BR9909207A - Dispositivos e métodos ativos avançados para análises e diagnósticos biológicos moleculares - Google Patents

Dispositivos e métodos ativos avançados para análises e diagnósticos biológicos moleculares

Info

Publication number
BR9909207A
BR9909207A BR9909207-7A BR9909207A BR9909207A BR 9909207 A BR9909207 A BR 9909207A BR 9909207 A BR9909207 A BR 9909207A BR 9909207 A BR9909207 A BR 9909207A
Authority
BR
Brazil
Prior art keywords
methods
devices
materials
molecular biological
biological analysis
Prior art date
Application number
BR9909207-7A
Other languages
English (en)
Inventor
Donald E Ackley
Paul D Swanson
Scott O Graham
Elizabeth L Mather
Timothy L Leclair
William F Butler
Original Assignee
Nanogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/026,618 external-priority patent/US6099803A/en
Priority claimed from US09/239,598 external-priority patent/US6331274B1/en
Priority claimed from US09/240,931 external-priority patent/US6315953B1/en
Priority claimed from US09/240,920 external-priority patent/US6254827B1/en
Priority claimed from US09/240,489 external-priority patent/US6225059B1/en
Priority claimed from US09/239,569 external-priority patent/US6068818A/en
Application filed by Nanogen Inc filed Critical Nanogen Inc
Publication of BR9909207A publication Critical patent/BR9909207A/pt

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C19/00—Digital stores in which the information is moved stepwise, e.g. shift registers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L29/00—Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having potential barriers; Capacitors or resistors having potential barriers, e.g. a PN-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
    • H01L29/66—Types of semiconductor device ; Multistep manufacturing processes therefor
    • H01L29/66007—Multistep manufacturing processes
    • H01L29/66075—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials
    • H01L29/66227—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials the devices being controllable only by the electric current supplied or the electric potential applied, to an electrode which does not carry the current to be rectified, amplified or switched, e.g. three-terminal devices
    • H01L29/66409—Unipolar field-effect transistors
    • H01L29/66477—Unipolar field-effect transistors with an insulated gate, i.e. MISFET
    • H01L29/6656—Unipolar field-effect transistors with an insulated gate, i.e. MISFET using multiple spacer layers, e.g. multiple sidewall spacers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Power Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mathematical Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Fluid Mechanics (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Patente de Invenção: "DISPOSITIVOS E MéTODOS ATIVOS AVANçADOS PARA ANáLISES E DIAGNóSTICOS BIOLóGICOS MOLECULARES". Métodos de fabricação e dispositivos para a realização de operações biológicas ativas utilizam várias estruturas, para, vantajosamente, coletarem e proverem materiais biológicos carregados para um arranjo de microlocais. Em uma modalidade, um dispositivo inclui eletrodos de focalização, para ajudar na direção e no transporte de materiais de um eletrodo de coleta para um arranjo. Preferencialmente, um ou mais eletrodos de transporte intermediário são utilizados, mais preferencialmente de tamanho monotonicamente decrescente entre o eletrodo de coleta e o arranjo, de modo a reduzir as não combinações de densidade de corrente. Em um outro aspecto, uma célula de fluxo é utilizada em relação a dispositivos, para prover uma contenção de uma solução que tenha materiais a serem analisados. Ainda em uma outra realização, um projeto de anel concêntrico é provido. Várias realizações de conglomerado de terminais são mostradas.
BR9909207-7A 1998-02-20 1999-02-11 Dispositivos e métodos ativos avançados para análises e diagnósticos biológicos moleculares BR9909207A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09/026,618 US6099803A (en) 1994-07-07 1998-02-20 Advanced active electronic devices for molecular biological analysis and diagnostics
US09/239,598 US6331274B1 (en) 1993-11-01 1999-01-29 Advanced active circuits and devices for molecular biological analysis and diagnostics
US09/240,931 US6315953B1 (en) 1993-11-01 1999-01-29 Devices for molecular biological analysis and diagnostics including waveguides
US09/240,920 US6254827B1 (en) 1993-11-01 1999-01-29 Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US09/240,489 US6225059B1 (en) 1993-11-01 1999-01-29 Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US09/239,569 US6068818A (en) 1993-11-01 1999-01-29 Multicomponent devices for molecular biological analysis and diagnostics
PCT/US1999/003080 WO1999042558A1 (en) 1998-02-20 1999-02-11 Advanced active devices and methods for molecular biological analysis and diagnostics

Publications (1)

Publication Number Publication Date
BR9909207A true BR9909207A (pt) 2001-11-06

Family

ID=27556084

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909207-7A BR9909207A (pt) 1998-02-20 1999-02-11 Dispositivos e métodos ativos avançados para análises e diagnósticos biológicos moleculares

Country Status (9)

Country Link
EP (1) EP1054949A4 (pt)
JP (1) JP2003524750A (pt)
KR (1) KR20010041147A (pt)
CN (1) CN1237165C (pt)
AU (1) AU742960B2 (pt)
BR (1) BR9909207A (pt)
CA (1) CA2320798C (pt)
NZ (1) NZ506204A (pt)
WO (1) WO1999042558A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
CA2381750A1 (en) * 1999-08-13 2001-02-22 Nanogen, Inc. Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening
AU7826100A (en) * 1999-08-27 2001-03-26 Pluvita Corporation System and method for genomic and proteomic agricultural disease assessment via expression profile comparison
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6589778B1 (en) 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
EP1242819A2 (en) * 1999-12-15 2002-09-25 Motorola, Inc. Apparatus for performing biological reactions
DE10015818A1 (de) 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor
DE10049901C2 (de) * 2000-10-10 2003-01-02 Aventis Res & Tech Gmbh & Co Vorrichtung und Verfahren zur elektrisch beschleunigten Immobilisierung und zur Detektion von Molekülen
WO2002071980A2 (en) 2001-03-09 2002-09-19 Georgia Tech Research Corporation Intravascular device and method for axially stretching blood vessels
DE10122659A1 (de) * 2001-05-10 2002-12-05 Infineon Technologies Ag Biochip-Anordnung
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
JP3848226B2 (ja) * 2001-08-31 2006-11-22 株式会社東芝 生体物質検出装置及び生体物質検出素子
US7198754B2 (en) 2001-08-31 2007-04-03 Kabushiki Kaisha Toshiba Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
WO2003029830A1 (en) * 2001-10-03 2003-04-10 Genomic Solutions Acquisitions Limited Cleaning method
GB0200705D0 (en) * 2002-01-14 2002-02-27 Univ Cambridge Tech Fluid movement
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
CN1429917A (zh) * 2002-10-11 2003-07-16 薛永新 艾滋病毒原位核酸芯片及其制备方法
DE102004010635B4 (de) * 2004-03-02 2006-10-05 Micronas Gmbh Vorrichtung zur Durchführung von Messungen an Biokomponenten
NL1031465C2 (nl) * 2006-03-30 2007-10-03 C2V B V Werkwijze voor het opbouwen van een inrichting met fluïdische en elektrische functies.
WO2008020364A2 (en) * 2006-08-14 2008-02-21 Koninklijke Philips Electronics N. V. Biochemical sensor device
EP4134667A1 (en) * 2006-12-14 2023-02-15 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
CH701701A2 (de) * 2009-08-28 2011-02-28 Kgmed Gmbh Verfahren zur eichung einer diagnostischen messvorrichtung.
CN114950588A (zh) 2018-01-08 2022-08-30 宽腾矽公司 用于亚微米级反应室的电气动力装载的系统及方法
CN111229342B (zh) * 2020-01-17 2022-02-11 上海新微技术研发中心有限公司 基于cmos图像传感的光栅波导多微流道芯片的制造方法
CN112517093A (zh) * 2020-11-17 2021-03-19 四川大学 一种Fish唾液自动分样检测盘及其检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
EP0376611A3 (en) * 1988-12-30 1992-07-22 The Board Of Trustees Of The Leland Stanford Junior University Electrophoretic system
US5527681A (en) * 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
US5728532A (en) * 1996-05-31 1998-03-17 Ackley; Donald E. Electrode configuration for matrix addressing of a molecular detection device

Also Published As

Publication number Publication date
NZ506204A (en) 2003-06-30
EP1054949A1 (en) 2000-11-29
CN1296525A (zh) 2001-05-23
EP1054949A4 (en) 2006-09-27
CA2320798C (en) 2008-01-15
WO1999042558A1 (en) 1999-08-26
CN1237165C (zh) 2006-01-18
AU2763899A (en) 1999-09-06
JP2003524750A (ja) 2003-08-19
CA2320798A1 (en) 1999-08-26
AU742960B2 (en) 2002-01-17
KR20010041147A (ko) 2001-05-15

Similar Documents

Publication Publication Date Title
BR9909207A (pt) Dispositivos e métodos ativos avançados para análises e diagnósticos biológicos moleculares
DE69033969D1 (de) Komponenten für elektrochemische Zellen und ihre Verwendung in Sauerstofftrennung
DE69104440D1 (de) Dünne rohrförmige selbsttragende Elektrode für elektrochemische Zellen mit Festoxidelektrolyten.
DE69207637D1 (de) Luftelektrode und damit ausgerüstete Festelektrolyt-Brennstoffzelle
EP1722431A3 (en) Secondary battery using a radical compound as active electrode material
DE60235944D1 (de) Positives aktives Elektrodenmaterial, positive Elektrode und nicht-wässrige sekundäre Elektrolytbatterie diese benutzend
DE3481645D1 (de) Vorrichtung fuer chemische analyse und deren verwendung.
DE10347566A1 (de) Keramischer Separator für elektrochemische Zellen mit verbesserter Leitfähigkeit
DE60143375D1 (de) Nichtwässriger Elektrolyt und diesen Elektrolyten enthaltende elektrochemische Vorrichtung
NO20032961D0 (no) Flytende brenselblandinger for elektrokjemiske brenselceller
DE69204834D1 (de) Gegliederte membranelektrodenanordnung für elektrochemische brennstoffzelle.
DE69704077D1 (de) Elektrisch nichtleitende plattenstrukturen und hochdruck elektrochemische zellenvorrichtung, die diese verwendet
ATE252730T1 (de) Zelle für elektrochemilumineszenz mit potentialfreien reaktionselektroden
DE60039811D1 (de) Stromkollektor, Elektrode und diesen Stromkollektor enthaltende Sekundärbatterie
DE60332595D1 (de) Membran-Elektroden-Einheit und Polymerelektrolytbrennstoffzelle die diese Einheit enthält
DE69940559D1 (de) Elektrochemische zelle mit hohem durchsatz und ansammlungsverfahren
ATE443252T1 (de) Teilchenanalysator
DE3671233D1 (de) Substituierte benzophenone und deren fluessige mischungen, verwendbar als photoinitiatoren.
DE69729055D1 (de) Kathodenmaterial für nichtwaessrige elektrolytische zelle und zelle, die dieses verwendet
DE69306800D1 (de) Fester alkalischer polymerelektrolyt, elektrode und elektrochemischer generator, die diesen elektrolyt enthalten
FR2778023B1 (fr) Substance active positive pour batterie alcaline et electrode utilisant cette substance
DE602004016469D1 (de) Membran-Elektroden-Einheit und Polymer-Elektrolytbrennstoffzelle enthaltend diesselbe
ES2185074T3 (es) Semicelula electroquimica.
DE3583170D1 (de) Elektrode fuer brennstoffzelle, verfahren zu ihrer herstellung und diese elektrode verwendende brennstoffzelle.
DE69837190D1 (de) Elektroden-Materialien zur Verwendung in Batterien,und Elektroden und Batterien, in denen diese verwendet werden

Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009.