KR20010041147A - 분자 생물학적 분석 및 진단을 위한 진보된 능동 장치 및 방법 - Google Patents
분자 생물학적 분석 및 진단을 위한 진보된 능동 장치 및 방법 Download PDFInfo
- Publication number
- KR20010041147A KR20010041147A KR1020007009196A KR20007009196A KR20010041147A KR 20010041147 A KR20010041147 A KR 20010041147A KR 1020007009196 A KR1020007009196 A KR 1020007009196A KR 20007009196 A KR20007009196 A KR 20007009196A KR 20010041147 A KR20010041147 A KR 20010041147A
- Authority
- KR
- South Korea
- Prior art keywords
- electronic device
- electrode
- substrate
- circuit
- array
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 62
- 238000004458 analytical method Methods 0.000 title claims description 25
- 238000012546 transfer Methods 0.000 claims abstract description 102
- 239000000463 material Substances 0.000 claims abstract description 48
- 239000012620 biological material Substances 0.000 claims abstract description 28
- 239000000758 substrate Substances 0.000 claims description 184
- 239000000523 sample Substances 0.000 claims description 58
- 239000000565 sealant Substances 0.000 claims description 35
- 239000012530 fluid Substances 0.000 claims description 25
- 238000012360 testing method Methods 0.000 claims description 25
- 230000006870 function Effects 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 16
- 230000004044 response Effects 0.000 claims description 10
- 230000003068 static effect Effects 0.000 claims description 8
- 230000009467 reduction Effects 0.000 claims description 7
- 229910000679 solder Inorganic materials 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 230000003993 interaction Effects 0.000 claims description 5
- 239000004065 semiconductor Substances 0.000 claims description 5
- 230000007423 decrease Effects 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 238000013459 approach Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 229920001940 conductive polymer Polymers 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 229910052738 indium Inorganic materials 0.000 claims description 3
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 3
- 239000004593 Epoxy Substances 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 238000009429 electrical wiring Methods 0.000 claims 2
- 230000008512 biological response Effects 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 12
- 238000013461 design Methods 0.000 abstract description 8
- 230000003247 decreasing effect Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 116
- 108020004414 DNA Proteins 0.000 description 35
- 238000009396 hybridization Methods 0.000 description 35
- 238000010586 diagram Methods 0.000 description 19
- 239000010410 layer Substances 0.000 description 15
- 230000008569 process Effects 0.000 description 11
- 238000003556 assay Methods 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 238000003752 polymerase chain reaction Methods 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 230000003321 amplification Effects 0.000 description 7
- 239000002801 charged material Substances 0.000 description 7
- 238000005286 illumination Methods 0.000 description 7
- 238000003199 nucleic acid amplification method Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 238000007493 shaping process Methods 0.000 description 7
- 238000003491 array Methods 0.000 description 6
- 238000007689 inspection Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000009871 nonspecific binding Effects 0.000 description 5
- 238000007899 nucleic acid hybridization Methods 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000005669 field effect Effects 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 239000003298 DNA probe Substances 0.000 description 3
- 101100523503 Oryza sativa subsp. japonica RAC5 gene Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 101100492664 Arabidopsis thaliana ATA7 gene Proteins 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000004070 electrodeposition Methods 0.000 description 2
- 208000016361 genetic disease Diseases 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229910052727 yttrium Inorganic materials 0.000 description 2
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000009141 biological interaction Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008826 genomic mutation Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011325 microbead Substances 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 238000002966 oligonucleotide array Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920005591 polysilicon Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000006853 reporter group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
- G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C19/00—Digital stores in which the information is moved stepwise, e.g. shift registers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L29/00—Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having potential barriers; Capacitors or resistors having potential barriers, e.g. a PN-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
- H01L29/66—Types of semiconductor device ; Multistep manufacturing processes therefor
- H01L29/66007—Multistep manufacturing processes
- H01L29/66075—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials
- H01L29/66227—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials the devices being controllable only by the electric current supplied or the electric potential applied, to an electrode which does not carry the current to be rectified, amplified or switched, e.g. three-terminal devices
- H01L29/66409—Unipolar field-effect transistors
- H01L29/66477—Unipolar field-effect transistors with an insulated gate, i.e. MISFET
- H01L29/6656—Unipolar field-effect transistors with an insulated gate, i.e. MISFET using multiple spacer layers, e.g. multiple sidewall spacers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/0001—Technical content checked by a classifier
- H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Power Engineering (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Mathematical Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Fluid Mechanics (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Computer Hardware Design (AREA)
- General Physics & Mathematics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/026,618 | 1998-02-20 | ||
| US09/026,618 US6099803A (en) | 1994-07-07 | 1998-02-20 | Advanced active electronic devices for molecular biological analysis and diagnostics |
| US09/239,598 US6331274B1 (en) | 1993-11-01 | 1999-01-29 | Advanced active circuits and devices for molecular biological analysis and diagnostics |
| US09/240,931 US6315953B1 (en) | 1993-11-01 | 1999-01-29 | Devices for molecular biological analysis and diagnostics including waveguides |
| US09/240,489 | 1999-01-29 | ||
| US09/239,569 US6068818A (en) | 1993-11-01 | 1999-01-29 | Multicomponent devices for molecular biological analysis and diagnostics |
| US09/240,489 US6225059B1 (en) | 1993-11-01 | 1999-01-29 | Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics |
| US09/239,569 | 1999-01-29 | ||
| US09/240,920 | 1999-01-29 | ||
| US09/240,920 US6254827B1 (en) | 1993-11-01 | 1999-01-29 | Methods for fabricating multi-component devices for molecular biological analysis and diagnostics |
| US09/240,931 | 1999-01-29 | ||
| US09/239,598 | 1999-01-29 | ||
| PCT/US1999/003080 WO1999042558A1 (fr) | 1998-02-20 | 1999-02-11 | Dispositifs actifs evolues et procedes d'analyse et de diagnostic en biologie moleculaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010041147A true KR20010041147A (ko) | 2001-05-15 |
Family
ID=27556084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007009196A KR20010041147A (ko) | 1998-02-20 | 1999-02-11 | 분자 생물학적 분석 및 진단을 위한 진보된 능동 장치 및 방법 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1054949A4 (fr) |
| JP (1) | JP2003524750A (fr) |
| KR (1) | KR20010041147A (fr) |
| CN (1) | CN1237165C (fr) |
| AU (1) | AU742960B2 (fr) |
| BR (1) | BR9909207A (fr) |
| CA (1) | CA2320798C (fr) |
| NZ (1) | NZ506204A (fr) |
| WO (1) | WO1999042558A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200106925A (ko) * | 2018-01-08 | 2020-09-15 | 퀀텀-에스아이 인코포레이티드 | 서브-미크론-스케일 반응 챔버들의 전기동역학적 로딩을 위한 시스템 및 방법 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| AU6751800A (en) * | 1999-08-13 | 2001-03-13 | Aventis Research And Technologies Gmbh | Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening |
| WO2001016859A2 (fr) * | 1999-08-27 | 2001-03-08 | Pljvita Corporation | Systeme et methode d'evaluation genomique et proteomique de maladies animales par comparaison de profils d'expression |
| US6569674B1 (en) | 1999-12-15 | 2003-05-27 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
| US6589778B1 (en) | 1999-12-15 | 2003-07-08 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
| EP1242819A2 (fr) * | 1999-12-15 | 2002-09-25 | Motorola, Inc. | Compositions et procede permettant de realiser des reactions biologiques |
| DE10015818A1 (de) | 2000-03-30 | 2001-10-18 | Infineon Technologies Ag | Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor |
| DE10049901C2 (de) * | 2000-10-10 | 2003-01-02 | Aventis Res & Tech Gmbh & Co | Vorrichtung und Verfahren zur elektrisch beschleunigten Immobilisierung und zur Detektion von Molekülen |
| JP2004524909A (ja) | 2001-03-09 | 2004-08-19 | ジョージア テック リサーチ コーポレイション | 血管の軸方向への伸張のための脈管内デバイスおよび方法 |
| DE10122659A1 (de) * | 2001-05-10 | 2002-12-05 | Infineon Technologies Ag | Biochip-Anordnung |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| US7198754B2 (en) | 2001-08-31 | 2007-04-03 | Kabushiki Kaisha Toshiba | Biological material detection element, biological material detection method and apparatus, charged material moving apparatus |
| JP3848226B2 (ja) * | 2001-08-31 | 2006-11-22 | 株式会社東芝 | 生体物質検出装置及び生体物質検出素子 |
| WO2003029830A1 (fr) * | 2001-10-03 | 2003-04-10 | Genomic Solutions Acquisitions Limited | Procede de nettoyage |
| GB0200705D0 (en) * | 2002-01-14 | 2002-02-27 | Univ Cambridge Tech | Fluid movement |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| CN1429917A (zh) * | 2002-10-11 | 2003-07-16 | 薛永新 | 艾滋病毒原位核酸芯片及其制备方法 |
| DE102004010635B4 (de) * | 2004-03-02 | 2006-10-05 | Micronas Gmbh | Vorrichtung zur Durchführung von Messungen an Biokomponenten |
| NL1031465C2 (nl) * | 2006-03-30 | 2007-10-03 | C2V B V | Werkwijze voor het opbouwen van een inrichting met fluïdische en elektrische functies. |
| WO2008020364A2 (fr) * | 2006-08-14 | 2008-02-21 | Koninklijke Philips Electronics N. V. | Capteur biochimique |
| EP2092322B1 (fr) * | 2006-12-14 | 2016-02-17 | Life Technologies Corporation | Procédés et appareil permettant de mesurer des analytes en utilisant des matrices de tec à grande échelle |
| CH701701A2 (de) * | 2009-08-28 | 2011-02-28 | Kgmed Gmbh | Verfahren zur eichung einer diagnostischen messvorrichtung. |
| CN111229342B (zh) * | 2020-01-17 | 2022-02-11 | 上海新微技术研发中心有限公司 | 基于cmos图像传感的光栅波导多微流道芯片的制造方法 |
| CN112517093A (zh) * | 2020-11-17 | 2021-03-19 | 四川大学 | 一种Fish唾液自动分样检测盘及其检测方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0213825A3 (fr) * | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Capacitance multiple chimiquement modulée |
| US4787963A (en) * | 1987-05-04 | 1988-11-29 | Syntro Corporation | Method and means for annealing complementary nucleic acid molecules at an accelerated rate |
| EP0376611A3 (fr) * | 1988-12-30 | 1992-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Système électrophorétique |
| US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| DE69233087T2 (de) * | 1991-11-22 | 2003-12-24 | Affymetrix Inc N D Ges D Staat | Verfahren zur Herstellung von Polymerarrays |
| JPH05236997A (ja) * | 1992-02-28 | 1993-09-17 | Hitachi Ltd | ポリヌクレオチド捕捉用チップ |
| US5728532A (en) * | 1996-05-31 | 1998-03-17 | Ackley; Donald E. | Electrode configuration for matrix addressing of a molecular detection device |
-
1999
- 1999-02-11 CA CA002320798A patent/CA2320798C/fr not_active Expired - Fee Related
- 1999-02-11 EP EP99908135A patent/EP1054949A4/fr not_active Withdrawn
- 1999-02-11 CN CNB998050032A patent/CN1237165C/zh not_active Expired - Fee Related
- 1999-02-11 NZ NZ506204A patent/NZ506204A/xx unknown
- 1999-02-11 BR BR9909207-7A patent/BR9909207A/pt not_active IP Right Cessation
- 1999-02-11 JP JP2000532499A patent/JP2003524750A/ja active Pending
- 1999-02-11 AU AU27638/99A patent/AU742960B2/en not_active Ceased
- 1999-02-11 KR KR1020007009196A patent/KR20010041147A/ko not_active Application Discontinuation
- 1999-02-11 WO PCT/US1999/003080 patent/WO1999042558A1/fr not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200106925A (ko) * | 2018-01-08 | 2020-09-15 | 퀀텀-에스아이 인코포레이티드 | 서브-미크론-스케일 반응 챔버들의 전기동역학적 로딩을 위한 시스템 및 방법 |
| US11932906B2 (en) | 2018-01-08 | 2024-03-19 | Quantum-Si Incorporated | System and methods for electrokinetic loading of sub-micron-scale reaction chambers |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003524750A (ja) | 2003-08-19 |
| EP1054949A1 (fr) | 2000-11-29 |
| BR9909207A (pt) | 2001-11-06 |
| AU2763899A (en) | 1999-09-06 |
| CN1296525A (zh) | 2001-05-23 |
| CA2320798A1 (fr) | 1999-08-26 |
| WO1999042558A1 (fr) | 1999-08-26 |
| CA2320798C (fr) | 2008-01-15 |
| AU742960B2 (en) | 2002-01-17 |
| CN1237165C (zh) | 2006-01-18 |
| EP1054949A4 (fr) | 2006-09-27 |
| NZ506204A (en) | 2003-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6068818A (en) | Multicomponent devices for molecular biological analysis and diagnostics | |
| US7425308B2 (en) | Systems for the active electronic control of biological reactions | |
| US6254827B1 (en) | Methods for fabricating multi-component devices for molecular biological analysis and diagnostics | |
| US6225059B1 (en) | Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics | |
| US6821729B2 (en) | Devices for molecular biological analysis and diagnostics including waveguides | |
| KR20010041147A (ko) | 분자 생물학적 분석 및 진단을 위한 진보된 능동 장치 및 방법 | |
| US6099803A (en) | Advanced active electronic devices for molecular biological analysis and diagnostics | |
| US6245508B1 (en) | Method for fingerprinting utilizing an electronically addressable array | |
| CA2169852C (fr) | Systemes et dispositifs microelectroniques a auto-adressage et auto-assemblage destines a des analyses et diagnostics de biologie moleculaire | |
| US6287517B1 (en) | Laminated assembly for active bioelectronic devices | |
| US7172864B1 (en) | Methods for electronically-controlled enzymatic reactions | |
| US7704726B2 (en) | Active programmable matrix devices | |
| US6726880B1 (en) | Electronic device for performing active biological operations and method of using same | |
| AU746974B2 (en) | Method for electronically controlled enzymatic reaction at an addressable location | |
| AU4889000A (en) | Methods for fingerprinting utilizing an electronically addressable array |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |