improvement on the cosmetics containing the retinol and ursolic acid of the present invention were measured.

Twenty women over 30 years old (mean age 33.5 years old) were divided into two groups. Examples were prepared in Group A and Comparative Examples in Group B, respectively. After application, the degree of improvement of skin wrinkle (ΔW) was measured by classifying the objective evaluation of the skilled person and the subjective evaluation of the subject into the following six grades. The results are shown in Tables 5 and 6 below.

Skin wrinkle improvement evaluation criteria:

-3: extremely badly -2: worsening -1: slightly worsening

0: no change 1: slightly improved 2: improved 3: highly improved

Table 5.

Clinical Effects of Skin Wrinkle Improvement (Objective Evaluation by Skilled Workers)

Skin wrinkle improvement (△ W) Example Comparative Example T0 T12 T0 T12 Subject 1 0 3 0 3 Subject 2 0 3 0 2 Subject 3 0 3 0 2 Subject 4 0 2 0 2 Subject 5 0 3 0 2 Subject 6 0 3 0 One Subject 7 0 3 0 2 Subject 8 0 3 0 2 Subject 9 0 2 0 One Subject 10 0 2 0 2 △ W (T12-T0) 2.7 1.9

Table 6.

Clinical effect of skin wrinkle improvement (subjective evaluation of subject)

Skin wrinkle improvement (△ W) Example Comparative Example T0 T12 T0 T12 Subject 1 0 3 0 One Subject 2 0 3 0 3 Subject 3 0 3 0 3 Subject 4 0 3 0 One Subject 5 0 3 0 2 Subject 6 0 2 0 One Subject 7 0 3 0 2 Subject 8 0 3 0 3 Subject 9 0 3 0 3 Subject 10 0 2 0 One △ W (T12-T0) 2.8 2.0

In the case of the clinical trial results, the objective evaluation of the skilled person and the subjective evaluation of the subject were 2.7 and 2.8, respectively, indicating that the wrinkle improvement effect was very excellent. This is a 42.1% and 40% increase in the objective evaluation and the subjective evaluation of the subjects, respectively, compared to the comparative example containing only retinol, and it can be seen that ursolic acid greatly enhances the wrinkle improvement effect of retinol. .

Test Example 3 Clinical Effect of Skin Elasticity Improvement

The clinical effect of improving skin elasticity on the cosmetics containing the retinol and ursolic acid of the present invention was measured.

20 healthy women (mean age 33.5 years) were formulated according to the Examples and Comparative Examples according to Table 1 above, and applied to the Examples on the left side and the Comparative Example on the right for 12 weeks, the skin elasticity Skin elasticity was measured using a measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany). The test results are described in Table 7 below as the ΔR8 value of the Cutometer SEM 575, where the R8 value represents the nature of the skin viscoelasticity.

Table 7.

Skin elasticity

Test Product Skin elasticity effect Example 0.38 Comparative Example 0.12

As can be seen from the results of Table 7, the skin elasticity of the example containing ursolic acid was increased by 217% compared to the comparative example. This suggests that ursolic acid has a very effective synergistic effect in promoting retinol collagen synthesis to promote skin elasticity. It can be seen that the bundle structure of collagen is normally made by the collagen synthesis ability of ursolic acid, and thus the skin elasticity is rapidly increased by promoting the elasticity of the skin.

Test Example 4 Moisturizing Effect

The moisturizing effect on the cosmetics containing the retinol and ursolic acid of the present invention was measured.

Example 25 and comparative examples of 20 healthy women (average age 33.5 years) indoors without air flow at 25 ℃, the Examples and Comparative Examples were formulated in accordance with Table 1, respectively, 3 to the upper arm After 6 weeks of application, the transdermal moisture loss, that is, the TEWL (Transepidermal Water Loss) value, was measured using TEWAMETER TM210 (C + K electronic GmbH. Moisturizing effect was measured by quantifying the moisture content of the skin from 0 to 150 with the change of the electrical conductivity according to the epidermal moisture content using a PC (C + K electronic GmbH. Germany). The test results are shown in Table 8 below.

Table 8.

Skin moisturizing effect

Test Product △ TEWL Corneometer value Example 5.8 123 Comparative Example 2.8 101

As a result, it can be seen that the ΔTEWL value of the Example was 5.8 g / hm ² , and the percutaneous moisture loss amount was improved very effectively after 6 weeks compared to the comparative example.

In addition, in the Corneometer value measured the moisture content of the skin, the Example is increased by 21.8% compared to the Comparative Example it can be seen that the skin is very moist.

Test Example 5 Skin Safety Test

Skin safety test was performed on the cosmetics containing the retinol and ursolic acid of the present invention.

Thirty subjects (mean age 26.7 years, age distribution 18 years to 30 years) were divided into two groups (A, B), and the examples for group A and the comparative examples for group B, respectively. Formulated according to 1, using a Haye's Test Chamber to the skin patch test (Patch Test) was performed. Those with Psoriasis, Eczema, and other skin lesions or those who are pregnant, nursing or contraceptives, and antihistamines are excluded from this study.

The test site was wiped with 70% ethanol and dried, and the Examples were dropped into the A group and the Comparative Examples were dropped into the chamber of 15 µg each in the B group, and then fixed on the upper arm, which is the test site. The patch is applied for 24 hours, and after the patch is removed, the test site is marked with a marking pen, and the test site is observed after 24 hours, 48 hours, and 72 hours, respectively.

Determination was performed 24 hours, 48 hours, 72 hours after patch removal, and skin reaction was determined according to the regulations of the International Contact Dermatitis Research Group (ICDRG) shown in Table 9 below. The test results are shown in Table 10 below.

Table 9.

Criteria for international contact dermatitis

sign Criteria evaluation Mean score ± ++++++- Doubtful or slight reaction and erythemaErythema + IndurationErythema + Induration + VesicleErythema + Induration + Bullae Stimulus stimulus non stimulus 0 to 0.91.0 to 2.93.0 to 4.95.0 or more

Table 10.

Skin safety

Elapsed time Example Comparative Example 24 hours 0 0.5 48 hours 0 0.0 72 hours 0 0.0

As a result of skin safety test, the Example shows that the average irritation degree is 0, and it is a safe cosmetic without irritation on the skin, and the cream containing lipopia which stabilized the retinol of Comparative Example also showed weak irritation after 24 hours. It can be seen that the liposphere of the present invention very effectively alleviates the retinol irritation when it is recalled that there is no irritation so that retinol generally has irritation to the skin.

[Test Example 6] Skin irritation test (Stinging Potential Test)

The skin irritation test was carried out on the cosmetics containing the retinol and ursolic acid of the present invention.

For 20 subjects (average age 24 years, age 20-31 years), a sufficient amount of sweating was performed using a steam generator for 15 minutes, followed by an example on the left face and a comparative example on the right face. Rubbing strongly around. Stinging grades were evaluated as classified as intense stinging within 30 seconds, mild stinging within 2.5 minutes, moderate stinging within 5 minutes, and delayed stinging within 8 minutes after application. Those with Psoriasis, Eczema, or other skin lesions, or those who are pregnant, nursing or contraceptives, and antihistamines are excluded from this study.

After applying the sample (Example, Comparative Example) to the face, the skin reaction (itch, itching, soreness, redness, swelling, etc.) observed for 8 minutes, and the response score to the number of subjects (n) Stimulation was evaluated by obtaining the response rate (%). The degree of skin irritation according to the stimulation rate was determined according to Table 11 below and the results are shown in Table 12.

Table 11.

Skin irritation test criteria

Grade Response rate (%) Judgment One 0.00-0.75 Non-irritating 2 0.76-1.50 Unstimulated 3 1.51-2.50 Light stimulation 4 2.51-4.00 Heavy stimulation 5 4.01 or more Strong stimulation

Table 12.

Skin irritation test result

Example Comparative Example Response rate (%) 0.5 0.92 Judgment Non-irritating Unstimulated Grade One 2

As a result of skin safety test by skin irritation test, the Example was determined to be non-irritating with a response rate (%) of 0.5, and the comparative example containing only retinol showed slight irritation with a response rate (%) of 0.9. This is generally very low compared to the irritation of the cream containing retinol, it can be seen that the skin irritation caused by retinol is remarkably relieved by liposphere.

Test Example 7 Stability Test of Formulation

The stability test of the formulation for the cosmetic containing the retinol and ursolic acid of the present invention was carried out.

To test the stability of the cosmetics, the above examples and comparative examples were kept in an opaque glass container in a constant temperature bath at 45 ° C. for 12 weeks, and were also opaque in a completely shaded refrigerator kept at 4 ° C. After storing for 12 weeks in a glass container, the degree of separation and discoloration were measured. The results are shown in Table 13 below. At this time, the degree of product separation and discoloration were evaluated by classifying into the following six grades.

Product discoloration evaluation criteria:

0: no change 1: very little separation (discoloration)

2: Separate slightly (discolored) 3: Separate slightly (discolored)

4: severely separated (discolored) 5: extremely severely separated (discolored)

Table 13.

Separation and discoloration

Temperature Discoloration degree of test substance Example Comparative Example 45 ℃ 0.5 0.5 4 ℃ 0 0

As can be seen in Table 13, both Examples and Comparative Examples have a slight discoloration at 45 ℃ but this is a very stable formulation considering that the material is very sensitive to the retinol temperature that can appear in the general cream formulation Can be. This shows that retinol is very effectively stabilized by liposphere.

Hereinafter, based on the results of the above test examples, a cosmetic composition containing retinol and ursolic acid is presented. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1 Softening Cosmetic (Skin Lotion)

Ingredient Parts by weight Lipospeare 0.1 Usolelic acid 0.05 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2. Nutrients (Milk Lotion)

Ingredient Parts by weight Lipospeare 2.0 Usolelic acid 0.2 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocopheryl Acetate 3.0 Floating paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 Bietchiti 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3. Nutrition Cream

Ingredient Parts by weight Lipospeare 10.0 Usolelic acid 0.5 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Liquid paraffin 3.0 Cyclomethicone 3.0 Bietchiti 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Xanthan Gum 0.1 IDT-2N 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4 Massage Cream

Ingredient Parts by weight Lipospeare 0.1 Usolelic acid 0.05 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation Example 5 Pack

Ingredient Parts by weight Lipospeare 2.0 Usolelic acid 0.2 Propylene glycol 2.0 glycerin 4.0 Carboxyvinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Bietchiti 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

As described above, the cosmetic composition of the present invention contains ursolic acid, thereby improving clinical wrinkles, improving blemishes, freckles, and pigments such as blotch, enhancing skin elasticity, whitening effect, and moisturizing effect, while maintaining the efficacy of retinol as a cosmetic. It is possible to provide a cosmetic composition that overcomes the problems of weak efficacy and prolonged period of use required for visible clinical results.

In addition, the ursolic acid-containing cosmetic composition of the present invention was found to significantly improve the safety and stability as a cosmetic such as not causing skin irritation and no separation or discoloration phenomenon during storage.

Claims (3)

A cosmetic composition, characterized in that it contains ursolic acid together with retinol. The method of claim 1, Usolic acid is contained in an amount of 0.01 to 5.0% by weight based on the total weight of the cosmetic, cosmetic composition. The method of claim 1, Usolic acid is contained in an amount of 0.1 to 2.0% by weight based on the total weight of the cosmetic, cosmetic composition.