KR20010094557A - Medical Composition Comprising Effective Extract of Emphedra sinica Root for Treating Functional Enuresis - Google Patents

Abstract

PURPOSE: An agent for treating and reducing nocturnal enuresis containing Ephedrae Herba root extract as an effective component is provided, which has almost no side effects and high treating effects. CONSTITUTION: The titled agent contains Ephedrae Herba root extract as an effective component. For an example, 8 to 40g finely cut Ephedrae Herba root is added with water, heated for 100 to 200 min and filtered. In clinical testing on patients, it shows remarkable effects(77.6%) such as complete recovery or improvement in symptoms.

Description

Medical composition Comprising Effective Extract of Emphedra sinica Root for Treating Functional Enuresis}

The present invention relates to a treatment for enuresis with an ephedra muscle extract as an active ingredient, and more particularly, to a composition capable of treating and alleviating enuresis by taking an extract extracted from the root of ephedra.

Nocturnal enuresis is a term used to refer to a problem in the act of masking feces or urine. It is called an elimination disorder, one of which is called functional enuresis. If you only sleep at night, it is called nocturnal enuresis, and during the day it is called diurnal enuresis. Therefore, nocturnal enuresis is a form of enuresis. Nocturnal enuresis, which is intentional or unconscious, urinates repeatedly in bedding or clothing, diagnosed as nocturnal enuresis when this behavior occurs at a frequency of twice a week for at least three consecutive months, and is a social, academic (professional) or other important functional area. Causes clinically serious pain or disability. In addition, this behavior should not be solely due to the direct physiological effects of drugs such as the use of diuretics or general medical conditions (eg diabetes, spina bifida, convulsive disease).

Statistically, nocturnal enuresis occurs in 7% of boys and 3% of girls around 5 years of age. About 10% of 7-year-olds and 3% of 10-year-olds do not meet the criteria for nocturnal enuresis. There is a mistake in urine and about 1% of adults are known to have urination.

The causes of nocturnal enuresis are known to have family causes, bladder dysfunction and many other factors.

As a family cause, 75% of children with nocturnal enuresis are known to have a family tendency. If one parent has enuresis, about 40% of children have enuresis, and if both parents have enuresis, 70% have enuresis. In addition, as a functional disorder of the bladder, it is often anatomically normal but functionally has a small bladder. Children with nocturnal enuresis often urinate more than normal children and feel urinary even if the urine is slightly filled with the bladder.

In contrast, nocturnal enuresis, which occurs in immature people of the central nervous system, is reported to be associated with immaturity of the brain as a form of developmental disability. As a hormonal cause, studies have reported that the secretion of antidiuretic hormones associated with urine production during sleep is lower than in normal children.

Psychosocial stress can also lead to nocturnal enuresis, for example, psychological regression occurs when there is stress such as the birth of a younger brother, hospitalization due to illness, admission, parental divorce, death of a relative, moving, or transfer. Nocturnal enuresis can also occur when complaints or anger are suppressed.

In addition, as a natural factor, daytime enuresis occurs more often when a child is inadvertent to his or her physical cues. If you have a short concentration and are distracted by playing, you may urinate before arriving at the bathroom.

Nocturnal enuresis is very psychologically pressured in daily life, so it is often reluctant to go to a relative's house and go to school trips. As a result, they lose their self-confidence, have a negative attitude that they are not good enough, and they are socially depressed by their shameful mind. Family problems may be aggravated by urine problems, and may later lead to behavior problems.

Nocturnal enuresis most often improves over time, but sometimes it recurs, and in about 1% of the symptoms persist until adulthood is known.

For the treatment of nocturnal enuresis, it is not advisable to treat the bladder abnormally once, to disturb the child's daily activities due to urine problems, to develop psychological sequelae, and to treat the parents strictly and punitively. It is very important to induce voluntary participation.

Therefore, record urine screening exercises, limiting fluid intake at night, reducing dinner volume and avoiding spicy and salty foods. In addition, regular urination before going to sleep, to wake up in the night to urinate, but the exact time should be determined regularly. As a training method, allow the patient to drink a certain amount of water and then repeat the training to hold the urine for as long as possible.

Medication is used as an antidepressant, imipramine, which is effective, but it is pointed out that recurrence and side effects are great after discontinuing the medication. Desmopressin, an antidiuretic hormone, can be taken before bedtime or by spraying into the nose.

Behavioral psychotherapy and drug therapy for the treatment of nocturnal enuresis have been applied, but behavioral psychotherapy often fails due to the constant effort and patience of patients and families, and there are many concerns about recurrence and side effects of drug therapy. .

Accordingly, the present invention provides a drug for treating nocturnal enuresis, which has little side effects and a high therapeutic effect as a herbal medicine.

Such an object of the present invention can be achieved by a nocturnal enuretic therapeutic agent having the extract extracted with ephedra muscle with water as an active ingredient.

Ephedra is a perennial shrub herbaceous plant with Ephedra. Ephedra is usually cut before and after the green leaves, dried in the shade, and then sliced, roasted or steamed. The taste is spicy, bitter and hot.

Ephedra is a medicine that has been used for a long time in oriental medicine, eliminating the cold that occurs in the human body and activates the bronchus. Ephedra has ephedrine to constrict blood vessels and increase blood pressure slowly and continuously, which is good for asthma, and essential oils are compatible with sweating and have the effect of suppressing influenza. In addition, sweating, diuretic, blood pressure rise, because it is used for headaches, when the urgent pulse.

This ephedra using ephedra is a decoction of 9.0g of ephedra, add 1,100ml of water until it becomes 840ml, and then add 9.0g of almonds, 6.0g of cinnamon, and 3.0g of licorice, and add it again until it becomes 300ml. Filter the dry Take 100 ml of this solution three times a day. This may be used for colds, stuffy nose, nosebleeds, joint pain, muscle pain, and bronchial asthma.

In addition, the ephedra gachultang is evaporated ephemeral (麻黃 加 朮 湯) and put the ephedra 3.0g in 360ml of water until the 280ml is sweetened. Add 4.0g of baekchul, 3.5g of almonds, 2.0g of cinnamon, 2.0g of licorice and weigh it until it reaches 100ml and filter it for drinking. Drink it as a cup of hot water, and take it three times a day to treat rheumatism, arthritis, sinusitis, etc. It shows efficacy.

On the other hand, Ma line stone persimmon (麻 杏 草 石 甘 湯) is called the Ma line stone or the ephemeral persimmon gamchotang, gypsum is added instead of the base of the ephedra, it is known to be effective in acute bronchitis, pneumonia and asthma attacks. .

As described above, the medicinal herb used as the main material of ephedra is to use the ephedra branch, but the pharmacological action of the ephedra branch and its root is reported to be different. That is, since the ephedra branches exhibit sweating effects, it is reported that fever and chills do not cause sweating, the head is sore, the nose is hot, and the bone nodes are sore and painful. In this way, while the branch of ephedra is mainly sweating, while the root of ephedra has a slowing effect on the contrary, it is reported that the body shows weakness when sweating cold.

The composition of the present invention, unlike the conventional ephedra-related decoction, using the root, the present inventors found that it is effective in nocturnal enuresis by orally administering the extract extracted by putting the ephedra muscle in water and iron.

According to the present invention, the ephedra muscle is finely chopped, and 8 g to 40 g are put in 600 to 1,000 ml of water and extracted by heating for 100 to 200 minutes. By filtering this and removing solid content, the composition which uses the extract which extracted ephedra muscle in accordance with this invention as an active ingredient is obtained.

Experimental Example

Applicant has clinically administered the nocturnal enuresis treatment of the present invention to 67 patients with nocturnal enuresis from August 2008 to February 2000, 1999, at Pediatrics, College of Oriental Medicine, Kyung Hee University. Administration of the therapeutic agent of the present invention was allowed to drink 120-150ml once at 6 pm once a day and the prognosis was observed.

Two weeks after the start of administration, 25 patients were cured at the fourth week of enuresis who had cured enuresis. At week 4, 27 patients significantly reduced the frequency of urination. There was no change in symptoms in 15 patients.

As can be seen from the above description, the nocturnal enuresis treatment agent of the present invention may be provided in the form of a decoction, which has little side effects and can be orally administered, and exhibits a remarkable therapeutic effect on nocturnal enuresis. Because the cause of nocturnal enuresis can be caused by genetic and organic factors as well as physical disorders, the clinical trials according to the present invention did not show a therapeutic effect in all patients, but in 77.6% of patients the improvement of cure or marked symptoms was not achieved. It showed a very significant effect.

Claims (1)

A treatment for nocturnal enuresis, using the extract of ephedra muscle as an active ingredient.