KR20010087412A - 사르코시스티스, 네오스포라 및 톡소플라즈마에 의한 질병치료용 트리아진온 화합물 - Google Patents
사르코시스티스, 네오스포라 및 톡소플라즈마에 의한 질병치료용 트리아진온 화합물 Download PDFInfo
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- KR20010087412A KR20010087412A KR1020017007027A KR20017007027A KR20010087412A KR 20010087412 A KR20010087412 A KR 20010087412A KR 1020017007027 A KR1020017007027 A KR 1020017007027A KR 20017007027 A KR20017007027 A KR 20017007027A KR 20010087412 A KR20010087412 A KR 20010087412A
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- South Korea
- Prior art keywords
- compound
- triazineone
- toxoplasma
- neospora
- administered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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Abstract
Description
성분 | 이론적인 양 | 실질적인 양(%w/w) |
미소화된 폰아주릴프로필렌 글리콜카보폴 974P메틸파라벤, NF프로필파라벤, NF수산화나트륨, NF정제수 | 22.5 ㎏30.0 ㎏0.750 ㎏0.210 ㎏0.030 ㎏0.150 ㎏96.365 ㎏ | 15.020.00.50.140.020.1064.24 |
Claims (25)
- 트리아진온 화합물로 치료시 감수성을 나타내는 기생충성 신경학적 (neurologic) 또는 발육부전성(abortigenic) 질환을 앓고 있는 동물에게 약제학적으로 유효한 양의 트리아진온 화합물을 투여함을 특징으로 하여, 상기 질환을 앓고 있는 동물을 치료적으로 치료하는 방법으로서, 단 질환이 사르코시스티스 뉴로나(Sarcocystis neurona)인 경우, 화합물이 디클라주릴 또는 톨트라주릴인 경우는 제외되는 방법.
- 제 1 항에 있어서, 기생충성 질환이 콕시디아(Coccidia)에 의한 것인 방법.
- 제 2 항에 있어서, 콕시디아가 사르코시스티다에(Sarcocystidae) 패밀리의 멤버인 방법.
- 제 3 항에 있어서, 사르코시스티다에 패밀리의 멤버가 사르코시스티스 (Sarcocystis), 네오스포라(Neospora) 및 톡소플라즈마(Toxoplasma)로 구성된 그룹중에서 선택되는 방법.
- 제 4 항에 있어서, 사르코시스티스가 사르코시스티스 종(Sarcocystis spp.)으로 구성된 그룹중에서 선택되고, 네오스포라가 네오스포라 종(Neospora spp.)으로 구성된 그룹중에서 선택되며, 톡소플라즈마가 톡소플라즈마 종(Toxoplasma spp.)으로 구성된 그룹중에서 선택되는 방법.
- 제 5 항에 있어서, 사르코시스티스 종이 사르코시스티스 뉴로나(Sarcocystis neurona)이고, 네오스포라 종이 네오스포라 카니눔(Neospora caninum) 또는 네오스포라 휴게시(Neospora hugesi)이며, 톡소플라즈마 종이 톡소플라즈마 곤디 (Toxoplasma gondii)인 방법.
- 제 4 항에 있어서, 사르코시스티스가 말의 원생동물성 뇌척수염(Equine Protozoal Myeloncephylitis)을 유발하는 사르코시스티스 뉴로나인 방법.
- 제 4 항에 있어서, 네오스포라가 소 또는 개 네오스포로시스(Neosporosis)를 유발하는 네오스포라 카니눔인 방법.
- 제 4 항에 있어서, 톡소플라즈마가 톡소플라즈마 곤디(Toxoplasma gondii)인 방법.
- 트리아진온 화합물로 치료시 감수성을 나타내는 신경학적 또는 발육부전성 질환의 유발 요인인 기생충으로 감염된 동물에게 메타방어적으로 (metaphylactically) 유효한 섭생량의 트리아진온 화합물을 투여함을 특징으로 하여, 상기 질환의 유발 요인인 기생충으로 감염된 동물을 메타방어적으로 치료하는 방법.
- 제 1 항 또는 제 10 항에 있어서, 트리아진온 화합물이 톨트라주릴, 폰아주릴 및 디클라주릴로 구성된 그룹중에서 선택되는 방법.
- 제 1 항 또는 제 10 항에 있어서, 트리아진온 화합물이 폰아주릴인 방법.
- 제 1 항 또는 제 10 항에 있어서, 트리아진온 화합물이 2 이상의 반복 투여량으로 투여되는 방법.
- 제 13 항에 있어서, 반복 투여량이 1.0 내지 100 ㎎/㎏의 양으로 투여되는 방법.
- 제 10 항에 있어서, 트리아진온 화합물이 동물에게서 보호적인 면역성이 전개될 때까지 투여되는 방법.
- 제 1 항 또는 제 10 항에 있어서, 트리아진온이 2.5 내지 10 ㎎/㎏의 양으로 투여되는 방법.
- 제 16 항에 있어서, 트리아진온이 톨트라주릴 또는 폰아주릴인 방법.
- 제 1 항에 있어서, 트리아진온 화합물이 10 ㎎/㎏을 초과하는 단일 고 용량으로 투여되는 방법.
- 제 8 항에 있어서, 트리아진온 화합물이 면역학적 보호가 확립될 때까지 반복적인 정기적 용량으로 투여되는 방법.
- 제 1 항에 있어서, 트리아진온 화합물이 28 일 기간동안 매일 2.5 내지 10 ㎎/㎏의 섭생량으로 투여되는 방법.
- (a) 트리아진온 화합물에 감수성을 나타내는 질환에 걸린 동물을 치료하기에 약제학적으로 유효한 양의 트리아진온 화합물, (b) 담체, 및 임의로 (c) 보조제를 함유하는 치료제 조성물.
- 제 21 항에 있어서, 페이스트 형태인 조성물.
- 말의 원생동물성 뇌척수염(EPM)을 앓고 있는 것으로 예상되는 말에게 치료적으로 유효한 양의 하나이상의 트리아진디온을 투여함을 특징으로 하여 EPM을 치료하는 방법.
- 제 23 항에 있어서, 트리아진디온이 디클라주릴인 방법.
- 제 23 항에 있어서, 말이 호올스(horse)인 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/218,713 US6194408B1 (en) | 1998-12-22 | 1998-12-22 | Triazineone compounds for treating diseases due to Sarcocystis, Neospora and Toxoplasma |
US09/218,713 | 1998-12-22 |
Publications (2)
Publication Number | Publication Date |
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KR20010087412A true KR20010087412A (ko) | 2001-09-15 |
KR100661102B1 KR100661102B1 (ko) | 2006-12-26 |
Family
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Application Number | Title | Priority Date | Filing Date |
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KR1020017007027A KR100661102B1 (ko) | 1998-12-22 | 1999-12-18 | 사르코시스티스, 네오스포라 및 톡소플라즈마에 의한 질병치료용 트리아진온 화합물 |
Country Status (17)
Country | Link |
---|---|
US (1) | US6194408B1 (ko) |
EP (1) | EP1140102B1 (ko) |
JP (1) | JP4806121B2 (ko) |
KR (1) | KR100661102B1 (ko) |
CN (1) | CN1188128C (ko) |
AT (1) | ATE270891T1 (ko) |
AU (1) | AU770108B2 (ko) |
BR (1) | BR9916432A (ko) |
CA (1) | CA2356151C (ko) |
DE (1) | DE69918716T2 (ko) |
ES (1) | ES2226492T3 (ko) |
HK (1) | HK1043315A1 (ko) |
HU (1) | HU228994B1 (ko) |
NZ (1) | NZ512478A (ko) |
PT (1) | PT1140102E (ko) |
WO (1) | WO2000037064A2 (ko) |
ZA (1) | ZA200104205B (ko) |
Cited By (2)
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KR101148098B1 (ko) * | 2010-04-30 | 2012-05-22 | 한국화학연구원 | 1-[4-(4-니트로-페녹시)-페닐]-프로판-1-온을 유효성분으로 함유하는 톡소포자충 및 콕시디움에 기인한 질환의 예방 및 치료용 조성물 |
KR101242535B1 (ko) * | 2010-10-05 | 2013-03-12 | 주식회사이-글벳 | 콕시듐 치료 및 예방을 위한 조성물의 제조방법 |
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US6469987B1 (en) | 1998-01-13 | 2002-10-22 | Enterasys Networks, Inc. | Virtual local area network with trunk stations |
EP1119255A4 (en) * | 1998-10-08 | 2009-04-15 | New Ace Res Company | NEW COMPOSITIONS AND METHOD FOR THE PREVENTION AND TREATMENT OF PROTOCOL DISEASES |
DE19958388A1 (de) * | 1999-12-03 | 2001-06-07 | Bayer Ag | Triazinonverbindungen zur Behandlung von durch den Befall mit parasitischen Protozoen bedingten Krankheiten |
WO2001080885A2 (en) * | 2000-04-25 | 2001-11-01 | Wyeth | Equine protozoal myeloencephalitis vaccine |
DE10040110A1 (de) * | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfoxiden zur Bekämpfung von Coccidiosen |
US6562007B1 (en) * | 2000-09-28 | 2003-05-13 | Bayer Healthcare Llc | Adjustable dosage syringe |
US20060240049A1 (en) * | 2003-01-16 | 2006-10-26 | Bart De Spiegeleer | Anti-protozoal compositions comprising diclazuril |
DE102007025908A1 (de) * | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
DE102009012423A1 (de) | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
CN102772363B (zh) * | 2012-08-22 | 2013-10-09 | 青岛康地恩药业股份有限公司 | 一种含泊那珠利的溶液剂及其制备方法 |
CA3033065A1 (en) | 2016-08-11 | 2018-02-15 | Adamis Pharmaceuticals Corporation | Drug compositions |
EP3720844A4 (en) | 2017-12-08 | 2021-08-11 | Adamis Pharmaceuticals Corporation | MEDICINAL COMPOSITIONS |
US20220000876A1 (en) * | 2018-11-02 | 2022-01-06 | Adamis Pharmaceuticals Corporation | Drug compositions |
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DE2313721A1 (de) * | 1973-03-20 | 1974-10-03 | Bayer Ag | Neue 1-phenylsubstituierte 1,3,5triazine, verfahren zu ihrer herstellung, sowie ihre verwendung als arzneimittel |
AU616916B2 (en) | 1987-11-20 | 1991-11-14 | Kissei Pharmaceutical Co. Ltd. | 4h-quinolizin-4-one compounds exhibiting therapeutic activities |
DE3826058A1 (de) | 1988-07-30 | 1990-02-08 | Bayer Ag | Mittel gegen fischparasiten |
US4933341A (en) * | 1988-10-08 | 1990-06-12 | Bayer Aktiengesellschaft | Substituted 1,3,5-triazinetriones, for use against parasitic protozoa |
US5196562A (en) | 1988-10-08 | 1993-03-23 | Bayer Aktiengesellschaft | Substituted 1,3,5-triazinetriones, for use against parasitic protozoa |
EP0377903A3 (de) | 1989-01-09 | 1991-07-17 | Bayer Ag | Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
CN1044905A (zh) | 1989-02-16 | 1990-08-29 | 赫彻斯特股份公司 | 鱼和昆虫寄生虫对抗剂 |
DE4030042A1 (de) | 1990-05-17 | 1991-11-21 | Bayer Ag | Verwendung von substituierten 1,2,4-triazindionen |
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WO1998043644A1 (en) * | 1997-03-31 | 1998-10-08 | David Granstrom | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
US5883095A (en) * | 1997-08-07 | 1999-03-16 | University Of Kentucky Research Foundation | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
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-
1998
- 1998-12-22 US US09/218,713 patent/US6194408B1/en not_active Expired - Fee Related
-
1999
- 1999-12-18 NZ NZ512478A patent/NZ512478A/en not_active IP Right Cessation
- 1999-12-18 AT AT99967434T patent/ATE270891T1/de active
- 1999-12-18 PT PT99967434T patent/PT1140102E/pt unknown
- 1999-12-18 WO PCT/US1999/030293 patent/WO2000037064A2/en active IP Right Grant
- 1999-12-18 DE DE69918716T patent/DE69918716T2/de not_active Expired - Lifetime
- 1999-12-18 JP JP2000589175A patent/JP4806121B2/ja not_active Expired - Lifetime
- 1999-12-18 CA CA002356151A patent/CA2356151C/en not_active Expired - Lifetime
- 1999-12-18 EP EP99967434A patent/EP1140102B1/en not_active Expired - Lifetime
- 1999-12-18 KR KR1020017007027A patent/KR100661102B1/ko active IP Right Grant
- 1999-12-18 HU HU0104710A patent/HU228994B1/hu unknown
- 1999-12-18 CN CNB998149683A patent/CN1188128C/zh not_active Expired - Lifetime
- 1999-12-18 AU AU23709/00A patent/AU770108B2/en not_active Expired
- 1999-12-18 ES ES99967434T patent/ES2226492T3/es not_active Expired - Lifetime
- 1999-12-18 BR BR9916432-9A patent/BR9916432A/pt not_active Application Discontinuation
-
2001
- 2001-05-23 ZA ZA200104205A patent/ZA200104205B/en unknown
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101148098B1 (ko) * | 2010-04-30 | 2012-05-22 | 한국화학연구원 | 1-[4-(4-니트로-페녹시)-페닐]-프로판-1-온을 유효성분으로 함유하는 톡소포자충 및 콕시디움에 기인한 질환의 예방 및 치료용 조성물 |
KR101242535B1 (ko) * | 2010-10-05 | 2013-03-12 | 주식회사이-글벳 | 콕시듐 치료 및 예방을 위한 조성물의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
ES2226492T3 (es) | 2005-03-16 |
EP1140102A2 (en) | 2001-10-10 |
CN1188128C (zh) | 2005-02-09 |
HUP0104710A2 (hu) | 2002-04-29 |
EP1140102B1 (en) | 2004-07-14 |
BR9916432A (pt) | 2001-09-04 |
AU770108B2 (en) | 2004-02-12 |
JP4806121B2 (ja) | 2011-11-02 |
KR100661102B1 (ko) | 2006-12-26 |
CN1331594A (zh) | 2002-01-16 |
HK1043315A1 (en) | 2002-09-13 |
WO2000037064A3 (en) | 2000-10-26 |
HUP0104710A3 (en) | 2003-10-28 |
DE69918716D1 (de) | 2004-08-19 |
ATE270891T1 (de) | 2004-07-15 |
AU2370900A (en) | 2000-07-12 |
WO2000037064A2 (en) | 2000-06-29 |
NZ512478A (en) | 2003-07-25 |
CA2356151C (en) | 2009-02-24 |
ZA200104205B (en) | 2002-05-22 |
PT1140102E (pt) | 2004-10-29 |
JP2002532545A (ja) | 2002-10-02 |
US6194408B1 (en) | 2001-02-27 |
CA2356151A1 (en) | 2000-06-29 |
DE69918716T2 (de) | 2005-08-04 |
HU228994B1 (en) | 2013-07-29 |
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