KR20010067653A - Curing agent for allergic rhinitis and asthma, and the manufacturing method thereof - Google Patents

Curing agent for allergic rhinitis and asthma, and the manufacturing method thereof Download PDF

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KR20010067653A
KR20010067653A KR1020010010723A KR20010010723A KR20010067653A KR 20010067653 A KR20010067653 A KR 20010067653A KR 1020010010723 A KR1020010010723 A KR 1020010010723A KR 20010010723 A KR20010010723 A KR 20010010723A KR 20010067653 A KR20010067653 A KR 20010067653A
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South Korea
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asthma
allergic rhinitis
weight
extract
ephedra
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KR1020010010723A
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Korean (ko)
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김찬호
류희영
신민교
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김찬호
신민교
류희영
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Publication of KR20010067653A publication Critical patent/KR20010067653A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

PURPOSE: A drug for allergic rhinitis and asthma containing medicinal herb as an active ingredient is provided, which shows excellent effect on treating allergic rhinitis and asthma by softening the mucus of the bronchial tubes and inhibiting hypersensitive reaction of the respiratory system. CONSTITUTION: The drug for allergic rhinitis and asthma is manufactured by following processes of: preparing 25wt.% of Pinelliae Rhizoma, 20wt.% of Asiasari Radix, 10wt.% of Schizandrae Fructus, 10wt.% of Zingiberis Rhizoma, 10wt.% of Cinnamomi Ramulus, 10wt.% of Ephedrae Herba, 10wt.% of Paeoniae Radix, and 5wt.% of honey-fried Glycyrrhizae Radix, and mixing the medicinal herbs; adding water, and heating for 3hrs at 70-90deg.C; removing the scum floating on the mixture, and filtering to get the extract. The medicinal herb extract can be used as it is, or drug form such as powder, granule, tablet, capsule, and syrup.

Description

알레르기성 비염 및 천식 치료제와 그 제조방법{Curing agent for allergic rhinitis and asthma, and the manufacturing method thereof}Cure agent for allergic rhinitis and asthma, and the manufacturing method

본 발명은 알레르기성 비염 및 천식 치료제와 그 제조방법에 관한 것으로, 보다 상세하게는 세신, 반하, 오미자, 건강, 계지, 마황, 백작약, 자감초 등의 생약성분을 주재료로 하여 알레르기성 비염이나 천식을 치료할 수 있는 알레르기성 비염 및 천식 치료제와 그 제조방법에 관한 것이다.The present invention relates to a therapeutic agent for allergic rhinitis and asthma, and to a method for manufacturing the same. More specifically, allergic rhinitis and asthma are mainly composed of herbal medicines such as sessin, hwangja, Schisandra chinensis, health, gyeji, ephedra, earl pear, and persimmon. It relates to a treatment for allergic rhinitis and asthma that can treat the and a method of manufacturing the same.

일반적으로 알레르기성 비염은 코 점막이 특정물질에 대하여 과민반응을 나타내는 것으로 연속적인 재채기 발작, 계속 흘러내리는 맑은 콧물(수양성 비루), 코막힘(비폐색) 등이 특징적인 증상인 알레르기성 질환을 말한다. 그 외에도, 눈이나 인후두의 가려움증, 냄새 감지능력의 감퇴, 두통, 눈부심, 과도한 눈물, 피로 등의 증상이 유발되기도 한다. 이는 소아 때부터 발병하는 경우가 흔하며, 잘 치료하지 않아 오래되면, 코는 항상 막혀있게 되고 만성 부비동염(축농증), 비용종(물혹), 중이염 등을 유발하기도 한다. 또한, 코로 숨쉬기가 어려워 입으로 숨을 쉬게 되어 얼굴 발육이 위 아래로 길쭉한 기형이 되기 쉽고 치아 부정교합 등을 일으키기도 한다.In general, allergic rhinitis is an allergic disease in which the nasal mucosa is hypersensitive to certain substances and is characterized by continuous sneezing attacks, clear runny nose (aqueous nasal discharge), and nasal congestion (nasal obstruction). . In addition, it may cause symptoms such as itching of the eyes or throat, loss of smell detection, headache, glare, excessive tears, and fatigue. It often occurs from childhood, and if not treated well, the nose is always clogged and can cause chronic sinusitis (sinusitis), nasal polyps (water bumps), and otitis media. In addition, it is difficult to breathe through the nose to breathe in the mouth, the development of the face is prone to elongated deformity up and down, and also causes tooth malocclusion.

그리고, 천식은 숨 쉴 때 들어오는 여러 가지 자극 물질에 대한 기관지의 과잉반응으로, 기관지를 비롯한 기도점막에 염증이 생겨 부어오르며 기관지가 좁아져서 천명(쌕쌕거리는 호흡음)을 동반한 기침과 호흡곤란이 발작적으로 나타나는 질환으로, 일단 호전이 되면 대부분의 경우 거의 정상 상태로 회복이 되기는 하나 반복적으로 자주 재발하는 특징을 가진 호흡기질환이다. 이는 원인 항원을 밝힐 수 없는 내인성 천식과 원인 항원이 밝혀진 외인성 천식(혹은 알레르기성 천식)으로 대별되고, 그 이외에도 운동뒤에 생기는 유발성 천식, 아스피린이나 진통제를 먹고 나서 악화되는 아스피린 유발성 천식, 반응성 염료나 송진가루 등 특정물질에 오래 노출되어 생기는 직업성 천식 등이 포함되기도 하며, 우리나라 환자의 대부분(약 80%)은 내인성 천식과 외인성 천식을 모두 겸하는 환자이다.In addition, asthma is a bronchial overreaction to various irritants that come in when you breathe, inflammation and swelling in the airway mucosa, including the bronchus, and narrowing the bronchus, causing coughing and dyspnea with wheezing. It is a seizure disorder that is respiratory disease that is characterized by recurring frequent recurrences, although in most cases, it usually returns to a normal state once it improves. These are classified into endogenous asthma, which can not identify the causative antigen, and exogenous asthma (or allergic asthma), which are identified as causative antigens.In addition, induced asthma after exercise, aspirin-induced asthma and reactive dyes that worsen after eating aspirin or analgesics Occasional occupational asthma caused by long exposure to certain substances, such as rosin powder, may be included. Most of Korean patients (about 80%) are both endogenous and exogenous asthma.

이러한 알레르기성 비염이나 천식은 현대의학에서도 그 치료가 어려운 난치병으로 알려져 있는바, 알레르기성 비염의 일반적인 치료로서 알레르기를 일으키는 물질(알레르겐)에 노출을 피하는 회피요법, 약물요법, 면역요법이나 수술치료 등이 있으나 실제 완전한 치료란 어려운 실정이었으며, 천식의 일반적인 치료로서 약물요법, 체력단련요법, 환경요법(회피요법), 면역요법 등을 병용하고 있으나 증상이 일시적으로 호전되었다가도 자꾸 재발하는 등 알레르기성 비염과 마찬가지로 완전한 치료가 어려운 실정이었다.Allergic rhinitis and asthma are known as incurable diseases that are difficult to treat in modern medicine. As a general treatment of allergic rhinitis, avoidance therapy, drug therapy, immunotherapy or surgical treatment to avoid exposure to allergens (allergens) However, the complete treatment was difficult, and as a general treatment of asthma, drug therapy, physical therapy, environmental therapy (evacuation therapy), immunotherapy, etc. are used in combination, but symptoms improve temporarily, but allergic rhinitis Likewise, complete treatment was difficult.

특히, 실내온도가 높고 저습한 현대주택에서 생활하는 경우 기관지가 확장되고 호흡기의 점액이 부족한 상태를 유발하여 알레르기성 비염이나 천식의 치료를 더욱 어렵게 하고 있다.In particular, when living in a modern house with high indoor temperature and low humidity, the bronchus is enlarged and the mucus of the respiratory tract is insufficient, thereby making it more difficult to treat allergic rhinitis or asthma.

또한, 알레르기성 비염이나 천식의 치료를 위하여 현대의학에서 주로 사용하고 있는 화학물질은 그 독성이 심하여 소화장애, 어지러움증 및 속쓰림 등의 부작용을 유발시키는 것이었고, 게다가 장기적으로 복용할 경우 내성을 생기게 하여 알레르기성 비염이나 천식을 만성화시키는 문제점을 갖는 것이었다.In addition, the chemicals commonly used in modern medicine for the treatment of allergic rhinitis or asthma are severely toxic and cause side effects such as digestive disorders, dizziness and heartburn. Has had the problem of chronicizing allergic rhinitis or asthma.

최근에 제약회사들이 생약성분의 의약에 대하여 많은 관심을 기울이는 것도 이러한 화학약품이 주가 되는 치료제의 부작용에 기인한 것이라고 할 수 있다.Recently, pharmaceutical companies have been paying much attention to medicines of herbal ingredients due to the side effects of these chemicals.

그러나, 현재까지도 생약성분의 의약을 이용하여 알레르기성 비염이나 천식을 치료하는 구체적인 방법은 알려져 있지 않고, 다만 그러한 알레르기성 비염이나 천식에 효과가 있을 것으로 추측되는 몇 가지 생약성분을 필요에 따라 적당량씩 조제하여 알레르기성 비염이나 천식을 완화시키는 것이 고작이었다.However, up to now, no specific method for treating allergic rhinitis or asthma using herbal medicines is known, but some herbal ingredients that are supposed to be effective for such allergic rhinitis or asthma are needed as needed. It was only to reduce allergic rhinitis and asthma.

본 발명은 상기와 같은 종래의 문제점을 해소하기 위하여 발명된 것으로, 그 목적은 세신, 반하, 오미자, 건강, 계지, 마황, 백작약, 자감초 등으로 이루어져 기관지의 점액을 부드럽게 하면서 호흡기의 과민반응을 억제시켜줌으로써 알레르기성 비염이나 천식을 치료하는데 효과가 있는 알레르기성 비염 및 천식 치료제를 제공함에 있다.The present invention has been invented to solve the conventional problems as described above, the object is made of sessin, half, Schisandra chinensis, health, gyeji, ephedra, earl, Jacokcho, etc., to soften the mucus of the bronchus while hypersensitivity reaction of the respiratory tract Inhibiting allergic rhinitis and asthma is effective in treating allergic rhinitis and asthma.

본 발명의 다른 목적은, 상기한 생약성분을 이용함으로써 장기간 계속 사용하더라도 부작용이 없는 알레르기성 비염 및 천식 치료제를 제공함에 있다.Another object of the present invention is to provide a therapeutic agent for allergic rhinitis and asthma, which does not have side effects even if it continues to be used for a long time by using the herbal ingredient described above.

본 발명은 아래의 공정들에 의하여 알레르기성 비염이나 천식에 효과적인 치료제를 제조하는 것이다.The present invention is to prepare a therapeutic agent effective for allergic rhinitis or asthma by the following process.

제1공정: 세신, 반하, 오미자, 건강, 계지, 마황, 백작약 및 자감초를 준비하는 공정.1st process: The process which prepares sessins, halved rice, schizandra, health, gazette, ephedra, earl pear and persimmon licorice.

제2공정: 세신 15∼25중량%, 반하 15∼25중량%, 오미자 5∼10중량%, 건강 5∼10중량%, 계지 5∼15중량%, 마황 5∼10중량%, 백작약 5∼15중량% 및 자감초 2∼5중량%를 물과 함께 혼합하여 70∼90℃의 온도로 3시간 이상 가열하는 공정.Second step: 15 to 25% by weight of sesins, 15 to 25% by weight, 5 to 10% by weight of Schizandra chinensis, 5 to 10% by weight, 5 to 15% by weight, 5 to 10% by weight of ephedra, earl about 5 to 15 A step of mixing at least 3% by weight and 2-5% by weight of persimmon with water to heat at a temperature of 70 ~ 90 ℃ over 3 hours.

제3공정: 상기 공정에서 가열된 혼합물을 여과시켜 추출액을 채취하는 공정.Third step: collecting the extract by filtering the mixture heated in the step.

또한, 상기 공정에서 여과된 추출액을 분말, 과립, 정제, 캡슐 또는 시럽의 형태로 제조하는 제4공정을 포함할 수 있다.In addition, it may include a fourth step of preparing the extract filtered in the above process in the form of powder, granules, tablets, capsules or syrups.

상기 각 공정에 대하여 상세히 설명하면 아래와 같다.Hereinafter, each process will be described in detail.

상기 제1공정에서, 세신은 마두령과(쥐방울덩굴과, 학명: Aristolochiaceae)에 속한 다년생 초본인 족도리풀 및 동속 근연식물의 뿌리가 붙어있는 전초를 건조한 것으로, 메우면서 톡 쏘는 약간의 독성을 가지며, 해열, 진정, 진통 및 진해작용이 있다. 이는 족도리풀 및 동속 근연식물의 뿌리가 붙어있는 전초를 여름이나 가을에 채취하여 깨끗한 냉수에 씻은 후 그늘에서 말려야 하고, 햇빛이 직접 비치는 양지에서 건조시키면, 유효성분들이 파괴되거나 증발되므로, 그 효과가 저하되거나 원하는 정도의 추출물을 얻기 어렵게 된다.In the first step, Sessin is dried dried outposts attached to the roots of perennial herbaceous foot and coriander related plants belonging to Madhuyeong family (Russaceae, scientific name: Aristolochiaceae), and has some toxicity as it fills up. Has antipyretic, soothing, analgesic and antitussive action. This is because it is necessary to take out the outposts with foot roots and related plant roots in summer or autumn, wash them in clean cold water, dry them in the shade, and dry them in the sun, where the active ingredients are destroyed or evaporated. It is degraded or difficult to obtain the desired amount of extract.

반하는 천남성과(학명: Araceae)에 속한 다년생초본으로, 여름에 채취하여 외피와 잔뿌리를 제거하고 햇볕에 말리거나 혹은 열풍에 건조하여 사용하는 약재로서, 진해, 거담, 진토, 해독 등의 작용이 있다. 이러한 반하는 독성이 있으므로 반드시 독을 제거한 후 사용하여야 한다. 이 반하의 독을 제거하는 일반적인 방법은 생강과 백반을 이용하는 것으로서, 반하를 깨끗하고 차가운 물 속에 3∼7일간 담그되 매일 1회 갈아주면서 담갔다가 꺼내어 백반 및 생강, 생강즙과 함께 졸인 뒤에 입으로 맛을 보아 약간의 마비감이 있을 정도가 되면 꺼내어 햇볕에 말리거나 혹은 열풍에 건조하는 과정을 거치는 것이다. 독성이 제거되었는지 여부는 혀로 맛을 보아 어떤 자극이나 마비감이 있는지를 살펴 판단한다.It is a perennial herb belonging to Chunnamseong Family (Araceae). It is a herb that is collected in summer to remove the skin and fine roots, dried in the sun or dried in hot air, and has the effect of Jinhae, expectoration, clay, and detoxification. . This is toxic and must be used after detoxification. The common way to remove this poison is to use ginger and alum, which is soaked in clean and cold water for 3-7 days, soaked once every day, then taken out and boiled with alum, ginger and ginger juice, then tasted by mouth. After seeing a little numbness, you can take it out and dry it in the sun or dry it in hot air. To determine whether the poison has been removed, taste it with your tongue to determine if there is any irritation or numbness.

오미자는 목련과(학명: Magnoliaceae)에 속한 다년생 낙엽목질의 덩굴성 식물인 오미자나무 및 동속 근연식물의 성숙한 과실을 건조한 것으로, 자양강장과 진해작용이 있으며 또한 수렴성으로 체액을 생성케 하는 작용이 있다. 이는 가을철에 과실이 붉게 익었을 때 따서 햇볕에 건조하는 것이 좋으며, 곡식으로 만든 식초를 뿌리고 고르게 섞어 식초가 오미자에 완전히 흡수된 후 찜통에 넣고 쪄서 햇볕에 건조하여 사용한다. 이때, 오미자와 식초의 비율은 오미자 500g당 식초 62.5g 정도로 하는 것이 좋다.Schisandra chinensis is a dried fruit of the perennial deciduous vine, Schisandra chinensis and related plant of the genus Magnoliaceae, which has nourishing tonic and antitussive action, and also produces astringent fluid. . It is better to dry it in the sun when the fruit ripens red in the autumn. Sprinkle and mix it evenly with vinegar made of grains. After vinegar is completely absorbed by Schisandra chinensis, put it in a steamer and steam and dry it in the sun. At this time, the ratio of Schizandra vinegar is preferably about 62.5g of vinegar per 500g of Schizandra chinensis.

건강은 생강과(학명: Zingiberaceae)에 속한 다년생초본인 생강의 뿌리줄기를 건조한 것으로, 맛은 몹시 맵고 인체의 체온을 높여주는 성질이 있으며 특히 만성기관지염의 보조적 치료작용이 있다.Health is a dried root stem of the perennial herbaceous ginger belonging to the ginger family (Zingiberaceae), the taste is very spicy and increases the body temperature of the body, especially the secondary treatment of chronic bronchitis.

계지는 장과(목나무과, 학명: Lauraceae)에 속한 상록교목인 육계나무의 어린 가지를 건조한 것으로, 봄과 여름철에 잘라서 그늘에서 건조한 것으로, 항균, 항 바이러스, 이뇨 등의 작용이 있다.Gyeji is a young branch of an evergreen tree, an evergreen tree belonging to the berry family (Lauraceae), dried in the spring and summer, dried in the shade, and has antibacterial, antiviral and diuretic effects.

마황은 마황과(학명: Ephedraceae)에 속한 다년생초본 모양의 소관목인 초마황, 목적마황 및 중마황의 지상부 초질성의 줄기를 건조한 것으로, 가을에 채취하여 햇볕에 건조하며, 에페드린에 의한 심혈관의 수축, 중추의 흥분, 기관지 평활근의 진경, 골격근에 대한 항피로작용 등이 있으며 또한 이뇨작용, 인푸렌자 바이러스에 대한 억제작용 등이 있다.Ephedra is a dried perennial herbaceous subfamily of Ephedraceae, the ephedra, target ephedra, and mid ephedra, which are ground-derived superficial stems of the ephedra, which are harvested in the autumn and dried in the sun. Excitement, bronchial smooth muscle, anti-fatigue effect on skeletal muscle, diuretic effect, inhibitory effect on Inpurenza virus.

백작약은 모간과(미나리아제비과, 학명: Ranunculaceae)에 속한 다년생초본인 재배종 함박꽃과 산작약의 유백색을 띤 뿌리를 건조한 것으로, 끓는 물에 5∼10분간 담갔다가 꺼내서 햇볕에 건조하며, 진경, 진정, 진통, 항경련, 항염, 항궤양, 항균 등의 작용이 있다.Earl of Peony is a dried perennial herb, a cultivar of perennial herb, and the milky roots of wild cultivars. Anti-convulsions, anti-inflammatory, anti-ulcer, antibacterial action.

자감초는 두과(콩과, 학명: Leguminosae)에 속한 다년생초본인 감초 및 동속 근연식물의 뿌리 또는 뿌리줄기를 건조한 것으로, 봄과 가을에 캐서 햇볕에 건조하며, 약물중독, 식중독, 체내 대사물의 중독뿐만 아니라 세균독소, 즉 파상풍, 디프테리아 독소, 뱀독 등의 각종 해독작용뿐만 아니라, 항이뇨, 진해거담, 항염, 항 알레르기반응, 항궤양 및 간장보호작용 등이 있다.Licorice is a dried root or root stem of perennial herbaceous licorice and related plant of the genus Leguminosae. It is dried in the spring and autumn and sun-dried and poisoned by drug addiction, food poisoning, and metabolism in the body. As well as various detoxification functions such as bacterial toxin, ie tetanus, diphtheria toxin, snake venom, antidiuresis, antitussive expectoration, anti-inflammatory, anti-allergic reaction, anti-ulcer and hepatoprotective action.

그리고, 이들 생약성분에 대한 건조의 정도는 상대적으로 동일하여야 하며, 이는 서로 동일한 정도로 건조되어야만 서로를 혼합하였을 때 그 중량%에 의미가 있기 때문이다.In addition, the degree of drying for these herbal components should be relatively the same, because the weight percent when mixed with each other only have to be dried to the same degree.

상기 제2공정에서, 세신 15∼25중량%, 반하 15∼25중량%, 오미자 5∼10중량%, 건강 5∼10중량%, 계지 5∼15중량%, 마황 5∼10중량%, 백작약 5∼15중량% 및 자감초 2∼5중량%를 물과 함께 혼합하여 70∼90℃의 온도로 3시간 이상 가열하는데, 이때 물은 혼합된 약제무게의 약 4배 정도를 첨가하는 것이 바람직하다.여기서 가열온도를 90℃ 이상으로 하면 가열시간을 단축시킬 수 있으나 혼합물의 유효성분이 손실되기 때문에 바람직하지 않다.In the second step, 15 to 25% by weight, half to 15 to 25% by weight, 5 to 10% by weight of Schizandra chinensis, 5 to 10% by weight, 5 to 15% by weight, 5 to 10% by weight of ephedra, earl 5 15 wt% and 2-5 wt% of persimmon herb are mixed with water and heated to a temperature of 70-90 ° C. for at least 3 hours, wherein water is preferably added at about 4 times the weight of the mixed drug weight. If the heating temperature is 90 ℃ or more can be shortened the heating time is not preferable because the active ingredient of the mixture is lost.

상기 제3공정에서, 앞선 공정에서 가열된 혼합물의 상층부에는 찌꺼기 상태의 세신, 반하, 오미자, 건강, 계지, 마황, 백작약 및 자감초가 부유상태로 있고, 그 하층부에는 이들의 엑기스에 해당하는 추출액이 있게 되는데, 상층부에 있는 찌꺼기 상태의 세신, 반하, 오미자, 건강, 계지, 마황, 백작약 및 자감초를 제거하고, 하층부에 남아 있는 혼합액을 적절한 여과기에 여과시켜서 추출액을 얻어 이에 의해 알레르기성 비염 및 천식 치료제를 완성하는 공정이다.In the third step, the upper layer of the mixture heated in the previous process, the sessine, half, Schisandra chinensis, health, gage, ephedra, earl and jasmine liquor in the suspended state in the floating state, the lower layer of the extract corresponding to their extract This can be done by removing the sesame, halves, schizandrae, health, bastard, ephedra, earl pear and persimmon in the upper layer, and filtering the mixed solution remaining in the lower layer in an appropriate filter to obtain an extract, thereby allergic rhinitis and It is the process of completing the treatment for asthma.

물론, 이렇게 알레르기성 비염 및 천식 치료제를 액상 상태로 완성하여도 좋으나, 상기 제4공정에서와 같이 분말, 과립, 정제, 캡슐 또는 시럽의 형태로 완성하여도 좋다.Of course, the allergic rhinitis and asthma treatment may be completed in a liquid state, but may be completed in the form of powder, granules, tablets, capsules or syrups as in the fourth step.

이하, 본 발명을 실시예에 의거하여 설명한다.EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated based on an Example.

실시예 1Example 1

반하, 세신, 오미자, 건강, 계지, 마황, 백작약 및 자감초를 상기 제1공정에 기재된 방법에 따라 각각 준비한 후, 반하 25중량%, 세신 20중량%, 오미자, 건강, 계지, 마황, 백작약 각각 10중량% 및 자감초 5중량%의 비율로 이루어진 혼합물 1,000g에 물 40ℓ를 첨가하여 70∼90℃로 3시간 동안 가열하였다. 그리고, 이렇게 가열된 혼합물의 상부에 있는 찌꺼기를 제거하고 그 하부에 있는 잔존물을 여과하여 알레르기성 비염 및 천식 치료제인 추출물을 얻었다.Half, Sessin, Schisandra chinensis, Health, Caesar, ephedra, Baekjak and Jasimchok respectively prepared in accordance with the method described in the first step, then 25% by weight, Sesin 20% by weight, Schisandra, health, kaji, ephedra, Baekjak respectively 40 liters of water was added to 1,000 g of the mixture consisting of 10% by weight and 5% by weight of persimmon liquor and heated to 70-90 ° C. for 3 hours. Then, the residue at the top of the heated mixture was removed and the residue at the bottom of the mixture was filtered to obtain an extract for treating allergic rhinitis and asthma.

얻어진 추출물을 이용하여 알레르기성 비염 환자 50명을 대상으로 임상실험을 하였다. 실험대상의 연령은 10∼70세로 다양하였으며 남자와 여자가 각각 32명과 18명이었다. 실험방법은 1일 3회 아침, 점심, 저녁 식후 2시간에 연령과 몸무게에 따라 40∼80㎖씩 복용하게 한 다음 알레르기성 비염의 상태를 점검하였다.Clinical trials were conducted in 50 patients with allergic rhinitis using the obtained extract. The age ranged from 10 to 70 years, with 32 males and 18 females, respectively. The test method was to take 40 ~ 80ml by age and weight three times a day, two hours after breakfast, lunch and dinner, and then check the condition of allergic rhinitis.

그 결과, 환자마다 약간의 차이는 있었으나 8주가 지나면서 한사람씩 치유되기 시작하여 12주 경과하였을 때 41명이 치유되어 82%의 치유율을 나타냈다. 특히, 만성환자였던 70세 할머니가 16주 경과하였을 때 완치되었음을 확인하였다. 여기서, 치유되지 않은 9명의 경우 정해진 시간에 추출물을 복용하지 않았거나 위궤양, 십이지장, 궤양 등 다른 질병을 가지고 있는 것으로 나타났으며, 이 경우에도 알레르기성 비염이 악화되는 등 다른 부작용은 나타나지 않았다.As a result, there was a slight difference in each patient, but after 8 weeks, one person started to heal, and after 12 weeks, 41 patients were healed and showed a healing rate of 82%. In particular, the 70-year-old grandmother who was a chronic patient was confirmed to be cured when 16 weeks passed. Here, nine patients who did not healed did not take the extract at a fixed time or had other diseases such as gastric ulcer, duodenum and ulcer, and even in this case, allergic rhinitis worsened and no other side effects appeared.

실시예 2Example 2

실시예 1에서 얻어진 추출물을 이용하여 천식 환자 40명을 대상으로 임상실험을 하였다. 실험대상의 연령은 40∼80세로 다양하였으며 남자와 여자가 각각 32명과 8명이었다. 실험방법은 1일 3회 아침, 점심, 저녁 식후 2시간에 연령과 몸무게에 따라 60∼80㎖씩 복용하게 한 다음 천식의 상태를 점검하였다.Using the extract obtained in Example 1, 40 asthma patients were clinically tested. The age ranged from 40 to 80 years, with 32 males and 8 females, respectively. The test method was to take 60 ~ 80ml three times a day, depending on age and weight in the morning, lunch, dinner 2 hours after meals and then check the status of asthma.

그 결과, 환자마다 약간의 차이는 있었으나 8주가 지나면서 한사람씩 치유되기 시작하여 12주 경과하였을 때 32명이 치유되어 80%의 치유율을 나타냈다.As a result, there was a slight difference between patients, but after 8 weeks, one person started to heal, and 12 weeks later, 32 patients were healed and showed 80% healing rate.

실시예 3Example 3

실시예 1에서 얻어진 추출물의 일부를 농축하고 그에 가당하여 시럽제를 만들고, 냉동건조하여 분말제와 과립제를 만들고, 증량제를 넣어 정으로 만들고, 또한 상기 분말제나 과립제를 캡슐에 넣어 습기나 햇빛으로부터 보호하는 캡슐제로만들어서, 상기 실시예 1과 실시예 2의 대상자들에게 액상의 추출물과 함께 혼용하여 복용시킨 결과 그 효능에 차이가 없음을 확인하였다.A part of the extract obtained in Example 1 was concentrated and added thereto to make a syrup, and freeze-dried to make powders and granules, to make tablets with an extender, and to encapsulate the powder or granules in a capsule to protect from moisture or sunlight. Made with capsules, the subjects of Example 1 and Example 2 were mixed with a liquid extract and were found to have no difference in efficacy.

이상의 실시예들에서 알 수 있듯이, 본 발명에 의한 알레르기성 비염 및 천식 치료제는 점막을 부드럽게 해주고 진한 가래를 묽게 해주며 호흡기와 폐의 호흡순환을 촉진시킴으로써 알레르기성 비염 및 천식을 치료하는데 효과를 나타냈으며, 어떠한 부작용도 발생되지 않았음을 확인하였다.As can be seen from the above embodiments, the allergic rhinitis and asthma treatment agent according to the present invention is effective in treating allergic rhinitis and asthma by softening the mucous membranes, diluting dark phlegm and promoting respiratory circulation of the respiratory tract and lungs. And no side effects occurred.

또한, 본 발명에 의한 알레르기성 비염 및 천식 치료제는 그를 구성하는 반하, 세신, 오미자, 건강, 계지, 마황, 백작약 및 자감초의 어느 하나만을 단독으로 사용했을 때를 비교하였을 때 그 효과가 훨씬 크다는 것을 확인할 수 있었으며, 이는 반하, 세신, 오미자, 건강, 계지, 마황, 백작약 및 자감초 각각의 성분들이 서로 조화되어 알레르기성 비염 및 천식 치료시 상승 효과를 이룸에 기인한 것으로 예측된다.In addition, the allergic rhinitis and asthma treatment agent according to the present invention has a much greater effect when compared to using only one of the contrary, sessin, Schisandra chinensis, health, gyeji, ephedra, earl and jasmine herb which constitutes it. It can be confirmed that this is due to the combination of half, sessin, Schisandra chinensis, health, cinnamon, ephedra, earl and jasmine herb to each other, synergistic effect in the treatment of allergic rhinitis and asthma.

이상에서 설명한 바와 같이 본 발명의 알레르기성 비염 및 천식 치료제는 점막을 부드럽게 해주고 진한 가래를 묽게 해주며 호흡기와 폐의 호흡순환을 촉진시킴으로써 알레르기성 비염 및 천식을 치료하는 효과가 있다.As described above, the allergic rhinitis and asthma treatment agent of the present invention has an effect of treating allergic rhinitis and asthma by softening mucous membranes, diluting dark phlegm and promoting respiratory circulation of the respiratory tract and lungs.

또한 본 발명에 의한 알레르기성 비염 및 천식 치료제는 알레르기성 비염이나 천식에 효과가 있는 생약성분의 어느 하나만을 단독으로 사용했을 때 보다 그 효능이 향상되고 또한 부작용이 없는 장점이 있다.In addition, the allergic rhinitis and asthma treatment agent according to the present invention has the advantage that the efficacy is improved and no side effects than when using only one of the herbal ingredients effective in allergic rhinitis or asthma.

또한 본 발명의 알레르기성 및 천식에 효능이 있는 치료제는 생약성분으로이루어져 만성적이면서 잘 낫지 않는 경우에도 부작용이 없이 장시간 사용할 수 있는 효과가 있다.In addition, the therapeutic agent that is effective in allergic and asthma of the present invention is made of herbal ingredients have a long time without side effects even when chronic and not well.

Claims (3)

세신, 반하, 오미자, 건강, 계지, 마황, 백작약 및 자감초를 준비하는 공정; 세신 15∼25중량%, 반하 15∼25중량%, 오미자 5∼10중량%, 건강 5∼10중량%, 계지 5∼15중량%, 마황 5∼10중량%, 백작약 5∼15중량% 및 자감초 2∼5중량%를 이 한약재 총 중량의 30∼50배의 물과 함께 혼합하여 70∼90℃의 온도로 3시간 이상 가열하는 공정; 및 상기 공정에서 가열된 혼합물을 여과하여 추출액을 얻는 공정을 포함하는 알레르기성 비염 및 천식 치료제 제조방법.Preparing sessin, half, schisandra chinensis, health, kiji, ephedra, earl and persimmon licorice; 15 to 25% by weight, half to 15 to 25% by weight, 5 to 10% by weight of Schisandra chinensis, 5 to 10% by weight, 5 to 15% by weight, ephedra 5 to 10% by weight, 5 to 15% by weight Mixing 2 to 5% by weight licorice with water at 30 to 50 times the total weight of the medicinal herb and heating at a temperature of 70 to 90 ° C. for at least 3 hours; And filtering the heated mixture in the process to obtain an extract. 제1항의 방법에 의하여 제조된 알레르기성 비염 및 천식 치료제.A therapeutic agent for allergic rhinitis and asthma produced by the method of claim 1. 제2항에 있어서, 분말, 과립, 정제, 캡슐 또는 시럽의 형태로 제조됨을 특징으로 하는 알레르기성 비염 및 천식 치료제.The agent for treating allergic rhinitis and asthma according to claim 2, which is prepared in the form of powder, granules, tablets, capsules or syrups.
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